CN104168998B - 通过交联制备分子印迹聚合物 - Google Patents

通过交联制备分子印迹聚合物 Download PDF

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Publication number
CN104168998B
CN104168998B CN201280070878.1A CN201280070878A CN104168998B CN 104168998 B CN104168998 B CN 104168998B CN 201280070878 A CN201280070878 A CN 201280070878A CN 104168998 B CN104168998 B CN 104168998B
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CN
China
Prior art keywords
mip
soluble
reagent
mips
template
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Expired - Fee Related
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CN201280070878.1A
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English (en)
Chinese (zh)
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CN104168998A (zh
Inventor
克劳斯·格利高里斯
伊恩·艾伦·尼科尔斯
尼古拉斯·奥托·克罗赫
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Mipsalus ApS
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Mipsalus ApS
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/36—After-treatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/268—Polymers created by use of a template, e.g. molecularly imprinted polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B01J20/285—Porous sorbents based on polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/3007—Moulding, shaping or extruding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/305—Addition of material, later completely removed, e.g. as result of heat treatment, leaching or washing, e.g. for forming pores
    • B01J20/3057—Use of a templating or imprinting material ; filling pores of a substrate or matrix followed by the removal of the substrate or matrix
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/3085—Chemical treatments not covered by groups B01J20/3007 - B01J20/3078
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3852—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography using imprinted phases or molecular recognition
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/80—Aspects related to sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J2220/82—Shaped bodies, e.g. monoliths, plugs, tubes, continuous beds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F301/00—Macromolecular compounds not provided for in groups C08F10/00 - C08F299/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2300/00—Characterised by the use of unspecified polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
CN201280070878.1A 2012-02-28 2012-02-28 通过交联制备分子印迹聚合物 Expired - Fee Related CN104168998B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2012/053332 WO2013127433A1 (en) 2012-02-28 2012-02-28 Preparation of molecular imprinted polymers by cross-linking

Publications (2)

Publication Number Publication Date
CN104168998A CN104168998A (zh) 2014-11-26
CN104168998B true CN104168998B (zh) 2016-09-28

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Country Status (11)

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US (1) US9212271B2 (enExample)
EP (1) EP2819778B1 (enExample)
JP (1) JP6063962B2 (enExample)
KR (1) KR101966483B1 (enExample)
CN (1) CN104168998B (enExample)
AU (1) AU2012371229B2 (enExample)
BR (1) BR112014019358A8 (enExample)
CA (1) CA2864908C (enExample)
HK (1) HK1205712A1 (enExample)
RU (1) RU2608743C2 (enExample)
WO (1) WO2013127433A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106492770A (zh) * 2015-09-08 2017-03-15 中国科学院大连化学物理研究所 一种组氨酸标签蛋白亲和纯化材料及其应用
IL261734B2 (en) * 2016-03-15 2023-04-01 Mipsalus Aps A method for detection and means for it
CN106731002A (zh) * 2016-12-23 2017-05-31 四川理工学院 一种氨基甲酸乙酯高效固相萃取柱的制备和使用方法
US11028203B2 (en) 2017-06-29 2021-06-08 Mipsalus Aps Molecular imprinted polymers targeting phenylalanine
KR102450952B1 (ko) * 2020-08-11 2022-10-04 부산대학교 산학협력단 천공구조를 갖는 분자각인 고분자 물질층을 포함하는 고분자 물질 기반 시트와 그 제조방법 및 고분자 물질 기반 시트를 적용한 장치
RU2753850C1 (ru) * 2020-09-30 2021-08-24 Федеральное государственное бюджетное образовательное учреждение высшего образования "Саратовский национальный исследовательский государственный университет имени Н.Г. Чернышевского" Способ получения молекулярно-импринтированного полимера
CN113149073B (zh) * 2021-03-18 2023-01-13 山东大学 一种钒酸铋的制备方法
WO2025153614A1 (en) 2024-01-16 2025-07-24 Mipsalus Aps Cross-linked polymers and their use in methods of binding cations

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007095949A2 (en) * 2006-02-21 2007-08-30 Mipsalus Aps Improved preparation of molecular imprinted polymers
CN101421035A (zh) * 2006-02-21 2009-04-29 米普萨卢斯公司 改进的分子印迹聚合物的制备方法
CN101559352A (zh) * 2009-05-15 2009-10-21 华南农业大学 用于检测三聚氰胺的分子印迹聚合物及其制备方法
WO2011033021A2 (en) * 2009-09-16 2011-03-24 Mipsalus Aps Improved purification of multi-specific receptors

Family Cites Families (9)

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US4111863A (en) 1972-08-31 1978-09-05 Dynamit Nobel Aktiengesellschaft Method of preparing polymers analogous to enzymes
SE8900130L (sv) 1989-01-16 1990-07-17 Klaus Mosbach Konceptet att med hjaelp av molekylavtrycksmetoden framstaella konstgjorda antikroppar genom imprinting av t ex antigener samt att framstaella konstgjorda entzymer genom imprintning med transition state analoger
US5994110A (en) 1995-02-10 1999-11-30 Mosbach; Klaus Methods for direct synthesis of compounds having complementary structure to a desired molecular entity and use thereof
SE9903958D0 (sv) 1999-11-02 1999-11-02 Boerje Sellergren Porous materials for selective binding or transport of molecular guests
SE0001877D0 (sv) 2000-05-22 2000-05-22 Klaus Mosbach Molecular imprinting
US6638498B2 (en) 2000-06-30 2003-10-28 Semorex Inc. Molecularly imprinted polymers for the treatment and diagnosis of medical conditions
US6849701B2 (en) * 2001-03-02 2005-02-01 E. I. Du Pont De Nemours And Company Droplet polymerization method for synthesis of molecularly imprinted polymers
EP1957194A1 (en) 2005-12-07 2008-08-20 MIP Technologies AB Agglomerated mip clusters
RU2415155C1 (ru) * 2010-02-24 2011-03-27 Учреждение Российской академии наук Институт высокомолекулярных соединений РАН Способ синтеза сетчатого полимерного плазмосорбента, молекулярно импринтированного мочевой кислотой

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007095949A2 (en) * 2006-02-21 2007-08-30 Mipsalus Aps Improved preparation of molecular imprinted polymers
CN101421035A (zh) * 2006-02-21 2009-04-29 米普萨卢斯公司 改进的分子印迹聚合物的制备方法
CN101559352A (zh) * 2009-05-15 2009-10-21 华南农业大学 用于检测三聚氰胺的分子印迹聚合物及其制备方法
WO2011033021A2 (en) * 2009-09-16 2011-03-24 Mipsalus Aps Improved purification of multi-specific receptors

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Publication number Publication date
JP2015515360A (ja) 2015-05-28
RU2014138971A (ru) 2016-04-20
EP2819778B1 (en) 2023-06-07
RU2608743C2 (ru) 2017-01-23
EP2819778C0 (en) 2023-06-07
KR20140127910A (ko) 2014-11-04
JP6063962B2 (ja) 2017-01-18
CA2864908A1 (en) 2013-09-06
WO2013127433A1 (en) 2013-09-06
AU2012371229B2 (en) 2016-10-20
HK1205712A1 (en) 2015-12-24
CA2864908C (en) 2021-01-12
US9212271B2 (en) 2015-12-15
AU2012371229A1 (en) 2014-08-07
KR101966483B1 (ko) 2019-04-05
CN104168998A (zh) 2014-11-26
EP2819778A1 (en) 2015-01-07
BR112014019358A8 (pt) 2017-07-11
BR112014019358A2 (enExample) 2017-06-20
US20150031779A1 (en) 2015-01-29

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Granted publication date: 20160928