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Magnesium gluconate for medicine use and its preparation method for oral liquor

Abstract

The present invention provides a new method for preparing medicinal magnesium gluconate and an oral liquid thereof. The method uses gluconate-delta-lactone as initial raw materials. The present invention has the advantages of simple technology and low cost, and is particularly suitable for industrial production. The oral liquid of the present invention does not contain cane sugar, and is favorable for patients with diabetes to use.

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CN1035673C

China

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Chinese
Inventor
李吉
范德贤
赵树杰
姜克敬
Current Assignee
Shanghai No1 Hospital Air Force Pla
Worldwide applications
1994 CN
Application CN94112160A events
1994-05-07
Application filed by Shanghai No1 Hospital Air Force Pla
1994-05-07
Priority to CN94112160A
1996-03-20
Publication of CN1118785A
1997-08-20
Application granted
1997-08-20
Publication of CN1035673C
2014-05-07
Anticipated expiration
Status
Expired - Fee Related
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Patent citations (1)
Cited by (2)
Legal events
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Priority and Related Applications
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Description

The preparation method of magnesium gluconate for medicine use
The invention belongs to field of medicine preparing technology
Magnesium gluconate for medicine use is as the supplement of oral magnesium, is the treatment of magnesium deficiency in the body and prevents basic medicine.Have tangible flaccidity effect, can alleviate coronary vasospasm, reduce vagusstoff and discharge, keep the cylinder electrolyte balance.The toxicity that suppresses the cadmium aluminium element, the metabolism of carcinogenic substance nitrate and nitrite in the energy acceleration bodies.Can activate the adenylate cyclase ferment, stop the release of allergin, prevent asthma attack.Can suppress the nerve and the vagus nerve of artery, make coronary dilation, have effects such as calcium antagonism and film be stable.
At present, glucose electrolytic oxidation (fermentation) is generally adopted in the preparation of gluconic acid metal-salt, again through the salifiable method that neutralizes.In addition, salifiable again method is also arranged by starch milk through saccharification and fermentation.
The invention discloses a kind of novel method for preparing Menesia, this method can be represented with following reaction formula:
Figure C9411216000031
The dextrose-delta-lactone gluconic acid
Concrete preparation method of the present invention is the distilled water that commercially available dextrose-delta-lactone is dissolved in equivalent, the magnesium oxide of gram molecular weights such as adding under agitation, continued heated and stirred 3 hours, add proper amount of active carbon then, decolorization filtering is collected filtrate decompression and is concentrated the raw product that the back spontaneous nucleation gets Menesia.With raw product distilled water recrystallization, to get highly finished product after the washing with alcohol, make the Menesia finished product after the drying, product yield 〉=85% again.
As follows by the Menesia that the inventive method makes through Shanghai Drug Control Inst.'s assay:
Proterties: white crystals
Differentiate: Menesia is positive reaction
Check: pH value ... 6.80
Moisture content ... 7.86%
Reducing substance ..0.12%
Oxide compound, vitriol, arsenic salt, heavy metal: qualified
Content: contain Menesia 101.2% by anhydride
The regulation that meets American Pharmacopeia 22 editions according to assay.
The present invention is that the method for feedstock production Menesia is simple and easy to do with the dextrose-delta-lactone, is suitable for suitability for industrialized production.So far do not see bibliographical information.In addition, because of the good water solubility of Menesia, can make preparations such as oral liquid.
Example 1, preparation Menesia
Get 1 kilogram of dextrose-delta-lactone, be dissolved in 1000 ml distilled waters, heating hydrolysis, stir magnesium oxide 130 grams of gram molecular weights such as adding down, continued ebuillition of heated 3 hours, add proper amount of active carbon then to filter, filtrate is evaporated to 800 milliliters at 50 ℃, put into crystallizer tank, decrease temperature crystalline, centrifugation gets crude product.The distilled water stirring and dissolving in dissolving vessel that again crude product is added equal volume amounts adds proper amount of active carbon and filters, and places crystallization, with alcohol flushing separate elaboration, 80 ℃ of dry Menesias 85.5 grams.
Example 2, preparation Menesia
Getting glucose-δ-lactones is starting raw material for 10 kilograms, makes 9.10 kilograms of Menesias by example 1 method.
Example 3, preparation Menesia
Getting glucose-δ-lactones is starting raw material for 30 kilograms, makes 25.8 kilograms of Menesias by example 1 method.

Claims (1)
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1, a kind of method for preparing magnesium gluconate for medicine use, it is characterized in that this method is that commercially available dextrose-delta-lactone is dissolved in the equivalent distilled water, heating hydrolysis under agitation adds the magnesium oxide of equimolar amount, continuing ebuillition of heated stirred 3 hours, add proper amount of active carbon then, decolorization filtering is collected filtrate, spontaneous nucleation gets the Menesia raw product behind 50 ℃ of concentrating under reduced pressure, this raw product distilled water recrystallization with washing with alcohol, gets the highly finished product Menesia after 80 ℃ of dryings.

Patent Citations (1)

Publication number Priority date Publication date Assignee Title
CN1040984A * 1989-10-19 1990-04-04 沈阳市埃默生物化学技术研究所 The preparation method of copper gluconate crystals
Family To Family Citations
* Cited by examiner, † Cited by third party

Cited By (2)

Publication number Priority date Publication date Assignee Title
Family To Family Citations
CN103372022A * 2012-04-28 2013-10-30 徐连秀 Glucose health-care oral solution and preparation method
CN105621460A * 2015-12-31 2016-06-01 王丰登 Production method of anhydrous magnesium salt
* Cited by examiner, † Cited by third party, ‡ Family to family citation

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Priority And Related Applications

Priority Applications (1)

Application Priority date Filing date Title
CN94112160A 1994-05-07 1994-05-07 Magnesium gluconate for medicine use and its preparation method for oral liquor

Applications Claiming Priority (1)

Application Filing date Title
CN94112160A 1994-05-07 Magnesium gluconate for medicine use and its preparation method for oral liquor

Legal Events

Date Code Title Description
1995-02-22 C10 Entry into substantive examination
1995-02-22 SE01 Entry into force of request for substantive examination
1996-03-20 C06 Publication
1996-03-20 PB01 Publication
1997-08-20 C14 Grant of patent or utility model
1997-08-20 GR01 Patent grant
2004-07-07 C19 Lapse of patent right due to non-payment of the annual fee
2004-07-07 CF01 Termination of patent right due to non-payment of annual fee