CN104173074B - The geometry scale method of single photon emission computed tomography (SPECT) system - Google Patents
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Abstract
The present invention proposes the geometry scale method of a kind of single photon emission computed tomography (SPECT) system, including: collimation device measures to obtain the geometric parameter of pin hole or the line of rabbet joint on collimator；Collimator and pet detector are assembled into single photon emission computed tomography (SPECT) system；Control collimator motion, to utilize many groups background when pet detector measures collimator motion to multiple target location to meet event；Meet event according to many group backgrounds and obtain collimator position coordinates in single photon emission computed tomography (SPECT) system.The geometric parameter of single photon emission computed tomography (SPECT) system (i.e. SPECT system) can be carried out exact scale by method according to embodiments of the present invention, image reconstruction for fault imaging provides accurate geometric parameter, thus improving the image quality of single photon emission computed tomography (SPECT) system.
Description
Technical field
The present invention relates to emission tomography technical field, particularly to the geometry scale method of a kind of single photon emission computed tomography (SPECT) system.
Background technology
Emission tomography technology is a kind of nuclear medicine method of non-intrusion type, its principle is the physiological metabolism using the bioactive substance of radioisotope labeling to participate in organism, utilize the distribution measuring radionuclide, the metabolism of indirect observation bioactive substance and distributed in three dimensions situation.Emission tomography includes SPECT (SinglePhotonEmissionComputedTomography) and PET (PositronEmissionTomography), they are all functional imaging techniques, are widely used to pre-clinical drug research and clinical disease diagnosis at present.SPECT is compared to the PET advantage with high-resolution and the relatively labeled drug of multiple types.
The building method of current a kind of SPECT system is the method embedding pinhole collimator (such as Fig. 1) or the line of rabbet joint (Slit-Slat) collimator (such as Fig. 2) in pet detector.The feature of the method is to utilize existing PET ring as detector, and carry out SPECT imaging in conjunction with collimator, the advantage of system is reduction of the cost of SPECT system, the physical space occupied with reduction system, and system has the motility of height, Double-mode imaging can be carried out simultaneously, be conducive to the fusion of two kinds of images.The design of this system has market application foreground widely.
Embedded PET/SPECT system often to switch in PET and SPECT different operating state, need to move in and out collimator, easily make collimator position generation micro-displacement, cause system geometric position inaccuracy, affecting SPECT picture quality, the committed step therefore obtaining high-quality SPECT image is in alignment with the exact scale of straight device position in PET system.Method conventional at present is the collection utilizing position control translation stage that gamma point source carries out with certain scanning track data for projection in visual field, obtain point source in the projection center of gravity of each movement position, utilize the pin hole of the method collimation device of least square fitting to carry out location position.
Traditional method needs to prepare the point source of reduced size, has certain difficulty, simultaneously need to complex scanning track and data fitting method, operating difficulties.
Summary of the invention
It is contemplated that at least solve one of above-mentioned technical problem.
For this, it is an object of the invention to propose the geometry scale method of a kind of single photon emission computed tomography (SPECT) system.The method can provide accurate geometric parameter for the image reconstruction of fault imaging, thus improving the image quality of single photon emission computed tomography (SPECT) system.
To achieve these goals, The embodiment provides the geometry scale method of a kind of single photon emission computed tomography (SPECT) system, described single photon emission computed tomography (SPECT) system includes pet detector and collimator, said method comprising the steps of: measure described collimator to obtain the geometric parameter of pin hole or the line of rabbet joint on described collimator；Described collimator and described pet detector are assembled into described single photon emission computed tomography (SPECT) system；Control described collimator motion, to utilize many groups background when described pet detector measures described collimator motion to multiple target location to meet event；Meet event according to described many group backgrounds and obtain described collimator position coordinates in described single photon emission computed tomography (SPECT) system.
The geometric parameter of single photon emission computed tomography (SPECT) system (i.e. SPECT system) can be carried out exact scale by method according to embodiments of the present invention, image reconstruction for fault imaging provides accurate geometric parameter, thus improving the image quality of single photon emission computed tomography (SPECT) system.
It addition, the geometry scale method of single photon emission computed tomography (SPECT) system according to the above embodiment of the present invention can also have following additional technical characteristic:
In some instances, the described collimator motion of described control, to utilize many groups background when described pet detector measures described collimator motion to multiple target location to meet event, specifically include: control in the ring that described collimator removes described pet detector, and gathered by described pet detector and meet event at the bottom of the first in the first Preset Time；Control in the ring that described collimator moves into described pet detector, and the second background gathered in the second Preset Time by described pet detector meets event；Control described collimator and be moved to predeterminable range in the ring of described pet detector, and meet event by the 3rd background in described pet detector collection the 3rd Preset Time.
In some instances, utilize the negatron of lutecium 176 decay generation and the gamma particle of cascade in pet detector to measure described many group backgrounds and meet event.
In some instances, described meet event according to described many group backgrounds and obtain described collimator position coordinates in described single photon emission computed tomography (SPECT) system, specifically include: described many group backgrounds are met event and is converted into sinogram；Image reconstruction algorithm is utilized to set up the three-dimensional attenuation image of described collimator according to described sinogram；And from the three-dimensional attenuation image of described collimator, extract described collimator position coordinates in described single photon emission computed tomography (SPECT) system；Or directly will meet event response line back projection, it is thus achieved that back projection's image of collimator, and from described back projection image, extract described collimator position coordinates in described single photon emission computed tomography (SPECT) system.
In some instances, described many group backgrounds are met event and are converted into sinogram by the method utilizing back projection；Filter back-projection algorithm or iterative reconstruction algorithm is utilized to obtain the three-dimensional attenuation image of described collimator.
In some instances, also include: be further processed on described collimator, including binding mark thing or grooving joint-cutting, to utilize described label or described grooving joint-cutting to obtain background imaging, for the geometric parameter demarcating described collimator.
In some instances, on described collimator, the geometric parameter of pin hole or the line of rabbet joint includes: position on described collimator of described pin hole or the line of rabbet joint and subtended angle.
In some instances, in the following way described collimator is measured to obtain the geometric parameter of pin hole or the line of rabbet joint on described collimator: mechanical measuring means, measuring method, imaging measurement method, method for electromagnetically measuring or Pneumatic Measuring Method of Coupled Pair.
In some instances, described collimator be shaped as ring-type, tabular or polygon, the pin hole of described collimator is circular cone, elliptic cone, round platform, elliptical table, polygonal pyramid or many terrace with edges.
In some instances, described pet detector is and the annular detector of described collimator adaptation, flat panel detector or polygon detector.
The additional aspect of the present invention and advantage will part provide in the following description, and part will become apparent from the description below, or is recognized by the practice of the present invention.
Accompanying drawing explanation
Above-mentioned and/or the additional aspect of the present invention and advantage are from conjunction with will be apparent from easy to understand the accompanying drawings below description to embodiment, wherein:
Fig. 1 is a kind of PET/SPECT system based on ring-shaped P ET detector and embedded seam-groove collimator；
Fig. 2 is a kind of PET/SPECT system based on ring-shaped P ET detector and embedded pinhole collimator；
Fig. 3 is the decay scheme of a kind of lutecium 176；
Fig. 4 is the block diagram of method according to an embodiment of the invention；
Fig. 5 is that lutecium background meets transmission imaging schematic diagram；
Fig. 6 is the schematic diagram utilizing label to measure each pin hole or the position coordinates that is carefully sewn under pet detector coordinate system；
The lutecium background of Fig. 7 cylindrical shape collimator meets the attenuation quotient figure of transmission reconstruction；
The lutecium background of Fig. 8 cylindrical shape collimator meets the direct back projection figure of transmission reconstruction；
The border of the cylindrical shape collimator that the wherein minimum point of a layer in Fig. 9 Fig. 8 obtains；
Figure 10 utilizes Fig. 9 to obtain the center point coordinate of each layer of drum collimator and matching obtains the axis of drum collimator.
Figure 11 is that the drum collimator removal 65mm lutecium background obtained meets reconstruction image；Figure 12 is the flow chart of method in accordance with another embodiment of the present invention,
In above-mentioned Fig. 1-12 label 1 refer to pet detector ring, 11,12 is collimator dividing plate, 13 is that collimator carefully stitches, 2 refer to collimator, 3 pin holes referring on collimator, 4 refer to toy to be imaged, label 5 be place toy scanning bed, 6 refer to lutecium background meet line of response, 7 is label.
Detailed description of the invention
Being described below in detail embodiments of the invention, the example of described embodiment is shown in the drawings, and wherein same or similar label represents same or similar element or has the element of same or like function from start to finish.The embodiment described below with reference to accompanying drawing is illustrative of, and is only used for explaining the present invention, and is not considered as limiting the invention.
In describing the invention, it will be appreciated that, term " " center ", " longitudinal direction ", " transverse direction ", " on ", D score, " front ", " afterwards ", " left side ", " right side ", " vertically ", " level ", " top ", " end ", " interior ", orientation or the position relationship of the instruction such as " outward " are based on orientation shown in the drawings or position relationship, it is for only for ease of the description present invention and simplifies description, rather than the device of instruction or hint indication or element must have specific orientation, with specific azimuth configuration and operation, therefore it is not considered as limiting the invention.Additionally, term " first ", " second " are only for descriptive purposes, and it is not intended that indicate or hint relative importance.
In describing the invention, it is necessary to explanation, unless otherwise clearly defined and limited, term " installation ", " being connected ", " connection " should be interpreted broadly, for instance, it is possible to it is fixing connection, it is also possible to be removably connect, or connect integratedly；Can be mechanically connected, it is also possible to be electrical connection；Can be joined directly together, it is also possible to be indirectly connected to by intermediary, it is possible to be the connection of two element internals.For the ordinary skill in the art, it is possible to concrete condition understands above-mentioned term concrete meaning in the present invention.
With reference to as explained below and accompanying drawing, it will be clear that these and other aspects of embodiments of the invention.Describe at these and in accompanying drawing, specifically disclose some particular implementation in embodiments of the invention, representing some modes of the principle implementing embodiments of the invention, but it is to be understood that the scope of embodiments of the invention is not limited.On the contrary, all changes within the scope of embodiments of the invention include falling into attached claims spirit and intension, amendment and equivalent.
The geometry scale method of single photon emission computed tomography (SPECT) system according to embodiments of the present invention is described below in conjunction with accompanying drawing.
Figure 12 is the flow chart of the geometry scale method of single photon emission computed tomography (SPECT) system according to an embodiment of the invention.As shown in figure 12, and in conjunction with Fig. 4, the geometry scale method of single photon emission computed tomography (SPECT) system according to an embodiment of the invention, wherein, single photon emission computed tomography (SPECT) system includes pet detector and collimator, and described geometry scale method comprises the steps:
Step S101: collimation device measures to obtain the geometric parameter of pin hole or the line of rabbet joint on collimator.That is: as shown in Figure 4, collimation device carries out measurement of dispatching from the factory, it is thus achieved that the geometric parameters such as each pin hole or thin seam exact position on the collimator and subtended angle.Wherein, on collimator, the geometric parameter of pin hole or the line of rabbet joint includes but not limited to: pin hole or line of rabbet joint position on the collimator and subtended angle.
Such as: collimation device carries out measurement of dispatching from the factory, it is thus achieved that the geometric parameters such as each pin hole or the line of rabbet joint (i.e. thin seam) exact position on the collimator and subtended angle.Specifically, collimation device is according to the scale that dispatches from the factory designed after being processed, owing to reality processing has slightly difference with design load, therefore the size and their positions on the collimator that need the pin hole on collimation device or thin seam before dispatching from the factory carry out scale, the geometry scale method that dispatches from the factory can be realized by traditional geometry scale method, for instance: collimation device measures to obtain the geometric parameter of pin hole or the line of rabbet joint on described collimator in the following way: mechanical measuring means, measuring method, imaging measurement method, method for electromagnetically measuring or Pneumatic Measuring Method of Coupled Pair.Namely traditional mechanical measuring means, measuring method, imaging measurement method, method for electromagnetically measuring and Pneumatic Measuring Method of Coupled Pair etc. are included.
Step S102: collimator and pet detector are assembled into PET/SPECT integrated machine system.That is: as shown in Figure 4, collimator and the mobile motor that controls are assembled into PET/SPECT integrated machine system with pet detector.
Specifically; collimator and mobile parametric controller are assembled into PET/SPECT system with pet detector; such as: collimator and pet detector are assembled by design, constitute PET/SPECT all-in-one, generally also need to control the mobile control translation stage that collimator moves.Collimation device position in pet detector ring is needed to carry out scale after assembling, such as geometric position in pet detector, the collimator center, the angle of collimator axis and pet detector axis, the initial angle etc. of pin hole or thin seam.And PET/SPECT all-in-one needs to switch under the mode of operation of SPECT and PET, namely frequent being removed by collimator and move into is needed, can there is minor shifts in collimator position in pet detector ring, it is therefore desirable to the position of irregular collimation device and pet detector ring carries out scale.
Step S103: control collimator motion, to utilize many groups background when pet detector measures collimator motion to multiple target location to meet event.That is: controlling collimator by translation stage and move in pet detector ring as shown in Figure 4, adjust PET meet can window, utilize negatron that the decay of lutecium 176 in pet detector produces and cascade gamma particle to carry out coincidence measurement.Such as utilize the negatron of lutecium 176 decay generation and the gamma particle of cascade in pet detector to measure described many group backgrounds and meet event.Namely the mobile translation stage (such as motor) that controls controls collimator and moves in pet detector ring, adjust PET meet can window, utilize the gamma particle of negatron that in pet detector, lutecium 176 decay produces and cascade to carry out coincidence measurement.
Specifically, control collimator motion, to utilize many groups background when pet detector measures collimator motion to multiple target location to meet event, specifically include:
1, control in the ring that described collimator removes described pet detector, and gathered by described pet detector and meet event at the bottom of the first in the first Preset Time；
2, control in the ring that described collimator moves into described pet detector, and the second background gathered in the second Preset Time by described pet detector meets event；
3, control described collimator and be moved to predeterminable range in the ring of described pet detector, and meet event by the 3rd background in described pet detector collection the 3rd Preset Time.
In the examples described above, the first Preset Time is but is not limited to [15,25] hour, and the second Preset Time and the 3rd Preset Time are but are not limited to [5,15] hour, and predeterminable range is but is not limited to 65 millimeters.
More specifically, due to containing lutecium crystal, as LSO LYSO the crystal such as LGSO for gamma ray, there is strong stopping power, bigger luminous quantity and shorter luminescence decay time, it is widely used in pre-clinical and clinical PET system at present, lutecium contains lutecium 176 isotope of part, there is natural background radiation, its main decay process is negatron decay (ceiling capacity 596keV) and cascade generation gamma decay (main energetic is 202keV and 307keV), and the decay scheme of lutecium 176 is as shown in Figure 3.From the foregoing, it will be observed that utilize the lutecium background of pet detector to meet event pinhole collimator is measured method namely in the relative position problem solving collimator and pet detector ring at PET.Pet detector containing lutecium crystal needs amendment to meet energy window lower threshold value, lower threshold value is adjusted lower than 202keV, the negatron of the generation of the decay of lutecium 176 in certain crystal and escape and the cascade gamma particle detected by other crystal of detector can be measured simultaneously, formed and meet detection.Collimator is placed in the pet detector visual field, the gamma particle escaped can be stopped and absorb, and meeting event hence with the lutecium background of PET can measure the transmission imaging figure that can obtain similar computer tomography (CT) by collimator.The present invention utilizes PET to meet imaging and lutecium 176 produces the transmission imaging principle of gamma ray collimation device and is operated, and lutecium background meets transmission imaging principle as shown in Figure 5.
Step S104: meet event according to many group backgrounds and obtain collimator position coordinates in single photon emission computed tomography (SPECT) system.The reconstruction image zooming-out collimator position coordinates in PET system by gathering data as shown in Figure 4.That is: the data gathered are rebuild, from the image rebuild, extract collimator position coordinates in PET system.
As a concrete example, meet event according to many group backgrounds and obtain collimator position coordinates in single photon emission computed tomography (SPECT) system, specifically include:
1, meet event be converted into sinogram by organizing background more；
2, image reconstruction algorithm is utilized to set up the three-dimensional attenuation image of collimator according to sinogram；
3, from the three-dimensional attenuation image of collimator, collimator position coordinates in single photon emission computed tomography (SPECT) system is extracted.
In the examples described above, the method for available back projection meets event be converted into sinogram by organizing background more, utilizes filter back-projection algorithm or iterative reconstruction algorithm to obtain the three-dimensional attenuation image of collimator.
The method of the embodiment of the present invention it is crucial that the radioactive intensity of background ray is more weak, the simultaneously limited spatial resolution of pet detector, therefore at short notice, only meet, from lutecium background, the accurate position coordinates being difficult to directly obtain collimator transmission imaging figure.Therefore the method for the symmetrical centre that embodiments of the invention further provide the method acquisition collimator utilizing collimator system geometrical symmetry carries out collimator geometric position scale, and said method may be directly applied to the transmission image after the sinogram data after meeting line data, restructuring, parsing or iterative approximation or transmitting image.
Utilize lutecium background collimation device to carry out the method meeting imaging it addition, above-mentioned, also include further utilizing control translation stage to move collimator in different position measurements, it is thus achieved that the collimator different geometric parameter in pet detector.
In one embodiment of the invention, also include: be further processed on the collimator, including binding mark thing or grooving joint-cutting, to utilize label or described grooving joint-cutting to obtain background imaging, for the geometric parameter demarcating described collimator.Specifically, under the premise not affecting imaging, cutting or other objects bonding form mark position on the collimator.The relative position of each pin hole or thin seam and label on collimator is measured by conventional geometric measuring method, and utilize above-mentioned lutecium background to meet transmission imaging label to carry out imaging and extracts geometric position parameter, thus indirectly measuring each pin hole or being carefully sewn on the position coordinates under pet detector coordinate system, as shown in Figure 6.
Wherein, being shaped as but be not limited to of collimator: ring-type, tabular or polygon, the pin hole of described collimator is circular cone, elliptic cone, round platform, elliptical table, polygonal pyramid or many terrace with edges.
[embodiment]
Adopting the small animal position emission tomography (PET)/SPECT system of Nucmed, as in figure 2 it is shown, wherein PET uses the annular detection system of LYSO crystal, ring diameter 152.6mm, axial visual field 100mm, embedded collimator bucket internal diameter 31.85mm, the ring of external diameter 35.35mm, material is tungsten.There are five pricking with needle holes, often row 10, as shown in Figure 6.
The method is as follows:
1) on collimator, the relative position of pin hole is fixing after machining, and adopts optic test, accurately obtains each pin hole relative position on collimator bucket.
2) collimator is fixed on electric translation turntable, is assembled into PET/SPECT all-in-one with pet detector ring.
3) pet detector lutecium background is used to carry out meeting affair.Concrete measuring process is as follows, first collimator is removed pet detector, utilizes the pet detector collection background of 20 hours to meet event (data 1), as correcting data；Secondly collimator is moved on to pet detector, utilize 10 hours backgrounds of pet detector collection to meet event (data 2)；Finally collimator is removed 65mm, utilize 10 hours backgrounds of pet detector collection to meet event (data 3).
4) gather data by three groups and be converted into positive line chart, utilize image reconstruction algorithm to obtain the image of collimator.Collimator annulus to each tomography, as illustrated in figures 7-11, is fitted obtaining round center, the more a series of round center (as illustrated in figures 7-11) obtained is carried out the estimation that namely linear fit obtains the axial location of collimator bucket；Data three are rebuild, limb recognition is carried out to rebuilding image, collimator edge position in pet detector ring can be obtained, each pin hole position coordinates on collimator bucket is crossed by known displacement 65mm and optical measurement, collimator bucket each pin hole under SPECT acquisition state axial location under pet detector coordinate system can be extrapolated, if Fig. 9 is the result that collimation bucket lutecium background under displacement 65mm state meets the direct filtered back projection of transmission imaging.
By above-mentioned 4th step, it is possible to demarcate collimator bucket axis coordinate under pet detector coordinate system, such as two angles of collimator bucket axis Yu pet detector ring axis；And can indirectly obtain pin hole at axial edge at axial coordinate by collimator bucket.
Further experiment can adopt label to carry out the pin hole demarcation in the transverse section angle of collimator bucket.
Method of the invention process can under PET acquisition pattern, it is not necessary to extra radiation source, meets imaging merely with lutecium Background radiation collimation device, and therefrom extracting parameter, for the method for the geometry scale of system.The geometric parameter of SPECT system can be carried out exact scale by the method, provides accurate geometric parameter for SPECT image reconstruction, thus improving SPECT picture quality.Additionally, the method has only to collimation device and once dispatches from the factory demarcation, the lutecium background having only to recycling pet detector afterwards meets the scale that event carries out the relative position of collimator and pet detector, the collection of complicated track is carried out without extra radioactive source, the method is simply effective, easy to implement, the collimator contributing to PET/SPECT system carries out the demarcation of irregular geometric position, thus improving the picture quality of SPECT system.
Method according to embodiments of the present invention, has the characteristics that and advantage:
1, simple, easy to implement, pin hole or thin seam position on the collimator only need to be demarcated once, and collimator is easy to implement with the demarcating steps of the relative position of pet detector, it is only necessary to adjust and can arrange by window meeting of PET acquisition.
2, extra radiation source is not needed, it is possible to avoid the operating process of complexity and radioactive source that human body causes extra radiation.
3, the method is quickly and accurately, and method utilizes the symmetry of collimator, it is possible to obtain high-precision scale at short notice, does not affect normal experiment, it is easy to irregular carry out system geometric position self-checking.
In the description of this specification, specific features, structure, material or feature that the description of reference term " embodiment ", " some embodiments ", " example ", " concrete example " or " some examples " etc. means in conjunction with this embodiment or example describe are contained at least one embodiment or the example of the present invention.In this manual, the schematic representation of above-mentioned term is not necessarily referring to identical embodiment or example.And, the specific features of description, structure, material or feature can combine in an appropriate manner in any one or more embodiments or example.
Although an embodiment of the present invention has been shown and described, it will be understood by those skilled in the art that: these embodiments can being carried out multiple change, amendment, replacement and modification when without departing from principles of the invention and objective, the scope of the present invention is by claim and equivalency thereof.
Claims (8)
1. the geometry scale method of a single photon emission computed tomography (SPECT) system, it is characterised in that described single photon emission computed tomography (SPECT) system includes pet detector and collimator, said method comprising the steps of:
Described collimator is measured to obtain the geometric parameter of pin hole or the line of rabbet joint on described collimator；
Described collimator and described pet detector are assembled into positron emission tomography PET/ single photon emission tomographic imaging SPECT all-in-one；
Control in the ring that described collimator removes described pet detector, and gathered by described pet detector and meet event at the bottom of the first in the first Preset Time；
Control described collimator and move on to SPECT mode of operation, and the second background gathered in the second Preset Time by described pet detector meets event；
Control described collimator and remove predeterminable range from SPECT mode of operation, and meet event by the 3rd background in described pet detector collection the 3rd Preset Time；
According to meeting event at the bottom of described first, described second background meets event and described 3rd background meets event and obtains described collimator position coordinates in described positron emission tomography PET/ single photon emission tomographic imaging SPECT all-in-one.
2. the geometry scale method of single photon emission computed tomography (SPECT) system according to claim 1, it is characterized in that, utilize the gamma particle of negatron that the decay of lutecium 176 in pet detector produces and cascade measure meet event at the bottom of described first, described second background meets event and described 3rd background meets event.
3. the geometry scale method of single photon emission computed tomography (SPECT) system according to claim 1, it is characterized in that, described according to meeting event at the bottom of described first, described second background meets event and described 3rd background meets event and obtains described collimator position coordinates in described positron emission tomography PET/ single photon emission tomographic imaging SPECT all-in-one, specifically include:
By meeting event at the bottom of described first, described second background meets event and described 3rd background meets event and is converted into sinogram；
Filter back-projection algorithm or iterative reconstruction algorithm is utilized to obtain the three-dimensional attenuation image of described collimator according to described sinogram；And
Described collimator position coordinates in described positron emission tomography PET/ single photon emission tomographic imaging SPECT all-in-one is extracted from the three-dimensional attenuation image of described collimator；
Or directly will meet event back projection, it is thus achieved that back projection's image；And from back projection's image of described collimator, extract described collimator position coordinates in described positron emission tomography PET/ single photon emission tomographic imaging SPECT all-in-one.
4. the geometry scale method of single photon emission computed tomography (SPECT) system according to claim 3, it is characterized in that, also include: be further processed on described collimator, including binding mark thing or grooving joint-cutting, to utilize described label or described grooving joint-cutting to obtain background imaging, for the geometric parameter demarcating described collimator.
5. the geometry scale method of single photon emission computed tomography (SPECT) system according to claim 1, it is characterised in that on described collimator, the geometric parameter of pin hole or the line of rabbet joint includes: position on described collimator of described pin hole or the line of rabbet joint and subtended angle.
6. the geometry scale method of single photon emission computed tomography (SPECT) system according to claim 1, it is characterized in that, in the following way described collimator is measured to obtain the geometric parameter of pin hole or the line of rabbet joint on described collimator: mechanical measuring means, measuring method, imaging measurement method, method for electromagnetically measuring or Pneumatic Measuring Method of Coupled Pair.
7. the geometry scale method of single photon emission computed tomography (SPECT) system according to claim 1, it is characterized in that, described collimator be shaped as ring-type, tabular or polygon, the pin hole of described collimator is circular cone, elliptic cone, round platform, elliptical table, polygonal pyramid or many terrace with edges.
8. the geometry scale method of single photon emission computed tomography (SPECT) system according to claim 7, it is characterised in that described pet detector is and the annular detector of described collimator adaptation, flat panel detector or polygon detector.
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| CN104614758B (en) * | 2015-02-17 | 2017-03-29 | 四川中测辐射科技有限公司 | Two-way detector array scale method and system |
| CN104732540B (en) * | 2015-03-27 | 2017-11-17 | 北京永新医疗设备有限公司 | PET/CT geometrical registration method and systems |
| CN104783829B (en) * | 2015-04-29 | 2017-07-14 | 北京永新医疗设备有限公司 | The processing method and system of single photon emission tomographic imaging |
| CN106556857B (en) * | 2016-10-19 | 2019-04-02 | 武汉中派科技有限责任公司 | Response location localization method and device |
| CN106859685B (en) * | 2017-01-05 | 2020-05-19 | 东软医疗系统股份有限公司 | Image reconstruction method, device and equipment |
| CN107133462B (en) * | 2017-04-27 | 2020-08-18 | 上海联影医疗科技有限公司 | Data processing method, device and equipment |
| CN107390253B (en) * | 2017-07-18 | 2019-04-30 | 北京永新医疗设备有限公司 | Single photon emission tomographic imaging equipment Quality Control scaling method and system |
| CN108309339B (en) * | 2018-01-26 | 2020-11-06 | 北京科技大学 | SPECT/PET/MRI three-mode imaging system and method |
| CN109738439B (en) * | 2019-01-02 | 2021-04-13 | 中国工程物理研究院材料研究所 | Solid angle differential imaging collimator and application thereof |
| CN109646035B (en) * | 2019-01-04 | 2022-04-22 | 北京永新医疗设备有限公司 | Bone tomographic image reconstruction method and system |
| CN110232032B (en) * | 2019-07-22 | 2022-02-11 | 东软医疗系统股份有限公司 | Data acquisition system and method |
| CN112450959B (en) * | 2020-12-08 | 2023-08-15 | 鲁东大学 | Single-mode PET imaging system and method capable of realizing accurate positioning |
| CN112932513A (en) * | 2021-01-27 | 2021-06-11 | 北京科技大学 | Medical imaging system |
| CN113712584B (en) * | 2021-09-30 | 2024-06-18 | 上海联影医疗科技股份有限公司 | PET scanning method, device, electronic device and storage medium |
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| CN102008314B (en) * | 2010-12-17 | 2012-11-14 | 清华大学 | Collimator device for small animal imaging |
| CN103181773A (en) * | 2011-10-09 | 2013-07-03 | 明峰医疗系统股份有限公司 | Tomographic imaging system for acquiring pet/spect and ct image data |
| CN202886612U (en) * | 2012-08-08 | 2013-04-17 | 北京辛耕普华医疗科技有限公司 | Collimator for gamma radioactive-source position indicator |
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