CN104016428A - Method for treating biological pharmaceutical wastewater - Google Patents
Method for treating biological pharmaceutical wastewater Download PDFInfo
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- CN104016428A CN104016428A CN201310067018.9A CN201310067018A CN104016428A CN 104016428 A CN104016428 A CN 104016428A CN 201310067018 A CN201310067018 A CN 201310067018A CN 104016428 A CN104016428 A CN 104016428A
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Abstract
The invention relates to a method for treating biological pharmaceutical wastewater. The problems that the intermittent operation time is long, steam energy consumption is high, secondary pollution is easily caused and the sterilization endpoint cannot be effectively controlled in the prior art are mainly solved. The method comprises the following steps: (a) allowing biological pharmaceutical wastewater containing microbial active ingredients to continuously pass through an ultrahigh temperature sterilizer tube pass, and obtaining wastewater of which the biological activity is removed; (b) allowing a cleaning solution containing a cleaning ball to continuously pass through the ultrahigh temperature sterilizer tube pass; and (c) alternatively performing the step (a) and the step (b). According to the technical scheme that the alternate frequency is controlled by an automatic control system, the problems are well solved, and the method can be used for industrial production of the biological pharmaceutical wastewater containing microbial active ingredients, of which the biological activity is removed.
Description
Technical field
The present invention relates to a kind of method for processing waste water of biological pharmacy.
Background technology
Biological medicine technology is to take modern life science theory as basis, utilizes organism and integral part thereof, by animal nutritions such as genetically engineered, cell engineering, fermentation engineering, enzyme engineerings, researches and develops and produce the complex art of pharmaceutical prod.The situation constantly increase because traditional chemical new drug development is faced with difficulty, cost constantly rising, the cycle constantly extends, success ratio constantly reduces, while is due to development and the progress of biotechnology, particularly the Human Genome Project completes, make people that sight is progressively concerned about to biological technical field, thereby make Bio-pharmaceutical Industry have significant progress.
Because biological medicine technology is mainly to utilize organism and integral part thereof, use modern biotechnology to research and develop and produce medicine, so the biological safety of production process is the emphasis that must pay close attention to.In biological fermentation, cell cultivation process, can use/or produce and to there is bioactive histocyte composition, or the material that contains bio-toxicity, intermediate/waste liquid that these production processes produce, must be after inactivation treatment, just can enter subsequent processing/or be disposed to sewage network and do further sewage disposal.For example, in biological products are produced, intestinal bacteria are as the host of exogenous gene expression, its efficient stable and strong adaptability, and simple to operate, good economy performance, is the engineering bacteria extensively adopting in genetically engineered.But due to colibacillary pathogenic stronger, route of transmission many (water, food, directly contact etc.), has very strong infectivity, as caused, enteron aisle infects outward, diarrhoea etc.Therefore, for adopting similar intestinal bacteria etc. to there is certain bioactive material, its production process must strictly be isolated with conventional environment, the waste water simultaneously giving off in its production process must pass through biological degradation/inactivation treatment, thoroughly eliminate after its activity, just can be disposed to common sink drainage, in order to avoid activeconstituents leaks the biological pollution event that causes surrounding environment.
The biological products that equally there is high pollution risk at some as the production of bacille Calmette-Guerin vaccine, influenza vaccines, rabies vaccine etc. in, can use live as having malicious bacillus tuberculosis bovis, influenza virus, rabies virus etc. of some materials with bio-toxicity and carry out inoculation culture and go down to posterity, to obtain immunocompetent attenuated strain.In the production of these biological products, also use the bacterial strain with toxicant.Therefore these production processes also must strictly be separated with other regions, and the sewage of its generation also must be collected separately and after inactivation treatment, just can be disposed to common sewage works and further process.
Hence one can see that, and in biological medicine production process, biological safety is the problem of first concern, must, under the definitely secure prerequisite of the Biosafety that guarantees production process, just can carry out the production of biological products.
In producing about biological medicine, containing the processing of viable bacteria/active-poison sewage, in engineering, generally there are two kinds of methods: chemical method and Physical.Wherein chemical method (for example document CN101215066A) is by produced containing after the independent collection of viable bacteria/active-poison sewage, adding chemical substance, is generally sodium hydroxide solution, utilizes its strong basicity feature, protein molecule containing the malicious microorganism of viable bacteria/work is destroyed, thereby eliminate its biological activity.But this method has limitation, can not make all microorganisms be degraded.Another kind of mode is Physical, utilizes most of microbial proteinous molecule can not resistant to elevated temperatures feature, by steam heating waste water, thereby makes the protein denaturation of microorganism reach the object of eliminating its activity/toxicity, and safety dumping.
At present conventional containing viable bacteria/active-poison sewage thermal sterilization in biological medicine industry, be tyndallization, also claim sterilization in batches.Be exactly by after the special collection of the activity/toxic waste producing in producing, in holding tank, directly passing into high-temperature steam (is generally 0.1MPa, 121 ℃) and maintain certain hour (generally at 5min～10min), make microprotein molecule in waste water solidify sex change under long-time high temperature action, thereby lose its intrinsic activity.Its biological activity of waste water of adopting after processing in this way has also obtained elimination.
The shortcoming of this technique is: a) periodical operation, time are long, steam energy consumption is large; B) equipment must be withstand voltage; C), due to steam direct heating, the water vapour that its sterilizing produces is in earlier stage entrained with not the thoroughly activeconstituents of sterilizing and overflows, and easily causes secondary pollution; D) due to temperature sensing point position limitation, can not guarantee that the interior all liquid of container has reached the sterilising temp of setting completely, sterilizing terminal can not effectively be controlled.
Summary of the invention
Technical problem to be solved by this invention is that prior art exists periodical operation, the time is long, steam energy consumption is large; Easily cause secondary pollution; The problem that sterilizing terminal can not effectively be controlled, provides a kind of new method for processing waste water of biological pharmacy.The method can operate continuously; There is steam consumption quantity low; Sterilizing is thorough, can not cause secondary pollution; The feature that sterilizing terminal can be effectively controlled, and can, by automatically controlling the cleaning realizing pipe interior, guarantee equipment high efficiency operation.
For solving the problems of the technologies described above, the technical solution used in the present invention is as follows: a kind of method for processing waste water of biological pharmacy, comprises the following steps:
A) Wastewater in Biologic Pharmacy containing living microorganism composition passes through ultra high temperature sterilization (UHTS) organ pipe journey continuously, obtains removing bioactive waste water;
B) scavenging solution containing rotating wash bowl passes through ultra high temperature sterilization (UHTS) organ pipe journey continuously;
C) step a) and step b) hocket, and alternating frequency is by automatic controlling system;
Wherein, described ultra high temperature sterilization (UHTS) device comprises sterilizing district and heat preservation zone; Between sterilizing district and heat preservation zone, adopt clamping hoop type to connect; Sterilizing district and heat preservation zone are the tubular type equipment with chuck heating.
Preferably, in the sterilizing district and heat preservation zone of described ultra high temperature sterilization (UHTS) device, tube side is spiral tube form.
More preferably, spiral tube is stainless-steel thin-wall pipe, internal surface electropolishing, its surface roughness Ra=0.2～0.8um; Whole spiral tube adopts automatic argon arc hot melten type welding.
More preferably, the ratio d of the diameter d of described spiral tube and its screw diameter D: D=1: (5～20), preferably d: D=1: (8～16); The spiral step-length h of spiral tube and the ratio h of the diameter d of spiral tube: d=1: (1.15～5), preferably h: d=1: (1.2～4).
Preferably, inside and outside circle diameter D1, the D2 of described chuck and the diameter d of spiral tube, the relation between screw diameter D meet: D2>D>D1, (D2-D1) >2d; In chuck, be provided with flow apron.
Preferably, the temperature in described sterilizing district is 101～133 ℃, and the temperature of heat preservation zone is 100～126 ℃; The residence time in heat preservation zone is for being more than or equal to 1 second.
More preferably, the temperature in described sterilizing district is 105～130 ℃, and the temperature of heat preservation zone is 105～121 ℃; The residence time in heat preservation zone is 3～60 seconds.
Preferably, the diameter d 2 of described rotating wash bowl is 1:(2～10 with the ratio of described spiral tube diameter d).
Preferably, described rotating wash bowl is soft rotating wash bowl, and its surfaceness is 0.5～1um.
More preferably, described rotating wash bowl material is tetrafluoroethylene.
Ultra high temperature sterilization (UHTS) device in the present invention comprises sterilizing district and heat preservation zone.Waste water enters sterilizing district, is issued to the temperature of setting in the heating of steam, then enters heat preservation zone, makes the microbial proteinous molecule degeneration in waste water and thoroughly loses activity.Discharge of wastewater after deactivation is to follow-up waste water processing station.
Because intestinal bacteria are at 75 ℃, after 15 minutes, can lose activity, Salmonellas, at 60 ℃, can be killed after 15 minutes, so sterilizing terminal can judge according to measuring sterilizing section and holding-zone drop temperature.
The sex change because microbial proteinous molecule adds thermocoagulation, as overlong time coagulum can stick to heat exchange tube wall, can affect heat exchange efficiency, so the structure design of interchanger must be considered this feature.Should increase the mobility of the waste water in pipe, reduce the resistance of ducting, selected heat transfer tube inwall must be smooth smooth simultaneously, is difficult for buildup.It is the most reasonable that tube side adopts one way form of straight lines in theory, but also can cause thus heat transfer tube long, the shortcoming that overall volume is larger.The tube side of the ultra high temperature sterilization (UHTS) device in the present invention has adopted the form of spiral tube, and liquid is under the identical operating path of tube side, and overall volume can be effectively controlled.For reducing protein molecular, solidify rear wall sticking phenomenon in addition, tube side has adopted and has met ASME BPE(American Institute of Mechanical Engineers biotechnology equipment) 304 stainless steel thin-wall health pipe arrangements of standard, internal surface electropolishing, its surface roughness Ra=0.2～0.8um.Whole spiral tube adopts automatic argon arc hot melten type welding, and hygiene-type clamp connection, guarantees the smooth seamless of internal surface.Owing to adopting spiral tube mode, spiral tube intermediate space is larger in addition, for reducing shell side volume, improves shell side steam heat-exchanging efficiency, and shell side structure has adopted inside and outside circular form of sleeve.
Ultra high temperature sterilization (UHTS) device in the present invention is in the follow-up heat preservation zone of having set up, after making waste water reach sterilising temp, keep again the time of at least 1 second to thoroughly kill microorganism wherein, to guarantee the thorough deactivation of microbial proteinous molecule in waste water, this is key point of the present invention just also.
The inventive method utilizes jacket steam to heat the waste water entering, be that waste water is walked tube side, shell side is walked in heating steam, and heating steam does not directly contact with waste water, can not produce water vapour that sterilizing produces in earlier stage and be entrained with not the thoroughly activeconstituents of sterilizing and overflow, cause the problem of secondary pollution.
Ultra high temperature sterilization (UHTS) device in the present invention has solved the defect of traditional technology, but also brought a new puzzlement simultaneously, because the waste water that contains the biologically active substances such as protein is in inactivation process, microbial proteinous molecule adds thermocoagulation and Step denaturation, the coagulum of its generation is easy to stick on the heat exchange inwall of ultra high temperature sterilization (UHTS) device, affects the carrying out of follow-up sterilization process.As removed not in time, in laser heating situation, these protein coagulation things can be attached on inwall securely, make inwall thickening, and heat transmission resistance strengthens, and circulation area reduces, and finally makes ultra high temperature sterilization (UHTS) device cannot bring into play useful effect.Therefore must be removed in time.And the spiral tube adopting is in order to guarantee sterilising effect, pipe range is longer, not easy cleaning.At present conventional purging method be ultra high temperature sterilization (UHTS) device after work for some time (according to actual soil conditions, can be weekly or every ten days once), dismantled, utilize instrument (as soft hairbrush) to scrub, but this process wastes time and energy, cleaning performance cannot guarantee.In the situation that waste water microbial proteinous content is high, the cleaning interval is very short, and disassembly, cleaning meeting directly affects normally carrying out of waste water inactivation process frequently.The inventive method adopts rotating wash bowl to enter Sterilizers tube side, utilizes the rubbing effect of bead and spiral tube internal surface, removes in time the protein coagulation thing on spiral tube inwall, makes the heat exchange efficiency of ultra high temperature sterilization (UHTS) device unaffected.
The elastic pellet that rotating wash bowl adopts high-temperature resistant rubber to make.There is decorative pattern on bead surface, and coarse injustice, to increase the friction of itself and heat exchange tube wall.The small ball's diameter d2 is 1 with the ratio of spiral tube inner diameter d: (2～10).Ratio too sizes of balls is dumb at in-pipe, easily stops up, and the too little surface friction effect of ratio is little, needs the cleaning bead that quantity is relatively many.Ratio is 1 preferably: (4～8), best ratio is 1: (5～6).
In the inventive method, sterilizing and cleaning process are by automatic controlling system, and sterilizing and cleaning hocket, and the protein molecular coagulum in time sterilization process being produced is removed from the inwall heat exchange surface of Sterilizers, and the equipment of assurance operates under efficient state.Wherein, cleaning frequency is relevant with the soil conditions of Sterilizers heat exchange inwall, and in waste water, protein content is higher, and protein molecular solidifies more, and the pollution level of heat exchanging inwall is larger, needs the frequency of cleaning in time just faster.This process can be set by automatic control system.
Adopt the inventive method to process Wastewater in Biologic Pharmacy, with traditional steam sterilization comparison at intermittence, can operate continuously; Operating environment is without thermal pollution, and steam consumption quantity is low, the highlyest reduces by 15～20%; Can not cause secondary pollution; Go biological activity effect to be effectively controlled; In addition, easy to clean, effective, sterilizing and washing can be carried out continuously, has obtained good technique effect.
Below by embodiment, the present invention is further elaborated.
Embodiment
[embodiment 1]
The production of recombinant human somatropin rhGH, is to take intestinal bacteria as raw material, through steps such as inoculation, cultivation, screenings, obtains satisfactory bacterial classification, then through fermentation, separation, freezing-thawing and cracking, extracts, and after separation, purifying, makes.Because production process has been used intestinal bacteria as engineering bacteria, so the waste water (comprising dosing waste water, equipment place Cleaning Wastewater etc.) that production process is discharged all contains intestinal bacteria, there is biological activity, now adopt thermal sterilization, remove its activity.
Above-mentioned waste water is delivered to ultra high temperature sterilization (UHTS) device continuously.Ultra high temperature sterilization (UHTS) device adopts saturated industrial steam to heat, and makes microprotein solidify sex change, thereby loses its original biological activity.
In ultra high temperature sterilization (UHTS) device, adopt chuck heating, the temperature in sterilizing district is 121 ℃, and the temperature of heat preservation zone is 116 ℃; The residence time in heat preservation zone is 10 seconds, so that microbial proteinous molecule thoroughly solidifies sex change.
Due to after protein molecular solidifies, very easily stick on interchanger internal surface, thereby affect heat exchange efficiency.The heat transfer tube of Sterilizers has adopted the 304 stainless steel thin-wall health pipe arrangements that meet ASME BPE standard of inner wall smooth for this reason, and internal surface electropolishing adopts automatic sub-arc sweating soldering technique, guarantees that tube side inner wall smooth is seamless, and protein coagulation thing is difficult for adhering to.Whole tube side adopts spiral coil, and the motion of cleaning bead in tube side is good, with the abundant contact friction of inside pipe wall.Per diem produce Wastewater in Biologic Pharmacy 9m
3, processing 1m per hour
3biological wastewater, adopts 0.2MPa, and 133 ℃ of saturated industrial steams heat, and the consumption of heating steam is 188kg/h, and heat interchanging area is 4m
2.Ultra high temperature sterilization (UHTS) Qi Ge district all adopts spiral tube heat exchanger of the present invention.Spiral heat exchange tube is comprised of 304 stainless-steel thin-wall pipes that meet ASME BPE standard.Wherein, heat transfer tube diameter d=40mm, its screw diameter D=400mm, d: D=1: 10, the total length L=35m of each district's heat transfer tube, the total residence time of fluid process is 160s.The pitch h=50mm of spiral tube, d: h=1: 1.25, shell side inside diameter D 1=320mm, outer diameter D 2=480mm, interchanger total length 1.6m.Clean the small ball's diameter d1=8mm, d1: d=1: 5.
Automatic control system is controlled cleaning frequency, makes waste water and scavenging solution alternately enter Sterilizers, thereby alternately completes sterilizing/cleaning process.In the cleaning interval, scavenging solution with bead enters in the spiral heat exchange tube of Sterilizers, by friction and the effect of impact of elastic pellet uneven surface and heat transfer tube inwall, the protein coagulation thing that sterilization process is produced is removed and is discharged with scavenging solution from tube wall, to guarantee heat exchange efficiency.After cleaning bead and scavenging solution go out, enter cleaning agent storage bin, bead reclaims for next cycle.The frequency of whole heat sterilization/cleaning process and cycle can be according to material properties, dirt production flexible.After disposing waste liquid 1 hour, pass into containing the scavenging solution 20min that cleans bead at every turn, can heat transfer tube inner wall washing is complete.
The inventive method can Continuous Wastewater Treatment; Operating environment is without thermal pollution; Heating steam does not directly contact with waste water, can not cause secondary pollution, and ultra high temperature sterilization (UHTS) device can use 10 days continuously, and (80 hours) needn't disassembly, cleaning above.
[embodiment 2]
With [embodiment 1], just the temperature out of high-temperature sterilizing chambers is 120 ℃, and the temperature of heat-preserving equipment is 120 ℃, and the residence time in heat preservation zone is 5 seconds.
Per diem produce Wastewater in Biologic Pharmacy 9m
3, processing 1m per hour
3biological wastewater, adopts 0.2MPa, and 133 ℃ of saturated industrial steams heat, and the consumption of heating steam is 198kg/h, and heat interchanging area is 4.0m
2.Dispose waste liquid after 45min at every turn, pass into containing the scavenging solution 15min that cleans bead, can heat transfer tube inner wall washing is complete.
Present method can operate continuously, and heating steam directly do not contact with waste water, can not cause secondary pollution, and ultra high temperature sterilization (UHTS) device can use 10 days above (80 hours) needn't disassembly, cleaning continuously.
[embodiment 3]
With [embodiment 1], the temperature out of high-temperature sterilizing chambers is 115 ℃, and the temperature of heat-preserving equipment is 112 ℃, and the residence time in heat preservation zone is 8 seconds.Be spiral heat exchange tube diameter d=25mm, its screw diameter D=300mm, d: D=1: 12, the length L=57m of each district's heat transfer tube, total residence time 100 seconds.The pitch h=32mm of spiral tube, d: h=1: 1.25, shell side inside diameter D 1=250mm, outer diameter D 2=350mm, interchanger total length 2.2m.Clean the small ball's diameter d1=5mm, d1: d=1: 5.
Per diem produce Wastewater in Biologic Pharmacy 9m
3, processing 1m per hour
3biological wastewater, adopts 0.1MPa, and 121 ℃ of saturated industrial steams heat, and the consumption of heating steam is 209kg/h, and heat interchanging area is 5.4m
2.Dispose waste liquid after 80min at every turn, pass into containing the scavenging solution 20min that cleans bead, can heat transfer tube inner wall washing is complete.
Present method can operate continuously, and heating steam directly do not contact with waste water, can not cause secondary pollution, and ultra high temperature sterilization (UHTS) device can use 10 days above (80 hours) needn't disassembly, cleaning continuously.
[comparative example 1]
Adopt traditional steam sterilization at intermittence, daily output Wastewater in Biologic Pharmacy 9m
3.Adopt two 3m
3wastewater storage tank, alternate run.In each storage tank, be provided with saturation steam heating tube, 0.3MPa saturation steam directly passes in waste water by DN50 steam-pipe, after being heated to design temperature (110 ℃), continues insulation operation 10min, with what guarantee microbial proteinous, thoroughly solidifies sex change.
Present method exists facility investment (to need the stainless steel 3m of two withstand voltage 0.3MPa greatly
3pressurized vessel), steam consumption quantity large (need consume steam 2.4t every day, increases steam consumption 20% compared with continuous processing), deactivation terminal is wayward, and heating steam directly contacts with waste water, easily causes the deficiency of secondary pollution.
[comparative example 2]
With [embodiment 1], just without cleaning bead, add.Because protein molecular solidifies after sex change, very easily stick to Sterilizers heat exchange surface, increased the scale coefficient of interchanger, reduced the heat exchange efficiency of interchanger, so after every day EO, high-temperature sterilizing chambers must have been dismantled, and manual cleaning.Because heat transfer tube is very long, clean inconvenience.Must be with 4% sodium hydroxide solution immersion, or the mode such as heating cycle is processed.Cleaning amount is very large, and cleaning performance is not good.
Claims (10)
1. a method for processing waste water of biological pharmacy, comprises the following steps:
A) Wastewater in Biologic Pharmacy containing living microorganism composition passes through ultra high temperature sterilization (UHTS) organ pipe journey continuously, obtains removing bioactive waste water;
B) scavenging solution containing rotating wash bowl passes through ultra high temperature sterilization (UHTS) organ pipe journey continuously;
C) step a) and step b) hocket, and alternating frequency is by automatic controlling system;
Wherein, described ultra high temperature sterilization (UHTS) device comprises sterilizing district and heat preservation zone; Between sterilizing district and heat preservation zone, adopt clamping hoop type to connect; Sterilizing district and heat preservation zone are the tubular type equipment with chuck heating.
2. method for processing waste water of biological pharmacy according to claim 1, is characterized in that in the sterilizing district and heat preservation zone of described ultra high temperature sterilization (UHTS) device, tube side is spiral tube form.
3. method for processing waste water of biological pharmacy according to claim 2, is characterized in that described spiral tube is stainless-steel thin-wall pipe, internal surface electropolishing, its surface roughness Ra=0.2～0.8um; Whole spiral tube adopts automatic argon arc hot melten type welding.
4. method for processing waste water of biological pharmacy according to claim 2, it is characterized in that the diameter d of described spiral tube and the ratio d of its screw diameter D: D=1: (5～20), the spiral step-length h of spiral tube and the ratio h of the diameter d of spiral tube: d=1: (1.15～5).
5. method for processing waste water of biological pharmacy according to claim 4, it is characterized in that the diameter d of described spiral tube and the ratio d of its screw diameter D: D=1: (8～16), the spiral step-length h of spiral tube and the ratio h of the diameter d of spiral tube: d=1: (1.2～4).
6. method for processing waste water of biological pharmacy according to claim 1, it is characterized in that inside and outside circle diameter D1, the D2 of described chuck and the diameter d of spiral tube, the relation between screw diameter D meet: D2>D>D1, (D2-D1) >2d; In chuck, be provided with flow apron.
7. method for processing waste water of biological pharmacy according to claim 1, the temperature that it is characterized in that described sterilizing district is 101～133 ℃, the temperature of heat preservation zone is 100～126 ℃; The residence time in heat preservation zone is for being more than or equal to 1 second.
8. method for processing waste water of biological pharmacy according to claim 7, the temperature that it is characterized in that described sterilizing district is 105～130 ℃, the temperature of heat preservation zone is 105～121 ℃; The residence time in heat preservation zone is 3～60 seconds.
9. method for processing waste water of biological pharmacy according to claim 1, is characterized in that the diameter d 2 of described rotating wash bowl and the ratio of described spiral tube diameter d are 1: (2～10).
10. method for processing waste water of biological pharmacy according to claim 1, is characterized in that described rotating wash bowl is soft rotating wash bowl, and its surfaceness is 0.1～1mm.
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| CN201310067018.9A CN104016428B (en) | 2013-03-01 | 2013-03-01 | Method for processing waste water of biological pharmacy |
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| CN201310067018.9A CN104016428B (en) | 2013-03-01 | 2013-03-01 | Method for processing waste water of biological pharmacy |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN200981869Y (en) * | 2006-11-30 | 2007-11-28 | 中国辐射防护研究院 | Virus inactivation device |
| CN101221025A (en) * | 2008-02-04 | 2008-07-16 | 北京远东嘉创楼宇智能科技发展有限公司 | Automatic cleaning system for cleaning ball condenser |
| CN201628450U (en) * | 2009-12-31 | 2010-11-10 | 海南维瑅瑷生物工程技术有限公司 | Vacuum low-temperature dryer |
| CN102371260A (en) * | 2010-08-23 | 2012-03-14 | 葛绍忠 | Novel automatic pipeline cleaning device |
| CN202211138U (en) * | 2011-08-08 | 2012-05-09 | 上海冠生园蜂制品有限公司 | On-line osmophilic yeast killing device |
-
2013
- 2013-03-01 CN CN201310067018.9A patent/CN104016428B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN200981869Y (en) * | 2006-11-30 | 2007-11-28 | 中国辐射防护研究院 | Virus inactivation device |
| CN101221025A (en) * | 2008-02-04 | 2008-07-16 | 北京远东嘉创楼宇智能科技发展有限公司 | Automatic cleaning system for cleaning ball condenser |
| CN201628450U (en) * | 2009-12-31 | 2010-11-10 | 海南维瑅瑷生物工程技术有限公司 | Vacuum low-temperature dryer |
| CN102371260A (en) * | 2010-08-23 | 2012-03-14 | 葛绍忠 | Novel automatic pipeline cleaning device |
| CN202211138U (en) * | 2011-08-08 | 2012-05-09 | 上海冠生园蜂制品有限公司 | On-line osmophilic yeast killing device |
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