CN104016428B - Method for processing waste water of biological pharmacy - Google Patents
Method for processing waste water of biological pharmacy Download PDFInfo
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- CN104016428B CN104016428B CN201310067018.9A CN201310067018A CN104016428B CN 104016428 B CN104016428 B CN 104016428B CN 201310067018 A CN201310067018 A CN 201310067018A CN 104016428 B CN104016428 B CN 104016428B
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Abstract
The present invention relates to a kind of method for processing waste water of biological pharmacy, mainly solve prior art and have that intermittently operated, time are long, steam energy consumption is large; Easily cause secondary pollution; The problem that sterilizing terminal can not effectively be controlled. The present invention comprises the following steps by employing: a) pass through continuously UHTS organ pipe journey containing the Wastewater in Biologic Pharmacy of active microorganism composition, obtain removing bioactive waste water; B) pass through continuously UHTS organ pipe journey containing the cleaning fluid of rotating wash bowl; C) step a) and step b) hocket, and alternating frequency has solved this problem preferably by the technical scheme of automatic controlling system, can be used for removing in bioactive industrial production containing the Wastewater in Biologic Pharmacy of active microorganism composition.
Description
Technical field
The present invention relates to a kind of method for processing waste water of biological pharmacy.
Background technology
Biological medicine technology is taking modern life science theory as basis, utilizes organism and part thereof, logicalCross the animal nutritions such as genetic engineering, cell engineering, Fermentation Engineering, enzyme engineering, research and develop and produce doctorThe complex art of medicine product. Because traditional chemical new drug development is faced with that difficulty constantly increases, cost constantly onThe situation rise, the cycle constantly extending, success rate constantly reduces, simultaneously due to the development of biotechnology with enterStep, particularly completing of the Human Genome Project, makes people that sight is progressively concerned about to biological technical field,Thereby make Bio-pharmaceutical Industry have significant progress.
Because biological medicine technology is mainly to utilize organism and part thereof, use modern biotechnologyResearch and develop and produce medicine, therefore the biological safety of production process is the emphasis that must pay close attention to. Biofermentation,In cell cultivation process, can use/or produce and there is bioactive histocyte composition, or contain biological poisonProperty material, intermediate/waste liquid that these production processes produce, must, after inactivation treatment, just can enterEnter subsequent processing/or be disposed to sewage network and do further sewage disposal. For example biological products produce in,Escherichia coli are as the host of exogenous gene expression, its efficient stable and strong adaptability, simple to operate, economyGood, be the engineering bacteria extensively adopting in genetic engineering. But due to colibacillary pathogenic stronger, route of transmissionMany (water, food, directly contact etc.), has very strong infectiousness, as caused, enteron aisle infects outward, diarrhoea etc.Therefore, have certain bioactive material for the similar Escherichia coli of employing etc., its production process must be with generalLogical environment is strictly isolated, and the waste water simultaneously giving off in its production process must pass through biodegradation/inactivation treatment,Thoroughly eliminate after its activity, just can be disposed to common sewerage, cause surrounding ring in order to avoid active component leaksThe biological pollution event in border.
The same biological products that have high pollution risk at some are as BCG vaccine, influenza vaccines, rabies vaccine etc.In production, can use some materials with bio-toxicity as have the malicious bacillus tuberculosis bovis of living, influenza virus,Rabies viruses etc. carry out inoculated and cultured and go down to posterity, to obtain immunocompetent attenuated strain. These biological productsProduction in, also use the bacterial strain with toxicant. Therefore these production processes also must strict and other districtsSeparately, the sewage of its generation also must be collected separately and after inactivation treatment, just can be disposed to common sewage in territoryTreating stations is further processed.
Hence one can see that, and in biological medicine production process, biological safety is the problem of first concern, must beEnsure, under the absolute secure prerequisite of bio-safety of production process, just can carry out the production of biological products.
In producing about biological medicine, containing the processing of viable bacteria/active-poison sewage, in engineering, generally there are two kinds of methods: changeMethod and Physical. Wherein chemical method (for example document CN101215066A) be by produced containing viable bacteria/Active-poison sewage adds chemical substance after collecting separately, is generally sodium hydroxide solution, utilizes its strong basicity feature,Protein molecule containing the malicious microorganism of viable bacteria/work is destroyed, thereby eliminate its biologically active. But this method hasLimitation, can not make all microorganisms be degraded. Another kind of mode is Physical, utilizes most of microorganism eggWhite molecule can not resistant to elevated temperatures feature, by Steam Heating waste water, thereby makes the protein denaturation of microorganismReach the object of eliminating its activity/toxicity, and safety dumping.
At present conventional containing viable bacteria/active-poison sewage heat sterilization in biological medicine industry, be discontinuous sterilizationMethod, also claims sterilization in batches. Be exactly by after special activity/the toxic waste producing in producing collection, collectingIn tank, directly pass into high-temperature steam (being generally 0.1MPa, 121 DEG C) and maintain certain hour (generally 5min～10min), make microprotein molecule in waste water solidify sex change under long-time high temperature action, thereby loseGo its intrinsic activity. Adopt its biologically active of waste water after treatment in this way and also obtained elimination.
The shortcoming of this technique is: a) intermittently operated, time are long, steam energy consumption is large; B) equipment must be withstand voltage;C), due to steam direct heating, the steam of its sterilizing generation in early stage is entrained with not the thoroughly active component of sterilizingOverflow, easily cause secondary pollution; D) due to temperature sensing point position limitation, can not ensure completely in containerAll liq has reached the sterilising temp of setting, and sterilizing terminal can not effectively be controlled.
Summary of the invention
Technical problem to be solved by this invention is that prior art exists intermittently operated, the time is long, steam energy consumption is large;Easily cause secondary pollution; The problem that sterilizing terminal can not effectively be controlled, provides a kind of new Wastewater in Biologic Pharmacy placeReason method. The method can continued operation; There is steam consumption quantity low; Sterilizing is thorough, can not cause secondary pollution;The feature that sterilizing terminal can be effectively controlled, and can realize the cleaning to pipe interior by automatic control,The operation of guarantee equipment high efficiency.
For solving the problems of the technologies described above, the technical solution used in the present invention is as follows: a kind of Wastewater in Biologic Pharmacy processingMethod, comprises the following steps:
A) pass through continuously UHTS organ pipe journey containing the Wastewater in Biologic Pharmacy of active microorganism composition, obtainRemove bioactive waste water;
B) pass through continuously UHTS organ pipe journey containing the cleaning fluid of rotating wash bowl;
C) step a) and step b) hocket, and alternating frequency is by automatic controlling system;
Wherein, described UHTS device comprises sterilizing district and heat preservation zone; Between sterilizing district and heat preservation zone, adopt cardHoop formula connects; Sterilizing district and heat preservation zone are the tubular type equipment with chuck heating.
Preferably, in the sterilizing district and heat preservation zone of described UHTS device, tube side is helix tube form.
More preferably, helix tube is stainless-steel thin-wall pipe, inner surface electropolishing, and its surface roughness Ra=0.2～0.8um; Whole helix tube adopts automatic argon arc hot melten type welding.
More preferably, the ratio d of the diameter d of described helix tube and its screw diameter D: D=1: (5～20), excellentSelect d: D=1: (8～16); The spiral step-length h of helix tube and the ratio h of the diameter d of helix tube: d=1:(1.15～5), preferably h: d=1: (1.2～4).
Preferably, inside and outside circle diameter D1, the D2 of described chuck and the diameter d of helix tube, screw diameter D itBetween relation meet: D2 > D > D1, (D2-D1) > 2d; In chuck, be provided with flow apron.
Preferably, the temperature in described sterilizing district is 101～133 DEG C, and the temperature of heat preservation zone is 100～126 DEG C;The time of staying in heat preservation zone is for being more than or equal to 1 second.
More preferably, the temperature in described sterilizing district is 105～130 DEG C, and the temperature of heat preservation zone is 105～121 DEG C;The time of staying in heat preservation zone is 3～60 seconds.
Preferably, the diameter d 2 of described rotating wash bowl is 1:(2～10 with the ratio of described helix tube diameter d).
Preferably, described rotating wash bowl is soft rotating wash bowl, and its surface roughness is 0.5～1um.
More preferably, described rotating wash bowl material is polytetrafluoroethylene (PTFE).
UHTS device in the present invention comprises sterilizing district and heat preservation zone. Waste water enters sterilizing district, at steamHeating is issued to the temperature of setting, then enters heat preservation zone, makes microprotein molecule degeneration in waste water alsoThoroughly lose activity. Discharge of wastewater after deactivation is to follow-up waste water processing station.
Because Escherichia coli are at 75 DEG C, after 15 minutes, can lose activity, salmonella is at 60 DEG C, 15 pointsAfter clock, can be killed, so sterilizing terminal can judge according to measuring sterilizing section and soaking zone drop temperature.
The sex change because microprotein molecule adds thermocoagulation, as overlong time coagulum can stick to heat exchanger tubeWall, can affect heat exchange efficiency, and therefore the structural design of heat exchanger must be considered this feature. Should increase pipeThe mobility of interior waste water, reduces the resistance of ducting, and selected heat exchanger tube inwall must be smooth smooth simultaneously, is difficult forBuildup. It is the most reasonable that tube side adopts one way form of straight lines in theory, but also can cause thus heat exchanger tube long, wholeThe shortcoming that body volume is larger. The tube side of the UHTS device in the present invention has adopted the form of helix tube, liquidUnder the identical operating path of tube side, overall volume can be effectively controlled. Solidify for reducing protein molecular in additionRear wall sticking phenomenon, tube side has adopted and has met ASMEBPE(ASME bioengineering equipment)304 stainless steel thin-wall health pipe arrangements of standard, inner surface electropolishing, its surface roughness Ra=0.2～0.8um.Whole helix tube adopts automatic argon arc hot melten type welding, and hygiene-type clamp connection, ensures the smooth seamless of inner surfaceGap. Owing to adopting helix tube mode, helix tube intermediate space is larger in addition, for reducing shell side volume, improves shellJourney steam heat-exchanging efficiency, shell side structure has adopted inside and outside circular form of sleeve.
UHTS device in the present invention is in the follow-up heat preservation zone of having set up, and protects after making waste water reach sterilising temp againHold the time of at least 1 second to thoroughly kill microorganism wherein, to ensure microprotein molecule in waste waterThoroughly deactivation, this is key point of the present invention just also.
The inventive method utilizes jacket steam to heat the waste water entering, and waste water is walked tube side, heating steamWalk shell side, heating steam does not directly contact with waste water, and the steam that can not produce sterilizing generation in early stage is entrained with notThoroughly the active component of sterilizing is overflowed, and causes the problem of secondary pollution.
UHTS device in the present invention has solved the defect of traditional handicraft, but also brought simultaneously one newPuzzlement, because the waste water that contains the bioactivators such as protein is in inactivation process, microprotein molecule addsThermocoagulation and Step denaturation, the coagulum of its generation is easy to stick on the heat exchange inwall of UHTS device,Affect the carrying out of follow-up sterilization process. As removed not in time, in laser heating situation, these protein coagulation thingsCan be attached to securely on inwall, make inwall thickening, heat transmission resistance strengthens, and circulation area reduces, and finally makesObtain UHTS device and cannot bring into play useful effect. Therefore must be removed in time. And the helix tube adopting isGuarantee sterilization effect, pipe range is longer, not easy cleaning. Conventional cleaning method is at UHTS device at presentAfter work a period of time (according to actual soil conditions, can be weekly or every ten days once), dismantled profitScrub with instrument (as soft hairbrush), but this process wastes time and energy, cleaning performance cannot ensure. At waste waterIn the high situation of microprotein content, the cleaning frequency is very short, and disassembly, cleaning meeting directly affects waste water and goes out frequentlyLive through normally carrying out of journey. The inventive method adopts rotating wash bowl to enter sterilizer tube side, utilizes bead and helix tubeThe rubbing action of inner surface, remove the protein coagulation thing on helix tube inwall in time, makes UHTS deviceHeat exchange efficiency is unaffected.
The elastic pellet that rotating wash bowl adopts high-temperature resistant rubber to make. There is decorative pattern on bead surface, and coarse injustice, to increaseAdd the friction of itself and heat exchange tube wall. The small ball's diameter d2 is 1 with the ratio of helix tube inner diameter d: (2～10). RatioToo sizes of balls is dumb at in-pipe, easily stops up, and the too little mantle friction effect of ratio is little, needs quantity phaseTo more cleaning bead. Ratio is 1 preferably: (4～8), best ratio is 1: (5～6).
In the inventive method, sterilizing and cleaning process be by automatic controlling system, sterilizing and cleaning replace intoOK, the protein molecular coagulum in time sterilization process being produced is removed from the inwall heat exchange surface of sterilizer, ensuresEquipment operates under efficient state. Wherein, cleaning frequency is relevant with the soil conditions of sterilizer heat exchange inwall,In waste water, protein content is higher, and protein molecular solidifies more, and the pollution level of heat exchanging inwall is larger, need andThe frequency of Shi Qingxi is just faster. This process can be set by automatic control system.
Adopt the inventive method to process Wastewater in Biologic Pharmacy, with traditional steam sterilization comparison at intermittence, can be continuousOperation; Operating environment is without thermal pollution, and steam consumption quantity is low, the highlyest reduces by 15～20%; Can not cause secondaryPollute; Go biologically active effect to be effectively controlled; In addition, easy to clean, effective, sterilizing and washing canCarry out continuously, obtained good technique effect.
Below by embodiment, the present invention is further elaborated.
Detailed description of the invention
[embodiment 1]
The production of human growth hormone recombinant rhGH, is taking Escherichia coli as raw material, through inoculation, cultivation, sieveThe steps such as choosing, obtain satisfactory bacterial classification, then through fermentation, separate, and freezing-thawing and cracking, extracts, separation, pureAfter change, make. Because production process has been used Escherichia coli as engineering bacteria, so production process discharge is uselessWater (comprising dosing waste water, equipment place cleaning waste water etc.) all contains Escherichia coli, has biologically active, existingAdopt heat sterilization, remove its activity.
Above-mentioned waste water is delivered to UHTS device continuously. UHTS device adopts saturated industrial steam to enterRow heating, makes microprotein solidify sex change, thereby loses its original biologically active.
In UHTS device, adopt chuck heating, the temperature in sterilizing district is 121 DEG C, and the temperature of heat preservation zone is116 DEG C; The time of staying in heat preservation zone is 10 seconds, so that microprotein molecule thoroughly solidifies sex change.
Due to after protein molecular solidifies, very easily stick on heat exchanger inner surface, thereby affect heat exchange efficiency.The heat exchanger tube of sterilizer has adopted 304 stainless steel thin-walls that meet ASMEBPE standard of inner wall smooth for this reasonHealth pipe arrangement, inner surface electropolishing, adopts automatic sub-arc sweat soldering technique, ensures that tube side inner wall smooth is seamlessGap, protein coagulation thing is difficult for adhering to. Whole tube side adopts spiral coil, cleans the motion of bead in tube sideWell, with the abundant contact friction of inside pipe wall. Per diem produce Wastewater in Biologic Pharmacy 9m3, processing 1m per hour3BiologicalWaste water, adopts 0.2MPa, and 133 DEG C of saturated industrial steams heat, and the consumption of heating steam is 188kg/h,Heat exchange area is 4m2. UHTS Qi Ge district all adopts spiral tube heat exchanger of the present invention. SpiralHeat exchanger tube is made up of 304 stainless-steel thin-wall pipes that meet ASMEBPE standard. Wherein, heat exchanger tube diameter d=40mm, its screw diameter D=400mm, d: D=1: 10, the total length L=35m of each district heat exchanger tube,The total residence time of fluid process is 160s. The pitch h=50mm of helix tube, d: h=1: 1.25, shell sideInner diameter D 1=320mm, outer diameter D 2=480mm, heat exchanger total length 1.6m. Clean the small ball's diameterd1=8mm，d1∶d=1∶5。
Automatic control system is controlled cleaning frequency, makes waste water and cleaning fluid alternately enter sterilizer, fromAnd alternately complete sterilizing/cleaning process. In the cleaning frequency, enter the spiral of sterilizer with the cleaning fluid of beadIn heat exchanger tube, by friction and the effect of impact of elastic pellet rough surface and heat exchanger tube inwall, by sterilization processThe protein coagulation thing producing is removed and is discharged with cleaning fluid from tube wall, to ensure heat exchange efficiency. Clean bead withAfter cleaning fluid goes out, enter cleaning agent storage bin, bead reclaims for next cycle. Whole heat sterilization/clearFrequency and the cycle of washing process can be according to material properties, dirt production flexible modulation. Dispose waste liquid 1 at every turnAfter hour, pass into containing the cleaning fluid 20min that cleans bead, can be by complete heat exchanger tube inner wall washing.
The inventive method can Continuous Wastewater Treatment; Operating environment is without thermal pollution; Heating steam and waste water directly do not connectTouch, can not cause secondary pollution, UHTS device can use 10 days continuously, and (80 hours) needn't aboveDisassembly, cleaning.
[embodiment 2]
With [embodiment 1], just the outlet temperature of high-temperature sterilizing chambers is 120 DEG C, and the temperature of heat-preserving equipment is120 DEG C, the time of staying in heat preservation zone is 5 seconds.
Per diem produce Wastewater in Biologic Pharmacy 9m3, processing 1m per hour3Biological wastewater, adopts 0.2MPa, 133 DEG CSaturated industrial steam heats, and the consumption of heating steam is 198kg/h, and heat exchange area is 4.0m2. OftenInferior disposing waste liquid after 45min, passes into containing the cleaning fluid 15min that cleans bead, can be by complete heat exchanger tube inner wall washingFinish.
This method can continued operation, and heating steam directly do not contact with waste water, can not cause secondary pollution,UHTS device can use 10 days continuously, and (80 hours) needn't disassembly, cleaning above.
[embodiment 3]
With [embodiment 1], the outlet temperature of high-temperature sterilizing chambers is 115 DEG C, and the temperature of heat-preserving equipment is 112 DEG C,The time of staying in heat preservation zone is 8 seconds. Just spiral heat exchange tube diameter d=25mm, its screw diameter D=300mm, d: D=1: 12, the length L=57m of each district heat exchanger tube, total residence time 100 seconds. SpiralThe pitch h=32mm of pipe, d: h=1: 1.25, shell side inner diameter D 1=250mm, outer diameter D 2=350mm,Heat exchanger total length 2.2m. Clean the small ball's diameter d1=5mm, d1: d=1: 5.
Per diem produce Wastewater in Biologic Pharmacy 9m3, processing 1m per hour3Biological wastewater, adopts 0.1MPa, 121 DEG CSaturated industrial steam heats, and the consumption of heating steam is 209kg/h, and heat exchange area is 5.4m2. At every turnDispose waste liquid after 80min, pass into containing the cleaning fluid 20min that cleans bead, can be by complete heat exchanger tube inner wall washing.
This method can continued operation, and heating steam directly do not contact with waste water, can not cause secondary pollution,UHTS device can use 10 days continuously, and (80 hours) needn't disassembly, cleaning above.
[comparative example 1]
Adopt traditional steam sterilization at intermittence, daily output Wastewater in Biologic Pharmacy 9m3. Adopt two 3m3Waste waterStorage tank, alternate run. In each storage tank, be provided with saturated vapor heating tube, 0.3MPa saturated vapor passes through DN50Jet chimney directly passes in waste water, after being heated to design temperature (110 DEG C), continues insulation operation 10min,Thoroughly solidify sex change with what ensure microprotein.
This method exists equipment investment (to need the stainless steel 3m of two withstand voltage 0.3MPa greatly3Pressure vessel), steamSteam consumption large (need consume steam 2.4t every day, increases steam consumption 20% compared with continuous processing), deactivation terminal is notEasy to control, heating steam directly contacts with waste water, easily causes the deficiency of secondary pollution.
[comparative example 2]
With [embodiment 1], just add without cleaning bead. Because protein molecular solidifies after sex change, very easily stickyBe attached to sterilizer heat exchange surface, increased the sealing factor of heat exchanger, reduced the heat exchange efficiency of heat exchanger, because ofAfter this EO, high-temperature sterilizing chambers must be dismantled every day, and manual cleaning. Because heat exchanger tube is very long,Clean inconvenience. Must be with 4% sodium hydroxide solution immersion, or the mode such as Heating Cyclic is processed. ScavengerMeasure very greatly, cleaning performance is not good.
Claims (5)
1. a method for processing waste water of biological pharmacy, comprises the following steps:
A) pass through continuously UHTS organ pipe journey containing the Wastewater in Biologic Pharmacy of active microorganism composition, obtain removing bioactive waste water;
B) pass through continuously UHTS organ pipe journey containing the cleaning fluid of rotating wash bowl;
C) step a) b) hockets with step, and alternating frequency is by automatic controlling system;
Wherein, described UHTS device comprises sterilizing district and heat preservation zone; Between sterilizing district and heat preservation zone, adopt clamping hoop type to connect; Sterilizing district and heat preservation zone are the tubular type equipment with chuck heating;
In the sterilizing district and heat preservation zone of described UHTS device, tube side is helix tube form;
The temperature in described sterilizing district is 101～133 DEG C, and the temperature of heat preservation zone is 100～126 DEG C; The time of staying in heat preservation zone is for being more than or equal to 1 second;
Described helix tube is stainless-steel thin-wall pipe, inner surface electropolishing, its surface roughness Ra=0.2～0.8um; Whole helix tube adopts automatic argon arc hot melten type welding;
Ratio d:D=1:(5～20 of the diameter d of described helix tube and its screw diameter D), the spiral step-length h of helix tube and ratio h:d=1:(1.15～5 of the diameter d of helix tube);
Relation between inside and outside circle diameter D1, the D2 of described chuck and diameter d, the screw diameter D of helix tube meets: D2 > D > D1, (D2-D1) > 2d; In chuck, be provided with flow apron.
2. method for processing waste water of biological pharmacy according to claim 1, it is characterized in that the diameter d of described helix tube and ratio d:D=1:(8～16 of its screw diameter D), the spiral step-length h of helix tube and ratio h:d=1:(1.2～4 of the diameter d of helix tube).
3. method for processing waste water of biological pharmacy according to claim 1, the temperature that it is characterized in that described sterilizing district is 105～130 DEG C, the temperature of heat preservation zone is 105～121 DEG C; The time of staying in heat preservation zone is 3～60 seconds.
4. method for processing waste water of biological pharmacy according to claim 1, is characterized in that the diameter d 2 of described rotating wash bowl and the ratio of described helix tube diameter d are 1:(2～10).
5. method for processing waste water of biological pharmacy according to claim 1, is characterized in that described rotating wash bowl is soft rotating wash bowl, and its surface roughness is 0.1～1mm.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN200981869Y (en) * | 2006-11-30 | 2007-11-28 | 中国辐射防护研究院 | Virus inactivation device |
| CN101221025A (en) * | 2008-02-04 | 2008-07-16 | 北京远东嘉创楼宇智能科技发展有限公司 | Automatic cleaning system for cleaning ball condenser |
| CN201628450U (en) * | 2009-12-31 | 2010-11-10 | 海南维瑅瑷生物工程技术有限公司 | Vacuum low-temperature dryer |
| CN102371260A (en) * | 2010-08-23 | 2012-03-14 | 葛绍忠 | Novel automatic pipeline cleaning device |
| CN202211138U (en) * | 2011-08-08 | 2012-05-09 | 上海冠生园蜂制品有限公司 | On-line osmophilic yeast killing device |
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2013
- 2013-03-01 CN CN201310067018.9A patent/CN104016428B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN200981869Y (en) * | 2006-11-30 | 2007-11-28 | 中国辐射防护研究院 | Virus inactivation device |
| CN101221025A (en) * | 2008-02-04 | 2008-07-16 | 北京远东嘉创楼宇智能科技发展有限公司 | Automatic cleaning system for cleaning ball condenser |
| CN201628450U (en) * | 2009-12-31 | 2010-11-10 | 海南维瑅瑷生物工程技术有限公司 | Vacuum low-temperature dryer |
| CN102371260A (en) * | 2010-08-23 | 2012-03-14 | 葛绍忠 | Novel automatic pipeline cleaning device |
| CN202211138U (en) * | 2011-08-08 | 2012-05-09 | 上海冠生园蜂制品有限公司 | On-line osmophilic yeast killing device |
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