CN104055776A - Medical irrigating fluid - Google Patents
Medical irrigating fluid Download PDFInfo
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- CN104055776A CN104055776A CN201410291651.0A CN201410291651A CN104055776A CN 104055776 A CN104055776 A CN 104055776A CN 201410291651 A CN201410291651 A CN 201410291651A CN 104055776 A CN104055776 A CN 104055776A
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- methyl
- pyrimidine
- tetrahydrochysene
- hydroxyl
- carboxylic
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Abstract
The invention discloses a medical irrigating fluid, which comprises 1,4,5,6-tetrahydryl-2-methyl-4-pyrimidine carboxylic acid or 1,4,5,6-tetrahydryl-2-methyl-5-hydroxyl-4-pyrimidine carboxylic acid and water for injection, in addition, the medical irrigating fluid can contain medically acceptable preservative and/or pH regulator. According to the medical irrigating fluid, people perform a series of animal experiments, the research shows that the medical irrigating fluid has an excellent irrigation effect and safety, and plays a good role in preventing postoperation tissue adhesion and infection.
Description
Technical field
The present invention relates to field of medicaments, particularly a kind of Medical washing fluid.
Background technology
Medical washing fluid (Irrigating Solution) is a kind of for cleaning the liquid of the histoorgans such as body cavities, mucosa, as Ophthalmologic irrigation solutions (Intraocular Irrigating Solution), nasal wash (Nasal Irrigation), surgical flush fluid (Surgical Irrigation Fluids), be widely used clinically at present.Medical washing fluid is microorganism, the remnant tissue for removing human body mucosa or tract by modes such as flushing or lavations conventionally, leniently expand mucosal spaces and remove residual blood and cut and organize from operative region, improve operative region environment, strengthen operative region definition, reduce the rear tissue adhesion of operation, alleviate postoperative hemorrhage etc.At present, numerous flushing liquors have been developed clinically as Ophthalmologic irrigation solutions, nasal wash, vaginal washing fluid, Minimally Invasive Surgery cleanout fluid, electrocision flushing liquor etc.
Although it is clinical that numerous flushing liquors have been applied to, the problem of relevant its safety also seldom draws attention.Pharmacologist is also seldom paid attention to this solution, because they are considered non-medical substance.Yet the side effect causing in Medical washing fluid application process, has proposed higher security requirement to the characteristic of Medical washing fluid.
Desirable Medical washing fluid, except having the effects such as desired degerming, cleaning, also should meet following requirement: (1) is aseptic: because Medical washing fluid can be absorbed, enter blood circulation, therefore answer absolutesterility; (2) nontoxic: Medical washing fluid and metabolite thereof are nontoxic to body; (3) haemolysis not; (4) there is diuresis, promote self excretion; (5) metabolite is few and harmless; (6) cheap, crystallinity is low, easily preparation; (7) transparency is good, viscosity is lower, is conducive to operation technique.
All there are clinically at present certain shortcomings and limitations in conventional Medical washing fluid:
Disinfectant solution: itself has sterilization functions disinfectant solution, but easily absorb and cause the side effect such as hemoglobinuria (patent publication No. CN1499964 A; March 15 2002 patent application day; Patent applicant Aga company).
Glucose Liquid: though conventional slightly hypotonic medium or isotonic solution have not the advantages such as haemolysis, its transparency is poor, and impact is observed, and viscosity is large, make the impact operation of being clamminess of glove utensil, and this can cause blood sugar increasing as sugary soln.
Glycine liquid: glycine liquid is non essential amino acid, its 1.1% or 1.5% solution can reduce to a certain extent glycine and be absorbed by tissue, and so absorption still cannot be avoided, and Yin Qiyi sees through blood brain barrier, absorption meeting can suppress central nervous system, causes hyperammonemia and oxaluria.The multinomial experiment of carrying out in recent years confirms, when 1.5% glycine solution is used in Transurethral prostatic electroresection A, do not show expected effect, 2.2% glycine solution has higher toxicity, the undesirable reason of its result of use comprises tissue injury's increase or mortality rate rising etc., and the absorption of glycine may be one of bad reason of its effect.Therefore in the recent period existing Research Literature suggestion is cancelled, and the application of 1.5% glycine solution in electrotomy is (referring to document: author: the 1.5% for irrigation should be abandoned. periodical phase of Hahn RG. title: Glycine rolls up and the page number: Urol Int. 2013; 91 (3): 249-55.).
Mannitol solution: commonly using is 5% solution, 79%～89% discharges through glomerular filtration.It has diuresis, therefore can promote the excretion of self, but because mannitol is mainly through renal excretion, therefore when merging nephropathy, can further extend its half-life because excretion is affected, thus the recovery of body fluid balance and cardio-pulmonary function affected.
From above-mentioned, desirable Medical washing fluid is antibacterial except having, cleaning action, also should reduce viscosity, enhance the transparency, reduce as far as possible interior absorption of body of solute in flushing liquor, prevent haemolysis, can maintain surgical field of view clear, prevent postoperative infection and tissue adhesion's generation.
Chinese patent CN 201310239823(publication number CN103271939 A, June 17 2013 applying date) a kind of operation anti-sticking flush fluid is disclosed, can prevent the generation of tissue adhesion after performing the operation.But further experiment is found, though this flushing liquor has the effect of good prevention of postoperative adhesion, prevention of postoperative infection effect is limited, and easily in body, absorb, and then cause multiple side effect.Although China Patent Publication No. CN103271939 A discloses prescription and the purposes of flushing liquor, and unexposed its mechanism of action, its mechanism having side effects is still not clear.
Summary of the invention
For above-mentioned prior art, the problem existing for overcoming prior art, the object of this invention is to provide a kind of Medical washing fluid.
The present invention is achieved by the following technical solutions:
A Medical washing fluid, consists of following component:
A, (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid, Isosorbide-5-Nitrae, a kind of in 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic;
B, water for injection;
C, optional pharmaceutically acceptable antiseptic;
D, optional pharmaceutically acceptable pH adjusting agent;
(S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid, Isosorbide-5-Nitrae in described Medical washing fluid, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl
The mass percent concentration of-4-pyrimidine carboxylic is 0.5～30%.
Described solute is Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic.
Described solute is (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid.
The mass percent concentration of described solute is 0.1～10%.
The mass percent concentration of described solute is 0.1～5%.
The mass percent concentration of described solute is 0.1～2%.
Described pharmaceutically acceptable antiseptic is benzalkonium bromide.
Described pharmaceutically acceptable pH adjusting agent is sodium citrate.
" mass percent concentration of solute " of the present invention is that the quality with solute accounts for the concentration that the percentage of the quality of complete soln recently represents.Computing formula is mass percent concentration=(solute quality/solution quality) * 100%.This is known to those skilled in the art.
Herein, certain component can not contain this component for " optional " refers to can contain also.
The present inventor is through experimental studies have found that, flushing liquor of the present invention has good cleaning, osmotic pressure regulating action, and there is suitable viscosity, transparency and non-conductive, its solute composition is single, but can reduce unexpectedly the side effect that flushing liquor absorbs and causes, and can prevent the generation of postoperative tissue adhesion and infection, compare and there is better effect, higher safety with the disclosed flushing liquor of patent publication No. CN103271939 A.Although China Patent Publication No. CN103271939 A discloses prescription and the purposes of flushing liquor, but and unexposed its mechanism of action, the composition that it has side effects and the mechanism of absorbed into serum are still not clear, prior art is very limited about reducing the systemic mode of flushing liquid, and rarely has clear and definite rule can supply to follow.And flushing liquor of the present invention, solute composition is single, prescription is simple, when can keep better developing result, effectively reduce interior absorption of body of flushing liquor, can effectively reduce its side effect, comprise and reduce mucous membrane irritation (ear, nose, larynx zest, peritoneum zest), hemolytic etc., there is unexpected effect.
The specific embodiment
Below in conjunction with embodiment, the present invention is further explained.Should be understood that, following examples are only for explaining the present invention, rather than limit the scope of the invention.
Embodiment 1 is containing Isosorbide-5-Nitrae, the preparation of the Medical washing fluid of 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic
Fill a prescription as follows:
Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic 0.2g
Water for injection 99.8g
Preparation method is as follows:
Take recipe quantity Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic, adds in recipe quantity water for injection, stirring and dissolving, and sterilizing, both must contain Isosorbide-5-Nitrae, the Medical washing fluid of 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic.
Embodiment 2 is containing Isosorbide-5-Nitrae, the preparation of the Medical washing fluid of 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic
Fill a prescription as follows:
Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic 0.7g
Water for injection 99.3g
Preparation method is as follows:
Take recipe quantity Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic, adds in recipe quantity water for injection, stirring and dissolving, and sterilizing, both must contain Isosorbide-5-Nitrae, the Medical washing fluid of 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic.
Embodiment 3 is containing Isosorbide-5-Nitrae, the preparation of the Medical washing fluid of 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic
Fill a prescription as follows:
Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic 1g
Water for injection 99g
Preparation method is as follows:
Take recipe quantity Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic, adds in recipe quantity water for injection, stirring and dissolving, and sterilizing, both must contain Isosorbide-5-Nitrae, the Medical washing fluid of 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic.
Embodiment 4 is containing Isosorbide-5-Nitrae, the preparation of the Medical washing fluid of 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic
Fill a prescription as follows:
Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic 1.8g
Water for injection 98.2g
Preparation method is as follows:
Take recipe quantity Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic, adds in recipe quantity water for injection, stirring and dissolving, and sterilizing, both must contain Isosorbide-5-Nitrae, the Medical washing fluid of 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic.
Embodiment 5 is containing Isosorbide-5-Nitrae, the preparation of the Medical washing fluid of 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic
Fill a prescription as follows:
Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic 4g
Water for injection 96g
Preparation method is as follows:
Take recipe quantity Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic, adds in recipe quantity water for injection, stirring and dissolving, and sterilizing, both must contain Isosorbide-5-Nitrae, the Medical washing fluid of 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic.
Embodiment 6 is containing Isosorbide-5-Nitrae, the preparation of the Medical washing fluid of 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic
Fill a prescription as follows:
Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic 7g
Water for injection 93g
Preparation method is as follows:
Take recipe quantity Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic, adds in recipe quantity water for injection, stirring and dissolving, and sterilizing, both must contain Isosorbide-5-Nitrae, the Medical washing fluid of 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic.
Embodiment 7 is containing Isosorbide-5-Nitrae, the preparation of the Medical washing fluid of 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic
Fill a prescription as follows:
Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic 9g
Water for injection 91g
Preparation method is as follows:
Take recipe quantity Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic, adds in recipe quantity water for injection, stirring and dissolving, and sterilizing, both must contain Isosorbide-5-Nitrae, the Medical washing fluid of 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic.
Embodiment 8 is containing Isosorbide-5-Nitrae, the preparation of the Medical washing fluid of 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic
Fill a prescription as follows:
Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic 12g
Water for injection 88g
Preparation method is as follows:
Take recipe quantity Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic, adds in recipe quantity water for injection, stirring and dissolving, and sterilizing, both must contain Isosorbide-5-Nitrae, the Medical washing fluid of 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic.
Embodiment 9 is containing Isosorbide-5-Nitrae, the preparation of the Medical washing fluid of 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic
Fill a prescription as follows:
Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic 20g
Water for injection 80g
Preparation method is as follows:
Take recipe quantity Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic, adds in recipe quantity water for injection, stirring and dissolving, and sterilizing, both must contain Isosorbide-5-Nitrae, the Medical washing fluid of 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic.
Embodiment 10 is containing Isosorbide-5-Nitrae, the preparation of the Medical washing fluid of 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic
Fill a prescription as follows:
Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic 26g
Water for injection 74g
Preparation method is as follows:
Take recipe quantity Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic, adds in recipe quantity water for injection, stirring and dissolving, and sterilizing, both must contain Isosorbide-5-Nitrae, the Medical washing fluid of 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic.
Embodiment 11 is containing Isosorbide-5-Nitrae, the preparation of the Medical washing fluid of 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic
Fill a prescription as follows:
Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic 28g
Water for injection 72g
Preparation method is as follows:
Take recipe quantity Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic, adds in recipe quantity water for injection, stirring and dissolving, and sterilizing, both must contain Isosorbide-5-Nitrae, the Medical washing fluid of 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic.
Embodiment 12 is containing the preparation of the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid
Fill a prescription as follows:
(S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid 0.3g
Water for injection 99.7g
Preparation method is as follows:
Take recipe quantity (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid, add in recipe quantity water for injection, stirring and dissolving, sterilizing, both must be containing the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid.
Embodiment 13 is containing the preparation of the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid
Fill a prescription as follows:
(S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid 0.8g
Water for injection 99.2g
Preparation method is as follows:
Take recipe quantity (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid, add in recipe quantity water for injection, stirring and dissolving, sterilizing, both must be containing the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid.
Embodiment 14 is containing the preparation of the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid
Fill a prescription as follows:
(S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid 1.4g
Water for injection 98.6g
Preparation method is as follows:
Take recipe quantity (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid, add in recipe quantity water for injection, stirring and dissolving, sterilizing, both must be containing the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid.
Embodiment 15 is containing the preparation of the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid
Fill a prescription as follows:
(S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid 2.6g
Water for injection 97.4g
Preparation method is as follows:
Take recipe quantity (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid, add in recipe quantity water for injection, stirring and dissolving, sterilizing, both must be containing the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid.
Embodiment 16 is containing the preparation of the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid
Fill a prescription as follows:
(S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid 3.0g
Water for injection 97g
Preparation method is as follows:
Take recipe quantity (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid, add in recipe quantity water for injection, stirring and dissolving, sterilizing, both must be containing the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid.
Embodiment 17 is containing the preparation of the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid
Fill a prescription as follows:
(S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid 4.8g
Water for injection 95.2g
Preparation method is as follows:
Take recipe quantity (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid, add in recipe quantity water for injection, stirring and dissolving, sterilizing, both must be containing the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid.
Embodiment 18 is containing the preparation of the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid
Fill a prescription as follows:
(S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid 7.2g
Water for injection 92.8g
Preparation method is as follows:
Take recipe quantity (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid, add in recipe quantity water for injection, stirring and dissolving, sterilizing, both must be containing the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid.
Embodiment 19 is containing the preparation of the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid
Fill a prescription as follows:
(S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid 8.5g
Water for injection 91.5g
Preparation method is as follows:
Take recipe quantity (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid, add in recipe quantity water for injection, stirring and dissolving, sterilizing, both must be containing the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid.
Embodiment 20 is containing the preparation of the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid
Fill a prescription as follows:
(S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid 9.0g
Water for injection 91g
Preparation method is as follows:
Take recipe quantity (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid, add in recipe quantity water for injection, stirring and dissolving, sterilizing, both must be containing the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid.
Embodiment 21 is containing the preparation of the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid
Fill a prescription as follows:
(S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid 9.4g
Water for injection 90.6g
Preparation method is as follows:
Take recipe quantity (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid, add in recipe quantity water for injection, stirring and dissolving, sterilizing, both must be containing the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid.
Embodiment 22 is containing the preparation of the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid
Fill a prescription as follows:
(S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid 15g
Water for injection 85g
Preparation method is as follows:
Take recipe quantity (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid, add in recipe quantity water for injection, stirring and dissolving, sterilizing, both must be containing the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid.
Embodiment 23 is containing the preparation of the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid
Fill a prescription as follows:
(S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid 18g
Water for injection 82g
Preparation method is as follows:
Take recipe quantity (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid, add in recipe quantity water for injection, stirring and dissolving, sterilizing, both must be containing the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid.
Embodiment 24 is containing the preparation of the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid
Fill a prescription as follows:
(S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid 22g
Water for injection 78g
Preparation method is as follows:
Take recipe quantity (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid, add in recipe quantity water for injection, stirring and dissolving, sterilizing, both must be containing the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid.
Embodiment 25 is containing the preparation of the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid
Fill a prescription as follows:
(S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid 26g
Water for injection 74g
Preparation method is as follows:
Take recipe quantity (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid, add in recipe quantity water for injection, stirring and dissolving, sterilizing, both must be containing the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid.
Embodiment 26 is containing the preparation of the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid
Fill a prescription as follows:
(S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid 28g
Water for injection 72g
Preparation method is as follows:
Take recipe quantity (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid, add in recipe quantity water for injection, stirring and dissolving, sterilizing, both must be containing the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid.
Embodiment 27 is containing the preparation of the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid
Fill a prescription as follows:
(S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid 28g
Benzalkonium bromide 10g
Water for injection 62g
Preparation method is as follows:
Take recipe quantity (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid, benzalkonium bromide, add in recipe quantity water for injection, stirring and dissolving, sterilizing, both must be containing the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid.
Embodiment 28 is containing the preparation of the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid
Fill a prescription as follows:
(S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid 20g
Potassium sorbate 5g
Water for injection 75g
Preparation method is as follows:
Take recipe quantity (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid, potassium sorbate, add in recipe quantity water for injection, stirring and dissolving, sterilizing, both must be containing the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid.
Embodiment 29 is containing the preparation of the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid
Fill a prescription as follows:
(S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid 10g
Metacresol 5g
Water for injection 85g
Preparation method is as follows:
Take recipe quantity (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid, metacresol, add in recipe quantity water for injection, stirring and dissolving, sterilizing, both must be containing the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid.
Embodiment 30 is containing Isosorbide-5-Nitrae, the preparation of the Medical washing fluid of 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic
Fill a prescription as follows:
Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic 5g
Sodium citrate 5g
Water for injection 90g
Preparation method is as follows:
Take recipe quantity Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic, sodium citrate, add in recipe quantity water for injection, stirring and dissolving, and sterilizing, both must be containing the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid.
Embodiment 31 is containing Isosorbide-5-Nitrae, the preparation of the Medical washing fluid of 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic
Fill a prescription as follows:
Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic 20g
Sodium dihydrogen phosphate 5g
Water for injection 75g
Preparation method is as follows:
Take recipe quantity Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic, sodium dihydrogen phosphate, add in recipe quantity water for injection, stirring and dissolving, and sterilizing, both must be containing the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid.
Embodiment 32 is containing Isosorbide-5-Nitrae, the preparation of the Medical washing fluid of 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic
Fill a prescription as follows:
Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic 20g
Metacresol 3g
Sodium dihydrogen phosphate 5g
Water for injection 72g
Preparation method is as follows:
Take recipe quantity Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic, metacresol, sodium dihydrogen phosphate, add in recipe quantity water for injection, stirring and dissolving, and sterilizing, both must be containing the Medical washing fluid of (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid.
Embodiment 33 Medical washing fluids reduce tissue adhesion zoopery
ICR mice, 18～30 g, male, get 40 of test mices, be divided at random 5 groups, 8 every group.0.5% pentobarbital sodium intraperitoneal injection of anesthesia.Face upward position fixing, abdominal part cropping, sterilization, cut along ventrimeson, takes out ileum; At the ileum apart from the about 2cm of ileocecum place, with hard hair brush damage ileum serous coat one circle, length l cm, take a small amount of oozing of blood as degree.Then by ileum Hui Na abdominal cavity, as follows processing gently: a, normal saline group, with 2.5mL/ normal saline flushing abdominal cavity; B, Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic+sodium chloride low concentration group, 0.5g1,4,5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic and 3g sodium chloride add after 1000mL water for injection wiring solution-forming, with solution, according to 2.5mL/ consumption, rinse abdominal cavity; C, Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic+sodium chloride high concentration group, 24g1,4,5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic and 24g sodium chloride add after 1000mL water for injection wiring solution-forming, with solution, according to 2.5mL/ consumption, rinse abdominal cavity; D, Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic low concentration group, rinses abdominal cavity with embodiment 1 solution according to 2.5mL/ consumption; E, (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid high concentration group, rinse abdominal cavity with embodiment 24 solution according to 2.5mL/ consumption.Rinse completely, reserve part flushing liquor is in intraperitoneal, and two-layered suture closes abdomen.In postoperative the 16th d, put to death animal, observe intra-abdominal adhesions situation.Adhesion grading: 0 grade, without adhesion; 1 grade, there is the slight adhesion in 1-2 place, gently draw and open; 2 grades, there is the above slight adhesion in 2 places, still can be separated, after separation, do not stay scar; 3 grades, there is many places adhesion, more difficult separation, or adhesion is few but can not be separated; 4 grades, adhesion is agglomerating, can not be separated.Experimental result sees the following form:
As seen from the above table, Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic and Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-4-pyrimidine carboxylic low concentration and the preventive effect of highly concentrated solution to tissue adhesion, be better than normal saline group and 1,4,5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic sodium chloride mixed solution group, and adhesion rate, adhesion classification, three indexs of adhesion length are all better than normal saline group and 1,4,5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic sodium chloride mixed solution group.
The developing result experiment of embodiment 34 Medical washing fluids to root pipe smear layer
Fresh 40 of the single pipe permanent teeths of pulling out, at enamelo-cemental junction place topping, retained dental root.On root of the tooth cheek-tongue direction surface, along tooth long axile, prepare groove, sample is divided into 5 groups at random, every group of 8 teeth.A, normal saline group, with 100mL/ normal saline flushing; B, Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic+sodium chloride low concentration group, 10g1,4,5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic and 8g sodium chloride add after 1000mL water for injection wiring solution-forming, with solution, according to 100mL/ consumption, rinse; C, Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic+sodium chloride high concentration group, 24g1,4,5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic and 30g sodium chloride add after 1000mL water for injection wiring solution-forming, with solution, according to 100mL/ consumption, rinse; D, (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid low concentration group, rinse according to 100mL/ consumption with embodiment 13 solution; E, Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic high concentration group, rinses according to 100mL/ consumption with embodiment 9 solution.
Each is organized after the conventional extirpation of pulp of sample, carries out root canal preparation.The root of the tooth that root canal preparation is good is split as two halves to exposed roots pipe total length along the groove of preparation in advance.Glutaraldehyde is fixed, and gradient ethanol dehydration is dry, metal spraying, scanning electron microscopic observation, and optional 3 regions, 1/3 place in the root of each specimen, observe and take a picture at high power field (* 2000) by single blind method.
Developing result evaluation criterion is as follows:
1 grade: smear layer is removed completely, detritus amount is few, open tubules;
2 grades: smear layer is few, detritus amount a little, dentinal tubule mouth is open;
3 grades: smear layer is partly removed, detritus amount is more, visible most of dentinal tubule mouth;
4 grades: smear layer exists in a large number, detritus amount is more, and dentinal tubule's mouth is few;
5 grades: a large amount of typical smear layers, dentinal tubule disappears completely.
Developing result evaluation result sees the following form:
There is upper table visible, 1,4,5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic and 1,4,5,6-tetrahydrochysene-2-methyl-4-pyrimidine carboxylic low concentration and highly concentrated solution are better than normal saline and Isosorbide-5-Nitrae to the flushing smear layer developing result of root pipe, the mixed solution of 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic and sodium chloride.
The developing result experiment of embodiment 35 Medical washing fluids to root pipe Infection in Vitro model
The foundation of root pipe Infection in Vitro model: select the full single taproot pipe Isolated Tooth of the tip of a root, after cleaning exterior of teeth, remove corona, root of the tooth is unified into full-length 10 mm.Pull out dental pulp, unobstructed pipe, 15% ethylenediaminetetraacetic acid assisting ultrasonic is swung and is washed root pipe 2min, then uses distilled water flushing 1min, the capable tip of a root sealing of Filtek P90.
E.faecalis enterococcus faecalis is inoculated in the BHI solid medium of sterilizing, in 37 ℃ of calorstats, anaerobism is cultivated 48 h.Then all pipe specimen are placed in to BHI fluid medium, sterilizing 20 min.37 ℃ of constant temperature anaerobism are cultivated 48 h, after sterilizing.Utilize ultraviolet spectrophotometer to adjust bacterial concentration, make E.faecalis bacterium liquid at the turbidity OD=0.5 Abs at wavelength 600 nm places, in super-clean bench, each root pipe specimen is injected the bacterium liquid of 200 these turbidity of μ, and in 37 ℃ of calorstats, anaerobism is cultured to 21 d.Set up root pipe Infection in Vitro model.
After modeling completes, 40 of this teeth of label taking, are divided into 5 groups at random, and 8 every group, a, normal saline group, with 100mL/ normal saline flushing; B, Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic+sodium chloride low concentration group, 0.5g1,4,5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic and 3g sodium chloride add after 1000mL water for injection wiring solution-forming, with solution, according to 100mL/ consumption, rinse; C, Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic+sodium chloride high concentration group, 35g1,4,5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic and 42g sodium chloride add after 1000mL water for injection wiring solution-forming, with solution, according to 100mL/ consumption, rinse; D, Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic low concentration group, rinses according to 100mL/ consumption with embodiment 4 solution; E, (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid high concentration group, rinse according to 100mL/ consumption with embodiment 26 solution.Washing time 3min.Before and after rinsing, all carry out count of bacteria, to evaluate developing result.The results are shown in following table:
As seen from the above table, 1,4,5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic and 1,4,5,6-tetrahydrochysene-2-methyl-4-pyrimidine carboxylic low concentration and highly concentrated solution are better than normal saline and Isosorbide-5-Nitrae to the developing result of root canal infection bacterium, the mixed solution of 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic and sodium chloride.And Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic and sodium chloride mixed solution are to Isosorbide-5-Nitrae in the developing result of root canal infection bacterium and solution, and the concentration of 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic is non-positively related relation.
Embodiment 30 Medical washing fluid peritoneal irrigation absorption experiment
SPF level Wistar rat; male; 200～220g is after pentobarbital sodium anesthesia, flat sleeping fixing; get epigastrium median incision; stomach is proposed, and the outer upset of abdomen fully exposes pancreas, with No. 4 syringe needle planes of processing upward under tail of pancreas tunicle bud thorn to ductus pancreaticus opening direction, advance successively; slowly inject 5% Bile Salts whole pancreas is evenly swelled, then with closing abdomen behind different flushing liquors flushings abdominal cavity.Flushing liquor consumption is 4mL.A, Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic+sodium chloride low concentration group, 0.5g1,4,5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic and 3g sodium chloride add 1000mL water for injection wiring solution-forming afterflush; B, Isosorbide-5-Nitrae, concentration group in 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic+sodium chloride, 5g1,4,5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic and 5 sodium chloride add 1000mL water for injection wiring solution-forming afterflush; C, Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic+sodium chloride high concentration group, 15g1,4,5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic and 30g sodium chloride add 1000mL water for injection wiring solution-forming afterflush; D, Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic low concentration group, 0.5g1,4,5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic adds 1000mL water for injection wiring solution-forming afterflush; E, 15g (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid add 1000mL water for injection wiring solution-forming afterflush.
Close after abdomen respectively at the 4th, gather rat plasma 0.1ml, add 700ng/ml cyclophosphamide inner mark solution 10 μ l, add 0.3ml methanol to mix fast after about 10s, under 4 ℃ of conditions, the centrifugal 10min of 13000r/min gets supernatant in sample injection bottle, LC-MS/MS analytic sample concentration.Chromatographic condition is as follows:
Liquid phase chromatogram condition:
Mobile phase: acetonitrile: water (0.1% formic acid)=70:30; Flow velocity: 0.8ml/min; Column temperature: 30 ℃; ZORBAX RX-C18 chromatographic column, 2.1 * 150mm, 5 μ m; ZORBAX SB-C18 pre-column: 4.6 * 12.5mm, 5 μ m.Sampling time 2.5min.
Mass spectrum condition
ESI ion source, ion source temperature: 350 ℃; Dry gas flow velocity: 10.0L/min; Atomization gas pressure: 40.0psi; Sample detection ion: 143 → 68; Electron spray cation scan pattern.
Each organizes Isosorbide-5-Nitrae in rat sample blood plasma, and the blood drug level of 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic, (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid the results are shown in following table:
As seen from the above table, isoconcentration, equal-volume flushing liquor carry out after peritoneal irrigation, Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic, 1,4,5,6-tetrahydrochysene-2-methyl-4-pyrimidine carboxylic flushing liquor absorbtivity is significantly lower than 1,4, the mixed solution of 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic and sodium chloride, and 1,4, absorbtivity and Isosorbide-5-Nitrae after 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic, sodium chloride mixed solution peritoneal irrigation, relation between 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic, sodium chloride concentration is without evident regularity.
The mucomembranous irritant test of embodiment 36 Medical washing fluids
Get 10 of healthy rabbits, be divided at random 5 groups, 2 every group, gently carry eyelid, eyes respectively splash into 2 flushing liquors to the left and right, and then gently sleep eyelid 10s.A, Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic+sodium chloride low concentration group, 0.5g1,4,5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic and 3g sodium chloride add eye drip after 1000mL water for injection wiring solution-forming; B, Isosorbide-5-Nitrae, concentration group in 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic+sodium chloride, 5g1,4,5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic and 5 sodium chloride add eye drip after 1000mL water for injection wiring solution-forming; C, Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic+sodium chloride high concentration group, 15g1,4,5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic and 30g sodium chloride add eye drip after 1000mL water for injection wiring solution-forming; D, Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic low concentration group, 0.5g1,4,5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic adds eye drip after 1000mL water for injection wiring solution-forming; E, 15g (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid add eye drip after 1000mL water for injection wiring solution-forming.
After eye drip respectively at the 10th, 30min adopts slit lamp to carry out an irritant reaction inspection.Each inspection, records the score value of eye reaction by the < < eye irritant reaction score value standard > > in < < chemicals zest, anaphylaxis and hemolytic investigative technique guideline > >.The irritant reaction score value of the cornea of each animal, iris and conjunctiva is added to obtain to total mark, the integration summation of a group, divided by number of animals, is obtained to last score value.
Experimental result sees the following form:
| A group | B group | C group | D group | E group | |
| 10min | 1.9 | 3.1 | 0.7 | 0 | 0 |
| 30min | 0.7 | 2.4 | 0.5 | 0 | 0 |
As seen from the above table, after isoconcentration, equal-volume flushing liquor eye drip, 1,4,5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic, 1,4,5,6-tetrahydrochysene-2-methyl-4-pyrimidine carboxylic flushing liquor is without mucous membrane irritation effect, Isosorbide-5-Nitrae, 5, there is certain mucous membrane irritation effect, stimulation intensity and Isosorbide-5-Nitrae in 6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic, sodium chloride mixed solution, relation between 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic, sodium chloride concentration is without evident regularity.
Claims (8)
1. at a kind of Medical washing fluid, by following component, formed:
A, (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid, Isosorbide-5-Nitrae, a kind of in 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic;
B, water for injection;
C, optional pharmaceutically acceptable antiseptic;
D, optional pharmaceutically acceptable pH adjusting agent;
(S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid, Isosorbide-5-Nitrae in described Medical washing fluid, the mass percent concentration of 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic is 0.5～30%.
2. Medical washing fluid according to claim 1, is characterized in that, described solute is Isosorbide-5-Nitrae, 5,6-tetrahydrochysene-2-methyl-5-hydroxyl-4-pyrimidine carboxylic.
3. Medical washing fluid according to claim 1, is characterized in that, described solute is (S)-2-methyl-1,4,5,6-tetra-hydro pyrimidine-4-carboxylic acid.
4. according to the Medical washing fluid described in claims 1 to 3 any one, it is characterized in that, the mass percent concentration of described solute is 0.1～10%.
5. according to the Medical washing fluid described in claim 1 to 4 any one, it is characterized in that, the mass percent concentration of described solute is 0.1～5%.
6. according to the Medical washing fluid described in claim 1 to 5 any one, it is characterized in that, the mass percent concentration of described solute is 0.1～2%.
7. according to the Medical washing fluid described in claim 1 to 6 any one, it is characterized in that, described pharmaceutically acceptable antiseptic is benzalkonium bromide.
8. according to the Medical washing fluid described in claim 1 to 7 any one, it is characterized in that, described pharmaceutically acceptable pH adjusting agent is sodium citrate.
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| CN106361764A (en) * | 2016-08-29 | 2017-02-01 | 沂水县人民医院 | Liver cancer surgical incision flushing liquid |
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|---|---|---|---|---|
| CN102210683A (en) * | 2011-04-29 | 2011-10-12 | 山东大学 | Application of tetrahydropyrimidine and derivatives thereof in preparing medicament for preventing and treating glaucoma |
| CN102247374A (en) * | 2011-04-22 | 2011-11-23 | 山东弘立医学动物实验研究有限公司 | Application of tetrahydropyrimidin and derivative thereof in preparation of medicament for treating skin wound |
| CN103271939A (en) * | 2013-06-17 | 2013-09-04 | 济南环肽医药科技有限公司 | Anti-adhesion flushing fluid for operation |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102247374A (en) * | 2011-04-22 | 2011-11-23 | 山东弘立医学动物实验研究有限公司 | Application of tetrahydropyrimidin and derivative thereof in preparation of medicament for treating skin wound |
| CN102210683A (en) * | 2011-04-29 | 2011-10-12 | 山东大学 | Application of tetrahydropyrimidine and derivatives thereof in preparing medicament for preventing and treating glaucoma |
| CN103271939A (en) * | 2013-06-17 | 2013-09-04 | 济南环肽医药科技有限公司 | Anti-adhesion flushing fluid for operation |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106361764A (en) * | 2016-08-29 | 2017-02-01 | 沂水县人民医院 | Liver cancer surgical incision flushing liquid |
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