CN104169275B - 用作激酶抑制剂的三唑取代的吡啶化合物 - Google Patents
用作激酶抑制剂的三唑取代的吡啶化合物 Download PDFInfo
- Publication number
- CN104169275B CN104169275B CN201380013640.XA CN201380013640A CN104169275B CN 104169275 B CN104169275 B CN 104169275B CN 201380013640 A CN201380013640 A CN 201380013640A CN 104169275 B CN104169275 B CN 104169275B
- Authority
- CN
- China
- Prior art keywords
- solvent
- acn
- isopropylamino
- pyridin
- retention time
- Prior art date
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- Expired - Fee Related
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- 0 Nc1cc(N=C*2)c2cc1 Chemical compound Nc1cc(N=C*2)c2cc1 0.000 description 10
- YXBSPEDTBVJVAY-UHFFFAOYSA-N C1=CN=[I]C=C1 Chemical compound C1=CN=[I]C=C1 YXBSPEDTBVJVAY-UHFFFAOYSA-N 0.000 description 1
- FMIYUKBRIPHXTI-WAYWQWQTSA-N C=C/C=C\NC=C Chemical compound C=C/C=C\NC=C FMIYUKBRIPHXTI-WAYWQWQTSA-N 0.000 description 1
- KZPSPKJOYAPXIR-UHFFFAOYSA-N C=CCNc1cc(Cl)ncc1-c1nc(C(O)=O)c[s]1 Chemical compound C=CCNc1cc(Cl)ncc1-c1nc(C(O)=O)c[s]1 KZPSPKJOYAPXIR-UHFFFAOYSA-N 0.000 description 1
- JSADXPHJQCCHLN-ZDUSSCGKSA-N CC(C)Nc(cc(Nc1cc2n[s]nc2cc1)nc1)c1-c1nnc(C(N(CC2)C[C@H]2O)=O)[s]1 Chemical compound CC(C)Nc(cc(Nc1cc2n[s]nc2cc1)nc1)c1-c1nnc(C(N(CC2)C[C@H]2O)=O)[s]1 JSADXPHJQCCHLN-ZDUSSCGKSA-N 0.000 description 1
- WKZRODSIPZVFDQ-UHFFFAOYSA-N CC(C)Nc(cc(Nc1ccc2nc[s]c2c1)nc1)c1-c1cnc[o]1 Chemical compound CC(C)Nc(cc(Nc1ccc2nc[s]c2c1)nc1)c1-c1cnc[o]1 WKZRODSIPZVFDQ-UHFFFAOYSA-N 0.000 description 1
- LTPHABUONTVSMY-UHFFFAOYSA-N CC(C)Nc(cc(Nc1ccc2nc[s]c2c1)nc1)c1-c1nc(C(C)=O)c(C)[s]1 Chemical compound CC(C)Nc(cc(Nc1ccc2nc[s]c2c1)nc1)c1-c1nc(C(C)=O)c(C)[s]1 LTPHABUONTVSMY-UHFFFAOYSA-N 0.000 description 1
- GVEJPAHQTPJBEZ-UHFFFAOYSA-N CC(C)Nc(cc(Nc1ccc2nc[s]c2c1)nc1)c1-c1nc(N(C(C)=O)C(OC(C)(C)C)=O)c(C)[o]1 Chemical compound CC(C)Nc(cc(Nc1ccc2nc[s]c2c1)nc1)c1-c1nc(N(C(C)=O)C(OC(C)(C)C)=O)c(C)[o]1 GVEJPAHQTPJBEZ-UHFFFAOYSA-N 0.000 description 1
- CBUCTFVPFDVFSU-UHFFFAOYSA-N CC(C)Nc(cc(Nc1ccc2nc[s]c2c1)nc1)c1-c1nnc(C(CO)NS(C)(=O)=O)[o]1 Chemical compound CC(C)Nc(cc(Nc1ccc2nc[s]c2c1)nc1)c1-c1nnc(C(CO)NS(C)(=O)=O)[o]1 CBUCTFVPFDVFSU-UHFFFAOYSA-N 0.000 description 1
- LXPRJDMMMSEHQG-UHFFFAOYSA-N CC(C)Nc1cc(Cl)ncc1-c1nc(C(O)=O)c(C)[s]1 Chemical compound CC(C)Nc1cc(Cl)ncc1-c1nc(C(O)=O)c(C)[s]1 LXPRJDMMMSEHQG-UHFFFAOYSA-N 0.000 description 1
- DVIAFXIRVDBBFQ-UHFFFAOYSA-N CC(C)Nc1cc(Cl)ncc1C(NC(CO)C(OC)=O)=O Chemical compound CC(C)Nc1cc(Cl)ncc1C(NC(CO)C(OC)=O)=O DVIAFXIRVDBBFQ-UHFFFAOYSA-N 0.000 description 1
- UNUSCOSCJACYLL-UHFFFAOYSA-N CC(C)Nc1cc(Nc2ccc3nc[s]c3c2)ncc1-c1nnc(C(N(CC2)CC2NS(C)(=O)=O)=O)[s]1 Chemical compound CC(C)Nc1cc(Nc2ccc3nc[s]c3c2)ncc1-c1nnc(C(N(CC2)CC2NS(C)(=O)=O)=O)[s]1 UNUSCOSCJACYLL-UHFFFAOYSA-N 0.000 description 1
- YYRRNJVZTIDJOM-SREVYHEPSA-N CCC/C=N\OC=C Chemical compound CCC/C=N\OC=C YYRRNJVZTIDJOM-SREVYHEPSA-N 0.000 description 1
- NPTVZUXYHNHOJK-UHFFFAOYSA-N CCOC(c(c(NC(C)C)c1)cnc1Cl)=O Chemical compound CCOC(c(c(NC(C)C)c1)cnc1Cl)=O NPTVZUXYHNHOJK-UHFFFAOYSA-N 0.000 description 1
- NQPWPRGYGNULNY-CYBMUJFWSA-N CNC(c(cc1)ccc1Nc1cc(Cl)ncc1-c1nnc(C(N(CC2)C[C@@H]2O)=O)[s]1)=O Chemical compound CNC(c(cc1)ccc1Nc1cc(Cl)ncc1-c1nnc(C(N(CC2)C[C@@H]2O)=O)[s]1)=O NQPWPRGYGNULNY-CYBMUJFWSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261586139P | 2012-01-13 | 2012-01-13 | |
| US61/586,139 | 2012-01-13 | ||
| PCT/US2013/021096 WO2013106614A1 (en) | 2012-01-13 | 2013-01-11 | Triazolyl-substituted pyridyl compounds useful as kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104169275A CN104169275A (zh) | 2014-11-26 |
| CN104169275B true CN104169275B (zh) | 2017-06-09 |
Family
ID=47595098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380013640.XA Expired - Fee Related CN104169275B (zh) | 2012-01-13 | 2013-01-11 | 用作激酶抑制剂的三唑取代的吡啶化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8987311B2 (enExample) |
| EP (1) | EP2802577B1 (enExample) |
| JP (1) | JP6096807B2 (enExample) |
| CN (1) | CN104169275B (enExample) |
| ES (1) | ES2630705T3 (enExample) |
| WO (1) | WO2013106614A1 (enExample) |
Families Citing this family (62)
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| ES2686500T3 (es) | 2012-01-13 | 2018-10-18 | Bristol-Myers Squibb Company | Compuestos de piridilo sustituidos con heterocíclicos, útiles como inhibidores de cinasas |
| EP2802579B1 (en) * | 2012-01-13 | 2016-04-13 | Bristol-Myers Squibb Company | Thiazolyl- or thiadiazolyl-substituted pyridyl compounds useful as kinase inhibitors |
| US9598440B2 (en) | 2012-10-08 | 2017-03-21 | Merck Sharp & Dohme Corp. | Inhibitors of IRAK4 activity |
| AU2013341200A1 (en) | 2012-11-08 | 2015-07-02 | Bristol-Myers Squibb Company | Heteroaryl substituted pyridyl compounds useful as kinase modulators |
| CN104781251B (zh) * | 2012-11-08 | 2016-12-14 | 百时美施贵宝公司 | 可作为激酶调节剂的经双环杂环取代的吡啶基化合物 |
| GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| TWI667233B (zh) | 2013-12-19 | 2019-08-01 | 德商拜耳製藥公司 | 新穎吲唑羧醯胺，其製備方法、含彼等之醫藥製劑及其製造醫藥之用途 |
| TW201609693A (zh) | 2014-01-03 | 2016-03-16 | 必治妥美雅史谷比公司 | 雜芳基取代之菸鹼醯胺化合物 |
| US20180228907A1 (en) | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| MA42145B1 (fr) | 2015-05-20 | 2020-05-29 | Amgen Inc | Triazoles agonistes du récepteur apj |
| TW201713655A (zh) | 2015-06-24 | 2017-04-16 | 必治妥美雅史谷比公司 | 經雜芳基取代之胺基吡啶化合物 |
| CN107849039B (zh) * | 2015-06-24 | 2020-07-03 | 百时美施贵宝公司 | 经杂芳基取代的氨基吡啶化合物 |
| EP3313844B1 (en) | 2015-06-24 | 2020-08-26 | Bristol-Myers Squibb Company | Heteroaryl substituted aminopyridine compounds |
| EP3452466B1 (en) | 2016-05-03 | 2020-08-12 | Amgen Inc. | Heterocyclic triazole compounds as agonists of the apj receptor |
| CN106222183B (zh) * | 2016-07-25 | 2019-11-08 | 南通大学 | 靶向人irak1基因的小干扰rna及其应用 |
| TWI763722B (zh) * | 2016-10-14 | 2022-05-11 | 美商林伯士拉克許米公司 | Tyk2抑制劑及其用途 |
| EP3541792B1 (en) | 2016-11-16 | 2020-12-23 | Amgen Inc. | Triazole furan compounds as agonists of the apj receptor |
| EP3541803B1 (en) | 2016-11-16 | 2020-12-23 | Amgen Inc. | Triazole pyridyl compounds as agonists of the apj receptor |
| EP3541802B1 (en) | 2016-11-16 | 2025-01-01 | Amgen Inc. | Alkyl substituted triazole compounds as agonists of the apj receptor |
| US11046680B1 (en) | 2016-11-16 | 2021-06-29 | Amgen Inc. | Heteroaryl-substituted triazoles as APJ receptor agonists |
| US10906890B2 (en) | 2016-11-16 | 2021-02-02 | Amgen Inc. | Triazole phenyl compounds as agonists of the APJ receptor |
| WO2018093577A1 (en) | 2016-11-16 | 2018-05-24 | Amgen Inc. | Cycloalkyl substituted triazole compounds as agonists of the apj receptor |
| TW202340194A (zh) | 2017-02-16 | 2023-10-16 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒𠯤衍生物 |
| CA3062602A1 (en) | 2017-05-11 | 2018-11-15 | Bristol-Myers Squibb Company | Thienopyridines and benzothiophenes useful as irak4 inhibitors |
| WO2019060693A1 (en) | 2017-09-22 | 2019-03-28 | Kymera Therapeutics, Inc. | CRBN LIGANDS AND USES THEREOF |
| MX2020003190A (es) | 2017-09-22 | 2020-11-11 | Kymera Therapeutics Inc | Degradadores de proteinas y usos de los mismos. |
| WO2019089335A1 (en) | 2017-11-03 | 2019-05-09 | Amgen Inc. | Fused triazole agonists of the apj receptor |
| US11065231B2 (en) | 2017-11-17 | 2021-07-20 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides |
| WO2019111218A1 (en) | 2017-12-08 | 2019-06-13 | Cadila Healthcare Limited | Novel heterocyclic compounds as irak4 inhibitors |
| WO2019126731A1 (en) | 2017-12-22 | 2019-06-27 | Petra Pharma Corporation | Aminopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors |
| IL315310A (en) | 2017-12-26 | 2024-10-01 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| EP3737666A4 (en) | 2018-01-12 | 2022-01-05 | Kymera Therapeutics, Inc. | PROTEIN DEGRADATION AGENTS AND ASSOCIATED USES |
| US11512080B2 (en) | 2018-01-12 | 2022-11-29 | Kymera Therapeutics, Inc. | CRBN ligands and uses thereof |
| CN110317190A (zh) * | 2018-03-28 | 2019-10-11 | 首都医科大学 | 一种三唑-羧酸酯类衍生物在医药领域的应用 |
| EP3788037A1 (en) | 2018-05-01 | 2021-03-10 | Amgen Inc. | Substituted pyrimidinones as agonists of the apj receptor |
| US12454520B2 (en) | 2018-07-06 | 2025-10-28 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| US11292792B2 (en) | 2018-07-06 | 2022-04-05 | Kymera Therapeutics, Inc. | Tricyclic CRBN ligands and uses thereof |
| TWI721483B (zh) | 2018-07-13 | 2021-03-11 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒𠯤衍生物 |
| AU2019389174A1 (en) | 2018-11-30 | 2021-07-01 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| TW202112767A (zh) | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物 |
| PH12022500002A1 (en) | 2019-06-28 | 2023-04-03 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| US12558427B2 (en) | 2019-07-17 | 2026-02-24 | Kymera Therapeutics, Inc. | IRAK degraders and uses thereof |
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| JP7620611B2 (ja) | 2019-07-18 | 2025-01-23 | ブリストル－マイヤーズ スクイブ カンパニー | ＩＲＡＫ４阻害剤として有用なピラゾロ［３，４－ｄ］ピロロ［１，２－ｂ］ピリダジニル化合物 |
| JP7573596B2 (ja) | 2019-07-23 | 2024-10-25 | ブリストル－マイヤーズ スクイブ カンパニー | Ｉｒａｋ４阻害剤として有用なチエノピリジニルおよびチアゾロピリジニル化合物 |
| EP4010317B1 (en) | 2019-08-06 | 2024-06-19 | Bristol-Myers Squibb Company | Bicyclic heterocyclic compounds useful as irak4 inhibitors |
| CN114206874B (zh) | 2019-08-13 | 2024-08-02 | 百时美施贵宝公司 | 可用作irak4抑制剂的双环杂芳基化合物 |
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| CA3161878A1 (en) | 2019-12-17 | 2021-06-24 | Matthew M. Weiss | Irak degraders and uses thereof |
| EP4076524A4 (en) | 2019-12-17 | 2023-11-29 | Kymera Therapeutics, Inc. | IRAQ DEGRADERS AND USES THEREOF |
| WO2021158495A1 (en) | 2020-02-03 | 2021-08-12 | Bristol-Myers Squibb Company | Benzo[5,6][1,4]dioxino[2,3-b]pyridine compounds useful as irak4 inhibitors |
| EP4100408B1 (en) | 2020-02-03 | 2024-02-28 | Bristol-Myers Squibb Company | Tricyclic heteroaryl compounds useful as irak4 inhibitors |
| TW202210483A (zh) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Irak降解劑之結晶型 |
| EP4161521A4 (en) | 2020-06-03 | 2024-07-10 | Kymera Therapeutics, Inc. | DEUTERED IRAQ DEGRADERS AND USES THEREOF |
| CA3194164A1 (en) * | 2020-09-30 | 2022-04-07 | Koichiro Arai | Pyrimidine- and nitrogen-containing bicyclic compound |
| AR124547A1 (es) | 2020-12-30 | 2023-04-05 | Kymera Therapeutics Inc | Degradadores de irak y sus usos |
| WO2022174268A1 (en) | 2021-02-15 | 2022-08-18 | Kymera Therapeutics, Inc. | Irak4 degraders and uses thereof |
| CA3217792A1 (en) | 2021-05-07 | 2022-11-10 | Kymera Therapeutics, Inc | Cdk2 degraders and uses thereof |
| JP2024540080A (ja) | 2021-10-29 | 2024-10-31 | カイメラ セラピューティクス， インコーポレイテッド | Ｉｒａｋ４分解剤およびその合成 |
| EP4472967A4 (en) | 2022-01-31 | 2026-04-15 | Kymera Therapeutics Inc | Iraqi Degradation Agents and Their Uses |
| WO2026005537A1 (ko) * | 2024-06-28 | 2026-01-02 | 주식회사 대웅제약 | 신규한 화합물, 및 이를 포함하는 암 또는 자가 면역 질환의 예방 또는 치료용 약학적 조성물 |
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| CA2450769A1 (en) | 2001-06-15 | 2002-12-27 | Vertex Pharmaceuticals Incorporated | 5-(2-aminopyrimidin-4-yl) benzisoxazoles as protein kinase inhibitors |
| AUPR688101A0 (en) | 2001-08-08 | 2001-08-30 | Luminis Pty Limited | Protein domains and their ligands |
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| ES2373226T3 (es) | 2002-06-28 | 2012-02-01 | Astellas Pharma Inc. | Derivado de diaminopirimidincarboxamida. |
| EP1651636A1 (en) | 2003-07-10 | 2006-05-03 | Neurogen Corporation | Substituted heterocyclic diarylamine analogues |
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- 2013-01-11 WO PCT/US2013/021096 patent/WO2013106614A1/en not_active Ceased
- 2013-01-11 JP JP2014552312A patent/JP6096807B2/ja not_active Expired - Fee Related
- 2013-01-11 CN CN201380013640.XA patent/CN104169275B/zh not_active Expired - Fee Related
- 2013-01-11 EP EP13700829.8A patent/EP2802577B1/en not_active Not-in-force
- 2013-01-11 US US14/371,281 patent/US8987311B2/en active Active
- 2013-01-11 ES ES13700829.8T patent/ES2630705T3/es active Active
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| CN1625400A (zh) * | 2002-02-01 | 2005-06-08 | 里格尔药品股份有限公司 | 2,4－嘧啶二胺化合物及其用途 |
| WO2004065378A1 (en) * | 2003-01-17 | 2004-08-05 | Warner-Lambert Company Llc | 2-aminopyridine substituted heterocycles as inhibitors of cellular proliferation |
| WO2005013982A1 (en) * | 2003-08-06 | 2005-02-17 | Vertex Pharmaceuticals Incorporated | Aminotriazole compounds useful as inhibitors of protein kinases |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2802577B1 (en) | 2017-03-01 |
| US8987311B2 (en) | 2015-03-24 |
| EP2802577A1 (en) | 2014-11-19 |
| JP2015503621A (ja) | 2015-02-02 |
| CN104169275A (zh) | 2014-11-26 |
| JP6096807B2 (ja) | 2017-03-15 |
| WO2013106614A1 (en) | 2013-07-18 |
| US20150045347A1 (en) | 2015-02-12 |
| ES2630705T3 (es) | 2017-08-23 |
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