CN103989474B - Human eye vision electro physiology analog and method - Google Patents
Human eye vision electro physiology analog and method Download PDFInfo
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- CN103989474B CN103989474B CN201410259010.7A CN201410259010A CN103989474B CN 103989474 B CN103989474 B CN 103989474B CN 201410259010 A CN201410259010 A CN 201410259010A CN 103989474 B CN103989474 B CN 103989474B
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Abstract
The invention provides a kind of human eye vision electro physiology analog, comprise photoelectric conversion module, integral measurement module, shaping pulse module, timing module, time block, signal generating module, operation control module, inputting interface module and display interface module.External optical signals inputs to photoelectric conversion module, photoelectric conversion module, shaping pulse module, timing module, time block, signal generating module are connected successively, photoelectric conversion module is connected with operation control module through integral measurement module, and operation control module is connected with inputting interface module respectively with timing module, time block, signal generating module, display interface module.Present invention also offers the method for human eye vision electro physiology simulation.The advantage of human eye visual electrophysiology analog of the present invention and method is: can in quantitative simulation examination of visual electro physiology the visual electrophysiology of human eye when being subject to flash stimulation and pictorial stimulus movable, precision is high, be convenient to adjustment, be widely used in metering and quality inspection field.
Description
Technical field
The present invention relates to checkout gear and method, particularly a kind of human eye vision electro physiology analog and method.
Background technology
When human eye is subject to optical signal stimulation, the visual system of people can produce the corresponding signal of telecommunication after certain time-delay, is called visual electrophysiology signal.This signal detects in positions such as eye cornea, nose temporo or occipital lobes by electrode.The persistent period of visual electrophysiology signal is generally tens of to hundreds of millisecond, and amplitude is generally a few microvolt to hundreds of microvolt.
The process detecting visual electrophysiology signal is divided into human eye applying optical stimulus signal and measures visual electrophysiology signal two steps.Usually flash of light or pictorial stimulus signal is adopted in the examination of visual electro physiology such as electroretinogram, VEP project.The optical stimulus signal that persistent period is short, instantaneous brightness is high that the former sends for xenon lamp or LED can be single flash operation or periodically repeatedly glisten; The bright lattice of the bright dark chessboard pattern of the latter shown by display and the optical stimulus signal of dark lattice alternate are generally periodically repeatedly alternate.Human eye starts at the end of each flash pulse the response of flash stimulation, and is become at bright lattice the moment that dark lattice and dark lattice become bright lattice to start to the response of pictorial stimulus.Utilize standardized optical stimulus signal to stimulate human eye, the visual electrophysiology signal amplitude that measurement obtains and the ANOMALOUS VARIATIONS of time delay imply the Pathological Information of the different link of visual system.Such as, the measurement index of single flash electroretinogram comprise incubation period, a ripple and b ripple peak time and amplitude etc., and when the measurement index of pattern-reversal electroretinogram comprises the peak of P50 and N95 and amplitude etc.Prolongation during peak or the reduction of amplitude mean the local patholoic change of visual system usually, usually reference value corresponding with this inspection item for measurement result contrasted and diagnose in clinical examination of visual electro physiology.
The instrument carrying out vision disorders diagnosis by measuring visual electrophysiology signal is referred to as visual electrophysiology instrument.The parameter of the flash stimulation that visual electrophysiology instrument sends comprises flash intensity, flash of light time-histories, flashing rate, background luminance etc., the parameter of pictorial stimulus comprises the brightness, pattern reversal frequency etc. of the bright lattice of figure and dark lattice, the visual electrophysiology signal parameter that it detects comprises amplitude and time, the former i.e. the peak value of signal and the size of valley, namely the latter applies optical stimulus signal to there is the time that the feature signal of telecommunication experiences, and illustrates the synchronizing relay relation of the signal of telecommunication and optical stimulus signal.The change of photostimulation parameter directly affects the vision response of human eye, thus affects the diagnosis of doctor to vision disorders.For this reason, in the normative document that the world clinical visual electrophysiology association issues to examination of visual electro physiology in the value of photostimulation parameter used have clear and definite regulation, and need regularly to carry out testing calibration to instrument.Such as, in file, the flash intensity of required standard flash electroretinogram inspection is 3.0cds/m2, error is no more than ± and 10%, flash of light time-histories is no more than 5ms.Under standardized optical stimulus signal effect, visual electrophysiology instrument also needs amplitude and the time parameter of the visual electrophysiology signal measuring human eye exactly, the reliability of guarantee clinical diagnosis.Visual electrophysiology instrument is widely used in the clinical diagnosis of various fundus oculi disease, and as retinopathy, maculopathy, optic nerve illness, cataract and glaucoma etc., to infant, old people, uncooperative or malingering blindness person, more can be used as effective objective visual function and detect.Visual electrophysiology instrument is detection by quantitative instrument.Its photostimulation parameter and the whether accurate diagnosis directly affecting doctor of electric signal measurement result, concern health and the interests of patient, so need to utilize special testing tool to carry out periodic detection to it.
In order to realize the monitoring and testing of visual electrophysiology instrument, needing the device of a set of energy quantitative simulation human eye vision bioelectrical activity, following requirement need be met simultaneously:
Automatic identification blink stimulation and pictorial stimulus, and send corresponding standard electric signal according to the type of photostimulation and parameter, thus the visual electrophysiology of simulation human eye is movable;
The flash intensity of flash stimulation, flash of light time-histories, flashing rate, background luminance can be measured;
Can measurement pattern stimulate bright lattice brightness, dark lattice brightness, pattern reversal frequency;
Can after optical stimulus signal being detected, the delay through certain hour sends standard electric signal;
Receive optical stimulus signal adjustable to the time delay sent between standard electric signal;
Be convenient to adjustment, to ensure the accuracy of self.
But in the prior art, not yet have human eye vision electro physiology analog or visual electrophysiology measuring device to occur, to the demand of energy quantitative simulation human eye vision bioelectrical activity device, prior art can't meet.
Summary of the invention
The object of the invention is to overcome prior art Problems existing and defect, a kind of type that automatically can identify photostimulation is provided, quantitative simulation human eye vision bioelectrical activity, carries out human eye vision electro physiology analog and the method for monitoring and testing to visual electrophysiology instrument.
For achieving the above object, human eye vision electro physiology analog provided by the invention, comprise photoelectric conversion module, integral measurement module, shaping pulse module, timing module, time block, signal generating module, operation control module, inputting interface module and display interface module, wherein: external optical signals inputs to described photoelectric conversion module, described photoelectric conversion module, shaping pulse module, timing module, time block, signal generating module is connected successively, described photoelectric conversion module is connected with described operation control module through described integral measurement module, described operation control module and described timing module, time block, signal generating module, display interface module is connected respectively with inputting interface module, optical stimulus signal is converted into the signal of telecommunication by described photoelectric conversion module, export described shaping pulse module and integral measurement module to, described shaping pulse module exports the square-wave signal corresponding with optical stimulus signal, described square-wave signal triggers described timing module and time block, described timing module judges photostimulation type and controls the timing from corresponding time point of described time block, described integral measurement module measures the brightness of optical stimulus signal and the integrated value of time under the Synchronization Control of described impulsive measurement module, described operation control module receives the parameter setting of described inputting interface module input, computing integral measurement result, and export the signal of telecommunication through described signal generating module, simultaneously, output state parameter and measurement result are to described display interface module.
Human eye visual electrophysiology analog of the present invention, wherein said operation control module adopts model to be the singlechip chip of STC89C51 and model to be the crystal oscillator chip able to programme of SG-8002 to form; The reference voltage chip that integral measurement module adopts model is the operational amplifier chip of OPA642, model is ADS804 12 modulus conversion chips, model is TL431 and model are that the singlechip chip of STC89C51 is formed; The scaling circuit that the operational amplifier chip that shaping pulse module is OP07AJ by two models is formed and model are that the NAND gate chip of 74LS312 is formed; The 74V1T32 that the monostable flipflop chip that timing module adopts model is the counter chip of 74LS90, model is 82C54 counter chip, model is 74LS121, model are or door chip, model are the NAND gate chip of 74LS132, model is forming with door chip of LN74SZ08; Time block employing model is that the counter chip of 82C54 is formed; Wherein: the data bit pin of the singlechip chip in operation control module and control bit pin are connected with display interface module with the counter chip in time block, signal generating module, inputting interface module with the singlechip chip of integral measurement module, timing module respectively with bus mode; The output pin of photoelectric detection module is connected with the in-phase input end of the in-phase input end of the operational amplifier chip in shaping pulse module with the operational amplifier chip in integral measurement module through resistance respectively; TXD with the RXD pin of the single-chip microcomputer in integral measurement module is corresponding with RXD and the TXD pin of the single-chip microcomputer in operation control module to be connected; The 2Y pin of the NAND gate chip in shaping pulse module is connected with the P2.1 pin of the singlechip chip in integral measurement module, correspondingly with 4A and the 4B pin of the B pin of the monostable flipflop chip of in timing module and A1 and the A2 pin of another monostable flipflop chip, the enumerator 0 of counter chip and GATE0 pin, NAND gate chip connects; 1Y pin that is in timing module or door chip is connected with the GATE0 pin of the counter chip in time block, A1 with the A2 pin of monostable flipflop chip is connected with the P2.0 pin of singlechip chip; The OUT0 pin of the chip in time block is connected with signal generating module.
For achieving the above object, the analogy method of human eye vision electro physiology analog provided by the invention, the method comprises the steps:
Step 1, is converted into the signal of telecommunication that amplitude is directly proportional to the brightness of optical stimulus signal by optical stimulus signal, and carries out integral measurement to this signal of telecommunication;
Step 2, identifies the type of optical stimulus signal, integral measurement signal is converted to square-wave signal, by the width of timing measuring square wave, comes identification blink stimulus signal and pictorial stimulus signal, if flash stimulation signal, perform next step with its time property difference; If pictorial stimulus signal, perform step 4;
Step 3, if the high level of luminous corresponding square wave, the low level of the corresponding square wave of the interval between twice luminescence, so, between high period, integral measurement result is as the intensity of flash pulse, and the integrated value of integral measurement result luminance vs. time as a setting between low period, the high level time of timing measuring result is as the time-histories of flash stimulation, high level time and low level time sum are as the cycle of flash stimulation, get the frequency as flash stimulation reciprocal, background luminance divided by interval brightness value as a setting, performs step 5 to the integrated value of time;
Step 4, subsection integral measurement is carried out with the edge of square-wave signal, square wave is in the bright trellis state of the corresponding pictorial stimulus of high level, square wave is in the dark trellis state of the corresponding pictorial stimulus of low level, carry out the integrated value that integral measurement obtains figure luminance vs. time when square wave is in high level and low level respectively, timing measuring obtains time value that high level continues and the time value that low level continues, and by two integrated values respectively divided by the corresponding time, and respectively as the brightness of the bright lattice of figure and dark lattice, the time value that the time value continued by high level and low level continue was added as the pattern reversal cycle, get its inverse as pattern reversal frequency, perform next step,
Step 5, inputting interface input setup parameter, integral measurement and timing measuring and operation result thereof export display interface to.
The advantage of human eye visual electrophysiology analog of the present invention and method is: owing to being provided with integral measurement module, timing module, time block, signal generating module, operation control module, can in quantitative simulation examination of visual electro physiology the visual electrophysiology of human eye when being subject to flash stimulation and pictorial stimulus movable, comprise the type of automatic decision optical stimulus signal, and send corresponding standard vision electro physiology analogue signal according to the photostimulation parameter that type and the measurement of photostimulation obtain.By timing module and time block and operation control module and signal generating module separate, precision is high, is convenient to adjustment, is widely used in metering and quality inspection field.
Accompanying drawing explanation
Fig. 1 is the block diagram of human eye visual electrophysiology analog of the present invention;
Fig. 2 is the waveform schematic diagram of flash stimulation;
Fig. 3 is the waveform schematic diagram of pictorial stimulus;
Fig. 4 is the circuit theory diagrams of human eye visual electrophysiology analog of the present invention.
Detailed description of the invention
The embodiment of human eye visual electrophysiology analog of the present invention and method is described in detail below in conjunction with accompanying drawing.
With reference to Fig. 1, human eye vision electro physiology analog provided by the invention, comprises photoelectric conversion module, integral measurement module, shaping pulse module, timing module, time block, signal generating module, operation control module, inputting interface module and display interface module.External optical signals inputs to photoelectric conversion module, photoelectric conversion module, shaping pulse module, timing module, time block, signal generating module are connected successively, photoelectric conversion module is connected with operation control module through integral measurement module, and operation control module is connected with inputting interface module respectively with timing module, time block, signal generating module, display interface module.
Optical stimulus signal is converted into the signal of telecommunication by photoelectric conversion module, export shaping pulse module and integral measurement module to, shaping pulse module exports the square-wave signal corresponding with optical stimulus signal, square-wave signal triggering timing module and time block, timing module judges photostimulation type and controls time block timing from corresponding time point, integral measurement module measures the brightness of optical stimulus signal and the integrated value of time under the Synchronization Control of impulsive measurement module, operation control module receives the parameter setting of inputting interface module input, computing integral measurement result, and export the signal of telecommunication through signal generating module, simultaneously, output state parameter and measurement result are to display interface module.
In analog vision electrophysiologic study, comprise electroretinogram when human eye is subject to flash stimulation and pictorial stimulus and VEP movable.When receiving flash stimulation or pictorial stimulus, measure the flash intensity of flash stimulation, flash of light time-histories, flashing rate and background luminance, the bright lattice brightness of pictorial stimulus, dark lattice brightness and pattern reversal frequency, simultaneously, time delay through presetting sends standard electric signal, and the parameters such as the amplitude of the signal of telecommunication, waveform and time delay all can preset, the parameter corresponding relation between standard electric signal and optical stimulus signal also can preset.Wherein:
Flash intensity: the integration of the luminance vs. time of flash of light, unit is cds/m2;
Flash of light time-histories: the time that flash of light continues, unit is ms;
Flashing rate: the number of times of flash of light in the unit interval, unit is Hz;
Background luminance: the brightness of flash stimulator before stimulation of flashing, unit is cd/m2;
Pattern reversal frequency: in the unit interval, the bright lattice of figure become the number of times that dark lattice become again bright lattice, unit is Hz.
Below the embodiment that the present inventor's eye visual electrophysiology analog provides is described below:
1. the identification of optical stimulus signal type
Human eye vision electro physiology analog identifies photostimulation type based on the time response difference of flash stimulation and pictorial stimulus.The light source no matter flash stimulation of visual electrophysiology instrument adopts is xenon lamp or LED, and its lighting time interval is all no more than 5ms.The frequency of flash stimulation is not more than 30Hz, and pattern reversal frequency is no more than 10Hz, means that interval between interval between double flash of light and pattern reversal is all much larger than 5ms.With reference to Fig. 2 and Fig. 3, shown in be the waveform schematic diagram of the square wave that flash stimulation and pictorial stimulus export after photoelectric conversion module and shaping pulse module, the width utilizing timing module to measure square wave just can judge photostimulation type, thus controls the working method of time block and the output of signal generating module further.
2. the measurement of parameter of glistening
Flash stimulation signal becomes after electric impulse signal through photoelectric conversion module, is received respectively by shaping pulse module and integral measurement module.Shaping pulse module detects the time that pulse signal starts and terminates, and sends the square-wave signal corresponding with it, for controlling integral measurement module.If the high level of luminous corresponding square wave, the low level of the corresponding square wave of the interval between twice luminescence.So, the result that the measurement of integral measurement module obtains between high period is the intensity of flash pulse, and between low period, measure the result obtained be the integrated value of background luminance to the time.Shaping pulse module exports square-wave signal to timing module, and timing module measurement obtains high level time and the low level time of square-wave signal, by measurement result output valve operation control module.High level time is the time-histories of flash stimulation; High level time and low level time sum are the cycle of flash stimulation, get the frequency that inverse is flash stimulation.The background luminance that the measurement of integral measurement module obtains by operation control module is to the integrated value of time divided by interval, and result is background value.If luminous corresponding square wave low level, interval counterparty wave height level, operation principle is similar.
3. the measurement of graphic parameter
Pattern reversal signal is after photoelectric conversion module and shaping pulse module, and the upset change transitions of the bright lattice of figure and dark lattice is corresponding square-wave signal.The edge control integral measurement module of square-wave signal carries out subsection integral measurement.The bright lattice of corresponding diagram shape stimulation and dark trellis state is distinguished when square wave is in high level and low level state.Integral measurement module measures the integrated value of the figure luminance vs. time obtained when square wave is in high level and low level respectively, and timing module measurement obtains high level and low level duration value.Integrated value just can be obtained the brightness of the bright lattice of figure and dark lattice by control algorithm module respectively divided by time of correspondence; High level and low level persistent period are added and can obtain the pattern reversal cycle, get its inverse and be pattern reversal frequency.
4. signal of telecommunication time delay occurs
Flash stimulation signal or pictorial stimulus signal are converted to square-wave signal after photoelectric conversion module and shaping pulse module, and timing module judges the type of optical stimulus signal according to the width of square wave and controls the work of time block according to judged result.If flash stimulation signal, then make time block timing from the moment that each flash of light terminates; If pictorial stimulus signal, then time block timing from the moment of each pattern reversal.The parameter that operation control module can obtain according to photostimulation type and measurement exports control signal generation module and exports corresponding standard vision electro physiology analogue signal, also can export the standard electric such as square wave, sine wave signal according to the input parameter control signal generation module of inputting interface module.After signal generating module is ready, time block reaches timing triggering signal generation module and starts the outputting standard signal of telecommunication.The delay that photoelectric conversion module and shaping pulse module are introduced can control at Microsecond grade, compares with timing module and can ignore with the Millisecond time of time block; The operation of the operation of operation control module and signal generating module and timing module and time block is carried out simultaneously, trigger the outside outputting standard signal of telecommunication by time block again after signal generating module is ready, avoid the delay error of himself running time of uncertain introducing; Timing module and time block independent operating, can ensure the accuracy of time, and adjustment of being more convenient for.
With reference to Fig. 4, in the embodiment of human eye visual electrophysiology analog of the present invention, operation control module adopts model to be the singlechip chip U1 of STC89C51 and model to be the crystal oscillator chip able to programme of SG-8002 to form, and wherein SG-8002 produces frequency is the clock signal of 10MHz.
The reference voltage chip that integral measurement module adopts model is the operational amplifier chip of OPA642, model is ADS804 12 modulus conversion chips, model is TL431 and model are that the singlechip chip U3 of STC89C51 is formed, wherein TL431 is provided for analog-to-digital reference voltage to ADS804, and singlechip chip U3 reads analog-digital conversion data and carries out calculating and result exported.
The scaling circuit that the operational amplifier chip that shaping pulse module is OP07AJ by two models is formed and model are that the NAND gate chip U12 of 74LS312 is formed, and export after the signal inversion that wherein second level operational amplification circuit exports by 74LS312.
Timing module adopts model to be the counter chip of 74LS90, model is the counter chip U7 of 82C54, model is monostable flipflop chip U15 and U17 of 74LS121, the 74V1T32 that model is or door chip, model is the NAND gate chip U10 of 74LS132, model is forming with door chip of LN74SZ08, wherein system 10MHz clock signal is converted to 2MHz clock signal and is supplied to counter chip U7 by 74LS90, with the counter chip U14 in time block, two monostable flipflop chips detect rising edge and the trailing edge output positive pulse of input signal respectively, enumerator 0 sum counter 1 of counter chip U7 measures high level time and the high level time of input signal respectively, enumerator 2 measures the width of square wave for judging the type of optical stimulus signal, the pulse signal synthesis that two 74LS121 export by 74V1T32, 74LS312 is by anti-phase for the output signal OUT2 of the enumerator 2 in 74LS90 rear output, LN74SZ08 outputs signal to operation control module.
Time block employing model is that the counter chip U14 of 82C54 is formed, and wherein the enumerator 0 of counter chip U14 is for controlling optical stimulus signal and sending the time delay between the signal of telecommunication.
The annexation of modules is: the data bit pin of the singlechip chip U1 in operation control module and control bit pin are connected with display interface module with the counter chip in time block, signal generating module, inputting interface module with the singlechip chip U3 of integral measurement module, timing module respectively with bus mode; The output pin of photoelectric detection module is connected with the in-phase input end of the in-phase input end of the operational amplifier chip in shaping pulse module with the operational amplifier chip in integral measurement module through resistance respectively; TXD with the RXD pin of the single-chip microcomputer U3 in integral measurement module is corresponding with RXD and the TXD pin of the single-chip microcomputer U1 in operation control module to be connected; The 2Y pin of the NAND gate chip in shaping pulse module is connected with the P2.1 pin of the singlechip chip U3 in integral measurement module, correspondingly with 4A and the 4B pin of the B pin of the monostable flipflop chip U15 of in timing module and A1 and the A2 pin of another monostable flipflop chip U17, the enumerator 0 of counter chip U7 and GATE0 pin, NAND gate chip U10 connects; 1Y pin that is in timing module or door chip is connected with the GATE0 pin of the counter chip U14 in time block, A1 with the A2 pin of monostable flipflop chip U15 is connected with the P2.0 pin of singlechip chip U1; The OUT0 pin of the chip U14 in time block is connected with signal generating module.
In the embodiment of human eye visual electrophysiology analog of the present invention, working method is as follows:
After the start of human eye vision electro physiology analog, control module wherein exports the status information of device to display interface module, the parameter that reception user is inputted by inputting interface module, setting timing module and the timing time of time block and the output waveform parameter of signal generating module, or keep the parameter state of acquiescence.
1) when photoelectric conversion module receives a flash stimulation signal, the outfan of photoelectric conversion module exports an electric impulse signal consistent with flash stimulation impulse waveform, export shaping pulse module to, shaping pulse module converts the voltage pulse signal after amplification to a square-wave signal, the width of square-wave signal is identical with the width of flash pulse, the beginning of its rising edge and trailing edge or trailing edge and the corresponding flash signal of rising edge difference and finish time, the high voltage of square-wave signal and low-voltage or low-voltage and high voltage corresponding digital high and low level respectively.
Square-wave signal exports integral measurement module, timing module and time block to simultaneously; Square-wave signal controls integral measurement module and starts the time that anomalous integral terminates integration, and integral measurement module measures the integrated value of the luminance vs. time in flash duration, i.e. flash intensity value, and exports result to operation control module; Before square-wave signal, under edging trigger, timing module and time block start timing, and timing module measures the width of square wave, time-histories of namely glistening; The square width that timing module measurement obtains is less than 5ms, and timing module internal logic judges that optical stimulus signal is flash stimulation, sends signal make time block reset reset reclocking to time block; Timing module exports photostimulation type, flash of light time-histories measurement result to operation control module; Operation control module calculates measurement result and exports display interface module to; Operation control module sends corresponding status signal according to flash of light parameter measurements to signal generating module, and signal generating module is ready; Time block, after the time delay preset, sends signal to signal generating module, makes signal generating module by the electrical signal output interface outputting standard signal of telecommunication, and time block reset itself resets simultaneously; Signal generating module exports the signal of telecommunication of the waveform of the visual electrophysiology analogue signal corresponding with flash of light parameter or other types as sine wave, square wave, sawtooth waveforms etc.
Under the back edge of square-wave signal triggers, timing module restarts timing, and integral measurement module restarts to measure background luminance to the integration of time, until next flash stimulation signal occurs; Timing module and integral measurement module export measurement result to operation control module, and operation control module divided by the result of timing module, obtains background luminance by the result of integral measurement module; To the adjacent twice measurement result summation of timing module, obtain the cycle of flash stimulation, get its inverse and be flashing rate; If photostimulation is single flash operation, then timing module and integral measurement module can carry out timing and measurement according to the maximum age time preset (being greater than the cycle of repeatedly glistening, as 100ms), without the need to waiting for next flash stimulation signal.
When photoelectric conversion module receives next flash stimulation signal, the modules of device repeats above-mentioned flow process and starts working.
2) when photoelectric conversion module receives the signal that a pictorial stimulus is bright lattice by bright lattice upset for dark lattice or dark lattice upset, the outfan output voltage of photoelectric conversion module synchronously declines or rise with pattern reversal, export the amplitude of the signal of telecommunication after signal amplification module amplifies, export shaping pulse module to, shaping pulse module converts the change of the signal of telecommunication to a step signal, trailing edge or the rising edge of step signal are synchronous with pattern reversal, the digital high of the high voltage of step signal and low-voltage or low-voltage and the high voltage corresponding timing module of difference and time block input and low level.
Step signal exports integral measurement module, timing module and time block to simultaneously; Start integral measurement at the triggering lower integral measurement module of this step signal, under the triggering of step signal, timing module and time block start timing; After postponing after a while, the pattern reversal signal that photoelectric conversion module receives is contrary with a upper pattern reversal signal, after signal amplification module and shaping pulse module, shaping pulse module exports a rightabout step signal, a complete square wave is formed with a upper step signal, integral measurement result is exported to operation control module at the triggering lower integral measurement module of this step signal, timing module exports measure of time result to operation control module, and integral measurement module resets and restarts to measure.
The square width that timing module measurement obtains is greater than 5ms, and timing module internal logic judges that optical stimulus signal is pictorial stimulus, sends the signal indicating photostimulation type to control module, and timing module reset itself resets and restarts timing; Timing module exports photostimulation type, measure of time result to operation control module; Operation control module calculates the brightness of the bright lattice of measured figure or dark lattice according to the measurement result of integral measurement module and timing module, result of calculation is exported to display interface module; Operation control module sends corresponding status signal according to graphic parameter measurement result to signal generating module, and signal generating module is ready; Time block, after the time delay preset, sends signal to signal generating module, makes signal generating module export the signal of telecommunication by electrical signal output interface, and time block reset itself resets simultaneously; Signal generating module exports the signal of telecommunication of the waveform of the visual electrophysiology analogue signal corresponding with graphic parameter or other types as sine wave, square wave, sawtooth waveforms etc.
When receiving next pattern reversal signal to photoelectric conversion module, the measurement of integral measurement module obtains the integrated value of the luminance vs. time of the dark lattice of figure or bright lattice, and its persistent period is starved in timing module measurement; Integral measurement module and timing module export measurement result to operation control module; The measurement result of integral measurement module is obtained the brightness value of the dark lattice of figure or bright lattice by operation control module divided by the measurement result of timing module, the summation of the measurement result of adjacent twice of timing module is obtained the cycle of pattern reversal signal, get its inverse and be pattern reversal frequency; Operation control module exports result of calculation to display interface module.
When photoelectric conversion module receives next pattern reversal signal, the modules of device repeats above-mentioned flow process and starts working.Specific works process is as follows:
After the start of human eye vision electro physiology analog, the single-chip microcomputer of operation control module is initialized modules respectively by bus, export the status information of device to display interface module, receive the parameter that user is inputted by inputting interface module, working method is as follows:
After start, the singlechip chip of operation control module initializes each chip, wherein the initial count value of enumerator 0 sum counter 1 of the counter chip U7 in timing module is set to 0 (corresponding maximum count value), according to input parameter, the enumerator 2 in timing module is set as differentiating that photostimulation type is the time parameter of flash stimulation, as 5ms, the enumerator 0 of the counter chip U14 in time block is set as receiving photostimulation to the time delay sending the signal of telecommunication, as 10ms, enumerator 0 sum counter 1 in timing module works in mode 4, in timing module, in the enumerator 2 of U7 and time block, the enumerator 0 of U14 works in mode 5, A1 and the A2 pin of monostable flipflop chip U15 is arranged to 0, makes it be in the normal operating conditions detecting rising edge, when photoelectric conversion module receives optical stimulus signal, the outfan of photoelectric conversion module exports an electric impulse signal consistent with optical stimulus signal waveform, pulse signal, after the two-stage amplifying circuit of integral measurement module amplifies, exports a square-wave signal at the 2Y pin of NAND gate chip U12, square-wave signal exports integral measurement module, timing module and time block simultaneously, output of pulse signal is to the input of integral measurement module amplifying circuit, square-wave signal exports the P2.2 pin of the singlechip chip U3 of integral measurement module to, pulse signal is converted to digital signal through modulus conversion chip ADS804 again after amplifying, input singlechip chip U3, singlechip chip U3 calculates the integrated value of the luminance vs. time under high level and low level state respectively according to the level state of P2.2 pin, square wave through two monostable flipflops and one be converted into two short pulses behind the door, the rising edge of the corresponding square wave of difference and trailing edge, export the GATE0 pin of the counter chip 82C54 (U14) of time block to, enumerator 0 subtraction count from preset value, a negative pulse is exported to signal generating module at OUT0 pin, control signal generation module output signal at the end of counting, square wave exports GATE0 pin and the GATE2 pin of the counter chip 82C54 (U7) of timing module to, GATE1 pin is exported to after anti-phase, enumerator 0 counts when the high level of square wave, enumerator 1 counts when the low level of square wave, count status signal OUT0 and OUT1 exports the singlechip chip U1 of operation control module to, singlechip chip U1 reads count value, enumerator 2 is for judging the type of optical stimulus signal, rising edge through square wave triggers and starts counting, it is 0 that counting terminates front OUT2 output, and it is 1 that counting terminates rear OUT2 output.
(1) if optical stimulus signal is flash signal, then before enumerator 2 counting of the counter chip U7 of timing module terminates, monostable flipflop chip U17 detects the square wave trailing edge of corresponding flash of light done state thus exports a positive pulse, the singlechip chip U1 of a positive pulse to operation control module is exported after NAND gate chip U10, after singlechip chip U1 receives positive pulse, A1 and the A2 pin of monostable flipflop chip U15 is put 1, monostable flipflop chip U15 no longer detects the rising edge of square wave, the enumerator 0 of the counter chip U14 of time block is only subject to the triggering of square wave trailing edge, thus realize the function of the only time delay output signal of telecommunication after terminating at flash stimulation.The result that single-chip microcomputer obtains according to timing module and the measurement of integral measurement module calculates, obtain the parameters such as flash intensity value, flash duration, background value, flashing rate respectively, export display interface module to, and send corresponding instruction to signal generating module according to result, export the signal of telecommunication corresponding with it.If photostimulation is single flash operation, then the enumerator 1 of timing module automatically terminates after maximum subtraction count to 0, and integral measurement module correspondingly stops integration, without the need to waiting for next flash stimulation signal.When photoelectric conversion module receives next flash stimulation signal, the modules of device repeats above-mentioned flow process and starts working.
(2) if optical stimulus signal is figure signal, then after enumerator 2 counting of the counter chip U7 of timing module terminates, monostable flipflop chip U17 just detects that square wave trailing edge exports pulse, and now the enumerator 2 of counter chip U7 exports OUT2 pin is 1, NOT gate chip U10 exports as remaining 0, singlechip chip U1 attonity, A1 and the A2 pin of monostable flipflop chip U15 remains 0, monostable flipflop chip U15 normally can detect the rising edge of square wave, the enumerator 0 of the counter chip U14 of time block is subject to the triggering of square wave rising edge and trailing edge simultaneously, thus realize the equal triggering signal generation module time delay when the dimmed lattice of bright lattice of pictorial stimulus or dark lattice brighten lattice and export the signal of telecommunication.The result that single-chip microcomputer obtains according to timing module and the measurement of integral measurement module calculates, obtain bright lattice brightness value, the dark parameter such as lattice brightness value and pattern reversal frequency respectively, export display interface module to, and send corresponding instruction to signal generating module according to result, export the signal of telecommunication corresponding with it.When photoelectric conversion module receives next pattern reversal signal, the modules of device repeats above-mentioned flow process and starts working.
The analogy method of human eye vision electro physiology analog provided by the invention, comprises the steps:
Step 1, is converted into the signal of telecommunication that amplitude is directly proportional to the brightness of optical stimulus signal by optical stimulus signal, and carries out integral measurement to this signal of telecommunication;
Step 2, identifies the type of optical stimulus signal, integral measurement signal is converted to square-wave signal, by the width of timing measuring square wave, comes identification blink stimulus signal and pictorial stimulus signal, if flash stimulation signal, perform next step with its time property difference; If pictorial stimulus signal, perform step 4;
Step 3, if the high level of luminous corresponding square wave, the low level of the corresponding square wave of the interval between twice luminescence, so, between high period, integral measurement result is as the intensity of flash pulse, and the integrated value of integral measurement result luminance vs. time as a setting between low period, the high level time of timing measuring result is as the time-histories of flash stimulation, high level time and low level time sum are as the cycle of flash stimulation, get the frequency as flash stimulation reciprocal, background luminance divided by interval brightness value as a setting, performs step 5 to the integrated value of time;
Step 4, subsection integral measurement is carried out with the edge of square-wave signal, square wave is in the bright trellis state of the corresponding pictorial stimulus of high level, square wave is in the dark trellis state of the corresponding pictorial stimulus of low level, carry out the integrated value that integral measurement obtains figure luminance vs. time when square wave is in high level and low level respectively, timing measuring obtains time value that high level continues and the time value that low level continues, and by two integrated values respectively divided by the corresponding time, and respectively as the brightness of the bright lattice of figure and dark lattice, the time value that the time value continued by high level and low level continue was added as the pattern reversal cycle, get its inverse as pattern reversal frequency, perform next step,
Step 5, inputting interface input setup parameter, integral measurement and timing measuring and operation result thereof export display interface to.Human eye visual electrophysiology analog of the present invention and method, use same set of integral measurement module, shaping pulse module and timing module to achieve the measurement of the flash intensity of flash stimulation, the bright lattice brightness of glisten time-histories, flashing rate, background luminance and pictorial stimulus, dark lattice brightness, pattern reversal frequency, automatically export corresponding standard electric signal according to the type of optical stimulus signal, automatically export corresponding standard electric signal according to the parameter of optical stimulus signal simultaneously.And adopt external definition module to achieve photostimulation to signal of telecommunication output time adjustable delay.
Embodiment recited above is only be described the preferred embodiment of the present invention, not limits the spirit and scope of the present invention.Under the prerequisite not departing from design concept of the present invention; the various modification that this area ordinary person makes technical scheme of the present invention and improvement; all should drop into protection scope of the present invention, the technology contents of request protection of the present invention, all records in detail in the claims.
Claims (3)
1. a human eye vision electro physiology analog, it is characterized in that: comprise photoelectric conversion module, integral measurement module, shaping pulse module, timing module, time block, signal generating module, operation control module, inputting interface module and display interface module, wherein: external optical signals inputs to described photoelectric conversion module, described photoelectric conversion module, shaping pulse module, timing module, time block, signal generating module is connected successively, described photoelectric conversion module is connected with described operation control module through described integral measurement module, described operation control module and described timing module, time block, signal generating module, display interface module is connected respectively with inputting interface module, optical stimulus signal is converted into the signal of telecommunication by described photoelectric conversion module, export described shaping pulse module and integral measurement module to, described shaping pulse module exports the square-wave signal corresponding with optical stimulus signal, described square-wave signal triggers described timing module and time block, described timing module judges photostimulation type and controls the timing from corresponding time point of described time block, described integral measurement module measures the brightness of optical stimulus signal and the integrated value of time under the Synchronization Control of described shaping pulse module, described operation control module receives the parameter setting of described inputting interface module input, computing integral measurement result, and export the signal of telecommunication through described signal generating module, simultaneously, output state parameter and measurement result are to described display interface module.
2. human eye vision electro physiology analog according to claim 1, is characterized in that: wherein said operation control module adopts model to be the singlechip chip U1 of STC89C51 and model to be the crystal oscillator chip able to programme of SG-8002 to form; The reference voltage chip that integral measurement module adopts model is the operational amplifier chip of OPA642, model is ADS804 12 modulus conversion chips, model is TL431 and model are that the singlechip chip U3 of STC89C51 is formed; The scaling circuit that the operational amplifier chip that shaping pulse module is OP07AJ by two models is formed and model are that the NAND gate chip U12 of 74LS312 is formed; The monostable flipflop chip U15 that timing module adopts model is the counter chip of 74LS90, model is 82C54 counter chip U7, model is 74LS121 and monostable flipflop chip U17, model be 74V1T32's or door chip, model be the NAND gate chip U10 of 74LS132 and model be forming with door chip of LN74SZ08; Time block employing model is that the counter chip U14 of 82C54 is formed; Wherein: the data bit pin of the singlechip chip U1 in operation control module and control bit pin are connected with display interface module with the counter chip U14 in time block, signal generating module, inputting interface module with the counter chip U7 in the singlechip chip U3 of integral measurement module, timing module respectively with bus mode; The output pin of photoelectric detection module is connected with the in-phase input end of the in-phase input end of the operational amplifier chip in shaping pulse module with the operational amplifier chip in integral measurement module through resistance respectively; TXD with the RXD pin of the singlechip chip U3 in integral measurement module is corresponding with RXD and the TXD pin of the singlechip chip U1 in operation control module to be connected; The 2Y pin of the NAND gate chip in shaping pulse module is corresponding with 4A and the 4B pin of the B pin of monostable flipflop chip U15 in the P2.1 pin of the singlechip chip U3 in integral measurement module, timing module, the enumerator 0 of counter chip U7 and GATE0 pin and NAND gate chip U10 respectively to be connected; 1Y pin that is in timing module or door chip is connected with the GATE0 pin of the counter chip U14 in time block, A1 with the A2 pin of monostable flipflop chip U15 is connected with the P2.0 pin of singlechip chip U1; The OUT0 pin of the chip U14 in time block is connected with signal generating module.
3. adopt an analogy method for the human eye vision electro physiology analog described in claim 1 or 2, it is characterized in that: the method comprises the steps:
Step 1, is converted into the signal of telecommunication that amplitude is directly proportional to the brightness of optical stimulus signal by optical stimulus signal, and carries out integral measurement to this signal of telecommunication;
Step 2, identifies the type of optical stimulus signal, integral measurement signal is converted to square-wave signal, by the width of timing measuring square wave, comes identification blink stimulus signal and pictorial stimulus signal, if flash stimulation signal, perform next step with its time property difference; If pictorial stimulus signal, perform step 4;
Step 3, if the high level of luminous corresponding square wave, the low level of the corresponding square wave of the interval between twice luminescence, so, between high period, integral measurement result is as the intensity of flash pulse, and the integrated value of integral measurement result luminance vs. time as a setting between low period, the high level time of timing measuring result is as the time-histories of flash stimulation, high level time and low level time sum are as the cycle of flash stimulation, get the frequency as flash stimulation reciprocal, background luminance divided by interval brightness value as a setting, performs step 5 to the integrated value of time;
Step 4, subsection integral measurement is carried out with the edge of square-wave signal, square wave is in the bright trellis state of the corresponding pictorial stimulus of high level, square wave is in the dark trellis state of the corresponding pictorial stimulus of low level, carry out the integrated value that integral measurement obtains figure luminance vs. time when square wave is in high level and low level respectively, timing measuring obtains time value that high level continues and the time value that low level continues, and by two integrated values respectively divided by the corresponding time, and respectively as the brightness of the bright lattice of figure and dark lattice, the time value that the time value continued by high level and low level continue was added as the pattern reversal cycle, get its inverse as pattern reversal frequency, perform next step,
Step 5, inputting interface input setup parameter, integral measurement and timing measuring and operation result thereof export display interface to.
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