CN104055818A - Wall-broken Erigeron breviscapus preparation - Google Patents
Wall-broken Erigeron breviscapus preparation Download PDFInfo
- Publication number
- CN104055818A CN104055818A CN201310089850.9A CN201310089850A CN104055818A CN 104055818 A CN104055818 A CN 104055818A CN 201310089850 A CN201310089850 A CN 201310089850A CN 104055818 A CN104055818 A CN 104055818A
- Authority
- CN
- China
- Prior art keywords
- preparation
- herba erigerontis
- wall
- ethanol
- breaking cellular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to the technical field of Chinese herbal preparations, specifically to a wall-broken Erigeron breviscapus preparation. A preparation method for the wall-broken Erigeron breviscapus preparation comprises the following steps: crushing Erigeron breviscapus into wall-broken powder; then carrying out ethanol-water wet granulation by controlling the mass of an ethanol solution and the wall-broken powder; carrying out extrusion forming at a certain rotating speed; and then carrying out drying. The preparation method has a high granulation rate; and the prepared wall-broken Erigeron breviscapus preparation has high bioavailability, good stability and good disintegration performance.
Description
Technical field
The present invention relates to tcm field, more specifically, relate to a kind of Herba Erigerontis breaking cellular wall preparation.
Background technology
Superfine communication technique is the new technique developing rapidly in recent years.Effective ingredient in Chinese crude drug is distributed in cell mostly, and conventional decoction pieces can only make part effective ingredient discharge while decoction, utilization rate of active components 10-30%; And employing wall breaking pulverization technology; as the prepared slices of Chinese crude drugs being crushed to 300 order left and right; cell wall breaking rate will reach 86.7%; improve the stripping of effective ingredient in medical material; greatly strengthen its drug effect; utilization rate of active components, more than 90%, reaches and reduces medical material use amount and protection herb resource, also can improve the mass penalty drug effect of medicine simultaneously.But current main superfine powder technology still rests on the stage that traditional Chinese medicine powder is broken to superfine formulation.Because superfine formulation cell wall breaking rate increases, there is the long-pending increase of breaking cellular wall dosage surface, out-of-shape, mobility, bad dispersibility, be easy to moisture absorption, the inherent characteristicses such as poor stability, by its granulation, the stability that improves product, preparation prepared by the present invention has well solved the problem of above existence, reaches the utilization of medical material and use to maximize.
Herba Erigerontis is the dry herb of feverfew Erigeron breviscapus (Vant.) Hand.-Mazz. Erigeron breviscapus (Vant.) Hand-Mazz, have another name called Herba Erigerontis, Aster dubius (Thunb.) Onno, push up grass,
chaoyang, ground, two sunflowers.Its main component containing plant sterol, natural gum (containing galactose), glucoside type resin, glucoside type tannin, volatile oil (being limonene etc.), Jiao's property catechol,
aminoacid, sugar etc., relatively responsive to temperature, poor heat stability.Therefore, if adopt traditional decocting method, easily destroy on the one hand its thermal sensitivity composition, effective ingredient decocts not exclusively on the other hand, causes the loss of effective ingredient.Herba Erigerontis is prepared into Herba Erigerontis micropowder, is conducive to improve the utilization rate of effective ingredient, but simultaneously due to the increase of powder specific surface area, produce and be easy to the moisture absorption, oxidation, rotten etc. shortcoming.Therefore, on the basis that is prepared into micropowder, also need its transformation for further processing, effectively to overcome these unfavorable factors, the therapeutic effect of maximized performance medicine.
Summary of the invention
The application provides the Herba Erigerontis breaking cellular wall that a kind of yield is high, disintegrative good, stability is strong preparation, comprise Herba Erigerontis super-micro wall-broken powder, the sporoderm-broken rate of described super-micro wall-broken powder is 80 ~ 95%, and the density of described Herba Erigerontis breaking cellular wall preparation is 0.15 ~ 0.35g/mL.
The preparation method that a kind of Herba Erigerontis breaking cellular wall preparation is provided again, comprises the following steps,
S1. Herba Erigerontis is carried out to super-micro wall-broken and pulverizes acquisition super-micro wall-broken powder,
S2. ethanol-water solution is that 0.5 ~ 1.3:1 mixes with super-micro wall-broken powder by weight, makes soft material,
S3. extruding obtains wet grain, is drying to obtain.
Ethanol-water solution in described step S2 is preferably that 0.7 ~ 1.1:1 mixes with super-micro wall-broken powder by weight.
The mass fraction of the ethanol of the ethanol-water solution in described step S2 is 20 ﹪～80 ﹪, is preferably 30 ﹪～70 ﹪.
More have the scheme of choosing to be, the mass fraction of the ethanol of the ethanol-water solution in described step S2 is 40 ﹪～65 ﹪, and ethanol-water solution is that 0.9 ~ 1.0:1 mixes with super-micro wall-broken powder by weight.Soft material suitable viscosity under this condition, sieve easily, the yield of finished product is high, and shape is good.
The sporoderm-broken rate of the super-micro wall-broken powder in described step S1 is 80 ~ 95%.
The particle diameter of more than 90% granule of the super-micro wall-broken powder in described step S1 is less than or equal to 41 μ m.
The condition of the extruding in described step S3 is, extruding dynamics 0.05Mpa～1Mpa, and rotating speed 50r/min～100r/min, is preferably, extruding dynamics 0.75Mpa～0.85Mpa, rotating speed 75r/min～85r/min.
The soft material that makes in described step S2 is crossed 10 ~ 30 object screen clothes.
In order to understand better the present invention, below the present invention program's association reaction formula is done to further explaination, it can not serve as the restriction of protection domain of the present invention.
The goal of the invention of the present patent application, is to overcome following technical barrier:
1. although the utilization rate of current breaking cellular wall preparation Chinese medicine ingredients is high, wall cell disruption powder is easy to oxidized, and stability is not high, and drug effect is easily lost;
2. the product that existing herbal species obtains by soft material granulation is difficult to ensure yield, disintegrative and stability simultaneously;
3. some herbal species can not adopt wall cell disruption powder-soft material granulation method to make preparation, as Fructus Lycii, Radix Achyranthis Bidentatae and so on; And the present invention is by the groping of great many of experiments, and the herbal species of suitable wall cell disruption powder-soft material granulation method is screened, and find out the condition of each step.
The invention provides a kind of pelletization simply and not needs the Chinese medicine preparation of binding agent, and obtains when breaking cellular wall and granulated, and has obtained good disintegrative and stability by the adjusting of parameter simultaneously.
A kind of Herba Erigerontis breaking cellular wall preparation provided by the invention, adopt following technical scheme: Herba Erigerontis is carried out to wall breaking pulverization and obtain wall cell disruption powder, add ethanol-water solution fully to mix, make soft material, further extruding obtains wet grain again, the dry Herba Erigerontis breaking cellular wall preparation that obtains, the sporoderm-broken rate of described superfine powder is 80 ~ 95%.Herba Erigerontis breaking cellular wall preparation prepared by the present invention, can make consumer in the time taking without decoction, by can make with warm boiled water effective ingredient utilization maximize.
Herba Erigerontis first can be crushed to 100 orders, more further carry out micronizing, make in micropowder 90% or the grain diameter of above (such as being 90%, 91%, 92%, 93%, 94% or 95%) be less than or equal to 41 μ m.The superfine powder adopting in scheme, 90% grain diameter be 14-45 μ m(such as can be 15,17,19,21,23,25,27,30,32,34,36 or 38 μ m), preferably 41 μ m.But what those skilled in the art can know understanding is that these embodiment can not be served as restriction of the present invention, as long as particle diameter is less than or equal to 45 μ m and all can realizes the present invention.
The present invention adopts ethanol-water solution to carry out wet granulation, and its outstanding advantage is without any need for other additives, can make micropowder of the present invention by follow-up granulation, dry, becomes fleabane preparation granule.But in this process, should adopt the ethanol-water solution of which kind of concentration, and proportioning between this solution and ultra-fine powder, all to need the strict parameter of controlling, to make the characteristic applicable to Herba Erigerontis breaking cellular wall powder such as humidity, solid content, viscosity of soft material, making between powder to have effective adhesive; Further by the setting of specific squeezing parameter, soft material extruding is become to density, sizeable Herba Erigerontis granular preparation, makes its density/loft suitable, thus dry become finished product after, even if be positioned in air at room temperature, also can prevent the Oxidation of air.And, the finished product obtaining, in the time using warm boiled water, ultra-fine powder can comparatively promptly scatter, and makes effective ingredient dissolve rapidly and fully and spread, and improves utilization rate of active components.
The present invention, by repeatedly groping, has finally chosen following scheme:
When wet granulation, in the ethanol-water solution adopting, the mass fraction of ethanol is 20% ~ 80%; Preferably, the mass fraction of ethanol is 30 ﹪～70 ﹪, is more preferably 40 ﹪～65 ﹪.Micropowder than 1:0.5 ~ 1.3, is 1:0.5～1.3 with ethanol-water solution by weight, is preferably 1:0.7～1.1.
In the time that soft material extruding is become to wet grain, be preferably controlled at following condition: adopt prepackage 10 order～30 eye mesh screens, extruding dynamics 0.05Mpa～1Mpa, rotating speed 50r/min～100r/min; Preferably, extruding dynamics 0.5Mpa～0.75Mpa, rotating speed 75r/min～85r/min.
The wet grain particle diameter of extruding gained is 16 order ~ 30 orders, and when dry, baking temperature is 45 DEG C ~ 80 DEG C, and be 0.5h ~ 2.5h drying time.
The density of the Herba Erigerontis breaking cellular wall preparation obtaining is 0.24g/ml～0.45g/ml.
Compared with prior art, the present invention has following beneficial effect:
1. the fleabane preparation obtaining by method of the present invention, its utilization rate of active components improves greatly, and utilization rate is close to 100%;
2. the present invention is by groping to obtain suitable wet granulation technology, make pelletization except the adding of alcohol-water, do not introduce other any additives, can obtain the soft material of solid content, modest viscosity, successfully to push granulating technique, the Chinese medicinal granule stability forming is strong, is difficult for collapsing rotten in storage and transportation.
3. extruding condition of the present invention has been groped suitable rotating speed and extruding force, makes thus stickiness, Herba Erigerontis granular preparation that density is moderate, obtain finished product stability strong in, take in process and make again its easy disintegrate disperse, be convenient to warm boiled water.4. conventionally it is believed that in the time that superfine powder carries out wet granulation, what control soft material molding is mainly the concentration of alcohol of ethanol water, but the present invention finds, although the concentration of alcohol of ethanol water forms effect to soft material, but the mass ratio of superfine powder and ethanol water is also one of essential condition, the present invention, by the control of the mass ratio to ethanol-water solution and super-micro wall-broken powder, reaches and obtains the good soft material of shape, for final breaking cellular wall preparation provides a good basis.
4. conventionally it is believed that in the time that superfine powder carries out wet granulation, what control soft material molding is mainly the concentration of alcohol of ethanol water, but the present invention finds, although the concentration of alcohol of ethanol water forms effect to soft material, but the mass ratio of superfine powder and ethanol water is also one of essential condition, the present invention, by the control of the mass ratio to ethanol-water solution and super-micro wall-broken powder, reaches and obtains the good soft material of shape, for final breaking cellular wall preparation provides a good basis.
5. Herba Erigerontis, act as the headache nasal obstruction that cures cold, rheumatic arthralgia, paralysis, acute gastritis, infantile malnutrition, traumatic injury, the baicalin dissolution rate of Herba Erigerontis breaking cellular wall preparation of the present invention is higher than Herba Erigerontis decoction pieces, and its effective ingredient can make Herba Erigerontis breaking cellular wall preparation of the present invention can also be applied to the preparation containing scutellarin medicine.
Detailed description of the invention
Further describe the present invention below in conjunction with specific embodiment.Unless stated otherwise, reagent, equipment and the method that the present invention adopts is the conventional commercial reagent of the art, equipment and the conventional method using.
Embodiment 1:
Get the clean medical material of Herba Erigerontis, after the coarse powder of coarse pulverization to 100 order left and right, be broken in micropowder through superfine powder the powder that 90% grain diameter is less than or equal to 41 μ m, add ethanol-water solution (ethanol mass fraction is 20%) wet method soft material processed, solution and micropowder addition are than 0.5:1(by weight), after mixing, through pre-installing 20 mesh sieves, select extruding rotating speed 50r/min, extruding dynamics 1MPa wet granular processed, in wet granular transposition heated-air circulation oven, sets 80 DEG C of baking temperatures, dry 2.5h, to dry, obtains Herba Erigerontis breaking cellular wall preparation after granulate screening.
Remarks: full marks are in 10.
Embodiment 2:
Get the clean medical material of Herba Erigerontis, after the coarse powder of coarse pulverization to 100 order left and right, be broken in micropowder through superfine powder the powder that 90% grain diameter is less than or equal to 41 μ m, add ethanol-water solution (ethanol mass fraction is 30%) wet method soft material processed, solution and micropowder addition are than 0.6:1(by weight), after mixing, through pre-installing 10 mesh sieves, select extruding rotating speed 55r/min, extruding dynamics 0.8MPa wet granular processed, in wet granular transposition vacuum microwave drying case, sets 45 DEG C of baking temperatures, dry 0.75h, to dry, obtains Herba Erigerontis breaking cellular wall preparation after granulate screening.
Remarks: full marks are in 10.
Embodiment 3:
Get the clean medical material of Herba Erigerontis, after the coarse powder of coarse pulverization to 100 order left and right, be broken in micropowder through superfine powder the powder that 90% grain diameter is less than or equal to 41 μ m, add ethanol-water solution (ethanol mass fraction is 40%) wet method soft material processed, solution and micropowder addition are than 0.7:1(by weight), after mixing, through pre-installing 30 mesh sieves, select extruding rotating speed 80r/min, extruding dynamics 0.3MPa wet granular processed, in wet granular transposition heated-air circulation oven, sets 80 DEG C of baking temperatures, dry 2.5h, to dry, obtains Herba Erigerontis breaking cellular wall preparation after granulate screening.
Remarks: full marks are in 10.
Embodiment 4:
Get the clean medical material of Herba Erigerontis, after the coarse powder of coarse pulverization to 100 order left and right, be broken in micropowder through superfine powder the powder that 90% grain diameter is less than or equal to 41 μ m, add ethanol-water solution (ethanol mass fraction is 55%) wet method soft material processed, solution and micropowder addition are than 0.9:1(by weight), after mixing, through pre-installing 30 mesh sieves, select extruding rotating speed 70r/min, extruding dynamics 0.6MPa wet granular processed, in wet granular transposition vacuum microwave drying case, sets 50 DEG C of baking temperatures, dry 0.5h, to dry, obtains Herba Erigerontis breaking cellular wall preparation after granulate screening.
Remarks: full marks are in 10.
Embodiment 5:
Get the clean medical material of Herba Erigerontis, after the coarse powder of coarse pulverization to 100 order left and right, be ground in micropowder through micronizing the powder that 90% grain diameter is less than or equal to 41 μ m, add ethanol-water solution (second mass fraction is 70%) wet method soft material processed, solution and micropowder addition are than 1.1:1(by weight), after mixing, through pre-installing 20 mesh sieves, select extruding rotating speed 100r/min, extruding dynamics 0.05MPa wet granular processed, in wet granular transposition heated-air circulation air box, sets 70 DEG C of baking temperatures, dry 2.0h, to dry, obtains Herba Erigerontis breaking cellular wall preparation after granulate screening.
Remarks: full marks are in 10.
Embodiment 6:
Get the clean medical material of Herba Erigerontis, after the coarse powder of coarse pulverization to 100 order left and right, be ground in micropowder through micronizing the powder that 90% grain diameter is less than or equal to 41 μ m, the solution wet method soft material processed that the mass fraction that adds ethanol-water solution is 75%, solution and micropowder addition are than 1.2:1(by weight), after mixing, through pre-installing 20 mesh sieves, select extruding rotating speed 90r/min, extruding dynamics 0.2MPa wet granular processed, adopts airpillow-dry, sets 80 DEG C of dry inlet temperature, dry 1.0h, to dry, obtains Herba Erigerontis breaking cellular wall preparation after granulate screening.
Remarks: full marks are in 10.
Embodiment 7:
Get the clean medical material of Herba Erigerontis, after the coarse powder of coarse pulverization to 100 order left and right, be ground in micropowder through micronizing the powder that 90% grain diameter is less than or equal to 41 μ m, add ethanol-water solution (second mass fraction is 80%) wet method soft material processed, solution and micropowder addition are than 1.3:1(by weight), after mixing, through pre-installing 20 mesh sieves, select extruding rotating speed 95r/min, extruding dynamics 0.15MPa wet granular processed, in wet granular transposition heated-air circulation air box, sets 70 DEG C of baking temperatures, dry 2.0h, to dry, obtains Herba Erigerontis breaking cellular wall preparation after granulate screening.
Remarks: full marks are in 10.
Embodiment 8:
Get the clean medical material of Herba Erigerontis, after the coarse powder of coarse pulverization to 100 order left and right, be ground in micropowder through micronizing the powder that 90% grain diameter is less than or equal to 41 μ m, add ethanol-water solution (second mass fraction is 55%) wet method soft material processed, solution and micropowder addition are than 1.0:1(by weight), after mixing, through pre-installing 20 mesh sieves, select extruding rotating speed 75r/min, extruding dynamics 0.65MPa wet granular processed, in wet granular transposition heated-air circulation air box, sets 70 DEG C of baking temperatures, dry 2.0h, to dry, obtains Herba Erigerontis breaking cellular wall preparation after granulate screening.
Remarks: full marks are in 10.
Embodiment 9:
Get the clean medical material of Herba Erigerontis, after the coarse powder of coarse pulverization to 100 order left and right, be broken in micropowder through superfine powder the powder that 90% grain diameter is less than or equal to 41 μ m, add ethanol-water solution (ethanol mass fraction is 40%) wet method soft material processed, solution and micropowder addition are than 0.9:1(by weight), after mixing, through pre-installing 10 mesh sieves, select extruding rotating speed 70r/min, extruding dynamics 0.7MPa wet granular processed, in wet granular transposition vacuum microwave drying case, sets 45 DEG C of baking temperatures, dry 0.75h, to dry, obtains Herba Erigerontis breaking cellular wall preparation after granulate screening.
Remarks: full marks are in 10.
Embodiment 10:
Get the clean medical material of Herba Erigerontis, after the coarse powder of coarse pulverization to 100 order left and right, be broken in micropowder through superfine powder the powder that 90% grain diameter is less than or equal to 41 μ m, add ethanol-water solution (ethanol mass fraction is 80%) wet method soft material processed, solution and micropowder addition are than 1.0:1(by weight), after mixing, through pre-installing 30 mesh sieves, select extruding rotating speed 60r/min, extruding dynamics 0.4MPa wet granular processed, in wet granular transposition vacuum microwave drying case, sets 50 DEG C of baking temperatures, dry 0.5h, to dry, obtains Herba Erigerontis breaking cellular wall preparation after granulate screening.
Remarks: full marks are in 10.
Embodiment 11:
Get the clean medical material of Herba Erigerontis, after the coarse powder of coarse pulverization to 100 order left and right, be ground in micropowder through micronizing the powder that 90% grain diameter is less than or equal to 41 μ m, add ethanol-water solution (second mass fraction is 55%) wet method soft material processed, solution and micropowder addition are than 1.1:1(by weight), after mixing, through pre-installing 20 mesh sieves, select extruding rotating speed 75r/min, extruding dynamics 0.65MPa wet granular processed, in wet granular transposition heated-air circulation air box, sets 70 DEG C of baking temperatures, dry 2.0h, to dry, obtains Herba Erigerontis breaking cellular wall preparation after granulate screening.
Remarks: full marks are in 10.
Embodiment 12:
Get the clean medical material of Herba Erigerontis, after the coarse powder of coarse pulverization to 100 order left and right, be ground in micropowder through micronizing the powder that 90% grain diameter is less than or equal to 41 μ m, add ethanol-water solution (second mass fraction is 55%) wet method soft material processed, solution and micropowder addition are than 0.7:1(by weight), after mixing, through pre-installing 20 mesh sieves, select extruding rotating speed 75r/min, extruding dynamics 0.65MPa wet granular processed, in wet granular transposition heated-air circulation air box, sets 70 DEG C of baking temperatures, dry 2.0h, to dry, obtains Herba Erigerontis breaking cellular wall preparation after granulate screening.
Remarks: full marks are in 10.
Embodiment 13:
Get the clean medical material of Herba Erigerontis, after the coarse powder of coarse pulverization to 100 order left and right, be broken in micropowder through superfine powder the powder that 90% grain diameter is less than or equal to 41 μ m, add ethanol-water solution (ethanol mass fraction is 65%) wet method soft material processed, solution and micropowder addition are than 1.1:1(by weight), after mixing, through pre-installing 30 mesh sieves, select extruding rotating speed 60r/min, extruding dynamics 0.5MPa wet granular processed, in wet granular transposition vacuum microwave drying case, sets 50 DEG C of baking temperatures, dry 0.5h, to dry, obtains Herba Erigerontis breaking cellular wall preparation after granulate screening.
Remarks: full marks are in 10.
Embodiment 14:
Get the clean medical material of Herba Erigerontis, after the coarse powder of coarse pulverization to 100 order left and right, be broken in micropowder through superfine powder the powder that 90% grain diameter is less than or equal to 41 μ m, add ethanol-water solution (ethanol mass fraction is 60%) wet method soft material processed, solution and micropowder addition are than 1.0:1(by weight), after mixing, through pre-installing 30 mesh sieves, select extruding rotating speed 110r/min, extruding dynamics 1.1MPa wet granular processed, in wet granular transposition heated-air circulation oven, sets 80 DEG C of baking temperatures, dry 2.5h, to dry, obtains Herba Erigerontis breaking cellular wall preparation after granulate screening.
Remarks: full marks are in 10.
Embodiment 15:
Get the clean medical material of Herba Erigerontis, after the coarse powder of coarse pulverization to 100 order left and right, be broken in micropowder through superfine powder the powder that 90% grain diameter is less than or equal to 45 μ m, add ethanol-water solution (ethanol mass fraction is 60%) wet method soft material processed, solution and micropowder addition are than 1.0:1(by weight), after mixing, through pre-installing 30 mesh sieves, select extruding rotating speed 40r/min, extruding dynamics 0.03MPa wet granular processed, in wet granular transposition heated-air circulation oven, sets 85 DEG C of baking temperatures, dry 2.5h, to dry, obtains Herba Erigerontis breaking cellular wall preparation after granulate screening.
Remarks: full marks are in 10.
Get 1 ~ 8 lower finished product of embodiment by end product quality standard test, result all meets regulation requirement under the relevant dosage form item of Chinese Pharmacopoeia, and result is as shown in table 1.
The quality standard assay of the each embodiment of table 1.
Further by conventional to 1 ~ 8 lower Herba Erigerontis breaking cellular wall preparation of embodiment and Herba Erigerontis micropowder, the conventional decoction pieces of Herba Erigerontis, using character, moisture and scutellarin as evaluation index, three is placed on 40 DEG C ± 2 DEG C of temperature after all adopting sealed plastic bag encapsulation, places each preparation stability of post-evaluation in 3 months under the condition of relative humidity 75% ± 5%.Result is as shown in table 2 below:
The accelerated stability comparing result of the each sample of table 2.
Dissolution is the important indicator of evaluating drug bioavailability, a step is by above accelerated stability test sample again: embodiment 8 samples, Herba Erigerontis micropowder sample and Herba Erigerontis decoction pieces three, according to 2010 version " Chinese Pharmacopoeia " (two) annex XC " dissolution method " lower second " an oar method " test.The Herba Erigerontis breaking cellular wall preparation of having placed respectively Herba Erigerontis micropowder, Herba Erigerontis decoction pieces and the embodiment 8 of 30 days, 60 days, 90 days that before getting, once experiment obtains.Get simulated gastric fluid 1000ml, keep 37 DEG C ± 0.5 DEG C of temperature, rotating speed 90r/min, each sample thief 5g, add in simulated gastric fluid, respectively at 10,20,30,40,50,60,90, when 120min, each sampling 5ml(supplies sampling amount simultaneously) measure scutellarin amount, shown in result table 3.
The Dissolution Rate Testing result of the each sample of table 3.
Wherein under same time, the scutellarin dissolution rate of the obtained Herba Erigerontis breaking cellular wall of embodiment 8 preparation, higher than the dissolution rate of Herba Erigerontis superfine powder, and experimental results show that the needed dissolution time of the obtained Herba Erigerontis breaking cellular wall of embodiment 8 preparation is also shorter.That is to say, not only dissolution time is short to adopt the scutellarin of the Herba Erigerontis breaking cellular wall preparation that makes of the inventive method, and in the unit interval stripping quantity also relatively Herba Erigerontis wall cell disruption powder have obvious increase.
Claims (10)
1. a Herba Erigerontis breaking cellular wall preparation, is characterized in that, comprises Herba Erigerontis super-micro wall-broken powder, and the particle diameter of more than 90% granule of described super-micro wall-broken powder is less than or equal to 41 μ m, and the bulk density of described Herba Erigerontis breaking cellular wall preparation is 0.15 ~ 0.35g/mL.
2. a preparation method for Herba Erigerontis breaking cellular wall preparation, is characterized in that, comprise the following steps,
S1. Herba Erigerontis is carried out to super-micro wall-broken and pulverizes acquisition super-micro wall-broken powder,
S2. ethanol-water solution is that 0.5 ~ 1.3:1 mixes with super-micro wall-broken powder by weight, makes soft material,
S3. extruding obtains wet grain, is drying to obtain.
3. the preparation method of Herba Erigerontis breaking cellular wall preparation according to claim 2, is characterized in that, the ethanol-water solution in described step S2 is that 0.7 ~ 1.1:1 mixes with super-micro wall-broken powder by weight.
4. the preparation method of Herba Erigerontis breaking cellular wall preparation according to claim 2, is characterized in that, the mass fraction of the ethanol of the ethanol-water solution in described step S2 is 20 ﹪～80 ﹪.
5. the preparation method of Herba Erigerontis breaking cellular wall preparation according to claim 4, is characterized in that, the mass fraction of the ethanol of the ethanol-water solution in described step S2 is 30 ﹪～70 ﹪.
6. according to the preparation method of the arbitrary described Herba Erigerontis breaking cellular wall preparation of claim 2 to 5, it is characterized in that, the mass fraction of the ethanol of the ethanol-water solution in described step S2 is 40 ﹪～65 ﹪, and ethanol-water solution is that 0.9 ~ 1.0:1 mixes with super-micro wall-broken powder by weight.
7. the preparation method of Herba Erigerontis breaking cellular wall preparation according to claim 2, is characterized in that, the particle diameter of more than 90% granule of the super-micro wall-broken powder in described step S1 is less than or equal to 41 μ m.
8. the preparation method of Herba Erigerontis breaking cellular wall preparation according to claim 2, is characterized in that, the condition of the extruding in described step S3 is to push dynamics 0.05Mpa～1Mpa, rotating speed 50r/min～100r/min.
9. the preparation method of Herba Erigerontis breaking cellular wall preparation according to claim 9, is characterized in that, the condition of the extruding in described step S3 is to push dynamics 0.5Mpa～0.75Mpa, rotating speed 75r/min～85r/min.
10. an application for Herba Erigerontis breaking cellular wall preparation claimed in claim 1, is characterized in that, the application of described Herba Erigerontis breaking cellular wall preparation in the preparation of scutellaria glycosides medicine.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310089850.9A CN104055818B (en) | 2013-03-20 | 2013-03-20 | A kind of erigeron breviscapus broken wall preparation |
| HK15101630.7A HK1201170A1 (en) | 2013-03-20 | 2015-02-13 | A preparation of ultra-fine granulated powder of erigerontis herba |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310089850.9A CN104055818B (en) | 2013-03-20 | 2013-03-20 | A kind of erigeron breviscapus broken wall preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104055818A true CN104055818A (en) | 2014-09-24 |
| CN104055818B CN104055818B (en) | 2018-08-21 |
Family
ID=51543937
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310089850.9A Active CN104055818B (en) | 2013-03-20 | 2013-03-20 | A kind of erigeron breviscapus broken wall preparation |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN104055818B (en) |
| HK (1) | HK1201170A1 (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101147746B (en) * | 2006-09-18 | 2011-02-16 | 中山市中智药业集团有限公司 | Method for processing traditional Chinese herbs broken wall powder |
| CN102670666A (en) * | 2011-03-16 | 2012-09-19 | 四川金岁方药业有限公司 | Preparation method of finest traditional Chinese medicine powder |
-
2013
- 2013-03-20 CN CN201310089850.9A patent/CN104055818B/en active Active
-
2015
- 2015-02-13 HK HK15101630.7A patent/HK1201170A1/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101147746B (en) * | 2006-09-18 | 2011-02-16 | 中山市中智药业集团有限公司 | Method for processing traditional Chinese herbs broken wall powder |
| CN102670666A (en) * | 2011-03-16 | 2012-09-19 | 四川金岁方药业有限公司 | Preparation method of finest traditional Chinese medicine powder |
Non-Patent Citations (1)
| Title |
|---|
| 南京中医药大学编著: "《中药大辞典》", 31 December 2006 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104055818B (en) | 2018-08-21 |
| HK1201170A1 (en) | 2015-08-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102631377B (en) | Cordyceps sinensis freeze-dried nano powder tablet and preparation method thereof | |
| WO2019205829A1 (en) | Preparation method for additive-free chinese herbal medicine wall-broken powder granular preparation | |
| CN104055813B (en) | A kind of Radix Notoginseng broken wall preparation | |
| CN104056074A (en) | Wall-broken tall gastrodia tuber preparation | |
| CN104055832B (en) | A kind of Radix Astragali broken wall preparation | |
| CN104055843B (en) | A kind of Radix Salviae Miltiorrhizae broken wall preparation | |
| CN104056069A (en) | Preparation method for wall-broken dendrobium preparation | |
| CN102048765B (en) | Method for preventing traditional Chinese medicinal extract powder from absorbing moisture and agglomerating | |
| CN104055821A (en) | Preparation method for wall-broken epimedium preparation | |
| CN104055835A (en) | Beautiful millettia root wall-broken preparation | |
| CN104055819B (en) | A kind of chrysanthemum broken wall preparation | |
| CN104055818A (en) | Wall-broken Erigeron breviscapus preparation | |
| CN104055825B (en) | A kind of Radix Codonopsis broken wall preparation | |
| CN104055814A (en) | Preparation method of American ginseng wall-broken preparation | |
| CN104055820B (en) | A kind of Herba Saussureae Involueratae broken wall preparation | |
| CN103356815B (en) | Forming method of granules for regulating qi and reducing phlegm | |
| CN104055863B (en) | A kind of Rhizoma Polygoni Cuspidati breaking cellular wall preparation | |
| CN104055857A (en) | Cistanche wall-broken preparation | |
| CN104055826A (en) | Rhodiola rosea wall-broken preparation | |
| CN104055839A (en) | Wall-broken Lamiophlomis rotata preparation | |
| CN114848742B (en) | Preparation method of lung-heat clearing and fire suppressing capsule | |
| CN104055827A (en) | Gynostemma pentaphyllum wall-broken preparation | |
| CN104055815B (en) | A kind of red ginseng broken wall preparation | |
| CN104055806A (en) | Wall-broken Chinese yew preparation | |
| CN104055809B (en) | A kind of Radix Angelicae Sinensis broken wall preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1201170 Country of ref document: HK |
|
| CB03 | Change of inventor or designer information |
Inventor after: Cheng Jinle Inventor after: Chen Yongjun Inventor after: Xu Jiyin Inventor after: Chen Jinmei Inventor after: Liang Xueliang Inventor before: Cheng Jinle Inventor before: Chen Yongjun Inventor before: Su Guanfeng Inventor before: Chen Jinmei Inventor before: Liang Xueliang |
|
| CB03 | Change of inventor or designer information | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |