CN104107163A - Preparing method of rifamycin sodium-VC pharmaceutical composition injection - Google Patents
Preparing method of rifamycin sodium-VC pharmaceutical composition injection Download PDFInfo
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- CN104107163A CN104107163A CN201410251658.XA CN201410251658A CN104107163A CN 104107163 A CN104107163 A CN 104107163A CN 201410251658 A CN201410251658 A CN 201410251658A CN 104107163 A CN104107163 A CN 104107163A
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Abstract
A preparing method of a rifamycin sodium-VC pharmaceutical composition injection is provided. The preparing method includes: (1) preparing raw materials according to a ratio that the injection comprises 50 g of rifamycin sodium, 6.5 g of vitamin C, 4 g of sodium pyrosulfite, 70 mL of propanediol and a proper amount of sodium hydroxide having a concentration of 5 mol/L, and keeping for further use; (2) washing a reactor, a conveying pipeline and a constant-temperature water supply system in the preparing method with disodium ethylenediaminetetraacetate dihydrate, and reserving for further use; (3) connecting stored injection water into a water storage tank so that the water storage tank is connected to a constant-temperature injection water discharging pipe; (4) adding the sodium pyrosulfite and the vitamin C into the reactor, injecting constant-temperature injection water into the reactor, mixing uniformly, adding the propanediol and stirring uniformly to obtain a liquid mixture; (5) adding the rifamycin sodium into the liquid mixture, adding the injection water, adding activated carbon, and stirring; and (6) performing refined filtration and filling to obtain the rifamycin sodium-VC pharmaceutical composition injection. The preparing method is used for decreasing the content of harmful compounds in the rifamycin sodium injection.
Description
Technical field
The present invention relates to composition of medicine, is a kind of rifamicina VC Pharmaceutical composition injection preparation.
Background technology
Rifamicina is a kind of broad ectrum antibiotic medicine, is used for the treatment of the disease that the gram-positive bacteriums such as streptococcus, streptococcus pneumoniae, staphylococcus cause.Because its toxicity is humble, little to the side effect of other organ of human body, thereby can long-term prescription, and can merge and use with other antibiotic, be widely used clinically.Application quantity significantly rose in recent years, because rifamicina is by introducing medicine abroad, although domestic existing several medicines are looked forward to producing, can not meet the need of market.Although all adopting rifamicina to do raw material, each medicine enterprise prepares rifamycin sodium injection, but the restriction by preparation technology and equipment in preparation process makes its product quality still have gap with the quality of imported medicine, particularly the control of its related substances in medicine is difficult to reach lower value, and its related substances in rifamycin sodium injection still exists larger gap with the content of imported product related substance.
Summary of the invention
The object of the invention is, provide a kind of rifamicina VC Pharmaceutical composition injection preparation, in order to reduce the harmful substance contents of rifamycin sodium injection.
The present invention for achieving the above object, is achieved through the following technical solutions: a kind of rifamicina VC Pharmaceutical composition injection preparation, and step is as follows:
1. in standby containing the appropriate ratio feeding of rifamicina 50g, vitamin C 6.5g, sodium pyrosulfite 4g, propylene glycol 70ml and 5mol/L sodium hydroxide in recipe quantity 1000ml injection;
2. the reactor made from metal material using in preparation method, feeding pipe and constant temperature water supply system are soaked after 25-35 minute with the disodiumedetate of 0.02% concentration, rinse well, standby;
3. by the water storage box in the water for injection access constant temperature water supply system of 85 ℃-95 ℃ of storing, water storage box is connected respectively with constant temperature water for injection outlet pipe by pipeline;
4. in the ratio of recipe quantity, sodium pyrosulfite, vitamin C are inserted in reactor, reactor inflated with nitrogen, open the valve of water for injection outlet pipe in constant temperature water supply system, the constant temperature water for injection of 39 ℃ is injected in reactor, the consumption of water for injection is 25% of total amount, after mix homogeneously, adds the propylene glycol of recipe quantity ratio, stir, obtain mixed liquor;
5. under nitrogen protection, in the ratio of recipe quantity, in step mixed liquor 4., add rifamicina, then add 39 ℃ of waters for injection, the consumption of water for injection is 75% of total amount, stirring, down to dissolving completely, to 7-7.5, adds 0.1%(W/V with 5mol/L sodium hydroxide adjust pH) active carbon stir 30 minutes, decarbonization filtering, adjust pH is 7-7.5;
6. use after 0.22um filter fine straining, fill, inflated with nitrogen before and after embedding, makes rifamicina VC Pharmaceutical composition injection for 20 minutes 102 ℃ of sterilizings.The constant temperature water supply system of step in 4. has a water storage box, the water for injection that the interior splendid attire of water storage box is 85 ℃-95 ℃, water storage box two bottom sides arranges respectively the first pipeline and second pipe, second pipe is connected with pipe for shell-and-tube exchanger journey arrival end, the pipe for shell-and-tube exchanger journey port of export is communicated with recycle control valve water inlet, pipe for shell-and-tube exchanger journey exit mounting temperature sensor, the refluxing opening of recycle control valve is communicated with second pipe, the outlet of recycle control valve is communicated with the 3rd pipeline one end, the 3rd pipeline other end is communicated with the cooling water inlet of constant-temperature water mixing valve, first pipeline one end is communicated with the hot water inlet of constant-temperature water mixing valve, the mixed water exports of constant-temperature water mixing valve is communicated with water for injection outlet pipe, on water for injection outlet pipe, Water filling valve is installed, the water inlet of recycle control valve and refluxing opening are arranged in the housing sidewall of recycle control valve, water inlet and refluxing opening height in housing sidewall is crisscross arranged, the outlet of recycle control valve is arranged on housing near one end of water inlet, piston is installed in the housing of recycle control valve, negative pressure cavity is set in piston, piston side wall is offered liquid sucting port, liquid sucting port is communicated with negative pressure cavity, piston arranges seal near one end of outlet, the piston other end is offered liquid outlet, liquid outlet is communicated with negative pressure cavity, rotor is set in negative pressure cavity, rotor is connected with piston by rotor field spider, rotor sidewall border arranges axial blade, seal cover is installed at rotor field spider top, battery and wireless transceiver are installed in seal cover, battery is all connected with rotor by circuit with wireless transceiver, seal cover is connected with the piston rod end of power cylinder, when piston moves to the extreme position of outlet one end, seal seals outlet, the liquid sucting port of piston side wall is communicated with the water inlet of the housing sidewall of recycle control valve, negative pressure cavity is communicated with by the liquid outlet of top land and the refluxing opening of recycle control valve simultaneously, when piston moves to the extreme position of refluxing opening one end, the water inlet of recycle control valve is communicated with outlet, piston side wall seals refluxing opening simultaneously.Described seal is cone seal piece, and the border, junction of outlet and housing sets out watertight seal ring, and water outlet sealing ring endoporus is truncated cone shape hole, and cone seal piece matches with the truncated cone shape hole of water outlet sealing ring.The border, junction of refluxing opening and housing arranges annular groove, and backflow sealing ring is installed in annular groove, and backflow sealing ring is made by elastomeric material, and backflow sealing ring protrudes from the medial wall of housing, and top land edge arranges annular slope.
Rifamicina complex structure, unstability be high, need to increase its stability with vitamin C combination, but vitamin C chemical property is very active, unstable too.Therefore method of the present invention is easily to produce aborning according to rifamicina and vitamin C the method that the feature of degradation impurity provides.The content high effective liquid chromatography for measuring of the related substance in the rifamicina VC Pharmaceutical composition injection of preparing by method of the present invention, its content is lower than commercially available prod its related substances, and multiple batches of detection its related substances is consistent.All unaffected lower each material dissolution is even at production efficiency and preparation cost for rifamicina VC Pharmaceutical composition injection prepared by the special process of preparation method of the present invention and parameter, while dissolving at 39 ℃, rifamycin sodium content after its chemical reaction does not reduce substantially, its related substances is extremely low, and stability is high, solved existing rifamycin sodium injection in industrialization, large-scale production cannot keep low temperature, the difficult problem that constant temperature is produced, preparation method of the present invention is improved in existing preparation technology, do not need to change hardware production line, production cost is low.
Accompanying drawing explanation
Fig. 1 is the structural representation of constant temperature water supply system of the present invention; Fig. 2 is the structural representation of recycle control valve of the present invention, the state while being positioned at the extreme position of outlet one end for piston shown in figure; Fig. 3 is the structural representation of recycle control valve of the present invention, the state while being positioned at the extreme position of refluxing opening one end for piston shown in figure; Fig. 4 is I portion structure for amplifying schematic diagram in Fig. 2.
The specific embodiment
A kind of rifamicina VC Pharmaceutical composition injection preparation of the present invention, step is as follows:
1. in standby containing the appropriate ratio feeding of rifamicina 50g, vitamin C 6.5g, sodium pyrosulfite 4g, propylene glycol 70ml and 5mol/L sodium hydroxide in recipe quantity 1000ml injection;
2. the reactor made from metal material using in preparation method, feeding pipe and constant temperature water supply system are soaked after 25-35 minute with the disodiumedetate of 0.02% concentration, rinse well, standby;
3. by the water storage box in the water for injection access constant temperature water supply system of 85 ℃-95 ℃ of storing, water storage box is connected respectively with constant temperature water for injection outlet pipe by pipeline;
4. in the ratio of recipe quantity, sodium pyrosulfite, vitamin C are inserted in reactor, reactor inflated with nitrogen, open water for injection outlet pipe valve in constant temperature water supply system, the constant temperature water for injection of 39 ℃ is injected in reactor, the consumption of water for injection is 25% of total consumption, after mix homogeneously, adds the propylene glycol of recipe quantity ratio, stir, obtain mixed liquor;
5. in the ratio of recipe quantity, in step mixed liquor 4., add rifamicina, then add 39 ℃ of waters for injection, the consumption of water for injection is 75% of total consumption, stirring is down to dissolving completely, with 5mol/L sodium hydroxide adjust pH to 7-7.5, add 0.1%(W/V) active carbon stir 30 minutes, decarbonization filtering, adjust pH is 7-7.5;
6. use after 0.22um filter fine straining, fill, inflated with nitrogen before and after embedding, makes rifamicina VC Pharmaceutical composition injection for 20 minutes 102 ℃ of sterilizings.
The constant temperature water supply system of step in 4. has a water storage box 2, the water for injection that the interior splendid attire of water storage box 2 is 85 ℃-95 ℃, water storage box 2 two bottom sides arrange respectively the first pipeline 8 and second pipe 6, second pipe 6 is connected with shell-and-tube heat exchanger 4 tube side arrival ends, the shell-and-tube heat exchanger 4 tube side ports of export are communicated with recycle control valve 1 water inlet 12, shell-and-tube heat exchanger 4 tube side exit mounting temperature sensors 5, the refluxing opening 13 of recycle control valve 1 is communicated with second pipe 6, the outlet 14 of recycle control valve 1 is communicated with the 3rd pipeline 7 one end, the 3rd pipeline 7 other ends are communicated with the cooling water inlet of constant-temperature water mixing valve 9, first pipeline 8 one end are communicated with the hot water inlet of constant-temperature water mixing valve 9, the mixed water exports of constant-temperature water mixing valve 9 is communicated with water for injection outlet pipe 10, Water filling valve 33 is installed on water for injection outlet pipe 10, the water inlet 12 of recycle control valve 1 and refluxing opening 13 are arranged on housing 11 sidewalls of recycle control valve 1, water inlet 12 and refluxing opening 13 height on housing 11 sidewalls is crisscross arranged, the outlet 14 of recycle control valve 1 is arranged on housing 11 near one end of water inlet 12, the interior installation piston 15 of housing 11 of recycle control valve 1, the interior negative pressure cavity 19 that arranges of piston 15, piston 15 sidewalls are offered liquid sucting port 20, liquid sucting port 20 is communicated with negative pressure cavity 19, piston 15 arranges seal 16 near one end of outlet 14, piston 15 other ends are offered liquid outlet 22, liquid outlet 22 is communicated with negative pressure cavity 19, the interior rotor 23 that arranges of negative pressure cavity 19, rotor 23 is connected with piston 15 by rotor field spider 21, rotor 23 sidewall borders arrange axial blade, seal cover 25 is installed at rotor field spider 21 tops, the interior installation battery 26 of seal cover 25 and wireless transceiver 27, battery 26 is all connected with rotor 23 by circuit with wireless transceiver 27, seal cover 25 is connected with the piston rod end of power cylinder 28, when piston 15 moves to the extreme position of outlet 14 one end, seal 16 is by outlet 14 sealings, the liquid sucting port 20 of piston 15 sidewalls is communicated with the water inlet 12 of housing 11 sidewalls of recycle control valve 1, negative pressure cavity 19 is communicated with by the liquid outlet 22 at piston 15 tops and the refluxing opening 13 of recycle control valve 1 simultaneously, when piston 15 moves to the extreme position of refluxing opening 13 one end, the water inlet 12 of recycle control valve 1 is communicated with outlet 14, piston 15 sidewalls are by refluxing opening 13 sealings simultaneously.
The water temperature when water for injection of medicine enterprise is made from Preparation equipment is all more than 90 ℃, and therefore at pharmaceutical field, except some must use the special biological preparation of water at low temperature, in medicine preparation process, water for injection all stores under the environment of high temperature.And very easily there is degradation reaction in the less stable of rifamicina, in the preparation of injection, easily cause product content to reduce, its related substances increases.Degradation reaction and temperature have close relationship, and temperature is higher, and degradation reaction speed is just faster.The present situation that in the rifamycin sodium injection that current domestic pharmacy corporation is produced, impurity content is relatively high, constant product quality is poor is mainly that the temperature control in production technology is accurate not, is difficult to that the degradation reaction of rifamicina is formed to effective inhibition and causes.With the special process of preparation method of the present invention, preparing rifamicina VC Pharmaceutical composition injection is to dissolve and make at 39 ℃ and in the situation that not affecting production efficiency and preparation cost; rifamycin sodium content after its chemical reaction does not reduce substantially; its related substances is extremely low; and stability is high, solved the difficult problem that existing rifamycin sodium injection cannot keep low temperature, constant temperature to produce in industrialization, large-scale production.Constant temperature water supply system of the present invention for providing the water for injection of constant 39 ℃ in reactor, by the degradation reaction rate controlled of rifamicina in lower level, keep the product content in injection can not reduce, suppress the generation of related substance simultaneously, because the water temperature of water for injection keeps constant constantly, therefore the product content in each batch of medicine can temperature influence and change, and makes the stability of product quality be promoted to higher level.
Each pharmacy corporation is when regulating and controlling the temperature of water for injection at present, there is following several respects reason to cause it cannot accurately control water temperature: water for injection has the strict regulation of disinfecting on the one hand, when water for injection being lowered the temperature to processing, must adopt contactless heat exchanger and low-temperature receiver to carry out heat exchange, and the heat exchange efficiency of contactless heat exchanger is subject to the impact of the factors such as ambient temperature, flow rate of liquid larger, water for injection temperature fluctuation range after cooling is larger, and this is to cause the uncontrollable principal element at reduced levels of related substance in rifamycin sodium injection; On the other hand, as the water for injection temperature after cooling is further carried out to accuracy controlling, between heat exchanger and reactor, the length of water for injection transfer pipeline need significantly increase, cause the further increasing influenced by ambient temperature of water for injection temperature, be still difficult to realize the accurate control to water for injection temperature.
Constant temperature water supply system of the present invention can solve the difficult problem running into when the temperature of water for injection is regulated and controled at present, the temperature of water for injection is realized accurately and being controlled, between heat exchanger and reactor, only there are the parts of recycle control valve 1, constant-temperature water mixing valve 9 and Water filling valve 33 these three small volumes simultaneously, only need tens centimetres of pipelines just can install, be not therefore substantially subject to the impact of ambient temperature.When constant temperature water supply system is used, high temperature injection water in water storage box 2 enters shell-and-tube heat exchanger 4 through second pipe 6, carry out heat exchange with the low-temperature receiver in shell-and-tube heat exchanger 4 shell sides, during water for injection effuser shell heat exchanger 4 after cooling, the temperature of temperature sensor 5 Real-Time Monitoring waters for injection, if water for injection temperature is lower than 39 ℃, piston 15 moves to the extreme position of refluxing opening 13 one end under the driving of power cylinder 28, the water inlet 12 of recycle control valve 1 is communicated with outlet 14, refluxing opening 13 sealings, temperature enters constant-temperature water mixing valve 9 lower than the water for injection of 39 ℃ along the 3rd pipeline 7, constant-temperature water mixing valve 9 mixes the high temperature injection water transporting by the first pipeline 8 with the water for injection of temperature lower than 39 ℃, automatic governing becomes the water for injection input water for injection outlet pipe 10 of 39 ℃, for reactor, prepare medicine, after the heat exchange recording as temperature sensor 5, water for injection temperature is higher than 39 ℃, piston 15 moves to the extreme position of outlet 14 one end under the driving of power cylinder 28, seal 16 is by outlet 14 sealings, water inlet 12 is by liquid sucting port 20, negative pressure cavity 19 and liquid outlet 22 are communicated with the refluxing opening 13 of recycle control valve 1, now refluxing opening 13 is identical with the fluid pressure of shell-and-tube heat exchanger 4 tube side import departments, rotor in negative pressure cavity 19 starts rotation, make the axial current of the interior generation of negative pressure cavity 19, drive the water for injection that shell-and-tube heat exchanger 4 flows out to flow back in second pipe 6, through shell-and-tube heat exchanger 4, again lower the temperature, the temperature data being recorded by temperature sensor 5 again determines whether need again to reflux.Said structure can be realized accurately and controlling the temperature of water for injection, is not substantially subject to the impact of ambient temperature, higher in ambient temperature, when shell-and-tube heat exchanger 4 cooling-down effects are not good, still can accurately provide the water for injection of steady temperature for reactor.
The present invention is in order to strengthen the sealing intensity at outlet 14 and refluxing opening 13 places, can adopt following structure: described seal 16 is cone seal pieces, outlet 14 sets out watertight seal ring 17 with the border, junction of housing 11, water outlet sealing ring 17 endoporus are truncated cone shape hole, and cone seal piece matches with the truncated cone shape hole of water outlet sealing ring 17.Refluxing opening 13 arranges annular groove 30 with the border, junction of housing 11, the interior installation backflow of annular groove 30 sealing ring 31, backflow sealing ring 31 is made by elastomeric material, and backflow sealing ring 31 protrudes from the medial wall of housing 11, and piston 15 top arrange annular slope 32.Cone seal piece and endoporus are that the water outlet sealing ring 17 of truncated cone shape matches and has larger sealing area, the elasticity backflow sealing ring 31 that protrudes from housing 11 is subject to piston 15 crimps when sealing, there is higher sealing load, simultaneously above-mentioned two place's hermetically-sealed constructions also have after aging or wearing and tearing can auto-compensation, the impregnable characteristic of sealing effectiveness, be conducive to service life of extension device.
The mensuration of rifamicina VC Pharmaceutical composition injection related substance prepared by the present invention adopts high performance liquid chromatography, and the rifamycin sodium content of mensuration is labelled amount 102%, and the measurement result of related substance is as follows:
The above results shows, its its related substances of the product of preparing by the inventive method is starkly lower than commercially available prod.It has good stability, and is better than commercially available prod.In figure, 29 is spacing rings.
Claims (4)
1. a rifamicina VC Pharmaceutical composition injection preparation, is characterized in that: step is as follows:
1. in standby containing the appropriate ratio feeding of rifamicina 50g, vitamin C 6.5g, sodium pyrosulfite 4g, propylene glycol 70ml and 5mol/L sodium hydroxide in recipe quantity 1000ml injection;
2. the reactor made from metal material using in preparation method, feeding pipe and constant temperature water supply system are soaked after 25-35 minute with the disodiumedetate of 0.02% concentration, rinse well, standby;
3. by the water storage box in the water for injection access constant temperature water supply system of 85 ℃-95 ℃ of storing, water storage box is connected respectively with constant temperature water for injection outlet pipe by pipeline;
4. in the ratio of recipe quantity, sodium pyrosulfite, vitamin C are inserted in reactor, reactor inflated with nitrogen, open the valve of water for injection outlet pipe in constant temperature water supply system, the constant temperature water for injection of 39 ℃ is injected in reactor, the consumption of water for injection is 25% of total amount, after mix homogeneously, adds the propylene glycol of recipe quantity ratio, stir, obtain mixed liquor;
5. under nitrogen protection, in the ratio of recipe quantity, in step mixed liquor 4., add rifamicina, then add 39 ℃ of waters for injection, the consumption of water for injection is 75% of total amount, stirring, down to dissolving completely, to 7-7.5, adds 0.1%(W/V with 5mol/L sodium hydroxide adjust pH) active carbon stir 30 minutes, decarbonization filtering, adjust pH is 7-7.5;
6. use after 0.22um filter fine straining, fill, inflated with nitrogen before and after embedding, makes rifamicina VC Pharmaceutical composition injection for 20 minutes 102 ℃ of sterilizings.
2. a kind of rifamicina VC Pharmaceutical composition injection preparation according to claim 1, it is characterized in that: the constant temperature water supply system of step in 4. has a water storage box (2), the water for injection that the interior splendid attire of water storage box (2) is 85 ℃-95 ℃, water storage box (2) two bottom sides arranges respectively the first pipeline (8) and second pipe (6), second pipe (6) is connected with shell-and-tube heat exchanger (4) tube side arrival end, shell-and-tube heat exchanger (4) the tube side port of export is communicated with recycle control valve (1) water inlet (12), shell-and-tube heat exchanger (4) tube side exit mounting temperature sensor (5), the refluxing opening (13) of recycle control valve (1) is communicated with second pipe (6), the outlet (14) of recycle control valve (1) is communicated with the 3rd pipeline (7) one end, the 3rd pipeline (7) other end is communicated with the cooling water inlet of constant-temperature water mixing valve (9), the first pipeline (8) one end is communicated with the hot water inlet of constant-temperature water mixing valve (9), the mixed water exports of constant-temperature water mixing valve (9) is communicated with water for injection outlet pipe (10), the upper Water filling valve (33) of installing of water for injection outlet pipe (10), the water inlet (12) of recycle control valve (1) and refluxing opening (13) are arranged on housing (11) sidewall of recycle control valve (1), water inlet (12) and refluxing opening (13) height on housing (11) sidewall is crisscross arranged, the outlet (14) of recycle control valve (1) is arranged on housing (11) near one end of water inlet (12), piston (15) is installed in the housing (11) of recycle control valve (1), negative pressure cavity (19) is set in piston (15), piston (15) sidewall is offered liquid sucting port (20), liquid sucting port (20) is communicated with negative pressure cavity (19), piston (15) arranges seal (16) near one end of outlet (14), piston (15) other end is offered liquid outlet (22), liquid outlet (22) is communicated with negative pressure cavity (19), rotor (23) is set in negative pressure cavity (19), rotor (23) is connected with piston (15) by rotor field spider (21), rotor (23) sidewall border arranges axial blade, seal cover (25) is installed at rotor field spider (21) top, battery (26) and wireless transceiver (27) are installed in seal cover (25), battery (26) is all connected with rotor (23) by circuit with wireless transceiver (27), seal cover (25) is connected with the piston rod end of power cylinder (28), when piston (15) moves to the extreme position of outlet (14) one end, seal (16) seals outlet (14), the liquid sucting port (20) of piston (15) sidewall is communicated with the water inlet (12) of housing (11) sidewall of recycle control valve (1), negative pressure cavity (19) is communicated with by the liquid outlet (22) at piston (15) top and the refluxing opening (13) of recycle control valve (1) simultaneously, when piston (15) moves to the extreme position of refluxing opening (13) one end, the water inlet (12) of recycle control valve (1) is communicated with outlet (14), piston (15) sidewall seals refluxing opening (13) simultaneously.
3. a kind of rifamicina VC Pharmaceutical composition injection preparation according to claim 2, it is characterized in that: described seal (16) is cone seal piece, outlet (14) sets out watertight seal ring (17) with the border, junction of housing (11), water outlet sealing ring (17) endoporus is truncated cone shape hole, and cone seal piece matches with the truncated cone shape hole of water outlet sealing ring (17).
4. a kind of rifamicina VC Pharmaceutical composition injection preparation according to claim 2, it is characterized in that: refluxing opening (13) arranges annular groove (30) with the border, junction of housing (11), backflow sealing ring (31) is installed in annular groove (30), backflow sealing ring (31) is made by elastomeric material, backflow sealing ring (31) protrudes from the medial wall of housing (11), and piston (15) top arranges annular slope (32).
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| US4312866A (en) * | 1979-07-10 | 1982-01-26 | Dr. L. Zambeletti S.P.A. | Use of rifamycin SV and its related salts in the treatment of rheumatoid arthritis, and related formulations suited for the purpose |
| CN1742718A (en) * | 2005-10-09 | 2006-03-08 | 沈阳双鼎制药有限公司 | Method for preparing rifamicina injecta |
| CN101152174A (en) * | 2007-09-11 | 2008-04-02 | 沈阳药科大学 | Stable rifamycin sodium injection prescription and preparing method of the same |
| CN101642429A (en) * | 2008-08-06 | 2010-02-10 | 郭瑞 | Method for preparing stable rifamycin sodium injection and rifamycin sodium and sodium chloride (glucose) injection |
| CN101708155A (en) * | 2009-11-27 | 2010-05-19 | 河南辅仁怀庆堂制药有限公司 | Rifamycin sodium injection and preparation method thereof |
-
2014
- 2014-06-09 CN CN201410251658.XA patent/CN104107163B/en active Active
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4312866A (en) * | 1979-07-10 | 1982-01-26 | Dr. L. Zambeletti S.P.A. | Use of rifamycin SV and its related salts in the treatment of rheumatoid arthritis, and related formulations suited for the purpose |
| CN1742718A (en) * | 2005-10-09 | 2006-03-08 | 沈阳双鼎制药有限公司 | Method for preparing rifamicina injecta |
| CN101152174A (en) * | 2007-09-11 | 2008-04-02 | 沈阳药科大学 | Stable rifamycin sodium injection prescription and preparing method of the same |
| CN101642429A (en) * | 2008-08-06 | 2010-02-10 | 郭瑞 | Method for preparing stable rifamycin sodium injection and rifamycin sodium and sodium chloride (glucose) injection |
| CN101708155A (en) * | 2009-11-27 | 2010-05-19 | 河南辅仁怀庆堂制药有限公司 | Rifamycin sodium injection and preparation method thereof |
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| Title |
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| 薛梅妍等: "注射用利福霉素钠的处方优化及稳定性考察", 《中国新药杂志》, vol. 15, no. 4, 31 December 2006 (2006-12-31), pages 284 - 287 * |
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