CN104039390B

CN104039390B - There is the pulse electromagnetic field device of viscosity applicator

Info

Publication number: CN104039390B
Application number: CN201280062210.2A
Authority: CN
Inventors: 约翰·罗伯特·马丁尼兹
Original assignee: Bioelectronics Co
Current assignee: Bioelectronics Co
Priority date: 2011-10-20
Filing date: 2012-10-22
Publication date: 2017-03-08
Anticipated expiration: 2032-10-22
Also published as: AU2012325696A1; WO2013059804A1; CN104039390A; CA2852952A1; EP2768581A4; EP2768581A1

Abstract

Electromagnetic field is applied to the system of bodily tissue and technology includes self-sustaining formula and portable electromagnetic field generator, this electromagnetic field generator adheres to surface using the adhesive ingredients on applicator so that the electromagnetic field impact bodily tissue of radiation.Adhesive ingredients can include the therapeutic substance of such as rubefacient and/or one or more additive.This device includes electromagnetic field generator, and this electromagnetic field generator is couple to the antenna being arranged to radiation field.Supply coupling is to generator to provide electric power for device, and activator appliance is used for starting electromagnetic field radiation.

Description

There is the pulse electromagnetic field device of viscosity applicator

Background technology

Having shown that to injured tissue applying electromagnetic field to promote therapeutic to cure.Specifically, with sufficiently low Field intensity applies electromagnetic field of high frequency in order to avoid causing tissue heating to have shown that the healing to promotion organization is favourable.In some feelings Under condition, the effectiveness of electromagnetic field curative effect is carried by the power requirement and extended treatment persistent period reducing applied field High.

Content of the invention

Hereinafter description is related to a kind of electromagnetic field radiation instrument of the metabolic characteristicss of impact biosystem.This system and technology are permissible Cure and treatment disease for therapeutic ground promotion organization.

On the one hand, device includes pulse electromagnetic field device and applicator.Pulse electromagnetic field device includes electromagnetic field and occurs Device, it is couple to the power supply of electromagnetic field generator, is couple to electromagnetic field generator and is arranged to the single turn ring of radiation field Shape antenna, and be configured to start the activator appliance of electromagnetic field radiation.Applicator includes limiting the flexible base board of opening, by flexibility The adhesive ingredients of first surface supporting of substrate and the therapeutic substance of the first surface supporting by flexible base board.Applicator It is configured to, using adhesive ingredients, pulse electromagnetic field device is adhered to human body so that therapeutic substance contacts the first of body Part, the Part II of body is exposed to air by the opening being limited by flexible base board, and the electromagnetic field impact radiating connects Nearly body Part I and the bodily tissue of Part II.

In another general aspect, a kind of device includes pulse electromagnetic field device and applicator.Pulse electromagnetic field device includes Electromagnetic field generator, it is couple to the power supply of electromagnetic field generator, is couple to electromagnetic field generator and is arranged to electromagnetic radiation The single turn loop aerial of field, and be configured to start the activator appliance of electromagnetic field radiation.Applicator includes limiting the flexibility of opening Substrate, the adhesive ingredients being supported by the first surface of flexible base board.Applicator is configured to pulse using adhesive ingredients The part that electromagnetic field device adheres on surface so that surface is exposed to air by the opening being limited by flexible base board.Pulse The surface that electromagnetic field device adheres to may, for example, be bodily tissue (for example, human body) or is intended to be through the clothing on the surface that clings to the body Thing.

In another general aspect, a kind of external member is included pulse electromagnetic field device, applicator and is used for being incited somebody to action using applicator Pulse electromagnetic field device adheres to the description on human body.Pulse electromagnetic field device includes electromagnetic field generator, is couple to electromagnetism The power supply of field generator, it is couple to electromagnetic field generator and is arranged to the single turn loop aerial of radiation field, and quilt It is configured to start the activator appliance of the radiation of electromagnetic field.Applicator includes limiting the flexible base board of opening, by the first of flexible base board The adhesive ingredients of surface bearing, the therapeutic substance of first surface supporting by flexible base board and contact with adhesive ingredients Release liner.Description describes, using applicator, pulse electromagnetic field device is pasted human body so that therapeutic substance connects The Part I of tactile body, and the Part II of body is exposed to air by the opening being limited by flexible base board.Description Also describe how to start the radiation of electromagnetic field.The Part I close to body for the electromagnetic field impact of radiation and the body of Part II Tissue.

Another general aspect includes providing pulse electromagnetic field device and applicator.Applicator includes limiting the flexible base of opening Plate, the adhesive ingredients being supported by the first surface of flexible base board, the therapeutic substance being supported by the first surface of flexible base board And the release liner contacting with adhesive ingredients.Release liner is removed from adhesive ingredients, and is limited by flexible base board Opening be aligned with by the opening that pulse electromagnetic field device limits.Pulse electromagnetic field device props up with by the first surface of flexible base board The adhesive ingredients contact held, and pulse electromagnetic field device pastes human body by applicator so that therapeutic substance contacts The Part I of human body, and the Part II of human body is exposed to air by the opening being limited by flexible base board.Make pulse electricity The electromagnetic field of magnetic field device radiation impact human body.

Another general aspect includes providing the pulse electromagnetic field device being fixed in applicator, removes release liner from applicator In, applicator is pasted on human body, and makes pulse electromagnetic field device radiate the electromagnetic field of impact human body.Applicator limits and opens Mouthful and include by applicator first surface supporting binding agent, by applicator first surface supporting therapeutic substance with And the release liner contacting with binding agent.Therapeutic substance contacts the Part I of human body, and the Part II of human body passes through Air is exposed to by the opening that applicator limits.

Another general aspect includes for pulse electromagnetic field device and applicator being positioned proximate to human body, and pulse electromagnetic field is filled Put and pasted so that therapeutic substance contacts the Part I of human body on human body by applicator, and the Part II of human body Air is exposed to by the opening being limited by flexible base board, and makes pulse electromagnetic field device radiate the electromagnetic field of impact human body. Applicator include limit opening flexible base board, by flexible base board first surface supporting adhesive ingredients and by flexible base The therapeutic substance of the first surface supporting of plate.

Another general aspect includes for the pulse electromagnetic field device being fixed in applicator being positioned proximate to human body, will apply ointment or plaster Device pastes so that therapeutic substance contacts the Part I of human body on human body, and the Part II of human body is by flexible base board The opening limiting is exposed to air, and makes pulse electromagnetic field device radiate the electromagnetic field of impact human body.Applicator includes limiting The flexible base board of opening, the adhesive ingredients of first surface supporting by flexible base board and propped up by the first surface of flexible base board The therapeutic substance holding.

Another general aspect includes adhering on medicated clothing pulse electromagnetic field device by applicator, so that pulse electromagnetic field is filled Put radiation field, and medicated clothing is through on human body so that pulse electromagnetic field device is close to human body and the electromagnetic field that radiates Impact human body.

The embodiment of all aspects generally above can include one or more of following applicable feature.At certain In the case of a little, release liner is contacted with adhesive ingredients.Binding agent can be nontoxic and/or hypoallergenic and/or FDA is permitted Can.For example, binding agent can be pharmaceutical grade binding agent.In some cases, adhesive ingredients include therapeutic substance.Bonding Agent composition can also include one or more additive of antibacterial or microbicidal additives, hydrogel etc..In some feelings Under condition, therapeutic substance and/or one or more additive can as individual course coating on flexible substrates rather than (or one Rise) mix with adhesive ingredients.

Therapeutic substance can be local rubefacient.Rubefacient may include for example salicylate, nicotinate ester, capsaicin, Isopropanol, menthol or a combination thereof.In some cases, rubefacient includes Flos Caryophylli, Bulbus Allii, Rhizoma Zingiberis Recens, Wasabia japonic (Euterma Wasabi), mustard, Herba Urticae Cannabinae, fan change The extract of perfume, Folium Symplocoris Caudatae or a combination thereof or oil.Therapeutic substance can have analgesic characteristic, anti-inflammatory property, anesthetis characteristic Or a combination thereof.In some cases, the persistent period of electromagnetic field radiation exceedes curative effect lasting time (that is, the pulse of therapeutic substance Electromagnetic field device is after the effect of therapeutic substance loses still in operation).

On the other hand, a kind of equipment applying therapeutic electromagnetic field is disclosed, including electromagnetic field generator, this electromagnetic field is sent out Raw device is coupled with the antenna being arranged to radiation field.Power supply is coupled to generator to provide electric power for device, and swashs Device of living is used for starting the radiation of electromagnetic field.Therapy equipment is self-contained and portable, and is arranged on bodily tissue On surface so that radiation electromagnetic field impact bodily tissue.

In embodiments, power supply is less than the battery of about 10VDC.

In another embodiment, this device is the part of therapeutic delivery system.Therapeutic delivery system includes being derived from One kind of the combination of sticking patch, binder, protector, support, belt, adhesive tape, binding agent and plaster model.

On the other hand, by including power supply, antenna and electromagnetic field generator in portable and disposable packaging, and And device is pasted the technology contributing on bodily tissue for applying therapeutic electromagnetic field.Device produces electromagnetic field, this electricity Magnetic field senses alternating current in bodily tissue.In another embodiment, the average effective substantially measuring in tissue surface Less than about 1 milliwatt and peak value Effective Radiated Power density is every square centimeter less than 100 microwatts for radiant power.

Some embodiments of system as herein described and technology can provide one or more of the following advantages.Device May be adapted to life-time service.Self-contained unit can encourage the submissiveness of patient.In some embodiments, device can be direct It is placed on bodily tissue to provide electromagnetic curing to tissue.Device be such as sticking patch, binder, protector, support, plaster model or The part of the therapeutic agent delivery system of other tissue injurys support meanss.

On the other hand, disclose one kind for faradic method in bodily tissue, pass through：(1) by this paper institute State the bodily tissue that device is positioned adjacent to individuality；And (2) make device in faradic frequency in bodily tissue effectively Ongoing operation under rate and peak value Effective Radiated Power density, wherein device are with respect to individual positioning so that device is in bodily tissue Middle faradic current without with bodily tissue conductive contact.In certain embodiments, the faradic current in bodily tissue reduces Or eliminate the pain in individuality.

On the other hand, disclose the individual method for the treatment of, pass through：(1) device described herein is positioned adjacent to individuality Bodily tissue；And (2) make device in the frequency effectively causing therapeutic response in individuality and peak value Net long wave radiation work( Ongoing operation under rate density, wherein device with respect to individual positioning so that device in bodily tissue faradic current without with Bodily tissue conductive contact.

On the other hand, disclose the individual method for the treatment of, pass through：(1) provide the device comprising electromagnetic field generator； (2) device is positioned adjacent to the bodily tissue of individuality；And (3) make device effectively cause therapeutic to respond in individuality Frequency and peak value Effective Radiated Power density under ongoing operation, wherein device with respect to individual positioning so that device is in individuality Bodily tissue in faradic current without with bodily tissue conductive contact, and wherein device realizes faradic current and penetrates into So that at least 2cm depth in bodily tissue causes therapeutic to respond in bodily tissue.In certain embodiments, in body At least 3,4,5 or 6cm depth in body tissue causes therapeutic to respond.In other embodiments, 2 in bodily tissue to 3rd, 2 to 4,2 to 5,2 to 6,3 to 4,3 to 5 or 3 to 6cm depths cause therapeutic to respond.

On the other hand, disclose a kind of method for treatment, pass through：(1) provide and be selected from pulsed electromagnetic field therapy (PEMF) device of the group of equipment, transcutaneous electric nerve stimulation device and static magnetic array composition；(2) being positioned at device has from individuality Effect ground causes at the distance of therapeutic response in individuality, and wherein device is positioned at the body part selected from group consisting of Place：The outer end of ancon transverse crease, the depression in external malleolus lower edge, the lower section of clavicle side at the level of the first intercostal space, The depression of between fourth lumbar vertebra and fifth lumbar vertebra or before 1 inch to the left or to the right of its level, fibula head or bottom, kneecap Above the inner edge of bone between about 1.5 inches and radius and palmaris longuses；And device is maintained at body part and persistently has by (3) Effect causes the time of therapeutic response.

In methods described herein, bodily tissue that this device is positioned adjacent to individuality refers to be positioned to device close Individual skin (for example, in 0.5,1,2,3,4,5 or 6 inch range of skin) or contact with skin.This device can be by Encapsulation in the material, as long as and its operate in a manner described herein, be still considered neighbouring bodily tissue.The method does not need By device penetrate skin and/or to skin plaster electrode (for example, this device in the case of not to skin plaster electrode Faradic current in bodily tissue).According to the tissue that methods described herein can receive electric current include for example skin and be located at skin Tissue (for example, joint or skeleton) under skin.

Include for exemplary means used in methods described herein：Electromagnetic field generator；Couple simultaneously with generator And it is arranged to the antenna of radiation field；The power supply (for example, battery) coupling with generator；And start the radiation of electromagnetic field Activator appliance, wherein this device is self-sustaining formula and portable.Antenna is optionally included in the antenna conductor on printed circuit board. In certain embodiments, this device comprises additionally in：Annular ring around battery；And the wire around annular ring winding.Some In embodiment, annular ring has stepped cross-sections and wire is wrapped in the top of the annular ring being couple to antenna conductor with outward Side.In certain embodiments, annular ring comprises ferrite rings.In certain embodiments, annular ring comprises to isolate the circle of magnetic.

The direction that the electric current of sensing can for example parallel or perpendicular to antenna conductor in individual bodily tissue.

In some embodiments of methods described herein, frequency is 27+/- 0.5MHz (for example, 27.1MHz).

In some embodiments of methods described herein, measure at surface (for example, the individual skin) place of bodily tissue Peak value Effective Radiated Power density to be less than 100 microwatts every square centimeter.

The device using in the method alternatively comprises delivery system, for example sticking patch, binder, protector, support, belt, Adhesive tape, binding agent or plaster model.In certain embodiments, delivery system is the adhesive bandage of special purpose.

Methods described herein can comprise additionally in electromagnetic field produced by chopping.In addition, the method also includes changing arteries and veins Rush at least one of dutycycle and pulse recurrence rate of electromagnetic field.In certain embodiments, dutycycle is about 8%-10%.

In certain embodiments, individuality has the related disease of pain and therapeutic response includes reducing or elimination is individual In pain.The example of the related disease of pain includes for example drawing during tissue injury's (for example, inflammation, infection and ischemia) Pain that the pain reaction rising is associated with musculoskeletal disorders (arthralgia that for example, such as associates with arthritis, toothache and Headache) with operation the pain being associated, be related to irritable bowel syndrome pain and chest pain.

In certain embodiments, individuality has selected from adhesive capsulitis, tennis elbow, osteoarthritis, backache, multiple The disease of the group of hardening, tendon inflammation and complication of wrist composition, and therapeutic response includes reduction or elimination and disease phase The pain of association.

In certain embodiments, individuality has the disease of skeleton, joint, soft tissue or connective tissue, and therapeutic is rung Should include reducing or eliminate the inflammation in individual skeleton, joint, soft tissue or connective tissue.In certain embodiments, individual Body has the disease of skeleton, joint, soft tissue or connective tissue, and therapeutic response includes reducing or eliminates related to disease The pain of connection.

In certain embodiments, individuality has odontopathy, and therapeutic response includes reducing or eliminating being associated with disease Pain.

In certain embodiments, individuality has arhritis conditions, and therapeutic response includes reducing or eliminates and disease Associated pain.In an embodiment, disease is knee osteoarthritis, and therapeutic response includes reducing or eliminates knee Pain.

Accompanying drawing and description below are illustrated to the details of one or more embodiments.From specification and drawings And from claims, further feature and advantage will be apparent from.

Brief description

Fig. 1 is the embodiment of the therapeutic electromagnetic device illustrating part arrangement.

Fig. 2 is the embodiment of the therapeutic electromagnetic sticking patch that layering illustrates part.

Fig. 3 is the block diagram of the embodiment of therapeutic electromagnetic device.

Fig. 4 A-B illustrates the RF waveform controlling waveform and producing.

Fig. 5 A-I illustrates antenna configuration.

Fig. 6 illustrates to adhere to the annular calutron of bodily tissue.

Fig. 7 A-D illustrates the various applications of PEMF device.

Fig. 8 and 8A illustrates enhanced antenna.

Fig. 9 illustrates to place the anatomical site of therapy equipment.

Figure 10 A illustrates the PEMF device with single turn loop aerial.

Figure 10 B illustrates the applicator of the PEMF device for adhering to Figure 10 A.

Figure 10 C illustrates to adhere to the PEMF device of Figure 10 A of the applicator of Figure 10 B.

Figure 10 D illustrates to adhere to the PEMF device of Figure 10 A of human body by the applicator of Figure 10 B.

Figure 10 E is in alignment with the side view of the applicator shown in Figure 10 C above the PEMF device of Figure 10 A.

Figure 10 F illustrates the applicator of Figure 10 C contacting with the PEMF device of Figure 10 A.

Figure 10 G illustrates to adhere to the PEMF device of Figure 10 A on surface by the applicator of Figure 10 C.

Figure 10 H is shown in the PEMF device of Figure 10 A and 10B being fixed in applicator before being applied to surface.

Figure 10 I illustrates to adhere to the PEMF device of Figure 10 H on surface.

Figure 11 A illustrates the front view with the PEMF device of single turn loop aerial.

Figure 11 B illustrate to be applied to surface before Figure 11 A adhering to applicator PEMF device.

Figure 12 A illustrates the external member including PEMF device, applicator and operation instructions.

Figure 12 B illustrates the external member including the PEMF device being fixed in applicator and operation instructions.

Figure 13 A-13E is the flow chart that description PEMF device is applied to surface by applicator.

Each in figure identical reference indicates identical component.

Specific embodiment

System as herein described and technology are related to be cured, provided to disease by the therapeutic applying electromagnetic field promotion organization And prevention and treatment of diseases.This technology include offer can be applied to bodily tissue (for example, to human body) self-sustaining formula small-sized The electromagnetic field generator changed.In certain embodiments, this technology and system include disposable and portable device.

The electromagnetic field producing can sense alternating current in bodily tissue.Alternating current can stand nonlinear electrical properties (for example, diode-like rectification), and therefore produce the low frequency current potential having with impulse modulation identical time dependence.Low frequency Current potential can stimulate cell communication by for example changing the activation potential frequency of cell.Cell communication can promote inflammation to cure And reduce edema.

These technology may also provide by being pasted into meeting by the radiated element of device and being closely positioned on bodily tissue On come the method to transmit and utilize body capacitance, scene transport and the device of the urgent little space using and low weight are provided.Suffer from It is probably important that person obeys therapeutic scheme to promoting bodily tissue to cure.By providing self-sustaining formula and portable therapy equipment The submissiveness of patient can be improved.

Some or all parts of therapeutic electromagnetic energy transmission device are desirably integrated in control circuit chip so that filling Put miniaturization.This device can be attached to body parts, for the electromagnetic curing extending.By this device is embedded or hidden Ensconce in sticking patch, binder, protector, wrappage, support, plaster model or other tissue injurys support meanss and paste body or The submissiveness of patient for treatment's scheme with adhesive tape sticking on bodily tissue, can be improved.

The effectiveness of electromagnetic curing can be improved by the extended treatment persistent period.The electromagnetic radiation of lower-wattage can be by Apply the shorter application time that may need of ratio longer a period of time.Disclosed self-contained unit can may continue number The treatment cycle in week promotes patient's submissiveness.

Fig. 1 illustrates the embodiment of therapeutic electromagnetic device 26.Control circuit chip 18 can provide operation therapeutic electricity The function of magnetic device.The embodiment of control chip 18 is disclosed in association with the description of Fig. 3, and includes radio frequency (RF) generation Device.The power supply 10 directly or indirectly being coupled with control chip is used to therapeutic electromagnetic device and powers.Power supply can wrap Include battery, photovoltaic cell or electro-chemical cell.Activator appliance 12 is used for activating device.Activator appliance can include single-use or multipurpose type Switch, and can be of short duration effect or alternating action.The actuating of activator appliance can be to include by remotely or with regard to near-earth Using being embodied in various ways of pressure, light or electronic signal.Antenna 16 is used for launching electromagnetic radiation, and deflector cover 14 is permissible For electromagnetic radiation is deflected into bodily tissue.In embodiments, antenna 16 and/or deflector 14 can be in 27 ± 0.5Mhz Frequency range in tuning electromagnetic energy.Therapeutic electromagnetic device may also include syntonizing coil 20, and this syntonizing coil 20 can be used In the impedance of antenna 16 is mated with the RF signal generator in control circuit chip 18.Circuit board 22 can be used for erecting device Element, and coupling between the element of offer device in some cases.Circuit board can include rigidity or flexible material. The installation weight assembling is less than 12 grams.

In some embodiments, adhesive material 24 can be used to for therapeutic electromagnetic device to paste bodily tissue. Adhesive material 24 includes such as pharmaceutical grade binding agent.Therapeutic electromagnetic device can be using other special purposes or multiduty Therapeutic toter is pasted, and therapeutic toter includes sticking patch, binder, protector, support, belt, adhesive tape, binding agent and stone Cream model.In some embodiments, indicator 28 may be used to provide the labelling of therapeutic electromagnetic device activation.Indicator can One or more of following to include：The visual detector of such as light emitting diode (LED), lamp or electroluminescent display； The audible indicator of such as noise maker；Or the tactile indicators of such as vibrator.In embodiments, indicator can be with Electromagnetic field generator in control circuit chip 18 couples, and indicates the electromagnetic radiation existing or lacking from device.Each Plant in embodiment, indicator can be stable, interval or pulse.

Therapeutic electromagnetic device by package or can be encapsulated in easy to reduce device in encapsulating material or other potting composition It is subject to include the probability that the foreign substance of dampness, fluid, funguses, electrostatic, dirt, particulate matter and dust injures.Including such as The encapsulating material of the insulating resin of epoxy resin, polyurethane and polyester can cast the cavity of storing apparatus part to isolate, Part is simultaneously secured in place by protection.Encapsulating material can also reduce device to be easily subject to include sky air and heat, sunlight, ultraviolet light and spuious The probability of the environmental factorss injury of electromagnetic field.In some embodiments, conformal coating can be applied to device feature and To reduce the vulnerability to dampness, fluid, funguses, electrostatic, dirt, particulate matter and dust for the device in couplings.

Fig. 2 illustrates the exploded view of the embodiment of therapeutic electromagnetic device of the part having in stratified form.Activation is opened Close 206, control circuit chip 208, power supply 210, visual detector 212 and syntonizing coil 204 to may be mounted at top layer and attach To circuit board 202 to provide coupling between part.Deflection cover 218 can be stacked in below circuit board 202.Deflection cover 218 can To be to there is the material layer of high permeability or coating, be directly attached to circuit board 202.The antenna 214 of radiated electromagnetic energy can be folded Put below deflection cover 218 and be couple to circuit board 202.Deflection cover 218 can be by some from the energy that antenna 214 radiates Leave the part installed on circuit boards and deflect to bodily tissue.The shape of antenna is not limited, and some are common Shape shown in Fig. 5 A-I.Antenna can also include not with the conductor separating being electrical contact with each other.In some embodiments In, antenna can have the thickness less than 5 millimeters and the diameter less than 9 centimetres, or in other embodiments, less than 27 centimetres Length.Antenna can be incorporated in circuit board 202.

The shape of circuit board 202 and deflection cover 218 can be modified to make therapy equipment be suitable to concrete application.The thickness of device Less than 10 millimeters.In one embodiment, the adhesive material 216 of such as medical binding agent can be installed in antenna 214 So that device is adhered to bodily tissue on the bottom of lower section.Can also use and include sticking patch, binder, protector, support, belt, glue Other therapeutic toters of band, binding agent and plaster model.In some embodiments, part can be according to concrete application To select and to arrange.With reference to Fig. 6, for example, therapy equipment 600 can in the treatment use of the postoperative healing of such as eyes or mammary gland Generally annular in shape to have.In this case, annular shape limit hole 602, when device in position when, patient can be led to Cross this hole to see.

Fig. 3 is the circuitry block of an embodiment of control circuit chip 300 used in therapeutic electromagnetic device Figure.Optionally, syntonizing coil 302 can include in control circuit chip 300 or be installed separately.Control circuit chip 300 Part can be integrated into a part or can be assembled by discrete part.Control circuit chip 300 includes electromagnetic field and occurs Device 304, electromagnetic field generator 304 includes agitator 306 and driver 308.Be couple to the logic circuit 316 of generator 304 to Generator 304 provides and enables signal 312.Logic circuit can also provide LED signal 318, indicator electricity to indicator circuit 320 Road 320 can be couple to indicator (not shown) then.Logic circuit 316 can include discreet component, PLD (PLD), microprocessor or other micro controller unit (MCU).Power supply 324 can be used for supplying electric power to electromagnetic treatment apparatus. Activator appliance 326 controls electric power to flow to DC to DC transducer 328 from power supply.Activator appliance includes switching, and this switch can provide once Property activation and then maintain activation to reach persistent period of power source life.DC to DC transducer 328 to include logic circuit 316, The control chip part of electromagnetic field generator 304 and optional RF feedback circuit 314 provides electric power.RF feedback circuit is to logic circuit 316 offer RF radiation signals 330.Logic circuit can also provide LED signal 318 and to activator appliance to LED indicator circuit 326 offer locking signals 322.

Electromagnetic field generator 304 includes producing the agitator 306 of electromagnetic field, receives electromagnetic field, amplifies electromagnetic wave and to can Syntonizing coil 302 is selected to provide the drive circuit 308 of the electromagnetic wave amplifying.Syntonizing coil 302 can be used for driver 308 Impedance is mated with antenna 310, and this antenna 310 is arranged to radiate the electromagnetic energy amplifying.Agitator 306 can be arranged to 27 The electromagnetic wave including sine wave is produced under the carrier frequency of +/- 0.5 megahertz (MHz).In embodiments, electromagnetic curing device has The average effective radiant power less than about 1 milliwatt that substantially measures in tissue surface and every square centimeter less than 100 microwatts (μW/cm²) peak value Effective Radiated Power density.The electrical efficiency that average effective radiant power produces can also be more than 20%.Flat All effective powers are the power that device consumes in resistive load.Mean effective power be referred to as " peak value " power each Carrier power phase in pulse is distinguished.Peak value Effective Radiated Power density is that maximum carrier power is long-pending divided by the anchor ring of antenna, false If carrier wave is continuous rather than pulse.High-voltage generator (not shown) can be included with the intensity of Add Radial.High Voltage generator can generate less than 30VDC, and can synchronously become to allow the energy transduction between therapeutic pulse, with Just therapeutic pulse is not affected by energy transduction.Energy conversion can include for battery short duration being connected to electricity Inductive coil, and then coil is switched to diode or commutator and capacitor.Capacitor is in the voltage higher than battery Lower stored charge.When voltage on the capacitor reaches predetermined value, capacitor can be discharged into frequency generator, is controlled with producing The property treated pulse.Alternatively, it is connected to commutator and the transformator of capacitor can substitute inductive coil as kickback transformer.

Enable signal 312 to can be used for starting or eliminate the radiation of electromagnetic energy.RF feedback circuit 314 is arranged to detection to be come There is provided RF radiation signal 330 from the radiation of antenna 310RF and to logic circuit 316.Based on the level of RF radiation signal 330, patrol Collecting circuit provides LED signal 318 to enable/to disable LED indicator circuit 320, this LED indicator circuit 320 actuation indicator (not shown) simultaneously provides antenna just in the instruction of radiated electromagnetic energy.Logic circuit 316, LED indicator circuit 320 or indicator Can be disposed such that indicator continuously, intermittently or pulsed indicate.Logic circuit may also provide enabling Signal 312 is enabling/to disable electromagnetic field generator 304.

In an embodiment, the energy being radiated by antenna 310 can be pulse.PEMF device can be used for long period ground Electromagnetic field treatments are provided and reduce the heating of bodily tissue.Fig. 4 A illustrate can from logic circuit 316 provide to enable produce and The enable signal 410 of radiated electromagnetic energy.In this example, enable every millisecond of signal and go to logic high.Enabling pulse electricity Put down and be shown as logic high, but can be alternatively logic low.In some embodiments although other voltage is can Can, logic high can be power supply or normalized non-zero voltage.Shown dutycycle is about 8% to 10%.At certain In a little embodiments, electromagnetic treatment apparatus can operate in the frequency range of 3-30MHz, and the applying of electromagnetic energy can be with arteries and veins Impulsive motion is that the therapeutic effect making field maximizes.The pulse in 100 microseconds (μ S) pulse duration being spaced with 1 millisecond (mS) (pulse recurrence rate of 1000Hz) is probably preferably.In order to reduce the heating of tissue, the electromagnetic field that measures close to tissue surface Intensity can be constrained to (μ Wcm every square centimeter less than 100 microwatts^-2).Fig. 4 B illustrates the produced output letter from antenna Numbers 412.Only enabling when signal 410 is in logic high from antenna radiated electromagnetic field 414.

Referring again to Fig. 3, power supply 324 can be unidirectional current (DC), and is desirably less than about 10VDC.Power supply is permissible It is rechargeable.Rechargeable power supply can be the lithium metal hydride or lithium ion or lithium that can recharge from external source The battery of polymer technology, this external source is included close to the sine wave fields generator of antenna 310 or for by from external source Electric power noncontact senses the separate coil (not shown) in therapy equipment.In antenna or separately coil, the electric current of sensing is permissible It is rectified and is fed into rechargeable power supply as reverse current, until power supply reaches predetermined terminal voltage or skin temperature.

Power supply 324 is couple to activator appliance 326.When activator appliance activates, power supply is coupled to and can improve and regulation power supply electricity DC to the DC transducer of voltage level.From the output voltage of the regulation of DC to DC transducer 328 be supplied to logic circuit 316, Electromagnetic field generator 304 and RF feedback circuit 314.Locking signal 322 can be provided in activator appliance extremely by logic circuit 316 During few once actuating, activator appliance is locked in "ON" position.

Optionally, the additional input signal 332 for additional functional and additional output signal 334 can be by logic electricity Road 316 receives and/or provides.For example, it is possible to provide output signal to provide the labelling of the level of the voltage level of power supply 324. Output signal can start vision or audio alarm when power supply needs and changes.Output signal can be provided to provide bodily tissue The labelling of state.The dielectric constant of tissue and electrical conductivity affect the carrier frequency in device.Electrical conductivity (σ) be multiplied by angular frequency The ratio of dielectric constant (ω ε) determines the polarity of frequency change.If σ reduces more than ω ε, carrier frequency.If ω ε exceedes σ, then carrier frequency increase.Because electrical conductivity is related to pH and free ion concentration, and dielectric constant and polar molecule and cell The abundant intensity of membrane charge is relevant, therefore the biological electricity condition of tissue can by determine carrier frequency from device begin to use when The change of carrier frequency is evaluating.

Optionally, additional output signal 334 can be by strengthening the orientation in the tissue for chemistry or drug molecule The electromagnetic field of movement, to provide control, is such as used for the silver ion of infection control.Enhanced electromagnetic field can be so that guide pole The mode of property molecule movement is the method being known as dielectrophoresis heterogeneous.Alternatively, enhanced electromagnetic field can sense Electric field, the movement of this field guiding ions is known as iontophoretic method.

Input 332 can be configured to receive electromagnetic pulse persistent period, the dutycycle of the electromagnetic field for example changing generation Or the external signal of pulse recurrence rate.

Fig. 7 A-D illustrates some applications of therapeutic electromagnetic device.Fig. 7 A illustrates to paste the therapeutic electricity of the knee of people's lower limb Magnetic device 702.This device can be used for helping healing for example have the knee of crackle, hurt, sprain or pull.Fig. 7 B illustrates to paste The muscle of robot arm 712 is to help cure the therapeutic electromagnetic device 710 for example sprained, pull or hurt.Fig. 7 C illustrates to paste The therapeutic electromagnetic device 720 of such as people's abdominal part 722 of execution suction lipectomy.Fig. 7 D illustrates face 730, on face 730, Therapeutic electromagnetic device 732 is pasted onto on the left side of face to help cure the injury of such as cavity.

Fig. 8 illustrates the enhancing antenna including the wire 802 being wound around around the annular ring 804 being arranged on printed circuit board 810 Embodiment.Circle can be ferrite or the circle of magnetic, electric insulation.This circle can be arranged to around circumference supporting battery 806.Battery 806 can be secured in place keeping battery adjacent to printed circuit board 810 by retaining clip 808.Print electricity Conductor 812 on the plate of road can be arranged as the main antenna of therapeutic electromagnetic device, and can be couple to as mentioned above Electromagnetic field generator (not shown).

The annular circle of wire 802 can transmit the phase and frequency electric current consistent with main antenna 812.Wire on annular ring 802 number of turn is arranged to provides the magnetic flux bigger than main antenna 812.This winding causes the into/out annular ring of magnetic flux Outer perimeter.The part impact of (alternation) magnetic flux is sensing the therapeutic electricity of the additional alternating current concentric with main antenna Bodily tissue below magnetic device.Additional faradic current can lead to otherwise can be by having what larger-diameter main antenna produced Magnetic flux.The magnetic field line 814 of the main antenna conductor on printed circuit board can adopt the path of minimum reluctance and around printing electricity Pass through on the downside of the plate of road.Only low-intensity magnetic field impact battery 806.The major part in magnetic field can be limited near main antenna conductor.Knot Fruit is that farther place produces increased magnetic field intensity in bodily tissue.Therefore, have on the annular rings and strengthen all of sky line winding As simple or single turn loop aerial main antenna can show as the antenna with larger effective diameter.

Simple annular antenna can produce electromagnetic near field, and this electromagnetic near field can be limited in by the physical geometry of antenna In certain volume.Magnetic field on the axle of hoop antenna is weakened in proportion：

Wherein, z be with a distance from circle ring center and a be annulus radius.Exceed apart from Z, by electromagnetic field in body group The electric current knitting middle sensing may be invalid to providing therapeutic value.It is the point intersecting with this axle on the surface of this volume apart from Z Place's measurement.The treatment volume that the electromagnetic field sensing wherein in bodily tissue has therapeutic value enough can be by loop coil Radius and circularity and the electric current that flows in antennas determine.Outside this volume, treatment is possibly insufficient.In this body In long-pending, treatment is probably effectively, and gradually weakens with close to the surface for the treatment of volume.In certain embodiments, this dress Put realize faradic current be penetrated in tissue in case at least 2cm depth in bodily tissue cause therapeutic respond.

Larger effective diameter antenna can increase faradic amplitude and extend faradic penetration depth.Therefore, Have and strengthen the main antenna of antenna and can lead to merely with main antenna on bigger region in bodily tissue internal ratio and bigger depth Electric current senses.

The method skeleton treated using pulse electromagnetic field (PEMF) in specified disease and disorder of joint：There is skeleton and pass The urine of the patient of section disease generally illustrates to lead to hydroxyproline, ammonia due to the error of metabolism having an attack of one's old illness in the connective tissue of portion The level of base hexose, creatinine and alduronic acid raises.These mistakes not only can be corrected by PEMF treatment, and can subtract Minor articulus pain and swelling simultaneously improve the locomotivity in joint.PEMF treatment another major advantage be which dramatically reduces disconnected Bone cures the required time.It has also been shown that it is to osteomyelitis, osteoarthritis, rheumatic arthritis, cervical spondylosiss and low back pain (including being caused by intervertebral disk displacement) effectively.

Diabetes：By applying pulse electromagnetic field (PEMF), blood sugar level can be slowly decreased to normal or close normal. Although the mechanism of action is not fully understood, the evidence obtaining so far shows that this process not only increases the glucose in tissue Metabolism and increased the combination producing and enhancing insulin and its special receptor of insulin.It is right that this treatment also has been demonstrated Gastritis, gastric ulcer, ulcerative colitiss, allergic colitises and hemorrhoid are effective.

Bronchial asthma：Bronchial obstruction can be gradually lowered by PEMF treatment, PEMF treatment liquefaction mucus simultaneously helps In spontaneous removing.PEMF treatment also has antiinflammatory action, and this contributes to guaranteeing that air flue keeps clear and works.Accepting to control Treat patient in, forced vital capacity, forced expiratory volume and peak expiratory flow rate improve, and asthma and dyspnea notable Improve.This treatment is also effective to flu, tonsillitiss, sinusitis, chronic bronchitiss, bronchiectasis.

Cardiovascular disease：PEMF treatment is useful to the heart attack of prophylaxis of hypertension patient.Treatment contributes to reducing blood Liquid cholesterol levels simultaneously improve blood circulation by intensively adjusting vasodilation.This to prevent platelet aggregation and maintain painstaking effort Pipe is woven with the oxygen of abundance with other groups and nutrition is even more important.Atherosclerotic plaque has also been disintegrated in PEMF treatment effectively Block.The additional advantage of this process is to stop the generation of free radical, the lifting in the cardiovascular injury under cellular level of this free radical Act on.PEMF may other angiopathys be effectively phlebitis, endarteritiss and varicosis.

Brain and thinking disease：The PEMF passing through skull orientation in various location can pass through inductively in the brain Specific region produce electric current.Therefore, it is possible to improve such as study, memory by selective stimulating specific cells and can create The higher level brain function of property thinking.PEMF can have as the psychology for such as depression, aggressivity, impatience and pressure Disease and Parkinson's disease, epilepsy, migraine, the selection of apoplexy, Alzheimer's disease and other degenerative brain diseases The extensive application of therapy.In addition, stimulate by the PEMF of central nervous system to improve cerebral palsy, intellectual retardation, hyperkinetic syndrome, Practise obstacle.

PEMF treatment can improve neurochemical needed for synaptic levels transmit pulse or order for the brain cell synthesis Efficiency and by improving the electroactive of these cells.Brain is neuro chemistry compound body.The efficiency of brain or the intelligence of brain Ability depends on the efficient performance of brain cell and the generation of the referred to as chemical substance of neurotransmitters.

Too many dopamine can lead to hyperkinetic syndrome, and can lead to quadruped locomotion inharmonious (parkinson disease) very little.In brain Less acetylcholine, neurochemical be dementia, especially belong to Alzheimers type dementia the reason.As Fruit brain cell is repeatedly stimulated, and after showing suppression, brain cell rebounds and becomes more active than before stimulation.Due to PEMF has stable gene the ability of the activity of oxygen-derived free radicals preventing from being formed in cell, therefore its contribute to slowing down aging Process.

The urogenital state of an illness：PEMF is successfully used to treat menoxenia in such as woman, infertile, endometritis The urogenital state of an illness with the orchitiss in endometriosis and man, prostatitis and oligospermia.

Preoperative and prophylactic treatment：The PEMF of epigastrium treatment can be provided to body extremity increased abundant blood with Reduce the inflammatory reaction to wound.The preoperative therapy of operative segment has shown that and can accelerate to cure.

Post-operative recovery：PEMF or TENS being more than 1.5 inches above wrist line can reduce or alleviate the evil of post-operative recovery The nausea of the other forms of the heart, motion sickness or such as vomiting.

Noncontact electric current sensing in the tissue

Device as herein described can faradic current in high frequency.Become ratio the magnitude of current being sensed by device and frequency-portions Example.The pulse modulated modulation carrier waveform of the 27+/0.5Mhz (for example, 27.1MHz) such as in device described herein allows The producing ratio only bigger electric current of impulse modulation waveform in the tissue.Select to be suitable to time and the amplitude of biosystem for impulse modulation Characteristic.Carrier wave guarantees that faradic current has the amplitude being consistent in the range of impulse modulation.Different impulse modulations is by similar The faradic current of amplitude keeps.Such as pass through cell membrane, occur rectification in biosystem to cause the impulse modulation of generation Waveform is revealed as low-frequency voltage.Membrane capacitance allows faradic current to more easily enter cell than impulse modulation waveform itself.Also may be used To reduce the current distributing bypassing cell rather than passing through cell.

Faradic current claimed apparatus are non-conductive with tissue in the tissue contacts.The antenna size of much smaller device than wavelength Guarantee that transmitting is confined to area for treatment.Therefore, there is usually no the far-field radiation that can disturb such as household appliances.

Device as herein described faradic current generally under the frequency more much higher than tissue stimulation device, this tissue stimulation fills Put the capacitive stimulation device that such as pulsed coil is cured stimulator or produced impulse electric field with the vicariouss bone producing magnetic field.

The positioning of therapy equipment

The therapy equipment of such as PEMF equipment, transcutaneous electric nerve stimulation device (TENS) or static magnet array can be positioned on body Specified point on body is sentenced and is realized enhanced medical science curative effect, for example, accelerate to cure, reduce pain, swelling and injury with blood-stasis.TENS passes through Make between the electrode on skin on being placed on such as pain area for the electric current by operating.Device as herein described can be in body Faradic current in tissue and without using being applied to the electrode of skin.

Therapy equipment can position at particular acupoint and operate, and particular acupoint is including but not limited to following：Ancon tuck The outer end of trace；Depression in external malleolus lower edge；(for example, lower section is big for the lower section of the clavicle side at the level of the first intercostal space About 1 inch), between fourth lumbar vertebra and fifth lumbar vertebra；(flatly) 1 English to the left or to the right between fourth lumbar vertebra and fifth lumbar vertebra Before very little, fibula head or about 1.5 inches above the depression of bottom, the inner edge of patella；Between radius and palmaris longuses；Or The position (place the strongest of for example, keenly feeling in individuality) of pain.Fig. 9 illustrates that therapy equipment as herein described can be placed in individuality On as treatment plan (for example, reduce or eliminate pain treatment) a part anatomical site.

Therapy equipment as herein described can be combined for reducing or eliminating pain with specific acupuncture location technology.Pain phase The example of related disorders includes pain reaction and the flesh for example causing during tissue injury's (for example, inflammation, infection and ischemia) The pain (arthralgia, toothache and the headache that for example, are such as associated with arthritis) that meat bone disorders are associated is associated with operation Pain, be related to the pain of irritable bowel syndrome, and chest pain.

PEMF device described herein can be combined for reducing or eliminating pain with therapeutic substance.Therapeutic substance includes Such as local rubefacient, analgesic, anti-inflammatory agent, anesthetis or a combination thereof.Rubefacient includes but is not limited to salicylate, nicotinate Ester, capsaicin, isopropanol, menthol, be derived from Flos Caryophylli, Bulbus Allii, Rhizoma Zingiberis Recens, Wasabia japonic (Euterma Wasabi), mustard, the extract of Herba Urticae Cannabinae, Herba Rosmarini Officinalis or Folium Symplocoris Caudatae Or oil or its combination in any.Therapeutic substance can produce heat and feel or the sense of cold.In some cases, for example, it is possible to include treatment Property material combination felt and the sense of cold with the common heat that produces.For example, it is possible to include capsaicin to provide heat feel, the state of an illness can include thin Lotus alcohol is to provide the sense of cold.Electromagnetic field from PEMF device can improve effect of therapeutic substance, provide quick to user Or instant alleviation.Alleviation from therapeutic substance can be felt by the user before the alleviation from PEMF device. The curative effect lasting time of therapeutic substance can extend by using slow releasing preparation.Generally, the curative effect lasting time of PEMF device Exceed the curative effect lasting time of therapeutic substance so that PEMF device provides alleviation after therapeutic substance no longer works. In instances, therapeutic substance provides of short duration pain relief, thus mask pain before PEMF device comes into force.

Therapeutic substance can be arranged on and be arranged on the applicator of a part that low grade fever PEMF pastes human body, make Obtain therapeutic substance contact human body.As used herein, " low grade fever PEMF device " typically refers to operation under sufficiently low field intensity In order to avoid causing the PEMF device of tissue heating.In some cases, therapeutic substance can be included for gluing PEMF device In the adhesive ingredients of the part being attached to human body.Adhesive ingredients can include such as hypoallergenic, nontoxic, FDA and be permitted Can the generally known in the art pharmaceutical grade binding agent adhering to various skin types.Adhesive ingredients can include such as protecting One or more additional additive of the hydrophilic polymer of moist skin or wound surface, antibacterial or antimicrobial material etc..Parent Waterborne polymeric may, for example, be hydrogel.As used herein, " hydrogel " typically refer to hydrophilic, sometimes use water as in profit Polymer link network (for example, polyvinyl alcohol, sodium polyacrylate, acrylate polymer for the colloidal gel form of disperse medium With copolymer and other natural and synthetic polymer).

In some cases, adhesive ingredients and therapeutic substance can dividually provide (for example, in separate layer) To applicator.Can also be included such that (for example, adhesive ingredients can adhere to other layers that the mode of bodily tissue arranges Hydrogel layer).Release liner can be used for keeping the viscosity of adhesive ingredients before use.

Figure 10 A-10I, 11A-11B, 12A and 12B illustrate various schematic diagrams and the embodiment of PEMF device and applicator. PEMF device is adhered to the binding agent on the surface of such as medicated clothing or human body by the generally supporting of each applicator surface.It should be appreciated that In some cases, applicator include one or more therapeutic substance, one or more additive or both, and some In the case of, applicator can not include therapeutic substance.

Figure 10 A illustrates the PEMF device 1000 with body 1002 and single turn loop aerial 1004.PEMF device 1000 can To be low grade fever PEMF device.Single turn loop aerial 1004 limits opening 1006 and can have features designed to treat selecting of human body The size in region (for example, eyes, ancon, calf, shoulder, back etc.) and geometry (for example, square, circular, rectangle, Ellipse, rhombus, tear shape etc.).Body 1002 includes power supply 1008 and activator appliance 1010 and is arranged to radiation as this paper institute The electromagnetic field generator (not shown) of the electromagnetic field stated.

Figure 10 B illustrates applicator 1012.Applicator 1012 is shaped as covering PEMF device 1000, thus by PEMF device Adhere to surface.Applicator 1012 includes flexible base board 1014, has the first surface being coated in flexible base board as described herein Adhesive ingredients 1016.Flexible base board may, for example, be commonly known as the transparent, translucent of binder, adhesive tape or sticking patch or Opacifying polymers material.In some cases, adhesive ingredients 1016 include one or more therapeutic substance.In some feelings Under condition, adhesive ingredients 1016 and one or more therapeutic substance (for example, as different layers) or other additive (or layer) It is supplied separately into flexible base board 1014.Release liner 1018 contacts the adhesive ingredients 1016 on flexible base board 1014.

Figure 10 C illustrates to adhere to the PEMF device 1000 removing the applicator 1012 after release liner 1018.PEMF fills Put 1000 to be aligned with applicator 1012 so that flexible base board 1014 covers antenna 1004, and antenna adheres to flexible base board, and And the opening 1020 of applicator is directed at the opening 1006 of PEMF device.As used herein, " being directed at " the usual meaning is that positioning makes Obtain the first opening overlapping at least in part with the second opening.Adhesive ingredients on the flexible base board 1014 of applicator 1012 PEMF device 1000 is adhered to surface so that antenna 1004 meets the profile on surface by 1016.Therapeutic substance (if present) contacts The Part I on surface, and the Part II on surface is exposed by opening 1020.Compared with the substrate not having opening, there is opening 1020 flexible base board 1014 reduces the surface area using flexible base board and adhesive coverage.If PEMF device 1000 glues It is attached to human body, then opening 1020 allows air to reach the expose portion of human body, reduces the amount of binder with human contact and allows Skin is easier breathing.If PEMF device 100 adheres to medicated clothing, opening 1020 allows air to flow through applicator 1012 and arrive Reach in following bodily tissue.Therefore, opening 1020 improves comfortableness and the wearability of PEMF device 1000.

In some cases, activator appliance 1010 is extended antenna 1004, as shown in Figure 10 A and 10C.In other situations Under, activator appliance 1010 extends to the opening 1006 being limited by antenna 1004.Activator appliance 1010 can remove from PEMF device 1000 To start the operation of PEMF device before or after applicator 1012 application surface.Go from PEMF device 1000 in activator appliance 1010 Except afterwards, the electromagnetic field impact of radiation is close to the bodily tissue of PEMF device.Figure 10 D illustrates to adhere to people by applicator 1012 The PEMF device 1000 of body forearm is so that the Part I of body is contacted with applicator, and the Part II of body passes through opening 1020 are exposed to air.The antenna 1004 of PEMF device 1000 is contacted with the bodily tissue of forearm.

Figure 10 E illustrates to eliminate release liner, right with PEMF device 1000 before PEMF device is attached to applicator The side view of accurate applicator 1012.Figure 10 F is shown in before being applied to surface, adheres to the PEMF device of applicator 1012 1000 side view.Figure 10 G illustrates for PEMF device 1000 to adhere to the applicator 1012 on surface 1022 so that including antenna PEMF device meets this surface.As shown here, surface 1022 is relatively flat.However, surface 1022 can be bent to There is one or more size of the radius of curvature of various human body canonical dissections.In some cases (for example, in adhesive ingredients 1016 when not including therapeutic substance), surface 1022 can be inner surface or the outer surface of medicated clothing.User can be put on to be had Adhere to the medicated clothing close to the PEMF device 1000 of the medicated clothing of human body parts to be treated so that being derived from the electricity of PEMF device 1000 Magnetic radiation impacts the selected part of human body.In some cases, medicated clothing can be next to the skin or comfortable (for example, by fabric or Elastic fabric is made) so that antenna 1004 is held against or meets body.It can be beneficial that medicated clothing has less than 5mm's Thickness (for example, between 1mm to 3mm) is so that electromagnetic field radiation is easy to reach bodily tissue.

Figure 10 H illustrates to be fixed on the PEMF device 1000 of applicator 1024.Applicator 1024 includes the first flexible base board 1026 and second flexible base board 1028, each substrate limits opening.Opening can limit with by the antenna 1004 of PEMF device 1000 Fixed opening 1006 is aligned so that forming Common openings.PEMF device 1000 (for example, using binding agent) positioning (for example, Gu Determine, fasten or press from both sides) between the first flexible base board 1026 and the second flexible base board 1028.The outer surface of the first flexible base board 1026 Adhesive ingredients, therapeutic substance, one or more additive or its any combinations can be supported, as described herein.Some In the case of, as shown in Figure 10 H, applicator 1024 includes the release liner contacting with the adhesive ingredients on the first flexible base board 1026 In 1018.Release liner can remove from applicator 1024 before PEMF device 1000 adheres to surface 1022.Figure 10 I illustrates to glue It is attached to the applicator 1024 (and therefore PEMF device 1000) on surface 1022.As described herein, for being fixed in applicator PEMF device, applicator is adhered to surface and PEMF device is adhered to surface is interchangeably used.That is, applicator is glued It is attached to surface and is also understood to include and the PEMF device being fixed in applicator is adhered to surface.

Figure 11 A illustrates the PEMF device 1100 with body 1102 and single turn loop aerial 1104.PEMF device 1100 can To be low grade fever PEMF device.Single turn loop aerial 1104 limits opening 1106.Body 1102 includes power supply 1108 and activator appliance 1110, and it is arranged to the electromagnetic field generator (not shown) of radiation field, as described herein.

Figure 11 B illustrates the applicator 1112 being configured to cover PEMF device 1100.Applicator 1112 includes flexible base board 1114, there are the adhesive ingredients 1116 of the first surface being coated in flexible base board as described herein.In some cases, bond Agent composition 1116 includes one or more therapeutic substance and/or one or more additive.In some cases, binding agent becomes Points 1116 and one or more therapeutic substance or additive (for example, as different layers) be supplied separately into flexible base board 1114.Release liner can be contacted with adhesive ingredients 1116 before PEMF device 1100 adheres to applicator.In some realities Apply in example, PEMF device 1100 can be fixed between the flexible layer of applicator, as PEMF device 1000 institute in reference picture 10H State.

Figure 12 A illustrates the external member 1200 including PEMF device 1202, applicator 1204 and operation instructions 1206.Description 1206 can include PEMF device 1202 is applied to how the description on surface, such as reference picture 10A- using applicator 1204 Described in 10D.In some cases, external member 1200 includes more than one applicator 1204.In instances, external member 1200 includes four Individual applicator 1204.First applicator includes binding agent and the first therapeutic substance.Second applicator includes binding agent and second Therapeutic substance.3rd applicator includes binding agent and the combination of the first and second therapeutic substances.4th applicator includes gluing Mixture and do not have therapeutic substance.Therapeutic substance may, for example, be chosen to provide heat to feel respectively and the sense of cold capsaicin and Menthol.Therefore, user can select applicator to provide required curative effect.

Figure 12 B illustrates the external member 1210 including PEMF device 1212.PEMF device 1212 is fixed in applicator 1214.Apply The outer surface of patch device 1214 includes adhesive ingredients, as described in reference picture 10H.Adhesive ingredients can include therapeutic substance. Release liner can be contacted with adhesive ingredients.Operation instructions 1214 can be included to how by removing release liner and inciting somebody to action PEMF device 1212 is applied to retouching of surface (for example, human body) by the surface that PEMF device 1212 adheres at desired area State.

Figure 13 A-13E is description peels off the viscosity applicator of release liner by PEMF device as described herein using having The flow chart being applied to the method on surface.The feature of PEMF device and applicator describes in this reference picture 10A-10H.In some feelings Under condition, thus it is possible to vary the operation order in any one of Figure 13 A-13E, additional step can be increased, or step can be omitted. Therapeutic substance can be optionally included in adhesive ingredients or in the layer on the applicator of adhesive ingredients.

Figure 13 A is the flow chart of the method 1300 that PEMF device is applied to human body by description using viscosity applicator.? In 1302, there is provided PEMF device and applicator.Applicator includes flexible base board, as described in reference picture 10A-10H.Flexible base board Supporting adhesive ingredients and optional therapeutic substance.Release liner is contacted with adhesive ingredients.In 1304, release liner from Applicator remove (for example, peelling off) to expose adhesive ingredients, and PEMF device be positioned proximate to applicator surface make by The opening that antenna limits is aligned with the opening being limited by applicator.In 1306, PEMF device pastes human body so that binding agent Composition (with optional therapeutic substance) contacts the Part I of human body, and the Part II of human body passes through opening in applicator Mouth is exposed to air.The antenna of PEMF device is contacted with bodily tissue.In 1308, the operation starting PEMF device makes electromagnetism Field impact is close to the bodily tissue of the first and second parts of human body.

Figure 13 B is the flow chart of the method 1310 that the PEMF device being fixed in applicator is applied to human body by description.? In 1312, there is provided be fixed on the PEMF device in applicator.Applicator limits opening and has on the side of applicator Adhesive ingredients and optional therapeutic substance.Release liner is contacted with adhesive ingredients.In 1314, release liner is by from deposited Patch device removes (for example, peelling off) to expose adhesive ingredients.In 1316, applicator (and therefore PEMF device) pastes people Body is so that adhesive ingredients (with optional therapeutic substance) contact the Part I of human body, and the Part II of human body leads to The opening crossing applicator restriction is exposed to air.The antenna of PEMF device is typically secured in applicator so that it will not connect Tactile bodily tissue.In 1318, start the operation of PEMF device so that electromagnetic field impact is close to the Part I of human body and second The bodily tissue dividing.

Figure 13 C is the flow chart of the method 1320 that the PEMF device being fixed in applicator is applied to human body by description.? In 1322, release liner is removed from the applicator being couple to (for example, encase or encase at least in part) PEMF device.PEMF Device can be clipped in two of applicator between flexible layer or substrate.In 1324, applicator (and therefore PEMF device) quilt It is positioned proximate to human body.In 1326, applicator is adhered to human body so that adhesive ingredients (and optional therapeutic substance) The Part I of contact human body, and the Part II of human body is exposed to air by limiting the opening of applicator.PEMF device Antenna be fixed in applicator and bodily tissue will not be contacted.In 1328, start the operation of PEMF device so that electromagnetic field Impact is close to the Part I of human body and the bodily tissue of Part II.

Figure 13 D is the flow chart of the method 1330 that PEMF device is applied to human body by description using applicator.In 1332, Release liner is removed from applicator.In 1334, PEMF device is aligned with applicator and contacts with applicator with by PEMF Device adheres to applicator so that the opening being limited by antenna is directed at (for example, overlapping) with the opening being limited by applicator.? In 1336, using applicator, PEMF device is pasted human body so that adhesive ingredients (with optional therapeutic substance) contact The Part I of human body, and the Part II of human body is exposed to air by limiting the opening of applicator.The sky of PEMF device Linear contact lay human body.In 1338, start PEMF device operation so that electromagnetic field impact close to human body Part I and second Partial bodily tissue.

Figure 13 E is the method 1340 that the PEMF device being fixed in applicator is applied to medicated clothing by description using applicator Flow chart.In 1342, by release liner from the applicator being couple to (for example, encase or encase at least in part) PEMF device Tacky surfaces remove.In 1344, (for example, applicator (and therefore PEMF device) adheres to medicated clothing using tacky surfaces Inner surface or outer surface).Generally, the antenna of PEMF device is fixed between the layer of applicator and will not contact medicated clothing.1346, Start the operation of PEMF device.In 1348, medicated clothing is through on human body so that PEMF device is close to human body, and radiate Electromagnetic field impact human body.In some cases, PEMF device can be made with pasting medicated clothing similar to the process described in Figure 13 D PEMF device and applicator tackified surface contacts, and then, the tacky surfaces of applicator contact with the surface of medicated clothing with PEMF device is adhered to medicated clothing.In this case, the sky linear contact lay medicated clothing of PEMF device.

Other embodiment is in the scope of the following claims.

Claims

1. a kind of device cured for therapeutic ground promotion organization, including：

Pulse electromagnetic field device, described pulse electromagnetic field device includes：

Electromagnetic field generator；

Power supply, described supply coupling is to described electromagnetic field generator；

Single turn loop aerial, described single turn loop aerial is couple to described electromagnetic field generator, is arranged to radiation field；With And

Activator appliance, described activator appliance is configured to start the radiation of described electromagnetic field；

Applicator, described applicator includes：

Flexible base board, described flexible base board limits opening；

Adhesive ingredients, described adhesive composition is supported by the first surface of described flexible base board；And

Therapeutic substance, described therapeutic substance is supported by the described first surface of described flexible base board,

Wherein, described applicator is configured to, using described adhesive composition, described pulse electromagnetic field device is adhered to human body, So that：

Described therapeutic substance contacts the Part I of described human body,

The Part II of described human body is by being exposed to air by the opening that described flexible base board limits；And

The described Part I close to described human body for the electromagnetic field impact being radiated and the bodily tissue of described Part II.

2. device according to claim 1, wherein, described applicator further includes that limit the second opening second is flexible Substrate, and described antenna is fixed between described second flexible base board and the second surface of described flexible base board so that institute State the be aligned of the opening in flexible base board and described second flexible base board to form Common openings, and wherein, described applicator quilt It is configured with described adhesive composition and described pulse electromagnetic field device is adhered to described human body so that described in described human body Part II is exposed to air by described Common openings.

3. device according to claim 1, further includes release liner, described release liner and described adhesive composition Contact.

4. device according to claim 1, wherein, described adhesive composition is nontoxic.

5. device according to claim 1, further includes hydrogel, described hydrogel is by the side of described flexible base board Supporting.

6. device according to claim 5, wherein, described adhesive composition includes described hydrogel.

7. device according to claim 1, wherein, described therapeutic substance is local rubefacient.

8. device according to claim 7, wherein, described local rubefacient includes salicylate, nicotinate ester, Fructus Capsici Element, isopropanol, menthol or a combination thereof.

9. device according to claim 7, wherein, described local rubefacient include Flos Caryophylli, Bulbus Allii, Rhizoma Zingiberis Recens, Wasabia japonic (Euterma Wasabi), mustard, Herba Urticae Cannabinae, Herba Rosmarini Officinalis, the extract of Folium Symplocoris Caudatae or a combination thereof or oil.

10. device according to claim 1, wherein, described therapeutic substance has analgetic properties, anti-inflammatory property, anesthesia Characteristic or a combination thereof.

11. devices according to claim 1, wherein, described adhesive composition includes described therapeutic substance.

12. devices according to claim 1, wherein, the persistent period of described electromagnetic field radiation exceedes described therapeutic thing The curative effect lasting time of matter.

A kind of 13. external members cured for therapeutic ground promotion organization, including：

Electromagnetic field generator；

Single turn loop aerial, described single turn loop aerial is couple to described electromagnetic field generator and is arranged to electromagnetic radiation ?；And

Applicator, described applicator includes：

Flexible base board, described flexible base board limits opening；And

Adhesive ingredients and therapeutic substance, described adhesive composition and described therapeutic substance are by the first of described flexible base board Surface bearing；And

Release liner, described release liner is contacted with described adhesive composition；And

Description, described description be used for, using described applicator, described pulse electromagnetic field device is adhered to human body so that：

Described therapeutic substance contacts the Part I of described human body,

The Part II of described human body by air is exposed to by the opening that described flexible base board limits,

Start the radiation of described electromagnetic field, and

14. external members according to claim 13, wherein, described applicator further includes that limit the second opening second is soft Property substrate, and described antenna be fixed between described second flexible base board and the second surface of described flexible base board so that Opening in described flexible base board and described second flexible base board is aligned to form Common openings, and wherein, described applicator It is configured to, using described adhesive composition, described pulse electromagnetic field device is adhered to described human body so that the institute of described human body State Part II and be exposed to air by described Common openings.

A kind of 15. devices cured for therapeutic ground promotion organization, including：

Electromagnetic field generator；

Applicator, described applicator includes：

Flexible base board, described flexible base board limits opening；And

Adhesive ingredients, described adhesive composition is supported by the first surface of described flexible base board；

Wherein, described applicator is configured to, using described adhesive composition, described pulse electromagnetic field device is adhered to surface, The part making described surface is by being exposed to air by the opening that described flexible base board limits.

16. devices according to claim 15, wherein, described applicator further includes that limit the second opening second is soft Property substrate, described antenna is fixed between described second flexible base board and the second surface of described flexible base board so that described Opening be aligned in flexible base board and described second flexible base board is to form Common openings, and wherein, described applicator constructs Become and using described adhesive composition, described pulse electromagnetic field device is adhered to described surface so that described one of described surface Divide and be exposed to air by described Common openings.

17. devices according to claim 15, further include release liner, and described release liner is become with described adhesive Tap is touched.

18. devices according to claim 15, wherein, described surface is medicated clothing.

19. devices according to claim 15, wherein, described surface is bodily tissue.