CN1039969C - Method for preparing "kuhuang" injection - Google Patents
Method for preparing "kuhuang" injection Download PDFInfo
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- CN1039969C CN1039969C CN93110551A CN93110551A CN1039969C CN 1039969 C CN1039969 C CN 1039969C CN 93110551 A CN93110551 A CN 93110551A CN 93110551 A CN93110551 A CN 93110551A CN 1039969 C CN1039969 C CN 1039969C
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Abstract
The present invention relates to a method for preparing kuhuang injection, which uses oriental wormwood and bupleurum root decoction pieces for making A liquid, rhubarb decoction pieces for making B liquid, flavescent sophora root and folium isatidis decoction pieces and the medical dregs of the A liquid for making C liquid. The B liquid and the C liquid are mixed to be added with injection water, refrigerated, filtrated, decarbonized, filtrated and condensed, and then the A liquid and the injection water are added to be made into the injection by tween-80 operation. The kuhuang injection prepared by the present invention has the advantages of good stability, no deposition and good clarity, and can be used for treating various virus rephepatitises in an ictericserumhepatitie type. The treating effect is good, and no side effect exists.
Description
The present invention relates to a kind of preparation method of Chinese medicine injection, particularly be applicable to the preparation method of the KUHUANG ZHUSHEYE of the various icteric viral hepatitis of treatment.
KUHUANG ZHUSHEYE is to select China's tradition authentic medicinal herbs Radix Sophorae Flavescentis, Radix Et Rhizoma Rhei, Herba Artemisiae Scopariae, Radix Bupleuri and Folium Isatidis for use, extracts the refining injection that forms through scientific method.The Herba Artemisiae Scopariae Decoction that this prescription derives from the treatise on Febrile Diseases simplifies sanction through adding, and changes injection into by oral formulations.In the preparation and discussion of preparation method in the past as the KUHUANG ZHUSHEYE of the new medical college of preparation and Jiangsu " scientific research data a collection of selected materials " the 2nd phase 131-132 page or leaf in 1977 of " Jiangsu medicine " the 8th phase in 1979 KUHUANG ZHUSHEYE of the 9th page, first liquid is by Herba Artemisiae Scopariae, the Radix Bupleuri preparation, second liquid is by Radix Sophorae Flavescentis, Radix Et Rhizoma Rhei and Folium Isatidis decoct together, extract together after three kinds of raw medicinal materials decoct in the second liquid, adopt secondary alcohol to handle, make impurity such as tannin be difficult for eliminating, directly influenced the clarity of injection, make the medicine poor stability, and active ingredient anthraquinone class and Radix Sophorae Flavescentis active component alkaloids generate salt in the Radix Et Rhizoma Rhei, dissolubility is little in alcoholic solution, effective ingredient is most of like this loses, and has directly influenced the curative effect of injection.
The preparation method that the purpose of this invention is to provide a kind of KUHUANG ZHUSHEYE, the KUHUANG ZHUSHEYE good stability of this method preparation, deposit-free and clarity are good.
The present invention is by Radix Bupleuri decoction pieces, capillaris tablet, Radix Sophorae Flavescentis decoction pieces, Radix Et Rhizoma Rhei decoction piece and the preparation of Folium Isatidis decoction pieces, and first liquid is got capillaris tablet 250-300 gram, Radix Bupleuri decoction pieces 250-300 gram add the water distillation collect distillate again redistillation make; Second liquid is got the steaming and decocting of Radix Et Rhizoma Rhei decoction piece 100-250 gram adding distil water, is concentrated, and uses Ethanol Treatment; Third liquid is got Radix Sophorae Flavescentis decoction pieces 80-100 gram, Folium Isatidis decoction pieces 180-200 gram and first liquid capillaris tablet, the steaming and decocting of Radix Bupleuri decoction pieces medicinal residues adding distil water, filtration, is concentrated, and uses Ethanol Treatment; Second liquid and third liquid are merged, add injection water, cold preservation, filter, take off charcoal, filtration, concentrate or second liquid and third liquid add injection water, cold preservation respectively, filter, remerge and take off charcoal, filtration, concentrate; Add first liquid and injection water, tween 80 again, transfer PH to 7.5-8.5, make injection.
The present invention has kept the extracting method of Radix Bupleuri, Herba Artemisiae Scopariae volatile oil, because re-distilled liquid, and stable in properties, therefore, do not add tween 80 this moment, add when changing the preparation injection into, and the former technology of amount ratio reduces, and guarantees that the clarity of injection is good.The present invention adopts Radix Et Rhizoma Rhei and Radix Sophorae Flavescentis, Folium Isatidis to separate the method for extracting, and has guaranteed the stability of injection, and deposit-free is separated out.Because separately extract, composition anthraquinone class in the Radix Et Rhizoma Rhei and Radix Sophorae Flavescentis active component alkaloids can not generate salt, and effective ingredient is difficult for loss like this, makes the preparation long shelf-life, and curative effect is good, has no side effect.The second liquid and the third liquid separate processes help commercial production, have guaranteed the large-scale production of pharmaceutical factory.
Embodiment 1
First liquid: get capillaris tablet, each 250 gram of Radix Bupleuri decoction pieces, adding distil water distills in right amount, collects distillate 650-750 milliliter, and redistillation is collected 300-400 milliliter distillate, gets first liquid.
Second liquid: get Radix Et Rhizoma Rhei decoction piece 100 grams, adding distil water steaming and decocting 2 times, the 1st time 1 hour, the 2nd time 45 minutes, merge and steam liquid, be concentrated into the 250-300 milliliter, use Ethanol Treatment 3 times.
The 1st time: concentrated solution adds ethanol to 70-75%, leaves standstill about 48 hours, and filtered and recycled gets I liquid.
The 2nd time: add ethanol to 80-85% in the I liquid, leave standstill more than 48 hours, filtrate is transferred PH to 8-9 with 20%NaOH, and cold preservation (0 ℃-4 ℃) 24-48 hour is filtered, and reclaims ethanol and gets II liquid.
The 3rd time: add ethanol to 85-87% in the II liquid, cold putting (0 ℃-4 ℃) filtered more than 48 hours, reclaimed ethanol and got second liquid.
Third liquid is got Radix Sophorae Flavescentis decoction pieces 80 gram, Folium Isatidis decoction pieces 187 grams, capillaris tablet, Radix Bupleuri decoction pieces medicinal residues, adding distil water steaming and decocting 2 times, each about 1.5 hours, filter, be concentrated into the 250-350 milliliter, by second liquid method with Ethanol Treatment 3 times after, third liquid.
The second liquid and third liquid are merged, and it is an amount of to add injection water, and charcoal is filtered, takes off in cold preservation (0 ℃-4 ℃) 25-48 hour, be concentrated into the 400-500 milliliter, add first liquid and injection water again, 2 gram tween 80s, to 1000 milliliters, transfer PH to 7.5-8.0 with 20%NaOH, make injection by the injection conventional method.
Embodiment 2
First liquid: with embodiment 1.
Second liquid: get Radix Et Rhizoma Rhei decoction piece 150 grams, method for making is with embodiment 1.
Third liquid: get Radix Sophorae Flavescentis decoction pieces 90 grams, Folium Isatidis decoction pieces 200 grams, method for making is with embodiment 1.
The second liquid and third liquid are merged, it is an amount of to add injection water, cold preservation (0 ℃-4 ℃) 48-72 hour is filtered, and takes off charcoal with 0.5% active carbon, filter, be concentrated into the 400-500 milliliter, add first liquid and injection water again, 2 gram tween 80s to 1000 milliliter, transfer PH to 7.5-8.0 with 20%NaOH, make injection by the injection conventional method.
Embodiment 3
First liquid: get capillaris tablet, each 300 gram of Radix Bupleuri decoction pieces, method for making is with embodiment 1.
Second liquid: get Radix Et Rhizoma Rhei decoction piece 200 grams, steaming and decocting is concentrated into the 300-400 milliliter with embodiment 1, uses Ethanol Treatment 3 times, with embodiment 1.
Third liquid: get Radix Sophorae Flavescentis decoction pieces 100 grams, Folium Isatidis decoction pieces 200 grams, method for making is with embodiment 1.
It is an amount of that second liquid is added injection water, cold preservation (0 ℃-4 ℃) 48-72 hour, and it is an amount of that third liquid is added injection water, cold preservation (0 ℃-4 ℃) 48-72 hour.Filter respectively, merge, take off charcoal, filter, be concentrated into the 400-500 milliliter, survey Radix Et Rhizoma Rhei anthraquinone content, add first liquid and injection water again, 2 gram tween 80s to 1000 milliliter are transferred PH to 7.5-8.5 with 20%NaOH, with the filtration of 1% Pulvis Talci, make injection by the injection conventional method.
Embodiment 4
First liquid: method for making is with embodiment 1.
Second liquid: get Radix Et Rhizoma Rhei decoction piece 250 grams, steaming and decocting is concentrated into the 350-500 milliliter with embodiment 1, uses Ethanol Treatment 3 times, with embodiment 1.
Third liquid: get Radix Sophorae Flavescentis decoction pieces 100 grams, Folium Isatidis decoction pieces 200 grams, method for making is with embodiment 3.
Make conventional injection with embodiment 3 methods.
Claims (6)
1, a kind of preparation method of KUHUANG ZHUSHEYE, by Radix Bupleuri decoction pieces, capillaris tablet, Radix Sophorae Flavescentis decoction pieces, Radix Et Rhizoma Rhei decoction piece and the preparation of Folium Isatidis decoction pieces, first liquid is got capillaris tablet 250-300 gram, Radix Bupleuri decoction pieces 250-300 gram adds the water distillation, collection distillate redistillation again makes, it is characterized in that second liquid gets the steaming and decocting of Radix Et Rhizoma Rhei decoction piece 100-250 gram adding distil water, concentrates, use Ethanol Treatment; Third liquid is got Radix Sophorae Flavescentis decoction pieces 80-100 gram, Folium Isatidis decoction pieces 180-200 gram and first liquid capillaris tablet, the steaming and decocting of Radix Bupleuri decoction pieces medicinal residues adding distil water, filtration, is concentrated, and uses Ethanol Treatment; Second liquid and third liquid are merged, add injection water, cold preservation, filter, take off charcoal, filtration, concentrate, add again first liquid and injection water, tween 80, transfer PH to 7.5-8.5, make injection.
2, the preparation method of KUHUANG ZHUSHEYE according to claim 1 is characterized in that Ethanol Treatment 3 times of second liquid.
3, the preparation method of KUHUANG ZHUSHEYE according to claim 1 and 2 is characterized in that Ethanol Treatment 3 times of third liquid.
4, a kind of preparation method of KUHUANG ZHUSHEYE, by Radix Bupleuri decoction pieces, capillaris tablet, Radix Sophorae Flavescentis decoction pieces, Radix Et Rhizoma Rhei decoction piece and the preparation of Folium Isatidis decoction pieces, first liquid is got capillaris tablet 250-300 gram, Radix Bupleuri decoction pieces 250-300 gram adds the water distillation, collection distillate redistillation again makes, it is characterized in that second liquid gets the steaming and decocting of Radix Et Rhizoma Rhei decoction piece 100-250 gram adding distil water, concentrates, use Ethanol Treatment; Third liquid is got Radix Sophorae Flavescentis decoction pieces 80-100 gram, Folium Isatidis decoction pieces 180-200 gram and first liquid capillaris tablet, the steaming and decocting of Radix Bupleuri decoction pieces medicinal residues adding distil water, filtration, is concentrated, and uses Ethanol Treatment; The second liquid and third liquid add injection water, cold preservation respectively, filter, remerge and take off charcoal, filtration, concentrated; Add first liquid and injection water, tween 80 again, transfer PH to 7.5-8.5, make injection.
5, the preparation method of KUHUANG ZHUSHEYE according to claim 4 is characterized in that Ethanol Treatment 3 times of second liquid.
6,, it is characterized in that Ethanol Treatment 3 times of third liquid according to the preparation method of claim 4 or 5 described KUHUANG ZHUSHEYE.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93110551A CN1039969C (en) | 1993-01-18 | 1993-01-18 | Method for preparing "kuhuang" injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93110551A CN1039969C (en) | 1993-01-18 | 1993-01-18 | Method for preparing "kuhuang" injection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1075887A CN1075887A (en) | 1993-09-08 |
| CN1039969C true CN1039969C (en) | 1998-09-30 |
Family
ID=4988406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93110551A Ceased CN1039969C (en) | 1993-01-18 | 1993-01-18 | Method for preparing "kuhuang" injection |
Country Status (1)
| Country | Link |
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| CN (1) | CN1039969C (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1062181C (en) * | 1997-07-16 | 2001-02-21 | 山西金晶药业有限公司 | Compound sophora flavescens injection |
| CN100350896C (en) * | 2002-04-22 | 2007-11-28 | 成冬生 | Raw rhubarb powder injection and its prepn |
| CN101085054B (en) * | 2007-06-26 | 2010-05-26 | 天津生机集团有限公司 | Liver-nourishing powder containing bupleurum, rhubarb and other medicine for aquatic animals |
| CN101524411B (en) * | 2009-03-05 | 2011-12-21 | 常熟雷允上制药有限公司 | High-capacity Kuhuang injection and preparation method thereof |
| CN102885928B (en) * | 2012-09-20 | 2014-07-23 | 中国人民解放军第三0二医院 | Chinese medicinal injection for treating jaundice and preparation method thereof |
| CN105663273A (en) * | 2016-03-03 | 2016-06-15 | 于红艳 | Pharmaceutical composition for auxiliary treatment on newborn infant hemolysis induced by ABO incompatibility and application of pharmaceutical composition |
| CN107398092A (en) * | 2017-07-31 | 2017-11-28 | 芜湖杨燕制药有限公司 | Filtrate cycle recovery process in the production of traditional Chinese medicine |
-
1993
- 1993-01-18 CN CN93110551A patent/CN1039969C/en not_active Ceased
Non-Patent Citations (1)
| Title |
|---|
| 《江苏医药》1979年第8期 1979.1.1 南京医学院附属医院中草药针剂室"苦黄注射液的制备" * |
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| Publication number | Publication date |
|---|---|
| CN1075887A (en) | 1993-09-08 |
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