CN104116741A - Vilazodone hydrochloride composition and preparation method thereof - Google Patents
Vilazodone hydrochloride composition and preparation method thereof Download PDFInfo
- Publication number
- CN104116741A CN104116741A CN201310146602.3A CN201310146602A CN104116741A CN 104116741 A CN104116741 A CN 104116741A CN 201310146602 A CN201310146602 A CN 201310146602A CN 104116741 A CN104116741 A CN 104116741A
- Authority
- CN
- China
- Prior art keywords
- vilazodone hydrochloride
- microcarrier
- preparation
- surfactant
- vilazodone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
The invention relates to a vilazodone hydrochloride composition and a preparation method thereof. The composition includes vilazodone hydrochloride, a microcarrier and pharmaceutically acceptable excipients for an oral solid preparation. The preparation method is as below: mixing and crushing vilazodone hydrochloride and the microcarrier, and evenly mixing the mixture with pharmaceutically acceptable excipients for oral solid preparation. The obtained composition preparation has greatly improved dissolution in vitro, and in vivo bioavailability reaching bioequivalence to VIIBRYD.
Description
Technical field
The present invention relates to pharmaceutical composition containing Vilazodone Hydrochloride and preparation method thereof, belong to medical technical field.
Background technology
Along with social development, the pressure of the aspect such as spirit, psychology that fast pace brings, the sickness rate of depression obviously increases.Depression comprises the polytypes such as single phase property depression (being major depressive disorder and dysthymia), adjustment disorder, slight depression, season affective disorders, manic depression; wherein major depressive disorder claims again major depression obstacle, and its symptom comprises: depressed, interest reduction, body weight or the appetite of daily routines are obviously declined, insomnia or hypersomnia, be on tenterhooks/pace that (psychomotor agitation), feeling of fatigue or hypersomnia, sense of guilt or oneself belittle, suicidal thought.After morbidity, can affect patient's work, sleep, study, diet and recreation.
Vilazodone Hydrochloride (vilazodone hydrochloride) has the structure as formula I, chemistry is by name: 5-［ 4-［ 4-(5-cyano-1 H-indol--3-yl) butyl ］-1-piperazinyl ］-2-benzofuran oxamides hydrochlorate, for first indolyl amine antidepressants, belong to selective serotonin reuptake inhibitor and 5-HT
1Aacceptor portion agonist.
Existing document is more extensive for the research of Vilazodone Hydrochloride crystal formation, wherein notification number is in the patent documentation of CN100384841C, CN101139345B, all to have given openly for the multiple crystal habit form of Vilazodone Hydrochloride, comprises Vilazodone Hydrochloride solvate crystal formation, Vilazodone Hydrochloride hydrate crystal forms and Vilazodone Hydrochloride dehydration crystal formation, vilazodone dihydrochloride crystal formation, amorphous hydrochloric acid vilazodone.The present invention's following " crystal formation " classification is the class definition according to each crystal formation in CN100384841C document.
FDA (Food and Drug Adminstration) is in approval on January 21st, 2011 Vilazodone Hydrochloride tablet (trade name
) being used for the treatment of adult's major depressive disorder, prior art shows that Vilazodone Hydrochloride crystalline form IV has the character such as stripping relatively preferably,
what adopt that is to say Vilazodone Hydrochloride crystalline form IV.The dissolution properties difference of Vilazodone Hydrochloride different crystal forms is larger, the stripping of the Vilazodone Hydrochloride crystal formation except above-mentioned crystalline form IV is poor, be difficult to be used as preparation medicine, conventional preparation technique means are difficult to the preparation In Vitro Dissolution of each crystal formation to reach unanimously, and these means comprise: reduce particle diameter, pH adjusting agent, solubilizing agent, solid dispersion etc.
In view of the stripping problem of Vilazodone Hydrochloride crystal formation except above-mentioned crystalline form IV, and Vilazodone Hydrochloride great value pharmaceutically, be very necessary for Vilazodone Hydrochloride crystal formation compositions and preparation method research.The present invention, just by the application of several formulations means, has solved the problems referred to above, makes the solid preparation of Vilazodone Hydrochloride different crystal forms, reached with
stripping consistent, and in animal body with
bioequivalent effect.
Summary of the invention
The definition of Vilazodone Hydrochloride different crystal forms of the present invention is consistent with the definition of Vilazodone Hydrochloride different crystal forms in patent CN100384841C.
One of object of the present invention is to provide a kind of Vilazodone Hydrochloride compositions, to solve the low problem of bioavailability in other each crystal formation poor solubility beyond demineralizing acid vilazodone crystalline form IV, body, improves bioavailability in dissolution in vitro and body.
Vilazodone Hydrochloride compositions of the present invention is achieved through the following technical solutions:
Said composition comprises Vilazodone Hydrochloride, is total to microcarrier and the pharmaceutically acceptable adjuvant of oral solid formulation.Wherein said microcarrier altogether refers in the present composition and mixes in advance common micronized carrier with Vilazodone Hydrochloride, the effect that it plays Vilazodone Hydrochloride stripping in promotion compositions, improves bioavailability.
Further, Vilazodone Hydrochloride is Vilazodone Hydrochloride crystal formation, comprises the Vilazodone Hydrochloride crystal formation except crystalline form IV.
Further again, the weight ratio of microcarrier and Vilazodone Hydrochloride is 0.1～7:1 altogether, and preferred weight ratio is 0.5～5:1.
Further again, altogether microcarrier is wherein one or more of cyclodextrin, cyclodextrin derivative, lactose, mannitol, microcrystalline Cellulose, polyvinylpolypyrrolidone.Described cyclodextrin derivative is selected from betacyclodextrin, HYDROXYPROPYL BETA-CYCLODEXTRIN.
Further again, the pharmaceutically acceptable adjuvant of oral solid formulation comprises filler, disintegrating agent, lubricant, fluidizer.Wherein filler is selected from one or more in lactose, mannitol, microcrystalline Cellulose, starch, cellulose-lactose, mannitol-starch, starch-lactose; Disintegrating agent is selected from one or more in dried starch, low-substituted hydroxypropyl cellulose, carboxymethyl starch sodium, polyvinylpolypyrrolidone, cross-linking sodium carboxymethyl cellulose; Fluidizer is selected from one or both of silicon dioxide, colloidal silica; Lubricant is selected from one or more in magnesium stearate, Pulvis Talci, polyethylene glycol 6000.
Further again, in compositions, each amounts of components accounts for the ratio of composition total weight and is: Vilazodone Hydrochloride: 5%～12%, and microcarrier altogether: 1%～80%, filler: 10%～80%, disintegrating agent: 0.1%～5%; Lubricant: 0.1%～3%, fluidizer: 0.1%～3%.The ratio that preferred each amounts of components accounts for composition total weight is: Vilazodone Hydrochloride 8%～10%, altogether microcarrier: 5%～70%, and filler: 10%～60%, disintegrating agent: 0.5%～4%, lubricant: 0.5%～2.5%, fluidizer: 0.5%～2.5%.
Further again, described compositions can also add surfactant, and described surfactant comprises ionic surfactant and nonionic surfactant.
Further again, surfactant is selected from one or more of sodium lauryl sulphate, phospholipid, poloxamer class, GREMAPHOR GS32 class, ethoxylation polysorbate esters, poly-hydroxy stearic acid ethyl ester apoplexy due to endogenous wind, one or more in preferably sodium dodecyl sulfate, phospholipid, Pluronic/Lutrol F 44, PLURONICS F87, poloxamer 237, Pluronic/Lutrol F 108, poloxamer188, polyoxyethylene sorbitan monoleate, polysorbate 60, polysorbate 40, polysorbate 20, Cremophor EL, Cremophor RH40, Cremophor RH60.
Further again, the ratio that the consumption of surfactant accounts for composition total weight is: 0.05%～10%, and preferred consumption is 0.5%～8%.
The preparation method that another object of the present invention is to provide above-mentioned Vilazodone Hydrochloride compositions, feature is as follows: Vilazodone Hydrochloride is pulverized after microcarrier mixing together, mixing homogeneously with the pharmaceutically acceptable adjuvant of oral solid formulation, made tablet or capsule.
Further again, Vilazodone Hydrochloride together microcarrier mixes, and being crushed to particle diameter is 1～20 μ m.
Further again, can also together after microcarrier co-grinding, add alcoholic solution or the aqueous solution of surfactant at Vilazodone Hydrochloride, mix homogeneously with the pharmaceutically acceptable medium of oral solid formulation again through disperseing, after dry, make tablet or capsule.
In addition, Vilazodone Hydrochloride together the grinding mode of the mixture of microcarrier comprise grind, comminution by gas stream etc., can adopt the equipment such as ball mill, jet mill, colloid mill to carry out.The technique of making tablet or capsule comprises wet granulation, dry granulation, direct compression, the direct filled capsules of powder, particles filled capsule etc.
Advantage of the present invention is, has overcome prior art defect, has solved in prior art the In Vitro Dissolution problem of other Vilazodone Hydrochloride crystal formation preparations except crystalline form IV, and has improved bioavailability in composition.In addition, in the present composition, also can add surfactant, can solve better stripping problem.
Brief description of the drawings
Fig. 1 embodiment 1-8 prepare sample with
stripping curve contrast (0.1mol/L hydrochloric acid solution is medium).Fig. 2 embodiment 1-8 prepare sample with
stripping curve contrast (acetum that volume fraction is 0.1% is medium).
Fig. 3 embodiment 1-8 prepare sample with
stripping curve contrast (water is medium).
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated, but do not limit the present invention.
The present invention's Vilazodone Hydrochloride used refers to Vilazodone Hydrochloride crystal formation.
The patent documentation (24th～29 pages of description) that following Vilazodone Hydrochloride different crystal forms used is CN100384841C according to notification number is prepared gained, and other agents useful for same are commercially available obtaining.
Embodiment 1
The preparation of table 1 Vilazodone Hydrochloride tablets/capsules
Preparation process: Vilazodone Hydrochloride powder particle diameter to 5 μ m, to mix homogeneously with other adjuvants in prescription, direct compression makes tablet or the direct fill of powder becomes capsule.
Embodiment 2
The preparation of table 2 Vilazodone Hydrochloride tablets/capsules
Preparation process: Vilazodone Hydrochloride powder particle diameter to 5 μ m, mix homogeneously with other adjuvants except silicon dioxide, magnesium stearate in prescription, add the aqueous solution of polyoxyethylene sorbitan monoleate to granulate, after dry, granulate, add silicon dioxide, magnesium stearate to mix, tabletting is made tablet.
Embodiment 3
The preparation of table 3 Vilazodone Hydrochloride tablets/capsules
Preparation process: powder particle diameter to 20 μ m after Vilazodone Hydrochloride mixes with lactose, betacyclodextrin, to mix homogeneously with other adjuvants in prescription, direct compression makes tablet or the direct fill of powder becomes capsule.
Embodiment 4
The preparation of table 4 Vilazodone Hydrochloride tablets/capsules
Preparation process: Vilazodone Hydrochloride is crushed to particle diameter 15 μ m after mixing with mannitol, adds the alcoholic solution of phospholipid, after disperseing, being dried, mixs homogeneously with other adjuvants in prescription, and after wet granule compression tablet is made tablet or wet granulation, fill becomes capsule.
Embodiment 5
The preparation of table 5 Vilazodone Hydrochloride tablets/capsules
Preparation process: Vilazodone Hydrochloride is crushed to particle diameter 10 μ m after mixing with polyvinylpolypyrrolidone, adds the aqueous solution of poloxamer188, after disperseing, being dried, mixs homogeneously with other adjuvants in prescription, and direct compression makes tablet or the direct fill of powder becomes capsule.
Embodiment 6
The preparation of table 6 Vilazodone Hydrochloride tablets/capsules
Preparation process: Vilazodone Hydrochloride is crushed to particle diameter 8 μ m after mixing with mannitol, mixs homogeneously with other adjuvants in prescription, and wet granulation is made tablet or Sprinkle Caps.
Embodiment 7
The preparation of table 7 Vilazodone Hydrochloride tablets/capsules
Preparation process: Vilazodone Hydrochloride is crushed to particle diameter after mixing with HYDROXYPROPYL BETA-CYCLODEXTRIN be 5 μ m, add the aqueous solution of polyoxyethylene sorbitan monoleate, after disperseing, being dried, mix homogeneously with other adjuvants in prescription, direct compression makes tablet or the direct fill of powder becomes capsule.
Embodiment 8
The preparation of table 8 Vilazodone Hydrochloride tablets/capsules
Preparation process: Vilazodone Hydrochloride is crushed to particle diameter 2 μ m after mixing with microcrystalline Cellulose, adds the alcoholic solution of Cremophor RH40, after disperseing, being dried, mixs homogeneously with other adjuvants in prescription, and wet granulation is made tablet or capsule.
Embodiment 9 dissolutions are investigated
Press 2010 editions annex of Chinese Pharmacopoeia (annex X C), adopt oar method, 60 revs/min of rotating speeds, 37 ± 0.5 DEG C of temperature, respectively taking 0.1mol/L hydrochloric acid solution, 0.1%(volume fraction) acetum and water is as medium, determined by ultraviolet spectrophotometry dissolution, result shows: sample 1 and 2 is in 0.1%(volume fraction) in acetic aid medium stripping still can, but stripping is lower in 0.1mol/L hydrochloric acid and water, sample 3～8 with
in Vitro Dissolution in different medium, all reach unanimously (accompanying drawing 1,2,3).
Embodiment 10 pharmacokinetics tests
Self-control tablet with
pharmacokinetics comparison is carried out in agent, adopts once dog PK test under feed state.Get 8 Beagle dogs, male and female half and half.Experiment adopts two stage binary cycles to intersect, by own control contrived experiment scheme.
Pharmacokinetic parameter after table 9Beagle dog oral administration vilazodone tablet (40mg/ sheet)
Result shows, sample 1 and 2 and
biological inequivalence, T
maxthere is significant difference (P>0.05) through non parametric method inspection; Sample 3～8 with
bioequivalence, T
maxthere is no significant difference (P>0.05) through non parametric method inspection.
Claims (10)
1. a Vilazodone Hydrochloride compositions, is characterized in that: said composition comprises Vilazodone Hydrochloride, is total to microcarrier and the pharmaceutically acceptable adjuvant of oral solid formulation.
2. compositions according to claim 1, is characterized in that: microcarrier is selected from one or more in lactose, mannitol, microcrystalline Cellulose, polyvinylpolypyrrolidone, cyclodextrin and derivant thereof altogether.
3. compositions according to claim 1, is characterized in that: the weight ratio of microcarrier and Vilazodone Hydrochloride is altogether: 0.1～7:1, preferably 0.5-5:1.
4. compositions according to claim 1, is characterized in that: the pharmaceutically acceptable adjuvant of described oral solid formulation comprises filler, disintegrating agent, lubricant, fluidizer; The ratio that each amounts of components accounts for composition total weight is: Vilazodone Hydrochloride 5%～12%, microcarrier 1%～80% altogether, filler 10%～80%, disintegrating agent 0.1%～5%, lubricant 0.1%～3%, fluidizer 0.1%～3%; The ratio that preferred each amounts of components accounts for composition total weight is: Vilazodone Hydrochloride 8%～10%, altogether microcarrier: 5%～70%, and filler: 10%～60%, disintegrating agent: 0.5%～4%, lubricant: 0.5%～2.5%, fluidizer: 0.5%～2.5%.
5. compositions according to claim 4, it is characterized in that: described filler is selected from lactose, mannitol, microcrystalline Cellulose, starch, cellulose-lactose, mannitol-starch, one or more in starch-lactose, described disintegrating agent is selected from dried starch, low-substituted hydroxypropyl cellulose, carboxymethyl starch sodium, polyvinylpolypyrrolidone, one or more in cross-linking sodium carboxymethyl cellulose, described fluidizer is selected from silicon dioxide, one or both in colloidal silica, described lubricant is selected from magnesium stearate, Pulvis Talci, one or more in polyethylene glycol 6000.
6. according to the compositions described in any one in claim 1 to 5, it is characterized in that: the ratio that also can add surfactant, the consumption of described surfactant to account for composition total weight is: 0.05%～10%, preferably 0.5%～8%.
7. compositions according to claim 6, it is characterized in that: surfactant comprises ionic surfactant and nonionic surfactant one or more of preferred phospholipid, sodium lauryl sulphate, poloxamer class, GREMAPHOR GS32 class, ethoxylation polysorbate esters and poly-hydroxy stearic acid ethyl ester apoplexy due to endogenous wind.
8. a method of preparing compositions claimed in claim 1, is characterized in that, Vilazodone Hydrochloride is pulverized after microcarrier mixing together, then mixed homogeneously with the pharmaceutically acceptable adjuvant of oral solid formulation.
9. preparation method according to claim 8, is characterized in that: Vilazodone Hydrochloride together microcarrier to be crushed to particle diameter be 1～20 μ m after mixing.
10. preparation method according to claim 9, it is characterized in that: can also be at Vilazodone Hydrochloride together after microcarrier co-grinding, add alcoholic solution or the aqueous solution of surfactant, after disperseing, being dried, mix homogeneously with the pharmaceutically acceptable medium of oral solid formulation again.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310146602.3A CN104116741B (en) | 2013-04-24 | 2013-04-24 | Vilazodone Hydrochloride composition and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310146602.3A CN104116741B (en) | 2013-04-24 | 2013-04-24 | Vilazodone Hydrochloride composition and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104116741A true CN104116741A (en) | 2014-10-29 |
| CN104116741B CN104116741B (en) | 2019-06-11 |
Family
ID=51762522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310146602.3A Active CN104116741B (en) | 2013-04-24 | 2013-04-24 | Vilazodone Hydrochloride composition and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104116741B (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105125512A (en) * | 2015-09-09 | 2015-12-09 | 山东大学 | Crystal V-type puerarin tablets and preparation method thereof |
| CN106667939A (en) * | 2017-02-14 | 2017-05-17 | 万全万特制药（厦门）有限公司 | Orally disintegrating tablet containing vilazodone hydrochloride and preparation method thereof |
| WO2018082557A1 (en) * | 2016-11-02 | 2018-05-11 | Sunshine Lake Pharma Co., Ltd. | Vilazodone inclusion complexes, compositions and preparation thereof |
| WO2020119698A1 (en) * | 2018-12-13 | 2020-06-18 | 广东东阳光药业有限公司 | Vilazodone solid dispersion and preparation method therefor |
| CN111346097A (en) * | 2018-12-22 | 2020-06-30 | 江苏先声药业有限公司 | Composition and preparation method thereof |
| CN114652671A (en) * | 2020-12-23 | 2022-06-24 | 上海博志研新药物技术有限公司 | Vilazodone pharmaceutical composition, preparation method and application thereof |
| WO2023098745A1 (en) * | 2021-11-30 | 2023-06-08 | 广东东阳光药业有限公司 | Vilazodone composition, pharmaceutical preparation thereof, preparation therefor, and use thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102249979A (en) * | 2011-07-12 | 2011-11-23 | 上海开义医药化工有限公司 | Method for preparing 3-(4-chlorobutyryl)-1H-indole-5-methylcyanogen |
| CN102267985A (en) * | 2011-06-15 | 2011-12-07 | 上海医药工业研究院 | Preparation method for vilazodone and hydrochloride thereof |
| CN102949364A (en) * | 2011-08-30 | 2013-03-06 | 天津药物研究院 | Sustained release tablet containing effective component hydrochloric acid vilazodone |
-
2013
- 2013-04-24 CN CN201310146602.3A patent/CN104116741B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102267985A (en) * | 2011-06-15 | 2011-12-07 | 上海医药工业研究院 | Preparation method for vilazodone and hydrochloride thereof |
| CN102249979A (en) * | 2011-07-12 | 2011-11-23 | 上海开义医药化工有限公司 | Method for preparing 3-(4-chlorobutyryl)-1H-indole-5-methylcyanogen |
| CN102949364A (en) * | 2011-08-30 | 2013-03-06 | 天津药物研究院 | Sustained release tablet containing effective component hydrochloric acid vilazodone |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105125512B (en) * | 2015-09-09 | 2018-04-17 | 山东大学 | A kind of crystalline substance V-type Puerarin tablet and preparation method thereof |
| CN105125512A (en) * | 2015-09-09 | 2015-12-09 | 山东大学 | Crystal V-type puerarin tablets and preparation method thereof |
| US10688090B2 (en) | 2016-11-02 | 2020-06-23 | Sunshine Lake Pharma Co., Ltd. | Vilazodone inclusion complexes, compositions and preparation thereof |
| WO2018082557A1 (en) * | 2016-11-02 | 2018-05-11 | Sunshine Lake Pharma Co., Ltd. | Vilazodone inclusion complexes, compositions and preparation thereof |
| CN109922807A (en) * | 2016-11-02 | 2019-06-21 | 广东东阳光药业有限公司 | Vilazodone inclusion compound and combinations thereof and preparation method |
| US11517569B2 (en) | 2016-11-02 | 2022-12-06 | Sunshine Lake Pharma Co., Ltd. | Vilazodone inclusion complexes, compositions and preparation thereof |
| CN106667939A (en) * | 2017-02-14 | 2017-05-17 | 万全万特制药（厦门）有限公司 | Orally disintegrating tablet containing vilazodone hydrochloride and preparation method thereof |
| WO2020119698A1 (en) * | 2018-12-13 | 2020-06-18 | 广东东阳光药业有限公司 | Vilazodone solid dispersion and preparation method therefor |
| CN113164473A (en) * | 2018-12-13 | 2021-07-23 | 广东东阳光药业有限公司 | Vilazodone solid dispersion and preparation method thereof |
| CN113164394A (en) * | 2018-12-13 | 2021-07-23 | 广东东阳光药业有限公司 | Vilazodone solid dispersion and preparation method thereof |
| CN113164394B (en) * | 2018-12-13 | 2023-06-23 | 广东东阳光药业有限公司 | Vilazodone solid dispersion and preparation method thereof |
| CN111346097A (en) * | 2018-12-22 | 2020-06-30 | 江苏先声药业有限公司 | Composition and preparation method thereof |
| CN114652671A (en) * | 2020-12-23 | 2022-06-24 | 上海博志研新药物技术有限公司 | Vilazodone pharmaceutical composition, preparation method and application thereof |
| WO2022135343A1 (en) * | 2020-12-23 | 2022-06-30 | 上海博志研新药物技术有限公司 | Vilazodone pharmaceutical composition, preparation method therefor and use thereof |
| WO2023098745A1 (en) * | 2021-11-30 | 2023-06-08 | 广东东阳光药业有限公司 | Vilazodone composition, pharmaceutical preparation thereof, preparation therefor, and use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104116741B (en) | 2019-06-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104116741A (en) | Vilazodone hydrochloride composition and preparation method thereof | |
| US7514552B2 (en) | Cellulose powder | |
| CN105246598B (en) | Abiraterone acetate ester formulation | |
| JP6086798B2 (en) | Tablet manufacturing method | |
| CN101129346B (en) | Ambroxol hydrochloride oral cavity disintegrating tablet and method of producing the same | |
| TWI572360B (en) | Tiny cellulose powder | |
| CN106687112A (en) | Abiraterone acetate formulation and methods of use | |
| JP7332549B2 (en) | How to suppress mount occurrence | |
| CN102202691B (en) | Lactose and cellulose-based tableting aid | |
| CN103356616A (en) | Bilastine-containing pharmaceutical composition and preparation method thereof | |
| WO2004004692A1 (en) | Processes for the preparation of oral dosage formulations of modafinil | |
| CN102292075A (en) | Pharmaceutical compositions with superior product performance and patient compliance | |
| CN106999600A (en) | Include the disintegrating particles composition for crushing lactose or lactose of pelletizing | |
| CN106551946A (en) | It is a kind of containing trifluorothymidine and hydrochloric acid for the pharmaceutical composition and preparation method than pyrimidine | |
| CN108420798A (en) | A kind of immediate release drug formulations of anti-coagulants and preparation method thereof | |
| JP6104038B2 (en) | Composite composition of crystalline cellulose | |
| CN106540266A (en) | A kind of vilazodone pharmaceutical composition and preparation method thereof | |
| CN112741819B (en) | Fluoxetine hydrochloride capsule and preparation method thereof | |
| TW200824711A (en) | Embedded micellar nanoparticles | |
| AU2013347264B2 (en) | Dispersible tablet | |
| JP2019112358A (en) | Cellulose including compact for suppressing separation segregation | |
| CN104352463A (en) | Ampicillin sodium dispersible tablet | |
| CN111214442B (en) | Apixaban co-micropowder | |
| CN104248769A (en) | Lurasidone pharmaceutical composition and preparation method thereof | |
| CN113599360B (en) | Lurasidone hydrochloride self-emulsifying solid preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20160707 Address after: 210042 Xuanwu District, Xuanwu District, Jiangsu, Nanjing No. 699 -18 Applicant after: Jiangsu Simcere Pharmaceutical Co., Ltd. Address before: 210042 Xuanwu District, Xuanwu District, Jiangsu, Nanjing No. 699 -18 Applicant before: Jiangsu Simcere Pharmaceutical Research Company Limited Applicant before: Jiangsu Simcere Pharmaceutical Co., Ltd. |
|
| CB03 | Change of inventor or designer information |
Inventor after: Ji Yuanxin Inventor after: Li Ling Inventor after: Ren Jinsheng Inventor after: Wang Qingsong Inventor after: Liu Chunhui Inventor after: Xu Xiangyang Inventor before: Ji Yuanxin Inventor before: Li Ling Inventor before: Wang Qingsong Inventor before: Liu Chunhui Inventor before: Xu Xiangyang |
|
| CB03 | Change of inventor or designer information | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |