CN104014002A - Hyaluronic acid-based postoperative anti-adhesive membrane - Google Patents
Hyaluronic acid-based postoperative anti-adhesive membrane Download PDFInfo
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- CN104014002A CN104014002A CN201410262045.6A CN201410262045A CN104014002A CN 104014002 A CN104014002 A CN 104014002A CN 201410262045 A CN201410262045 A CN 201410262045A CN 104014002 A CN104014002 A CN 104014002A
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- hyaluronic acid
- film
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- adhered
- postoperative anti
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Abstract
The invention relates to the technical field of biological materials and particularly relates to a hyaluronic acid-based postoperative anti-adhesive membrane. The hyaluronic acid-based postoperative anti-adhesive membrane consists of the following components in percentage by weight: 55%-96% of hyaluronic acid, 1%-8% of glycerol, 0%-5% of citric acid, 0.5%-1% of antibiotics and the balance of water. The hyaluronic acid-based postoperative anti-adhesive membrane disclosed by the invention is used for separating an injured tissue from a normal serosa to achieve space-blocking and lubricating effects, and therefore, friction is reduced; bleeding and effusion are inhibited, number of blood blocks forming a permanent adhesion skeleton can be reduced, and fibrous protein deposition is inhibited; postoperative inflammatory cell transfer and phagocytosis are inhibited, and wound healing is promoted; growth and differentiation of serosa mesothelial cells are stimulated, so that the inured serosa achieves physiological repair, and therefore, the hyaluronic acid-based postoperative anti-adhesive membrane has excellent postoperative anti-adhesive effect.
Description
Technical field
The present invention relates to technical field of biological materials, especially relate to the postoperative anti-film that is adhered of a kind of hyaluronic acid-based.
Background technology
As clinical common phenomenon, surgical postoperative adhesion can cause serious clinical complication, as intestinal obstruction, abdominal cavity and pelvic pain, infertility etc., increases the difficulty of operation again and the potential danger that further complication occurs.Adhesion is often followed after common abdominal cavity, gynecological, orthopedics and operation on vessels of heart, in the process of tissue reparation when conventionally betiding separated tissue surface and being attached on together, may be interpreted as adhering between tissue and organ.When affecting normal structure function, adhesion becomes post-operative complication.External investigation discovery, 54%～74% small intestinal obstruction is caused by abdominal adhesions.The main cause of women's pelvic adhesion is operation, infection and endometriosis, and more than 55% pelvic adhesion patient is caused by gynecilogical operation.U.S.'s statistical data of 1993 shows, is used for the treatment of the expense of abdominal adhesions aspect up to 1.2 hundred million U.S. dollars.Therefore, the reason of further investigation Adhesion formation has become the primary study direction of current surgical field with prevention and the posterior synechiae of minimizing surgical operation.
Hyaluronic acid (Hyaluronic acid, HA) is to be present in the acid mucopolysaccharide of a kind of polyanion in extracellular matrix in biological tissue, the screw cylindrical structure that is spatially rigidity, the inner side of post is owing to existing a large amount of hydroxyls to produce strongly hydrophilic, and hyaluronan molecule is locked in the hydrone of its combination in its Double helix column structure, make moisture be difficult for running off, have special water retention, the anti-aspect that is adhered has the excellent anti-performance that is adhered after surgery.
Summary of the invention
The technical problem to be solved in the present invention is: in order to overcome the postoperative anti-postoperative anti-problem that is adhered weak effect that is adhered film of the prior art.The invention provides that a kind of hyaluronic acid-based is postoperative anti-is adhered film, there is the excellent postoperative anti-effect that is adhered.
The technical solution adopted for the present invention to solve the technical problems is: a kind of hyaluronic acid-based is postoperative to be prevented being adhered film, and each component and each component weight percent content are:
Hyaluronic acid 55-96%
Glycerol 1-8%
Citric acid 0-5%
Antibiotic 0.5-1%
Surplus is water.
Particularly, described hyaluronic molecular weight is 8700.
Particularly, described antibiotic is a kind of in gentamycin, metronidazole or ciprofloxacin.
The postoperative anti-preparation method that is adhered film of hyaluronic acid-based, comprises the steps:
Step 1) by weight percentage containing measuring each composition, stir, be then mixed with the solution that mass concentration is 4-10wt%, fully stir into uniform solution,
Step 2) it is even that uniform solution step 1) obtaining is poured on spin coater spin coating into, and drying and forming-film at 60 ℃ is taken film off after cooling, obtains the postoperative anti-film that is adhered of hyaluronic acid-based.
The invention has the beneficial effects as follows: a kind of hyaluronic acid-based provided by the invention is postoperative to be prevented being adhered film, and wounded tissue is separated with normal serous coat, plays space obstacle effect and lubrication, reduces friction; Suppress hemorrhage and ooze out, reducing the clot quantity that can form permanent adhesion skeleton, suppressing fibrin calm; Suppress post-operation inflammatory cell migration and phagocytosis, promote wound healing; The growth and the differentiation that stimulate serous coat mesothelial cell, make wound serous coat reach physiological reparation, has the excellent postoperative anti-effect that is adhered.
The specific embodiment
Below in conjunction with specific embodiment, further the present invention is set forth, should be understood that and quote embodiment only for the present invention is described, and be not used in, limit the scope of the invention.
Embodiment 1
Hyaluronic acid-based is postoperative to be prevented being adhered a film, and each component and each component weight percent content are: the hyaluronic acid 55% that molecular weight is 8700, and glycerol 8%, citric acid 5%, gentamycin 1%, surplus is water.
The postoperative anti-preparation method that is adhered film of hyaluronic acid-based, comprises the steps:
Step 1) by weight percentage containing measuring each composition, stir, be then mixed with the solution that mass concentration is 4wt%, fully stir into uniform solution,
Step 2) it is even that uniform solution step 1) obtaining is poured on spin coater spin coating into, and drying and forming-film at 60 ℃ is taken film off after cooling, obtains the postoperative anti-film that is adhered of hyaluronic acid-based.
Embodiment 2
Hyaluronic acid-based is postoperative to be prevented being adhered a film, and each component and each component weight percent content are: the hyaluronic acid 96% that molecular weight is 8700, and glycerol 1%, ciprofloxacin 0.5%, surplus is water.
The postoperative anti-preparation method that is adhered film of hyaluronic acid-based, comprises the steps:
Step 1) by weight percentage containing measuring each composition, stir, be then mixed with the solution that mass concentration is 10wt%, fully stir into uniform solution,
Step 2) it is even that uniform solution step 1) obtaining is poured on spin coater spin coating into, and drying and forming-film at 60 ℃ is taken film off after cooling, obtains the postoperative anti-film that is adhered of hyaluronic acid-based.
Embodiment 3
Hyaluronic acid-based is postoperative to be prevented being adhered a film, and each component and each component weight percent content are: the hyaluronic acid 80% that molecular weight is 8700, and glycerol 5%, citric acid 1%, metronidazole 0.7%, surplus is water.
The postoperative anti-preparation method that is adhered film of hyaluronic acid-based, comprises the steps:
Step 1) by weight percentage containing measuring each composition, stir, be then mixed with the solution that mass concentration is 8wt%, fully stir into uniform solution,
Step 2) it is even that uniform solution step 1) obtaining is poured on spin coater spin coating into, and drying and forming-film at 60 ℃ is taken film off after cooling, obtains the postoperative anti-film that is adhered of hyaluronic acid-based.
Embodiment 4
Hyaluronic acid-based is postoperative to be prevented being adhered a film, and each component and each component weight percent content are: the hyaluronic acid 90% that molecular weight is 8700, and glycerol 3%, citric acid 1%, gentamycin 1%, surplus is water.
The postoperative anti-preparation method that is adhered film of hyaluronic acid-based, comprises the steps:
Step 1) by weight percentage containing measuring each composition, stir, be then mixed with the solution that mass concentration is 5wt%, fully stir into uniform solution,
Step 2) it is even that uniform solution step 1) obtaining is poured on spin coater spin coating into, and drying and forming-film at 60 ℃ is taken film off after cooling, obtains the postoperative anti-film that is adhered of hyaluronic acid-based.
Embodiment 5
Hyaluronic acid-based is postoperative to be prevented being adhered a film, and each component and each component weight percent content are: the hyaluronic acid 65% that molecular weight is 8700, and glycerol 3%, citric acid 2%, metronidazole 0.8%, surplus is water.
The postoperative anti-preparation method that is adhered film of hyaluronic acid-based, comprises the steps:
Step 1) by weight percentage containing measuring each composition, stir, be then mixed with the solution that mass concentration is 9wt%, fully stir into uniform solution,
Step 2) it is even that uniform solution step 1) obtaining is poured on spin coater spin coating into, and drying and forming-film at 60 ℃ is taken film off after cooling, obtains the postoperative anti-film that is adhered of hyaluronic acid-based.
The above-mentioned foundation desirable embodiment of the present invention of take is enlightenment, and by above-mentioned description, relevant staff can, within not departing from the scope of this invention technological thought, carry out various change and modification completely.
The technical scope of this invention is not limited to the content in description, must determine its technical scope according to claim scope.
Claims (4)
1. hyaluronic acid-based is postoperative prevents being adhered a film, it is characterized in that each component and each component weight percent content are:
Hyaluronic acid 55-96%
Glycerol 1-8%
Citric acid 0-5%
Antibiotic 0.5-1%
Surplus is water.
2. a kind of hyaluronic acid-based as claimed in claim 1 is postoperative prevents being adhered film, it is characterized in that: described hyaluronic molecular weight is 8700.
3. a kind of hyaluronic acid-based as claimed in claim 1 is postoperative anti-is adhered film, it is characterized in that: described antibiotic is a kind of in gentamycin, metronidazole or ciprofloxacin.
4. the postoperative anti-preparation method that is adhered film of a kind of hyaluronic acid-based as described in claim 1-3 any one, is characterized in that comprising the steps:
Step 1) by weight percentage containing measuring each composition, stir, be then mixed with the solution that mass concentration is 4-10wt%, fully stir into uniform solution,
Step 2) it is even that uniform solution step 1) obtaining is poured on spin coater spin coating into, and drying and forming-film at 60 ℃ is taken film off after cooling, obtains the postoperative anti-film that is adhered of hyaluronic acid-based.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410262045.6A CN104014002A (en) | 2014-06-13 | 2014-06-13 | Hyaluronic acid-based postoperative anti-adhesive membrane |
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| CN201410262045.6A CN104014002A (en) | 2014-06-13 | 2014-06-13 | Hyaluronic acid-based postoperative anti-adhesive membrane |
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| CN201410262045.6A Pending CN104014002A (en) | 2014-06-13 | 2014-06-13 | Hyaluronic acid-based postoperative anti-adhesive membrane |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019134725A3 (en) * | 2018-01-04 | 2019-10-03 | PlantTec Medical GmbH | Medicament containing carboxymethylated starch and a citrate and/or citric acid for use in the reduction of post-operative adhesions |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1827179A (en) * | 2005-03-04 | 2006-09-06 | 蒋婧 | Post-surgery functional barrier film and method for preparing the same |
| CN101352453A (en) * | 2007-07-25 | 2009-01-28 | 凌沛学 | Pharmaceutical composition for preventing intestinal adhesion |
| CN101444636A (en) * | 2009-01-05 | 2009-06-03 | 北京化工大学 | Degradable multiporous faecula/PVA biological film and preparation method thereof |
| CN103041448A (en) * | 2013-01-17 | 2013-04-17 | 苏州博创同康生物工程有限公司 | Compound polysaccharide hemostatic material and preparation method and application thereof |
| CN103055353A (en) * | 2013-01-21 | 2013-04-24 | 华熙福瑞达生物医药有限公司 | Method for preparing anti-adhesive membrane for surgeries |
-
2014
- 2014-06-13 CN CN201410262045.6A patent/CN104014002A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1827179A (en) * | 2005-03-04 | 2006-09-06 | 蒋婧 | Post-surgery functional barrier film and method for preparing the same |
| CN101352453A (en) * | 2007-07-25 | 2009-01-28 | 凌沛学 | Pharmaceutical composition for preventing intestinal adhesion |
| CN101444636A (en) * | 2009-01-05 | 2009-06-03 | 北京化工大学 | Degradable multiporous faecula/PVA biological film and preparation method thereof |
| CN103041448A (en) * | 2013-01-17 | 2013-04-17 | 苏州博创同康生物工程有限公司 | Compound polysaccharide hemostatic material and preparation method and application thereof |
| CN103055353A (en) * | 2013-01-21 | 2013-04-24 | 华熙福瑞达生物医药有限公司 | Method for preparing anti-adhesive membrane for surgeries |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019134725A3 (en) * | 2018-01-04 | 2019-10-03 | PlantTec Medical GmbH | Medicament containing carboxymethylated starch and a citrate and/or citric acid for use in the reduction of post-operative adhesions |
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Application publication date: 20140903 |