CN104083445B - One treats leukodermic external application Chinese medicine - Google Patents
One treats leukodermic external application Chinese medicine Download PDFInfo
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- CN104083445B CN104083445B CN201410385825.XA CN201410385825A CN104083445B CN 104083445 B CN104083445 B CN 104083445B CN 201410385825 A CN201410385825 A CN 201410385825A CN 104083445 B CN104083445 B CN 104083445B
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- 239000003814 drug Substances 0.000 title claims abstract description 41
- 229940079593 drug Drugs 0.000 claims abstract description 12
- 241001074093 Echinopsis Species 0.000 claims abstract description 9
- 238000011282 treatment Methods 0.000 claims description 34
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 10
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 206010025421 Macule Diseases 0.000 description 10
- 230000000052 comparative effect Effects 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 206010047642 Vitiligo Diseases 0.000 description 5
- 235000008216 herbs Nutrition 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 230000035614 depigmentation Effects 0.000 description 2
- 230000008034 disappearance Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- ZCCUUQDIBDJBTK-UHFFFAOYSA-N psoralen Chemical compound C1=C2OC(=O)C=CC2=CC2=C1OC=C2 ZCCUUQDIBDJBTK-UHFFFAOYSA-N 0.000 description 2
- 206010040882 skin lesion Diseases 0.000 description 2
- 231100000444 skin lesion Toxicity 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- VXGRJERITKFWPL-UHFFFAOYSA-N 4',5'-Dihydropsoralen Natural products C1=C2OC(=O)C=CC2=CC2=C1OCC2 VXGRJERITKFWPL-UHFFFAOYSA-N 0.000 description 1
- 206010048768 Dermatosis Diseases 0.000 description 1
- 241001313288 Labia Species 0.000 description 1
- 241001597008 Nomeidae Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 210000003953 foreskin Anatomy 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 210000003899 penis Anatomy 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000036561 sun exposure Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The invention discloses one and treat leukodermic external application Chinese medicine, be made up of the Chinese crude drug of following weight portion: Herba pterocephali 60 ~ 100 parts, Radix Berberidis 30 ~ 50 parts, Folium Microcoris paniculatae 1 ~ 15 part, Folium Sauropi 1 ~ 15, Pterospermi Heterophylli 1 ~ 15, Radix Sambuci Chiensis 1 ~ 5 part, Cortex Syingae Amurensis 1 ~ 5 part, Herba Hyperici Japonici 1 ~ 5 part, Radix Et Caulis Acanthopanacis Senticosi 1 ~ 5 part, Folium Elaeagni 1 ~ 5 part, Radix Boehmeriae 1 ~ 5 part, Radix Tinosporae 1 ~ 5 part, Radix Echinopsis 1 ~ 3 part, Rhizoma Panacis Japonici 1 ~ 3 part.The present invention compared to the beneficial effect of prior art is: good effect, short treating period, side effect is little, relapse rate is low.
Description
Technical field
The present invention relates to technical field of Chinese medicines, specifically refer to that one treats leukodermic external application Chinese medicine.
Background technology
Vitiligo is a kind of because of skin limitation depigmentation, Metabolic disorder and the white macula that occurs, and do not ache and do not itch, multiple face and other place easily exposed be born in, the traditional Chinese medical science is called " vitiligo ", because autoimmune function is low, qi-blood disharmony, caused by diseases caused by exogenous pathogenic factor ailment said due to cold or exposure.Vitiligo belongs to obstinate disease, and patient can not be restored, very painful.
In current existing technology, doctor trained in Western medicine is without specific treatment method, general by oral or topical application light sensation medicine, psoralen and derivant thereof, can be generated by stimulation melanin by ultraviolet or sun exposure.This therapy causes very large misery and financial burden to patient, and therapeutic effect is not good.Treat leukodermic Chinese medicine a lot, but Chinese medicine widespread treatments course for the treatment of long, take effect slow, effect is not remarkable.
Summary of the invention
In order to make up the deficiencies in the prior art, the invention provides a kind of good effect, short treating period, side effect is little, relapse rate the is low leukodermic external application Chinese medicine for the treatment of.Realize particular by following technical scheme:
One treats leukodermic external application Chinese medicine, is made up of the Chinese crude drug of following weight portion: Herba pterocephali 60 ~ 100 parts, Radix Berberidis 30 ~ 50 parts, Folium Microcoris paniculatae 1 ~ 15 part, Folium Sauropi 1 ~ 15 part, Pterospermi Heterophylli 1 ~ 15 part, Radix Sambuci Chiensis 1 ~ 5 part, Cortex Syingae Amurensis 1 ~ 5 part, Herba Hyperici Japonici 1 ~ 5 part, Radix Et Caulis Acanthopanacis Senticosi 1 ~ 5 part, Folium Elaeagni 1 ~ 5 part, Radix Boehmeriae 1 ~ 5 part, Radix Tinosporae 1 ~ 5 part, Radix Echinopsis 1 ~ 3 part, Rhizoma Panacis Japonici 1 ~ 3 part.
Preferably, one treats leukodermic external application Chinese medicine, is made up of the Chinese crude drug of following weight portion: Herba pterocephali 80 parts, Radix Berberidis 40 parts, Folium Microcoris paniculatae 8 parts, Folium Sauropi 8 parts, Pterospermi Heterophylli 8 parts, Radix Sambuci Chiensis 3 parts, Cortex Syingae Amurensis 3 parts, Herba Hyperici Japonici 3 parts, Radix Et Caulis Acanthopanacis Senticosi 3 parts, Folium Elaeagni 3 parts, Radix Boehmeriae 3 parts, Radix Tinosporae 3 parts, Radix Echinopsis 2 parts, Rhizoma Panacis Japonici 2 parts.
The preparation method of the leukodermic external application Chinese medicine of above-mentioned treatment is: the Chinese crude drug taking described weight portion puts into frying pan, stir-fries 20 minutes with slow fire heating; Then put into drug-decocting appliance, add the pure water of 1500 weight portions, boil rear slow fire with high heat and decoct 30 minutes, cooled and filtered removing medicinal residues, gained medicinal liquid is the leukodermic external application Chinese medicine for the treatment of.
Therapeutic Method: Chinese medicine of the present invention is applied to affected part, every day is early, middle and late respectively once, within 1 month, is 1 course for the treatment of.
The invention provides one and treat leukodermic external application Chinese medicine, compared to the beneficial effect of prior art be: good effect, short treating period, side effect is little, relapse rate is low.
Detailed description of the invention:
Below in conjunction with embodiment, the present invention is further illustrated.
Embodiment 1:
Take Herba pterocephali 60g, Radix Berberidis 50g, Folium Microcoris paniculatae 1g, Folium Sauropi 15g, Pterospermi Heterophylli 1g, Radix Sambuci Chiensis 5g, Cortex Syingae Amurensis 1g, Herba Hyperici Japonici 5g, Radix Et Caulis Acanthopanacis Senticosi 1g, Folium Elaeagni 5g, Radix Boehmeriae 1g, Radix Tinosporae 5g, Radix Echinopsis 1g, Rhizoma Panacis Japonici 3g put into frying pan, stir-fry 20 minutes with slow fire heating; Then put into drug-decocting appliance, add the pure water of 1500g, boil rear slow fire with high heat and decoct 30 minutes, cooled and filtered removing medicinal residues, gained medicinal liquid is the leukodermic external application Chinese medicine for the treatment of.
Embodiment 2:
Take Herba pterocephali 100g, Radix Berberidis 30g, Folium Microcoris paniculatae 15g, Folium Sauropi 1g, Pterospermi Heterophylli 15g, Radix Sambuci Chiensis 1g, Cortex Syingae Amurensis 5g, Herba Hyperici Japonici 1g, Radix Et Caulis Acanthopanacis Senticosi 5g, Folium Elaeagni 1g, Radix Boehmeriae 5g, Radix Tinosporae 1g, Radix Echinopsis 3g, Rhizoma Panacis Japonici 1g put into frying pan, stir-fry 20 minutes with slow fire heating; Then put into drug-decocting appliance, add the pure water of 1500g, boil rear slow fire with high heat and decoct 30 minutes, cooled and filtered removing medicinal residues, gained medicinal liquid is the leukodermic external application Chinese medicine for the treatment of.
Embodiment 3:
Take Herba pterocephali 80g, Radix Berberidis 40g, Folium Microcoris paniculatae 8g, Folium Sauropi 8g, Pterospermi Heterophylli 8g, Radix Sambuci Chiensis 3 parts, Cortex Syingae Amurensis 3g, Herba Hyperici Japonici 3g, Radix Et Caulis Acanthopanacis Senticosi 3g, Folium Elaeagni 3g, Radix Boehmeriae 3g, Radix Tinosporae 3g, Radix Echinopsis 2g, Rhizoma Panacis Japonici 2g put into frying pan, stir-fry 20 minutes with slow fire heating; Then put into drug-decocting appliance, add the pure water of 1500g, boil rear slow fire with high heat and decoct 30 minutes, cooled and filtered removing medicinal residues, gained medicinal liquid is the leukodermic external application Chinese medicine for the treatment of.
Comparative example 1:
Take Herba pterocephali 80g, Radix Berberidis 40g, Folium Microcoris paniculatae 8g, Folium Sauropi 8g, Pterospermi Heterophylli 8g, Radix Sambuci Chiensis 3 parts, Cortex Syingae Amurensis 3g, Herba Hyperici Japonici 3g, Radix Et Caulis Acanthopanacis Senticosi 3g, Folium Elaeagni 3g, Radix Boehmeriae 3g, Radix Tinosporae 3g, Radix Echinopsis 2g, Rhizoma Panacis Japonici 2g put into drug-decocting appliance, add the pure water of 1500g, boil rear slow fire with high heat and decoct 30 minutes, cooled and filtered removing medicinal residues, gained medicinal liquid is the leukodermic external application Chinese medicine of contrast therapy.
In order to verify that external application Chinese medicine of the present invention is for leukodermic therapeutic effect, carries out following clinical trial:
One, clinical data
The routine patients with vitiligo in Bengbu, Anhui Province 96 is selected to carry out clinical observation treatment, wherein male 49 example, women 47 example, 23 to 59 years old ages, 41 years old mean age.Cardinal symptom: skin lesion is depigmentation speckle, be often milky, also can be lightpink, smooth surface is without erythra; White macula boundary is clear, and edge pigment compared with normal skin increases, and in white macula, hair is normal or bleach; Pathological changes is apt to occur in irradiates and damage by friction position by sunlight, and how symmetrical disease damage is; White macula is also often pressed nerve segment distribution and is zonation; Except skin lesion, inside lip, labia, glans penis and foreskin, mucosa is also often got involved; Get rid of other dermatosis.By random for above-mentioned patient, be divided into 4 test group, often organize 24 examples, be respectively treatment group 1, treatment group 2, treatment group 3 and matched group.Wherein, treatment group 1 adopts the treatment by Chinese herbs of the embodiment of the present invention 1; Treatment group 2 adopts the treatment by Chinese herbs of the embodiment of the present invention 2; Treatment group 3 adopts the treatment by Chinese herbs of the embodiment of the present invention 3; Matched group adopts the treatment by Chinese herbs of comparative example 1.
Two, Therapeutic Method
Treatment group 1, treatment group 2, treatment group 3: the Chinese medicine of the embodiment of the present invention is applied to affected part, every day is early, middle and late respectively once, uses 1 month continuously; Other drug is prohibitted the use during clinical trial.
Matched group: the Chinese medicine of comparative example 1 is applied to affected part, every day is early, middle and late respectively once, uses 1 month continuously; Other drug is prohibitted the use during clinical trial.
Three, efficacy assessment standard
1, cure: white macula all disappears, skin complexion recovers normal, and histopathology of skin checks normal;
2, effective: white macula disappears more than 50%, and the colour of skin is clearly better, white macula disappearance portion of tissue pathological examination is normal;
3, effective: white macula disappears and is less than 50%, and the colour of skin take a favorable turn before comparing treatment, and white macula disappearance portion of tissue pathological examination is normal;
4, invalid: white macula without disappearing, or has and increases the weight of trend.
Four, therapeutic outcome
Treatment group 1: cure 5 examples, account for 20.8%; Effective 12 examples, account for 50%; Effective 7 examples, account for 29.2%; Invalid 0 example; Total effective rate 100%; In process of the test, find no any untoward reaction.
Treatment group 2: cure 3 examples, account for 12.5%; Effective 9 examples, account for 37.5%; Effective 12 examples, account for 50%; Invalid 0 example; Total effective rate 100%; In process of the test, find no any untoward reaction.
Treatment group 3: cure 13 examples, account for 54.2%; Effective 11 examples, account for 45.8%; Effective 0 example; Invalid 0 example; Total effective rate 100%; In process of the test, find no any untoward reaction.
Matched group: cure 2 examples, account for 8.4%; Effective 8 examples, account for 33.3%; Effective 14 examples, account for 58.3%; Invalid 0 example; Total effective rate 100%; In process of the test, find no any untoward reaction.
Five, conclusion
1, clinical experiment shows, within the treatment time of one month, the total effective rate of three treatment groups is 100%, and wherein the external application Chinese medicine of embodiment 3 is the highest for vitiligo the fastest, in one month the cure rate that takes effect, reaching 54.2%, is the preferred embodiments of the present invention.Further, external application Chinese medicine of the present invention over the course for the treatment of to patient without any untoward reaction.
2, in the treatment time of 1 month, the external application Chinese medicine of comparative example 1 significantly reduces for leukodermic cure rate embodiment 3 compared with obvious effective rate sum, and this is because the difference of embodiment 3 with comparative example 1 preparation method is: the Chinese crude drug of embodiment 3 is put into drug-decocting appliance again through slow fire parch and decocted with water after 20 minutes; And the Chinese crude drug of comparative example 1 directly decocts with water without slow fire parch.The drug effect of the medicine that visible identical Chinese crude drug optimization formula is obtained by different preparation methoies has very big-difference, and this is also the present inventor's experiment for many years and the technique effect putting into practice favorite outer discovery.
Claims (2)
1. the leukodermic external application Chinese medicine for the treatment of, it is characterized in that, be made up of the Chinese crude drug of following weight portion: Herba pterocephali 60 ~ 100 parts, Radix Berberidis 30 ~ 50 parts, Folium Microcoris paniculatae 1 ~ 15 part, Folium Sauropi 1 ~ 15 part, Pterospermi Heterophylli 1 ~ 15 part, Radix Sambuci Chiensis 1 ~ 5 part, Cortex Syingae Amurensis 1 ~ 5 part, Herba Hyperici Japonici 1 ~ 5 part, Radix Et Caulis Acanthopanacis Senticosi 1 ~ 5 part, Folium Elaeagni 1 ~ 5 part, Radix Boehmeriae 1 ~ 5 part, Radix Tinosporae 1 ~ 5 part, Radix Echinopsis 1 ~ 3 part, Rhizoma Panacis Japonici 1 ~ 3 part; Its preparation method is: the Chinese crude drug taking described weight portion puts into frying pan, stir-fries 20 minutes with slow fire heating; Then put into drug-decocting appliance, add the pure water of 1500 weight portions, boil rear slow fire with high heat and decoct 30 minutes, cooled and filtered removing medicinal residues, gained medicinal liquid is the leukodermic external application Chinese medicine for the treatment of.
2. one as claimed in claim 1 treats leukodermic external application Chinese medicine, it is characterized in that, be made up of the Chinese crude drug of following weight portion: Herba pterocephali 80 parts, Radix Berberidis 40 parts, Folium Microcoris paniculatae 8 parts, Folium Sauropi 8 parts, Pterospermi Heterophylli 8 parts, Radix Sambuci Chiensis 3 parts, Cortex Syingae Amurensis 3 parts, Herba Hyperici Japonici 3 parts, Radix Et Caulis Acanthopanacis Senticosi 3 parts, Folium Elaeagni 3 parts, Radix Boehmeriae 3 parts, Radix Tinosporae 3 parts, Radix Echinopsis 2 parts, Rhizoma Panacis Japonici 2 parts.
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| CN201410385825.XA CN104083445B (en) | 2014-08-07 | 2014-08-07 | One treats leukodermic external application Chinese medicine |
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| CN201410385825.XA CN104083445B (en) | 2014-08-07 | 2014-08-07 | One treats leukodermic external application Chinese medicine |
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| US11123390B2 (en) | 2018-09-18 | 2021-09-21 | Kuwait University | Method for treating vitiligo |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101502577A (en) * | 2009-03-13 | 2009-08-12 | 朱伟菊 | Chinese medicinal external-use liquid for treating vitiligo and preparation method thereof |
| CN101623330A (en) * | 2008-07-08 | 2010-01-13 | 董云 | External applying Chinese medicinal composition for treating vitiligo |
-
2014
- 2014-08-07 CN CN201410385825.XA patent/CN104083445B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101623330A (en) * | 2008-07-08 | 2010-01-13 | 董云 | External applying Chinese medicinal composition for treating vitiligo |
| CN101502577A (en) * | 2009-03-13 | 2009-08-12 | 朱伟菊 | Chinese medicinal external-use liquid for treating vitiligo and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 治疗白癜风的中药外用制剂总结分析;张春艳、许爱娥;《中华中医药学刊》;20120930;第30卷(第9期);2074-2077 * |
| 白癜风治疗药物概况;鲁燕侠等;《现代生物医学进展》;20100731;第10卷(第13期);2587-2589 * |
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