CN203763057U - Image registration device of multi-mode imaging system - Google Patents
Image registration device of multi-mode imaging system Download PDFInfo
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- CN203763057U CN203763057U CN201420121221.XU CN201420121221U CN203763057U CN 203763057 U CN203763057 U CN 203763057U CN 201420121221 U CN201420121221 U CN 201420121221U CN 203763057 U CN203763057 U CN 203763057U
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- 239000003795 chemical substances by application Substances 0.000 claims abstract description 87
- 238000012360 testing method Methods 0.000 claims abstract description 76
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- 239000012780 transparent material Substances 0.000 claims abstract description 4
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims description 29
- 238000007689 inspection Methods 0.000 claims description 4
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- 239000007924 injection Substances 0.000 description 2
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- 210000004080 milk Anatomy 0.000 description 2
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Abstract
The utility model discloses an image registration device of a multi-mode imaging system. The image registration device comprises a positioning base, a closed cavity, a test tube and a sealing cover, wherein the closed cavity is fixed on one side wall of the positioning base, the test tube is a thin tube with one open end, a developing agent is filled in the test tube, the test tube is placed in the closed cavity, and the axis of the test tube is parallel to a detection axis. The sealing cover seals the closed cavity, and a medium is filled in the inside during FMT registration. The positioning base is made of a non-transparent material. The closed cavity and the test tube are made of a transparent material. The image registration device is based on rigid body registration, simple in parameter, high in registration accuracy and capable of flexibly and accurately achieving any two-mode, three-mode and four-mode combined registration in a four-mode imaging device and especially improves the accuracy of FMT and other mode image registration.
Description
Technical field
This utility model relates to biomedical imaging field, relates in particular to a kind of registration apparatus for multi-mode imaging system image registration.
Background technology
Medical imaging technology is that the essence that realizes noinvasive, high sensitivity, high-resolution detection life under condition of living organism has been brought into play important function.But due to the complexity of organism itself, any single image mode all cannot dissect bioprocess completely.Therefore, multi-modal medical imaging technology is once proposing just to have obtained development rapidly.It combines multiple image modes advantage separately, and prior information can be provided mutually, and imaging results can be provided more comprehensively, more accurately, more reliably.For example computerized tomography CT can provide the anatomic information of organism exactly.Positron emission computerized tomography PET, single photon emission computerized tomography SPECT and fluorescent molecular tomography FMT can provide the function informations such as molecule metabolism.Meanwhile, the fusion of mode is as utilized the priori structural information of CT also can improve the reconstruction precision of FMT.
In multi-mode imaging system, each imaging device has coordinate system separately, due to the coordinate system difference that each imaging device adopts, causes the position difference of same check point in visual field FOV, so just multi-modality images cannot be merged.Therefore need first the image of different mode to be mated, make the image under different imaging patterns, same position being formed in identical within sweep of the eye position, this process is just called " registration ".Due to multiple image mode generating principle difference separately, the common information between each mode is little.Therefore the registration of the imaging results of multiple modalities, becomes the committed step of multi-modality imaging successful Application.At present, the multi-mode imaging systems such as PET/CT or SPECT/CT are commercial, and corresponding method for registering and registration model also obtain research and development.Within 2012, Peking University appoints real leader's of autumn research group to realize first CT/PET/SPECT/FMT tetra-mode imaging systems, but not yet has suitable apparatus and method to be applicable to the registration of four mode at present.In addition, FMT, as a kind of emerging imaging device, not yet proposes in the industry the apparatus and method of a kind of accurate FMT and other mode registrations.
Utility model content
In order to realize the image registration of multi-mode imaging system (CT/PET/SPECT/FMT), this utility model provides a kind of image registration device that is applicable to four mode imaging systems.
The purpose of this utility model is to provide a kind of image registration device of multi-mode imaging system.
The image registration device of multi-mode imaging system of the present utility model comprises: positioning pedestal, closed cavity, test tube and seal cover; Wherein, closed cavity is fixed on a sidewall of positioning pedestal; Test tube is the tubule of an end opening, is wherein marked with developing agent, be placed in closed cavity, and the axis of test tube is parallel to inspection axle; Seal cover seals closed cavity, and in the time using developing agent to carry out image registration to FMT, inside is full of medium; Positioning pedestal adopts opaque material; Closed cavity and test tube adopt transparent material.
Positioning pedestal is used for fixing and supports closed cavity, and in the time of CT image registration and FMT image registration, positioning pedestal is carried out to imaging, realizes image registration by the two dimensional image comparison of positioning pedestal.Therefore, positioning pedestal adopts lighttight material, and the shape of positioning pedestal is for checking that axle is non-centrosymmetry.
For functional imaging PET, SPECT and FMT, need to inject developing agent and just can be embodied as picture.In test tube, inject developing agent, to the position imaging of developing agent, thereby be used for realizing the image registration of the functional imaging corresponding with developing agent.In order to improve the degree of accuracy of registration, adopt multiple test tubes, thereby can, by the comparison of multiple different image spaces, realize registration.On seal cover, be provided with the through hole matching with test tube, test tube is fixed on the inside of closed cavity by through hole.The diameter of through hole is identical with the external diameter of test tube, and the number of through hole is identical with the number of test tube.The diameter of test tube is not less than 1mm.
In the time carrying out FMT registration, closed cavity inside is full of medium, and the scattering of medium is identical with measured body with absorptance, to simulate the optical environment of FMT.
The method for registering images of multi-mode imaging system of the present utility model, comprises the image registration of bimodal, three mode and four mode.
Bimodal image method for registering of the present utility model comprises following four kinds of situations:
A) image registration of functional imaging PET or SPECT and structure imaging CT, comprises the following steps:
1) by the developing agent injecting tube of corresponding function imaging PET or SPECT, test tube is inserted in closed cavity, fix by seal cover, and closed cavity is sealed;
2) by CT and corresponding functional imaging bimodal combination, developing agent is carried out to imaging;
3) the image characteristic information extraction of developing agent bimodal being detected jointly, mates and image co-registration, realizes bimodal image registration.
B) image registration of functional imaging PET and SPECT, comprises the following steps:
1) will after PET and the mixing of SPECT developing agent, be injected in test tube, and test tube is inserted in closed cavity, fix by seal cover, and closed cavity is sealed;
2) combine developing agent imaging respectively by PET and SPECT bimodal;
3) the bimodal developing agent of PET and SPECT is at same position, and the image characteristic information extraction of the developing agent that bimodal is obtained separately, mates and image co-registration, realizes bimodal image registration.
C) image registration of functional imaging PET or SPECT and FMT:
1) be injected in test tube after FMT is mixed with the developing agent of PET or SPECT, and test tube is inserted in closed cavity, medium is full of to closed cavity and is sealed to simulate the optical environment of FMT by seal cover, fix test tube by seal cover simultaneously;
2) use FMT and PET or the combination of SPECT bimodal to developing agent imaging respectively;
3) the bimodal developing agent of FMT and PET or SPECT is at same position, and the image characteristic information extraction of the developing agent that bimodal is obtained separately, mates and image co-registration, realizes bimodal image registration.
D) image registration of FMT and CT, comprises following two kinds of methods:
First method, comprises the following steps:
1) by the developing agent injecting tube of FMT, and test tube is inserted in closed cavity, medium is full of to closed cavity and is sealed to simulate the optical environment of FMT by seal cover, fix test tube by seal cover simultaneously;
2) by CT and the combination of FMT bimodal, developing agent is carried out to imaging;
3) the image characteristic information extraction of developing agent bimodal being detected jointly, mates and image co-registration, realizes bimodal image registration.
Second method, the precision of rebuilding image due to FMT is lower, directly utilizes the reconstructed results of FMT to mate, and may strengthen registration error; For improving the image registration accuracy of FMT and CT, can select to adopt about checking that the non-centrosymmetrical positioning pedestal of axle carries out registration, comprises the following steps:
1) positioning pedestal is taken pictures from multiple angles by FMT mode, obtain two-dimentional white light figure;
2) by CT mode, positioning pedestal is carried out to imaging, obtain projection;
3) utilize the two-dimentional white light figure of FMT and the projection of CT to extract the characteristic informations such as profile, mate and image co-registration,
Realize bimodal image registration.
Three mode method for registering images of the present utility model comprise following three kinds of situations:
A) image registration of PET, SPECT and FMT tri-mode, comprises the following steps:
1) will after the developing agent mixing of PET, SPECT and FMT, be injected in test tube, and test tube is inserted in closed cavity, medium is full of to closed cavity and is sealed to simulate the optical environment of FMT by seal cover, fix test tube by seal cover simultaneously; 2) combine developing agent imaging respectively by PET, SPECT and FMT tri-mode;
3) developing agent of PET, SPECT and FMT tri-mode is at same position, and the image characteristic information extraction of the developing agent that three mode are obtained separately, mates and image co-registration, realizes three mode image registrations.
B) image registration of PET, SPECT and CT tri-mode, comprises the following steps:
1) PET and SPECT developing agent are injected in test tube, the position of injection can be the same or different, and by test tube
Insert in closed cavity, fix test tube and closed cavity is sealed by seal cover;
2) by PET, SPECT and CT tri-mode combinations, developing agent is carried out to imaging;
3) image of developing agent PET, SPECT and CT tri-mode being detected, characteristic information extraction respectively, mate respectively taking CT as benchmark with image co-registration after, thereby obtain three mode image registrations.
Especially for CT PET in SPECT tri-mode imaging systems, if SPECT device can not shield the radioactivity of PET developing agent, for fear of the radiological effect SPECT imaging of PET developing agent, should be noted that the developing agent of SPECT and the developing agent injecting tube of PET and the order of imaging, specifically adopt following steps:
1) first the developing agent of SPECT is injected in test tube, and test tube is inserted in closed cavity, fix examination by seal cover
Pipe is also by closed cavity sealing, then by SPECT mode to developing agent imaging;
2) again the developing agent of PET is injected in test tube, and test tube is inserted in closed cavity, fix test tube and by closed cavity sealing by seal cover, then by PET mode to developing agent imaging; Or,
1) first the developing agent of PET is injected in test tube, and test tube is inserted in closed cavity, fix test tube and by closed cavity sealing by seal cover, then by phase PET mode to developing agent imaging;
2) etc. PET developing agent decays to and does not affect after SPECT imaging, then the developing agent of SPECT is injected in test tube, and test tube is inserted in closed cavity, fixes test tube and by closed cavity sealing by seal cover, then by SPECT mode to developing agent imaging;
3) by CT mode, the developing agent of SPECT and PET is carried out to imaging;
4) image of developing agent PET, SPECT and CT tri-mode being detected, characteristic information extraction respectively, taking CT as
Benchmark mate respectively and image co-registration after, thereby obtain three mode image registrations.C) image registration of FMT, CT and PET or SPECT tri-mode, comprises following two kinds of methods:
First method, comprises the following steps:
1) developing agent of FMT and PET or SPECT is injected in vitro, can be injected into same position or diverse location, and test tube is inserted in closed cavity, medium is full of to closed cavity and is sealed to simulate the optical environment of FMT by seal cover, fix test tube by seal cover simultaneously;
2) utilize FMT, CT and PET or SPECT tri-mode combinations to carry out imaging to developing agent;
3) image of developing agent FMT, CT and PET or SPECT tri-mode being detected, characteristic information extraction respectively,
Mate respectively taking CT as benchmark and image co-registration after, thereby obtain three mode image registrations.
Second method, comprises the following steps:
1) by the bottom of the developing agent injecting tube of corresponding function imaging PET or SPECT, test tube is inserted in closed cavity, fix by seal cover, and closed cavity is sealed;
2) utilize CT and PET or SPECT bimodal to carry out imaging to developing agent;
3) the image characteristic information extraction of developing agent bimodal being detected jointly, mates and image co-registration, obtains the image registration of CT and PET or SPECT;
4) positioning pedestal is taken pictures from multiple angles by FMT device, obtain two-dimentional white light figure;
5) by CT device, positioning pedestal is carried out to imaging, obtain projection;
6) the two-dimentional white light figure to FMT and the projection characteristic information extraction of CT, mate and image co-registration, by FMT and CT registration, thereby obtains three mode image registrations taking CT as benchmark.
Four mode method for registering images of the present utility model comprise following two kinds of methods:
First method, comprises the following steps:
1) developing agent of FMT, PET and SPECT is injected in vitro, can be injected into same position or diverse location, and test tube is inserted in closed cavity;
2) medium be full of to closed cavity and sealed to simulate the optical environment of FMT by seal cover, fixing test tube by seal cover simultaneously;
3) utilize FMT, CT, PET and SPECT to carry out imaging to developing agent;
4) the image characteristic information extraction of developing agent CT, FMT, PET and SPECT tetra-mode being detected, thus mate respectively taking CT as benchmark and image co-registration after obtain four mode image registrations.
Second method, comprises the following steps:
1) positioning pedestal is taken pictures from multiple angles by FMT device, obtain two-dimentional white light figure;
2) by CT device, positioning pedestal is carried out to imaging, obtain projection;
3) projection of the two-dimentional white light figure to FMT and CT extracts the characteristic informations such as profile, mates and image co-registration, obtains the image registration of FMT and CT;
4) PET and SPECT developing agent are injected in test tube, the position of injection can be the same or different, and test tube is inserted in closed cavity, is fixed test tube and closed cavity is sealed by seal cover;
5) by PET, SPECT and CT, developing agent is carried out to imaging;
6) the image characteristic information extraction of developing agent PET, SPECT and CT tri-mode being detected, thus mate respectively taking CT as benchmark and image co-registration after obtain three mode image registrations;
7) utilize step 3) and 6) parameter that obtains, taking CT as benchmark, can realize coupling and the image co-registration of four mode.Especially for CT PET SPECT in FMT tetra-mode imaging systems, if SPECT device can not shield the radioactivity of PET developing agent, for fear of the radiological effect SPECT imaging of PET developing agent, should be noted that the developing agent of SPECT and the developing agent injecting tube of PET and the order of imaging, specifically adopt following steps:
1) first by SPECT PET a kind of developing agent in FMT be injected in test tube, and test tube is inserted in closed cavity, logical
Cross the fixing test tube of seal cover and by closed cavity sealing, then by corresponding mode to developing agent imaging;
2) again according to 1) method complete successively other two kinds of mode to the imaging of developing agent separately, if before PET is imaged on SPECT imaging, waiting PET developing agent to decay to does not affect after SPECT imaging, then the developing agent of SPECT is injected in test tube, then carries out SPECT imaging;
3) by CT mode, the developing agent of SPECT, PET and FMT is carried out to imaging;
4) image of developing agent FMT, PET, SPECT and CT tetra-mode being detected, respectively characteristic information extraction, mate respectively taking CT as benchmark with image co-registration after, thereby obtain four mode image registrations.
In addition, adopt the method for registering images of bimodal arbitrarily or three mode, by after mutual two or three in four mode image registration, in the image registration of carrying out remaining mode, thereby realize four mode image registrations.
Advantage of the present utility model:
This utility model is based on rigid registration, and parameter is relatively simple, and registration accuracy is high, and can realize flexibly, accurately the image registration that in four mode imaging devices, two, three and four mode combine arbitrarily, has especially improved the precision of FMT and other mode image registrations.
Brief description of the drawings
Fig. 1 is the structural representation of multi-mode imaging system;
Fig. 2 is the structural representation of an embodiment of the image registration device of multi-mode imaging system of the present utility model;
Fig. 3 (a, b) is the schematic diagram of the seal cover of an embodiment of the image registration device of multi-mode imaging system of the present utility model.
Detailed description of the invention
Below in conjunction with accompanying drawing, by example, this utility model is described further.
As shown in Figure 1, four mode imaging systems comprise: fluorescence tomography FMT device 01, positron emission tomography PET device 02, computer tomography CT device 03, single photon emission tomographic imaging SPECT device 04, rotary apparatus 05, detection bed apparatus 06 and data acquisition unit and computer; Each imaging device through data wire by data acquisition unit Sampling hold to computer; Each imaging device shares an examinating couch device and same inspection axle; Wherein: CT device and SPECT device are arranged on a rotary apparatus 05, form CT/SPECT device, FMT device is arranged on another rotary frame device; Detect one end that bed apparatus 06 is arranged on base 07, FMT device 01, PET device 02, CT device 03 and SPECT device 04 are arranged on respectively the other end of base 07 successively, and each device is positioned on same axis, detect bed apparatus 06 and comprise elevating mechanism 063, translation mechanism 062 and examinating couch 061, elevating mechanism 063 is on base 07, translation mechanism peace 062 is contained on elevating mechanism 063, and examinating couch 061 is arranged on translation mechanism 062, as shown in Figure 1.
As shown in Figure 2, the image registration device of the multi-mode imaging system of the present embodiment comprises: positioning pedestal 1, closed cavity 2, test tube 3 and seal cover 4; Wherein, closed cavity 2 is fixed on a sidewall of positioning pedestal 1; Test tube 3 is the tubule of an end opening, is wherein marked with developing agent, be placed in closed cavity 2, and the axis of test tube 3 is parallel to inspection axle; Seal cover 4 seals closed cavity 2, and in the time carrying out FMT registration, inside is full of medium.
Positioning pedestal 1, for about checking that axle is asymmetrical cuboid, adopts opaque nylon in the present embodiment; Closed cavity 2 is columniform transparent organic glass, is fixed on the sidewall of positioning pedestal 1 by the mode of bonding or screw thread; Test tube 3 adopts glass tubule, and 3 test tubes are fixed in closed cavity 2 by the through hole matching on seal cover 4; 3 through holes 41 are set on seal cover 4, and the diameter of through hole equals the external diameter of test tube; While carrying out FMT image registration, in closed cavity 2, be full of fat milk and sealed to simulate the optical environment of FMT by seal cover.
Adopt 3 test tubes seal cover schematic diagram as shown in Figure 3, the positional alignment of 3 through holes 42 can be being positioned on straight line in Fig. 3 (a), also can as in Fig. 3 (b) about centrosymmetry.
Taking two kinds of methods of four mode image registrations as example, illustrate the method for registering images of multi-modality images of the present utility model below.
The first method for registering images, comprises the following steps:
1) by SPECT developing agent
99mTc, PET developing agent
18in F and FMT developing agent ICG injecting tube 3, due to different test tubes in visual field FOV in different positions, there is its typical meaning each position, therefore 3 test tubes is all injected to developing agent, and test tube is inserted in closed cavity;
2) preparation fat milk is full of closed cavity, and is sealed to simulate the optical environment of FMT by seal cover, fixes test tube by seal cover simultaneously;
3) utilize corresponding PET, SPECT, FMT and CT device to carry out imaging to developing agent, because the density of the density of functional imaging mode developing agent used and designed image matching apparatus has difference, CT can distinguish and characteristic information extractions developing agent and test tube 3, and other three mode are only to developing agent video picture separately;
4) image of the developing agent that PET, SPECT and FMT tri-mode detect, the image characteristic information extraction of the developing agent arriving with CT mode detection respectively, characteristic information comprises the information such as profile or angle point, mates and image co-registration, realizes four mode image registrations.
The image detecting under different mode, utilizes the characteristic information such as profile or angle point to obtain rotary flat shifting parameter, and is used for the image that correcting multi-modality detects using this as registration parameter.
Second method, comprises the following steps:
1) by FMT device, positioning pedestal 1 is carried out to 360 degree and take pictures, every acquisition of 5 degree totally 72 two-dimentional white light figure;
2) by CT device, positioning pedestal 1 is carried out to imaging, obtain three dimensional CT figure;
3) the three dimensional CT figure of positioning pedestal 1 is carried out to multi-angle projection and obtain two-dimension projection, utilize two-dimension projection and white light
Figure carries out proportioning and image co-registration, thereby obtains corresponding image registration parameter and realize the image registration of FMT and CT;
4) by SPECT developing agent
99mtc and PET developing agent
18in F injecting tube 3, because different thin glass tubes is becoming
In the picture visual field, in different positions, there is its typical meaning each position, therefore 3 test tubes are all injected to developing agent;
5) by PET and SPECT, developing agent is separately carried out to imaging, meanwhile, due to functional imaging mode developing agent used
Density and designed device density have difference, can carry out imaging, differentiation and characteristic information extraction to two kinds of developing agents with CT;
6) image of the developing agent that PET and SPECT mode detect, the image of the developing agent detecting with CT mode respectively
Carry out characteristic information extraction, mate and image co-registration after realize the image registration of PET, SPECT and CT;
7) utilize step 3) and 6) parameter that obtains, taking CT as benchmark, mate and image co-registration, can realize four moulds
State image registration.
Finally it should be noted that, the object of publicizing and implementing mode is to help further to understand this utility model, but it will be appreciated by those skilled in the art that: not departing from the spirit and scope of this utility model and appended claim, various substitutions and modifications are all possible.Therefore, this utility model should not be limited to the disclosed content of embodiment, and the scope that the claimed scope of this utility model defines with claims is as the criterion.
Claims (6)
1. an image registration device for multi-mode imaging system, is characterized in that, described image registration device comprises: positioning pedestal (1), closed cavity (2), test tube (3) and seal cover (4); Wherein, described closed cavity (2) is fixed on a sidewall of positioning pedestal (1); Described test tube (3) is the tubule of an end opening, is wherein marked with developing agent, be placed in closed cavity (2), and the axis of test tube (3) is parallel to inspection axle; Described seal cover (4) is by closed cavity (2) sealing, and in the time using developing agent to carry out image registration to FMT, inside is full of medium; Described positioning pedestal (1) adopts opaque material; Described closed cavity (2) and test tube (3) adopt transparent material.
2. image registration device as claimed in claim 1, is characterized in that, the shape of described positioning pedestal (1) is for checking that axle is non-centrosymmetry.
3. image registration device as claimed in claim 1, is characterized in that, is provided with the through hole (41) matching with test tube (3) on described seal cover (4), and described test tube (3) is fixed on the inside of closed cavity (2) by through hole (41).
4. image registration device as claimed in claim 3, is characterized in that, the diameter of described through hole (41) is identical with the external diameter of test tube, and the number of through hole is identical with the number of test tube.
5. image registration device as claimed in claim 1, is characterized in that, the scattering of described medium is identical with measured body with absorptance.
6. image registration device as claimed in claim 1, is characterized in that, the diameter of described test tube (3) is not less than 1mm.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201420121221.XU CN203763057U (en) | 2014-03-18 | 2014-03-18 | Image registration device of multi-mode imaging system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420121221.XU CN203763057U (en) | 2014-03-18 | 2014-03-18 | Image registration device of multi-mode imaging system |
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| CN203763057U true CN203763057U (en) | 2014-08-13 |
Family
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103815928A (en) * | 2014-03-18 | 2014-05-28 | 北京大学 | Image registration device and method for multi-model imaging system |
| CN108135565A (en) * | 2015-10-09 | 2018-06-08 | 因赛泰克有限公司 | For being registrated the image system and method that simultaneously authentication image is registrated obtained using various image modes |
-
2014
- 2014-03-18 CN CN201420121221.XU patent/CN203763057U/en not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103815928A (en) * | 2014-03-18 | 2014-05-28 | 北京大学 | Image registration device and method for multi-model imaging system |
| CN103815928B (en) * | 2014-03-18 | 2015-11-04 | 北京大学 | A kind of image registration device of multi-mode imaging system and method for registering thereof |
| CN108135565A (en) * | 2015-10-09 | 2018-06-08 | 因赛泰克有限公司 | For being registrated the image system and method that simultaneously authentication image is registrated obtained using various image modes |
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