CN104122188A - Film permeability determination device and detection method thereof - Google Patents
Film permeability determination device and detection method thereof Download PDFInfo
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- CN104122188A CN104122188A CN201410402846.8A CN201410402846A CN104122188A CN 104122188 A CN104122188 A CN 104122188A CN 201410402846 A CN201410402846 A CN 201410402846A CN 104122188 A CN104122188 A CN 104122188A
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Abstract
The invention discloses a film permeability determination device. The film permeability determination device comprises two magnetic stirrers which are arranged vertically and oppositely; a diffusion cell is arranged between the inner sides of the two magnetic stirrers and comprises a first diffusion half cell for supplying and an opposite second diffusion half cell for receiving; a to-be-detected film is arranged between the first diffusion half cell and the second diffusion half cell; the first diffusion half cell and the second diffusion half cell are both provided with a liquid inlet and a liquid outlet; the liquid inlets are connected with a micro pump by guide pipes, and the other end of the micro pump is connected with a constant-temperature liquid storage cell by a guide pipe; the liquid outlet of the second diffusion half cell is connected with a detector by a guide pipe. The film permeability determination device provided by the invention has the advantages of simple structure, easiness in preparation, convenience in use, and capability of stirring efficiently by adopting vertical magnetic stirring without damaging a to-be-detected film.
Description
Technical field
The present invention relates to a kind of film permeation rate determinator and detection method thereof.
Background technology
Dressing is current modal a kind of method of preparing sustained-release preparation.The test of solution film permeability can be used for instructing the selection of adjuvant in coating material and dressing solution.Drug Percutaneous Absorption speed also can be measured with film permeation rate proving installation.Conventional film permeation rate proving installation has vertical Franz diffusion cell and horizontal Valia-Chien diffusion cell.
Vertical Franz diffusion cell is as CN2415357Y, CN2479500Y, CN102854292A, CN103048248A, CN103115852A, CN103217364A, CN201063030Y, shown in CN201514365U, containing the supply chamber of the first half and the receiving chamber of the latter half, because the supply chamber of this device cannot stir, there is static diffusion layer effect and affect measurement result, the solution in diffusion cell can not be received outside liquid storage tank and cannot accurately control the concentration of solution in diffusion cell simultaneously.In addition,, because receiving chamber does not form circulation with external solution, a large amount of samplings can cause air bubble to accumulate under diffusion barrier, make medium and diffusion barrier Contact area reduce to affect the accuracy of result.
CN102297826A discloses a kind of for measuring the horizontal device of solution permeance property, and this device adopts outer tube sleeve inner tube, and inner tube needs many places to pass outer tube to stretch out just and can connect outside liquid storage, and complex structure is difficult to promote to be manufactured; In addition, the other shortcoming of this device is that magnetic agitation magneton is horizontal positioned, and plane and film to be measured of its motion are perpendicular, and mixing effect is poor, and the while stirs magneton in experimentation and is easy to beat and gets to the damage that film to be measured causes film to be measured.In addition, the inner tube of this device and stirring magneton are wherein all horizontal positioned, and the outer tube of being separated by between stirring magneton and magnetic stirring apparatus, and mixing effect is more not good.These shortcomings are present in the horizontal Valia-Chien diffusion cell of current use simultaneously.
Summary of the invention
The object of the invention is in order to overcome above deficiency, provide a kind of powerful vertical magnetic force to stir, simple in structure, preparation is easy, film permeation rate determinator and detection method thereof easy to use.
Object of the present invention is achieved through the following technical solutions: a kind of film permeation rate determinator, comprise two relatively vertically disposed magnetic stirring apparatuss, between the inner side of two magnetic stirring apparatuss, be provided with diffusion cell, diffusion cell comprises the first diffusion half pond and relative the second diffusion half pond for accepting for supplying with, film to be measured is placed between the first diffusion half pond and the second diffusion half pond, on the first diffusion half pond and the second diffusion half pond, be equipped with an inlet and a liquid outlet, in the first diffusion half pond, by conduit, be connected with two constant temperature liquid storage tanks with micropump respectively with the inlet in the second diffusion half pond, the first diffusion half pond liquid outlet is connected with constant temperature liquid storage tank by conduit, the first diffusion half pond liquid outlet is connected with detecting device by conduit, then by conduit, be connected with constant temperature liquid storage tank, on described detecting device, be connected with signal output apparatus, in the first diffusion half pond, be provided with O-ring seal with the opening surface in the second diffusion half pond, in the first diffusion half pond and the second diffusion half pond, contain rotating stirring magneton, in the middle of being clamped in film to be measured by fixed sturcture, the first diffusion half pond and the second diffusion half pond be formed by connecting as holistic diffusion cell, stirring magneton is sucked outward by spreading the outside in half pond by the magnetic force of horizontal direction and leaves film to be measured, and be parastate with film to be measured, during stirring, magneton moves formed plane perpendicular to surface level but is parallel to film to be measured, opening part in the first diffusion half pond and the second diffusion half pond is provided with blocking structure, blocking structure separates stirring magneton and film to be measured, constant temperature liquid storage tank is by liquid storage tank, constant temperature system, stirrer and thermometer form, the material lower than 0.5W/mK is prepared from by coefficient of heat conductivity for the first diffusion half pond and the second diffusion half pond and conduit, coefficient of heat conductivity is lower than 0.5W/(mK) material be: teflon, high density polyethylene, Low Density Polyethylene, polypropylene, polymethylmethacrylate, Polyvinylchloride, polycarbonate.
A detection method for film permeation rate determinator, comprises the following steps:
In the first diffusion half pond and the second diffusion half pond, insert respectively stirring magneton, on the opening surface in the first diffusion half pond and the second diffusion half pond, load onto O-ring seal; The film to be measured that diameter is greater than to O-ring seal by fixed sturcture is clamped between the first diffusion half pond and the second diffusion half pond opening, form a fixed good diffusion cell, this fixed good diffusion cell is fixed between two vertical magnetic force stirrers and forms a disperser;
Inlet as the first diffusion half pond is connected with the constant temperature liquid storage tank that constant density is housed with micropump by conduit, then the liquid outlet in the first diffusion half pond is connected with the above-mentioned constant temperature liquid storage tank that constant density is housed by conduit and forms closed circuit, inlet as the second diffusion half pond is connected with the constant temperature liquid storage tank that blank solution is housed with a micropump by conduit simultaneously, then the liquid outlet in the second diffusion half pond is connected with detecting device by conduit, then by conduit, be connected with the above-mentioned constant temperature liquid storage tank that blank solution is housed and form closed circuit, and on detecting device, be connected with signal output apparatus, when test starts, opening liquid pump fills with respectively supply chamber and receiving chamber and keeps solution circulation, open magnetic stirring apparatus, from signal output apparatus, obtain online the concentration of determinand in acceptable solution, to calculate determinand, see through the permeability of film.
The present invention compared with prior art has advantages of:
1, this device diffusion half pond and conduit adopt the material preparation that coefficient of heat conductivity is lower, in test process, spreading liquid and external constant temperature liquid storage tank exchange solution in half pond can reach temperature control object and be incubated without overcoat, also without diffusion cell being provided to insulation circulation fluid, result is simply easily promoted the use of;
2, this opening part that installs each half pond has a blocking structure to separate film to be measured and to stir magneton, avoids stirring magneton in whipping process and damages film to be measured;
While 3, using, diffusion cell is placed between two vertical magnetic force stirrers, and the stirring magneton on film to be measured both sides is subject to magnetic force to suck the outside by diffusion half pond outward on surface level, leaves film to be measured and is parastate with film to be measured; During stirring, magneton moves formed plane perpendicular to surface level but is parallel to film to be measured, therefore film to be measured both sides solution can obtain evenly and efficiently stirring, eliminate the impact of static diffusion layer, and this state of this device also can further avoid magneton in stirring to damage film to be measured;
4, this device is connected with outside flow-through detector by micropump, realizes automatic assay;
5, acceptance pool liquid and external liquid form circulation, and sampling process can not cause the generation of air bubble, and result accurately and reliably.
accompanying drawing explanation:
Fig. 1 is structural representation of the present invention;
Fig. 2 is disperser cut-open view;
Fig. 3 is diffusion cell cut-open view;
Fig. 4 is diffusion half pond side view;
Number in the figure: 1-the first diffusion half pond; 2-the second diffusion half pond; 3-liquid outlet; 4-inlet; 5-stirs magneton; 6-O-ring seal; 7-blocking structure; 8-fixed sturcture; 9-magnetic stirring apparatus; 10-film to be measured; 11-constant temperature system; 12-liquid storage tank; 13-stirrer; 14-thermometer; 15-micropump; 16-detecting device; 17-signal output apparatus.
embodiment:
In order to deepen the understanding of the present invention, below in conjunction with embodiment and accompanying drawing, the invention will be further described, and this embodiment only, for explaining the present invention, does not form limiting the scope of the present invention.
A kind of embodiment of film permeation rate determinator as Figure 1-4: comprise two relatively vertically disposed magnetic stirring apparatuss 9, between the inner side of two magnetic stirring apparatuss 9, be provided with diffusion cell, diffusion cell (Fig. 3) comprises the first diffusion half pond 1 and relative the second diffusion half pond 2 for accepting for supplying with, film 10 to be measured is placed between the first diffusion half pond 1 and the second diffusion half pond 2, on the first diffusion half pond 1 and the second diffusion half pond 2, be equipped with an inlet 4 and a liquid outlet 3, the first diffusion half pond 1 is connected with two constant temperature liquid storage tanks with micropump 15 by conduit respectively with the second diffusion half pond 2 inlets 4, the first diffusion half pond 1 liquid outlet 3 is connected with constant temperature liquid storage tank by conduit, the first diffusion half pond 1 liquid outlet 3 is connected with detecting device 16 by conduit, then by conduit, be connected with constant temperature liquid storage tank, on detecting device 16, be connected with signal output apparatus 17.Opening surface in the first diffusion half pond 1 and the second diffusion half pond 2 is provided with O-ring seal 6, in the first diffusion half pond 1 and the second diffusion half pond 2, contain rotating stirring magneton 5, in the middle of being clamped in film 10 to be measured by fixed sturcture 8, the first diffusion half pond 1 and the second diffusion half pond 2 be formed by connecting as holistic diffusion cell, stirring magneton 5 is sucked outward by spreading the outside in half pond by the magnetic force of horizontal direction and leaves film 10 to be measured, and be parastate with film to be measured, during stirring, magneton moves formed plane perpendicular to surface level but is parallel to film to be measured, opening part in the first diffusion half pond 1 and the second diffusion half pond 2 is provided with blocking structure 7, blocking structure 7 separates stirring magneton 5 and film to be measured 10, constant temperature liquid storage tank is by liquid storage tank 12, constant temperature system 11, stirrer 13 and thermometer 14 form, the material lower than 0.5W/mK is prepared from by coefficient of heat conductivity for the first diffusion half pond 1 and the second diffusion half pond 2 and conduit, coefficient of heat conductivity is lower than 0.5W/(mK) material be: teflon, high density polyethylene, Low Density Polyethylene, polypropylene, polymethylmethacrylate, Polyvinylchloride, polycarbonate.
A detection method for film permeation rate determinator, comprises the following steps:
At the first diffusion half pond 1 and the second interior stirring magneton of inserting respectively in diffusion half pond 2, on the opening surface in the first diffusion half pond 1 and the second diffusion half pond 2, load onto O-ring seal; The film to be measured that diameter is greater than to O-ring seal by fixed sturcture is clamped between the first diffusion half pond 1 and the second diffusion half pond 2 openings, form a fixed good diffusion cell (Fig. 3), this fixed good diffusion cell is fixed on and between two vertical magnetic force stirrers, forms a disperser (Fig. 2);
Inlet as the first diffusion half pond is connected with the constant temperature liquid storage tank that constant density is housed with a micropump by conduit, then the liquid outlet in the first diffusion half pond is connected with the above-mentioned constant temperature liquid storage tank that constant density is housed by conduit and forms closed circuit, inlet as the second diffusion half pond is connected with the constant temperature liquid storage tank that blank solution is housed with a micropump by conduit simultaneously, then the liquid outlet in the second diffusion half pond is connected with detecting device by conduit, then by conduit, be connected with the above-mentioned constant temperature liquid storage tank that blank solution is housed and form closed circuit, and on detecting device, be connected with signal output apparatus, when test starts, opening liquid pump fills with respectively supply chamber and receiving chamber and keeps solution circulation, open magnetic stirring apparatus, from signal output apparatus, obtain online the concentration of determinand in acceptable solution, to calculate determinand, see through the permeability of film.
The present invention adopts the material preparation that coefficient of heat conductivity is lower, in test process, spreading liquid and external constant temperature liquid storage tank exchange solution in half pond can reach temperature control object and be incubated without overcoat, also without device being provided to insulation circulation fluid, result is simply easily promoted the use of; This opening part that installs each half pond has a blocking structure to separate film to be measured and to stir magneton; During use, diffusion cell is placed between two vertical magnetic force stirrers, the stirring magneton on film to be measured both sides is subject to magnetic force to suck the outside by diffusion half pond outward on surface level, leave film to be measured and be parastate with film to be measured, so this device is inhaled double action outward to avoid magneton in stirring to damage film to be measured by blocking structure and stirring magneton; During stirring, magneton moves formed plane perpendicular to surface level but is parallel to film to be measured, and film to be measured both sides solution can obtain evenly and efficiently stirring, and can eliminate the impact of static diffusion layer simultaneously; This device is connected with outside flow-through detector by micropump, realizes automatic assay; Acceptance pool liquid and external liquid form circulation, and sampling process can not cause the generation of air bubble, and result accurately and reliably.
Claims (8)
1. a film permeation rate determinator, it is characterized in that: comprise two relatively vertically disposed magnetic stirring apparatuss (9), between the inner side of two described magnetic stirring apparatuss (9), be provided with diffusion cell, described diffusion cell comprises the first diffusion half pond (1) and relative the second diffusion half pond (2) for accepting for supplying with, film to be measured (10) is placed between the first diffusion half pond (1) and the second diffusion half pond (2), on described the first diffusion half pond (1) and the second diffusion half pond (2), be equipped with an inlet (4) and a liquid outlet (3), in described the first diffusion half pond (1), by conduit, be connected with two constant temperature liquid storage tanks with micropump (15) respectively with the second diffusion half pond (2) inlet (4), described the first diffusion half pond (1) liquid outlet (3) is connected with constant temperature liquid storage tank by conduit, the first diffusion half pond (1) liquid outlet (3) is connected with detecting device (16) by conduit, then by conduit, be connected with constant temperature liquid storage tank, on described detecting device (16), be connected with signal output apparatus (17).
2. a kind of film permeation rate determinator according to claim 1, is characterized in that: in described the first diffusion half pond (1) and the second opening surface that spreads half pond (2), be provided with O-ring seal (6).
3. according to a kind of film permeation rate determinator described in claim 1 and 2, it is characterized in that: in described the first diffusion half pond (1) and the second diffusion half pond (2) neutralization, have rotating stirring magneton (5), described the first diffusion half pond (1) and the second diffusion half pond (2) are formed by connecting as holistic diffusion cell in the middle of film to be measured (10) being clamped in by fixed sturcture (8).
4. a kind of film permeation rate determinator according to claim 3, it is characterized in that: the opening part in described the first diffusion half pond (1) and the second diffusion half pond (2) is provided with blocking structure (7), and described blocking structure (7) separates stirring magneton (5) and film to be measured (10).
5. device according to claim 1, it is characterized in that: stirring magneton (5) is sucked outward by spreading the outside in half pond by the magnetic force of horizontal direction and leaves film to be measured (10), and be parastate with film to be measured, during stirring, magneton moves formed plane perpendicular to surface level but is parallel to film to be measured.
6. a kind of film permeation rate determinator according to claim 1, is characterized in that: described constant temperature liquid storage tank is comprised of liquid storage tank (12), constant temperature system (11), stirrer (13) and thermometer (14).
7. a kind of film permeation rate determinator according to claim 1, it is characterized in that: described the first diffusion half pond (1) and second spread half pond (2) and conduit by coefficient of heat conductivity lower than 0.5W/(mK) material be prepared from, described coefficient of heat conductivity is lower than 0.5W/(mK) material be: teflon, high density polyethylene, Low Density Polyethylene, polypropylene, polymethylmethacrylate, Polyvinylchloride, polycarbonate.
8. a detection method for film permeation rate determinator, is characterized in that: comprise the following steps:
1) in the first diffusion half pond (1) and the second diffusion half pond (2), insert respectively stirring magneton, on the opening surface in the first diffusion half pond (1) and the second diffusion half pond (2), load onto O-ring seal;
2) film to be measured that by fixed sturcture, diameter is greater than to O-ring seal is clamped between the first diffusion half pond (1) and the second diffusion half pond (2) opening, form a fixed good diffusion cell, this fixed good diffusion cell is fixed between two vertical magnetic force stirrers and forms a disperser;
3) inlet in the first diffusion half pond (1) is connected with the constant temperature liquid storage tank that constant density is housed with a micropump by conduit, then the liquid outlet in the first diffusion half pond (1) is connected with the above-mentioned constant temperature liquid storage tank that constant density is housed by conduit and forms closed circuit, the inlet in the second diffusion half pond (2) is connected with the constant temperature liquid storage tank that blank solution is housed with a micropump by conduit simultaneously, then the liquid outlet in the second diffusion half pond (2) is connected with detecting device by conduit, then by conduit, be connected with the above-mentioned constant temperature liquid storage tank that blank solution is housed and form closed circuit, and on detecting device, be connected with signal output apparatus, when test starts, opening liquid pump fills with respectively supply chamber and receiving chamber and keeps solution circulation, open magnetic stirring apparatus, from signal output apparatus, obtain online the concentration of determinand in acceptable solution, to calculate determinand, see through the permeability of film.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105092409A (en) * | 2015-08-24 | 2015-11-25 | 江苏苏博特新材料股份有限公司 | Test device and detection method for testing cement and emulsified asphalt adsorption rates |
| CN113433036A (en) * | 2021-08-04 | 2021-09-24 | 苏州大学 | Device and method for measuring diffusion coefficient of solute in fluid medium |
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Patent Citations (6)
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| US5694196A (en) * | 1994-03-22 | 1997-12-02 | Kakuji Tojo | Experimental instrument for examining permeability of a flowing cornea and an experimental unit using said experimental instrument |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105092409A (en) * | 2015-08-24 | 2015-11-25 | 江苏苏博特新材料股份有限公司 | Test device and detection method for testing cement and emulsified asphalt adsorption rates |
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| CN113433036A (en) * | 2021-08-04 | 2021-09-24 | 苏州大学 | Device and method for measuring diffusion coefficient of solute in fluid medium |
| CN113433036B (en) * | 2021-08-04 | 2023-02-10 | 苏州大学 | Device and method for measuring diffusion coefficient of solute in fluid medium |
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| CN104122188B (en) | 2016-10-05 |
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Address after: 226000 No. 1, Guangxing Road, export processing zone, Nantong Economic and Technological Development Zone, Jiangsu Province Patentee after: Nantong Lianya Pharmaceutical Co.,Ltd. Address before: 226000 No. 1, Guangxing Road, export processing zone, Nantong Economic and Technological Development Zone, Jiangsu Province Patentee before: NOVAST LABORATORIES (CHINA) Ltd. |
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