CN104068865B - A kind of method and portable set for measuring blood oxygen saturation - Google Patents
A kind of method and portable set for measuring blood oxygen saturation Download PDFInfo
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- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
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Abstract
The invention discloses a kind of method for measuring blood oxygen saturation, the method includes：First is sent to the skin surface of measured object and measure light, the second measurement light and reference light, and receive the reflected light of the first measurement light, the second measurement light and the reference light；The first difference and the second difference are obtained, wherein, first difference is the difference of the first reflected light and the light intensity rate of change with reference to reflected light；Second difference states the difference of the light intensity rate of change with reference to reflected light and the second reflected light；The ratio x of first difference and second difference is obtained by calculating, and according to the ratio x, calculates blood oxygen saturation y.Accordingly, the present invention also provides a kind of portable set for measuring blood oxygen saturation.The method and portable set provided using the present invention, it is possible to achieve real-time and accurately oxygen saturation measurement.
Description
Technical field
The invention belongs to physiological parameter measurement field, a kind of method for measuring blood oxygen saturation and just is related in particular to
Portable device.
Background technology
Oxygen is the important element for maintaining human normal physiological activity, and the oxygen in air enters blood after human lung exchanges
Liquid, with reference to being sent to whole body on hemoglobin.Hemoglobin is made up of four chains, two α chains and two β chains, each chain
There is one to include a ring-like heme for iron atom.Oxygen is combined on iron atom, by blood transportation.Every gram of hemoglobin can
It is 70 times of blood plasma dissolved oxygen amount with reference to the oxygen of 1.34ml.
With oxyhemoglobin (HbO2) and reduced hemoglobin based on blood oxygen saturation (SO2) characterize human body oxygen
The state of circulation, is the important parameter for judging human body respiration and the circulatory system.Blood oxygen saturation is the oxygen combined by oxygen in blood
The capacity for closing hemoglobin accounts for the percentage of all combinative hemoglobin (Hb) capacity, i.e., the concentration of blood oxygen in blood.Just
The blood oxygen saturation of ordinary person's body arterial blood is 98%, and venous blood is 75%.Typically recognize SpO294% should be normally not less than, 94%
Below for oxygen supply is not enough.
The harm of anoxic is relevant with degree of oxygen deficiency, generation speed and duration.Compensatory is occurred that during hypoxemia first
Heart rate accelerates, and heartbeat and cardiac output increase, and the circulatory system is with the deficiency of the compensatory oxygen content of hyperkinetic state.Blood flow is produced simultaneously
Reallocation, brain and coronal cardioselective are expanded to ensure enough blood supplies.Severe hypoxia, lactic acid is piled up under the internal membrane of heart, ATP
(adenosine triphosphate, atriphos) synthesis is reduced, and produces myocardiac inhibition, causes bradycardia, is received before the phase
Contracting, the reduction of drop in blood pressure and cardiac output, and room occur and quiver etc. arrhythmia cordis or even to stop fighting.Therefore for blood oxygen saturation
Real-time monitoring is extremely important.
In order to avoid blood sampling detection is to the damage caused by human body, primarily now using the nothing that damage is not resulted in human body
Detection method is created to detect blood oxygen saturation.Noninvasive blood oxygen saturation detection is divided into transmission-type and reflective two methods.Wherein,
Transmission-type method analyzes blood oxygen saturation by obtaining by the transmitted light of tissue, because optical signal transmissive is stronger, surveys
Amount accuracy rate is high, therefore the method has clinically obtained extensive use at present.But transmission-type method is suitably applied in skin
Relatively thin place, so as to the transmission of light, therefore has limited application site.Reflective method obtains what is reflected by tissue
Light intensity signal, thus its probe do not limited by riding position, with broader practice prospect.But at present by reflective
The method accuracy rate for measuring blood oxygen saturation is not high, and error is larger.
The content of the invention
In order to the method precision for solving the problems, such as existing reflective measurement blood oxygen saturation is low, efficient difference, the present invention is carried
For a kind of method for measuring blood oxygen saturation.
According to an aspect of the present invention, there is provided it is a kind of measure blood oxygen saturation method, wherein, methods described include step
Suddenly：
A) send first to the skin surface of measured object and measure light, the second measurement light and reference light, and receive described
The reflected light of the first measurement light, the second measurement light and the reference light；
B) the first difference and the second difference are obtained, wherein,
First difference is the difference of the first reflected light and the light intensity rate of change with reference to reflected light；
Second difference is the difference of the light intensity rate of change with reference to reflected light and the second reflected light；
C) the ratio x of first difference and second difference is obtained by calculating, and according to the ratio x, is calculated
Blood oxygen saturation y.
A specific embodiment of the invention, the step c) is further：
The ratio x of first difference and second difference is obtained by calculating, and according to the ratio x, using public affairs
Formula y=nx+m, calculates blood oxygen saturation y；Wherein, n ＞ 0；0 ＜ m ＜ 100.
Another embodiment of the invention,
The wavelength of the first measurement light is 660nm ± 3nm；
The wavelength of the second measurement light is 940nm ± 10nm；
The wavelength of the reference light is 820 ± 10nm.
Another specific embodiment of the invention, the skin surface is the radial artery institute of the measured object
Corresponding wrist skin surface.
According to another aspect of the present invention, there is provided it is a kind of measure blood oxygen saturation portable set, wherein, it is described just
Portable device includes：Light is launched and Optical Receivers, computing module and processing module；
The light transmitting and receiver module, light is measured for sending first to the skin surface of measured object, and second surveys
Amount light and reference light, and receive the reflected light of the first measurement light, the second measurement light and the reference light；
Computing module, for calculating and obtains the first difference and the second difference, wherein, first difference is the first reflection
The difference of light and the light intensity rate of change with reference to reflected light,
Second difference is the difference of the light intensity rate of change with reference to reflected light light intensity and the second reflected light；
Processing module, for calculating and obtains the ratio x of first difference and second difference, and according to the ratio
Value x, calculates blood oxygen saturation y.
A specific embodiment of the invention, the processing module, according to the ratio x, calculates blood oxygen saturation
Degree y, specially：According to the ratio x, using formula y=nx+m, blood oxygen saturation y is calculated；
Wherein, n ＞ 0；0 ＜ m ＜ 100.
Another embodiment of the invention,
The wavelength of the first measurement light is 660nm ± 3nm；
The wavelength of the second measurement light is 940nm ± 10nm；
The wavelength of the reference light is 820nm ± 10nm.
Another specific embodiment of the invention, the skin surface is the radial artery institute of the measured object
Corresponding wrist skin surface.
There is another specific embodiment of the invention, the portable set wrist to wear structure.
Another specific embodiment of the invention, the portable set also includes：
Display module, for showing the blood oxygen saturation.
The present invention sends measurement light and reference light to the skin surface of measurand first, and measurement light and reference are received afterwards
The reflected light of light, and light intensity rate of change using reflected each Shu Guang is calculated the blood oxygen saturation of measurand.Using
The method of reflection obtains the light intensity signal reflected by the test position of measurand, and light intensity signal is strong, thus test probe do not receive
The limitation of riding position, more flexibly.Reference light is added in test process, the intrinsic suction of measurand can be effectively removed
Absorption of the yield to test light so that measurement result is more accurate.
Brief description of the drawings
By the detailed description made to non-limiting example made with reference to the following drawings of reading, it is of the invention other
Feature, objects and advantages will become more apparent upon：
Fig. 1 show an a kind of specific embodiment of the method for the measurement blood oxygen saturation provided according to the present invention
Schematic flow sheet；
Fig. 2 show the graph of a relation of wavelength and absorption coefficient；
Fig. 3 show a kind of structural representation of the portable set of the measurement blood oxygen saturation provided according to the present invention.
Same or analogous reference represents same or analogous part in accompanying drawing.
Specific embodiment
Following disclosure provides many different embodiments or example is used for realizing different structure of the invention.For letter
Change disclosure of the invention, hereinafter the part and setting to specific examples are described.Additionally, the present invention can be in different examples
Middle repeat reference numerals and/or letter.This repetition is for purposes of simplicity and clarity, itself not indicate discussed various
Relation between embodiment and/or setting.It should be noted that part illustrated in the accompanying drawings is not drawn necessarily to scale.This hair
It is bright to eliminate the description to known assemblies and treatment technology and process to avoid being unnecessarily limiting the present invention.
With reference to Fig. 1, Fig. 1 show an a kind of specific reality of the method for the measurement blood oxygen saturation provided according to the present invention
Apply the schematic flow sheet of mode.
Oxygen saturation measurement is changed to the uptake of light based on arterial blood with arteriopalmus.When transmission region artery
During vascular pulsation, arterial blood will change therewith to the uptake of light, and its hetero-organization such as skin, muscle, bone and venous blood
Absorption to light is constant.Specifically, the main applicable object of the method for the measurement blood oxygen saturation that the present invention is provided is the mankind, because
This described measured object generally refers to the mankind for needing to carry out oxygen saturation measurement herein.Those skilled in the art
It should be appreciated that the present invention provide measurement blood oxygen saturation method can also be applied to be directed to have with the mankind it is same or similar
The measurement of the blood oxygen saturation of the mammal of physiological property.
Step S101, sends first and measures light, the second measurement light and reference light, and connect to the skin surface of measured object
Receive the reflected light of the first measurement light, the second measurement light and the reference light.
The reflection method for measuring blood oxygen saturation that the present invention is used, concrete principle is to send light wave, the light wave to tissue
By generating reflected light after tissue reflection, then receive the reflected light and analyze the physiology of the human body that the reflected light is reflected
Situation, so as to reach the purpose of measurement human body blood oxygen saturation.
It is weak in the absworption peak of red light district (600nm~700nm) oxyhemoglobin with reference to Fig. 2.Infrared region (850nm~
1000nm) absworption peak of reduced hemoglobin is weak.Transmission is equal with light intensity rate of change caused by reflection, with absorption coefficient into just
Than.It is preferred, therefore, that the wavelength of the first measurement light is 660nm ± 3nm, for example：657nm, 660nm or 663nm.It is excellent
Choosing, the wavelength of the second measurement light is 940nm ± 10nm, for example：930nm, 940nm or 950nm.
In order to eliminate error, in measurement process, three-beam is increased as reference light.In the wavelength of three-beam
Under, oxyhemoglobin is consistent to absorptivity with reduced hemoglobin, can exclude what human body native mode changed to light intensity
Interference.Preferably, the wavelength of the reference light is 820 ± 10nm, for example：810nm, 820nm or 830nm.
Preferably, above-mentioned skin surface is the wrist skin surface corresponding to the radial artery of measured object.
Two beams are measured light and can be realized using three different lasers or using collection with the transmitting of a branch of reference light
Into laser realize.Additionally, the transmitting of light and reception can also be realized using photoelectric sensor, it is, for example possible to use
NJL5501R chips realize, the chip is a kind of photoelectric sensor that can produce feux rouges and infrared light.
Step S102, obtains the first difference and the second difference, wherein, first difference is the first reflected light anti-with reference
Penetrate the difference of the light intensity rate of change of light；Second difference is the difference of the light intensity rate of change with reference to reflected light and the second reflected light.Can
To understand, the first reflected light is the reflected light of the first measurement light；Second reflected light is the reflected light of the second measurement light；With reference to reflection
The just reflected light of reference light.
Above-mentioned calculating process is needed by analog-digital chip or equipment by the first reflected light, the second reflected light and with reference to anti-
The optical signal for penetrating light is converted into data signal.The chip of digital-to-analogue conversion can be realized many kinds, and if in step S101
Light transmitting and light-receiving are realized using NJL5501R chips, due to having included realizing the hard of digital-to-analogue conversion in NJL5501R chips
Part structure, then additionally need not increase chip or equipment to realize digital-to-analogue conversion.
After conversion, the light intensity rate of change of the first reflected light is designated as a, b, second are designated as with reference to the light intensity rate of change of reflected light
The light intensity rate of change of reflected light is designated as c.Then the first difference is b-a, and the second difference is c-b.
Step S103, the ratio x of first difference and second difference is obtained by calculating, and according to the ratio
X, calculates blood oxygen saturation y.Preferably, blood oxygen saturation is calculated using formula y=nx+m；Wherein, n ＞ 0；0 ＜ m ＜
100.Wherein ratio x=(b-a)/(c-b) is can be seen that from the description of step S102.Blood oxygen saturation y is obtained according to ratio x,
Can be realized using single-chip microcomputer.In the prior art, having various single-chip microcomputers can realize the calculating of data signal to generate physiology
Parameter, for example：MK20DN512VLK10 chips.It is appreciated that in the present invention, the physiological parameter is to refer to blood oxygen saturation y, blood
Oxygen saturation y=nx+m.
Wherein, n ＞ 0, for example, can be 1,3,5 etc. with value；0 ＜ m ＜ 100, for example, can be 2,40,57 etc. with value
Deng.
With reference to Fig. 3, Fig. 3 show a kind of structure of the portable set of the measurement blood oxygen saturation provided according to the present invention
Schematic diagram.
The portable set 20 includes：Light is launched and Optical Receivers 21, computing module 21 and processing module 22.
The light transmitting and receiver module 21, light is measured for sending first to the skin surface 10 of measured object, the
Two measurement light and reference lights, and receive the reflected light of the first measurement light, the second measurement light and the reference light.It is excellent
Choosing, the skin surface 10 of measurand is the wrist skin surface corresponding to the radial artery of measured object.
Preferably, the wavelength of the first measurement light is 660nm ± 3nm, for example：657nm, 660nm or 663nm.It is excellent
Choosing, the wavelength of the second measurement light is 940nm ± 10nm, for example：930nm, 940nm or 950nm.
In order to eliminate error, in measurement process, three-beam is increased as reference light.In the wavelength of three-beam
Under, oxyhemoglobin is consistent to absorptivity with reduced hemoglobin, can exclude what human body native mode changed to light intensity
Interference.Preferably, the wavelength of the reference light is 820 ± 10nm, for example：810nm, 820nm or 830nm.
Preferably, light transmitting and receiver module 21 are photoelectric sensor, for example, NJL5501R chips, the chip is one
Plant the photoelectric sensor that can produce feux rouges and infrared light.
Computing module 22, for calculating and obtains the first difference and the second difference, wherein, first difference is first anti-
The difference of light and the light intensity rate of change with reference to reflected light is penetrated, second difference is the light of the reference reflected light and the second reflected light
The difference of strong rate of change.First reflected light is the launching light of the first measurement light；Second reflected light is the launching light of the second measurement light；Ginseng
Examine the reflected light that reflected light is reference light.
Computing module 22 can be that by the chip or equipment of digital-to-analogue conversion, such as NJL5501R chips.
Having in NJL5501R chips can realize the hardware configuration of digital-to-analogue conversion.After conversion, the light intensity rate of change of the first reflected light is remembered
It is a, b is designated as with reference to the light intensity rate of change of reflected light, the light intensity rate of change of the second reflected light is designated as c.Then the first difference is b-a,
Second difference is c-b.
Processing module 23, for calculating and obtains the ratio x of first difference and second difference, and according to described
Ratio x, calculates blood oxygen saturation y.Preferably, blood oxygen saturation is calculated using formula y=nx+m；Wherein n ＞ 0；0 ＜ m ＜
100.Ratio x=(b-a)/(c-b), blood oxygen saturation y=y=nx+m.Wherein, n ＞ 0, for example, can be 1,3,5 etc. with value
Deng；0 ＜ m ＜ 100, for example, can be 2,40,57 etc. with value.
Blood oxygen saturation y is obtained according to ratio x, can be realized using single-chip microcomputer, therefore processing module 23 can be single
Piece machine or other can realize data signal calculate embedded device.Preferably, the processing module 23 is
MK20DN512VLK10 chips.
Additionally, above-mentioned computing module 22 and processing module 23 can also be by special calculator or application specific processor such as CPU
To realize.
In order to meet the demand of measurement blood oxygen saturation in real time, the portable set 20 needs to carry at any time, and in its institute
The skin lower section being adjacent to will have artery, additionally, the normal of measurand can not be had influence on because the portable set 20 is carried
Activity, it is therefore preferred that the portable set 20 wears structure with wrist.
Preferably, the portable set 20 also includes：Display module, is carrier for showing the blood oxygen saturation
Real-time blood oxygen saturation numerical value is provided.Additionally, the display module can also show the conventional parameters such as time.
Method using the measurement blood oxygen saturation of present invention offer and the portable set using present invention offer can
Accurately and real-time to measure the blood oxygen saturation of measurand by reflective method.
Although being described in detail on example embodiment and its advantage, it should be understood that do not depart from it is of the invention spirit and
In the case of protection domain defined in the appended claims, various change, substitutions and modifications can be carried out to these embodiments.It is right
In other examples, one of ordinary skill in the art should be readily appreciated that while keeping in the scope of the present invention, technique
The order of step can change.
Additionally, range of application of the invention is not limited to technique, mechanism, the system of the specific embodiment described in specification
Make, material composition, means, method and step.From the disclosure, will be easy as one of ordinary skill in the art
Ground understands, for current technique that is existing or will developing later, mechanism, manufacture, material composition, means, method or
Step, the knot that the function or acquisition that wherein their execution are substantially the same with the corresponding embodiment of present invention description are substantially the same
Really, they can be applied according to the present invention.Therefore, appended claims of the present invention are intended to these techniques, mechanism, system
Make, material composition, means, method or step are included in its protection domain.
Claims (6)
1. it is a kind of measure blood oxygen saturation method, wherein, methods described include step：
A) send first to the skin surface of measured object and measure light, the second measurement light and reference light, and receive described first
The reflected light of measurement light, the second measurement light and the reference light；
The wavelength of the first measurement light is 660nm ± 3nm；
The wavelength of the second measurement light is 940nm ± 10nm；
The wavelength of the reference light is 820 ± 10nm；
B) the first difference and the second difference are obtained, wherein,
First difference is the difference of the first reflected light and the light intensity rate of change with reference to reflected light；
Second difference is the difference of the light intensity rate of change with reference to reflected light and the second reflected light；
C) the ratio x of first difference and second difference is obtained by calculating, and according to the ratio x, using formula y
=nx+m, calculates blood oxygen saturation y；
Wherein, n ＞ 0；0 ＜ m ＜ 100.
2. method according to claim 1, wherein, the skin surface is corresponding to the radial artery of the measured object
Wrist skin surface.
3. it is a kind of measure blood oxygen saturation portable set, wherein, the portable set includes：Light is launched and light-receiving mould
Block, computing module and processing module；
The light transmitting and receiver module, light, the second measurement light are measured for sending first to the skin surface of measured object
And reference light, and the reflected light for receiving the first measurement light, the second measurement light and the reference light；
The wavelength of the first measurement light is 660nm ± 3nm；
The wavelength of the second measurement light is 940nm ± 10nm；
The wavelength of the reference light is 820nm ± 10nm；
Computing module, for calculating and obtains the first difference and the second difference, wherein, first difference be the first reflected light with
With reference to the difference of the light intensity rate of change of reflected light,
Second difference is the difference of the light intensity rate of change of the reference reflected light and the second reflected light；
Processing module, for calculating and obtains the ratio x of first difference and second difference, and according to the ratio x,
Using formula y=nx+m, blood oxygen saturation y is calculated；
Wherein, n ＞ 0；0 ＜ m ＜ 100.
4. portable set according to claim 3, wherein, the skin surface is the radial artery of the measured object
Corresponding wrist skin surface.
5. portable set according to claim 3, wherein, there is the portable set wrist to wear structure.
6. portable set according to claim 3, wherein, the portable set also includes：
Display module, for showing the blood oxygen saturation.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410168663.4A CN104068865B (en) | 2014-04-24 | 2014-04-24 | A kind of method and portable set for measuring blood oxygen saturation |
| PCT/CN2015/070723 WO2015161687A1 (en) | 2014-04-24 | 2015-01-15 | Method for measuring blood oxygen saturation and portable device |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410168663.4A CN104068865B (en) | 2014-04-24 | 2014-04-24 | A kind of method and portable set for measuring blood oxygen saturation |
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| CN104068865B (en) * | 2014-04-24 | 2017-05-31 | 辛勤 | A kind of method and portable set for measuring blood oxygen saturation |
| EP3203912B1 (en) | 2014-10-10 | 2021-03-10 | Medtor LLC | System and method for a non-invasive medical sensor |
| CN104688242A (en) * | 2015-03-12 | 2015-06-10 | 深圳欧德蒙科技有限公司 | Physiological parameter detection device and method |
| CN106512160B (en) * | 2016-10-14 | 2019-05-17 | 深圳市理邦精密仪器股份有限公司 | The determination method and device of oxygen transportation parameters |
| US11998298B2 (en) | 2018-02-26 | 2024-06-04 | Biointellisense, Inc. | System and method for a wearable vital signs monitor |
| CN109157224B (en) * | 2018-06-06 | 2021-06-08 | 电子科技大学 | Pulse blood oxygen monitoring system and method with additional reference light source calibration |
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| US6183414B1 (en) * | 1999-04-26 | 2001-02-06 | Michael S. Wysor | Technique for restoring plasticity to tissues of a male or female organ |
| US5040539A (en) * | 1989-05-12 | 1991-08-20 | The United States Of America | Pulse oximeter for diagnosis of dental pulp pathology |
| US6438399B1 (en) * | 1999-02-16 | 2002-08-20 | The Children's Hospital Of Philadelphia | Multi-wavelength frequency domain near-infrared cerebral oximeter |
| CN1239125C (en) * | 2002-04-26 | 2006-02-01 | 武汉一海数字工程有限公司 | Three-wavelength celebral tissue blood oxygen content monitor |
| US7738935B1 (en) * | 2002-07-09 | 2010-06-15 | Pacesetter, Inc. | Methods and devices for reduction of motion-induced noise in pulse oximetry |
| JP4284674B2 (en) * | 2003-01-31 | 2009-06-24 | 日本光電工業株式会社 | Absorbent concentration measuring device in blood |
| US20080208019A1 (en) * | 2007-02-22 | 2008-08-28 | Jerusalem College Of Technology | Modified Pulse Oximetry Technique For Measurement Of Oxygen Saturation In Arterial And Venous Blood |
| CN101248989B (en) * | 2007-02-25 | 2011-10-12 | 香港中文大学 | Monitoring system of physiological parameter |
| US8109882B2 (en) * | 2007-03-09 | 2012-02-07 | Nellcor Puritan Bennett Llc | System and method for venous pulsation detection using near infrared wavelengths |
| US8412296B2 (en) * | 2007-07-20 | 2013-04-02 | General Electric Company | Non-invasive determination of the concentration of a blood substance |
| CN102488525B (en) * | 2011-12-14 | 2014-04-16 | 吉林大学 | Hepatic functional reserve detector capable of removing blood oxygen fluctuation interference |
| CN103610443B (en) * | 2013-11-19 | 2015-07-15 | 上海交通大学 | Near-infrared sensor based muscle group information detection device |
| CN104068865B (en) * | 2014-04-24 | 2017-05-31 | 辛勤 | A kind of method and portable set for measuring blood oxygen saturation |
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