CN104027513A - Green processing method for pinellia ternate - Google Patents
Green processing method for pinellia ternate Download PDFInfo
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- CN104027513A CN104027513A CN201410198447.4A CN201410198447A CN104027513A CN 104027513 A CN104027513 A CN 104027513A CN 201410198447 A CN201410198447 A CN 201410198447A CN 104027513 A CN104027513 A CN 104027513A
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Abstract
A disclosed green processing method for pinellia ternate comprises the following steps: (1) taking fresh pinellia ternate, and performing sulfur fuming processing; and (2) drying. The processing method for pinellia ternate is capable of reducing sulfur usage and even avoiding sulfur usage, is friendly to environment, green and free of pollution, helps to reduce sulfur dioxide residue in pinellia ternate, improve the safety of pinellia ternate, and has good application prospect.
Description
Technical field
The present invention relates to the processing method of the Rhizoma Pinelliae, particularly a kind of green processing method.
Background technology
The Rhizoma Pinelliae derives from the dry tuber of aroid Rhizoma Pinelliae Pinellia ternata (Thunb.) breit..China's Rhizoma Pinelliae resource distribution is extensive, and domestic except Jilin, Heilungkiang, the Inner Mongol, Xinjiang, Qinghai, Tibet, all there is distribution all the other provinces and regions.
Rhizoma Pinelliae traditional diamond-making technique adopts the mode of sulphuring more, and sulphuring method can effectively be killed antibacterial, the insect on medical material surface, accelerates rate of drying, and still, after sulphuring, in the Rhizoma Pinelliae, sulfur dioxide is residual in a large number, seriously exceedes the regulation of food hygienic standard., in the sulphuring course of processing, burn large with sulfur content meanwhile, cause environmental pollution, need to find a kind of drying means of more green non-pollution.
Summary of the invention
In order to address the above problem, the invention provides a kind of green processing method of the Rhizoma Pinelliae.
The green processing method of the Rhizoma Pinelliae of the present invention, comprises the steps:
(1) get the fresh Rhizoma Pinelliae, sulphuring;
It is (2) dry.
The time of the described sulphuring of step (1) is not higher than 6h.Preferably, the described sulphuring time is 2～6h.
Step (2) is described to be dried as drying, dry, far-infrared ray drying or drying under reduced pressure.
Described drying is to adopt natural light to dry.
The described intensity of illumination 10～1500lx drying, light application time 30min～20h/d.
The green processing method of the another kind of Rhizoma Pinelliae of the present invention, comprises the steps: to get the fresh Rhizoma Pinelliae, dries.
Described drying is to adopt natural light to dry.
The described intensity of illumination 10～1500lx drying, light application time 30min～20h/d.
The described fresh Rhizoma Pinelliae is the tuber of plant Rhizoma Pinelliae Pinellia ternata (Thunb.) breit..
The Rhizoma Pinelliae that the present invention also provides preceding method to prepare.
The processing method of the Rhizoma Pinelliae of the present invention can reduce sulfur and use, and does not even use sulfur, environmental friendliness, and green non-pollution, in the minimizing Rhizoma Pinelliae, sulfur dioxide is residual, improves its safety and has a good application prospect.
Obviously,, according to foregoing of the present invention, according to ordinary skill knowledge and the customary means of this area, not departing under the above-mentioned basic fundamental thought of the present invention prerequisite, can also make amendment, replacement or the change of other various ways.
The detailed description of the invention of form by the following examples, is described in further detail foregoing of the present invention again.But this should be interpreted as to the scope of the above-mentioned theme of the present invention only limits to following example.All technology realizing based on foregoing of the present invention all belong to scope of the present invention.
Detailed description of the invention
The green processing method of embodiment 1 Rhizoma Pinelliae of the present invention
1. instrument, reagent and reagent
UV-1100 ultraviolet-visible spectrophotometer (Shanghai Techcomp Instrument Ltd.); The accurate PH meter of PHS-3C (Shanghai Dao science and technology Instrument Ltd.), analysis to measure combination electrode (Shanghai Dao science and technology Instrument Ltd.); 85-2 temperature control magnetic stirring apparatus (Medical Instruments factory of Jintan City); BP-211D 100,000/electronic balance (German Sai Duolisi joint-stock company); RE-5203 Rotary Evaporators (Shanghai Ya Rong biochemical instrument factory); KQ-3200E type ultrasonic cleaner (Kunming ultrasonic instrument company limited); 202-2 type electric drying oven with forced convection (Shanghai experimental apparatus factory); DZF-6501 far infrared radiation drying baker, drying under reduced pressure case (Beijing Zhong Xing great achievement Instrument Ltd.).
Ephedrine hydrochloride (lot number: 0714-9903) is purchased from Nat'l Pharmaceutical & Biological Products Control Institute; Succinic acid (lot number: 896-200001) is purchased from Nat'l Pharmaceutical & Biological Products Control Institute.
Sodium carbonate standard reagent, C.I. 13020., bromocresol green, phenolphthalein are all purchased from Chengdu Ke Long chemical reagent factory; Potassium Hydrogen Phthalate (Tianjin benchmark chemical reagent company limited); Sulfur; Other agents useful for same is analytical pure.
The impact of 2 different processing methods on Rhizoma Pinelliae quality
2.1 test method
All samples is all accredited as aroid Rhizoma Pinelliae Pinellia ternata (Thunb.) Breit. through professor Li Min of Chengdu University of Traditional Chinese Medicine.After gathering, select the tuber of diameter 1cm left and right, unified peeling, clear water are cleaned, and dry respectively, dry, vacuum lyophilization, drying under reduced pressure, far-infrared ray drying and sulphuring processing; 35 DEG C, 45 DEG C, 55 DEG C, 65 DEG C and 80 DEG C of 5 temperature under drying and processing, are investigated, drying under reduced pressure has been investigated 35 DEG C, 45 DEG C, 55 DEG C 3 temperature, radiation length (10cm, 20cm, 30cm) and 9 factors of bake out temperature (35 DEG C, 45 DEG C, 55 DEG C) have been investigated in far-infrared ray drying, refer to table 1.
The processing mode of table 1 Pinellia Ternate
2.2 appearance characters and the rate of giving money as a gift
Appearance character (surface color, quality, section, gas) to the different processing methods Rhizoma Pinelliae and the rate of giving money as a gift are observed, in table 2.
Appearance character and the rate of giving money as a gift of the different processing sides of table 2 method
Brief summary: analyze knownly according to SPSS18.0 statistical software, except vacuum lyophilization, dry, dry, drying under reduced pressure, far-infrared ray drying, the dry rate of the giving money as a gift there was no significant difference (P>0.05) of sulphuring; The rate of giving money as a gift of wherein drying is slightly high, is 36.89%, and the rate of giving money as a gift of vacuum lyophilization is lower, is 19%～20%.
Dry sample surfaces yellow-white, slightly partially yellow individually, matter is solid, and mealiness is basically identical with pharmacopeia; Drying under reduced pressure person surface color is slightly partially yellow, more approaching with the description of pharmacopeia.Sulphuring Rhizoma Pinelliae surface is faint yellow solid to yellow-white, matter, and mealiness is consistent with pharmacopeia description, and on color and luster, is better than the not sulphuring Rhizoma Pinelliae.All the other samples, outside H3 (55 DEG C of oven dry) and YH2 (radiation length 20cm, 35 DEG C of oven dry), all have larger difference with the description of pharmacopeia, dry with far-infrared ray drying sample surfaces color partially deeply, and surperficial and section is keratinization.Vacuum lyophilization sample surfaces is faint yellow, but quality gently steep, section is loose, has netted aperture.
2.3 assay
Extractum to the different processing methods Rhizoma Pinelliae respectively, total alkaloids, total acid content are measured, mensuration the results are shown in Table 3.
Table 3 different processing methods Rhizoma Pinelliae extractum, alkaloid, total acid content measurement result (%, N=2)
2.4 comprehensive grading
For the quality of more scientific rational evaluation processing method, the aggregative index being formed by the appearance character of Pinellia Ternate, the rate of giving money as a gift, chemical composition content, the indexs such as Pinellia Ternate appearance character (20), the rate of giving money as a gift (6), extractum (10), total alkaloids (22), total acid (22), SO2 residual quantity (20) are weighted to scoring and analyze, in table 4.
Table 4 different processing methods Pinellia Ternate weighted scoring table
By known to the interpretation of result of different processing methods Rhizoma Pinelliae comprehensive grading, the processing mode that comprehensive grading is the highest is to dry 86.29; Next is drying under reduced pressure; Dry and there is no the residual and simple to operate of heterotoxin sulfur dioxide after sulphuring, economy, pollution-free, also suitablely carry out large batch of processing, therefore can adopt and dry in sun-drenched area.
The green processing method of embodiment 2 Rhizoma Pinelliaes of the present invention
1. instrument, reagent and reagent
UV-1100 ultraviolet-visible spectrophotometer (Shanghai Techcomp Instrument Ltd.); The accurate PH meter of PHS-3C (Shanghai Dao science and technology Instrument Ltd.), analysis to measure combination electrode (Shanghai Dao science and technology Instrument Ltd.); 85-2 temperature control magnetic stirring apparatus (Medical Instruments factory of Jintan City); BP-211D 100,000/electronic balance (German Sai Duolisi joint-stock company); RE-5203 Rotary Evaporators (Shanghai Ya Rong biochemical instrument factory); KQ-3200E type ultrasonic cleaner (Kunming ultrasonic instrument company limited); 202-2 type electric drying oven with forced convection (Shanghai experimental apparatus factory); DZF-6501 far infrared radiation drying baker, drying under reduced pressure case (Beijing Zhong Xing great achievement Instrument Ltd.).
Ephedrine hydrochloride (lot number: 0714-9903) is purchased from Nat'l Pharmaceutical & Biological Products Control Institute; Succinic acid (lot number: 896-200001) is purchased from Nat'l Pharmaceutical & Biological Products Control Institute.
Sodium carbonate standard reagent, C.I. 13020., bromocresol green, phenolphthalein are all purchased from Chengdu Ke Long chemical reagent factory; Potassium Hydrogen Phthalate (Tianjin benchmark chemical reagent company limited); Sulfur; Other agents useful for same is analytical pure.
2, the impact research of sulphuring on Rhizoma Pinelliae quality
The impact of 2.1 different sulphuring times on the Rhizoma Pinelliae
In view of drying, weather is had relatively high expectations, in the area of illumination deficiency, cannot dry immediately, if run into successive cloudy days gas, the Rhizoma Pinelliae can rot very soon, and therefore sulphuring processing still can be carried out to the Rhizoma Pinelliae in a lot of places.Show by above-mentioned experimental study, after sulphuring, the Rhizoma Pinelliae is seen outside the aspect such as feature, quality and is all met pharmacopeia requirement, but Rhizoma Pinelliae chemical composition is had a certain impact, Given this, this test to the Rhizoma Pinelliae sulphuring processing carried out the investigation of system, to set up a kind of process by sulphuring after, residual quantity is low, the Rhizoma Pinelliae green processing method of realistic need of production.
2.1.1 method
Select the Rhizoma Pinelliae tuber of diameter 1cm left and right, unified peeling, clear water are cleaned, and sulphuring is processed 2h, 4h, 6h, 8h, 10h, 12h, 24h respectively, refers to table 5.
The sulphuring processing of table 5 different time
2.1.2 appearance character and the rate of giving money as a gift
The appearance character of the different sulphuring time Rhizoma Pinelliaes and the rate of giving money as a gift are in table 6.
Appearance character and the rate of giving money as a gift of the Rhizoma Pinelliae of different sulphuring time of table 6
Brief summary: the rate of giving money as a gift of the Rhizoma Pinelliae sample of different sulphuring times is all between 31.25%～34.90%, and meansigma methods is 31.19%.Known by the analysis of SPSS18.0 statistical software, the there was no significant difference between rate (P>0.05) of giving money as a gift of different sulphuring times.Sulphuring sample surfaces is faint yellow solid to yellow-white, matter, and it is consistent that mealiness and pharmacopeia are described, and is better than the not sulphuring Rhizoma Pinelliae on color and luster, but sample after sulphuring 6h has the abnormal smells from the patient compared with strong and stimulating.
2.1.3 the mensuration of sulfur dioxide residual quantity
With reference to an annex IX U sulfur dioxide residual quantity of " Chinese Pharmacopoeia " version in 2010, method for measuring is measured, and measurement result is in table 7.
Table 7 sulfur dioxide residual quantity measurement result (ppm, N=2)
Brief summary: as shown in Table 7, the residual quantity of the Pinellia Ternate sulfur dioxide of different sulphuring time processing increases along with sulphuring time lengthening, and when sulphuring time >6h, the residual quantity of sulfur dioxide has exceeded the limitation requirement of national regulation.
2.2 impacts of different dry drying method on sulphuring Rhizoma Pinelliae sulfur dioxide residual quantity
2.2.1 method
From 3.1 result of the tests, the Rhizoma Pinelliae is at sulphuring time <6h, sulfur dioxide residual quantity is lower than 150mg/kg (ppm), on this basis, this test again different dry drying method to same sulphuring time (sulphuring 6h) (dry, dry, drying under reduced pressure, far-infrared ray drying) is investigated, and the results are shown in Table 3-6.
The same sulphuring asynchronism(-nization) of table 8 drying means
2.2.2 the mensuration of sulfur dioxide residual quantity
With reference to an annex IX U sulfur dioxide residual quantity of " Chinese Pharmacopoeia " version in 2010, method for measuring is measured.Measurement result is in table 9.
Table 9 sulfur dioxide residual quantity measurement result (ppm, N=2)
As shown in Table 9, different drying modes under the identical sulphuring time (oven dry, far-infrared ray drying, drying under reduced pressure, dry) have a certain impact to sulfur dioxide residual quantity in Pinellia Ternate, minimum with the sulfur dioxide residual quantity of ST3-1 (drying after smoked).
To sum up, known by above experimentation, in the time of Rhizoma Pinelliae preliminary working, just can keep the quality of Pinellia Ternate and the safety of medical material by controlling the sulphuring time, the mode of directly drying also can ensure quality and the safety of medical material, application prospect is good.
Claims (10)
1. a green processing method for the Rhizoma Pinelliae, is characterized in that: comprise the steps:
(1) get the fresh Rhizoma Pinelliae, sulphuring;
It is (2) dry.
2. processing method according to claim 1, is characterized in that: the time of the described sulphuring of step (1) is not higher than 6h.
3. processing method according to claim 2, is characterized in that: the described sulphuring time is 2～6h.
4. processing method according to claim 1, is characterized in that: step (2) is described to be dried as drying, dry, far-infrared ray drying or drying under reduced pressure.
5. processing method according to claim 4, is characterized in that: described in dry be adopt natural light dry.
6. processing method according to claim 4, is characterized in that: described in intensity of illumination 10～1500lx of drying, light application time 30min～20h/d.
7. a green processing method for the Rhizoma Pinelliae, is characterized in that: comprise the steps: to get the fresh Rhizoma Pinelliae, dry.
8. processing method according to claim 7, is characterized in that: described in dry be adopt natural light dry.
9. processing method according to claim 7, is characterized in that: described in intensity of illumination 10～1500lx of drying, light application time 30min～20h/d.
10. according to the processing method described in claim 1 or 7, it is characterized in that: the described fresh Rhizoma Pinelliae is the tuber of plant Rhizoma Pinelliae Pinellia ternata (Thunb.) breit..
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105535321A (en) * | 2014-10-30 | 2016-05-04 | 英山县华源农业发展有限公司 | Sulfur-free pinellia ternata processing method |
| CN111829294A (en) * | 2020-07-31 | 2020-10-27 | 贵州崖上秋歌医药科技有限公司 | Pinellia ternata drying method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102258653A (en) * | 2010-05-24 | 2011-11-30 | 成都中医药大学 | Pinellia ternata and processing method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102258653A (en) * | 2010-05-24 | 2011-11-30 | 成都中医药大学 | Pinellia ternata and processing method thereof |
Non-Patent Citations (4)
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| 国家药典委员会: "《中华人民共和国药典2010年版一部》", 31 December 2010 * |
| 康廷国: "《中药鉴定学》", 31 July 2012 * |
| 朱敏丰: ""硫熏中药材中有效成分含量变化及二氧化硫残留的研究进展"", 《海峡药学》 * |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105535321A (en) * | 2014-10-30 | 2016-05-04 | 英山县华源农业发展有限公司 | Sulfur-free pinellia ternata processing method |
| CN111829294A (en) * | 2020-07-31 | 2020-10-27 | 贵州崖上秋歌医药科技有限公司 | Pinellia ternata drying method |
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