CN104107163B - A kind of rifamicina VC Pharmaceutical composition injection preparation method - Google Patents
A kind of rifamicina VC Pharmaceutical composition injection preparation method Download PDFInfo
- Publication number
- CN104107163B CN104107163B CN201410251658.XA CN201410251658A CN104107163B CN 104107163 B CN104107163 B CN 104107163B CN 201410251658 A CN201410251658 A CN 201410251658A CN 104107163 B CN104107163 B CN 104107163B
- Authority
- CN
- China
- Prior art keywords
- water
- injection
- piston
- rifamicina
- communicated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention provides a kind of rifamicina VC Pharmaceutical composition injection preparation, is step as follows: 1. in parenteral solution, contain rifamicina 50g, vitamin C? the appropriate ratio feeding of 6.5g, sodium pyrosulfite 4g, propane diols 70ml and 5mol/L NaOH is for subsequent use; 2. the reactor in preparation method, feeding pipe and constant temperature water supply system are rinsed well for subsequent use with disodium ethylene diamine tetraacetate; 3. by the water for injection access water storage box of storage, water storage box is connected with constant temperature water for injection outlet pipe; 4. sodium pyrosulfite, vitamin C are inserted in reactor, obtain mixed liquor by adding propane diols to stir after mixing in constant temperature water for injection injection reactor; 5. in mixed liquor, add rifamicina, then add water for injection, add active carbon to stir; 6. the filling rifamicina VC Pharmaceutical composition parenteral solution of making after essence filter. Preparation method of the present invention is in order to reduce the harmful substance contents of rifamycin sodium injection.
Description
Technical field
The present invention relates to composition of medicine, is a kind of rifamicina VC Pharmaceutical composition injection preparation.
Background technology
Rifamicina is a kind of broad-spectrum antibiotic medicine, is used for the treatment of the disease that the gram-positive bacteriums such as streptococcus, pneumococcus, staphylococcus cause. Because its toxicity is humble, little to the side effect of other organ of human body, thereby can long-term prescription, and can merge and use with other antibiotic, be widely used clinically. Application quantity significantly rose in recent years, because rifamicina is by introducing medicine abroad, although domestic existing several medicines are looked forward to producing, can not meet the need of market. Although looking forward to all adopting rifamicina to do raw material, each medicine prepares rifamycin sodium injection, but make its product quality still have gap with the quality of imported medicine by the restriction of preparation technology and equipment in preparation process, particularly the control of its related substances in medicine is difficult to reach lower value, and its related substances in rifamycin sodium injection still exists larger gap with the content of imported product related substance.
Summary of the invention
The object of the invention is, provide a kind of rifamicina VC Pharmaceutical composition injection preparation, in order to reduce the harmful substance contents of rifamycin sodium injection.
The present invention for achieving the above object, is achieved through the following technical solutions: a kind of rifamicina VC Pharmaceutical composition injection preparation, and step is as follows:
1. in for subsequent use containing the appropriate ratio feeding of rifamicina 50g, vitamin C 6.5g, sodium pyrosulfite 4g, propane diols 70ml and 5mol/L NaOH in recipe quantity 1000ml parenteral solution;
2. the reactor made from metal material using in preparation method, feeding pipe and constant temperature water supply system are soaked after 25-35 minute with the disodium ethylene diamine tetraacetate of 0.02% concentration, rinse well, for subsequent use;
3. by the water storage box in the water for injection access constant temperature water supply system of 85 DEG C-95 DEG C of storage, water storage box is connected respectively with constant temperature water for injection outlet pipe by pipeline;
4. in the ratio of recipe quantity, sodium pyrosulfite, vitamin C are inserted in reactor, reactor inflated with nitrogen, open the valve of water for injection outlet pipe in constant temperature water supply system, the constant temperature water for injection of 39 DEG C is injected in reactor, the consumption of water for injection is 25% of total amount, after mixing, adds the propane diols of recipe quantity ratio, stir, obtain mixed liquor;
5. under nitrogen protection, in step mixed liquor 4., add rifamicina in the ratio of recipe quantity, then add 39 DEG C of waters for injection, the consumption of water for injection is 75% of total amount, stir down to dissolving completely, to 7-7.5, add 0.1%(W/V with 5mol/L NaOH adjust pH) active carbon stir 30 minutes, decarbonization filtering, adjust pH is 7-7.5;
6. with after the filter of 0.22um filter essence, filling, inflated with nitrogen before and after embedding, makes rifamicina VC Pharmaceutical composition parenteral solution for 20 minutes 102 DEG C of sterilizings. the constant temperature water supply system of step in 4. has a water storage box, the water for injection that the interior splendid attire of water storage box is 85 DEG C-95 DEG C, water storage box two bottom sides arranges respectively the first pipeline and second pipe, second pipe is connected with pipe for shell-and-tube exchanger journey arrival end, the pipe for shell-and-tube exchanger journey port of export is communicated with recycle control valve water inlet, pipe for shell-and-tube exchanger journey exit mounting temperature sensor, the refluxing opening of recycle control valve is communicated with second pipe, the delivery port of recycle control valve is communicated with the 3rd pipeline one end, the 3rd pipeline other end is communicated with the cooling water inlet of constant-temperature water mixing valve, first pipeline one end is communicated with the hot water inlet of constant-temperature water mixing valve, the mixed water exports of constant-temperature water mixing valve is communicated with water for injection outlet pipe, on water for injection outlet pipe, Water filling valve is installed, the water inlet of recycle control valve and refluxing opening are arranged in the housing sidewall of recycle control valve, water inlet and refluxing opening height in housing sidewall is crisscross arranged, the delivery port of recycle control valve is arranged on housing one end near water inlet, piston is installed in the housing of recycle control valve, negative pressure cavity is set in piston, piston side wall is offered liquid sucting port, liquid sucting port is communicated with negative pressure cavity, piston arranges seal near one end of delivery port, the piston other end is offered liquid outlet, liquid outlet is communicated with negative pressure cavity, rotor is set in negative pressure cavity, rotor is connected with piston by rotor field spider, rotor sidewall border arranges axial blade, seal cover is installed at rotor field spider top, battery and wireless transceiver are installed in seal cover, battery is all connected with rotor by circuit with wireless transceiver, seal cover is connected with the piston rod end of power cylinder, when piston moves to the extreme position of delivery port one end, seal seals delivery port, the liquid sucting port of piston side wall is communicated with the water inlet of the housing sidewall of recycle control valve, negative pressure cavity is communicated with by the liquid outlet of top land and the refluxing opening of recycle control valve simultaneously, when piston moves to the extreme position of refluxing opening one end, the water inlet of recycle control valve is communicated with delivery port, piston side wall seals refluxing opening simultaneously. described seal is cone seal piece, and the border, junction of delivery port and housing sets out watertight seal ring, and water outlet sealing ring endoporus is truncated cone shape hole, and cone seal piece matches with the truncated cone shape hole of water outlet sealing ring. the border, junction of refluxing opening and housing arranges annular groove, and backflow sealing ring is installed in annular groove, and backflow sealing ring is made up of elastomeric material, and backflow sealing ring protrudes from the madial wall of housing, and top land edge arranges annular slope.
Rifamicina complex structure, unstability be high, need to increase its stability with vitamin C combination, but vitamin C chemical property is very active, unstable too. therefore method of the present invention is easily to produce aborning according to rifamicina and vitamin C the method that the feature of degradation impurity provides. the content high effective liquid chromatography for measuring of the related substance in the rifamicina VC Pharmaceutical composition parenteral solution of preparing by method of the present invention, its content is lower than commercially available prod its related substances, and multiple batches of detection its related substances is consistent. rifamicina VC Pharmaceutical composition parenteral solution prepared by preparation method's of the present invention special process and parameter production efficiency and preparation cost all unaffected lower each raw material be uniformly dissolved, while dissolving at 39 DEG C, rifamycin sodium content after its chemical reaction does not reduce substantially, its related substances is extremely low, and stability is high, solve existing rifamycin sodium injection in industrialization, large-scale production cannot keep low temperature, the difficult problem that constant temperature is produced, preparation method of the present invention improves in existing preparation technology, do not need to change hardware production line, production cost is low.
Brief description of the drawings
Fig. 1 is the structural representation of constant temperature water supply system of the present invention; Fig. 2 is the structural representation of recycle control valve of the present invention, the state while being positioned at the extreme position of delivery port one end for piston shown in figure; Fig. 3 is the structural representation of recycle control valve of the present invention, the state while being positioned at the extreme position of refluxing opening one end for piston shown in figure; Fig. 4 is I portion structure for amplifying schematic diagram in Fig. 2.
Detailed description of the invention
A kind of rifamicina VC Pharmaceutical composition injection preparation of the present invention, step is as follows:
1. in for subsequent use containing the appropriate ratio feeding of rifamicina 50g, vitamin C 6.5g, sodium pyrosulfite 4g, propane diols 70ml and 5mol/L NaOH in recipe quantity 1000ml parenteral solution;
2. the reactor made from metal material using in preparation method, feeding pipe and constant temperature water supply system are soaked after 25-35 minute with the disodium ethylene diamine tetraacetate of 0.02% concentration, rinse well, for subsequent use;
3. by the water storage box in the water for injection access constant temperature water supply system of 85 DEG C-95 DEG C of storage, water storage box is connected respectively with constant temperature water for injection outlet pipe by pipeline;
4. in the ratio of recipe quantity, sodium pyrosulfite, vitamin C are inserted in reactor, reactor inflated with nitrogen, open water for injection outlet pipe valve in constant temperature water supply system, the constant temperature water for injection of 39 DEG C is injected in reactor, the consumption of water for injection is 25% of total consumption, after mixing, adds the propane diols of recipe quantity ratio, stir, obtain mixed liquor;
5. in step mixed liquor 4., add rifamicina in the ratio of recipe quantity, then add 39 DEG C of waters for injection, the consumption of water for injection is 75% of total consumption, stir down to dissolving completely, with 5mol/L NaOH adjust pH to 7-7.5, add 0.1%(W/V) active carbon stir 30 minutes, decarbonization filtering, adjust pH is 7-7.5;
6. with after the filter of 0.22um filter essence, filling, inflated with nitrogen before and after embedding, makes rifamicina VC Pharmaceutical composition parenteral solution for 20 minutes 102 DEG C of sterilizings.
The constant temperature water supply system of step in 4. has a water storage box 2, the water for injection that the interior splendid attire of water storage box 2 is 85 DEG C-95 DEG C, water storage box 2 two bottom sides arrange respectively the first pipeline 8 and second pipe 6, second pipe 6 is connected with shell-and-tube heat exchanger 4 tube side arrival ends, the shell-and-tube heat exchanger 4 tube side ports of export are communicated with recycle control valve 1 water inlet 12, shell-and-tube heat exchanger 4 tube side exit mounting temperature sensors 5, the refluxing opening 13 of recycle control valve 1 is communicated with second pipe 6, the delivery port 14 of recycle control valve 1 is communicated with the 3rd pipeline 7 one end, the 3rd pipeline 7 other ends are communicated with the cooling water inlet of constant-temperature water mixing valve 9, first pipeline 8 one end are communicated with the hot water inlet of constant-temperature water mixing valve 9, the mixed water exports of constant-temperature water mixing valve 9 is communicated with water for injection outlet pipe 10, Water filling valve 33 is installed on water for injection outlet pipe 10, the water inlet 12 of recycle control valve 1 and refluxing opening 13 are arranged on housing 11 sidewalls of recycle control valve 1, water inlet 12 and refluxing opening 13 height on housing 11 sidewalls is crisscross arranged, the delivery port 14 of recycle control valve 1 is arranged on housing 11 one end near water inlet 12, the interior installation piston 15 of housing 11 of recycle control valve 1, the interior negative pressure cavity 19 that arranges of piston 15, piston 15 sidewalls are offered liquid sucting port 20, liquid sucting port 20 is communicated with negative pressure cavity 19, piston 15 arranges seal 16 near one end of delivery port 14, piston 15 other ends are offered liquid outlet 22, liquid outlet 22 is communicated with negative pressure cavity 19, the interior rotor 23 that arranges of negative pressure cavity 19, rotor 23 is connected with piston 15 by rotor field spider 21, rotor 23 sidewall borders arrange axial blade, seal cover 25 is installed at rotor field spider 21 tops, the interior installation battery 26 of seal cover 25 and wireless transceiver 27, battery 26 is all connected with rotor 23 by circuit with wireless transceiver 27, seal cover 25 is connected with the piston rod end of power cylinder 28, when piston 15 moves to the extreme position of delivery port 14 one end, seal 16 seals delivery port 14, the liquid sucting port 20 of piston 15 sidewalls is communicated with the water inlet 12 of housing 11 sidewalls of recycle control valve 1, negative pressure cavity 19 is communicated with by the liquid outlet 22 at piston 15 tops and the refluxing opening 13 of recycle control valve 1 simultaneously, when piston 15 moves to the extreme position of refluxing opening 13 one end, the water inlet 12 of recycle control valve 1 is communicated with delivery port 14, piston 15 sidewalls seal refluxing opening 13 simultaneously. in figure, 29 is spacing rings.
The water temperature when water for injection of medicine enterprise is made from Preparation equipment is all more than 90 DEG C, and therefore at pharmaceutical field, except some must use the special biologic product of water at low temperature, in medicine preparation process, water for injection all stores under the environment of high temperature. And very easily there is degradation reaction in the less stable of rifamicina, in the preparation of parenteral solution, easily cause product content to reduce, its related substances increases. Degradation reaction and temperature have close relationship, and temperature is higher, and degradation reaction speed is just faster. The present situation that in the rifamycin sodium injection that current domestic pharmacy corporation is produced, impurity content is relatively high, constant product quality is poor is mainly accurate not by the temperature control in production technology, is difficult to that the degradation reaction of rifamicina is formed to effective inhibition and causes. Preparing rifamicina VC Pharmaceutical composition parenteral solution with preparation method's of the present invention special process is to dissolve and make at 39 DEG C and in the situation that not affecting production efficiency and preparation cost; rifamycin sodium content after its chemical reaction does not reduce substantially; its related substances is extremely low; and stability is high, solve the difficult problem that existing rifamycin sodium injection cannot keep low temperature, constant temperature to produce in industrialization, large-scale production. Constant temperature water supply system of the present invention for providing the water for injection of constant 39 DEG C in reactor, the degradation reaction speed of rifamicina is controlled to lower level, keep the product content in parenteral solution can not reduce, suppress the generation of related substance simultaneously, because the water temperature moment of water for injection keeps constant, therefore the product content in each batch of medicine can temperature influence and is changed, and makes the stability of product quality be promoted to higher level.
Current each pharmacy corporation is in the time regulating and controlling the temperature of water for injection, there is following several respects reason to cause it cannot accurately control water temperature: water for injection has the strict regulation of disinfecting on the one hand, in the time water for injection being lowered the temperature to processing, must adopt contactless heat exchanger and low-temperature receiver to carry out heat exchange, and the heat exchange efficiency of contactless heat exchanger is subject to the impact of the factor such as environment temperature, flow rate of liquid larger, water for injection temperature fluctuation range after cooling is larger, and this is to cause the uncontrollable principal element at reduced levels of related substance in rifamycin sodium injection; On the other hand, as the water for injection temperature after cooling is further carried out to accuracy controlling, between heat exchanger and reactor, the length of water for injection transfer pipeline need significantly increase, cause the further increasing influenced by ambient temperature of water for injection temperature, be still difficult to realize the accurate control to water for injection temperature.
Constant temperature water supply system of the present invention can solve the difficult problem running in the time that the temperature of water for injection is regulated and controled at present, the temperature of water for injection is realized accurately and being controlled, between heat exchanger and reactor, only there are the parts of recycle control valve 1, constant-temperature water mixing valve 9 and Water filling valve 33 these three small volumes simultaneously, only need tens centimetres of pipelines just can install, be not therefore substantially subject to the impact of environment temperature. when constant temperature water supply system is used, high temperature injection water in water storage box 2 enters shell-and-tube heat exchanger 4 through second pipe 6, carry out heat exchange with the low-temperature receiver in shell-and-tube heat exchanger 4 shell sides, when water for injection effuser shell heat exchanger 4 after cooling, the temperature of temperature sensor 5 Real-Time Monitoring waters for injection, if water for injection temperature is lower than 39 DEG C, piston 15 moves to the extreme position of refluxing opening 13 one end under the driving of power cylinder 28, the water inlet 12 of recycle control valve 1 is communicated with delivery port 14, refluxing opening 13 seals, temperature enters constant-temperature water mixing valve 9 lower than the water for injection of 39 DEG C along the 3rd pipeline 7, constant-temperature water mixing valve 9 mixes with temperature the high temperature injection water transporting by the first pipeline 8 lower than the water for injection of 39 DEG C, automatic governing becomes the water for injection input water for injection outlet pipe 10 of 39 DEG C, prepare medicine for reactor, after the heat exchange recording as temperature sensor 5, water for injection temperature is higher than 39 DEG C, piston 15 moves to the extreme position of delivery port 14 one end under the driving of power cylinder 28, seal 16 seals delivery port 14, water inlet 12 is by liquid sucting port 20, negative pressure cavity 19 and liquid outlet 22 are communicated with the refluxing opening 13 of recycle control valve 1, now refluxing opening 13 is identical with the fluid pressure of shell-and-tube heat exchanger 4 tube side import departments, rotor in negative pressure cavity 19 starts rotation, make the axial current of the interior generation of negative pressure cavity 19, drive the water for injection that shell-and-tube heat exchanger 4 flows out to flow back in second pipe 6, again lower the temperature through shell-and-tube heat exchanger 4, the temperature data being recorded by temperature sensor 5 again determines whether need again to reflux. said structure can be realized accurately and controlling the temperature of water for injection, is not substantially subject to the impact of environment temperature, higher in environment temperature, when shell-and-tube heat exchanger 4 cooling-down effects are not good, still can accurately provide the water for injection of steady temperature for reactor.
The present invention is in order to strengthen the sealing intensity at delivery port 14 and refluxing opening 13 places, can adopt following structure: described seal 16 is cone seal pieces, delivery port 14 sets out watertight seal ring 17 with the border, junction of housing 11, water outlet sealing ring 17 endoporus are truncated cone shape hole, and cone seal piece matches with the truncated cone shape hole of water outlet sealing ring 17. Refluxing opening 13 arranges annular groove 30 with the border, junction of housing 11, the interior installation backflow of annular groove 30 sealing ring 31, backflow sealing ring 31 is made up of elastomeric material, and backflow sealing ring 31 protrudes from the madial wall of housing 11, and piston 15 top arrange annular slope 32. Cone seal piece and endoporus are that the water outlet sealing ring 17 of truncated cone shape matches and has larger sealing area, the elasticity backflow sealing ring 31 that protrudes from housing 11 is subject to piston 15 crimps in the time of sealing, there is higher sealing load, simultaneously above-mentioned two place's hermetically-sealed constructions also have after aging or wearing and tearing can auto-compensation, the impregnable characteristic of sealing effectiveness, be conducive to service life of extension device.
The mensuration of rifamicina VC Pharmaceutical composition parenteral solution related substance prepared by the present invention adopts high performance liquid chromatography, and the rifamycin sodium content of mensuration is labelled amount 102%, and the measurement result of related substance is as follows:
The above results shows, its its related substances of the product of preparing by the inventive method is starkly lower than commercially available prod. It has good stability, and is better than commercially available prod.
Claims (4)
1. a rifamicina VC Pharmaceutical composition injection preparation, is characterized in that: step is as follows:
1. in for subsequent use containing the appropriate ratio feeding of rifamicina 50g, vitamin C 6.5g, sodium pyrosulfite 4g, propane diols 70ml and 5mol/L NaOH in recipe quantity 1000ml parenteral solution;
2. the reactor made from metal material using in preparation method, feeding pipe and constant temperature water supply system are soaked after 25-35 minute with the disodium ethylene diamine tetraacetate of 0.02% concentration, rinse well, for subsequent use;
3. by the water storage box in the water for injection access constant temperature water supply system of 85 DEG C-95 DEG C of storage, water storage box is connected respectively with constant temperature water for injection outlet pipe by pipeline;
4. in the ratio of recipe quantity, sodium pyrosulfite, vitamin C are inserted in reactor, reactor inflated with nitrogen, open the valve of water for injection outlet pipe in constant temperature water supply system, the constant temperature water for injection of 39 DEG C is injected in reactor, the consumption of water for injection is 25% of total amount, after mixing, adds the propane diols of recipe quantity ratio, stir, obtain mixed liquor;
5. under nitrogen protection, in step mixed liquor 4., add rifamicina in the ratio of recipe quantity, then add 39 DEG C of waters for injection, the consumption of water for injection is 75% of total amount, stir down to dissolving completely, to 7-7.5, add 0.1%(W/V with 5mol/L NaOH adjust pH) active carbon stir 30 minutes, decarbonization filtering, adjust pH is 7-7.5;
6. with after the filter of 0.22um filter essence, filling, inflated with nitrogen before and after embedding, makes rifamicina VC Pharmaceutical composition parenteral solution for 20 minutes 102 DEG C of sterilizings.
2. a kind of rifamicina VC Pharmaceutical composition injection preparation according to claim 1, it is characterized in that: the constant temperature water supply system of step in 4. has a water storage box (2), the water for injection that the interior splendid attire of water storage box (2) is 85 DEG C-95 DEG C, water storage box (2) two bottom sides arranges respectively the first pipeline (8) and second pipe (6), second pipe (6) is connected with shell-and-tube heat exchanger (4) tube side arrival end, shell-and-tube heat exchanger (4) the tube side port of export is communicated with recycle control valve (1) water inlet (12), shell-and-tube heat exchanger (4) tube side exit mounting temperature sensor (5), the refluxing opening (13) of recycle control valve (1) is communicated with second pipe (6), the delivery port (14) of recycle control valve (1) is communicated with the 3rd pipeline (7) one end, the 3rd pipeline (7) other end is communicated with the cooling water inlet of constant-temperature water mixing valve (9), the first pipeline (8) one end is communicated with the hot water inlet of constant-temperature water mixing valve (9), the mixed water exports of constant-temperature water mixing valve (9) is communicated with water for injection outlet pipe (10), the upper Water filling valve (33) of installing of water for injection outlet pipe (10), the water inlet (12) of recycle control valve (1) and refluxing opening (13) are arranged on housing (11) sidewall of recycle control valve (1), water inlet (12) and refluxing opening (13) height on housing (11) sidewall is crisscross arranged, the delivery port (14) of recycle control valve (1) is arranged on housing (11) one end near water inlet (12), piston (15) is installed in the housing (11) of recycle control valve (1), negative pressure cavity (19) is set in piston (15), piston (15) sidewall is offered liquid sucting port (20), liquid sucting port (20) is communicated with negative pressure cavity (19), piston (15) arranges seal (16) near one end of delivery port (14), piston (15) other end is offered liquid outlet (22), liquid outlet (22) is communicated with negative pressure cavity (19), rotor (23) is set in negative pressure cavity (19), rotor (23) is connected with piston (15) by rotor field spider (21), rotor (23) sidewall border arranges axial blade, seal cover (25) is installed at rotor field spider (21) top, battery (26) and wireless transceiver (27) are installed in seal cover (25), battery (26) is all connected with rotor (23) by circuit with wireless transceiver (27), seal cover (25) is connected with the piston rod end of power cylinder (28), when piston (15) moves to the extreme position of delivery port (14) one end, seal (16) seals delivery port (14), the liquid sucting port (20) of piston (15) sidewall is communicated with the water inlet (12) of housing (11) sidewall of recycle control valve (1), negative pressure cavity (19) is communicated with by the liquid outlet (22) at piston (15) top and the refluxing opening (13) of recycle control valve (1) simultaneously, when piston (15) moves to the extreme position of refluxing opening (13) one end, the water inlet (12) of recycle control valve (1) is communicated with delivery port (14), piston (15) sidewall seals refluxing opening (13) simultaneously.
3. a kind of rifamicina VC Pharmaceutical composition injection preparation according to claim 2, it is characterized in that: described seal (16) is cone seal piece, delivery port (14) sets out watertight seal ring (17) with the border, junction of housing (11), water outlet sealing ring (17) endoporus is truncated cone shape hole, and cone seal piece matches with the truncated cone shape hole of water outlet sealing ring (17).
4. a kind of rifamicina VC Pharmaceutical composition injection preparation according to claim 2, it is characterized in that: refluxing opening (13) arranges annular groove (30) with the border, junction of housing (11), backflow sealing ring (31) is installed in annular groove (30), backflow sealing ring (31) is made up of elastomeric material, backflow sealing ring (31) protrudes from the madial wall of housing (11), and piston (15) top arranges annular slope (32).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410251658.XA CN104107163B (en) | 2014-02-28 | 2014-06-09 | A kind of rifamicina VC Pharmaceutical composition injection preparation method |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2014100710049 | 2014-02-28 | ||
| CN201410071004.9 | 2014-02-28 | ||
| CN201410071004 | 2014-02-28 | ||
| CN201410251658.XA CN104107163B (en) | 2014-02-28 | 2014-06-09 | A kind of rifamicina VC Pharmaceutical composition injection preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104107163A CN104107163A (en) | 2014-10-22 |
| CN104107163B true CN104107163B (en) | 2016-05-18 |
Family
ID=51704285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410251658.XA Active CN104107163B (en) | 2014-02-28 | 2014-06-09 | A kind of rifamicina VC Pharmaceutical composition injection preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104107163B (en) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE458505B (en) * | 1979-07-10 | 1989-04-10 | Lepetit Spa | APPLICATION OF RIFAMYCIN SV AND SALTS THEREOF PREPARING A PREPARATION FOR TREATMENT OF REUMATOID ARTHRITIS AND CERTAIN SALTS AND THEIR PREPARATION |
| CN100344282C (en) * | 2005-10-09 | 2007-10-24 | 沈阳双鼎制药有限公司 | Method for preparing rifamicina injecta |
| CN101152174B (en) * | 2007-09-11 | 2011-12-14 | 沈阳药科大学 | Stable rifamycin sodium injection prescription and preparing method of the same |
| CN101642429A (en) * | 2008-08-06 | 2010-02-10 | 郭瑞 | Method for preparing stable rifamycin sodium injection and rifamycin sodium and sodium chloride (glucose) injection |
| CN101708155A (en) * | 2009-11-27 | 2010-05-19 | 河南辅仁怀庆堂制药有限公司 | Rifamycin sodium injection and preparation method thereof |
-
2014
- 2014-06-09 CN CN201410251658.XA patent/CN104107163B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN104107163A (en) | 2014-10-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN204051640U (en) | MEAM synthesis reactor | |
| CN103830172A (en) | Preparation method of lincomycin hydrochloride injection | |
| CN104107163B (en) | A kind of rifamicina VC Pharmaceutical composition injection preparation method | |
| CN112968164A (en) | Experimental method for preparing lithium battery positive electrode material precursor | |
| CN105712865A (en) | Solid aluminum citrate cross-linking agent, preparation method and application thereof | |
| CN101635322B (en) | Method and device for chain velvet making of multi-crystalline solar cell | |
| CN201523023U (en) | Chain type wool-making device of polycrystal solar battery slice | |
| CN205559795U (en) | Double -face mechanical sealing structure | |
| CN208500947U (en) | A kind of liquid spawn conveying equipment | |
| CN204891861U (en) | Novel reation kettle | |
| CN103759801A (en) | Filling type large weight and method for manufacturing filling type large weight | |
| CN104013572A (en) | Process for preparing chloramphenicol injection | |
| CN214579056U (en) | Anti-abrasion type sealing rotary valve device | |
| CN209974924U (en) | Electrolytic copper foil silane adding device | |
| CN210808587U (en) | Structure for rice planting experiments | |
| CN108397157A (en) | A kind of normal pressure constant current chemicals dosing plant | |
| CN206325634U (en) | A kind of new horizontal sand mill | |
| CN104000833B (en) | A kind of vitamin D2With calcium levulinate injection composition and preparation method thereof | |
| CN205838736U (en) | Generator stator cooling water micro-basification system | |
| CN210400487U (en) | Flowmeter for water and fertilizer integrated irrigation and fertilization system | |
| CN204591221U (en) | A kind of some drip chemical adder | |
| CN205807851U (en) | A kind of mixed water-bound of novel water-water jet | |
| CN106145208A (en) | A kind of circulating water treatment automatic medicine adding apparatus | |
| CN204589154U (en) | A kind of fermentation using bacteria tank | |
| CN221322368U (en) | Gas injection and brine discharge device for communicating well salt cavern gas storage |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |