CN104127494A - Contraception medicine preparation for females - Google Patents
Contraception medicine preparation for females Download PDFInfo
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- CN104127494A CN104127494A CN201410393994.8A CN201410393994A CN104127494A CN 104127494 A CN104127494 A CN 104127494A CN 201410393994 A CN201410393994 A CN 201410393994A CN 104127494 A CN104127494 A CN 104127494A
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Abstract
The invention discloses a contraception medicine preparation for females. The preparation is prepared from active components and pharmaceutically acceptable auxiliary materials, wherein the active components comprise the following traditional Chinese medicinal materials in parts by weight: 15-25 parts of chrysosplenium sinicum and 42-60 parts of reinwardtia trigyna. The contraception medicine preparation disclosed by the invention is applied to contraception by using pure traditional Chinese medicines, so that various side effects caused by western medicines for contraception are avoided, the requirements of contraceptives are met, and meanwhile the requirements of effectiveness, safety, low cost, convenience in use and the like are met.
Description
Technical field
The invention belongs to medical technical field, the contraceptive medicament preparation of using in particular to a kind of women.
Background technology
At present, conventional contraceptives comprise: the contraceptive of (1) hormones; (2) in cavity of uterus, place intrauterine contraceptive loop; (3) ligation operation.Although oral hormone class contraceptive is more for convenience, female incretion is exerted an influence, easily cause endocrine regulation, thereby bring many side effect, and contraceptive effect is not very good; When intracavity placement intrauterine contraceptive loop can cause menstruation, amount of bleeding is many, and easily causes infection; Although ligation operation is practised contraception completely, after sterillization, can not give birth to again.Be that above-mentioned contraceptives all can not meet effectively simultaneously, the condition such as safety, expense are cheap, easy to use.
Summary of the invention
In view of the deficiencies in the prior art, the contraceptive medicament preparation that the object of the present invention is to provide a kind of novel women to use.This medicine is prepared from as raw material using golden saxifrage and Ramulus et Folium Reinwardtiae Trigynae, and toxic and side effects is low, safe, and contraceptive effect is good, can be used for the front oral contraception of sexual intercourse.
The object of the present invention is achieved like this:
The contraceptive medicament preparation that women uses, is prepared from by acceptable adjuvant on active component and pharmaceutics, and wherein said active component is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: golden saxifrage 15-25 part, Ramulus et Folium Reinwardtiae Trigynae 42-60 part.
Preferably, the contraceptive medicament preparation that women uses as mentioned above, wherein said active component is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: golden saxifrage 18-22 part, Ramulus et Folium Reinwardtiae Trigynae 48-53 part.
Further preferably, the contraceptive medicament preparation that women uses as mentioned above, wherein said active component is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: 20 parts of golden saxifrages, 50 parts of Ramulus et Folium Reinwardtiae Trigynaes.
It should be noted that, the traditional Chinese medicinal material raw materials that Chinese medicine preparation of the present invention adopted in the preparation has following source: golden saxifrage is selected the dry herb of the golden waist Chrysosplenium sinicum Maxim. of Saxifragaceae golden saxifrage platymiscium China.Ramulus et Folium Reinwardtiae Trigynae is selected the dry browse of flax family (Linaceae) Reinwardtia trigyna platymiscium Reinwardtia trigyna Reinwardtia trigyna (Roxb.) Planch..
The contraceptive medicament preparation that women of the present invention uses is solid orally ingestible, comprises tablet, capsule, granule.According to the common process of formulation art, those skilled in the art is easy to adjuvant available on the active component of above-mentioned Chinese medicine extract composition and pharmaceutics to be prepared into conventional solid orally ingestible, as granule, tablet, capsule.Wherein, on pharmaceutics, available adjuvant comprises filler, disintegrating agent, binding agent, correctives, lubricant etc.
Such as, the contraceptive medicament preparation that women of the present invention uses can be selected and be prepared as follows technique: take golden saxifrage and Ramulus et Folium Reinwardtiae Trigynae, pulverize, add alcoholic solution, heating and refluxing extraction, filters, and decompression recycling ethanol is extremely without alcohol taste, continue concentrated rear lyophilizing, pulverize, obtain extract; Add filler, disintegrating agent and binding agent to mix rear soft material processed extract, cross 16-32 mesh sieve wet granular processed, wet granular is fully dry in 45-60 DEG C, after dry gained granule and lubricant are mixed granule, or dry gained granule and lubricant are mixed to rear tabletting or filled capsules shell, obtain tablet or capsule.Further, in order to improve offending taste in oral formulations, in pharmaceutical preparation of the present invention, can also add appropriate correctives, or on label, wrap up sugarcoating layer.
The inventor finds after by a large amount of experimental studies, gives Chinese medicine extract of the present invention to before mice copulation female Mus and intervenes, and result can make the contraceptive prevalence rate of the successful mice of copulation reach 100%, and this points out this Chinese medicine extract thing can produce good contraceptive efficacy.Based on above result of study, the present invention also provides a kind of pharmaceutical applications, that is: the traditional Chinese medicinal material raw materials compositions of golden saxifrage and Ramulus et Folium Reinwardtiae Trigynae composition is being prepared the purposes of contraceptive.
Compared with prior art, contraceptive medicament preparation of the present invention is prepared from as raw material using natural plants golden saxifrage and Ramulus et Folium Reinwardtiae Trigynae, for the contraception of pure Chinese medicine, the side effect such as the morning sickness that causes, nauseating, vomiting, sleepy, dizzy, headache, stomachache, distending pain of the breast of practise contraception with Western medicine are avoided.Meanwhile, the contraceptive prevalence rate of this medicine reaches 100%, meet to contraceptives desiredly can meet effectively simultaneously, the condition such as safety, expense are cheap, easy to use.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is done to further description, but protection scope of the present invention is not limited to these embodiment.Every do not deviate from the change of the present invention design or be equal to substitute include within protection scope of the present invention.
The preparation of embodiment 1 extract
Take golden saxifrage 200g and Ramulus et Folium Reinwardtiae Trigynae 500g, mix, pulverize, sieve with pulverizer, adding volumetric concentration is 70% alcoholic solution 8L, and heating decocts, reflux, extract, 2h, extract altogether 3 times, merging filtrate, 4 layers of filtered through gauze, decompression recycling ethanol is extremely without alcohol taste, continue concentrated rear lyophilizing, pulverize, cross 100 mesh sieves, obtain extract.
The preparation of embodiment 2 coated tablets
Extract 8g,
Lactose 60g,
Mannitol 50g,
Starch slurry is appropriate,
Cross-linking sodium carboxymethyl cellulose 10g,
Magnesium stearate 2g.
Preparation technology: take Chinese medicine extract 8g prepared by embodiment 1, and the lactose 60g of recipe quantity, mannitol 50g and cross-linking sodium carboxymethyl cellulose 10g mistake 100 mesh sieves respectively, mix, add the rear soft material processed of appropriate amount of starch slurry, cross 20 mesh sieve wet granular processed, wet granular is fully dried in 55 DEG C, obtains dry granule; Dry gained granule and magnesium stearate are mixed to 1000 of rear pressures, then sugar coating.
The contraception experimental study of embodiment 3 Chinese medicines to mice
Cloudy bolt (Vaginal plug) be some rodent at post-coitum, a kind of stock white fluidity material forming immediately, is blocked in vagina to Cervical intracavity, is to check successfully a kind of mark of the no copulation of animal.It is at the concretionary product of intravaginal by male Mus seminal vesicle and the secretions that solidifies gland.White mice generally forms in post-coitum 4-5min.Large cloudy bolt can protrude from vaginal orifice, little in vagina or cervix uteri, need to open vaginal orifice and just can look into and see.Cloudy bolt is generally gradually softening at post-coitum 1h, after 16-24h, comes off.Only there is 4-5h but also have, and more than maximum existed 48h.In reproductive process, germ cell through processes such as implantation, differentiation, finally develops into a ripe fetus in parent uterus.Give extract of the present invention to before mice copulation female Mus and intervene, result can make the contraceptive prevalence rate of the successful mice of copulation reach 100%, and this points out this Chinese medicine extract thing can produce good contraceptive efficacy.Below concrete process of the test and result:
Healthy mature Kunming mouse, body weight 25-35g,, male 30, gives normal diet and clean tap water by female 60.Female mice is divided into four groups at random, i.e. blank group, the basic, normal, high dosage group of extract (0.5,1.0,2.0g/kg), 15 every group.Extract group gives extract prepared by the embodiment of the present invention 1 in advance by basic, normal, high dosage, 0.1ml/lOg gavage, and blank group gives normal saline 0.1ml/lOg gavage, for three days on end, every day 1 time.Four groups of mices are mated to 1 week with male Mus with 2:1 ratio respectively, during mating, check vagina every morning, opens vaginal orifice with pincet, and the copulation winner who occurs cloudy bolt is taken out respectively to sub-cage rearing, after dividing cage, female mice is put to death in the dislocation of 12d cervical vertebra, observes uterus and has or not tire son.Calculate contraceptive prevalence rate (contraceptive prevalence rate=not animal pregnancy number/laboratory animal number × 100%).
Dissect each group of experiment mice, find that blank group and administration group Pregnant Mouse Uterus diameter are thick, flesh pink, glossy, the embryo of cornua uteri is beading, is evenly distributed, and fetal development is good.Administration group not Pregnant Mouse Uterus diameter is obviously little than blank group, has no fetal development.Between each group, contraceptive prevalence rate is relatively in table 1.
The comparison of the each group of table 1 mouse pregnancy situation
Claims (6)
1. the contraceptive medicament preparation that women uses, is prepared from by acceptable adjuvant on active component and pharmaceutics, it is characterized in that described active component is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: golden saxifrage 15-25 part, Ramulus et Folium Reinwardtiae Trigynae 42-60 part.
2. the contraceptive medicament preparation that women uses according to claim 1, is characterized in that described active component is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: golden saxifrage 18-22 part, Ramulus et Folium Reinwardtiae Trigynae 48-53 part.
3. the contraceptive medicament preparation that women uses according to claim 2, is characterized in that described active component is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: 20 parts of golden saxifrages, 50 parts of Ramulus et Folium Reinwardtiae Trigynaes.
4. the contraceptive medicament preparation of using according to women described in claim 1-3 any one, is characterized in that: described Chinese medicine preparation is tablet, capsule or granule.
5. the preparation method of a contraceptive medicament preparation of using according to women described in claim 1-3 any one, it is characterized in that the method comprises the steps: to take golden saxifrage and Ramulus et Folium Reinwardtiae Trigynae, pulverize, add alcoholic solution, heating and refluxing extraction, filters, decompression recycling ethanol is extremely without alcohol taste, continue concentrated rear lyophilizing, pulverize, obtain extract; Add filler, disintegrating agent and binding agent to mix rear soft material processed extract, cross 16-32 mesh sieve wet granular processed, wet granular is fully dry in 45-60 DEG C, after dry gained granule and lubricant are mixed granule, or dry gained granule and lubricant are mixed to rear tabletting or filled capsules shell, obtain tablet or capsule.
6. the traditional Chinese medicinal material raw materials compositions being made up of golden saxifrage and Ramulus et Folium Reinwardtiae Trigynae is being prepared the purposes of contraceptive.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410393994.8A CN104127494A (en) | 2014-08-12 | 2014-08-12 | Contraception medicine preparation for females |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410393994.8A CN104127494A (en) | 2014-08-12 | 2014-08-12 | Contraception medicine preparation for females |
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| Publication Number | Publication Date |
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| CN104127494A true CN104127494A (en) | 2014-11-05 |
Family
ID=51800516
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410393994.8A Withdrawn CN104127494A (en) | 2014-08-12 | 2014-08-12 | Contraception medicine preparation for females |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491217A (en) * | 2014-11-26 | 2015-04-08 | 李健 | Intestine-moistening bowel-relaxing medicinal preparation |
| CN105434501A (en) * | 2015-12-18 | 2016-03-30 | 钟柏根 | Traditional Chinese medicine extract, and applications thereof in preparing contraceptive drugs |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948744A (en) * | 2014-05-27 | 2014-07-30 | 杨献华 | Chinese medicinal composition for treating male infertility and preparation method thereof |
-
2014
- 2014-08-12 CN CN201410393994.8A patent/CN104127494A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948744A (en) * | 2014-05-27 | 2014-07-30 | 杨献华 | Chinese medicinal composition for treating male infertility and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491217A (en) * | 2014-11-26 | 2015-04-08 | 李健 | Intestine-moistening bowel-relaxing medicinal preparation |
| CN105434501A (en) * | 2015-12-18 | 2016-03-30 | 钟柏根 | Traditional Chinese medicine extract, and applications thereof in preparing contraceptive drugs |
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| CB03 | Change of inventor or designer information |
Inventor after: Yin Zhuolian Inventor before: Liu Xuejian |
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| CB03 | Change of inventor or designer information | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20141105 |
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| WW01 | Invention patent application withdrawn after publication |