CN1035673C - Magnesium gluconate for medicine use and its preparation method for oral liquor - Google Patents
Magnesium gluconate for medicine use and its preparation method for oral liquor Download PDFInfo
- Publication number
- CN1035673C CN1035673C CN94112160A CN94112160A CN1035673C CN 1035673 C CN1035673 C CN 1035673C CN 94112160 A CN94112160 A CN 94112160A CN 94112160 A CN94112160 A CN 94112160A CN 1035673 C CN1035673 C CN 1035673C
- Authority
- CN
- China
- Prior art keywords
- menesia
- preparation
- magnesium gluconate
- medicine use
- distilled water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Abstract
The present invention provides a new method for preparing medicinal magnesium gluconate and an oral liquid thereof. The method uses gluconate-delta-lactone as initial raw materials. The present invention has the advantages of simple technology and low cost, and is particularly suitable for industrial production. The oral liquid of the present invention does not contain cane sugar, and is favorable for patients with diabetes to use.
Description
The invention belongs to field of medicine preparing technology
Magnesium gluconate for medicine use is as the supplement of oral magnesium, is the treatment of magnesium deficiency in the body and prevents basic medicine.Have tangible flaccidity effect, can alleviate coronary vasospasm, reduce vagusstoff and discharge, keep the cylinder electrolyte balance.The toxicity that suppresses the cadmium aluminium element, the metabolism of carcinogenic substance nitrate and nitrite in the energy acceleration bodies.Can activate the adenylate cyclase ferment, stop the release of allergin, prevent asthma attack.Can suppress the nerve and the vagus nerve of artery, make coronary dilation, have effects such as calcium antagonism and film be stable.
At present, glucose electrolytic oxidation (fermentation) is generally adopted in the preparation of gluconic acid metal-salt, again through the salifiable method that neutralizes.In addition, salifiable again method is also arranged by starch milk through saccharification and fermentation.
The invention discloses a kind of novel method for preparing Menesia, this method can be represented with following reaction formula:
The dextrose-delta-lactone gluconic acid
Concrete preparation method of the present invention is the distilled water that commercially available dextrose-delta-lactone is dissolved in equivalent, the magnesium oxide of gram molecular weights such as adding under agitation, continued heated and stirred 3 hours, add proper amount of active carbon then, decolorization filtering is collected filtrate decompression and is concentrated the raw product that the back spontaneous nucleation gets Menesia.With raw product distilled water recrystallization, to get highly finished product after the washing with alcohol, make the Menesia finished product after the drying, product yield 〉=85% again.
As follows by the Menesia that the inventive method makes through Shanghai Drug Control Inst.'s assay:
Proterties: white crystals
Differentiate: Menesia is positive reaction
Check: pH value ... 6.80
Moisture content ... 7.86%
Reducing substance ..0.12%
Oxide compound, vitriol, arsenic salt, heavy metal: qualified
Content: contain Menesia 101.2% by anhydride
The regulation that meets American Pharmacopeia 22 editions according to assay.
The present invention is that the method for feedstock production Menesia is simple and easy to do with the dextrose-delta-lactone, is suitable for suitability for industrialized production.So far do not see bibliographical information.In addition, because of the good water solubility of Menesia, can make preparations such as oral liquid.
Example 1, preparation Menesia
Get 1 kilogram of dextrose-delta-lactone, be dissolved in 1000 ml distilled waters, heating hydrolysis, stir magnesium oxide 130 grams of gram molecular weights such as adding down, continued ebuillition of heated 3 hours, add proper amount of active carbon then to filter, filtrate is evaporated to 800 milliliters at 50 ℃, put into crystallizer tank, decrease temperature crystalline, centrifugation gets crude product.The distilled water stirring and dissolving in dissolving vessel that again crude product is added equal volume amounts adds proper amount of active carbon and filters, and places crystallization, with alcohol flushing separate elaboration, 80 ℃ of dry Menesias 85.5 grams.
Example 2, preparation Menesia
Getting glucose-δ-lactones is starting raw material for 10 kilograms, makes 9.10 kilograms of Menesias by example 1 method.
Example 3, preparation Menesia
Getting glucose-δ-lactones is starting raw material for 30 kilograms, makes 25.8 kilograms of Menesias by example 1 method.
Claims (1)
1, a kind of method for preparing magnesium gluconate for medicine use, it is characterized in that this method is that commercially available dextrose-delta-lactone is dissolved in the equivalent distilled water, heating hydrolysis under agitation adds the magnesium oxide of equimolar amount, continuing ebuillition of heated stirred 3 hours, add proper amount of active carbon then, decolorization filtering is collected filtrate, spontaneous nucleation gets the Menesia raw product behind 50 ℃ of concentrating under reduced pressure, this raw product distilled water recrystallization with washing with alcohol, gets the highly finished product Menesia after 80 ℃ of dryings.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94112160A CN1035673C (en) | 1994-05-07 | 1994-05-07 | Magnesium gluconate for medicine use and its preparation method for oral liquor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94112160A CN1035673C (en) | 1994-05-07 | 1994-05-07 | Magnesium gluconate for medicine use and its preparation method for oral liquor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1118785A CN1118785A (en) | 1996-03-20 |
| CN1035673C true CN1035673C (en) | 1997-08-20 |
Family
ID=5035959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN94112160A Expired - Fee Related CN1035673C (en) | 1994-05-07 | 1994-05-07 | Magnesium gluconate for medicine use and its preparation method for oral liquor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1035673C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103372022A (en) * | 2012-04-28 | 2013-10-30 | 徐连秀 | Glucose health-care oral solution and preparation method |
| CN105621460A (en) * | 2015-12-31 | 2016-06-01 | 王丰登 | Production method of anhydrous magnesium salt |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1040984A (en) * | 1989-10-19 | 1990-04-04 | 沈阳市埃默生物化学技术研究所 | The preparation method of copper gluconate crystals |
-
1994
- 1994-05-07 CN CN94112160A patent/CN1035673C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1040984A (en) * | 1989-10-19 | 1990-04-04 | 沈阳市埃默生物化学技术研究所 | The preparation method of copper gluconate crystals |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1118785A (en) | 1996-03-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101317850B (en) | Sucrose absorption inhibitor | |
| WO2018014866A1 (en) | Crystal form of dapagliflozin intermediate and preparation method therefor | |
| CN101591271A (en) | A kind of preparation method of crystal L-arginine alpha-ketoglutarate | |
| CN1035673C (en) | Magnesium gluconate for medicine use and its preparation method for oral liquor | |
| CN110452111A (en) | A kind of method for crystallising of calcium gluconate | |
| CN1198812C (en) | Process of preparing coarse vitamin C with glulconic acid | |
| CN1050356C (en) | Process for preparing sodium (or potassium) L-ascorbate | |
| JPH08291190A (en) | New process for producing picolinic acid/chromium conjugate | |
| CN1687054A (en) | Method for preparing compound of luteolin | |
| CN1184192C (en) | Process for preparing acetyl levocarnitine hydrochlorate | |
| KR20020057085A (en) | Process for preparing healthful salt containing mineral gluconate | |
| Austin et al. | The Preparation of Two New Crystalline Aldohexoses, l-Allose and l-Altrose, from l-Ribose by the Cyanohydrin Reaction1, 2, 3 | |
| CN1112418A (en) | Preparing method of calcium ascorbate | |
| CN101591257B (en) | Preparation method of crystal L-arginine L-aspartate | |
| CN113045409A (en) | Crystallization method of calcium gluconate for injection | |
| CN1271048C (en) | Ion exchange resin purifying process for synthesizing calcium taurine | |
| CN110606863A (en) | Preparation method of N-acetylneuraminic acid dihydrate | |
| DE3890316C2 (en) | ||
| CN108546236A (en) | A kind of preparation method of aspartic acid crystal | |
| CN1100726A (en) | New process for obtaining octahydro trisodium salt of fructose 1,6-diphosphate (FdPNa3H*8H2O) in crystalline form | |
| GB2485862A (en) | Preparation process of L-arginine-alpha-ketoglutarate by direct crystallisation from fermentation broth | |
| CN101671704B (en) | Method for preparing L-selenomethionine by using enzyme separation method | |
| CN101215337B (en) | Method for preparing copper isomaltum oligosaccharide | |
| Rao et al. | Tamarind seed jellose 1: Fermentative degradation | |
| DE2143720C3 (en) | Process for the production of pure DL-tryptophan |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |