CN104127633A - Traditional Chinese medicine composition extract for treating hyperosteogeny and preparation method thereof - Google Patents
Traditional Chinese medicine composition extract for treating hyperosteogeny and preparation method thereof Download PDFInfo
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- CN104127633A CN104127633A CN201410357731.1A CN201410357731A CN104127633A CN 104127633 A CN104127633 A CN 104127633A CN 201410357731 A CN201410357731 A CN 201410357731A CN 104127633 A CN104127633 A CN 104127633A
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Abstract
The invention relates to a medicine for treating hyperosteogeny, specifically to a traditional Chinese medicine composition extract for treating hyperosteogeny and a preparation method thereof. The traditional Chinese medicine composition extract comprises, by weight, 1 to 5 parts of saffron, 3 to 10 parts of Chinese yam, 2 to 8 parts of spatholobus stem, 5 to 12 parts of canton love-pea vine and 10 to 15 parts of buck grass. The traditional Chinese medicine composition extract substantially eliminates symptoms of hyperosteogeny and softens hyperplastic bone spurs.
Description
Technical field
The present invention relates to field of Chinese herbal, particularly relate to a kind of medicine for the treatment of hyperosteogeny.
Background technology
Hyperosteogeny be exactly refer to normal bone, joint edge how long a little bone, be commonly called as bony spur, be more common in 45 years old later middle-aged and elderly people, be apt to occur in position heavy burden, that mobility is larger, as the cervical vertebra of spinal column and lumbar vertebra, the ilium joint of lower limb and knee joint etc., within 50 years old, above old people's bone regeneration incidence rate is 98%.Produce the reason of hyperosteogeny, it is generally acknowledged: at spinal column, be because degeneration of intervertebral disc becomes to suffer chronic strain, cause interpyramidal unstablely, the ligament of intervertebral is tractive repeatedly, make its facies posterior hepatis at vertebra hemorrhage, form hematoma machine calcification and form bony spur gradually; At extremities joint, be chronic injury, the joint degeneration due to repeatedly, the tractive of edge, joint ligament facies posterior hepatis, hemorrhage, machineization is ossified and become bony spur gradually.The bony spur vascular compression of hypertrophy is neural, can cause dizziness, headache, lower limb severe pain, difficulty in walking, even paralysis.Bone matrix hyperplasia has become affects one of difficult miscellaneous diseases of life in old age quality.It is main that modern medicine is still confined to operative treatment to the treatment of bone matrix hyperplasia, because surgery cost is high, curative effect is difficult to again guarantee, patient is always weak and sickly for many years, increased the danger of operation, common people are reluctant to accept, and take hormone, indometacin, are main expectant treatment alleviating pain for the moment, and drug withdrawal is sent out.Only have hyperosteogeny to produce the heavy only a few patient of pressure symptom, just select suitable operation method to treat, so often incured loss through delay the best period for the treatment of.
Summary of the invention
The present invention is directed to above-mentioned defect, a kind of Chinese medicine composition extractum for the treatment of hyperosteogeny is provided, can dissolve cutin, softening hypertrophy bony spur, instant effect, cure rate is high.
The present invention also provides the preparation method of the Chinese medicine composition extractum of this treatment hyperosteogeny.
The Chinese medicine composition extractum for the treatment of hyperosteogeny, it forms and weight portion is: 1-5 parts of Stigma Crocis, 3-10 parts of Rhizoma Dioscoreaes, 2-8 parts of Caulis Spatholobis, 5-12 parts of Herba Abris, 10-15 parts of Herba Lycopodiis.
Preferred: 1-2 parts of Stigma Crocis, 3-6 parts of Rhizoma Dioscoreaes, 5-8 parts of Caulis Spatholobis, 7-11 parts of Herba Abris, 10-15 parts of Herba Lycopodiis.
Preferably: 2 parts of Stigma Crocis, 5 parts of Rhizoma Dioscoreaes, 7 parts of Caulis Spatholobis, 10 parts of Herba Abris, 15 parts of Herba Lycopodiis.
Wherein also contain the volatile oil extracting in Herba Asari, the weight portion of Herba Asari is 2-3 part.
The volatile oil extracting in described Herba Asari is to extract with vapour method.
The preparation method of the Chinese medicine composition extractum for the treatment of hyperosteogeny is decoction and alcohol sedimentation technique.
The production stage of described decoction and alcohol sedimentation technique is: (1) prepares the water extract of Stigma Croci, Rhizoma Dioscoreae, Caulis Spatholobi, Herba Abri and Herba Lycopodii, (2) weight ratio that is concentrated into raw material and water is 1:30, (3) add the ethanol of 90%-95% to carry out precipitate with ethanol, (4) filter, filtrate is concentrated, (5) 40 ℃-50 ℃ dry, obtains dry extract.
The Chinese medicine composition extractum of described treatment hyperosteogeny can be mixed with pharmaceutically acceptable various topical agent with conventional adjuvant.
The traditional Chinese medical science thinks that hyperosteogeny is that function goes down due to worn with age, deficiency of kidney-essence especially, and deficiency of liver-blood, bone is become homeless and is supported and degeneration occurs.The present invention further shortens compensatory process by the kidney invigorating liver nourishing, relaxing muscles and tendons to promote blood circulation, anti-inflammatory analgetic exactly.Stigma Croci has blood circulation promoting and blood stasis dispelling, removing pathogenic heat from blood and toxic substance from the body, the effect of resolving stagnation for tranquilization; Rhizoma Dioscoreae kidney tonifying gas, strengthening the spleen and stomach, the benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, helps the five internal organs, bone and muscle strengthening, grows the effect that will is calmed the nerves; Caulis Spatholobi has enriches blood, invigorate blood circulation, and the effect of dredging collateral; Herba Abri nature and flavor are sweet cool, have the effect of heat clearing away detoxicating, soothing liver-QI dissipating blood stasis; Herba Lycopodii energy expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral is usually used in joint aches, joint stuffiness; All these Chinese herbal medicine are combined by a certain percentage, greatly eliminate the symptom of hyperosteogeny, have softened the bony spur of hypertrophy simultaneously.Above-mentioned Chinese medicine mostly is blood circulation promoting and blood stasis dispelling, and easily heating after the drug of topical application, so can add Herba Asari simply in prescription.Herba Asari is the medicine of delivering of commonly using, and its property and flavor of peppery and warm, enters kidney channel.Have warming the lung for resolving phlegm cough-relieving, deliver cold expelling, dispel the wind, the effect such as antiinflammatory, pain relieving.Herba Asari, containing volatile oil, has the effect of bringing down a fever.
The present invention adopts decoction and alcohol sedimentation technique to prepare dry extract, and crushed after being dried is sprayed on the volatile oil extracting in Herba Asari above above-mentioned powder.
The Chinese medicine composition extractum that the present invention treats hyperosteogeny can coordinate with conventional adjuvant makes pharmaceutically acceptable various topical agent, and as powder, Emulsion, paste, oil preparation, ointment, solution etc., the present invention be take ointment as example.
The present invention has dissolving cutin, softening hypertrophy bony spur, and activating blood circulation to dissipate blood stasis, the effect of anti-inflammatory analgetic, treatment hyperosteogeny instant effect, cure rate is high.
The specific embodiment
Below by embodiment, the invention will be described in further detail.
Embodiment 1: the Chinese medicine composition extractum for the treatment of hyperosteogeny
Feed proportioning: Stigma Croci 2g, Rhizoma Dioscoreae 3g, Caulis Spatholobi 8g, Herba Abri 7g, Herba Lycopodii 12g.
By Stigma Croci, Rhizoma Dioscoreae, Caulis Spatholobi, Herba Abri, Herba Lycopodii 5 taste medicines decoct with water twice, and each amount of water was not to have powder to be advisable, merge decocting liquid twice, filter to get filtrate 1, be condensed into the extractum that proportion is 1:30, add 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol concentrated, dry at the temperature of 40 ℃-50 ℃, make dry extract, be ground into end.
Embodiment 2: the Chinese medicine composition extractum for the treatment of hyperosteogeny
Feed proportioning: Stigma Croci 2g, Rhizoma Dioscoreae 5g, Caulis Spatholobi 7g, Herba Abri 10g, Herba Lycopodii 15g.
By Stigma Croci, Rhizoma Dioscoreae, Caulis Spatholobi, Herba Abri, Herba Lycopodii 5 taste medicines decoct with water twice, and each amount of water was not to have powder to be advisable, merge decocting liquid twice, filter to get filtrate 1, be condensed into the extractum that proportion is 1:30, add 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol concentrated, dry at the temperature of 40 ℃-50 ℃, make dry extract, be ground into end.
Embodiment 3: the Chinese medicine composition extractum for the treatment of hyperosteogeny
Feed proportioning: Stigma Croci 1g, Rhizoma Dioscoreae 6g, Caulis Spatholobi 5g, Herba Abri 11g, Herba Lycopodii 10g, Herba Asari 3g.
By Stigma Croci, Rhizoma Dioscoreae, Caulis Spatholobi, Herba Abri, Herba Lycopodii 5 taste medicines decoct with water twice, and each amount of water was not to have powder to be advisable, merge decocting liquid twice, filter to get filtrate 1, be condensed into the extractum that proportion is 1:30, add 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol concentrated, dry at the temperature of 40 ℃-50 ℃, make dry extract, be ground into end.
Herba Asari is extracted to the volatile oil in Herba Asari with steam distillation.
The volatile oil extracting is sprayed on the above-mentioned dry extract powder making.
Embodiment 4: the Chinese medicine composition extractum for the treatment of hyperosteogeny
Feed proportioning: Stigma Croci 5g, Rhizoma Dioscoreae 4g, Caulis Spatholobi 2g, Herba Abri 12g, Herba Lycopodii 13g.
By Stigma Croci, Rhizoma Dioscoreae, Caulis Spatholobi, Herba Abri, Herba Lycopodii 5 taste medicines decoct with water twice, and each amount of water was not to have powder to be advisable, merge decocting liquid twice, filter to get filtrate 1, be condensed into the extractum that proportion is 1:30, add 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol concentrated, dry at the temperature of 40 ℃-50 ℃, make dry extract, be ground into end.
Embodiment 5: the Chinese medicine composition extractum for the treatment of hyperosteogeny
Feed proportioning: Stigma Croci 3g, Rhizoma Dioscoreae 10g, Caulis Spatholobi 4g, Herba Abri 5g, Herba Lycopodii 14g, Herba Asari 2g.
By Stigma Croci, Rhizoma Dioscoreae, Caulis Spatholobi, Herba Abri, Herba Lycopodii 5 taste medicines decoct with water twice, and each amount of water was not to have powder to be advisable, merge decocting liquid twice, filter to get filtrate 1, be condensed into the extractum that proportion is 1:30, add 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol concentrated, dry at the temperature of 40 ℃-50 ℃, make dry extract, be ground into end.
Herba Asari is extracted to the volatile oil in Herba Asari with steam distillation.
The volatile oil extracting is sprayed on the above-mentioned dry extract powder making.
Embodiment 6: the Chinese medicine composition ointment for the treatment of hyperosteogeny
The extractum that above-described embodiment 3 is made, adds the vaseline of 40 parts, stirs.
Embodiment 7: the Chinese medicine composition ointment for the treatment of hyperosteogeny
The extractum that above-described embodiment 4 is made, adds the vaseline of 40 parts, stirs.
Clinical observation
1. physical data: treatment case 147 examples, male's 103 examples wherein, women's 44 examples, 55-72 years old ages, 0.6-1.0 years 117 examples of the course of disease; 1.0-3.0 years 25 examples; 3.0 years above 5 examples.
2. case selection standard
The hospital above county level film making of take is diagnosed as hyperosteogeny as standard.
3. using method: above-mentioned ointment is spread upon on the skin at hyperosteogeny position, cover with adhesive plaster or adhesive sticker, again smear once after cleaning for 24 hours.It within 30 days, is a course for the treatment of.Reach recovery from illness general two to three courses for the treatment of.
4. criterion of therapeutical effect:
Recovery from illness: hypertrophy place pain disappears, movable walking recovers freely, and film making checks normal without recurrence.
Effective: hypertrophy place pain disappears substantially, film making checks that hypertrophy place obviously dwindles, and activity freely.
Invalid: hypertrophy place pain is without improvement, and it is all invalid that film making inspection is slightly with or without improvement.
5. experimental result: hyperosteogeny patient's 147 examples, recovery from illness patient 117 examples, effective patient's 22 examples, invalid patient's 8 examples.
Experiment conclusion: by clinical, view and emulate, treatment hyperosteogeny patient 147 examples, total effective rate is 95%, has obtained good effect.
Claims (9)
1. treat the Chinese medicine composition extractum of hyperosteogeny, it forms and weight portion is: 1-5 parts of Stigma Crocis, 3-10 parts of Rhizoma Dioscoreaes, 2-8 parts of Caulis Spatholobis, 5-12 parts of Herba Abris, 10-15 parts of Herba Lycopodiis.
2. the Chinese medicine composition extractum for the treatment of hyperosteogeny according to claim 1, wherein Stigma Croci is 1-2 parts, 3-6 parts of Rhizoma Dioscoreaes, 5-8 parts of Caulis Spatholobis, 7-11 parts of Herba Abris, 10-15 parts of Herba Lycopodiis.
3. the Chinese medicine composition extractum for the treatment of hyperosteogeny according to claim 1 and 2, wherein Stigma Croci is 2 parts, 5 parts of Rhizoma Dioscoreaes, 7 parts of Caulis Spatholobis, 10 parts of Herba Abris, 15 parts of Herba Lycopodiis.
4. according to the Chinese medicine composition extractum of the treatment hyperosteogeny described in claim 1 or 2 or 3, wherein also contain the volatile oil extracting in Herba Asari, the weight portion of Herba Asari is 2-3 part.
5. the Chinese medicine composition extractum for the treatment of according to claim 4 hyperosteogeny, the volatile oil extracting in wherein said Herba Asari is to extract with steam distillation.
6. according to the preparation method for the treatment of the Chinese medicine composition extractum of hyperosteogeny described in claim 1 or 2 or 3, be decoction and alcohol sedimentation technique.
7. treat according to claim 6 the preparation method of the Chinese medicine composition extractum of hyperosteogeny, the production stage of wherein said decoction and alcohol sedimentation technique is: (1) prepares the water extract of Stigma Croci, Rhizoma Dioscoreae, Caulis Spatholobi, Herba Abri and Herba Lycopodii, (2) weight ratio that is concentrated into raw material and water is 1:30, (3) add the ethanol of 90%-95% to carry out precipitate with ethanol, (4) filter, filtrate is concentrated, and (5) 40 ℃-50 ℃ dry, obtains dry extract.
8. according to the Chinese medicine composition extractum of the arbitrary treatment hyperosteogeny described in claim 1-5, can be mixed with pharmaceutically acceptable topical agent with conventional adjuvant.
9. the Chinese medicine composition extractum for the treatment of hyperosteogeny according to claim 8, described topical agent is ointment.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1883576A (en) * | 2006-06-01 | 2006-12-27 | 刘福生 | Externally applied medicine for treating hyperosteogeny and intervertebral disc protrusion |
| WO2007139887A2 (en) * | 2006-05-22 | 2007-12-06 | Cargill, Incorporated | Methods for treating bone or joint inflammation |
| CN103316296A (en) * | 2013-06-24 | 2013-09-25 | 柳晖 | Traditional Chinese medicine composition for treating hyperostosis |
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2014
- 2014-07-24 CN CN201410357731.1A patent/CN104127633A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007139887A2 (en) * | 2006-05-22 | 2007-12-06 | Cargill, Incorporated | Methods for treating bone or joint inflammation |
| CN1883576A (en) * | 2006-06-01 | 2006-12-27 | 刘福生 | Externally applied medicine for treating hyperosteogeny and intervertebral disc protrusion |
| CN103316296A (en) * | 2013-06-24 | 2013-09-25 | 柳晖 | Traditional Chinese medicine composition for treating hyperostosis |
Non-Patent Citations (2)
| Title |
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| 杨骏等: "中药熏蒸治疗骨性关节炎38例", 《江西中医药》 * |
| 高永生等: "威灵仙散外敷治疗骨质增生疗效观察", 《中医外治杂志》 * |
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Application publication date: 20141105 |