CN104083897B - It is a kind of that Chinese medicine is ultrasonic involves Microwave Extraction system - Google Patents
It is a kind of that Chinese medicine is ultrasonic involves Microwave Extraction system Download PDFInfo
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Abstract
The invention provides that a kind of Chinese medicine with reflux is ultrasonic involves Microwave Extraction system, comprise the second reflux, second reflux has the taper drainage hood being inserted into sample solution device inside, the large end face of taper drainage hood covers whole liquid level, and be positioned at the position of more than liquid level near sample solution device upper end, make all gas produced in microwave heating process can enter in taper drainage hood, liquid is condensed under the effect of the inwall of taper drainage hood, and be back in sample solution along taper drainage hood, reduce the air pressure above sample solution device, improve ultrasonic wave vibrating effect.
Description
Technical field
The present invention relates to that a kind of Chinese medicine is ultrasonic involves Microwave Extraction system, belong to the abstraction technique field of Chinese medicine useful component.
Background technology
Active skull cap components in plant or Chinese medicine has broad application prospects in the fields such as medicine, food, chemical industry, cosmetics, feed.In pharmaceuticals industry, in the preparation of Chinese medical concrete, liquid extract or bioactivator and food, cosmetics, feed industry, the preparation of the functional additive of plant origin all needs to adopt extraction equipment; In chemical industry and chemical analysis field, sample pre-treatments or the process such as sample preparation, chemical synthesis also may need that employing is cleared up, extraction equipment or reactor.
Ultrasonic assistant extracts and microwave radiation exaraction is extractive technique emerging in recent years.From dried material, extract target compound be roughly divided into two steps: the 1) infiltration of material, be i.e. the expansion of material and aquation; 2) Soluble target compound is by spreading, permeating the mass transport process from material to solvent.Research shows, ultrasonic wave can make plant cell wall produce hole, is conducive to the stripping of target compound in cell, can promotes mass transport process.In addition, ultrasonic wave can also reduce raw meal particle size, thus increases the contact area of material and solvent, is conducive to the extraction of target compound.Ultrasonic assistant extract have easy to operate, with low cost, extraction time is short, be easy to amplify the advantage such as production.Ultrosonic extractor conventional at present comprises sonde-type extraction element and water-bath type extraction element.The former probe sphere of action is limited, is unfavorable for amplifying producing; The ultrasonic wave vibrational energy that the latter produces just must can be passed to sample by medium and sample bottle, and this indirectly ul-trasonic irradiation mode may affect extraction efficiency.
Microwave or can be extracted material absorbing and produce amount of heat by intracellular polar water molecules, temperature in cell is made to increase rapidly, cell membrane and cell membrane can break through by the pressure that water vapor produces, and form larger mass transfer channel, thus promote the extraction of target compound.Microwave radiation exaraction has that extraction time is short, solvent load is few, extraction efficiency advantages of higher.Microwave Extraction device conventional at present comprises sealed high pressure extraction tank and open atmospheric extraction device.The former to the intensity of extractor material and sealing requirements very high, quantity of sample handling is little, poor stability, expensive, and needs longer cool time.The latter often can not regulate Extracting temperature, have impact on the optimization of extraction process, and some thermal instability target compounds may be caused when temperature is too high to degrade.
In recent years, in order to improve extraction efficiency, patent document ultrasonic wave and Microwave Extraction technology combined is of common occurrence, void effect and microwave that Chinese patent literature can make full use of ultrasonic wave vibration had both had high energy effect, can overcome again some deficiency of conventional ultrasound and Microwave Extraction technology.Chinese patent CN2748147Y, CN1651896A.CN2773664Y.CN2822737Y, CN2880211Y disclose several ultrasonic microwave extraction element, differ from one another.
But research shows, often there is following point in existing ultrasonic wave and Microwave Extraction device:
When utilizing existing above-mentioned ultrasonic microwave extraction element to extract, As time goes on, microwave heating action is constantly accumulated, liquid in sample solution device is a lot vaporized as gas, the gas of gasification is constantly accumulated in sample solution, thus the top pressure of sample solution is constantly increased, the increase of top pressure makes the ultrasonic wave vibrating effect under condition of the same race decline, and reduces the extraction efficiency of sample.
Summary of the invention
Therefore, the technical problem to be solved in the present invention is to overcome and of the prior artly ultrasonicly involves the microwave heating equipment technological deficiency that reduces of phase extraction efficiency after treatment, thus provides higher ultrasonic of a kind of efficiency to involve Microwave Extraction system.
For this reason, the invention provides that a kind of Chinese medicine with reflux is ultrasonic involves Microwave Extraction system, comprise the openable closed box of upper cover, be arranged at the sample solution device with openable entrance of described closed box inside, be fixedly installed on the microwave introduction device on described sample solution device and ultrasonic delivery device, also comprise and be arranged on inner the second reflux for making the sample solution of vaporization reflux of described closed box, described second reflux has the drainage hood of the cross section reducing being inserted into described sample solution device inside, the big opening end of described drainage hood covers whole liquid level and is positioned at the position of more than described liquid level near described sample solution device upper end, the osculum end of described drainage hood connects condenser pipe, the outer cover of described condenser pipe is connected to circulating water flow siphunculus, described circulating water flow siphunculus arranges loop head and loop exit.
Described sample solution device is the cavity of cuboid, described microwave introduction device has the even number microwave entrance be arranged on described sample solution device, and even number microwave entrance distributes with maximum distance in pairs at cornerwise two ends in the space that the sample solution of described cavity is formed.
Described microwave entrance is the opening of rectangular shape or trapezoidal shape, be positioned at two microwave entrances at the same space diagonal two ends, the minor face of one of them microwave entrance is arranged in the horizontal direction, the minor face of another microwave entrance is vertically arranged, and the described microwave entrance that the described microwave entrance that minor face is vertically arranged is arranged in the horizontal direction than minor face is closer to the seamed edge of the vertical direction of described sample solution device; The length of described microwave entrance and the ratio of width are 25/12-24/13.
Described microwave introduction device also comprises the introduction chamber of the trapezoid cross section be connected with described microwave entrance, the osculum end of described introduction chamber is connected with described microwave entrance, both junctions arrange microwave and suppress lasso, the big opening end of described microwave introduction chamber is connected with magnetron, the outer wall of described magnetron arranges cooler, described cooler comprises the mount pad that socket is arranged on described anode of magnetron, the lug boss described mount pad being arranged annular water flowing chamber and project upwards from described mount pad, described annular water flowing chamber is divided into the intake tunnel be connected with water inlet and the exhalant canal be connected with delivery port by described lug boss.
Also comprise and be arranged on inner the first reflux for making the halfway sample solution of extraction reflux of described closed box, described first reflux comprises the liquor pump for being burst out by the sample solution extracted being inserted in below sample solution liquid level, the discharge nozzle be connected with described liquor pump, be arranged on the jet in the exit of described discharge nozzle, the corresponding feeder of described jet is arranged, described jet to be communicated with discharge nozzle by switch valve or to disconnect, also comprise return duct, one end of described return duct is inserted in described sample solution device, the other end to be communicated with discharge nozzle by check valve or to disconnect.
The ultrasonic of Chinese medicine provided by the invention involves Microwave Extraction system, also comprise and be arranged on below the whole liquid level of described sample solution device and the disk-shaped tube for stirring sample solution be communicated with described discharge nozzle by tube connector, described disk-shaped tube is arranged several bellmouths, the osculum end of described bellmouth is arranged towards liquid level; One end that described tube connector is connected with described discharge nozzle is positioned at the inside of described sample solution device.
Also comprise and be arranged on inner the second reflux for making the sample solution of vaporization reflux of described closed box, described second reflux has the taper drainage hood being inserted into described sample solution device inside, the big opening end of described taper drainage hood covers whole liquid level and is positioned at the position of more than described liquid level near described sample solution device upper end, the osculum end of described taper drainage hood connects condenser pipe, the outer cover of described condenser pipe is connected to circulating water flow siphunculus, and described circulating water flow siphunculus arranges loop head and loop exit.
Also comprise the cooling back installation be arranged between sample solution device and described closed box, the cooling liquid outlet of cooling back installation is communicated with described loop head, described cooling liquid inlet is communicated with loop exit, described cooling back installation comprises the stainless steel paster of fitting and being arranged on described sample solution device outer wall, and several deflectors highly differed be vertically set on described stainless steel paster, deflector described in several forms corrugated fluid passage, height along the described deflector of fluid direction of advance reduces gradually, gap between adjacent baffle increases gradually, gap between the adjacent baffle of fluid direction of advance forefront is not more than the 0.5-0.8 in gap between the adjacent baffle of fluid direction of advance rearmost doubly.
Also comprise coordinated regulation device, described coordinated regulation device makes described microwave introduction device to the microwave importing direction in sample solution device and described ultrasonic delivery device to the ultrasonic delivery direction orthogonal vertical all the time in described sample solution device by controlling described microwave introduction device and the position of described ultrasonic delivery device on described sample solution device, and, described coordinated regulation device arranges the first warning device, Secondary Report alarm device and the 3rd warning device, when extracting beginning, described corrdinated adjustment device controls described microwave introduction device and imports microwave, after certain hour, described first warning device sends alarm signal to described coordinated regulation device, described coordinated regulation device controls described ultrasonic delivery device and imports ultrasonic wave, after certain hour, described Secondary Report alarm device sends alarm signal to described coordinated regulation device, and described coordinated regulation device controls described microwave introduction device and ultrasonic delivery device changes its operate power, makes operate power respectively lower than its initial power, described 3rd warning device sends alarm signal to described coordinated regulation device after described microwave introduction device and described ultrasonic delivery device are with the operate power work certain hour after changing, described coordinated regulation device first controls described microwave introduction device and quits work, and the described ultrasonic delivery device of rear control quits work.
Utilize that the Chinese medicine described in above-mentioned any one is ultrasonic involves the extraction process that Microwave Extraction system carries out Chinese medicine, comprise the following steps of carrying out successively:
Step 1: the described upper cover opening closed box, and the described entrance of sample solution device, be positioned over the solution of pre-configured sample to be extracted in described sample solution device, and close described entrance and described upper cover;
Step 2: open described coordinated regulation device, described coordinated regulation device controls described microwave introduction device and opens, described microwave introduction device also imports continuous microwave in described sample solution device, the initial power of described microwave introduction device is P1, after certain hour t1, first warning device of described coordinated regulation device sends alarm signal to described coordinated regulation device, described coordinated regulation device controls described ultrasonic delivery device and opens after receiving described alarm signal, and ultrasonic wave is imported in described sample solution device, the initial power of described ultrasonic delivery device is P2, the importing direction orthogonal vertical all the time of described hyperacoustic importing direction and described microwave, after certain hour t2, the Secondary Report alarm device of described coordinated regulation device sends alarm signal to described coordinated regulation device, described coordinated regulation device after receiving described alarm signal, control described ultrasonic delivery device simultaneously and described microwave introduction device reduces power, both power is made to be less than its initial power P1 respectively, P2, described coordinated regulation device controls described ultrasonic delivery device and described microwave introduction device is out of service first to control described microwave introduction device after the Power operation certain hour t3 after reduction, rear control described ultrasonic delivery device is out of service.
Sample solution in described step 1 is the sample solution of Reishi sporule, and time t1 is 1-3 minute, and time t2 is 3-5 minute, and time t3 is 6-7 minute.
Technique scheme of the present invention has the following advantages compared to existing technology:
1. Chinese medicine provided by the invention is ultrasonic involves Microwave Extraction system, comprise and be arranged on inner the second reflux for making the sample solution of vaporization reflux of described closed box, described second reflux has the taper drainage hood being inserted into described sample solution device inside, the big opening end of described taper drainage hood covers whole liquid level and is positioned at the position of more than described liquid level near described sample solution device upper end, the large end face of taper drainage hood covers whole liquid level, and be positioned at the position of more than described liquid level near described sample solution device upper end, make all gas produced in microwave heating process can enter in described taper drainage hood, liquid is condensed under the effect of the inwall of taper drainage hood, and be back in sample solution along taper drainage hood, reduce the air pressure above sample solution device, improve ultrasonic wave vibrating effect, the osculum end of described taper drainage hood connects condenser pipe, the outer cover of described condenser pipe is connected to circulating water flow siphunculus, the portion gas of condensation cannot be carried out by the inwall of taper drainage hood, enter in condenser pipe by a bite end of taper drainage hood, by the cooling effect of circulating water flow siphunculus for condenser pipe, this portion gas is condensed in condenser pipe, is back in sample solution.
2. Chinese medicine provided by the invention is ultrasonic involves Microwave Extraction system, by arranging coordinated regulation device, to the importing time of ultrasonic wave and microwave, importing order, importing power and shut-in time strictly control, first control to import microwave, and just start to import ultrasonic wave after microwave imports certain hour, this makes the heat of microwave can pass to sample solution better, thus guarantee after sample solution is heated to certain hour and degree by microwave, just carry out hyperacoustic importing, avoid and import ultrasonic wave in advance and sample is not caused the waste of energy during heating, sample solution is heated to a certain degree, the heat effect of hyperacoustic cavitation and microwave better merges, and, it is vertical with the importing direction of microwave that coordinated regulation device controls described hyperacoustic importing direction, ultrasonic wave is made to carry out scissoring vibration to sample, vibration shell-broken effect for sample is best, and ultrasonic wave is vertical with microwave, increase hyperacoustic scissoring vibration field intensity, expand hyperacoustic vibration area, have add strong vibration and make to vibrate evenly technique effect, thus can extraction efficiency be improved, because ultrasonic delivery device and microwave introduction device are adjustable, when the height of sample solution is changed, described ultrasonic delivery device and the position of microwave introduction device on described sample solution device can be adjusted, thus make described ultrasonic wave can remain vertical with the importing direction of microwave, make the scope of application of native system larger, in addition, due to the later stage in vibration, sample is probably all by broken wall treatment, the power controlling ultrasonic delivery device and microwave introduction device is less than initial power, enter under can avoiding active material that mass transfer has gone out from the cell membrane of broken wall strong effect of vibration again in damaged cell membrane, improve the extracted amount extracting the later stage, further, the heat effect extracting later stage microwave is not obvious for the effect of extracting, and controls microwave introduction device first out of service, can reduce energy consumption further by coordinated regulation device.
3. Chinese medicine provided by the invention is ultrasonic involves Microwave Extraction system, described sample solution device is the cavity of cuboid, described microwave introduction device has the even number microwave entrance be arranged on described sample solution device, and even number microwave entrance distributes with maximum distance in pairs at cornerwise two ends in the space that the sample solution of described cavity is formed.The mode that microwave entrance adopts even number to design in pairs, and the distribution that cornerwise two ends in the space that microwave entrance is formed in cavity along sample solution are paired, after this makes ultrasonic delivery, the microwave imported from two microwave entrances is crossing with ultrasonic wave respectively, and intersection point is positioned at conplane two opposite ends, after microwave is crossing with ultrasonic wave, hyperacoustic scissoring vibration effect is enhanced respectively at conplane two ends, and enhanced diffustion effect is transmitted mutually along this plane, enhance the vibration shell-broken effect of ultrasonic wave in whole space.
4. Chinese medicine provided by the invention is ultrasonic involves Microwave Extraction system, described microwave entrance is the opening of rectangular shape or trapezoidal shape, be positioned at two microwave entrances at the same space diagonal two ends, the minor face of one of them microwave entrance is arranged in the horizontal direction, the minor face of another microwave entrance is vertically arranged, and the described microwave entrance that the described microwave entrance that minor face is vertically arranged is arranged in the horizontal direction than minor face is closer to the seamed edge of the vertical direction of described sample solution device; The length of described microwave entrance and the ratio of width are 25/12-24/13.The present invention adopts microwave incidence angle to become 0 degree of angle with sample solution, and microwave energy is absorbed by sample solution to greatest extent.Microwave entrance described in two is pressed vertical and horizontal and is arranged, after making microwave energy penetrate cavity by waveguide, the component of the horizontal direction of leading wave field forms orthogonal superposition with the component of vertical direction in cavity, improve microwave field density, make field strength distribution more even simultaneously, sample solution is in the radiation of high-intensity microwave energy completely, improve the uniformity of heating using microwave and the intensity of heating using microwave, test proves this kind of particular design of microwave entrance, for same extraction of measuring same sample solution, when obviously reducing microwave heating time, the extraction efficiency of sample but significantly improves, described sample solution device is the cavity of cuboid, this makes microwave farthest be reflected in this device, thus the utilization rate of microwave is greatly improved, and, the field intensity of orthogonal superposition can be formed between the microwave reflected, further increase heating using microwave efficiency.
5. the ultrasonic of Chinese medicine provided by the invention involves Microwave Extraction system, described microwave introduction device also comprises the introduction chamber of the trapezoid cross section be connected with described microwave entrance, described introduction chamber is waveguide cavity, the osculum end of described introduction chamber is connected with described microwave entrance, microwave is made to obtain when entering microwave entrance concentrating enhancing, both junctions arrange microwave and suppress lasso, prevent microwave in the leakage of junction, the big opening end of described microwave introduction chamber is connected with magnetron, magnetron is when producing microwave, the anode heat of magnetron constantly raises, by arranging cooler on the outer wall of described magnetron, for cooling magnetron, when the magnetron working time can be avoided larger, the burnout phenomenon caused because heat is difficult to scatter and disappear.Described cooler comprises the mount pad that socket is arranged on described anode of magnetron, the lug boss described mount pad being arranged annular water flowing chamber and project upwards from described mount pad, described annular water flowing chamber is divided into the intake tunnel be connected with water inlet and the exhalant canal be connected with delivery port by described lug boss, annular mount pad is directly socketed on described magnetron, be convenient to install, and mount pad being arranged annular water flowing chamber can make magnetron obtain omnibearing heat radiation, be more importantly, mount pad arranges lug boss, described annular water flowing chamber is divided into the intake tunnel be connected with water inlet and the exhalant canal be connected with delivery port by described lug boss, this kind of design makes the structure of cooler closely, and cooling effect is excellent.
6. the ultrasonic of Chinese medicine provided by the invention involves Microwave Extraction system, also comprise and be arranged on inner the first reflux for making the halfway sample solution of extraction reflux of described closed box, described first reflux comprises the liquor pump for being burst out by the sample solution extracted being inserted in below sample solution liquid level, the discharge nozzle be connected with described liquor pump, be arranged on the jet in the exit of described discharge nozzle, the corresponding feeder of described jet is arranged, described jet to be communicated with discharge nozzle by switch valve or to disconnect, also comprise return duct, one end of described return duct is inserted in described sample solution device, the other end to be communicated with discharge nozzle by check valve or to disconnect.After sample solution extracts, or in leaching process, need sample solution to pump when detecting, open liquor pump 2 sample solution to be pumped in described discharge nozzle, open switch valve, the coating part entered in discharge nozzle enters jet, spray into feeder so that collect and detect from described jet, now, because the pressure in described discharge nozzle is less, be less than the spring pressure of check valve, closed check valve, sample solution can not be back in sample solution device by return duct, can carry out the pumping continued; Meanwhile, another part solution entered in described discharge nozzle enters in mixing component by tube connector, and spouting from the bellmouth of mixing component, the solution of device bottom surface is dug, avoids the problem that the larger sample solution of viscosity is difficult to pumping.When not needing pumping (such as sample solution finds that sample extraction is not thorough after detecting), switch valve cuts out, now, because liquor pump continues to pumping samples solution in discharge nozzle, pressure in discharge nozzle constantly increases, when the pressure in discharge nozzle is greater than the spring pressure of check valve, the flap of described check valve is opened, check valve is opened towards the inside of sample solution device, the sample solution being positioned at discharge nozzle enters return duct along check valve, be back to sample solution device from described return duct, sample solution is made to carry out inner loop, the sample solution preventing viscosity larger produces the problem of precipitation, the vibrating effect of auxiliary ultrasonic.When finding that after retrieval sample extraction is not thorough, open the valve below feeder, feeder is communicated with sample solution device, described sample is imported again in described sample solution device, extract further, and described feeder simultaneously can as the entrance of sample solution.Above-mentioned design of the present invention, by the pan feeding of sample solution, pumping, detect, again import and prevent the effect precipitated to be combined as a whole, avoid in prior art when adopting general bottle as sample solution device, at pan feeding, all need sample bottle to take out from closed box the technological deficiency just carrying out reducing operating efficiency when discharging and detection, and be particularly useful for the extraction of the larger sample solution of viscosity, simultaneously, for the extraction of the sample solution of experimental stage, because researcher is immature for the research of experiment condition, usually there will be and extract halfway situation, this kind of design avoids takes out frequently, load the defect of sample bottle, can be understood the extraction situation of sample by pumping, reduce working strength.
7. the ultrasonic of Chinese medicine provided by the invention involves Microwave Extraction system, also comprise and be arranged on below the whole liquid level of described sample solution device and the disk-shaped tube for stirring sample solution be communicated with described discharge nozzle by tube connector, described disk-shaped tube is arranged several bellmouths, described bellmouth is bellmouth, and the osculum end of described bellmouth is arranged towards liquid level; One end that described tube connector is connected with described discharge nozzle is positioned at the inside of described sample solution device.Described liquor pump is when needs outward pumping, play the effect of pumping samples solution outward, not needing outward when pumping samples solution, the liquid level to sample solution device is sprayed by the bellmouth be arranged on disk-shaped tube, thus the sample solution generation in described sample solution device is agitated, serve the effect of stirring, effectively prevent precipitation, because described liquor pump one pump is dual-purpose, just can be stirred by the circulation of self of sample solution, do not need to introduce shaft, just can play good anti-precipitation.Described bellmouth is bellmouth, and the osculum end of described bellmouth is arranged towards liquid level.Bellmouth is set to bellmouth and osculum end is arranged towards liquid level, sample solution can be made to enter liquid level in the mode of jet, enhance stirring action, thus improves sludge proof effect.The mixing component that dish type is arranged increases stirring area, further enhancing anti-sedimentation effect.
8. the ultrasonic of Chinese medicine provided by the invention involves Microwave Extraction system, the cooling liquid outlet of cooling back installation is communicated with described loop head, described cooling liquid inlet is communicated with loop exit, namely the liquid cooled for refluxing and the cooling back installation for cooling the outer wall of sample solution device are interconnected, thus the cold of above-mentioned two cooling systems of the present invention is reused, reduce energy consumption, and, reduce the quantity of the extraneous chilled water system of native system, make structure compacter; And for the ease of the pressurization of rear circulating cooling liquid for front circulating cooling, deflector described in several forms corrugated fluid passage, height along the described deflector of fluid direction of advance reduces gradually, gap between adjacent baffle increases gradually, and the gap between the adjacent baffle of fluid direction of advance forefront is not more than the 0.5-0.8 in gap between the adjacent baffle of fluid direction of advance rearmost doubly.
Accompanying drawing explanation
In order to make content of the present invention be more likely to be clearly understood, below according to a particular embodiment of the invention and by reference to the accompanying drawings, the present invention is further detailed explanation, wherein
Fig. 1 is the ultrasonic structural representation involving Microwave Extraction system that embodiments of the invention 1 provide;
Fig. 2 is the coordinated regulation device of the extraction system that embodiments of the invention 1 provide and the electricity connection diagram of whole system;
Fig. 3 is the structural representation of the set-up mode of microwave entrance on sample solution device of the extraction system that embodiments of the invention 2 provide;
Fig. 4 is the structural representation of the cooler of the magnetron of the extraction system that embodiments of the invention 3 provide;
Fig. 5 is the first reflux of the extraction system that embodiments of the invention 4 provide and the scheme of installation of sample solution device;
Fig. 6 is the structural representation of the disk-shaped tube that embodiments of the invention 4 provide;
Fig. 7 is the structural representation of the cooling back installation of the extraction system that embodiments of the invention 5 provide.
In figure, Reference numeral is expressed as: 1-closed box, 2-sample solution device; 20-feeder; 21-liquor pump; 22-discharge nozzle; 23-jet; 24-switch valve; 25-return duct; 26-check valve; 27-tube connector; 28-disk-shaped tube; 29-bellmouth; 3-cooling-cycle device; 31-cooling liquid inlet; 32-cooling liquid outlet; 33-deflector; 5-microwave introduction device; 51-microwave entrance; 52-introduction chamber; 53-magnetron; 54-cooler; 54a-mount pad; 54b-annular water flowing chamber; 54c-lug boss; 54d-water inlet; 54e-delivery port; 54f-outer shroud; 54k-notch; 54h-passage gaps; 6-ultrasonic delivery device; 7-coordinated regulation device; 70-PLC; 71-first warning device; 72-Secondary Report alarm device; 73-the 3rd warning device; 81-taper drainage hood; 82-condenser pipe; 83-circulating water flow siphunculus; 84-loop head; 85-loop exit; 10-motor.
Detailed description of the invention
Embodiment 1
As shown in Figure 1, embodiment provides a kind of and involves Microwave Extraction system for Chinese medicine or the ultrasonic of active substance of plant extraction, comprise the openable closed box 1 of upper cover, be arranged at the sample solution device 2 with openable entrance of described closed box 1 inside, between described sample solution device 2 and described casing 1 and the sidewall of described sample solution device 2 of fitting arrange the cooling back installation 3 with cooling liquid inlet 31 and cooling liquid outlet 32, also comprise the moveable microwave introduction device 5 be arranged on described sample solution device 2, moveable ultrasonic delivery device 6 and coordinated regulation device 7, described coordinated regulation device 7 comprise PLC 70 and can with PLC 70, first warning device 71 of microwave introduction device 5 and ultrasonic delivery device 6 feedback operation, Secondary Report alarm device 72, 3rd warning device 73, at this, described first warning device 71, the signalling means with time counting function that Secondary Report alarm device 72 and the 3rd warning device 73 generally adopt for those skilled in the art.
In the present embodiment, described microwave introduction device 5 comprise produce microwave magnetron 53, for conducting the introduction chamber 52 of microwave that described magnetron 53 produces, described introduction chamber 52 is trapezoid cross section, wherein big opening end is connected with magnetron 53, osculum end is connected to microwave entrance 51, described microwave entrance 51 is arranged in the upright side walls of described sample solution device 2, this microwave entrance 51 is oblong openings, this oblong openings makes the importing direction of microwave and liquid level be zero degree angle, and sample solution is farthest heated.Described ultrasonic delivery device 6 is positioned at the bottom of described sample solution device 2, hyperacoustic importing direction is substantially vertical with the importing direction of microwave, thus make microwave heating action produce huge forward impact for hyperacoustic shearing shell-broken effect, substantially increase the destruction efficiency of ultrasonic wave for sample cell wall.
Preferred as one, the importing direction of described ultrasonic wave and described microwave is orthogonal vertical, now, microwave heating action not only can aggravate hyperacoustic shearing shell-broken effect, further, larger superposition broken wall field intensity can be produced, be convenient to promote evenly carrying out of broken wall.
In order to control described microwave introduction device 5 and the importing position of ultrasonic delivery device 6 on described sample solution device 2, the same side of described sample solution device 2 arranges several microwave entrances 51, simultaneously, this sidewall is connected with described microwave introduction device 5 by moveable baffle plate (not shown), when needs import microwave to a certain microwave entrance 51, mobile described baffle plate makes described baffle plate not block this microwave entrance 51, when needing to change the entrance importing microwave, this baffle plate mobile, baffle plate is blocked not needing the entrance importing microwave, so can realize the adjustment of baffle plate for microwave entrance 51, in the present embodiment, the movement of described baffle plate realizes electrodeless adjustment by screw.In the present embodiment, in order to realize the control of the importing position to described ultrasonic delivery device 6, the sidewall of the described ultrasonic delivery device 6 of the installation of described sample solution device 2 arranges guide-track groove (not shown), described ultrasonic delivery device 6 is provided with the sidewall matched with described guide-track groove, described sidewall is embedded described guide-track groove, the movement of described ultrasonic delivery device 6 on described sample solution device 2 can be realized by sliding, thus change the ultrasonic wave azimuth of vibration of ultrasonic delivery device 6.
In the present embodiment, in order to realize the Collaborative Control to ultrasonic delivery direction and microwave importing direction, described ultrasonic delivery device 5 and described microwave introduction device 6 arrange displacement transducer (not shown) respectively, institute's displacement sensors is connected with the PLC 70 of described coordinated regulation device 7, can transmit displacement signal and move to when receiving the action order of PLC 70 position preset to described PLC 70.
In the present embodiment, the meaning that described cooling back installation is arranged is: produce a large amount of heats after system works long hours, heat cannot shed service life of influential system, by arranging cooling back installation 3 in the gap of described sample solution device 2 and described closed box 1, not only the amount of heat produced in system works can be scattered and disappeared, cooling back installation 3 is arranged on system can be made between the two compacter, during work, cooling fluid is imported from cooling liquid inlet 31, cooling fluid makes the heat of the system liquid that is cooled take away for the conduction of cold, finally discharge from cooling liquid outlet 32, thus the heat of system (especially sample solution device 2) is dispersed, the service life of raising system.
Above-mentioned ultrasonic the involving when Microwave Extraction system carries out the active material extraction of sample utilizing the present embodiment to provide comprises following processing step:
Step 1: the described upper cover opening closed box 1, and the described entrance of sample solution device 2, be positioned over the solution of pre-configured sample to be extracted in described sample solution device 2, and close described entrance and described upper cover;
Step 2: open described coordinated regulation device 7, as shown in Figure 2, first the PLC 70 of described coordinated regulation device 7 sends signal to described microwave introduction device 5 and the first warning device 71, described microwave introduction device 5 is started working with initial power P1 immediately after receiving described signal, simultaneously, described first warning device 71 starts to carry out time counting after receiving described signal, after elapsed time t1, described first warning device 71 sends alarm signal to described PLC, described PLC 70 sends working signal to described ultrasonic delivery device 6 after receiving described alarm signal, and send working signal to described Secondary Report alarm device 72 simultaneously, described ultrasonic delivery device 71 is started working with initial power P2 immediately after receiving described working signal, described Secondary Report alarm device 72 starts to carry out time counting after receiving working signal, after elapsed time t2, described Secondary Report alarm device 72 sends signal to described PLC 70, described PLC sends to described microwave introduction device 5 and described ultrasonic delivery device 6 signal changing operating power after receiving described signal simultaneously, and send working signal to the 3rd warning device 73, described microwave introduction device 5 and described ultrasonic delivery device 6 change its operating power respectively after receiving this signal, operating power is made to be less than its initial power P1 respectively, P2, described 3rd warning device 73 starts to carry out time counting after receiving this working signal, after elapsed time t3, described 3rd warning device 73 sends signal to described PLC 70, described PLC 70 first controls described microwave introduction device 5 and quits work after receiving described signal, the described ultrasonic delivery device 6 of rear control quits work.
The said extracted system of the present embodiment, achieves the Comprehensive Control of job order to described microwave introduction device 5 and described ultrasonic delivery device 6, working time, operating power and stopping order by coordinated regulation device 7.First control to import microwave, and just start to import ultrasonic wave after microwave imports certain hour, this makes the heat of microwave can pass to sample solution better, thus guarantee after sample solution is heated to certain hour and degree by microwave, just carry out hyperacoustic importing, avoid and import ultrasonic wave in advance and sample is not caused the waste of energy during heating; Sample solution is heated to a certain degree, the heat effect of hyperacoustic cavitation and microwave better merges, and, it is vertical with the importing direction of microwave that coordinated regulation device 7 controls described hyperacoustic importing direction, ultrasonic wave is made to carry out scissoring vibration to sample, vibration shell-broken effect for sample is best, and ultrasonic wave is vertical with microwave, increase hyperacoustic scissoring vibration field intensity, expand hyperacoustic vibration area, have add strong vibration and make to vibrate evenly technique effect, thus can extraction efficiency be improved; Because ultrasonic delivery device 6 and microwave introduction device 6 are adjustable, when the height of sample solution is changed, the position on sample solution device 2 described in described ultrasonic delivery device 6 microwave introduction device 5 can be adjusted, thus make described ultrasonic wave can remain vertical with the importing direction of microwave, make the scope of application of native system larger; In addition, due to the later stage in vibration, sample is probably all by broken wall treatment, the power controlling ultrasonic delivery device and microwave introduction device is less than initial power, the active material that mass transfer has gone out from the cell membrane of broken wall can be avoided to enter in damaged cell membrane under strong effect of vibration again, improve the extracted amount extracting the later stage; Further, the heat effect extracting later stage microwave is not obvious for the effect of extracting, and controls microwave introduction device first out of service, can reduce energy consumption further by coordinated regulation device.
It should be noted that, when the said extracted system utilizing the present embodiment to provide carries out the extraction of bioactivator, described time t1, t2, t3, initial power P1, P2 and the operate power after changing can change according to the different material extracted, above-mentioned numerical value is when extraction work starts, pre-set according to the different material extracted.In the present embodiment, said extracted system is used for the extraction to Reishi sporule, wherein time t1 is 1-3 minute, time t2 is 3-5 minute, and time t3 is 2-3 minute, thus makes whole extraction time control in 6-11 minute, substantially increase extraction efficiency, initial power P1 is 50-200W, and initial power P2 is 50-100W, greatly reduces energy consumption.
Embodiment 2
The present embodiment provides a kind of and ultrasonicly involves Microwave Extraction system, it is the distortion on embodiment 1 basis, as shown in Figure 3, the extraction system that the present embodiment provides is relative to the improvement of embodiment 1: described sample solution device 2 is the cavity of cuboid, described microwave introduction device 5 has the even number microwave entrance 51 be arranged on described sample solution device 2, and even number microwave entrance 51 distributes with maximum distance in pairs at cornerwise two ends in the space that the sample solution of described cavity is formed.Two described microwave entrances 51 distribute with maximum distance in pairs at cornerwise two ends in the space that the sample solution of described cavity is formed.After this makes ultrasonic delivery, the microwave imported from two microwave entrances 51 is crossing with ultrasonic wave respectively, and intersection point is positioned at conplane two opposite ends, after microwave is crossing with ultrasonic wave, hyperacoustic scissoring vibration effect is enhanced respectively at conplane two ends, and enhanced diffustion effect is transmitted mutually along this plane, enhance the vibration shell-broken effect of ultrasonic wave in whole space.
One as the present embodiment is out of shape, described microwave entrance 51 can also be set to other numbers, such as 4,6,8 etc. even number numbers, even number microwave entrance 51 distributes along cornerwise two ends in the space that sample solution is formed in pairs with maximum distance.
Improve as one, in the present embodiment, described microwave entrance 51 is the opening of rectangular shape, be positioned at two microwave entrances 51 at the same space diagonal two ends, the minor face of one of them microwave entrance 51 is arranged in the horizontal direction, the minor face of another microwave entrance 51 is vertically arranged, and the described microwave entrance 51 that the described microwave entrance 51 that minor face is vertically arranged is arranged in the horizontal direction than minor face is closer to the seamed edge of the vertical direction of described sample solution device 2; The length of described microwave entrance 51 and the ratio of width are 25/12-24/13.Particularly, distance between the vertical edges of the vertical seamed edge that the close described microwave resonance be close to of described microwave entrance 51 that minor face is vertically arranged is strong and this vertical seamed edge is 75 millimeters, and the described microwave entrance 51 that minor face is arranged in the horizontal direction is 90 millimeters near the distance between the vertical edges and this vertical seamed edge of the vertical seamed edge of the cavity be close to.The length of described microwave entrance 51 is 250 millimeters, and width is 130 millimeters, and the inside of described cavity has sample solution, and the distance of the liquid level of described sample solution and the upper wall of described cavity is 120 millimeters.
What the present embodiment provided above-mentioned ultrasonicly involves Microwave Extraction system, and microwave incidence angle becomes 0 degree of angle with sample solution, microwave energy is absorbed by sample solution to greatest extent.Microwave entrance 51 described in two is pressed vertical and horizontal and is arranged, after making microwave energy penetrate cavity by waveguide, the component of the horizontal direction of leading wave field forms orthogonal superposition with the component of vertical direction in cavity, improve field intensity, make field strength distribution more even simultaneously, sample solution is in the radiation of high-intensity microwave energy completely, improve the uniformity of heating using microwave and the intensity of heating using microwave, test proves this kind of particular design of microwave entrance, for same extraction of measuring same sample solution, when obviously reducing microwave heating time, the extraction efficiency of sample but significantly improves, described sample solution device is the cavity of cuboid, this makes microwave farthest be reflected in this device, thus the utilization rate of microwave is greatly improved, and, the field intensity of orthogonal superposition can be formed between the microwave reflected, further increase heating using microwave efficiency.
One as the present embodiment is out of shape, and described microwave entrance 51 can also be the opening of trapezoidal shape.
Embodiment 3
The present embodiment provides a kind of and ultrasonicly involves Microwave Extraction system, it is the distortion on embodiment 1 or 2 basis, in the present embodiment, as shown in Figure 4, described microwave introduction device 5 comprises magnetron 53, excitation system, reponse system (not shown) and cooler 54.Magnetron 53 output frequency is 2450MHz, exports mean power 6kW, peak power output 10kw.Excitation system has two groups, one group of electromagnetism iron wire bag being magnetron and carrying, another group be by enamel-covered wire around the coil be enclosed within outside the electromagnetism iron wire bag of magnetron, these two parts have special field power supply, electromagnetic electric current in electromagnetism iron wire bag is about 8.0A, and in additional coil, the large I of electric current is adjusted by coordinated regulation device 7.Reponse system has two parts, and a part is input to by anode current to feed back in section coil of in magnet exciting coil, and another part designs a sampling resistor and is connected in anode of magnetron loop, provides anode current information.Described cooler 54 comprises the lug boss 54c that mount pad 54a described in mount pad 54a that socket is arranged on described magnetron 53 anode arranges annular water flowing chamber 54b and projects upwards from described mount pad 54a, and described annular water flowing chamber 54b is divided into the intake tunnel be connected with water inlet 54d and the exhalant canal be connected with delivery port 54e by described lug boss 54c.The concrete size of cooler 54 is pressed the size of magnetron 53 and determines.
In the present embodiment, described cooler 54 is adopt extruded integral piece, thus makes described cooler 54 sealing best.The outer wall of described annular water flowing chamber 54b arranges outer shroud 54f, described outer shroud 54f for installing refrigerating gas, for dispelling the heat to the liquid in annular water flowing chamber 54b.
Lug boss 54c is as the watershed of annular water flowing chamber 54b in the present embodiment, in order to the shunting of turnover current, makes annular water flowing chamber 54b become circulation runner.Lug boss 54c is corresponding with annular water flowing chamber 54b goes out to form passage gaps 54h, and its effect makes whole circumference in annular water flowing chamber 54b have water to flow through to derive heat, and magnetron 53 anode perisporium is dispelled the heat evenly.The endoporus of cooler 54 and the external diameter interference fit of anode of magnetron.In the present embodiment, the lateral margin of described mount pad 54a arranges U-lag mouth, beat groove in order to fixing spiral shell for subsequent use when its effect is and installs for cooler, make it that rear magnetron is installed and be fixed in framework.
Embodiment 4
The present embodiment provides a kind of and ultrasonicly involves Microwave Extraction system, it is the distortion on embodiment 1 or 2 or 3 basis, in the present embodiment, as shown in Figure 5, described extraction system also comprises the first reflux being arranged on described closed box 1 inside and refluxing for making the halfway sample solution of extraction, described first reflux comprises the liquor pump 21 for being burst out by the sample solution extracted being inserted in below sample solution liquid level, for driving the motor 10 of liquor pump 21, the discharge nozzle 22 be connected with described liquor pump 21, be arranged on the jet 23 in the exit of described discharge nozzle 22, the corresponding feeder 20 of described jet 23 is arranged, the lower end of described feeder 20 to be communicated with sample solution device 2 by valve or to disconnect, described jet 23 to be communicated with discharge nozzle 22 by switch valve 24 or to disconnect, also comprise return duct 25, one end of described return duct 25 is inserted in described sample solution device 2, the other end to be communicated with discharge nozzle 22 by check valve 26 or to disconnect.Also comprise and be arranged on below the whole liquid level of described sample solution device 2 and the disk-shaped tube 28 for stirring sample solution be communicated with described discharge nozzle 22 by tube connector 27, described disk-shaped tube 28 is arranged several bellmouths 29, the osculum end of described bellmouth is arranged towards liquid level; One end that described tube connector 27 is connected with described discharge nozzle 22 is positioned at the inside of described sample solution device 2.
It should be noted that, check valve 26 in the present embodiment is check valves of a kind of spring, its basic operation principle is, when switch valve 24 is opened, the pressure of spring is greater than the pressure in described discharge nozzle 22, and the flap of check valve 26 is closed, and the sample solution in discharge nozzle 22 can not enter in described return duct 25, now, the normal pumping of sample solution is carried out; When not needing pumping samples solution, switch valve 24 cuts out, pressure in discharge nozzle 22 increases gradually, when the pressure in discharge nozzle 22 is greater than spring pressure, the flap of check valve 26 is backed down, thus check valve is opened towards the inside of described sample solution device 2, now, the liquid of discharge nozzle 22 enters in described return duct 25 along check valve 26, and is back in described sample solution device 2.
It should be noted that, the check valve mentioned in the present embodiment its object be set mainly be release, and can to open when described switch valve 24 cuts out, the sample in discharge nozzle 22 entered in return duct 25 and is back in sample solution device 2; And when described switch valve 24 is opened, described check valve 26 is closed, sample solution in discharge nozzle 22 is injected into feeder 20 from described jet 23, in feeder 20, sample solution is collected or is detected, if find after sensing, sample solution does not extract completely, then open the valve between feeder 20 and sample solution device 2, make sample solution come back in sample solution device.For realizing this main purpose, specifically arranging of described check valve can be various, except the spring check valve that the present embodiment is mentioned, and can be set to gravity-held check valve, swing type check valve etc.
The above-mentioned design of the present embodiment, by the pan feeding of sample solution, pumping, detect, again import and prevent the effect precipitated to be combined as a whole, avoid in prior art when adopting general bottle as sample solution device, at pan feeding, all need sample bottle to take out from closed box the technological deficiency just carrying out reducing operating efficiency when discharging and detection, and be particularly useful for the extraction of the larger sample solution of viscosity, simultaneously, for the extraction of the sample solution of experimental stage, because researcher is immature for the research of experiment condition, usually there will be and extract halfway situation, this kind of design avoids takes out frequently, load the defect of sample bottle, can be understood the extraction situation of sample by pumping, reduce working strength.
Embodiment 5
The present embodiment provides a kind of and ultrasonicly involves Microwave Extraction system, it is the distortion on embodiment 1 or 2 or 3 or 4 basis, in the present embodiment, the cooling liquid outlet 32 of described cooling back installation 3 is communicated with described loop head 84, described cooling liquid inlet 31 is communicated with loop exit 85, described cooling back installation 3 comprises the stainless steel paster of fitting and being arranged on described sample solution device 2 outer wall, and several deflectors 33 be vertically set on described stainless steel paster, described in several, deflector 33 forms corrugated fluid passage, as shown in Figure 7, along fluid direction of advance, gap between adjacent baffle 33 increases gradually, gap between the adjacent baffle 33 of fluid direction of advance forefront is not more than the 0.5-0.8 in gap between the adjacent baffle 23 of fluid direction of advance rearmost doubly.
As further improvement of this embodiment, the height of several deflectors 33 can be set to highly differ, and the height being positioned at the described deflector 33 of the same side reduces gradually along the flow direction of fluid.
Embodiment 6
The present embodiment provides a kind of and ultrasonicly involves Microwave Extraction system, it is the further improvement on embodiment 1 or 2 or 3 or 4 or 5 basis, in the present embodiment, as shown in Figure 1, also comprise the second reflux being arranged on described closed box 1 inside and refluxing for making the sample solution of vaporization, described second reflux has the taper drainage hood 81 being inserted into described sample solution device inside, the big opening end of described taper drainage hood 81 covers whole liquid level and is positioned at the position of more than described liquid level near described sample solution device 2 upper end, the osculum end of described taper drainage hood 81 connects condenser pipe 82, the outer cover of described condenser pipe 82 is connected to circulating water flow siphunculus 83, described circulating water flow siphunculus 83 is arranged loop head 84 and loop exit 85.
Obviously, above-described embodiment is only for clearly example being described, and the restriction not to embodiment.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here exhaustive without the need to also giving all embodiments.And thus the apparent change of extending out or variation be still among the protection domain of the invention.
Claims (6)
1. a Chinese medicine is ultrasonic involves Microwave Extraction system, comprise the openable closed box of upper cover (1), be arranged at the sample solution device (2) with openable entrance that described closed box (1) is inner, be arranged on fixing microwave introduction device (5) and the ultrasonic delivery device (6) of described sample solution device (2), it is characterized in that: also comprise and be arranged on inner the second reflux for making the sample solution of vaporization reflux of described closed box (1), described second reflux has the drainage hood (81) with reducing cross section being inserted into described sample solution device inside, the big opening end of described drainage hood (81) covers whole liquid level and is positioned at the position of more than described liquid level near described sample solution device (2) upper end, the osculum end of described drainage hood (81) connects condenser pipe (82), the outer cover of described condenser pipe (82) is connected to circulating water flow siphunculus (83), described circulating water flow siphunculus (83) is arranged loop head (84) and loop exit (85), also comprise and be arranged on inner the first reflux for making the halfway sample solution of extraction reflux of described closed box (1), described first reflux comprises the liquor pump (21) for being burst out by the sample solution extracted being inserted in below sample solution liquid level, the discharge nozzle (22) be connected with described liquor pump (21), be arranged on the jet (23) in the exit of described discharge nozzle (22), described jet (23) corresponding feeder (20) is arranged, the lower end of described feeder (20) to be communicated with sample solution device (2) by valve or to disconnect, described jet (23) to be communicated with discharge nozzle (22) by switch valve (24) or to disconnect, also comprise return duct (25), one end of described return duct (25) is inserted in described sample solution device (2), the other end is communicated with discharge nozzle (22) by check valve (26) or is disconnected.
2. Chinese medicine according to claim 1 is ultrasonic involves Microwave Extraction system, it is characterized in that: also comprise and be arranged on below the whole liquid level of described sample solution device (2) and the disk-shaped tube (28) be communicated with described discharge nozzle (22) by tube connector (27), described disk-shaped tube (28) is arranged several bellmouths (29), the osculum end of described bellmouth (29) is arranged towards liquid level; One end that described tube connector (27) is connected with described discharge nozzle (22) is positioned at the inside of described sample solution device (2).
3. Chinese medicine according to claim 1 and 2 is ultrasonic involves Microwave Extraction system, it is characterized in that: also comprise coordinated regulation device (7), described coordinated regulation device (7) is by controlling described microwave introduction device (5) and the position of described ultrasonic delivery device (6) on described sample solution device (2) makes described microwave introduction device (5) to the microwave importing direction in sample solution device (2) and described ultrasonic delivery device (6) to the ultrasonic delivery direction orthogonal vertical all the time in described sample solution device (2), and, described coordinated regulation device (7) arranges the first warning device, Secondary Report alarm device and the 3rd warning device, when extracting beginning, described corrdinated adjustment device (7) controls described microwave introduction device (5) and imports microwave, after certain hour, described first warning device sends alarm signal to described coordinated regulation device (7), described coordinated regulation device (7) controls described ultrasonic delivery device (6) and imports ultrasonic wave, after certain hour, described Secondary Report alarm device sends alarm signal to described coordinated regulation device, described coordinated regulation device (7) controls described microwave introduction device (5) and ultrasonic delivery device (6) changes its operate power, makes operate power respectively lower than its initial power, described 3rd warning device sends alarm signal at described microwave introduction device (5) and described ultrasonic delivery device (6) with the backward described coordinated regulation device (7) of operate power work certain hour after changing, described coordinated regulation device (7) first controls described microwave introduction device (5) and quits work, and the described ultrasonic delivery device (6) of rear control quits work.
4. Chinese medicine according to claim 3 is ultrasonic involves Microwave Extraction system, it is characterized in that: the cavity that described sample solution device (2) is cuboid, described microwave introduction device (5) has the even number microwave entrance (51) be arranged on described sample solution device (2), and even number microwave entrance (51) distributes with maximum distance in pairs at cornerwise two ends in the space that the sample solution of described cavity is formed.
5. Chinese medicine according to claim 4 is ultrasonic involves Microwave Extraction system, it is characterized in that: the opening that described microwave entrance (51) is rectangular shape or trapezoidal shape, be positioned at two microwave entrances (51) at the same space diagonal two ends, the minor face of one of them microwave entrance (51) is arranged in the horizontal direction, the minor face of another microwave entrance (51) is vertically arranged, the described microwave entrance (51) that the described microwave entrance (51) that minor face is vertically arranged is arranged in the horizontal direction than minor face is closer to the seamed edge of the vertical direction of described sample solution device (2), the length of described microwave entrance (51) and the ratio of width are 25/12-24/13.
6. Chinese medicine according to claim 5 is ultrasonic involves Microwave Extraction system, it is characterized in that: described microwave introduction device (5) also comprises the introduction chamber (52) of the trapezoid cross section be connected with described microwave entrance (51), the osculum end of described introduction chamber (52) is connected with described microwave entrance (51), both junctions arrange microwave and suppress lasso, the big opening end of described microwave introduction chamber is connected with magnetron (53), the outer wall of described magnetron (53) is arranged cooler (54), described cooler (54) comprises the mount pad (54a) that socket is arranged on described magnetron (53) anode, the lug boss (54c) described mount pad (54a) being arranged annular water flowing chamber (54b) and project upwards from described mount pad (54a), described annular water flowing chamber (54b) is divided into the intake tunnel be connected with water inlet (54d) and the exhalant canal be connected with delivery port (54e) by described lug boss (54c).
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| CN108970777A (en) * | 2018-09-05 | 2018-12-11 | 湖南仟鹤康生物科技有限公司 | A kind of vacuum ultrasonic wall-breaking machine |
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| GB2056292A (en) * | 1978-11-06 | 1981-03-18 | Fuji Photo Film Co Ltd | Method and apparatus for dissolving entrained bubbles in a liquid |
| DE10003243A1 (en) * | 2000-01-26 | 2001-08-02 | Inst Nichtklassische Chemie E | Rapid yet controlled and gentle extraction of materials from diverse matrices by use of supercritical fluids, employs microwave heating |
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Effective date of registration: 20160115 Address after: Yueqing City, Zhejiang province Yuecheng town Tadatoki outside No. 6 Lane 2 Applicant after: Jin Feng Address before: 215011 Jiangsu city of Suzhou province high tech Zone of Shishan Xinyuan street or building 45 102 Applicant before: Lin Xueqin |
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Inventor after: Fang Xiaoyan Inventor before: Jin Feng |
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Effective date of registration: 20170831 Address after: 437300, No. 44 Bridge Road, Chibi, Hubei, Xianning, Puqi Patentee after: Fang Xiaoyan Address before: Yueqing City, Zhejiang province Yuecheng town Tadatoki outside No. 6 Lane 2 Patentee before: Jin Feng |
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Effective date of registration: 20180328 Address after: 510000 Guangdong Province, Guangzhou high tech Industrial Development Zone, No. 233 science road 231 floor B1B2 building one layer, two layer, three layer, four layer Patentee after: BOAO ZONGHENG NETWORK TECHNOLOGY Co.,Ltd. Address before: 437300, No. 44 Bridge Road, Chibi, Hubei, Xianning, Puqi Patentee before: Fang Xiaoyan Effective date of registration: 20180328 Address after: 518000 Shenzhen City, Shenzhen City, Guangdong, Nanshan District Nanshan street, Zhongxing Industrial City, 6 4 Building 425 Patentee after: SHENZHEN YUMEI HIGH STANDARD ELECTRONICS CO.,LTD. Address before: 510000 Guangdong Province, Guangzhou high tech Industrial Development Zone, No. 233 science road 231 floor B1B2 building one layer, two layer, three layer, four layer Patentee before: BOAO ZONGHENG NETWORK TECHNOLOGY Co.,Ltd. |
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Address after: 518000 10K, Nanyuan maple leaf building, No. 1088, Nanshan Avenue, Dengliang community, Nanshan street, Nanshan District, Shenzhen, Guangdong Province Patentee after: Shenzhen Yumei Gaobiao Technology Co.,Ltd. Address before: 518000 room 425, 4th floor, building 6, Zhongxing Industrial City, Chuangye Road, Nanshan street, Nanshan District, Shenzhen City, Guangdong Province Patentee before: SHENZHEN YUMEI HIGH STANDARD ELECTRONICS CO.,LTD. |