CN1040984A - The preparation method of copper gluconate crystals - Google Patents
The preparation method of copper gluconate crystals Download PDFInfo
- Publication number
- CN1040984A CN1040984A CN 89105191 CN89105191A CN1040984A CN 1040984 A CN1040984 A CN 1040984A CN 89105191 CN89105191 CN 89105191 CN 89105191 A CN89105191 A CN 89105191A CN 1040984 A CN1040984 A CN 1040984A
- Authority
- CN
- China
- Prior art keywords
- copper
- gluconic acid
- liquor
- acid copper
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical compound [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 title claims abstract description 23
- 229940108925 copper gluconate Drugs 0.000 title claims abstract description 23
- 239000013078 crystal Substances 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims description 8
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims abstract description 39
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract description 38
- 239000010949 copper Substances 0.000 claims abstract description 38
- 229910052802 copper Inorganic materials 0.000 claims abstract description 38
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims abstract description 36
- 235000012208 gluconic acid Nutrition 0.000 claims abstract description 36
- 239000000174 gluconic acid Substances 0.000 claims abstract description 36
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims abstract description 33
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 29
- 229910000906 Bronze Inorganic materials 0.000 claims abstract description 6
- 239000010974 bronze Substances 0.000 claims abstract description 6
- KUNSUQLRTQLHQQ-UHFFFAOYSA-N copper tin Chemical compound [Cu].[Sn] KUNSUQLRTQLHQQ-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229910000365 copper sulfate Inorganic materials 0.000 claims abstract description 5
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims abstract description 5
- JJLJMEJHUUYSSY-UHFFFAOYSA-L Copper hydroxide Chemical compound [OH-].[OH-].[Cu+2] JJLJMEJHUUYSSY-UHFFFAOYSA-L 0.000 claims abstract description 3
- 239000005750 Copper hydroxide Substances 0.000 claims abstract description 3
- NEEHYRZPVYRGPP-IYEMJOQQSA-L calcium gluconate Chemical compound [Ca+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O NEEHYRZPVYRGPP-IYEMJOQQSA-L 0.000 claims abstract description 3
- 229940116318 copper carbonate Drugs 0.000 claims abstract description 3
- 229910001956 copper hydroxide Inorganic materials 0.000 claims abstract description 3
- GEZOTWYUIKXWOA-UHFFFAOYSA-L copper;carbonate Chemical compound [Cu+2].[O-]C([O-])=O GEZOTWYUIKXWOA-UHFFFAOYSA-L 0.000 claims abstract description 3
- 238000000034 method Methods 0.000 claims abstract 3
- 238000006243 chemical reaction Methods 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 4
- NGWKGSCSHDHHAJ-YPFQVHCOSA-N Liquoric acid Chemical compound C1C[C@H](O)C(C)(C)C2CC[C@@]3(C)[C@]4(C)C[C@H]5O[C@@H]([C@](C6)(C)C(O)=O)C[C@@]5(C)[C@@H]6C4=CC(=O)C3[C@]21C NGWKGSCSHDHHAJ-YPFQVHCOSA-N 0.000 claims description 2
- NGWKGSCSHDHHAJ-UHFFFAOYSA-N Liquoric acid Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CC5OC(C(C6)(C)C(O)=O)CC5(C)C6C4=CC(=O)C3C21C NGWKGSCSHDHHAJ-UHFFFAOYSA-N 0.000 claims description 2
- 238000005649 metathesis reaction Methods 0.000 claims description 2
- 235000013305 food Nutrition 0.000 abstract description 2
- 150000002894 organic compounds Chemical class 0.000 abstract description 2
- 238000003672 processing method Methods 0.000 abstract description 2
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 238000009413 insulation Methods 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 238000013019 agitation Methods 0.000 description 2
- 239000011573 trace mineral Substances 0.000 description 2
- 235000013619 trace mineral Nutrition 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The present invention relates to a kind of organic compound, human body replenishes main by food and copper sulfate additive to copper now, utilize the copper gluconate crystals method also not see, the present invention utilizes calglucon and copper sulfate, or gluconic acid and copper carbonate or copper hydroxide are the gluconic acid copper liquor that raw material makes, then solution is added in ethanol or methyl alcohol or third bronze medal, handle to wait through insulation again and make out copper gluconate crystals, it is simple to have processing method, can disposablely directly from the gluconic acid copper liquor, make granular copper gluconate crystals, characteristics such as product performance are superior, and cost is low.
Description
The present invention relates to a kind of organic compound.
Copper is one of trace element of needed by human, human body is to lean on people's edible food and add copper sulfate in food-drink to the additional of copper at present, utilize the copper gluconate crystals body also not see to the human body trace element supplement is domestic, the preparation method of production particulate state copper gluconate crystals, through the international online retrieval World Patent Index, do not find close with relevant data record.
The purpose of this invention is to provide a kind of preparation method who from the gluconic acid copper liquor, makes out copper gluconate crystals.
The present invention realizes like this, at first be that calglucon and copper sulfate carry out replacement(metathesis)reaction generation gluconic acid copper liquor, or gluconic acid and copper carbonate or the mixed gluconic acid copper liquor that gets of copper hydroxide, at this moment because the solubleness of copper gluconate in water is very big, the copper gluconate solution concentration that reaction makes is not also separated out solid crystal to thickness, if in the gluconic acid copper liquor, add ethanol or other organic solvent, copper gluconate is then separated out and is dope, similar sugar sweet, or be divided into two-layerly, also be difficult for solidifying through long-time the placement.Feature of the present invention is after the gluconic acid copper liquor generates, and the gluconic acid copper liquor is splashed in the ethanol, and at this moment the concentration of gluconic acid copper liquor is 30%-50%(W/V), concentration of ethanol is 80%-100%; Or the gluconic acid copper liquor splashed in the methyl alcohol, the concentration of gluconic acid copper liquor is 30%-60%(W/V), methanol concentration is 70%-100%; Or the gluconic acid copper liquor splashed into Bing Tongzhong, the concentration of gluconic acid copper liquor is 30%-60%(W/V), the third copper liquor concentration is 70%-100%, give earlier ethanol or methyl alcohol or third bronze medal are heated to 50 ℃, under constantly stirring, add the gluconic acid copper solutions lentamente, concentration difference according to copper gluconate, the copper gluconate amount that adds is the 1/6-1/12 of ethanol or the methyl alcohol or the third bronze medal amount, and its limiting quantity is that copper gluconate is not separated out dope in ethanol or the methyl alcohol or third bronze medal.After the adding of gluconic acid copper solutions finishes, stir with keeping, and keep the liquid temperature at 50 ± 5 ℃, being incubated reaction in 40 minutes to 1.5 hours finishes, after above-mentioned reaction finishes,, filter and promptly get copper gluconate crystals through overcooling, before adding the gluconic acid copper solutions, can in ethanol or the methyl alcohol or third bronze medal, add 1% left and right sides gluconic acid copper crystal and do crystal seed.
Characteristics such as it is simple that the present invention has processing method, can once directly make granular copper gluconate crystals from the gluconic acid copper liquor, and product performance are superior, and cost is low.
Embodiment 1:
In 1 liter of beaker, add 500 milliliter of 95% ethanol, be heated to 50 ℃, under agitation splash into 50 milliliters of 40%(W/V) the gluconic acid copper solutions, under constantly stirring, keep the liquid temperature 50 ℃ 1 hour, cooled and filtered can draw.
Embodiment 2:
In 1 liter of beaker, add 500 milliliter 100% methyl alcohol, be heated to 50 ℃, under agitation splash into 200 milliliters of 40%(W/V) the gluconic acid copper solutions, under constantly stirring, keep the liquid temperature 50 ℃ 1 hour, cooled and filtered gets final product.
Claims (4)
1, the preparation method of copper gluconate crystals, it is characterized in that calglucon and copper sulfate carry out replacement(metathesis)reaction and gives birth to the gluconic acid copper liquor, or gluconic acid and copper carbonate or the mixed gluconic acid copper liquor that gets of copper hydroxide, then D/W is splashed in the ethanol, the concentration of gluconic acid copper liquor is 30%-50% (W/V), concentration of ethanol is 80%-100%, give and earlier ethanol is heated to 50 ℃, under constantly stirring, add the gluconic acid copper solutions lentamente, the copper gluconate amount that adds is the 1/6-1/12 of amount of alcohol, its limiting quantity is that copper gluconate is not separated out dope in ethanol, after the adding of gluconic acid copper solutions finishes, stir with keeping, and keep the liquid temperature at 50 ± 5 ℃, being incubated reaction in 40 minutes to 1.5 hours finishes, after above-mentioned reaction finishes,, filter and promptly get copper gluconate crystals through overcooling.
2, according to the preparation method of the described copper gluconate crystals of claim 1, it is characterized in that the gluconic acid copper liquor that will make splashes in the methyl alcohol, the concentration of gluconic acid copper liquor is 30%-60%(W/V), methanol concentration is 70%-100%, finishes making the gluconic acid copper crystal then by said process.
3, according to the preparation method of the described copper gluconate crystals of claim 1, it is characterized in that the gluconic acid copper liquor that will make splashes into Bing Tongzhong, the concentration of gluconic acid copper liquor is 30%-60%(W/V), the third copper liquor concentration is 70%-100%, finishes making out the gluconic acid copper crystal then by the described process of claim 1.
4, according to the preparation method of the described copper gluconate crystals of claim 1, it is characterized in that before adding the gluconic acid copper solutions, can in ethanol or the methyl alcohol or third bronze medal, add about 1% gluconic acid copper crystal and do crystal seed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 89105191 CN1040984A (en) | 1989-10-19 | 1989-10-19 | The preparation method of copper gluconate crystals |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 89105191 CN1040984A (en) | 1989-10-19 | 1989-10-19 | The preparation method of copper gluconate crystals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1040984A true CN1040984A (en) | 1990-04-04 |
Family
ID=4855959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 89105191 Pending CN1040984A (en) | 1989-10-19 | 1989-10-19 | The preparation method of copper gluconate crystals |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1040984A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1035673C (en) * | 1994-05-07 | 1997-08-20 | 中国人民解放军空军上海第一医院 | Magnesium gluconate for medicine use and its preparation method for oral liquor |
| EP1329441A1 (en) * | 2002-01-21 | 2003-07-23 | Domenico Terenzio | Plant nutrient compositions comprising gluconates and process of obtaining thereof |
| CN103454234A (en) * | 2013-09-14 | 2013-12-18 | 河南兴发精细化工有限公司 | Method for measuring content of sodium gluconate in sodium gluconate mother solution |
-
1989
- 1989-10-19 CN CN 89105191 patent/CN1040984A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1035673C (en) * | 1994-05-07 | 1997-08-20 | 中国人民解放军空军上海第一医院 | Magnesium gluconate for medicine use and its preparation method for oral liquor |
| EP1329441A1 (en) * | 2002-01-21 | 2003-07-23 | Domenico Terenzio | Plant nutrient compositions comprising gluconates and process of obtaining thereof |
| CN103454234A (en) * | 2013-09-14 | 2013-12-18 | 河南兴发精细化工有限公司 | Method for measuring content of sodium gluconate in sodium gluconate mother solution |
| CN103454234B (en) * | 2013-09-14 | 2015-05-13 | 河南兴发精细化工有限公司 | Method for measuring content of sodium gluconate in sodium gluconate mother solution |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101100407A (en) | Water cultivating anthurium andraeanum nutrient solution formulation | |
| CN101717325B (en) | Method for preparing eutectic xylitol | |
| CN1040984A (en) | The preparation method of copper gluconate crystals | |
| CN106674070A (en) | Method for extracting amino acid from hair | |
| CN102342368A (en) | Method for producing hemepeptide by using red blood cells of animal blood as raw materials | |
| CN101412716A (en) | Method for extracting lactoflavin | |
| CN103695568B (en) | A kind of syrup | |
| CN101715940B (en) | Xylose-arabinose syrup and method for preparing same | |
| CN105475583A (en) | Production process for syrup special for chocolate | |
| CN101823983A (en) | Preparation method of 2,3-dimethyl-2-isopropyl butyronitrile | |
| CA1333071C (en) | Process for production of solid sorbitol | |
| JP3044458B2 (en) | Natural salt from deep ocean water | |
| CN105400850A (en) | Production method for starch sugar | |
| JPS63301759A (en) | Production of instant powder food | |
| CN101475466B (en) | Preparation method of 1,1-cyclohexanediacetic acid | |
| CN1224710A (en) | Synthesis of hydrochloride of betaine | |
| CN107012181A (en) | A kind of threonine fermentation medium and threonine clean production process | |
| CN1091112A (en) | Preparation of potassium sulfate by circulating double decomposition of ammonium sulfate and potassium chloride | |
| CN112707793A (en) | Method for recycling DC sugar alcohol waste | |
| CN1270618C (en) | Sorghum candy preparation | |
| CN101185473B (en) | Method for preparing syrup used for sweety | |
| CN1324956A (en) | Prepn. of lactulose | |
| CN114451497B (en) | Composition containing ethylenediamine dihydroiodine, and preparation method and application thereof | |
| CN116284166B (en) | Method for recovering D-psicose crystals from syrup | |
| CN108383683A (en) | A method of with making xylitol by corn cob |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |