CN104011209A - 病毒基因表达的抑制 - Google Patents
病毒基因表达的抑制 Download PDFInfo
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- CN104011209A CN104011209A CN201280053081.0A CN201280053081A CN104011209A CN 104011209 A CN104011209 A CN 104011209A CN 201280053081 A CN201280053081 A CN 201280053081A CN 104011209 A CN104011209 A CN 104011209A
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- nucleic acid
- sirna
- acid molecule
- guanidinopropyl
- virus
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Classifications
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3527—Other alkyl chain
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
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- Microbiology (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
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Applications Claiming Priority (3)
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| ZA2011/07890 | 2011-10-28 | ||
| ZA201107890 | 2011-10-28 | ||
| PCT/IB2012/055915 WO2013061295A1 (en) | 2011-10-28 | 2012-10-26 | Inhibition of viral gene expression |
Publications (1)
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| CN104011209A true CN104011209A (zh) | 2014-08-27 |
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| CN201280053081.0A Pending CN104011209A (zh) | 2011-10-28 | 2012-10-26 | 病毒基因表达的抑制 |
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Cited By (1)
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| CN110678447A (zh) * | 2017-06-16 | 2020-01-10 | 卫材R&D管理有限公司 | 经修饰的核酸单体化合物及寡核酸类似物 |
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| AU2013285698A1 (en) | 2012-07-03 | 2015-02-19 | Biomarin Technologies B.V. | Oligonucleotide for the treatment of muscular dystrophy patients |
| CN107849567B (zh) * | 2015-06-26 | 2024-07-23 | 苏州瑞博生物技术股份有限公司 | 一种siRNA、含有该siRNA的药物组合物和缀合物及它们的应用 |
| CA2996722A1 (en) | 2015-07-17 | 2017-01-26 | Arcturus Therapeutics, Inc. | Compositions and agents against hepatitis b virus and uses thereof |
| US20170137821A1 (en) | 2015-07-17 | 2017-05-18 | Arcturus Therapeutics, Inc. | Molecules and agents for treating hepatitis b virus |
| CN110945132B (zh) * | 2017-12-01 | 2024-04-05 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| ES3023937T3 (en) * | 2018-10-31 | 2025-06-03 | The Westmead Institute For Medical Res | Pharmaceutical compositions for use in treating an hbv or hdv infection |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1814614A (zh) * | 2005-02-06 | 2006-08-09 | 中国人民解放军军事医学科学院毒物药物研究所 | 核酸、肽核酸衍生物及它们的用途 |
| WO2009038266A1 (en) * | 2007-09-17 | 2009-03-26 | Mogam Biotechnology Research Institute | Method for enhancing serum stability and lowering immune response of sirna down-regulating gene expression of hbv or hcv |
-
2012
- 2012-10-26 CN CN201280053081.0A patent/CN104011209A/zh active Pending
- 2012-10-26 IN IN3921CHN2014 patent/IN2014CN03921A/en unknown
- 2012-10-26 CA CA2853609A patent/CA2853609A1/en not_active Abandoned
- 2012-10-26 RU RU2014121304/10A patent/RU2014121304A/ru not_active Application Discontinuation
- 2012-10-26 EP EP12798850.9A patent/EP2771466A1/en not_active Withdrawn
- 2012-10-26 WO PCT/IB2012/055915 patent/WO2013061295A1/en active Application Filing
- 2012-10-26 US US14/354,180 patent/US20140350080A1/en not_active Abandoned
- 2012-10-26 AP AP2014007650A patent/AP2014007650A0/xx unknown
- 2012-10-26 BR BR112014010134A patent/BR112014010134A2/pt not_active IP Right Cessation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1814614A (zh) * | 2005-02-06 | 2006-08-09 | 中国人民解放军军事医学科学院毒物药物研究所 | 核酸、肽核酸衍生物及它们的用途 |
| WO2009038266A1 (en) * | 2007-09-17 | 2009-03-26 | Mogam Biotechnology Research Institute | Method for enhancing serum stability and lowering immune response of sirna down-regulating gene expression of hbv or hcv |
Non-Patent Citations (3)
| Title |
|---|
| DALIBOR ODADZIC ET AL.: "Synthesis of 2′-O-modified adenosine building blocks and application for RNA interference", 《BIOORGANIC & MEDICINAL CHEMISTRY》, vol. 16, no. 1, 15 September 2007 (2007-09-15), pages 518 - 529 * |
| JOLANTA BRZEZINSKA ET AL.: "Synthesis of 2′-O-guanidinopropyl-modified nucleoside phosphoramidites and their incorporation into siRNAs targeting hepatitis B virus", 《BIOORGANIC & MEDICINAL CHEMISTRY》, vol. 20, 21 December 2011 (2011-12-21), pages 1594 - 1606, XP055053033, DOI: 10.1016/j.bmc.2011.12.024 * |
| JUSTIN HEAN ET AL.: "Inhibition of hepatitis B virus replication in vivo using lipoplexes containing altritol-modified antiviral siRNAs", 《ARTIFICIAL DNA: PNA & XNA》, vol. 1, no. 1, 31 July 2010 (2010-07-31), pages 17 - 26, XP055073339 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110678447A (zh) * | 2017-06-16 | 2020-01-10 | 卫材R&D管理有限公司 | 经修饰的核酸单体化合物及寡核酸类似物 |
| CN110678447B (zh) * | 2017-06-16 | 2023-12-12 | 卫材R&D管理有限公司 | 经修饰的核酸单体化合物及寡核酸类似物 |
Also Published As
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| IN2014CN03921A (enrdf_load_stackoverflow) | 2015-09-04 |
| BR112014010134A2 (pt) | 2019-09-24 |
| WO2013061295A1 (en) | 2013-05-02 |
| CA2853609A1 (en) | 2013-05-02 |
| RU2014121304A (ru) | 2015-12-10 |
| US20140350080A1 (en) | 2014-11-27 |
| EP2771466A1 (en) | 2014-09-03 |
| AP2014007650A0 (en) | 2014-05-31 |
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Application publication date: 20140827 |