CN103987370A - Compositions for enhancing nail health - Google Patents

Compositions for enhancing nail health Download PDF

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CN103987370A
CN103987370A CN201280059691.1A CN201280059691A CN103987370A CN 103987370 A CN103987370 A CN 103987370A CN 201280059691 A CN201280059691 A CN 201280059691A CN 103987370 A CN103987370 A CN 103987370A
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semen
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J·G·沃尔特
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Allergan Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q3/00—Manicure or pedicure preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/062—Oil-in-water emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Oil, Petroleum & Natural Gas (AREA)
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  • Dispersion Chemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

The present invention is directed to compositions and methods for enhancing the health of nails and cuticles in a mammal, including humans. The compositions may be administered topically to the nail bed, nail matrix and cuticle in an amount effective to enhance nail health. The composition is also effective in strengthening and growing nails.

Description

For promoting the compositions of fingernail health
Related application
Present patent application requires the rights and interests of the U.S. Provisional Patent Application serial number 61/543,758 of submission on October 5th, 2011, and this temporary patent application is incorporated herein by reference.
Technical field
The application relates to for promoting the compositions that fingernail and horny layer are healthy and grow.
Background of invention
The fingernail that comprises toenail and fingernail mainly consists of keratin.Fingernail and toenail are the tissues of living.Fingernail forms inwardly growing and be called in the skin bag of nail matrix.This region produces fingernail and also referred to as nail root.The skin of matrix comprises the keratic specialized cell that formation grows with nail plate form.
Nail plate is commonly referred to fingernail or toenail.
Nail matrix is finger tissue or the toe tissue of supporting fingernail.Fingernail is in people's lasting growth in life, and growth average speed is approximately monthly 3 millimeters.Fingernail may need 3 to completely again growing over 6 months, and toenail needs about 12 to 18 months.The actual speed of growth depends on age, sex, season, sports level, diet and inherited genetic factors.
Fingernail and horny layer ill-health can cause onychorrhexis syndrome.The syndromic feature of onychorrhexis can be asperities first (trachyonychia) (for example rough surface), stratiform onycholysis (lamellar onychoschizia) (for example horizontal slice/peel off) and/or onychorrhexis (onycohrrhexis) (for example longitudinal cracking of distal side edge or division).In addition, onychorrhexis syndrome also can cause fingernail frangible, lack thickness and/or nail growth bad.Onychorrhexis syndrome part is due to due to the chronic inflammatory disease of nail matrix.
For for example, treatment because of the various disease conditions fingernail that for example anemia, vitamin or mineral deficiency, onychorrhexis, nephropathy and hepatopathy, psoriasis, angiopathy (Raynaud disease) and heart disease cause and toenail problem often cause nail growth bad, occur flute stricture of vagina (vertical trench), depression (pitting), cracking, band, shortage thickness and intensity, shortage smoothness, be easy to tear and syndromic other symptoms of onychorrhexis.
Although developed multiple therapy methods for example use fingernail strengthening and sclerosis polishing agent, albumen elixir for example bovine collagen protein emulsion, polytypely wear protectiveness fingernail lid and other similar products, yet still in the urgent need to can really recovering the Therapeutic Method of fingernail and horny layer health.For improving the problem of the Therapeutic Method of fingernail health, is at present that they are in fact mainly cosmetics, most invalid, and conventionally by general absorb (biological example element and silicon) and time-consuming.Need really to make fingernail and horny layer return to the compositions of its natural health state.
Summary of the invention
The present invention relates to that the fingernail of the mammal that comprises people is healthy, horny layer is healthy and/or the compositions of nail growth and method for promoting.Certain embodiments of the present invention relate to the syndromic compositions of the onychorrhexis being used for the treatment of in the mammal that comprises people and method.In certain embodiments, said composition comprises one or more immunomodulators, such as immunosuppressant.In other embodiments, said composition comprises one or more anti-inflammatory agents.In also having other embodiments, the combination that said composition comprises one or more immunomodulators and one or more anti-inflammatory agents.
Said composition can local application to nail matrix, nail matrix, fingernail end or tip and horny layer, its amount can be for example by thickening, strengthen fingernail and horny layer and/or making it smooth and promote fingernail health by treatment onychorrhexis syndrome in some embodiments and/or horny layer is healthy.In certain embodiments, said composition can local application to nail matrix, nail matrix, fingernail end or tip and horny layer, its amount can effectively be promoted nail growth.Using of said composition can be for once a day, one day twice, one day three times, one day four times, one day five times, one day six times, weekly, biweekly, Wednesday time, a Thursday time, a Friday time or a Saturday time.Said composition can be contained in test kit, and this test kit comprises bottle or allotter and the applicator (for example applicator brush) that compositions is housed.
Compositions of the present invention includes but not limited to: emulsion, microemulsion, reversed-phase emulsion, solution, colloid, suspension, dispersion liquid, gel, paste and polishing agent.In certain embodiments, said composition comprises the reactive compound that at least one is selected from immunomodulator (for example ciclosporin) and antiinflammatory (for example ketorolac).In at least one embodiment, said composition comprises Ciclosporin A.In certain embodiments, the combination that said composition comprises ciclosporin and ketorolac.In other embodiments, said composition comprises at least one retinoid, such as tazarotene.In certain embodiments, said composition comprises biotin and/or silicone.
Certain embodiments of the present invention relate to the O/w emulsion that optionally comprises reactive compound, and wherein emulsion can comprise at least one oil and/or surfactant.An embodiment, this emulsion comprise Oleum Ricini, polysorbate80, glycerol, NaOH and optionally comprise polyacrylate (such as carbomer and ) and other other compositions.
In at least one embodiment of the present invention, the carboxymethyl cellulose that compositions comprises 0.5%w/v, the glycerol of 0.9%w/v, 0.25% carnitine and erithritol and the pyrite (purite) of 0.25%w/v.Some other embodiment of the present invention are described in the following embodiments, and it optionally omits or comprises Ciclosporin A:
Oleum Ricini or another kind of oil or another kind of hydrophobic components, for example vegetable oil, animal oil, mineral oil, artificial oil, higher fatty acids glyceride etc. and composition thereof (some of them " specific embodiment " part is below listed) can exist with following concentration: 1.25%w/v in compositions, 0.01%-w/v – 10.0%w/v, 0.1%w/v – 5.0%w/v, 0.1%w/v – 4.0%w/v, 0.1%w/v – 3.0%w/v, 0.1%w/v – 2.0%w/v, 0.1%w/v – 1.0%w/v, 0.1%w/v – 0.9%w/v, 0.1%w/v – 0.8%w/v, 0.1%w/v – 0.8%w/v, 0.1%w/v – 0.7%w/v, 0.1%w/v – 0.6%w/v, 0.1%w/v – 0.5%w/v, 0.1%w/v – 0.4%w/v, 0.1%w/v – 0.3%w/v, 0.1%w/v – 0.2%w/v, 0.09%-0.1%w/v, 0.08%-0.1%w/v, 0.07%-0.1%w/v, 0.06%-0.1%w/v, 0.05%-0.1%w/v, 0.04%-0.1%w/v, 0.03%-0.1%w/v, 0.02%-0.1%w/v, 0.01%-0.1%w/v, 0.01 – 0.09%, 0.01 – 0.08%, 0.01 – 0.07%w/v, 0.01-0.06%w/v, 0.01 – 0.05%w/v, 0.01 – 0.04%w/v, 0.01 – 0.03%w/v, 0.01-0.02%w/v, 0.01 – 0.0125%w/v, and 0.05%w/v – 5.0%w/v most preferably.
Polysorbate80 or another kind of suitable surfactant, for example alcohol (comprising carboxylation and ethoxylated alcohol), amine oxide, block polymer, fatty acid (comprising carboxylic fatty acids), ethoxylated alkylphenol, ethoxylated fat ester, glyceride, lanoline radical derivative, lignin derivative, methyl ester, monoglyceride and triglyceride, Polyethylene Glycol, polymeric surfactant, propoxylation and ethoxylated fatty acid, alcohol, or alkyl phenol, protein-based surfactant, sucrose and glucose ester and derivant (some of them " specific embodiment " part is below listed), can exist with the concentration of measuring as follows: 1.0%w/v or 0.01%-w/v – 10.0%w/v in certain embodiments, 0.1%w/v – 5.0%w/v, 0.1%w/v – 4.0%w/v, 0.1%w/v – 3.0%w/v, 0.1%w/v – 2.0%w/v, 0.1%w/v – 1.0%w/v, 0.1%w/v – 0.9%w/v, 0.1%w/v – 0.8%w/v, 0.1%w/v – 0.7%w/v, 0.1%w/v – 0.6%w/v, 0.1%w/v – 0.5%w/v, 0.1%w/v – 0.4%w/v, 0.1%w/v – 0.3%w/v, 0.1%w/v – 0.2%w/v, 0.09%-0.1%w/v, 0.08%-0.1%w/v, 0.07%-0.1%w/v, 0.06%-0.1%w/v, 0.05%-0.1%w/v, 0.04%-0.1%w/v, 0.03%-0.1%w/v, 0.02%-0.1%w/v, 0.01%-0.1%w/v, 0.01 – 0.09%, 0.01 – 0.08%, 0.01 – 0.07%w/v, 0.01-0.06%w/v, 0.01 – 0.05%w/v, 0.01 – 0.04%w/v, 0.01 – 0.03%w/v, 0.01-0.02%w/v and 0.01 – 0.0125%w/v.
Pemulen TR-2 or carbomer934 or other polymer or acrylate copolymer well known in the art can be measured existence: .05%w/w or 0.01%-w/v – 10.0%w/v as follows, 0.1%w/v – 5.0%w/v, 0.1%w/v – 4.0%w/v, 0.1%w/v – 3.0%w/v, 0.1%w/v – 2.0%w/v, 0.1%w/v – 1.0%w/v, 0.1%w/v – 0.9%w/v, 0.1%w/v – 0.8%w/v, 0.1%w/v – 0.7%w/v, 0.1%w/v – 0.6%w/v, 0.1%w/v – 0.5%w/v, 0.1%w/v – 0.4%w/v, 0.1%w/v – 0.3%w/v, 0.1%w/v – 0.2%w/v, 0.09%-0.1%w/v, 0.08%-0.1%w/v, 0.07%-0.1%w/v, 0.06%-0.1%w/v, 0.05%-0.1%w/v, 0.04%-0.1%w/v, 0.03%-0.1%w/v, 0.02%-0.1%w/v, 0.01%-0.1%w/v, 0.01 – 0.09%, 0.01 – 0.08%, 0.01 – 0.07%w/v, 0.01-0.06%w/v, 0.01 – 0.05%w/v, 0.01 – 0.04%w/v, 0.01 – 0.03%w/v, 0.01-0.02%w/v and 0.01 – 0.0125%w/v.
Glycerol and mannitol or other tension regulators known in the art can be measured existence as follows: be respectively 1.0%w/w or 2.0%w/w, or 0.01%-w/v – 10.0%w/v, 0.1%w/v – 5.0%w/v, 0.1%w/v – 4.0%w/v, 0.1%w/v – 3.0%w/v, 0.1%w/v – 2.0%w/v, 0.1%w/v – 1.0%w/v, 0.1%w/v – 0.9%w/v, 0.1%w/v – 0.8%w/v, 0.1%w/v – 0.7%w/v, 0.1%w/v – 0.6%w/v, 0.1%w/v – 0.5%w/v, 0.1%w/v – 0.4%w/v, 0.1%w/v – 0.3%w/v, 0.1%w/v – 0.2%w/v, 0.09%-0.1%w/v, 0.08%-0.1%w/v, 0.07%-0.1%w/v, 0.06%-0.1%w/v, 0.05%-0.1%w/v, 0.04%-0.1%w/v, 0.03%-0.1%w/v, 0.02%-0.1%w/v, 0.01%-0.1%w/v, 0.01 – 0.09%, 0.01 – 0.08%, 0.01 – 0.07%w/v, 0.01-0.06%w/v, 0.01 – 0.05%w/v, 0.01 – 0.04%w/v, 0.01 – 0.03%w/v, 0.01-0.02%w/v and 0.01 – 0.0125%w/v.
In one embodiment, emulsion comprises: the mannitol of the Oleum Ricini of the polysorbate80 of 1.0%w/w, the glycerol of 0.05%w/w, 1.0%w/w, pemulin TR-2, the 1.5%w/w of 0.08%w/w, pH is adjusted to 7.4 sodium hydroxide and purified water.Another embodiment comprises the polysorbate80 of the emulsion that contains following composition: 1.0%w/w, the mannitol of pemulin TR-2, the 2.0%w/w of the Oleum Ricini of the glycerol of 1.0%w/w, 1.25%w/w, 0.05%w/w, pH is adjusted to 7.4 sodium hydroxide and purified water.Another kind of emulsion comprises: the mannitol of the Oleum Ricini of the polysorbate80 of 1.5%w/w, the glycerol of 0.05%w/w, 0.05%w/w, pemulin TR-2, the 1.5%w/w of 0.08%w/w, pH is adjusted to 7.4 sodium hydroxide and purified water.Another kind of emulsion of the present invention comprises: the mannitol of the Oleum Ricini of the polysorbate80 of 1.2%w/w, the glycerol of 1.0%w/w, 1.50%w/w, pemulin TR-2, the 2.5%w/w of 0.05%w/w, pH is adjusted to 7.4 sodium hydroxide and purified water.Another kind of emulsion of the present invention comprises: the mannitol of the Oleum Ricini of the polysorbate80 of 0.5%w/w, the glycerol of 1.0%w/w, 1.25%w/w, pemulin TR-2, the 1.0%w/w of 0.05%w/w, pH is adjusted to 7.4 sodium hydroxide and purified water.
Certain embodiments of the present invention comprise:
Embodiment 1: a kind of for promoting fingernail health human or animal, promoting the compositions that horny layer is healthy and/or promote nail growth, said composition comprises immunomodulator and/or antiinflammatory in O/w emulsion, and wherein said compositions part is applied to described human or animal's fingernail.
Embodiment 2: the compositions of embodiment 1, wherein immunomodulator is ciclosporin.
Embodiment 3: embodiment 1 or 2 compositions, wherein emulsion comprises Oleum Ricini and surfactant.
Embodiment 4: the compositions of embodiment 1-3 any one, wherein emulsion comprises Ciclosporin A derivant or fragment.
Embodiment 5: the compositions of embodiment 1, also comprises antiinflammatory.
Embodiment 6: the compositions of embodiment 5, wherein said antiinflammatory is ketorolac.
Embodiment 7: the compositions of embodiment 1, wherein emulsion also comprises the component that at least one is selected from glycerol, polysorbate80 and carbomer (for example carbomer934).
Embodiment 8: the compositions of embodiment 1, the polysorbate80 that wherein compositions comprises 1.0%w/v, the glycerol of 2.2%w/v, the pemulin of the Oleum Ricini of 1.25%w/v, 0.05%w/v.
Embodiment 9: the compositions of embodiment 1, the polysorbate80 that wherein compositions comprises 0.5%-1.5%w/w, the glycerol of 0.5%-1.5%w/w, the carbomer934 of the Oleum Ricini of 0.5%-1.5%w/w, 0.05%-0.1%w/w and mannitol.
Embodiment 10: the compositions of embodiment 1-9 any one, wherein compositions applies at least one times every day.
Embodiment 11: the compositions of embodiment 1-10 any one, it also can be used for treatment and is selected from following toenail or fingernail obstacle: onychorrhexis syndrome, fingernail psoriasis, psoriasis onychodystrophy, onychorrhexis syndrome, first length and thickness increase, onychitis, curved first disease, onychoatrophy, ingrowing nail, Onychodystrophy, onychogryphosis, onycholysis, onychomadesis, onychauxis, tinea unguium, onychorrhexis, tinea unguium, onychophosis, onychoptosis, paronychia, pseudomonas infection, pterygium and pterygium inversum unguis, spoon nail, hematoma under nail or other wounds to fingernail, folic acid deficiency, leukonychia, refer to chatelain's syndrome, melanonychia, hypoproteinosis, onychorrhexis and first are peeled off, the fingernail of methyl methacrylate damage, vitamin C deficiency, avitaminosis, first tinea alba, the first relevant to lichen planus is thin soft, Raynaud disease, relevant to rheumatoid arthritis bleeds, Beau lines, poisoning relevant Michaelis line to some type.
Embodiment 12: the compositions of embodiment 1, wherein said grease separation is from Oleum Anisi Stellati; Oleum Ricini; Oleum Caryophylli; Oleum Cinnamomi; Oleum Cinnamomi; The oil of proportion between 0.90 and 0.95; Almond oil; Semen Maydis oil; Oleum Arachidis hypogaeae semen; Oleum Gossypii semen; Safflower oil; Oleum maydis; Semen Lini oil; Oleum Brassicae campestris; Soybean oil; Olive oil; Caraway seed oil; Oil of rosemary; Oleum Arachidis hypogaeae semen; Oleum menthae; Oleum helianthi; Eucalyptus oil; Oleum sesami; The oil that proportion is less than 0.9; Mineral oil; Fructus Coriandri oil; Oleum lavandula angustifolia; Citronella oil; Oleum juniperi e baccarae; Fructus Citri Limoniae oil; Orange oil; Sage oil; Semen Myristicae oil; With tea tree oil or its mixture.
Embodiment 13: the compositions of embodiment 1, wherein said O/w emulsion also comprises and is selected from following surfactant: polysorbate80, carboxylation and ethoxylated alcohol, amine oxide, block polymer, the fatty acid that comprises carboxylic fatty acids, ethoxylated alkylphenol, ethoxylated fat ester, glyceride, lanoline radical derivative, lignin derivative, methyl ester, monoglyceride and triglyceride, Polyethylene Glycol, polymeric surfactant, propoxylation and ethoxylated fatty acid, alcohol, or alkyl phenol, protein-based surfactant, sucrose and glucose ester and derivant thereof or mixture.
Embodiment 14: the compositions of embodiment 1, wherein oil exists to be selected from following concentration: 1.25%w/v, 0.01%-w/v – 10.0%w/v, 0.1%w/v – 5.0%w/v, 0.1%w/v – 4.0%w/v, 0.1%w/v – 3.0%w/v, 0.1%w/v – 2.0%w/v, 0.1%w/v – 1.0%w/v, 0.1%w/v – 0.9%w/v, 0.1%w/v – 0.8%w/v, 0.1%w/v – 0.8%w/v, 0.1%w/v – 0.7%w/v, 0.1%w/v – 0.6%w/v, 0.1%w/v – 0.5%w/v, 0.1%w/v – 0.4%w/v, 0.1%w/v – 0.3%w/v, 0.1%w/v – 0.2%w/v, 0.09%-0.1%w/v, 0.08%-0.1%w/v, 0.07%-0.1%w/v, 0.06%-0.1%w/v, 0.05%-0.1%w/v, 0.04%-0.1%w/v, 0.03%-0.1%w/v, 0.02%-0.1%w/v, 0.01%-0.1%w/v, 0.01 – 0.09%, 0.01 – 0.08%, 0.01 – 0.07%w/v, 0.01-0.06%w/v, 0.01 – 0.05%w/v, 0.01 – 0.04%w/v, 0.01 – 0.03%w/v, 0.01-0.02%w/v, 0.01 – 0.0125%w/v and 0.05%w/v – 5.0%w/v (most preferably 0.05%w/v – 5.0%).
Embodiment 15: a kind of method of promoting fingernail health in human or animal, promoting horny layer health and/or promoting nail growth, the method comprises:
Apply fingernail from O/w emulsion to human or animal, horny layer or nail matrix part every day at least one times, and wherein this emulsion comprises immunomodulator and/or antiinflammatory.
Embodiment 16: the method for embodiment 15, wherein O/w emulsion comprises Ciclosporin A.
Embodiment 17: the method for embodiment 15, wherein O/w emulsion comprises ketorolac.
Embodiment 18: the method for embodiment 15-18 any one, wherein oil is Oleum Ricini and O/w emulsion also comprises surfactant polysorbate80.
Embodiment 19: the method for embodiment 15-18 any one, wherein emulsion also comprises glycerol.
Embodiment 20: the method for embodiment 15, wherein grease separation is certainly: Oleum Anisi Stellati; Oleum Ricini; Oleum Caryophylli; Oleum Cinnamomi; Oleum Cinnamomi; The oil of proportion between 0.90 and 0.95; Almond oil; Semen Maydis oil; Oleum Arachidis hypogaeae semen; Oleum Gossypii semen; Safflower oil; Oleum maydis; Semen Lini oil; Oleum Brassicae campestris; Soybean oil; Olive oil; Caraway seed oil; Oil of rosemary; Oleum Arachidis hypogaeae semen; Oleum menthae; Oleum helianthi; Eucalyptus oil; Oleum sesami; The oil that proportion is less than 0.9; Mineral oil; Fructus Coriandri oil; Oleum lavandula angustifolia; Citronella oil; Oleum juniperi e baccarae; Fructus Citri Limoniae oil; Orange oil; Sage oil; Semen Myristicae oil; And tea tree oil.
Embodiment 21: the method for embodiment 15, wherein O/w emulsion also comprises and is selected from following surfactant: polysorbate80, carboxylation and ethoxylated alcohol, amine oxide, block polymer, the fatty acid that comprises carboxylic fatty acids, ethoxylated alkylphenol, ethoxylated fat ester, glyceride, lanoline radical derivative, lignin derivative, methyl ester, monoglyceride and triglyceride, Polyethylene Glycol, polymeric surfactant, propoxylation and ethoxylated fatty acid, alcohol, or alkyl phenol, protein-based surfactant, sucrose and glucose ester and derivant.
Embodiment 22: the method for embodiment 15-21 any one, wherein oil exists to be selected from following concentration: 0.01%-w/v – 10.0%w/v, 0.1%w/v – 5.0%w/v, 0.1%w/v – 4.0%w/v, 0.1%w/v – 3.0%w/v, 0.1%w/v – 2.0%w/v, 0.1%w/v – 1.0%w/v, 0.1%w/v – 0.9%w/v, 0.1%w/v – 0.8%w/v, 0.1%w/v – 0.8%w/v, 0.1%w/v – 0.7%w/v, 0.1%w/v – 0.6%w/v, 0.1%w/v – 0.5%w/v, 0.1%w/v – 0.4%w/v, 0.1%w/v – 0.3%w/v, 0.1%w/v – 0.2%w/v, 0.09%-0.1%w/v, 0.08%-0.1%w/v, 0.07%-0.1%w/v, 0.06%-0.1%w/v, 0.05%-0.1%w/v, 0.04%-0.1%w/v, 0.03%-0.1%w/v, 0.02%-0.1%w/v, 0.01%-0.1%w/v, 0.01 – 0.09%, 0.01 – 0.08%, 0.01 – 0.07%w/v, 0.01-0.06%w/v, 0.01 – 0.05%w/v, 0.01 – 0.04%w/v, 0.01 – 0.03%w/v, 0.01-0.02%w/v, 0.01 – 0.0125%w/v and 0.05%w/v – 5.0%w/v (most preferably 0.05%w/v – 5.0%w/v).
Embodiment 23: the method for embodiment 15-22 any one, wherein surfactant exists to be selected from following concentration: 1.0%w/v, 0.01%-w/v – 10.0%w/v, 0.1%w/v – 5.0%w/v, 0.1%w/v – 4.0%w/v, 0.1%w/v – 3.0%w/v, 0.1%w/v – 2.0%w/v, 0.1%w/v – 1.0%w/v, 0.1%w/v – 0.9%w/v, 0.1%w/v – 0.8%w/v, 0.1%w/v – 0.7%w/v, 0.1%w/v – 0.6%w/v, 0.1%w/v – 0.5%w/v, 0.1%w/v – 0.4%w/v, 0.1%w/v – 0.3%w/v, 0.1%w/v – 0.2%w/v, 0.09%-0.1%w/v, 0.08%-0.1%w/v, 0.07%-0.1%w/v, 0.06%-0.1%w/v, 0.05%-0.1%w/v, 0.04%-0.1%w/v, 0.03%-0.1%w/v, 0.02%-0.1%w/v, 0.01%-0.1%w/v, 0.01 – 0.09%, 0.01 – 0.08%, 0.01 – 0.07%w/v, 0.01-0.06%w/v, 0.01 – 0.05%w/v, 0.01 – 0.04%w/v, 0.01 – 0.03%w/v, 0.01-0.02%w/v and 0.01 – 0.0125%w/v.
Embodiment 24: the method for embodiment 15-23 any one, it also can be used for treatment and is selected from following toenail and fingernail obstacle: onychorrhexis syndrome, fingernail psoriasis, psoriasis onychodystrophy, onychorrhexis syndrome, first length and thickness increase, onychitis, curved first disease, onychoatrophy, ingrowing nail, Onychodystrophy, onychogryphosis, onycholysis, onychomadesis, onychauxis, tinea unguium, onychorrhexis, tinea unguium, onychophosis, onychoptosis, paronychia, pseudomonas infection, pterygium and pterygium inversum unguis, spoon nail, hematoma under nail or other wounds to fingernail, folic acid deficiency, leukonychia, refer to chatelain's syndrome, melanonychia, hypoproteinosis, onychorrhexis and first are peeled off, the first of methyl methacrylate damage, vitamin C deficiency, avitaminosis, first tinea alba, the first relevant to lichen planus is thin soft, Raynaud disease, relevant to rheumatoid arthritis bleeds, Beau lines, poisoning relevant Michaelis line to some type.
Embodiment 25: medicine or cosmetic composition are used for the treatment of the purposes aspect the medicament that is selected from following disease in manufacture: onychorrhexis syndrome, fingernail psoriasis, psoriasis onychodystrophy, onychitis, curved first, onychoatrophy, ingrowing nail, Onychodystrophy, onychogryphosis, onycholysis, onychomadesis, onychauxis, tinea unguium, onychorrhexis, tinea unguium, onychophosis, onychoptosis, paronychia, pseudomonas infection, pterygium and pterygium inversum unguis, spoon nail, hematoma under nail or other wounds to fingernail, folic acid deficiency, leukonychia, refer to chatelain's syndrome, melanonychia, hypoproteinosis, onychorrhexis and first are peeled off, the first of methyl methacrylate damage, vitamin C deficiency, avitaminosis, first tinea alba, the first relevant to lichen planus is thin soft, Raynaud disease, relevant to rheumatoid arthritis bleeds, Beau lines and Michaelis line, wherein said composition is O/w emulsion, and comprise immunomodulator and/or antiinflammatory.
Embodiment 26: the purposes of embodiment 25, wherein ciclosporin exists to be selected from following concentration: 0.1 to 20%w/v, 0.1 – 10%w/v, 0.1 – 5%w/v, 0.1 – 1.0%w/v, 0.09%-0.1%w/v, 0.08%-0.1%w/v, 0.07%-0.1%w/v, 0.06%-0.1%w/v, 0.05%-0.1%w/v, 0.04%-0.1%w/v, 0.03%-0.1%w/v, 0.02%-0.1%w/v, 0.01%-0.1%w/v, 0.01 – 0.09%, 0.01 – 0.08%, 0.01 – 0.07%w/v, 0.01-0.06%w/v, 0.01 – 0.05%w/v, 0.01 – 0.04%w/v, 0.01 – 0.03%w/v, 0.01-0.02%w/v, 0.01 – 0.0125%w/v, and most preferably 0.01 to 0.05% or 0.01%w/v, 0.0125%w/v, 0.02%w/v, 0.03%w/v, 0.04%w/v, 0.05%w/v, 0.06%w/v, 0.07%w/v, 0.08%w/v, 0.09%w/v, 0.1%w/v, 0.005%w/v and 0.0015%w/v.
The specific embodiment
Definition
As used herein, following definition is applicable:
" onychorrhexis syndrome " means easily crisp, frangible, hangnail of fingernail, peels off, cracking, crude, dull, attenuation, layering, coarse and/or wearing and tearing.
" horny layer " or " eponychium " means the skin layer that thickens around fingernail.
" enhancement nail growth " means to increase Growth rate of fingernail and/or fingernail thickness.
" promote fingernail healthy " or " improving fingernail health " means to reduce fingernail depression, fingernail cracking, fingernail division, fingernail dimness, fingernail coarse (asperities first), fingernail is crude, fingernail peels off, usure des ongles, be easy to tear, fingernail layering (stratiform onycholysis), Beau lines, onychomadesis, oncholysis, onychorrhexis, fingernail is frangible, valleculae unguis is scorching, tinea unguium and/or onychorrhexis syndrome." promote fingernail healthy " and comprise treatment onychorrhexis syndrome.
" excipient " for example means, with medicine (" immunomodulator " and/or " antiinflammatory ") combination to produce any material of pharmaceutical dosage form.This type of excipient capable of being combined is for example to promote drug delivery.The limiting examples of excipient comprises for example water, oil, surfactant and coloring agent.
" fingernail " means toenail and/or fingernail.Fingernail comprises nail plate, nail matrix, the nail matrix under it and around its valleculae unguis.Fingernail consists of keratin.
" safe and effective amount " refers to the following amount of compositions, and this amount is enough to provide the treatment to a certain degree to disease, but this amount does not make greatly treatment be medically unadvisable degree to user is had side effects.
" treatment effectively " or " treatment " mean when being applied to fingernail according to reliable medical science experience under the background of preparation, and it produces promotes the provable effect that fingernail is healthy, promote horny layer health and/or promote nail growth.This proof can in macropathology aspect (for example, by vulnerability for example, peel off, the minimizing of cracking, crude, coarse and/or hangnail and visually improve fingernail health; And/or the measured increase of nail growth) or in subjective aspect (experimenter's perception fingernail healthy, horny layer is healthy and/or the enhancement of nail growth).Treatment effectively or treatment can be healing property, palliative and/or control property or prophylactic treatment.
Unless otherwise prescribed, otherwise about " % " of the concentration of component of compositions, mean the ratio representing with percentage ratio of composition weight and gross weight.
Can be used for putting into practice compositions of the present invention can be emulsion, colloid, suspension, semisolid, solution, dispersion liquid, capsule, gel, lotion, ointment etc.Compositions of the present invention comprises at least one in immunomodulator (as ciclosporin), antiinflammatory (as ketorolac), retinoid (as tazarotene), biotin and silicone.In certain embodiments, ciclosporin component can combine with the carrier that forms emulsion after mixing with water.This type of emulsion is for example not limited to describe to some extent in the United States Patent (USP) 4,388,307 of Cavanak, and the disclosure of this patent is incorporated to introducing mode integral body accordingly.
Compositions of the present invention is applied on fingernail by applicator part, and can use one or many every day in certain embodiments.According to the present invention, emulsion formulations plays promotes the effect that fingernail is healthy, promote horny layer health and/or enhancement nail growth.For example, in certain embodiments, emulsion formulations plays and fingernail and horny layer is improved and/or return to its natural health situation (for example make fingernail thicken, strengthen and smoothly) and aspect thickness and length, improving the effect of nail growth.Compositions of the present invention can be used for treating toenail and fingernail obstacle, such as onychorrhexis syndrome, fingernail psoriasis, psoriasis onychodystrophy, onychorrhexis syndrome, first length and thickness increase, onychitis, curved first disease, onychoatrophy, ingrowing nail, Onychodystrophy, onychogryphosis, onycholysis, onychomadesis, onychauxis, tinea unguium, onychorrhexis, tinea unguium, onychophosis, onychoptosis, paronychia, pseudomonas infection, pterygium and pterygium inversum unguis, spoon nail, hematoma under nail or other wounds to fingernail, folic acid deficiency, leukonychia, refer to chatelain's syndrome, melanonychia, hypoproteinosis, onychorrhexis and first are peeled off, the first of methyl methacrylate damage, vitamin C deficiency, avitaminosis, first tinea alba, the first relevant to lichen planus is thin soft, Raynaud disease, relevant to rheumatoid arthritis bleeds, Beau lines, poisoning relevant Michaelis line to some type.
In addition, it is healthy that these compositionss will be promoted overall fingernail, increase fingernail intensity, increase Fingernail growth rate and thickness, promote horny layer healthy, reduce onychorrhexis syndrome, a little less than reducing first, reduce fingernail depression, reduce fingernail cracking, reduce fingernail division, reduce fingernail dull, reduce fingernail coarse (asperities first), reduce fingernail crude, reducing fingernail peels off, reduce usure des ongles, reduce fingernail and be easy to lancinating, reduce fingernail layering (stratiform onycholysis), reduce Beau lines, reduce onychomadesis, reduce oncholysis, reduce onychorrhexis, reduce fingernail fragility, reduce paronychia and reduce tinea unguium.
In alternate embodiment of the present invention, such as when comprising water-in-oil emulsion, described emulsion comprises hydrophobic components, such as pharmaceutically acceptable oil.Hydrophobic components can exist by effective dose, for example with the amount of the highest about 0.01%-90%w/v, exists, but preferred about 0.01-10%w/v, 0.05%-5%w/v, 0.05%-2%w/v or 1.0%-1.5%w/v.The example of available pharmaceutically acceptable oil comprises vegetable oil, animal oil, mineral oil, synthetic wet goods and composition thereof.In alternate embodiment, hydrophobic components can comprise a kind of or compared with higher fatty acids glyceride or consisting of.In certain embodiments, hydrophobic components comprises Oleum Ricini.
Surfactant also can exist by the amount of the highest about 0.01-10%w/v, 0.05%-5%w/v, 0.05%-2%w/v or 1.0%-1.5%w/v.Surfactant can comprise: alcohol (comprising carboxylation and ethoxylated alcohol), amine oxide, block polymer, fatty acid (comprising carboxylic fatty acids), ethoxylated alkylphenol, ethoxylated fat ester, glyceride, lanoline radical derivative, lignin derivative, methyl ester, monoglyceride and triglyceride, Polyethylene Glycol, polymeric surfactant, propoxylation and ethoxylated fatty acid, alcohol or alkyl phenol, protein-based surfactant, sucrose and glucose ester and derivant.In certain embodiments, surfactant is polysorbate, polysorbate80 particularly, but also can use other surfactants.
Any known pharmaceutically acceptable surfactant be can use, nonionic surfactant, anionic surfactant, cationic surface active agent and combination thereof comprised.Can use nonionic surfactant, especially hydrophilic/lipophilic balance value (HLB) is 10 or those higher surfactants.Or, can utilize some combination of the surfactant of high HLB and low HLB; Comprise such mixed surfactant, its usage rate makes the surfactant HLB (according to usage ratio weighting) adding up to still surpass 10.
The example of suitable surfactant includes but not limited to: natural or hydrogenated vegetable oil is as the polyoxyethylene deriv of Oleum Ricini; Polyoxyethylene-sorbitan aliphatic ester, as single lauryl, two lauryl, three lauryls, palmityl ester, stearoyl ester and oleoyl ester; Alkyl/dialkyl sulfate, sulfonate or sulfosuccinate, as sodium lauryl sulphate and dioctyl sodium sulphosuccinate; Polyoxyethylene fatty acid ester; Phospholipid, as lecithin; The ester exchange offspring of crude vegetal triglyceride and polyalkylene polyhydric alcohol; Sorbitan aliphatic ester; Pentaerythritol fatty ester; Polyoxyethylene glycol alkyl ether (polyoxyethylene glycol alkyl ether) and ester; Etc..These surfactants can be used alone or in combination.
The example of available concrete surfactant includes but not limited to: castor oil derivatives, oxyl 35 Oleum Ricini (polyoxyethylene glycerol triricinoleate polyoxyl35castor oil) as poly-in polyoxyethylene trimerization ricinoleic acid glyceride ( eL, can derive from BASF Corporation) and poly-oxyl 40 castor oil hydrogenated ( rH40, can derive from BASF Corporation); The mono fatty acid ester of polyoxyethylene (20) sorbitan, as polyoxyethylene (20) sorbitan monoleate ( ), polyoxyethylene (20) sorbitan monostearate ( 60), polyoxyethylene (20) sorbitan monopalmitate ( 40) and polyoxyethylene (20) sorbitan monolaurate ( 20) (all can derive from ICI Surfactants, Wilmington, Del.); Polyoxyethylene glycol 200 monostearates ( 52, can derive from Calgene Chemicals, Skokie, Ill.); HLB is 10 or higher polyglycerin ester, as single oleic acid ten polyglycerin ester and two oleic acid ten polyglycerin ester etc.; And composition thereof.
(when compositions is prepared into semisolid), maybe advantageously, is used at least one other low HLB surfactant together with one or more above-mentioned high HLB surfactants in some cases.The example of available low HLB cosurfactant include but not limited to polyglycerol acrylate (as 10G40); Lecithin; Glyceryl monooleate or Masine 35-1 mixture (as 18-99 or 18-92); Propylene glycol laurate; With sorbitan oleate, as sorbitan monoleate ( 80), Span 85 ( 85) and sorbitan sesquioleate ( 20) (all can derive from ICI Surfactants, Wilmington, Del.).Surfactant can account for approximately 10 % by weight to 90 % by weight of compositions mutually.In certain embodiments, surfactant accounts for approximately 20 % by weight of compositions to approximately 70 % by weight, and in other embodiments, approximately 40 % by weight are to approximately 60 % by weight.
(I) immunomodulator
Immunomodulator also referred to as immunotherapeutic agent is for example, to the influential material of immune system tool (, medicine).Immunomodulator can be used in compositions of the present invention, and comprises immunosuppressant, immunostimulant and toleragen.Immunosuppressant for example in autoimmune disease Immunosuppression reply.Immunostimulant strengthens immunne response, and can be used for for example infecting, immunodeficiency and cancer.Toleragen inducing tolerance also makes tissue reactionless to antigen.
Can be used for immunomodulator in compositions of the present invention comprises and being not limited to: ciclosporin, tacrolimus, azathioprine, cyclophosphamide, methotrexate, chlorambucil, mycophenolate mofetil, prednisolone, Muromonab-CD3, antithymocyte globulin (ATG), Rho (D) immunoglobulin, efalizumab, levamisole, Sa Li polyamines and composition thereof.In at least one embodiment, for the immunomodulator of compositions, be ciclosporin.
ciclosporin
As previously mentioned, compositions of the present invention can comprise ciclosporin or other reactive compounds.Ciclosporin is the nonpolar cyclic oligopeptides that a class has known immunosuppressive activity.Identified Ciclosporin A and several other minor metabolites, and ciclosporin B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y and Ζ.In addition, the derivant of this type of ciclosporin, salt etc. and some synthetic analogues have also been produced and have can be used for the present invention.Ciclosporin A and Ciclosporin A derivant have been the themes of multinomial patent in the purposes aspect treatment eye disease, such as the people's such as Ding United States Patent (USP) 5,474,979; The United States Patent (USP) 6,254,860,6,350,442 and 7,368,436 of Garst; Their disclosure is all incorporated to herein with introducing mode integral body.
In general, commercially available ciclosporin can comprise the mixture of several independent ciclosporins, it is approximately 1200 cyclic peptide structures that these ciclosporins all have the total molecular weight consisting of 11 amino acid residues, but wherein some amino acid whose substituent group or configuration different.
Term " ciclosporin component " is intended to comprise any separate member, its salt, its derivant, its analog of cyclosprins and composition thereof as used herein, and mixture of two or more independent ciclosporins, its salt, its derivant, its analog and composition thereof.
In certain embodiments, ciclosporin component includes but not limited to the derivant of Ciclosporin A, Ciclosporin A, salt of Ciclosporin A etc. and composition thereof.Ciclosporin A is available ciclosporin component.
The chemical constitution of Ciclosporin A is represented by formula 1:
As used herein, " derivant " of term ciclosporin refers to such compound, thus its have to ciclosporin enough similarly structure in the method for the invention to work to the substantially similar or essentially identical mode of ciclosporin (as Ciclosporin A).Available Ciclosporin A derivant includes but not limited to be selected from ((R)-methyl mercapto-Sar) hereinafter described 3-(4'-hydroxyl-MeLeu) Ciclosporin A, ((R)-(ring) alkylthio group-Sar) 3-(4'-hydroxyl-MeLeu) 4-Ciclosporin A and ((R)-(ring) alkylthio group-Sar) 3those of-Ciclosporin A derivant.
These ciclosporin derivants are respectively by following general formula (II), (III) and (IV) expression:
Wherein Me is methyl; Alk is 2-6C alkylidene or 3-6C cycloalkylidene; R is OH, COOH, alkoxy carbonyl group ,-NR 1r 2or N (R 3)-(CH 2)-NR 1r 2; R wherein 1, R 2by H, alkyl, 3-6C cycloalkyl, phenyl (optionally being replaced by halogen, alkoxyl, alkoxy carbonyl group, amino, alkylamino or dialkyl amido), benzyl or the saturated or undersaturated 1-3 of having heteroatomic 5 or 6 yuan of heterocyclic radicals; Or NR 1r 2also can be by alkylating 5 or 6 yuan of heterocycles for comprising other N, O or S hetero atom; R 3for H or alkyl and n are 2-4; And moieties comprises 1-4C.
(II) anti-inflammatory agent
Antiinflammatory or anti-inflammatory agent are the acceptable medicaments with anti-inflammatory activity in one or more dermatological, it comprise weaken inflammatory reaction and no matter potential mechanism (prostaglandin is synthetic such as suppressing, leukotriene generation, macrophage function etc.) medicament how.The anti-inflammatory agent can be used in the present invention comprises the micromolecule (for example NSAID (non-steroidal anti-inflammatory drug) or NSAID) that is not limited to structure and has illustrated, and comprise its polymorph, crystal habit, its prodrug and isomer (comprising optical isomer, geometric isomer and tautomer), its enantiomer, salt, solvate and complex with and solvate and the complex of salt.
The anti-inflammatory agent can be used in compositions of the present invention comprises NSAID (non-steroidal anti-inflammatory drug) (NSAID), steroid (for example corticosteroid) and biology or plant extract or preparation.
The instantiation that can be used for the NSAID in compositions of the present invention includes but not limited to: aspirin, alclofenac, alminoprofen, benoxaprofen, butibufen, bucloxic acid, bufexamac, carprofen, celecoxib, clidenac, diclofenac, Diflonid, entiazac, etodolac, etofenamate, felbinac, fenbufen, fenoprofen, fentiazic, fepradinol, flufenamic acid, flufenasol, flurbiprofen, furofenac, ibufenac, ibuprofen, indometacin, indoprofen, Isoxepac, isoxicam, ketoprofen, ketorolac, meclofenamic acid, mefenamic acid, meloxicam, miroprofen, naproxen, niflumic acid, Oxaprozin, crovaril, oxpinac, parecoxib, Phenylbutazone, Piclamilast, piketoprofen, piroxicam, pirprofen, pranoprofen, rofecoxib, sonixin (sonixin), sudoxicam, sulindac, suprofen, suxibuzone, tenclofenac, tiaprofenic acid, tolfenamic acid, tolmetin, tramadol, Valdecoxib, zomepirac, its pharmacological activity base addition salts, and composition thereof.In at least one embodiment, for the NSAID of compositions, be ketorolac.
ketorolac
Ketorolac is the NSAID in heterocycle acetogenin family.Thereby ketorolac is blocked synthetic playing a role in the body that cyclo-oxygenase suppresses prostaglandin by competitiveness.Ketorolac is the isostere of ketoprofen.More precisely, it is piperazine (dihydropyrrolizine) carboxylic acid derivates in structurally relevant to indomethacin pyrrolin.Prepared derivant, salt of ketorolac etc., they can be used for the present invention.In at least one embodiment, the tromethane salt of ketorolac is used for to compositions of the present invention.The system of ketorolac (IUPAC) name is called: (±)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid 2-amino-2-(methylol)-1,3-PD salt.
The chemical constitution of ketorolac is as follows:
(III) oil
Can be used for compositions of the present invention (particularly emulsion) and can be used for comprising two or more oil including but not limited to together with the oil of the conjugate of surfactant, two or more surfactants:
Oleum Anisi Stellati, Oleum Ricini, Oleum Caryophylli, Oleum Cinnamomi, Oleum Cinnamomi, the oil of proportion between 0.90 and 0.95, almond oil, Semen Maydis oil, Oleum Arachidis hypogaeae semen, Oleum Gossypii semen, safflower oil, oleum maydis, Semen Lini oil, Oleum Brassicae campestris, soybean oil, olive oil, caraway seed oil, oil of rosemary, Oleum Arachidis hypogaeae semen, Oleum menthae, Oleum helianthi, Eucalyptus oil, Oleum sesami, proportion is lower than 0.9 oil, mineral oil, Fructus Coriandri oil, Essential lavender oil, citronella oil, oleum juniperi e baccarae, Fructus Citri Limoniae oil, orange oil, sage oil, Semen Myristicae oil and tea tree oil.
(IV) surfactant
Can and include but not limited to for surfactant of the present invention together with one or more surfactants together with one or more oil:
alcohol, include but not limited to:
it can derive from Solvay Chemicals, Inc.; Hetoxide it can derive from Global-Seven, Inc.; Lexemul it can derive from Inolex Chemical Co.; it can derive from Solvay Chemicals, Inc.; Redicote E it can derive from Akzo Nobel Surface Chemistry LLC; Simulsol OX it can derive from Seppic Inc.; Stanfax it can derive from Para-Chem Standard Div.; it can derive from Procter & Gamble; And Witconol it can derive from Akzo Nobel Surface Chemistry LLC.
amine oxide, include but not limited to:
It can derive from Tomah Inc.; It can derive from Tomah Inc.; AO728 It can derive from Tomah Inc.;Barlox It can derive from Lonza Inc.; Barlox It can derive from Lonza Inc.; Burcoxide It can derive from Burlington Chemical Inc.; Caloxamine It can derive from Pilot Chemical Co.;Chemoxide It can derive from Chemron Corp.; Chemoxide It can derive from Chemron Corp.; Chemoxide It can derive from Chemron Corp.; Chemoxide It can derive from Chemron Corp.; Colalux It can derive from Colonial Chemical Co.;Colalux It can derive from Colonial Chemical Co.; DeMox It can derive from DeForest Enterprises, Inc.; DeMox It can derive from DeForest Enterprises, Inc.; DeMox It can derive from DeForest Enterprises, Inc.; It can derive from Crompton Corp.;Empigen It can derive from Huntsman LLC; Empigen It can derive from Huntsman LLC; Foamox It can derive from Alzo International, Inc.; Foamox It can derive from Alzo International, Inc.; Foamox It can derive from Alzo International, Inc.;Genaminox It can derive from Clariant Corporation; Genaminox It can derive from Clariant Corporation; Hartofoam It can derive from Hart Chemical Corp.; Hartox It can derive from Hart Chemical Corp.; Lipowax It can derive from Lipo Chemicals, Inc.;Lipowax PB It can derive from Lipo Chemicals, Inc.; Mackamine It can derive from The McIntyre Group; Mackamine It can derive from The McIntyre Group; Mackamine It can derive from The McIntyre Group; Mackamine It can derive from The McIntyre Group;Mackamine It can derive from The McIntyre Group; Mackamine It can derive from The McIntyre Group; Mackamine It can derive from The McIntyre Group; Mackamine It can derive from The McIntyre Group; Mackamine It can derive from The McIntyre Group;Mazox It can derive from BASF Corp.; Monalac It can derive from Uniqema; Norfox It can derive from Norman, Fox & Co.; Rhodamox It can derive from Rhodia, Inc.; Schercamox It can derive from Inc.;Schercamox It can derive from Inc.; Schercamox It can derive from Inc.; Schercamox It can derive from Inc.;Schercamox It can derive from Inc.; Tegotens It can derive from Goldschmidt Chemical Corp.; Tomah It can derive from Tomah Inc.; Triaminox It can derive from Tri-Tex Inc.; Mazox CDA And Standamox
block polymer, include but not limited to:
AL It can derive from Uniqema; Antarox It can derive from Rhodia, Inc.; Antarox It can derive from Rhodia, Inc.; Antarox It can derive from Rhodia, Inc.; Antarox It can derive from Rhodia, Inc.; Antarox It can derive from Rhodia, Inc.; Arnox It can derive from Crompton Corp.; Chemonic It can derive from Chemron Corp.; Chemonic It can derive from Chemron Corp.; Chemonic PL It can derive from Chemron Corp.; Ethox It can derive from Ethox Chemicals, LLC;Ethox It can derive from Ethox Chemicals, LLC; Genapol It can derive from Clariant Corporation; Genapol It can derive from Clariant Corporation; Genapol It can derive from Clariant Corporation; Norfox It can derive from Norman, Fox & Co.; Pluronic, it can derive from BASF;Simulsol NW It can derive from Seppic Inc.; It can derive from Harcros Chemicals Inc.; T-Det It can derive from Harcros Chemicals Inc.; T-Det It can derive from Harcros Chemicals Inc.; Triton It can derive from Dow Chemical Company;Witconol It can derive from Akzo Nobel Surface Chemistry LLC; Witconol It can derive from Akzo Nobel Surface Chemistry LLC; Witconol It can derive from Akzo Nobel Surface Chemistry LLC; Witconol It can derive from Akzo Nobel Surface Chemistry LLC; Chemal BP Chemal BP Chemal BP Chemal BP Pluronic Pluronic Pluronic Pluronic Pluronic Pluronic Pluronic Pluronic Pluronic Pluronic Pluronic Pluronic Pluronic Pluronic Pluronic Pluronic Pluronic Pluronic Pluronic Pluronic Pluronic Pluronic Pluronic Pluronic Pluronic Pluronic Pluronic Pluronic Pluronic Pluronic Pluronic Pluronic Pluronic Pluronic Pluronic Pluronic Surfonic Surfonic Tetronic Tetronic Tetronic Tetronic Tetronic Tetronic Tetronic Tetronic And Tetronic
carboxylation alcoholor alkylphenol ethoxylate, include but not limited to:
Emcol it can derive from Crompton Corp.; it can derive from Ethox Chemicals, LLC; Gemtex it can derive from Finetex Inc.; Incrodet it can derive from Croda Inc.; Marlinat CM it can derive from Sasol North America Inc.; Marlowet it can derive from Sasol North America Inc.; Marlowet it can derive from Sasol North America Inc.; Marlowet4530 it can derive from Sasol North America Inc.; Marlowet it can derive from Sasol North America Inc.; Marlowet it can derive from Sasol North America Inc.; Marlowet it can derive from Sasol North America Inc.; Marlowet4539 it can derive from Sasol North America Inc.; Marlowet it can derive from Sasol North America Inc.; Miranate it can derive from Rhodia, Inc.; Sandopan it can derive from Clariant Corporation; Sandopan B it can derive from Clariant Corporation; Sandopan LS-24 it can derive from Clariant Corporation; Surfine it can derive from Finetex Inc.; And Surfine AZI-A.
carboxylic acid/fatty acid, include but not limited to:
Colaterge it can derive from Colonial Chemical Co.; Colatrope it can derive from Colonial Chemical Co.; Crodacid it can derive from Croda Inc.; DeTrope it can derive from DeForest Enterprises, Inc.; Latol it can derive from Georgia-Pacific Corp.; Lumulse CC-33 it can derive from Lambent Technologies Corp.; Mulls it can derive from Bernel Chemical inc.; it can derive from Procter & Gamble; it can derive from Procter & Gamble; it can derive from Procter & Gamble; it can derive from Procter & Gamble; Sandopan DTC it can derive from Clariant Corporation; Sandopan LS24 it can derive from Clariant Corporation; And Sandopan it can derive from Clariant Corporation.
ethoxylated alcohol, include but not limited to:
Adsee It can derive from Akzo Nobel Surface Chemistry LLC; Adsee It can derive from Crompton Corp.; Alfonic It can derive from Sasol North America Inc.; Alfonic It can derive from Sasol North America Inc.; Alfonic It can derive from Sasol North America Inc.;Alfonic It can derive from Sasol North America Inc.; Alfonic It can derive from Sasol North America Inc.; Alfonic It can derive from Sasol North America Inc.; Alfonic It can derive from Sasol North America Inc.; Alfonic It can derive from Sasol North America Inc.;Alfonic It can derive from Sasol North America Inc.; Arlasolve It can derive from Uniqema; Arlasolve200 It can derive from Uniqema; Armix It can derive from Crompton Corp.; Armix It can derive from Crompton Corp.;Armul It can derive from Akzo Nobel Surface Chemistry LLC; Armul It can derive from Crompton Corp.; Atlas It can derive from Atlas Refinery Inc.; Atlas It can derive from Uniqema; Atlas It can derive from Uniqema;Atlas It can derive from Uniqema; Bio Soft It can derive from Stepan Canada Inc.; Bio Soft It can derive from Stepan Canada Inc.; Bio Soft It can derive from Stepan Canada Inc.; Bio Soft EN It can derive from Stepan Canada Inc.;Bio Soft It can derive from Stepan Canada Inc.; Bio Soft It can derive from Stepan Canada Inc.; Brij It can derive from Uniqema; Brij It can derive from Uniqema; Brij It can derive from Uniqema; Brij It can derive from Uniqema; Brij It can derive from Uniqema; Brij It can derive from Uniqema; Brij It can derive from Uniqema; Brij It can derive from Uniqema; Brij It can derive from Uniqema; Brij It can derive from Uniqema;Brij It can derive from Uniqema; Brij700 It can derive from Uniqema; Brij It can derive from Uniqema; Brij721 It can derive from Uniqema; Burcoterge It can derive from Burlington Chemical Inc.;Canasol AT It can derive from Canamex Quimicos S.A de C.v; Canasol AT It can derive from Canamex Quimicos S.A de C.v; Canasol AT It can derive from Canamex Quimicos S.A de C.v; Canasol BJ It can derive from Canamex Quimicos S.A de C.v; Canasol BJ It can derive from Canamex Quimicos S.A de C.v;Canasol BJ It can derive from Canamex Quimicos S.A de C.v; Canasol BJ It can derive from Canamex Quimicos S.A de C.v; Canasol BJ It can derive from Canamex Quimicos S.A de C.v; Canasol BJ It can derive from Canamex Quimicos S.A de C.v; Canasol BJ It can derive from Canamex Quimicos S.A de C.v;Canasol BJ It can derive from Canamex Quimicos S.A de C.v; Cerfak It can derive from Houghton International Inc.; Cetomacrogol1000 It can derive from Croda Inc.; Chemonic It can derive from Chemron Corp.; Chemonic It can derive from Chemron Corp.;Chemonic It can derive from Chemron Corp.; Chemonic It can derive from Chemron Corp.; Chemonic It can derive from Chemron Corp.; Chemonic It can derive from Chemron Corp.; Chemonic It can derive from Chemron Corp.;Chemonic It can derive from Chemron Corp.; Chemonic It can derive from Chemron Corp.; Chemonic It can derive from Chemron Corp.; Chemonic It can derive from Chemron Corp.; Chemonic It can derive from Chemron Corp.;Chemonic It can derive from Chemron Corp.; Chemonic It can derive from Chemron Corp.; Chemonic It can derive from Chemron Corp.; Chemonic It can derive from Chemron Corp.; Chemonic It can derive from Chemron Corp.;Chemonic It can derive from Chemron Corp.; Chemonic It can derive from Chemron Corp.; Chemonic It can derive from Chemron Corp.; Colamulse It can derive from Colonial Chemical Co.; Cremophor It can derive from BASF Corp.;Cremophor SA It can derive from BASF Corp.; Dehydol It can derive from Cognis Canada Corp.; Dehydol It can derive from Cognis Canada Corp.; DeIonic It can derive from DeForest Enterprises, Inc.; DeSonic It can derive from Crompton Corp.;DeSonic It can derive from Crompton Corp.; DeSonic It can derive from Crompton Corp.; DeSonic It can derive from Crompton Corp.; DeSonic It can derive from Crompton Corp.; DeSonic It can derive from Crompton Corp.;DeSonic It can derive from Crompton Corp.; DeThox It can derive from DeForest Enterprises, Inc.; DeThox It can derive from DeForest Enterprises, Inc.; DeThox It can derive from DeForest Enterprises, Inc.; DeThox It can derive from DeForest Enterprises, Inc.;DeThox It can derive from DeForest Enterprises, Inc.; Disponil It can derive from Cognis Corporation; Eccoterge It can derive from Eastern Color & Chemical Co.; Empilan It can derive from Huntsman LLC; Empilan It can derive from Huntsman LLC;Empilan It can derive from Huntsman LLC; Empilan It can derive from Huntsman LLC; Empilan It can derive from Huntsman LLC; Ethylan It can derive from Akzo Nobel Surface Chemistry LLC; Ethylan It can derive from Akzo Nobel Surface Chemistry LLC;Ethylan It can derive from Akzo Nobel Surface Chemistry LLC; Ethylan It can derive from Akzo Nobel Surface Chemistry LLC; Ethylan It can derive from Akzo Nobel Surface Chemistry LLC; Ethylan It can derive from Akzo Nobel Surface Chemistry LLC; Ethylan It can derive from Akzo Nobel Surface Chemistry LLC;Ethylan It can derive from Akzo Nobel Surface Chemistry LLC; Eumulgin It can derive from Cognis Canada Corp.; Eumulgin It can derive from Cognis Canada Corp.; Eumulgin It can derive from Cognis Canada Corp.; Eumulgin It can derive from Cognis Canada Corp.;Flo Mo It can derive from Crompton Corp.; Flo Mo Low It can derive from Crompton Corp.; Forlan It can derive from RITA Corp.; Genapol It can derive from Clariant Corporation; Genapol It can derive from Clariant Corporation;Genapol It can derive from Clariant Corporation; Genapol It can derive from Clariant Corporation; Genapol DA It can derive from Clariant Corporation; Genapol HS It can derive from Clariant Corporation; Genapol HS It can derive from Clariant Corporation;Genapol It can derive from Clariant Corporation; Genapol It can derive from Clariant Corporation; Genapol It can derive from Clariant Corporation; Genapol LA It can derive from Clariant Corporation; Genapol LA It can derive from Clariant Corporation;Genapol LA It can derive from Clariant Corporation; Genapol LA It can derive from Clariant Corporation; Genapol LA It can derive from Clariant Corporation; Genapol LA It can derive from Clariant Corporation; Genapol LA It can derive from Clariant Corporation;Genapol LA It can derive from Clariant Corporation; Genapol LA It can derive from Clariant Corporation; Genapol O It can derive from Clariant Corporation; Genapol O It can derive from Clariant Corporation; Genapol O It can derive from Clariant Corporation;Genapol O It can derive from Clariant Corporation; Genapol SA It can derive from Clariant Corporation; Genapol SA It can derive from Clariant Corporation; Genapol It can derive from Clariant Corporation; Genapol It can derive from Clariant Corporation;Genapol It can derive from Clariant Corporation; Genapol It can derive from Clariant Corporation; Genapol It can derive from Clariant Corporation; Genapol It can derive from Clariant Corporation; Genapol It can derive from Clariant Corporation;Genapol X It can derive from Clariant Corporation; Genapol X It can derive from Clariant Corporation; Genapol X It can derive from Clariant Corporation; Genapol X It can derive from Clariant Corporation; Genapol X It can derive from Clariant Corporation;Genapol X It can derive from Clariant Corporation; Genapol It can derive from Clariant Corporation; Generol122 It can derive from Cognis Canada Corp.; Generol122 It can derive from Cognis Canada Corp.; Hostacerin It can derive from Clariant Corporation;Iconol LF It can derive from BASF Corp.; Incropol It can derive from Croda Inc.; Lexemul It can derive from Inolex Chemical Co.; Liponic It can derive from Lipo Chemicals, Inc.; Lipowax It can derive from Lipo Chemicals, Inc.;Lipowax It can derive from Lipo Chemicals, Inc.; Lipowax It can derive from Lipo Chemicals, Inc.; Lipowax It can derive from Lipo Chemicals, Inc.; Lipowax It can derive from Lipo Chemicals, Inc.; Lipowax It can derive from Lipo Chemicals, Inc.;Lumulse It can derive from Lambent Technologies Corp.; Macol It can derive from BASF Corp.; Marlox B It can derive from Sasol North America Inc.; Mazawet It can derive from BASF Corp.; Norfox It can derive from Norman, Fox & Co.;Norfox It can derive from Norman, Fox & Co.; Norfox Lo It can derive from Norman, Fox & Co.; Promulgen It can derive from Amerchol Corp.; Promulgen It can derive from Amerchol Corp.; Renex It can derive from Uniqema;Renex It can derive from Uniqema; Rhodasurf A It can derive from Rhodia, Inc.; Rhodasurf It can derive from Rhodia, Inc.; Rhodasurf It can derive from Rhodia, Inc.; Rhodasurf It can derive from Rhodia, Inc.;Rhodasurf DA It can derive from Rhodia, Inc.; Rhodasurf DA It can derive from Rhodia, Inc.; Rhodasurf DA It can derive from Rhodia, Inc.; Rhodasurf It can derive from Rhodia, Inc.; Rhodasurf It can derive from Rhodia, Inc.;Rhodasurf It can derive from Rhodia, Inc.; Rhodasurf TB-970 It can derive from Rhodia, Inc.; It can derive from RITA Corp.; Ritachol It can derive from RITA Corp.; Ritachol It can derive from RITA Corp.;Ritachol It can derive from RITA Corp.; Ritox It can derive from RITA Corp.; Surfonic It can derive from Huntsman LLC; Surfonic It can derive from Huntsman LLC; Surfonic It can derive from Huntsman LLC;Surfonic It can derive from Huntsman LLC; Synthrapol It can derive from Uniqema; It can derive from Goldschmidt Chemical Corp.; Teginacid It can derive from Goldschmidt Chemical Corp.; Tegotens EC It can derive from Goldschmidt Chemical Corp.;Tinegal It can derive from Ciba Specialty Chemicals Corp.; Tomadol It can derive from Tomah Inc.; Tomadol It can derive from Tomah Inc.; Tomadol It can derive from Tomah Inc.; Uniperol It can derive from BASF Corp.; Witconol SN It can derive from Crompton Corp.; T-Det T-Det T-Det T-Det T-Det T-Det T-Det T-Det T-Det T-Det T-Det T-Det T-Det T-Det T-Det T-Det T-Det T-Det T-Det T-Det Abex Abex Abex Abex Alfonic Alfonic Alfonic Alfonic Alfonic Alfonic Alfonic Alfonic Alfonic Ameroxol Ameroxol Ameroxol Armix Armix Armix Brij Brij35 Brij35 Canasol MJ Canasol MJ Canasol R Canasol R Canasol R4000 Chemal Chemal Chemal Chemal Chemal Chemal Chemal Chemal Chemal Chemal Chemal Chemal Chemal Chemal DeSonic Ethal Ethal Ethal Ethosperse Ethosperse Ethosperse Ethosperse Ethylan Ethylan Ethylan Generol122 Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol OA-10 Hetoxol OA-20 Hetoxol OA-3 Hetoxol OA-5 Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Hetoxol Iconol Iconol Iconol Iconol Iconol Iconol Iconol Iconol Iconol Iconol Lexemul Lipocol Lipocol Lipocol Lipocol Lipocol Lipocol Lipocol Lipocol Lipocol Lipocol Lipocol Lipocol Lipocol Lipocol Lipocol Lipocol Lipocol Marlox B Myrj Myrj Myrj Myrj Myrj Plurafac Plurafac Plurafac Plurafac Plurafac LF Plurafac LF Plurafac LF Plurafac Plurafac Plurafac Rhodasurf Rhodasurf Rhodasurf Rhodasurf Rhodasurf Rhodasurf L Rhodasurf L Rhodasurf L Rhodasurf L Rhodasurf L Rhodasurf L Rhodasurf L Rhodasurf L Rhodasurf L Rhodasurf Rhodasurf Rhodasurf Rhodasurf Rhodasurf Rhodasurf Ritapro Ritapro Ritapro Ritapro Ritoleth Ritoleth Ritoleth Ritoleth Solulan Solulan Solulan Solulan Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic T-Det T-Det T-Det T-Det T-Det T-Det T-Det T-Det T-Det T-Det T-Det T-Det T-Det T-Det T-Det T-Det T-Det T-Det T-Det T-Det T-Det T-Det T-Det Tergitol Tergitol Tergitol Tergitol15-S-20 Tergitol Tergitol Tergitol Tergitol15-S-40 Tergitol Tergitol Tergitol Tergitol Tergitol Tergitol Tergitol Tergitol Tergitol Tergitol Tergitol Tergitol Tergitol Tergitol Tergitol NP-30 Tergitol Tergitol TergitolNP-40 Tergitol NP-50 Tergitol NP-55 Tergitol Tergitol Tergitol NP-70 Tergitol Tergitol Tergitol Tergitol Tergitol Tergitol Tergitol Tergitol Tergitol Tomadol Tomadol Tomadol Tomadol Tomadol Tomadol Tomadol Tomadol Tomadol Tomadol Tomadol Tomadol Tomadol Tomadol Tomadol Tomadol Tomadol Volpo Volpo Volpo And
ethoxylated alkylphenol, include but not limited to:
Antarox It can derive from Rhodia, Inc.; Atlox It can derive from Uniqema; Caloxylate It can derive from Pilot Chemical Co.; Canasol It can derive from Canamex Quimicos S.A de C.v; Canasol It can derive from Canamex Quimicos S.A de C.v;Canasol It can derive from Canamex Quimicos S.A de C.v; Canasol OF It can derive from Canamex Quimicos S.A de C.v; Canasol OF It can derive from Canamex Quimicos S.A de C.v; Canasol OF It can derive from Canamex Quimicos S.A de C.v; Chemax It can derive from Chemax Performance Solutions;Chemax It can derive from Chemax Performance Solutions; Chemax It can derive from Chemax Performance Solutions; DeSonic It can derive from Crompton Corp.; DeSonic It can derive from Crompton Corp.; DeSonic It can derive from Crompton Corp.;DeSonic It can derive from Crompton Corp.; DeSonic It can derive from Crompton Corp.; DeSonic It can derive from Crompton Corp.; DeSonic It can derive from Crompton Corp.; DeSonic It can derive from Crompton Corp.;DeSonic It can derive from Crompton Corp.; DeSonic It can derive from Crompton Corp.; DeSonic It can derive from Crompton Corp.; DeSonic It can derive from Crompton Corp.; Eccoscour It can derive from Eastern Color & Chemical Co.;Eccoterge It can derive from Eastern Color & Chemical Co.; Emulsifier It can derive from Ethox Chemicals, LLC; Geronol It can derive from Rhodia, Inc.; Gradonic It can derive from Graden Chemical Co.Inc.; Hetoxide It can derive from Global-Seven, Inc.;Hetoxide It can derive from Global-Seven, Inc.; Hostapal It can derive from ClariantCorporation; Hostapal It can derive from Clariant Corporation; Igepal It can derive from Rhodia, Inc.; Igepal It can derive from Rhodia, Inc.;Igepal It can derive from Rhodia, Inc.; Igepal It can derive from Rhodia, Inc.; Lipocol NP-9 It can derive from Lipo Chemicals, Inc.; Macol It can derive from BASF Corp.; Marlophen It can derive from Sasol North America Inc.;Marlophen P It can derive from Sasol North America Inc.; Surfonic It can derive from Huntsman LLC; Surfonic It can derive from Huntsman LLC; Surfonic It can derive from Huntsman LLC; Syn Fac It can derive from Milliken Chemical;Syn Fac It can derive from Milliken Chemical; Triton It can derive from Dow Chemical Company; Trycol It can derive from Cognis Corporation; Trycol It can derive from Cognis Corporation; Trycol It can derive from Cognis Corporation;Trycol It can derive from Cognis Corporation; Trycol It can derive from Cognis Corporation; Witbreak It can derive from Akzo Nobel Surface Chemistry LLC; Witbreak It can derive from Crompton Corp.; And Witconol NP It can derive from Akzo Nobel Surface Chemistry LLC;DeIonic DeIonic DeIonic DeIonic DeIonic DeIonic DeIonic DeIonic DeIonic DeSonic DeSonic DeSonic DeSonic Igepal Igepal Igepal Igepal Igepal Igepal Igepal Igepal Igepal Igepal Igepal Igepal Igepal Igepal Igepal Igepal Igepal CO-630 Igepal Igepal Igepal Igepal Igepal Igepal Igepal Igepal Igepal Igepal Igepal Igepal Igepal Igepal CO-990 Igepal Igepal Igepal Igepal Igepal Igepal Igepal DM-970 Igepal Igepal Igepal Igepal Norfox Norfox Norfox Norfox Norfox Norfox Norfox Norfox Norfox Norfox Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Triton Triton Triton Triton Triton X-165 Triton Triton X-305 Triton Triton X-405 Triton And Triton X-705
ethoxylation aryl phenol, include but not limited to:
Soprophor it can derive from Rhodia, Inc.; Soprophor it can derive from Rhodia, Inc.; Soprophor it can derive from Rhodia, Inc.; Witconol it can derive from Akzo Nobel Surface Chemistry LLC; Witconol it can derive from Akzo Nobel Surface Chemistry LLC; Witconol it can derive from Akzo Nobel Surface Chemistry LLC; Cedepal cedepal cedepal cedepal cedepal cedepal cedepal cedepal cedepal cedepal cedepal cedepal cedepal cedepal cedepal cedepal cedepal cedepal cedepal and Cedepal
ethoxylated fatty acid, include but not limited to:
Aldo It can derive from Lonza Inc.; Alkamuls It can derive from Rhodia, Inc.; Armotan It can derive from Akzo Nobel Surface Chemistry LLC; Cerasynt It can derive from International Specialty Products/IS; Cerasynt It can derive from International Specialty Products/IS;Crystal Inhibitor No. It can derive from Harcros Chemicals Inc.; DeThox Acid It can derive from DeForest Enterprises, Inc.; DeThox Acid It can derive from DeForest Enterprises, Inc.; Ethofat It can derive from Akzo Nobel Surface Chemistry LLC; Hydropalat It can derive from Cognis Corporation;Lipo It can derive from Lipo Chemicals, Inc.; Lipopeg2 It can derive from Lipo Chemicals, Inc.; Lipopeg4 It can derive from Lipo Chemicals, Inc.; Lipopeg It can derive from Lipo Chemicals, Inc.; Lipopeg It can derive from Lipo Chemicals, Inc.;Lipopeg It can derive from Lipo Chemicals, Inc.; Lipopeg It can derive from Lipo Chemicals, Inc.; Lipopeg It can derive from Lipo Chemicals, Inc.; Lipopeg6000 It can derive from Lipo Chemicals, Inc.; Lumulse It can derive from Lambent Technologies Corp.;Lumulse It can derive from Lambent Technologies Corp.; Lumulse It can derive from Lambent Technologies Corp.; Lumulse It can derive from Lambent Technologies Corp.; Lumulse It can derive from Lambent Technologies Corp.; Lumulse It can derive from Lambent Technologies Corp.;Magrabar It can derive from Magrabar Chemical Corp.; Magrabar It can derive from Magrabar Chemical Corp.; Magrabar It can derive from Magrabar Chemical Corp.; Magrabar It can derive from Magrabar Chemical Corp.; Magrabar It can derive from Magrabar Chemical Corp.;Magrabar It can derive from Magrabar Chemical Corp.; Magrabar It can derive from Magrabar Chemical Corp.; Magrabar It can derive from Magrabar Chemical Corp.; Magrabar It can derive from Magrabar Chemical Corp.; Magrabar It can derive from Magrabar Chemical Corp.;Magrabar It can derive from Magrabar Chemical Corp.; Magrabar It can derive from Magrabar Chemical Corp.; Magrabar It can derive from Magrabar Chemical Corp.; Magrabar It can derive from Magrabar Chemical Corp.; Magrabar It can derive from Magrabar Chemical Corp.;Magrabar It can derive from Magrabar Chemical Corp.; Magrabar It can derive from Magrabar Chemical Corp.; Magrabar It can derive from Magrabar Chemical Corp.; Mapeg It can derive from BASF Corp.; Marlowet It can derive from Sasol North America Inc.;Naturechem It can derive from Inc.; PG No. It can derive from Hart Chemical Corp.; Renex It can derive from Uniqema; Ritox It can derive from RITA Corp.; Ritox It can derive from RITA Corp.;Ritox It can derive from RITA Corp.; Surfax It can derive from Houghton International Inc.; Tego Acid S40 It can derive from Goldschmidt Chemical Corp.; Tego Acid S100 It can derive from Goldschmidt Chemical Corp.; Tween It can derive from Uniqema;Volpo It can derive from Croda Inc.; Alkamuls DeThox Acid DeThox Acid DeThox Acid DeThox Acid DeThox Acid DeThox Acid Emerest Emerest Emerest Ethox Ethox Ethox Ethox Ethox Ethox Ethox Ethox Ethox Ethox Ethox Ethox Flexricin Flexricin Genapol Lumulse Lumulse Lumulse Lumulse PEG Lumulse PEG1450 Lumulse PEG Lumulse Lumulse POE (2) Oleyl Magrabar Mapeg200 Mapeg400 Mapeg400 Mapeg Mapeg Mapeg Marlox FK Marlox MO Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic And Surfonic
ethoxylated fat ester or oil (animal and plant oil), include but not limited to:
Acconon It can derive from Abitec Corporation; Acconon It can derive from Abitec Corporation; Acconon It can derive from Abitec Corporation; Aldosperse40/60 It can derive from Lonza Inc.; Aldosperse It can derive from Lonza Inc.;Aldosperse MS-20 It can derive from Lonza Inc.; Alkamuls It can derive from Rhodia, Inc.; Alkamuls It can derive from Rhodia, Inc.; Alkamuls It can derive from Rhodia, Inc.; Arlatone It can derive from Uniqema;Arlatone It can derive from Uniqema; Atlas It can derive from Uniqema; Atlas It can derive from Uniqema; Atlas It can derive from Uniqema; Atlas It can derive from Uniqema; Atlas It can derive from Uniqema;Atlas It can derive from Uniqema; Atlas It can derive from Uniqema; It can derive from Uniqema; Atlas It can derive from Uniqema; Capmul It can derive from Abitec Corporation; Chemonic It can derive from Chemron Corp.; Chemonic It can derive from Chemron Corp.; Chemonic It can derive from Chemron Corp.; Cirrasol It can derive from Uniqema; Cremophor CO It can derive from BASF Corp.; Cremophor CO It can derive from BASF Corp.;Cremophor It can derive from BASF Corp.; Cremophor It can derive from BASF Corp.; Cremophor It can derive from BASF Corp.; Crovol It can derive from Croda Inc.; Crovol It can derive from Croda Inc.;Crovol It can derive from Croda Inc.; Crovol It can derive from Croda Inc.; Cutina It can derive from Cognis Canada Corp.; Dacospin It can derive from Cognis Corporation; Dehymuls It can derive from Cognis Corporation;DeSonic It can derive from Crompton Corp.; DeSonic It can derive from Crompton Corp.; DeSonic It can derive from Crompton Corp.; Durfax It can derive from Loders Croklaan U.S.A.; Durfax It can derive from Loders Croklaan U.S.A.;Durfax It can derive from Loders Croklaan U.S.A.; Durfax It can derive from Loders Croklaan U.S.A.; Eccoterge It can derive from Eastern Color & Chemical Co.; Emulpon It can derive from Akzo Nobel Surface Chemistry LLC; Emulpon It can derive from Akzo Nobel Surface Chemistry LLC;Emulsogen It can derive from Clariant Corporation; Emulsogen HCO It can derive from Clariant Corporation; Emulsogen HCO It can derive from Clariant Corporation; Emulsynt It can derive from International Specialty Products/IS; Ethox It can derive from Ethox Chemicals, LLC;Eumulgin It can derive from Cognis Canada Corp.; Genapol It can derive from Clariant Corporation; Glycosperse It can derive from Lonza Inc.; Glycosperse It can derive from Lonza Inc.; Glycosperse It can derive from Lonza Inc.;GlycosperseO-20 It can derive from Lonza Inc.; Glycosperse It can derive from Lonza Inc.; Glycosperse S-20 It can derive from Lonza Inc.; Glycosperse It can derive from Lonza Inc.; Glycosperse TS-20 It can derive from Lonza Inc.;Hetan It can derive from Global-Seven, Inc.; Hetan It can derive from Global-Seven, Inc.; Hetan It can derive from Global-Seven, Inc.; Hetoxide It can derive from Global-Seven, Inc.; Hetoxide It can derive from Global-Seven, Inc.;Hetoxide It can derive from Global-Seven, Inc.; Hetoxide It can derive from Global-Seven, Inc.; Hetoxide It can derive from Global-Seven, Inc.; Hetoxide It can derive from Global-Seven, Inc.; Hetoxide It can derive from Global-Seven, Inc.;Hetoxide It can derive from Global-Seven, Inc.; Hetoxide It can derive from Global-Seven, Inc.; Ice No. It can derive from Loders Croklaan U.S.A.; Incrocas It can derive from Croda Inc.; Lexol It can derive from Inolex Chemical Co.;Lexol It can derive from Inolex Chemical Co.; Lipocol It can derive from Lipo Chemicals, Inc.; Lipocol It can derive from Lipo Chemicals, Inc.; Lipocol O-3 It can derive from Lipo Chemicals, Inc.; Lipopeg It can derive from Lipo Chemicals, Inc.;Lipopeg It can derive from Lipo Chemicals, Inc.; Lipopeg It can derive from Lipo Chemicals, Inc.; Lipovol It can derive from Lipo Chemicals, Inc.; Lonzest It can derive from Lonza Inc.; Lonzest It can derive from Lonza Inc.;Lonzest It can derive from Lonza Inc.; Lonzest It can derive from Lonza Inc.; Lonzest It can derive from Lonza Inc.; Lumulse It can derive from Lambent Technologies Corp.; Lumulse It can derive from Lambent Technologies Corp.;Lumulse POE (7) It can derive from Lambent Technologies Corp.; Lumulse POE (12) It can derive from Lambent Technologies Corp.; Lumulse POE (40) MS It can derive from Lambent Technologies Corp.; Marlowet It can derive from Sasol North America Inc.; Marlowet It can derive from Sasol North America Inc.;Marlowet R It can derive from Sasol North America Inc.; Marlowet R It can derive from Sasol North America Inc.; Mazol80 It can derive from BASF Corp.; Nonionic Emulsifier It can derive from Werner G.Smith Inc.; Oronal It can derive from Seppic Inc.;Polyderm It can derive from Alzo International, Inc.; Polyderm It can derive from Alzo International, Inc.; Rewoderm LI It can derive from Goldschmidt Chemical Corp.; Ritapeg150 It can derive from RITA Corp.; Softigen It can derive from Sasol North America Inc.;Surfactol It can derive from Inc.; Surfactol It can derive from Inc.; Syn Lube It can derive from Milliken Chemical; Syn Lube It can derive from Milliken Chemical;Syn Lube It can derive from Milliken Chemical; Syn Lube It can derive from Milliken Chemical; T-Det It can derive from Harcros Chemicals Inc.; T-Det It can derive from Harcros Chemicals Inc.; Tally100 It can derive from Loders Croklaan U.S.A.;Uniperol It can derive from BASF Corp.; Acconon Chemax Chemax Chemax Chemax Chemax Chemax Chemax Chemax Chemax Chemax Chemax Chemax E200 Chemax E200 Chemax E400 Chemax E400 Chemax E600 Chemax E600 Chemax E1000 Chemax E1000 Chemax E200 Chemax E400 Chemax E600 Chemax Chemax Chemax Chemax Chemax Chemax Colalube Colalube Colalube Colalube Colalube Colalube Colalube DePeg DePeg DePeg DePeg DePeg DePeg Ethox Ethox Ethox Ethox Ethox Ethox Ethox Ethox Hetoxide Hetoxide Hetoxide Hetoxide Hetoxide Hetoxide Hetoxide Lipo GMS Lipo Polyglycol Lipo Polyglycol Lipo Polyglycol Lipo Polyglycol Lipo Polyglycol Lipo Polyglycol Surfonic Surfonic Surfonic Surfonic Surfonic Surfonic Tagat Tagat CH Tagat L Tagat Tagat S And Tally100
fatty ester, include but not limited to:
Actralube-Syn it can derive from Georgia-Pacific Corp.; Atlas it can derive from Uniqema; Atlas it can derive from Uniqema; Atlasol Base Oil it can derive from Atlas Refinery Inc.; Base it can derive from Keil Chemical; Base it can derive from Keil Chemical; Cerasynt it can derive from International Specialty Products/IS; Dermol it can derive from Alzo International, Inc.; Kemester it can derive from Crompton Corp.; Lactipol it can derive from Canamex Quimicos S.A de C.v; Magrabar it can derive from Magrabar Chemical Corp.; Mayco Base it can derive from Dover Chemical Corp.; Methyl it can derive from Hart Chemical Corp.; Pationic it can derive from RITA Corp.; Pationic it can derive from RITA Corp.; Pationic it can derive from RITA Corp.; Pationic it can derive from RITA Corp.; Pationic it can derive from RITA Corp.; Pationic it can derive from RITA Corp.; it can derive from RITA Corp.; Tego Alkanol CS it can derive from Goldschmidt Chemical Corp.; Tego Alkanol L23 it can derive from Goldschmidt Chemical Corp.; Tego Alkanol it can derive from Goldschmidt Chemical Corp.; Tego Alkanol S20 it can derive from Goldschmidt Chemical Corp.; Triemulsifier600 it can derive from Tri-Tex inc.; Santone santone3-1-S santone and Santone
glyceride, include but not limited to:
Agro#9Wint It can derive from Lambent Technologies Corp.; Ahcovel Base It can derive from Uniqema; Aldo HMS It can derive from Lonza Inc.; Aldo It can derive from Lonza Inc.; Aldo MLD It can derive from Lonza Inc.;Aldo MO It can derive from Lonza Inc.; Aldo It can derive from Lonza Inc.; Aldo MS It can derive from Lonza Inc.; Aldo MS LG It can derive from Lonza Inc.; Aldo It can derive from Lonza Inc.; Aldo MSD It can derive from Lonza Inc.; Aldosperse O-20 It can derive from Lonza Inc.; Aldosperse TS-20 It can derive from Lonza Inc.; Aldosperse TS-40 It can derive from Lonza Inc.; Arlacel It can derive from Uniqema; Arlacel It can derive from Uniqema;Capmul It can derive from Abitec Corporation; Capmul It can derive from Abitec Corporation; Caprol It can derive from Abitec Corporation; Caprol It can derive from Abitec Corporation; Caprol It can derive from Abitec Corporation;Caprol It can derive from Abitec Corporation; Caprol It can derive from Abitec Corporation; Caprol It can derive from Abitec Corporation; Caprol It can derive from Abitec Corporation; Cerasynt It can derive from International Specialty Products/IS;Cerasynt It can derive from International Specialty Products/IS; Cerasynt It can derive from International Specialty Products/IS; Cerasynt It can derive from International Specialty Products/IS; Cerasynt It can derive from International Specialty Products/IS; Chemsperse It can derive from Chemron Corp.;Cremophor It can derive from BASF Corp.; Cremophor It can derive from BASF Corp.; Cremophor It can derive from BASF Corp.; Cutina It can derive from Cognis Canada Corp.; Dehymuls It can derive from Cognis Corporation;Dermol It can derive from Alzo International, Inc.; Dermol It can derive from Alzo International, Inc.; Dermol It can derive from Alzo International, Inc.; Dermol It can derive from Alzo International, Inc.; Dermol It can derive from Alzo International, Inc.;Dermolan It can derive from Alzo International, Inc.; Drewmulse It can derive from Stepan Company; Drewpol It can derive from Stepan Company; Durlac100 It can derive from Loders Croklaan U.S.A.; It can derive from Loders Croklaan U.S.A.;Dynasan It can derive from Sasol North America Inc.; It can derive from Loders Croklaan U.S.A.; It can derive from Keil Chemical; Emerest It can derive from Cognis Corporation; Emerest It can derive from Cognis Corporation;Empilan It can derive from Huntsman LLC; Genapol It can derive from Clariant Corporation; Hostacerin It can derive from Clariant Corporation; Hostacerin It can derive from Clariant Corporation; Hostacerin It can derive from Clariant Corporation;Hostacerin It can derive from Clariant Corporation; Ice No. It can derive from Loders Croklaan U.S.A.; Imwitor It can derive from Sasol North America Inc.; Imwitor780 It can derive from Sasol North America Inc.; Imwitor960 It can derive from Sasol North America Inc.;Isolan GI It can derive from Goldschmidt Chemical Corp.; Isolan GO It can derive from Goldschmidt Chemical Corp.; Kemester It can derive from Crompton Corp.; Kemester It can derive from Crompton; Kemester It can derive from Crompton Corp.;Kemester It can derive from Crompton Corp.; Lamecreme DGE It can derive from Cognis Corporation; Lexemul It can derive from Inolex Chemical Co.; Lexemul It can derive from Inolex Chemical Co.; Lexemul It can derive from Inolex Chemical Co.;Lexemul It can derive from Inolex Chemical Co.; Lexemul It can derive from Inolex Chemical Co.; Lexemul It can derive from Inolex Chemical Co.; Lipomulse It can derive from Lipo Chemicals, Inc.; Lumulse GML It can derive from Lambent Technologies Corp.;Lumulse It can derive from Lambent Technologies Corp.; Lumulse GMR It can derive from Lambent Technologies Corp.; Lumulse GMT It can derive from Lambent Technologies Corp.; Magrabar It can derive from Magrabar Chemical Corp.; Magrabar It can derive from Magrabar Chemical Corp.;Magrabar It can derive from Magrabar Chemical Corp.; Magrabar It can derive from Magrabar Chemical Corp.; Magrabar It can derive from Magrabar Chemical Corp.; Mazol It can derive from BASF Corp.; Mazol It can derive from BASF Corp.;Mazol It can derive from BASF Corp.; Mazol It can derive from BASF Corp.; Miglyol It can derive from Sasol North America Inc.; Norfox It can derive from Norman, Fox & Co.; Schercemol It can derive from Inc.; It can derive from Goldschmidt Chemical Corp.; Tegin4100 It can derive from Goldschmidt Chemical Corp.; Tegin M It can derive from Goldschmidt Chemical Corp.; Tegin It can derive from Goldschmidt Chemical Corp.;Teginacid It can derive from Goldschmidt Chemical Corp.; Tego Cosmo It can derive from Goldschmidt Chemical Corp.; Wickenol It can derive from Alzo International, Inc.; Witconol It can derive from Akzo Nobel Surface Chemistry LLC; Witconol It can derive from Crompton Corp.;Witconol It can derive from Crompton Corp.; Witconol It can derive from Crompton Corp.; Witconol It can derive from Crompton Corp.; Witconol It can derive from Crompton Corp.; Witconol It can derive from Crompton Corp.;Alkamuls Dur-Em Dur-Em Dur-Em Dur-Em Dur-Em Glicepol Glicepol Glicepol GMS Polyaldo Polyaldo Polyaldo Polyaldo Surfonic And
diol ester, include but not limited to:
Alkamuls600 It can derive from Rhodia, Inc.; Alkamuls It can derive from Rhodia, Inc.; Atlas It can derive from Atlas Refinery Inc.; Cerasynt It can derive from International Specialty Products/IS; Cerasynt It can derive from International Specialty Products/IS;Cerasynt It can derive from International Specialty Products/IS; Cerasynt It can derive from International Specialty Products/IS; Chemsperse It can derive from Chemron Corp.; Chemsperse It can derive from Chemron Corp.; Colonial It can derive from Colonial Chemical Co.;DeMuls It can derive from DeForest Enterprises, Inc.; Eccoterge It can derive from Eastern Color & Chemical Co.; Emerest It can derive from Cognis Corporation; Ethox It can derive from Ethox Chemicals, LLC; Ethox It can derive from Ethox Chemicals, LLC;Ethox It can derive from Ethox Chemicals, LLC; Ethox It can derive from Ethox Chemicals, LLC; Fizul It can derive from Finetex Inc.; Genapol It can derive from Clariant Corporation; Genapol TS It can derive from Clariant Corporation;Hostacerin It can derive from Clariant Corporation; Inversol It can derive from Keil Chemical; Kemester It can derive from Crompton Corp.; Kemester It can derive from Crompton Corp.; Kemester It can derive from Crompton Corp.;Kemester5221 It can derive from Crompton Corp.; Kemester It can derive from Crompton Corp.; Lexemul It can derive from Inolex Chemical Co.; Lexemul It can derive from Inolex Chemical Co.; Lexemul It can derive from Inolex Chemical Co.;Lipo It can derive from Lipo Chemicals, Inc.; Lipo It can derive from Lipo Chemicals, Inc.; Lipo It can derive from Lipo Chemicals, Inc.; Liposorb It can derive from Lipo Chemicals, Inc.;Liposorb It can derive from Lipo Chemicals, Inc.; Lumulse It can derive from Lambent Technologies Corp.; Mackester It can derive from The McIntyre Group; Mackester It can derive from The McIntyre Group; Mackester It can derive from The McIntyre Group;Mackester It can derive from The McIntyre Group; Magrabar It can derive from Magrabar Chemical Corp.; Mapeg6000 It can derive from BASF Corp.; Marlowet It can derive from Sasol North America Inc.; Monalube It can derive from Uniqema;Monalube It can derive from Uniqema; Monalube It can derive from Uniqema; Monalube It can derive from Uniqema; Monalube It can derive from Uniqema; Monalube It can derive from Uniqema; Naturechem It can derive from Inc.; Polycastorol It can derive from Magrabar Chemical Corp.; Polytex It can derive from Lipo Chemicals, Inc.; Ritasynt It can derive from RITA Corp.; Ross Chem PEG600 It can derive from Lubrizol Foam Control Additives;Schercemol It can derive from Inc.; Sponto It can derive from Crompton Corp.; Tegin It can derive from Goldschmidt Chemical Corp.; Witbreak It can derive from Akzo Nobel Surface Chemistry LLC;Witbreak It can derive from Crompton Corp.; Witbreak It can derive from Akzo Nobel Surface Chemistry LLC; Witbreak It can derive from Crompton Corp.; Witbreak It can derive from Akzo Nobel Surface Chemistry LLC; Witbreak It can derive from Crompton Corp.;Witconol It can derive from Crompton Corp.; Witconol It can derive from Akzo Nobel Surface Chemistry LLC; Witconol It can derive from Akzo Nobel Surface Chemistry LLC; Witconol It can derive from Crompton Corp.; Witconol It can derive from Crompton Corp.;Ethox Ethox Pegosperse Pegosperse Pegosperse Pegosperse Pegosperse Pegosperse200 Pegosperse Pegosperse Pegosperse Pegosperse Pegosperse Pegosperse Pegosperse Pegosperse Pegosperse Pegosperse Pegosperse Pegosperse Protegin Protegin Protegin And Protegin
lanoline radical derivative, include but not limited to:
Amerchol It can derive from Amerchol Corp.; Amerchol It can derive from Amerchol Corp.; Amerlate It can derive from Amerchol Corp.; Amerlate It can derive from Amerchol Corp.; Barre Common It can derive from RITA Corp.;Cholesterol It can derive from Croda Inc.; Crodalan It can derive from Croda Inc.; Crodalan It can derive from Croda Inc.; Emery It can derive from Cognis Canada Corp.; Emery It can derive from Cognis Corporation;Emery It can derive from Cognis Canada Corp.; Emery It can derive from Cognis Corporation; Forlan It can derive from RITA Corp.; Forlan It can derive from RITA Corp.; Laneto It can derive from RITA Corp.;Laneto It can derive from RITA Corp.; Laneto It can derive from RITA Corp.; Lanfrax It can derive from Cognis Canada Corp.; Lanfrax It can derive from Cognis Corporation; Lanogel It can derive from Amerchol Corp.; It can derive from Lipo Chemicals, Inc.; Lipolan It can derive from Lipo Chemicals, Inc.; It can derive from Amerchol Corp.; Polychol It can derive from Croda Inc.; Polychol It can derive from Croda Inc.; It can derive from RITA Corp.; It can derive from RITA Corp.; It can derive from RITA Corp.; It can derive from RITA Corp.; It can derive from RITA Corp.; Ritalan It can derive from RITA Corp.;Ritalan It can derive from RITA Corp.; It can derive from RITA Corp.; Ritawax It can derive from RITA Corp.; Ritawax It can derive from RITA Corp.; Solan/Solan50/Super It can derive from Croda Inc.;Super It can derive from Croda Inc.; Supersat It can derive from RITA Corp.; And Supersat It can derive from RITA Corp.; Lecithin and lecithin derivative, include but not limited to: It can derive from American Lecithin Co.; It can derive from Archer Daniels Midland Company;Lexin It can derive from American Lecithin Co.; And It can derive from American Lecithin Co..
lignin and lignin derivative, include but not limited to:
Diwatex XP it can derive from Borregaard Lignotech USA Inc.; Dynasperse it can derive from Borregaard Lignotech USA Inc.; Indulin it can derive from MeadWestvaco Corp.; Indulin it can derive from MeadWestvaco Corp.; Indulin it can derive from MeadWestvaco Corp.; Lignosol it can derive from Borregaard Lignotech USA Inc.; Lignosol it can derive from Borregaard Lignotech USA Inc.; Marasperse52 it can derive from Borregaard Lignotech USA Inc.; Marasperse it can derive from Borregaard Lignotech USA Inc.; Marasperse it can derive from Borregaard Lignotech USA Inc.; And Ufoxane it can derive from Borregaard Lignotech USA Inc..
methyl ester, include but not limited to:
E.B.Cleaner it can derive from Eastern Color & Chemical Co.; Oleocal it can derive from Lambent Technologies Corp.; Oleocal it can derive from Lambent Technologies Corp.; Oleocal it can derive from Lambent Technologies Corp.; And Oleocal it can derive from Lambent Technologies Corp..
monoglyceride and derivant, include but not limited to:
Dynacet it can derive from Sasol North America Inc.; Hetsorb it can derive from Global-Seven, Inc.; Imwitor it can derive from Sasol North America Inc.; Imwitor it can derive from Sasol North America Inc.; Imwitor it can derive from Sasol North America Inc.; Imwitor it can derive from Sasol North America Inc.; Imwitor it can derive from Sasol North America Inc.; Imwitor it can derive from Sasol North America Inc.; Kemester it can derive from Crompton Corp.; Kemester it can derive from Crompton Corp.; Magrabar it can derive from Magrabar Chemical Corp.; Magrabar it can derive from Magrabar Chemical Corp.; Magrabar it can derive from Magrabar Chemical Corp.; Magrabar it can derive from Magrabar Chemical Corp.; Monalube it can derive from Uniqema; Monoglycerides Glyceryl Monestearate Archer Daniels Midland Company; Rita it can derive from RITA Corp.; Ritamulse it can derive from RITA Corp.; Softigen it can derive from Sasol North America Inc.; And Tally100 it can derive from Loders Croklaan U.S.A..
polyethylene Glycol, include but not limited to:
Emulgade PL it can derive from Cognis Corporation; Lumulse it can derive from Lambent Technologies Corp.; Rhodasurf it can derive from Rhodia, Inc.; Rhodasurf it can derive from Rhodia, Inc.; And Witconol it can derive from Akzo Nobel Surface Chemistry LLC..
polymeric surfactant, include but not limited to:
Acritamer It can derive from RITA Corp.; Ag-Rho It can derive from Rhodia, Inc.; APG325N It can derive from Cognis Corporation; Aristoflex It can derive from Clariant Corporation; Aristoflex It can derive from Clariant Corporation;Burco It can derive from Burlington Chemical Inc.; Burco It can derive from Burlington Chemical Inc.; Chemccinate It can derive from Chemron Corp.; Cosmedia Guar It can derive from Cognis Corporation; Gantrez It can derive from International Specialty Products/IS; Glucopon220 It can derive from Cognis Corporation; Glucopon225 It can derive from Cognis Corporation; Glucopon425 It can derive from Cognis Corporation; Glucopon600 It can derive from Cognis Corporation;Glucopon625 It can derive from Cognis Corporation; Pemulen It can derive from Inc.; Pemulen It can derive from Inc.; Pemulen It can derive from Inc.; Pemulen It can derive from Inc.; Plantacare It can derive from Cognis Corporation; Plantapon LGC It can derive from Cognis Corporation; Plantaren It can derive from Cognis Corporation; Plantaren It can derive from Cognis Corporation; Viscolam AT It can derive from RITA Corp.; Viscolam AT It can derive from RITA Corp.; Viscolam AT It can derive from RITA Corp.; Viscolam MAC It can derive from RITA Corp.;Viscolam SMC It can derive from RITA Corp.; Witbreak It can derive from Crompton Corp.; And WSI It can derive from Jacam Chemicals, L.L.C..
propoxylation and ethoxylated fatty acid, alcohol or alkyl phenol, include but not limited to:
Antarox It can derive from Rhodia, Inc.; Antarox It can derive from Rhodia, Inc.; Burcomul It can derive from Burlington Chemical Inc.; Burcoterge It can derive from Burlington Chemical Inc.; Chemal It can derive from Chemax Performance Solutions; Chemal It can derive from Chemax Performance Solutions; Dehypon It can derive from Cognis Canada Corp.; Dehypon It can derive from Cognis Corporation;Dehypon It can derive from Cognis Canada Corp.; Dehypon It can derive from Cognis Corporation; DeIonic100 It can derive from DeForest Enterprises, Inc.; DeIonic LF-60 It can derive from DeForest Enterprises, Inc.; Empiderm It can derive from Huntsman LLC;Ethylan It can derive from Akzo Nobel Surface Chemistry LLC; Ethylan It can derive from Akzo Nobel Surface Chemistry LLC; Ethylan It can derive from Akzo Nobel Surface Chemistry LLC; Genapol It can derive from Clariant Corporation; Genapol It can derive from Clariant Corporation;Genapol It can derive from Clariant Corporation; Genapol EP It can derive from Clariant Corporation; Genapol EP It can derive from Clariant Corporation; Genapol EP It can derive from Clariant Corporation; Genapol It can derive from Clariant Corporation;Kieralon It can derive from BASF Corp.; Lumisolve CSA-80 It can derive from Lambent Technologies Corp.; Marlowet It can derive from Sasol North America Inc.; Marlox FK It can derive from Sasol North America Inc.; Marlox MO It can derive from Sasol North America Inc.;Marlox S It can derive from Sasol North America Inc.; Nonatell It can derive from Tomah Inc.; Nonatell It can derive from Tomah Inc.; Nonatell It can derive from Tomah Inc.; Nonatell It can derive from Tomah Inc.; Nonatell It can derive from Tomah Inc.; Nonatell It can derive from Tomah Inc.; Nonatell It can derive from Tomah Inc.; Nonatell It can derive from Tomah Inc.; Nonatell It can derive from Tomah Inc.; Nonatell It can derive from Tomah Inc.; Nonatell It can derive from Tomah Inc.; Norfox It can derive from Norman, Fox & Co.;Procetyl It can derive from Croda Inc.; Sandoxylate SX It can derive from Clariant Corporation; Sandoxylate SX It can derive from Clariant Corporation; Surfonic It can derive from Huntsman LLC; Surfonic It can derive from Huntsman LLC;Surfonic It can derive from Huntsman LLC; Surfonic It can derive from Huntsman LLC; T-Det It can derive from Harcros Chemicals Inc.; T-Det It can derive from Harcros Chemicals Inc.; Tergitol Min-Foam It can derive from Dow Chemical Company;Tergitol Min-Foam It can derive from Dow Chemical Company; Triton It can derive from Dow Chemical Company; Triton It can derive from Dow Chemical Company; Triton It can derive from Dow Chemical Company; Witconol It can derive from Akzo Nobel Surface Chemistry LLC;Witconol It can derive from Akzo Nobel Surface Chemistry LLC; Witconol It can derive from Akzo Nobel Surface Chemistry LLC; Witconol It can derive from Akzo Nobel Surface Chemistry LLC; Chemal Chemal Chemal LFL-28 Chemal DeIonic DeIonic DeIonic DeIonic DeIonic DeIonic DeIonic DeIonic And Soprophor
protein-based surfactant, include but not limited to:
AminoFoam It can derive from Croda Inc.; Amiter It can derive from Ajinomoto USA, Inc.; Amiter It can derive from Ajinomoto USA, Inc.; Amiter It can derive from Ajinomoto USA, Inc.; Lamepon It can derive from Cognis Canada Corp.;Lamepon It can derive from Cognis Corporation; Maypon It can derive from Inolex Chemical Co.; May-Tein It can derive from Maybrook, Inc.; May-Tein It can derive from Maybrook, Inc.; May-Tein It can derive from Maybrook, Inc.;May-Tein It can derive from Maybrook, Inc.; Plantapon It can derive from Cognis Corporation; Proteol It can derive from Seppic Inc.; Proteol It can derive from Seppic Inc.; Pyroter It can derive from Ajinomoto USA, Inc.;Pyroter It can derive from Ajinomoto USA, Inc.; Supro-Tein It can derive from Maybrook, Inc.; And Supro-Tein It can derive from Maybrook, Inc.; Sarcosine derivative, includes but not limited to Crodasinic It can derive from Croda Inc.; Vanseal It can derive from R.T.Vanderbilt Co.Inc.;Vanseal It can derive from R.T.Vanderbilt Co.Inc.; Vanseal It can derive from R.T.Vanderbilt Co.Inc.; Vanseal It can derive from R.T.Vanderbilt Co.Inc.; Vanseal It can derive from R.T.Vanderbilt Co.Inc.; And Vanseal It can derive from R.T.Vanderbilt Co.Inc.; Silicone base surfactant, includes but not limited to: It can derive from Goldschmidt Chemical Corp.; Abil Care It can derive from Goldschmidt Chemical Corp.; Abil EM It can derive from Goldschmidt Chemical Corp.; Abil EM It can derive from Goldschmidt Chemical Corp.; Abil It can derive from Goldschmidt Chemical Corp.;Dow Corning1248 It can derive from Dow Corning Corp.; Dow Corning Formulation Aid, it can derive from Dow Corning Corp.; Dow Corning Formulation Aid, it can derive from Dow Corning Corp.; Dow Corning Fluid, it can derive from Dow Corning Corp.; Monasil It can derive from Uniqema;Monasil It can derive from Uniqema; Monasil It can derive from Uniqema; Polyderm It can derive from Alzo International, Inc.; Troysol It can derive from Troy Corporation; Troysol It can derive from Troy Corporation; Dow Corning190 Dow Corning193 Dow Corning5103 Dow Corning FF400 Silwet Silwet Silwet Silwet Silwet Silwet Silwet Silwet Silwet Silwet Silwet Silwet Silwet Silwet Silwet Silwet Silwet Silwet And Silwet Sorbitan derivative, includes but not limited to: Alkamuls It can derive from Rhodia, Inc.; Alkamuls It can derive from Rhodia, Inc.; Alkamuls It can derive from Rhodia, Inc.; Arlacel It can derive from Uniqema;Arlacel It can derive from Uniqema; Arlacel It can derive from Uniqema; Arlacel It can derive from Uniqema; Arlacel It can derive from Uniqema; Armul It can derive from Crompton Corp.; Atlox It can derive from Uniqema; Atlox It can derive from Uniqema; Atlox It can derive from Uniqema; Canarcel It can derive from Canamex Quimicos S.A de C.v; Canarcel It can derive from Canamex Quimicos S.A de C.v; Canarcel It can derive from Canamex Quimicos S.A de C.v;Canarcel TW It can derive from Canamex Quimicos S.A de C.v; Canarcel TW It can derive from Canamex Quimicos S.A de C.v; Canarcel TW It can derive from Canamex Quimicos S.A de C.v; Coladet It can derive from Colonial Chemical Co.; Customulse It can derive from Custom Ingredients, Inc.;Dehymuls It can derive from Cognis Canada Corp.; DeSotan It can derive from Crompton Corp.; DeSotan It can derive from Crompton Corp.; DeSotan It can derive from Crompton Corp.; DeSotan It can derive from Crompton Corp.;Durfax It can derive from Loders Croklaan U.S.A.; Durfax It can derive from Loders Croklaan U.S.A.; Durfax It can derive from Loders Croklaan U.S.A.; Durtan It can derive from Loders Croklaan U.S.A.; Durtan It can derive from Loders Croklaan U.S.A.;Liposorb It can derive from Lipo Chemicals, Inc.; Liposorb It can derive from Lipo Chemicals, Inc.; Liposorb It can derive from Lipo Chemicals, Inc.; Liposorb It can derive from Lipo Chemicals, Inc.; Liposorb It can derive from Lipo Chemicals, Inc.;Liposorb It can derive from Lipo Chemicals, Inc.; Liposorb It can derive from Lipo Chemicals, Inc.; Liposorb It can derive from Lipo Chemicals, Inc.; Liposorb It can derive from Lipo Chemicals, Inc.; Liposorb It can derive from Lipo Chemicals, Inc.;Liposorb It can derive from Lipo Chemicals, Inc.; Liposorb It can derive from Lipo Chemicals, Inc.; Liposorb It can derive from Lipo Chemicals, Inc.; Lumisorb It can derive from Lambent Technologies Corp.; Lumisorb SMO It can derive from Lambent Technologies Corp.;Lumisorb SMS It can derive from Lambent Technologies Corp.; Lumisorb It can derive from Lambent Technologies Corp.; Lumisorb STS It can derive from Lambent Technologies Corp.; Lumisorb It can derive from Lambent Technologies Corp.; Magrabar It can derive from Magrabar Chemical Corp.;Magrabar It can derive from Magrabar Chemical Corp.; Magrabar It can derive from Magrabar Chemical Corp.; Magrabar It can derive from Magrabar Chemical Corp.; Miracare It can derive from Rhodia, Inc.; Ritabate It can derive from RITA Corp.;Ritabate It can derive from RITA Corp.; Ritabate It can derive from RITA Corp.; Ritabate It can derive from RITA Corp.; It can derive from BASF Corp.; Tego It can derive from Goldschmidt Chemical Corp.;Tego SML It can derive from Goldschmidt Chemical Corp.; Tego SMO80 It can derive from Goldschmidt Chemical Corp.; Tego SMO It can derive from Goldschmidt Chemical Corp.; Tego It can derive from Goldschmidt Chemical Corp.; Tego STO It can derive from Goldschmidt Chemical Corp.;Tween It can derive from Uniqema; Tween It can derive from Uniqema; Tween It can derive from Uniqema; Tween60 It can derive from Uniqema; Tween It can derive from Uniqema; Tween It can derive from Uniqema;Tween It can derive from Uniqema; Tween80 It can derive from Uniqema; Tween It can derive from Uniqema; Tween It can derive from Uniqema; Alkamuls Alkamuls Alkamuls Cremophor Cremophor Cremophor Cremophor Cremophor Crill Crill Crill Crillet Crillet Crillet Glycomul Glycomul Glycomul Glycomul Glycomul Hetsorb Hetsorb Hetsorb Hetsorb Hetsorb Hetsorb Lumisorb PSML-20 Lumisorb PSML-20 Lumisorb PSMO-20 Lumisorb PSMO-5 Lumisorb PSMS-20 Lumisorb PSTS-20 Lumisorb PSTT-20 Sorbax Sorbax Sorbax Sorbax Sorbax Sorbax Sorbax Sorbax Sorbax Sorbax Sorbax Sorbax Sorbax Span Span Span Span Span Span Span T-Maz T-Maz T-Maz T-Maz T-Maz T-Maz T-Maz T-Maz And T-Maz
sucrose and glucose ester and derivant, include but not limited to:
DeSulf GOS-P-60 it can derive from DeForest Enterprises, Inc.; Glucam E-20 it can derive from Amerchol Corp.; Glucamate it can derive from Amerchol Corp.; Glucamate it can derive from Amerchol Corp.; Glucate it can derive from Amerchol Corp.; Glucate it can derive from Amerchol Corp.; Glucopon425 it can derive from Cognis Corporation; Isolan it can derive from Goldschmidt Chemical Corp.; Mazon it can derive from BASF Corp.; Montanov it can derive from Seppic Inc.; Montanov it can derive from Seppic Inc.; Montanov it can derive from Seppic Inc.; it can derive from Rhodia, Inc.; Simulsol AS it can derive from Seppic Inc.; Simulsol SL it can derive from Seppic Inc.; Simulsol SL it can derive from Seppic Inc.; Simulsol SL it can derive from Seppic Inc.; Simulsol SL it can derive from Seppic Inc.; Suga Nate100 and it can derive from Colonial Chemical Co.; Tego Care it can derive from Goldschmidt Chemical Corp.; Tego Care CG it can derive from Goldschmidt Chemical Corp.; Tego Care it can derive from Goldschmidt Chemical Corp.; Tegosoft PSE141 it can derive from Goldschmidt Chemical Corp.; Tegotens G it can derive from Goldschmidt Chemical Corp.; Triton BG-10 it can derive from Dow Chemical Company; Triton CG-110 it can derive from Dow Chemical Company; Wickenol it can derive from Alzo International, Inc; Tego Care tego Care and Triton CG-110
Usable surface activity of the present invention also comprises:
Sorbitan esters;
Derive from the Pluronic of BASF;
Polysorbate20;
Polysorbate40;
Polysorbate60;
Polysorbate80;
Stearate;
Tristerin;
Isopropyl stearate;
Polyoxyl stearate (polyoxyl stearate);
Propylene glycol stearate;
Stearic acid sucrose ester;
Polyethylene Glycol;
Poly(ethylene oxide);
Poly(propylene oxide);
Poly(ethylene oxide)-poly(propylene oxide) copolymer;
Alcohol ethoxylate;
Alkylphenol ethoxylate;
Alkyl polyglucoside;
Alkyl polyglucoside;
Fatty alcohol;
Hydroxypropyl emthylcellulose;
Carboxymethyl cellulose;
Polyacrylic acid;
Carbomer;
Phospholipid;
Phosphatidylcholine; And
Phosphatidylserine.
Compositions of the present invention (especially emulsion) optionally comprises the activating agent such as Ciclosporin A, and can by but be not limited to following constituting:
Oleum Anisi Stellati and sorbitan esters;
Oleum Ricini and sorbitan esters;
Oleum Caryophylli and sorbitan esters;
Oleum Cinnamomi and sorbitan esters;
Oleum Cinnamomi and sorbitan esters;
Proportion is 0.90 to 0.95 oil and sorbitan esters;
Almond oil and sorbitan esters;
Semen Maydis oil and sorbitan esters;
Oleum Arachidis hypogaeae semen and sorbitan esters;
Oleum Gossypii semen and sorbitan esters;
Safflower oil and sorbitan esters;
Oleum maydis and sorbitan esters;
Semen Lini oil and sorbitan esters;
Oleum Brassicae campestris and sorbitan esters;
Soybean oil and sorbitan esters;
Olive oil and sorbitan esters;
Caraway seed oil and sorbitan esters;
Oil of rosemary and sorbitan esters;
Oleum Arachidis hypogaeae semen and sorbitan esters;
Oleum menthae and sorbitan esters;
Oleum helianthi and sorbitan esters;
Eucalyptus oil and sorbitan esters;
Oleum sesami and sorbitan esters;
Proportion is lower than 0.9 oil and sorbitan esters;
Mineral oil and sorbitan esters;
Fructus Coriandri oil and sorbitan esters;
Essential lavender oil and sorbitan esters;
Citronella oil and sorbitan esters;
Oleum juniperi e baccarae and sorbitan esters;
Fructus Citri Limoniae oil and sorbitan esters;
Orange oil and sorbitan esters;
Sage oil and sorbitan esters;
Semen Myristicae oil and sorbitan esters;
Tea tree oil and sorbitan esters;
Proportion is 0.95 to 1.07 oil and polysorbate80;
Oleum Anisi Stellati and polysorbate80;
Oleum Caryophylli and polysorbate80;
Oleum Cinnamomi and polysorbate80;
Oleum Cinnamomi and polysorbate80;
Proportion is 0.90 to 0.95 oil and polysorbate80;
Almond oil and polysorbate80;
Semen Maydis oil and polysorbate80;
Oleum Arachidis hypogaeae semen and polysorbate80;
Oleum Gossypii semen and polysorbate80;
Safflower oil and polysorbate80;
Oleum maydis and polysorbate80;
Semen Lini oil and polysorbate80;
Oleum Brassicae campestris and polysorbate80;
Soybean oil and polysorbate80;
Olive oil and polysorbate80;
Caraway seed oil and polysorbate80;
Oil of rosemary and polysorbate80;
Oleum Arachidis hypogaeae semen and polysorbate80;
Oleum menthae and polysorbate80;
Oleum helianthi and polysorbate80;
Eucalyptus oil and polysorbate80;
Oleum sesami and polysorbate80;
Proportion is lower than 0.9 oil and polysorbate80;
Mineral oil and polysorbate80;
Fructus Coriandri oil and polysorbate80;
Essential lavender oil and polysorbate80;
Citronella oil and polysorbate80;
Oleum juniperi e baccarae and polysorbate80;
Fructus Citri Limoniae oil and polysorbate80;
Orange oil and polysorbate80;
Sage oil and polysorbate80;
Semen Myristicae oil and polysorbate80;
Tea tree oil and polysorbate80;
Proportion is 0.95 to 1.07 oil and polysorbate80;
Oleum Anisi Stellati and polysorbate80;
Oleum Ricini and polysorbate80;
Oleum Caryophylli and polysorbate80;
Oleum Cinnamomi and polysorbate80;
Oleum Cinnamomi and polysorbate80;
Proportion is 0.90 to 0.95 oil and polysorbate80;
Almond oil and polysorbate80;
Semen Maydis oil and polysorbate80;
Oleum Arachidis hypogaeae semen and polysorbate80;
Oleum Gossypii semen and polysorbate80;
Safflower oil and polysorbate80;
Oleum maydis and polysorbate80;
Semen Lini oil and polysorbate80;
Oleum Brassicae campestris and polysorbate80;
Soybean oil and polysorbate80;
Olive oil and polysorbate80;
Caraway seed oil and polysorbate80;
Oil of rosemary and polysorbate80;
Oleum Arachidis hypogaeae semen and polysorbate80;
Oleum menthae and polysorbate80;
Oleum helianthi and polysorbate80;
Eucalyptus oil and polysorbate80;
Oleum sesami and polysorbate80;
Proportion is lower than 0.9 oil and polysorbate80;
Mineral oil and polysorbate80;
Fructus Coriandri oil and polysorbate80;
Essential lavender oil and polysorbate80;
Citronella oil and polysorbate80;
Oleum juniperi e baccarae and polysorbate80;
Fructus Citri Limoniae oil and polysorbate80;
Orange oil and polysorbate80;
Sage oil and polysorbate80;
Semen Myristicae oil and polysorbate80;
Tea tree oil and polysorbate80;
Proportion is 0.95 to 1.07 oil and polysorbate60;
Oleum Anisi Stellati and polysorbate60;
Oleum Ricini and polysorbate60;
Oleum Caryophylli and polysorbate60;
Oleum Cinnamomi and polysorbate60;
Oleum Cinnamomi and polysorbate60;
Proportion is 0.90 to 0.95 oil and polysorbate60;
Almond oil and polysorbate60;
Semen Maydis oil and polysorbate60;
Oleum Arachidis hypogaeae semen and polysorbate60;
Oleum Gossypii semen and polysorbate60;
Safflower oil and polysorbate60;
Oleum maydis and polysorbate60;
Semen Lini oil and polysorbate60;
Oleum Brassicae campestris and polysorbate60;
Soybean oil and polysorbate60;
Olive oil and polysorbate60;
Caraway seed oil and polysorbate60;
Oil of rosemary and polysorbate60;
Oleum Arachidis hypogaeae semen and polysorbate60;
Oleum menthae and polysorbate60;
Oleum helianthi and polysorbate60;
Eucalyptus oil and polysorbate60;
Oleum sesami and polysorbate60;
Proportion is lower than 0.9 oil and polysorbate60;
Mineral oil and polysorbate60;
Fructus Coriandri oil and polysorbate60;
Essential lavender oil and polysorbate60;
Citronella oil and polysorbate60;
Oleum juniperi e baccarae and polysorbate60;
Fructus Citri Limoniae oil and polysorbate60;
Orange oil and polysorbate60;
Sage oil and polysorbate60;
Semen Myristicae oil and polysorbate60;
Tea tree oil and polysorbate60;
Proportion is 0.95 to 1.07 oil and polysorbate40;
Oleum Anisi Stellati and polysorbate40;
Oleum Ricini and polysorbate40;
Oleum Caryophylli and polysorbate40;
Oleum Cinnamomi and polysorbate40;
Oleum Cinnamomi and polysorbate40;
Proportion is 0.90 to 0.95 oil and polysorbate40;
Almond oil and polysorbate40;
Semen Maydis oil and polysorbate40;
Oleum Arachidis hypogaeae semen and polysorbate40;
Oleum Gossypii semen and polysorbate40;
Safflower oil and polysorbate40;
Oleum maydis and polysorbate40;
Semen Lini oil and polysorbate40;
Oleum Brassicae campestris and polysorbate40;
Soybean oil and polysorbate40;
Olive oil and polysorbate40;
Caraway seed oil and polysorbate40;
Oil of rosemary and polysorbate40;
Oleum Arachidis hypogaeae semen and polysorbate40;
Oleum menthae and polysorbate40;
Oleum helianthi and polysorbate40;
Eucalyptus oil and polysorbate40;
Oleum sesami and polysorbate40;
Proportion is lower than 0.9 oil and polysorbate40;
Mineral oil and polysorbate40;
Fructus Coriandri oil and polysorbate40;
Essential lavender oil and polysorbate40;
Citronella oil and polysorbate40;
Oleum juniperi e baccarae and polysorbate40;
Fructus Citri Limoniae oil and polysorbate40;
Orange oil and polysorbate40;
Sage oil and polysorbate40;
Semen Myristicae oil and polysorbate40;
Tea tree oil and polysorbate40;
Proportion is 0.95 to 1.07 oil and polysorbate20;
Oleum Anisi Stellati and polysorbate20;
Oleum Ricini and polysorbate20;
Oleum Caryophylli and polysorbate20;
Oleum Cinnamomi and polysorbate20;
Oleum Cinnamomi and polysorbate20;
Proportion is 0.90 to 0.95 oil and polysorbate20;
Almond oil and polysorbate20;
Semen Maydis oil and polysorbate20;
Oleum Arachidis hypogaeae semen and polysorbate20;
Oleum Gossypii semen and polysorbate20;
Safflower oil and polysorbate20;
Oleum maydis and polysorbate20;
Semen Lini oil and polysorbate20;
Oleum Brassicae campestris and polysorbate20;
Soybean oil and polysorbate20;
Olive oil and polysorbate20;
Caraway seed oil and polysorbate20;
Oil of rosemary and polysorbate20;
Oleum Arachidis hypogaeae semen and polysorbate20;
Oleum menthae and polysorbate20;
Oleum helianthi and polysorbate20;
Eucalyptus oil and polysorbate20;
Oleum sesami and polysorbate20;
Proportion is lower than 0.9 oil and polysorbate20;
Mineral oil and polysorbate20;
Fructus Coriandri oil and polysorbate20;
Essential lavender oil and polysorbate20;
Citronella oil and polysorbate20;
Oleum juniperi e baccarae and polysorbate20;
Fructus Citri Limoniae oil and polysorbate20;
Orange oil and polysorbate20;
Sage oil and polysorbate20;
Semen Myristicae oil and polysorbate20;
Tea tree oil and polysorbate20;
Proportion is 0.95 to 1.07 oil and stearate surfactant;
Oleum Anisi Stellati and stearate surfactant;
Oleum Ricini and stearate surfactant;
Oleum Caryophylli and stearate surfactant;
Oleum Cinnamomi and stearate surfactant;
Oleum Cinnamomi and stearate surfactant;
Proportion is 0.90 to 0.95 oil and stearate surfactant;
Almond oil and stearate surfactant;
Semen Maydis oil and stearate surfactant;
Oleum Arachidis hypogaeae semen and stearate surfactant;
Oleum Gossypii semen and stearate surfactant;
Safflower oil and stearate surfactant;
Oleum maydis and stearate surfactant;
Semen Lini oil and stearate surfactant;
Oleum Brassicae campestris and stearate surfactant;
Soybean oil and stearate surfactant;
Olive oil and stearate surfactant;
Caraway seed oil and stearate surfactant;
Oil of rosemary and stearate surfactant;
Oleum Arachidis hypogaeae semen and stearate surfactant;
Oleum menthae and stearate surfactant;
Oleum helianthi and stearate surfactant;
Eucalyptus oil and stearate surfactant;
Oleum sesami and stearate surfactant;
Proportion is lower than 0.9 oil and stearate surfactant;
Mineral oil and stearate surfactant;
Fructus Coriandri oil and stearate surfactant;
Essential lavender oil and stearate surfactant;
Citronella oil and stearate surfactant;
Oleum juniperi e baccarae and stearate surfactant;
Fructus Citri Limoniae oil and stearate surfactant;
Orange oil and stearate surfactant;
Sage oil and stearate surfactant;
Semen Myristicae oil and stearate surfactant;
Tea tree oil and stearate surfactant;
Proportion is 0.95 to 1.07 oil and tristerin;
Oleum Anisi Stellati and tristerin;
Oleum Ricini and tristerin;
Oleum Caryophylli and tristerin;
Oleum Cinnamomi and tristerin;
Oleum Cinnamomi and tristerin;
Proportion is 0.90 to 0.95 oil and tristerin;
Almond oil and tristerin;
Semen Maydis oil and tristerin;
Oleum Arachidis hypogaeae semen and tristerin;
Oleum Gossypii semen and tristerin;
Safflower oil and tristerin;
Oleum maydis and tristerin;
Semen Lini oil and tristerin;
Oleum Brassicae campestris and tristerin;
Soybean oil and tristerin;
Olive oil and tristerin;
Caraway seed oil and tristerin;
Oil of rosemary and tristerin;
Oleum Arachidis hypogaeae semen and tristerin;
Oleum menthae and tristerin;
Oleum helianthi and tristerin;
Eucalyptus oil and tristerin;
Oleum sesami and tristerin;
Proportion is lower than 0.9 oil and tristerin;
Mineral oil and tristerin;
Fructus Coriandri oil and tristerin;
Essential lavender oil and tristerin;
Citronella oil and tristerin;
Oleum juniperi e baccarae and tristerin;
Fructus Citri Limoniae oil and tristerin;
Orange oil and tristerin;
Sage oil and tristerin;
Semen Myristicae oil and tristerin;
Tea tree oil and tristerin;
Proportion is 0.95 to 1.07 oil and isopropyl stearate;
Oleum Anisi Stellati and isopropyl stearate;
Oleum Ricini and isopropyl stearate;
Oleum Caryophylli and isopropyl stearate;
Oleum Cinnamomi and isopropyl stearate;
Oleum Cinnamomi and isopropyl stearate;
Proportion is 0.90 to 0.95 oil and isopropyl stearate;
Almond oil and isopropyl stearate;
Semen Maydis oil and isopropyl stearate;
Oleum Arachidis hypogaeae semen and isopropyl stearate;
Oleum Gossypii semen and isopropyl stearate;
Safflower oil and isopropyl stearate;
Oleum maydis and isopropyl stearate;
Semen Lini oil and isopropyl stearate;
Oleum Brassicae campestris and isopropyl stearate;
Soybean oil and isopropyl stearate;
Olive oil and isopropyl stearate;
Caraway seed oil and isopropyl stearate;
Oil of rosemary and isopropyl stearate;
Oleum Arachidis hypogaeae semen and isopropyl stearate;
Oleum menthae and isopropyl stearate;
Oleum helianthi and isopropyl stearate;
Eucalyptus oil and isopropyl stearate;
Oleum sesami and isopropyl stearate;
Proportion is lower than 0.9 oil and isopropyl stearate;
Mineral oil and isopropyl stearate;
Fructus Coriandri oil and isopropyl stearate;
Essential lavender oil and isopropyl stearate;
Citronella oil and isopropyl stearate;
Oleum juniperi e baccarae and isopropyl stearate;
Fructus Citri Limoniae oil and isopropyl stearate;
Orange oil and isopropyl stearate;
Sage oil and isopropyl stearate;
Semen Myristicae oil and isopropyl stearate;
Tea tree oil and isopropyl stearate;
Proportion is 0.95 to 1.07 oil and polyoxyl stearate;
Oleum Anisi Stellati and polyoxyl stearate;
Oleum Ricini and polyoxyl stearate;
Oleum Caryophylli and polyoxyl stearate;
Oleum Cinnamomi and polyoxyl stearate;
Oleum Cinnamomi and polyoxyl stearate;
Proportion is 0.90 to 0.95 oil and polyoxyl stearate;
Almond oil and polyoxyl stearate;
Semen Maydis oil and polyoxyl stearate;
Oleum Arachidis hypogaeae semen and polyoxyl stearate;
Oleum Gossypii semen and polyoxyl stearate;
Safflower oil and polyoxyl stearate;
Oleum maydis and polyoxyl stearate;
Semen Lini oil and polyoxyl stearate;
Oleum Brassicae campestris and polyoxyl stearate;
Soybean oil and polyoxyl stearate;
Olive oil and polyoxyl stearate;
Caraway seed oil and polyoxyl stearate;
Oil of rosemary and polyoxyl stearate;
Oleum Arachidis hypogaeae semen and polyoxyl stearate;
Oleum menthae and polyoxyl stearate;
Oleum helianthi and polyoxyl stearate;
Eucalyptus oil and polyoxyl stearate;
Oleum sesami and polyoxyl stearate;
Proportion is lower than 0.9 oil and polyoxyl stearate;
Mineral oil and polyoxyl stearate;
Fructus Coriandri oil and polyoxyl stearate;
Essential lavender oil and polyoxyl stearate;
Citronella oil and polyoxyl stearate;
Oleum juniperi e baccarae and polyoxyl stearate;
Fructus Citri Limoniae oil and polyoxyl stearate;
Orange oil and polyoxyl stearate;
Sage oil and polyoxyl stearate;
Semen Myristicae oil and polyoxyl stearate;
Tea tree oil and polyoxyl stearate;
Proportion is 0.95 to 1.07 oil and propylene glycol stearate;
Oleum Anisi Stellati and propylene glycol stearate;
Oleum Ricini and propylene glycol stearate;
Oleum Caryophylli and propylene glycol stearate;
Oleum Cinnamomi and propylene glycol stearate;
Oleum Cinnamomi and propylene glycol stearate;
Proportion is 0.90 to 0.95 oil and propylene glycol stearate;
Almond oil and propylene glycol stearate;
Semen Maydis oil and propylene glycol stearate;
Oleum Arachidis hypogaeae semen and propylene glycol stearate;
Oleum Gossypii semen and propylene glycol stearate;
Safflower oil and propylene glycol stearate;
Oleum maydis and propylene glycol stearate;
Semen Lini oil and propylene glycol stearate;
Oleum Brassicae campestris and propylene glycol stearate;
Soybean oil and propylene glycol stearate;
Olive oil and propylene glycol stearate;
Caraway seed oil and propylene glycol stearate;
Oil of rosemary and propylene glycol stearate;
Oleum Arachidis hypogaeae semen and propylene glycol stearate;
Oleum menthae and propylene glycol stearate;
Oleum helianthi and propylene glycol stearate;
Eucalyptus oil and propylene glycol stearate;
Oleum sesami and propylene glycol stearate;
Proportion is lower than 0.9 oil and propylene glycol stearate;
Mineral oil and propylene glycol stearate;
Fructus Coriandri oil and propylene glycol stearate;
Essential lavender oil and propylene glycol stearate;
Citronella oil and propylene glycol stearate;
Oleum juniperi e baccarae and propylene glycol stearate;
Fructus Citri Limoniae oil and propylene glycol stearate;
Orange oil and propylene glycol stearate;
Sage oil and propylene glycol stearate;
Semen Myristicae oil and propylene glycol stearate;
Tea tree oil and propylene glycol stearate;
Proportion is 0.95 to 1.07 oil and stearic acid sucrose ester;
Oleum Anisi Stellati and stearic acid sucrose ester;
Oleum Ricini and stearic acid sucrose ester;
Oleum Caryophylli and stearic acid sucrose ester;
Oleum Cinnamomi and stearic acid sucrose ester;
Oleum Cinnamomi and stearic acid sucrose ester;
Proportion is 0.90 to 0.95 oil and stearic acid sucrose ester;
Almond oil and stearic acid sucrose ester;
Semen Maydis oil and stearic acid sucrose ester;
Oleum Arachidis hypogaeae semen and stearic acid sucrose ester;
Oleum Gossypii semen and stearic acid sucrose ester;
Safflower oil and stearic acid sucrose ester;
Oleum maydis and stearic acid sucrose ester;
Semen Lini oil and stearic acid sucrose ester;
Oleum Brassicae campestris and stearic acid sucrose ester;
Soybean oil and stearic acid sucrose ester;
Olive oil and stearic acid sucrose ester;
Caraway seed oil and stearic acid sucrose ester;
Oil of rosemary and stearic acid sucrose ester;
Oleum Arachidis hypogaeae semen and stearic acid sucrose ester;
Oleum menthae and stearic acid sucrose ester;
Oleum helianthi and stearic acid sucrose ester;
Eucalyptus oil and stearic acid sucrose ester;
Oleum sesami and stearic acid sucrose ester;
Proportion is lower than 0.9 oil and stearic acid sucrose ester;
Mineral oil and stearic acid sucrose ester;
Fructus Coriandri oil and stearic acid sucrose ester;
Essential lavender oil and stearic acid sucrose ester;
Citronella oil and stearic acid sucrose ester;
Oleum juniperi e baccarae and stearic acid sucrose ester;
Fructus Citri Limoniae oil and stearic acid sucrose ester;
Orange oil and stearic acid sucrose ester;
Sage oil and stearic acid sucrose ester;
Semen Myristicae oil and stearic acid sucrose ester;
Tea tree oil and stearic acid sucrose ester;
Proportion is 0.95 to 1.07 oil and Polyethylene Glycol;
Oleum Anisi Stellati and Polyethylene Glycol;
Oleum Ricini and Polyethylene Glycol;
Oleum Caryophylli and Polyethylene Glycol;
Oleum Cinnamomi and Polyethylene Glycol;
Oleum Cinnamomi and Polyethylene Glycol;
Proportion is 0.90 to 0.95 oil and Polyethylene Glycol;
Almond oil and Polyethylene Glycol;
Semen Maydis oil and Polyethylene Glycol;
Oleum Arachidis hypogaeae semen and Polyethylene Glycol;
Oleum Gossypii semen and Polyethylene Glycol;
Safflower oil and Polyethylene Glycol;
Oleum maydis and Polyethylene Glycol;
Semen Lini oil and Polyethylene Glycol;
Oleum Brassicae campestris and Polyethylene Glycol;
Soybean oil and Polyethylene Glycol;
Olive oil and Polyethylene Glycol;
Caraway seed oil and Polyethylene Glycol;
Oil of rosemary and Polyethylene Glycol;
Oleum Arachidis hypogaeae semen and Polyethylene Glycol;
Oleum menthae and Polyethylene Glycol;
Oleum helianthi and Polyethylene Glycol;
Eucalyptus oil and Polyethylene Glycol;
Oleum sesami and Polyethylene Glycol;
Proportion is lower than 0.9 oil and Polyethylene Glycol;
Mineral oil and Polyethylene Glycol;
Fructus Coriandri oil and Polyethylene Glycol;
Essential lavender oil and Polyethylene Glycol;
Citronella oil and Polyethylene Glycol;
Oleum juniperi e baccarae and Polyethylene Glycol;
Fructus Citri Limoniae oil and Polyethylene Glycol;
Orange oil and Polyethylene Glycol;
Sage oil and Polyethylene Glycol;
Semen Myristicae oil and Polyethylene Glycol;
Tea tree oil and Polyethylene Glycol;
Proportion is 0.95 to 1.07 oil and poly(ethylene oxide);
Oleum Anisi Stellati and poly(ethylene oxide);
Oleum Ricini and poly(ethylene oxide);
Oleum Caryophylli and poly(ethylene oxide);
Oleum Cinnamomi and poly(ethylene oxide);
Oleum Cinnamomi and poly(ethylene oxide);
Proportion is 0.90 to 0.95 oil and poly(ethylene oxide);
Almond oil and poly(ethylene oxide);
Semen Maydis oil and poly(ethylene oxide);
Oleum Arachidis hypogaeae semen and poly(ethylene oxide);
Oleum Gossypii semen and poly(ethylene oxide);
Safflower oil and poly(ethylene oxide);
Oleum maydis and poly(ethylene oxide);
Semen Lini oil and poly(ethylene oxide);
Oleum Brassicae campestris and poly(ethylene oxide);
Soybean oil and poly(ethylene oxide);
Olive oil and poly(ethylene oxide);
Caraway seed oil and poly(ethylene oxide);
Oil of rosemary and poly(ethylene oxide);
Oleum Arachidis hypogaeae semen and poly(ethylene oxide);
Oleum menthae and poly(ethylene oxide);
Oleum helianthi and poly(ethylene oxide);
Eucalyptus oil and poly(ethylene oxide);
Oleum sesami and poly(ethylene oxide);
Proportion is lower than 0.9 oil and poly(ethylene oxide);
Mineral oil and poly(ethylene oxide);
Fructus Coriandri oil and poly(ethylene oxide);
Essential lavender oil and poly(ethylene oxide);
Citronella oil and poly(ethylene oxide);
Oleum juniperi e baccarae and poly(ethylene oxide);
Fructus Citri Limoniae oil and poly(ethylene oxide)
Orange oil and poly(ethylene oxide);
Sage oil and poly(ethylene oxide);
Semen Myristicae oil and poly(ethylene oxide);
Tea tree oil and poly(ethylene oxide);
Proportion is 0.95 to 1.07 oil and poly(propylene oxide);
Oleum Anisi Stellati and poly(propylene oxide);
Oleum Ricini and poly(propylene oxide);
Oleum Caryophylli and poly(propylene oxide);
Oleum Cinnamomi and poly(propylene oxide);
Oleum Cinnamomi and poly(propylene oxide);
Proportion is 0.90 to 0.95 oil and poly(propylene oxide);
Almond oil and poly(propylene oxide);
Semen Maydis oil and poly(propylene oxide);
Oleum Arachidis hypogaeae semen and poly(propylene oxide);
Oleum Gossypii semen and poly(propylene oxide);
Safflower oil and poly(propylene oxide);
Oleum maydis and poly(propylene oxide);
Semen Lini oil and poly(propylene oxide);
Oleum Brassicae campestris and poly(propylene oxide);
Soybean oil and poly(propylene oxide);
Olive oil and poly(propylene oxide);
Caraway seed oil and poly(propylene oxide);
Oil of rosemary and poly(propylene oxide);
Oleum Arachidis hypogaeae semen and poly(propylene oxide);
Oleum menthae and poly(propylene oxide);
Oleum helianthi and poly(propylene oxide);
Eucalyptus oil and poly(propylene oxide);
Oleum sesami and poly(propylene oxide);
Proportion is lower than 0.9 oil and poly(propylene oxide);
Mineral oil and poly(propylene oxide);
Fructus Coriandri oil and poly(propylene oxide);
Essential lavender oil and poly(propylene oxide);
Citronella oil and poly(propylene oxide);
Oleum juniperi e baccarae and poly(propylene oxide);
Fructus Citri Limoniae oil and poly(propylene oxide);
Orange oil and poly(propylene oxide);
Sage oil and poly(propylene oxide);
Semen Myristicae oil and poly(propylene oxide);
Tea tree oil and poly(propylene oxide);
Proportion is 0.95 to 1.07 oil and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Oleum Anisi Stellati and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Oleum Ricini and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Oleum Caryophylli and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Oleum Cinnamomi and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Oleum Cinnamomi and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Proportion is 0.90 to 0.95 oil and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Almond oil and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Semen Maydis oil and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Oleum Arachidis hypogaeae semen and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Oleum Gossypii semen and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Safflower oil and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Oleum maydis and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Semen Lini oil and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Oleum Brassicae campestris and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Soybean oil and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Olive oil and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Caraway seed oil and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Oil of rosemary and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Oleum Arachidis hypogaeae semen and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Oleum menthae and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Oleum helianthi and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Eucalyptus oil and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Oleum sesami and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Proportion is lower than 0.9 oil and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Mineral oil and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Fructus Coriandri oil and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Essential lavender oil and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Citronella oil and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Oleum juniperi e baccarae and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Fructus Citri Limoniae oil and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Orange oil and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Sage oil and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Semen Myristicae oil and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Tea tree oil and poly(ethylene oxide)-poly(propylene oxide) copolymer;
Proportion is 0.95 to 1.07 oil and alcohol ethoxylate;
Oleum Anisi Stellati and alcohol ethoxylate;
Oleum Ricini and alcohol ethoxylate;
Oleum Caryophylli and alcohol ethoxylate;
Oleum Cinnamomi and alcohol ethoxylate;
Oleum Cinnamomi and alcohol ethoxylate;
Proportion is 0.90 to 0.95 oil and alcohol ethoxylate;
Almond oil and alcohol ethoxylate;
Semen Maydis oil and alcohol ethoxylate;
Oleum Arachidis hypogaeae semen and alcohol ethoxylate;
Oleum Gossypii semen and alcohol ethoxylate;
Safflower oil and alcohol ethoxylate;
Oleum maydis and alcohol ethoxylate;
Semen Lini oil and alcohol ethoxylate;
Oleum Brassicae campestris and alcohol ethoxylate;
Soybean oil and alcohol ethoxylate;
Olive oil and alcohol ethoxylate;
Caraway seed oil and alcohol ethoxylate;
Oil of rosemary and alcohol ethoxylate;
Oleum Arachidis hypogaeae semen and alcohol ethoxylate;
Oleum menthae and alcohol ethoxylate;
Oleum helianthi and alcohol ethoxylate;
Eucalyptus oil and alcohol ethoxylate;
Oleum sesami and alcohol ethoxylate;
Proportion is lower than 0.9 oil and alcohol ethoxylate;
Mineral oil and alcohol ethoxylate;
Fructus Coriandri oil and alcohol ethoxylate;
Essential lavender oil and alcohol ethoxylate;
Citronella oil and alcohol ethoxylate;
Oleum juniperi e baccarae and alcohol ethoxylate;
Fructus Citri Limoniae oil and alcohol ethoxylate;
Orange oil and alcohol ethoxylate;
Sage oil and alcohol ethoxylate;
Semen Myristicae oil and alcohol ethoxylate;
Tea tree oil and alcohol ethoxylate;
Proportion is 0.95 to 1.07 oil and alkylphenol ethoxylate;
Oleum Anisi Stellati and alkylphenol ethoxylate;
Oleum Ricini and alkylphenol ethoxylate;
Oleum Caryophylli and alkylphenol ethoxylate;
Oleum Cinnamomi and alkylphenol ethoxylate;
Oleum Cinnamomi and alkylphenol ethoxylate;
Proportion is 0.90 to 0.95 oil and alkylphenol ethoxylate;
Almond oil and alkylphenol ethoxylate;
Semen Maydis oil and alkylphenol ethoxylate;
Oleum Arachidis hypogaeae semen and alkylphenol ethoxylate;
Oleum Gossypii semen and alkylphenol ethoxylate;
Safflower oil and alkylphenol ethoxylate;
Oleum maydis and alkylphenol ethoxylate;
Semen Lini oil and alkylphenol ethoxylate;
Oleum Brassicae campestris and alkylphenol ethoxylate;
Soybean oil and alkylphenol ethoxylate;
Olive oil and alkylphenol ethoxylate;
Caraway seed oil and alkylphenol ethoxylate;
Oil of rosemary and alkylphenol ethoxylate;
Oleum Arachidis hypogaeae semen and alkylphenol ethoxylate;
Oleum menthae and alkylphenol ethoxylate;
Oleum helianthi and alkylphenol ethoxylate;
Eucalyptus oil and alkylphenol ethoxylate;
Oleum sesami and alkylphenol ethoxylate;
Proportion is lower than 0.9 oil and alkylphenol ethoxylate;
Mineral oil and alkylphenol ethoxylate;
Fructus Coriandri oil and alkylphenol ethoxylate;
Essential lavender oil and alkylphenol ethoxylate;
Citronella oil and alkylphenol ethoxylate;
Oleum juniperi e baccarae and alkylphenol ethoxylate;
Fructus Citri Limoniae oil and alkylphenol ethoxylate;
Orange oil and alkylphenol ethoxylate;
Sage oil and alkylphenol ethoxylate;
Semen Myristicae oil and alkylphenol ethoxylate;
Tea tree oil and alkylphenol ethoxylate;
Proportion is 0.95 to 1.07 oil and alkyl polyglucoside;
Oleum Anisi Stellati and alkyl polyglucoside;
Oleum Ricini and alkyl polyglucoside;
Oleum Caryophylli and alkyl polyglucoside;
Oleum Cinnamomi and alkyl polyglucoside;
Oleum Cinnamomi and alkyl polyglucoside;
Proportion is 0.90 to 0.95 oil and alkyl polyglucoside;
Almond oil and alkyl polyglucoside;
Semen Maydis oil and alkyl polyglucoside;
Oleum Arachidis hypogaeae semen and alkyl polyglucoside;
Oleum Gossypii semen and alkyl polyglucoside;
Safflower oil and alkyl polyglucoside;
Oleum maydis and alkyl polyglucoside;
Semen Lini oil and alkyl polyglucoside;
Oleum Brassicae campestris and alkyl polyglucoside;
Soybean oil and alkyl polyglucoside;
Olive oil and alkyl polyglucoside;
Caraway seed oil and alkyl polyglucoside;
Oil of rosemary and alkyl polyglucoside;
Oleum Arachidis hypogaeae semen and alkyl polyglucoside;
Oleum menthae and alkyl polyglucoside;
Oleum helianthi and alkyl polyglucoside;
Eucalyptus oil and alkyl polyglucoside;
Oleum sesami and alkyl polyglucoside;
Proportion is lower than 0.9 oil and alkyl polyglucoside;
Mineral oil and alkyl polyglucoside;
Fructus Coriandri oil and alkyl polyglucoside;
Essential lavender oil and alkyl polyglucoside;
Citronella oil and alkyl polyglucoside;
Oleum juniperi e baccarae and alkyl polyglucoside;
Fructus Citri Limoniae oil and alkyl polyglucoside;
Orange oil and alkyl polyglucoside;
Sage oil and alkyl polyglucoside;
Semen Myristicae oil and alkyl polyglucoside;
Tea tree oil and alkyl polyglucoside;
Proportion is 0.95 to 1.07 oil and alkyl polyglucoside;
Oleum Anisi Stellati and alkyl polyglucoside;
Oleum Ricini and alkyl polyglucoside;
Oleum Caryophylli and alkyl polyglucoside;
Oleum Cinnamomi and alkyl polyglucoside;
Oleum Cinnamomi and alkyl polyglucoside;
Proportion is 0.90 to 0.95 oil and alkyl polyglucoside;
Almond oil and alkyl polyglucoside;
Semen Maydis oil and alkyl polyglucoside;
Oleum Arachidis hypogaeae semen and alkyl polyglucoside;
Oleum Gossypii semen and alkyl polyglucoside;
Safflower oil and alkyl polyglucoside;
Oleum maydis and alkyl polyglucoside;
Semen Lini oil and alkyl polyglucoside;
Oleum Brassicae campestris and alkyl polyglucoside;
Soybean oil and alkyl polyglucoside;
Olive oil and alkyl polyglucoside;
Caraway seed oil and alkyl polyglucoside;
Oil of rosemary and alkyl polyglucoside;
Oleum Arachidis hypogaeae semen and alkyl polyglucoside;
Oleum menthae and alkyl polyglucoside;
Oleum helianthi and alkyl polyglucoside;
Eucalyptus oil and alkyl polyglucoside;
Oleum sesami and alkyl polyglucoside;
Proportion is lower than 0.9 oil and alkyl polyglucoside;
Mineral oil and alkyl polyglucoside;
Fructus Coriandri oil and alkyl polyglucoside;
Essential lavender oil and alkyl polyglucoside;
Citronella oil and alkyl polyglucoside;
Oleum juniperi e baccarae and alkyl polyglucoside;
Fructus Citri Limoniae oil and alkyl polyglucoside;
Orange oil and alkyl polyglucoside;
Sage oil and alkyl polyglucoside;
Semen Myristicae oil and alkyl polyglucoside;
Tea tree oil and alkyl polyglucoside;
Proportion is 0.95 to 1.07 oil & fat alcohol;
Oleum Anisi Stellati and fatty alcohol;
Oleum Ricini and fatty alcohol;
Oleum Caryophylli and fatty alcohol;
Oleum Cinnamomi and fatty alcohol;
Oleum Cinnamomi and fatty alcohol;
Proportion is 0.90 to 0.95 oil & fat alcohol;
Almond oil and fatty alcohol;
Semen Maydis oil and fatty alcohol;
Oleum Arachidis hypogaeae semen and fatty alcohol;
Oleum Gossypii semen and fatty alcohol;
Safflower oil and fatty alcohol;
Oleum maydis and fatty alcohol;
Semen Lini oil and fatty alcohol;
Oleum Brassicae campestris and fatty alcohol;
Soybean oil and fatty alcohol;
Olive oil and fatty alcohol;
Caraway seed oil and fatty alcohol;
Oil of rosemary and fatty alcohol;
Oleum Arachidis hypogaeae semen and fatty alcohol;
Oleum menthae and fatty alcohol;
Oleum helianthi and fatty alcohol;
Eucalyptus oil and fatty alcohol;
Oleum sesami and fatty alcohol;
Proportion is lower than 0.9 oil & fat alcohol;
Mineral oil and fatty alcohol;
Fructus Coriandri oil and fatty alcohol;
Essential lavender oil and fatty alcohol;
Citronella oil and fatty alcohol;
Oleum juniperi e baccarae and fatty alcohol;
Fructus Citri Limoniae oil and fatty alcohol;
Orange oil and fatty alcohol;
Sage oil and fatty alcohol;
Semen Myristicae oil and fatty alcohol;
Tea tree oil and fatty alcohol;
Proportion is 0.95 to 1.07 oil and cellulose derivative;
Oleum Anisi Stellati and cellulose derivative;
Oleum Ricini and cellulose derivative;
Oleum Caryophylli and cellulose derivative;
Oleum Cinnamomi and cellulose derivative;
Oleum Cinnamomi and cellulose derivative;
Proportion is 0.90 to 0.95 oil and cellulose derivative;
Almond oil and cellulose derivative;
Semen Maydis oil and cellulose derivative;
Oleum Arachidis hypogaeae semen and cellulose derivative;
Oleum Gossypii semen and cellulose derivative;
Safflower oil and cellulose derivative;
Oleum maydis and cellulose derivative;
Semen Lini oil and cellulose derivative;
Oleum Brassicae campestris and cellulose derivative;
Soybean oil and cellulose derivative;
Olive oil and cellulose derivative;
Caraway seed oil and cellulose derivative;
Oil of rosemary and cellulose derivative;
Oleum Arachidis hypogaeae semen and cellulose derivative;
Oleum menthae and cellulose derivative;
Oleum helianthi and cellulose derivative;
Eucalyptus oil and cellulose derivative;
Oleum sesami and cellulose derivative;
Proportion is lower than 0.9 oil and cellulose derivative;
Mineral oil and cellulose derivative;
Sui oil and cellulose derivative;
Essential lavender oil and cellulose derivative;
Citronella oil and cellulose derivative;
Oleum juniperi e baccarae and cellulose derivative;
Fructus Citri Limoniae oil and cellulose derivative;
Orange oil and cellulose derivative;
Sage oil and cellulose derivative;
Semen Myristicae oil and cellulose derivative;
Tea tree oil and cellulose derivative;
Proportion is 0.95 to 1.07 oil and hydroxypropyl emthylcellulose;
Oleum Anisi Stellati and hydroxypropyl emthylcellulose;
Oleum Ricini and hydroxypropyl emthylcellulose;
Oleum Caryophylli and hydroxypropyl emthylcellulose;
Oleum Cinnamomi and hydroxypropyl emthylcellulose;
Oleum Cinnamomi and hydroxypropyl emthylcellulose;
Proportion is 0.90 to 0.95 oil and hydroxypropyl emthylcellulose;
Almond oil and hydroxypropyl emthylcellulose;
Semen Maydis oil and hydroxypropyl emthylcellulose;
Oleum Arachidis hypogaeae semen and hydroxypropyl emthylcellulose;
Oleum Gossypii semen and hydroxypropyl emthylcellulose;
Safflower oil and hydroxypropyl emthylcellulose;
Oleum maydis and hydroxypropyl emthylcellulose;
Semen Lini oil and hydroxypropyl emthylcellulose;
Oleum Brassicae campestris and hydroxypropyl emthylcellulose;
Soybean oil and hydroxypropyl emthylcellulose;
Olive oil and hydroxypropyl emthylcellulose;
Caraway seed oil and hydroxypropyl emthylcellulose;
Oil of rosemary and hydroxypropyl emthylcellulose;
Oleum Arachidis hypogaeae semen and hydroxypropyl emthylcellulose;
Oleum menthae and hydroxypropyl emthylcellulose;
Oleum helianthi and hydroxypropyl emthylcellulose;
Eucalyptus oil and hydroxypropyl emthylcellulose;
Oleum sesami and hydroxypropyl emthylcellulose;
Proportion is lower than 0.9 oil and hydroxypropyl emthylcellulose;
Mineral oil and hydroxypropyl emthylcellulose;
Fructus Coriandri oil and hydroxypropyl emthylcellulose;
Essential lavender oil and hydroxypropyl emthylcellulose;
Citronella oil and hydroxypropyl emthylcellulose;
Oleum juniperi e baccarae and hydroxypropyl emthylcellulose;
Fructus Citri Limoniae oil and hydroxypropyl emthylcellulose;
Orange oil and hydroxypropyl emthylcellulose;
Sage oil and hydroxypropyl emthylcellulose;
Semen Myristicae oil and hydroxypropyl emthylcellulose;
Tea tree oil and hydroxypropyl emthylcellulose;
Proportion is 0.95 to 1.07 oil and carboxymethyl cellulose;
Oleum Anisi Stellati and carboxymethyl cellulose;
Oleum Ricini and carboxymethyl cellulose;
Oleum Caryophylli and carboxymethyl cellulose;
Oleum Cinnamomi and carboxymethyl cellulose;
Oleum Cinnamomi and carboxymethyl cellulose;
Proportion is 0.90 to 0.95 oil and carboxymethyl cellulose;
Almond oil and carboxymethyl cellulose;
Semen Maydis oil and carboxymethyl cellulose;
Oleum Arachidis hypogaeae semen and carboxymethyl cellulose;
Oleum Gossypii semen and carboxymethyl cellulose;
Safflower oil and carboxymethyl cellulose;
Oleum maydis and carboxymethyl cellulose;
Semen Lini oil and carboxymethyl cellulose;
Oleum Brassicae campestris and carboxymethyl cellulose;
Soybean oil and carboxymethyl cellulose;
Olive oil and carboxymethyl cellulose;
Caraway seed oil and carboxymethyl cellulose;
Oil of rosemary and carboxymethyl cellulose;
Oleum Arachidis hypogaeae semen and carboxymethyl cellulose;
Oleum menthae and carboxymethyl cellulose;
Oleum helianthi and carboxymethyl cellulose;
Eucalyptus oil and carboxymethyl cellulose;
Oleum sesami and carboxymethyl cellulose;
Proportion is lower than 0.9 oil and carboxymethyl cellulose;
Mineral oil and carboxymethyl cellulose;
Fructus Coriandri oil and carboxymethyl cellulose;
Essential lavender oil and carboxymethyl cellulose;
Citronella oil and carboxymethyl cellulose;
Oleum juniperi e baccarae and carboxymethyl cellulose;
Fructus Citri Limoniae oil and carboxymethyl cellulose;
Orange oil and carboxymethyl cellulose;
Sage oil and carboxymethyl cellulose;
Semen Myristicae oil and carboxymethyl cellulose;
Tea tree oil and carboxymethyl cellulose;
Proportion is 0.95 to 1.07 oil and polyacrylic acid;
Oleum Anisi Stellati and polyacrylic acid;
Oleum Ricini and polyacrylic acid;
Oleum Caryophylli and polyacrylic acid;
Oleum Cinnamomi and polyacrylic acid;
Oleum Cinnamomi and polyacrylic acid;
Proportion is 0.90 to 0.95 oil and polyacrylic acid;
Almond oil and polyacrylic acid;
Semen Maydis oil and polyacrylic acid;
Oleum Arachidis hypogaeae semen and polyacrylic acid;
Oleum Gossypii semen and polyacrylic acid;
Safflower oil and polyacrylic acid;
Oleum maydis and polyacrylic acid;
Semen Lini oil and polyacrylic acid;
Oleum Brassicae campestris and polyacrylic acid;
Soybean oil and polyacrylic acid;
Olive oil and polyacrylic acid;
Caraway seed oil and polyacrylic acid;
Oil of rosemary and polyacrylic acid;
Oleum Arachidis hypogaeae semen and polyacrylic acid;
Oleum menthae and polyacrylic acid;
Oleum helianthi and polyacrylic acid;
Eucalyptus oil and polyacrylic acid;
Oleum sesami and polyacrylic acid;
Proportion is lower than 0.9 oil and polyacrylic acid;
Mineral oil and polyacrylic acid;
Fructus Coriandri oil and polyacrylic acid;
Essential lavender oil and polyacrylic acid;
Citronella oil and polyacrylic acid;
Oleum juniperi e baccarae and polyacrylic acid;
Fructus Citri Limoniae oil and polyacrylic acid;
Orange oil and polyacrylic acid;
Sage oil and polyacrylic acid;
Semen Myristicae oil and polyacrylic acid;
Tea tree oil and polyacrylic acid;
Proportion is 0.95 to 1.07 oil and carbomer;
Oleum Anisi Stellati and carbomer;
Oleum Ricini and carbomer;
Oleum Caryophylli and carbomer;
Oleum Cinnamomi and carbomer;
Oleum Cinnamomi and carbomer;
Proportion is 0.90 to 0.95 oil and carbomer;
Almond oil and carbomer;
Semen Maydis oil and carbomer;
Oleum Arachidis hypogaeae semen and carbomer;
Oleum Gossypii semen and carbomer;
Safflower oil and carbomer;
Oleum maydis and carbomer;
Semen Lini oil and carbomer;
Oleum Brassicae campestris and carbomer;
Soybean oil and carbomer;
Olive oil and carbomer;
Caraway seed oil and carbomer;
Oil of rosemary and carbomer;
Oleum Arachidis hypogaeae semen and carbomer;
Oleum menthae and carbomer;
Oleum helianthi and carbomer;
Eucalyptus oil and carbomer;
Oleum sesami and carbomer;
Proportion is lower than 0.9 oil and carbomer;
Mineral oil and carbomer;
Fructus Coriandri oil and carbomer;
Essential lavender oil and carbomer;
Citronella oil and carbomer;
Oleum juniperi e baccarae and carbomer;
Fructus Citri Limoniae oil and carbomer;
Orange oil and carbomer;
Sage oil and carbomer;
Semen Myristicae oil and carbomer;
Tea tree oil and carbomer;
Proportion is 0.95 to 1.07 oil and phospholipid;
Oleum Anisi Stellati and phospholipid;
Oleum Ricini and phospholipid;
Oleum Caryophylli and phospholipid;
Oleum Cinnamomi and phospholipid;
Oleum Cinnamomi and phospholipid;
Proportion is 0.90 to 0.95 oil and phospholipid;
Almond oil and phospholipid;
Semen Maydis oil and phospholipid;
Oleum Arachidis hypogaeae semen and phospholipid;
Oleum Gossypii semen and phospholipid;
Safflower oil and phospholipid;
Oleum maydis and phospholipid;
Semen Lini oil and phospholipid;
Oleum Brassicae campestris and phospholipid;
Soybean oil and phospholipid;
Olive oil and phospholipid;
Caraway seed oil and phospholipid;
Oil of rosemary and phospholipid;
Oleum Arachidis hypogaeae semen and phospholipid;
Oleum menthae and phospholipid;
Oleum helianthi and phospholipid;
Eucalyptus oil and phospholipid;
Oleum sesami and phospholipid;
Proportion is lower than 0.9 oil and phospholipid;
Mineral oil and phospholipid;
Fructus Coriandri oil and phospholipid;
Essential lavender oil and phospholipid;
Citronella oil and phospholipid;
Oleum juniperi e baccarae and phospholipid;
Fructus Citri Limoniae oil and phospholipid;
Orange oil and phospholipid;
Sage oil and phospholipid;
Semen Myristicae oil and phospholipid;
Tea tree oil and phospholipid;
Proportion is 0.95 to 1.07 oil and phosphatidylcholine;
Oleum Anisi Stellati and phosphatidylcholine;
Oleum Ricini and phosphatidylcholine;
Oleum Caryophylli and phosphatidylcholine;
Oleum Cinnamomi and phosphatidylcholine;
Oleum Cinnamomi and phosphatidylcholine;
Proportion is 0.90 to 0.95 oil and phosphatidylcholine;
Almond oil and phosphatidylcholine;
Semen Maydis oil and phosphatidylcholine;
Oleum Arachidis hypogaeae semen and phosphatidylcholine;
Oleum Gossypii semen and phosphatidylcholine;
Safflower oil and phosphatidylcholine;
Oleum maydis and phosphatidylcholine;
Semen Lini oil and phosphatidylcholine;
Oleum Brassicae campestris and phosphatidylcholine;
Soybean oil and phosphatidylcholine;
Olive oil and phosphatidylcholine;
Caraway seed oil and phosphatidylcholine;
Oil of rosemary and phosphatidylcholine;
Oleum Arachidis hypogaeae semen and phosphatidylcholine;
Oleum menthae and phosphatidylcholine;
Oleum helianthi and phosphatidylcholine;
Eucalyptus oil and phosphatidylcholine;
Oleum sesami and phosphatidylcholine;
Proportion is lower than 0.9 oil and phosphatidylcholine;
Mineral oil and phosphatidylcholine;
Fructus Coriandri oil and phosphatidylcholine;
Essential lavender oil and phosphatidylcholine;
Citronella oil and phosphatidylcholine;
Oleum juniperi e baccarae and phosphatidylcholine;
Fructus Citri Limoniae oil and phosphatidylcholine;
Orange oil and phosphatidylcholine;
Sage oil and phosphatidylcholine;
Semen Myristicae oil and phosphatidylcholine;
Tea tree oil and phosphatidylcholine;
Proportion is 0.95 to 1.07 oil and Phosphatidylserine;
Oleum Anisi Stellati and Phosphatidylserine;
Oleum Ricini and Phosphatidylserine;
Oleum Caryophylli and Phosphatidylserine;
Oleum Cinnamomi and Phosphatidylserine;
Oleum Cinnamomi and Phosphatidylserine;
Proportion is 0.90 to 0.95 oil and Phosphatidylserine;
Almond oil and Phosphatidylserine;
Semen Maydis oil and Phosphatidylserine;
Oleum Arachidis hypogaeae semen and Phosphatidylserine;
Oleum Gossypii semen and Phosphatidylserine;
Safflower oil and Phosphatidylserine;
Oleum maydis and Phosphatidylserine;
Semen Lini oil and Phosphatidylserine;
Oleum Brassicae campestris and Phosphatidylserine;
Soybean oil and Phosphatidylserine;
Olive oil and Phosphatidylserine;
Caraway seed oil and Phosphatidylserine;
Oil of rosemary and Phosphatidylserine;
Oleum Arachidis hypogaeae semen and Phosphatidylserine;
Oleum menthae and Phosphatidylserine;
Oleum helianthi and Phosphatidylserine;
Eucalyptus oil and Phosphatidylserine;
Oleum sesami and Phosphatidylserine;
Proportion is lower than 0.9 oil and Phosphatidylserine;
Mineral oil and Phosphatidylserine;
Fructus Coriandri oil and Phosphatidylserine;
Essential lavender oil and Phosphatidylserine;
Citronella oil and Phosphatidylserine;
Oleum juniperi e baccarae and Phosphatidylserine;
Fructus Citri Limoniae oil and Phosphatidylserine;
Orange oil and Phosphatidylserine;
Sage oil and Phosphatidylserine;
Semen Myristicae oil and Phosphatidylserine; And
Tea tree oil and Phosphatidylserine.
In one embodiment, the present invention can with compositions be self emulsifying, it only needs gentle agitation or does not need to stir just can to form fine O/w emulsion when being exposed to aqueous medium.The character of self emulsifying can be used by conc forms this type of preparation, for example, with the form of soft gelatin or viscosity paste.In addition, can be by the preconcentrate of self emulsifying be combined and prepares emulsion with aqueous medium.
Disclosed self emulsifying system comprises such system before this, wherein active component (as ciclosporin component) is combined with the mixture of following material: (i) medium chain triglyceride and non-ionic surface active agent, (ii) vegetable oil and partial glyceride, as the glyceride of Pegylation or medium chain monoglyceride and diglyceride, or (iii) vegetable oil and non-ionic surface active agent, as polysorbate80 or PEG-25 triolein.
In some self-emulsifiable preparation, " microemulsion preconcentrate " of ciclosporin component is by combining ciclosporin component to form with following material: (I) aqueous favoring, (II) lipophilic phase and (III) surfactant and optional thickening agent, antioxidant or other excipient.The example of such composition has disclosed in the people's such as Hauer United States Patent (USP) 5,342,625, and the disclosure of this patent is incorporated to herein with way of reference integral body.
In addition, suitable compositions can comprise the activating agent (such as ciclosporin component) together with hydrophilic solvent phase and one or more surfactants, but not containing lipophilic solvent.Good pharmacokinetic property can be stablized, be easy to prepare and have to this type of preparation containing ciclosporin component.
Unless elsewhere separately indicates herein, otherwise by compositions local application of the present invention.Yet other mode of administration are also possible, such as systemic administration, as dosage forms for oral administration capsule or suspension, intramuscular, intraperitoneal, subcutaneous and intra-articular injection or infusion are containing the compositions of ciclosporin component.Local application comprises ointment, drop, solution, paint (lacquer) (painted fingernail polishing agent or the paint that comprises independent antifungal), suspension or the emulsion containing ciclosporin component that can use applicator system well known in the art to use.Be intended to can directly prepare for locally applying to the topical formulations of one or more affected tissue regions, or by the concentrate containing ciclosporin component is combined and prepared with diluent (as aqueous diluent).This type of topical formulations can comprise other excipient where necessary, for example to change the concordance of the absorbance of ciclosporin component.
In preparation the present invention, can use compositions time, each component can be mixed in any order, stirs simultaneously or slightly shakes to guarantee to mix completely.
As required, can within the sufficient time, give the compositions of the present invention of sufficient quantity, thereby the required therapeutic effect that improves fingernail health is provided.Compositions of the present invention can be used with other treatment agent (such as the antifungal of dosage forms for oral administration) simultaneously.Concrete treatment effective dose level can be depending on some factors, comprises the order of severity of concrete disease to be treated, disease, the activity of specific ciclosporin component used, concrete compositions, time of application and method, treatment persistent period and other factors of knowing at field of medicaments containing ciclosporin component used.
Following non-limiting example illustrates some aspect of the present invention.
embodiment 1
Be studied to compare Ciclosporin A and emulsion BID.
● 2 fingernails of suffering from onychorrhexis syndrome (BNS)
● 2 " normally " fingernails
● one of a treatment or not
● N=24 (each treatment group 12 people)
● monthly follow up a case by regular visits to for 6 times
● 1 °-seriousness doctor comprehensive assessment (PGA)
● 2 °-a plurality of less important metric and photo
2 ° of assessments
The growth of-unguish
-doctor improves grade (PGIA)
-fragility/fracture (BNS)
-stratiform horizontal split-onycholysis
-protuberance
-longitudinal splitting
-thickness
-texture/smoothness
-gloss
Result and the satisfaction of-patient report
inclusive criteria
Must there is the onychorrhexis based on following aspect:
-on target fingernail, there are at least two kinds of S&Ss of onychorrhexis
-on each target fingernail, there is serious sign (one or more)
(i) asperities first (rough surface)
(ii) stratiform onycholysis (horizontal slice/peeling off)
(iii) longitudinal cracking of distal side edge or division (crude)
research treatment application
● at horny layer edge, then on nail plate, smear bottle
● make its evaporation drying
● a bottle is in the morning, and a bottle is in the afternoon
● do not carry out manicure the last week following up a case by regular visits to.
Confirmed that whole body is with improving the psoriatic S&S of fingernail with local with ciclosporin (by its T cytostatics, immunomodulator and antiinflammatory action).
Scope of the present invention should not be limited to disclosed specific embodiments in an embodiment, and these embodiments are intended to as the illustrating of several aspects of the present invention, and any embodiment being equal in function all within the scope of the invention.In fact, except shown and described herein, various modifications of the present invention will be become apparent for those skilled in the relevant art those, and be intended to fall within the scope of appended claims.
No matter the every a list of references of listing is herein that granted patent, patent application or magazine/scientific publications are all whole is incorporated to for all objects with way of reference.

Claims (15)

1. for promoting a compositions for the fingernail health of human patients, described compositions comprises immunomodulator, the form that wherein said compositions is O/w emulsion, and the local fingernail that is applied to described patient.
2. compositions according to claim 1, wherein said immunomodulator is ciclosporin.
3. compositions according to claim 1, also comprises antiinflammatory.
4. compositions according to claim 3, wherein said antiinflammatory is ketorolac.
5. compositions according to claim 1, wherein said emulsion comprises Oleum Ricini and surfactant.
6. compositions according to claim 1, wherein said emulsion comprises at least one component that is selected from glycerol, polysorbate80 and carbomer.
7. compositions according to claim 1, the polysorbate80 that wherein said compositions comprises 0.5%-1.5%w/w, the glycerol of 0.5%-1.5%w/w, the Oleum Ricini of 0.5%-1.5%w/w, the carbomer934 of 0.05%-0.1%w/w and mannitol.
8. compositions according to claim 1, wherein said compositions applies at least one times for one day.
9. compositions according to claim 1, it can be used for treating onychorrhexis syndrome.
10. compositions according to claim 1, it can be used for promoting nail growth.
11. compositionss according to claim 1, it can be used for treatment and is selected from following fingernail obstacle: fingernail psoriasis, psoriasis onychodystrophy, onychitis, curved first disease, onychoatrophy, ingrowing nail, Onychodystrophy, onychogryphosis, onycholysis, onychomadesis, onychauxis, tinea unguium, onychorrhexis, tinea unguium, onychophosis, onychoptosis, paronychia, pseudomonas infection, pterygium and pterygium inversum unguis, spoon nail, hematoma under nail or other wounds to fingernail, folic acid deficiency, leukonychia, refer to chatelain's syndrome, melanonychia, hypoproteinosis, onychorrhexis and first are peeled off, the fingernail of methyl methacrylate damage, vitamin C deficiency, avitaminosis, first tinea alba, the first relevant to lichen planus is thin soft, Raynaud disease, relevant to rheumatoid arthritis bleeds, Beau lines, poisoning relevant Michaelis line to some type.
12. compositionss according to claim 1, wherein said grease separation is from Oleum Anisi Stellati; Oleum Ricini; Oleum Caryophylli; Oleum Cinnamomi; Oleum Cinnamomi; The oil of proportion between 0.90 and 0.95; Almond oil; Semen Maydis oil; Oleum Arachidis hypogaeae semen; Oleum Gossypii semen; Safflower oil; Oleum maydis; Semen Lini oil; Oleum Brassicae campestris; Soybean oil; Olive oil; Caraway seed oil; Oil of rosemary; Oleum Arachidis hypogaeae semen; Oleum menthae; Oleum helianthi; Eucalyptus oil; Oleum sesami; The oil that proportion is less than 0.9; Mineral oil; Fructus Coriandri oil; Oleum lavandula angustifolia; Citronella oil; Oleum juniperi e baccarae; Fructus Citri Limoniae oil; Orange oil; Sage oil; Semen Myristicae oil; With tea tree oil or its mixture.
13. compositionss according to claim 1, wherein said O/w emulsion also comprises and is selected from following surfactant: polysorbate80, carboxylation and ethoxylated alcohol, amine oxide, block polymer, the fatty acid that comprises carboxylic fatty acids, ethoxylated alkylphenol, ethoxylated fat ester, glyceride, lanoline radical derivative, lignin derivative, methyl ester, monoglyceride and triglyceride, Polyethylene Glycol, polymeric surfactant, propoxylation and ethoxylated fatty acid, alcohol, or alkyl phenol, protein-based surfactant, sucrose and glucose ester and derivant thereof or mixture.
14. compositionss according to claim 1, wherein said oil exists to be selected from following concentration: 1.25%w/v, 0.01%-w/v – 10.0%w/v, 0.1%w/v – 5.0%w/v, 0.1%w/v – 4.0%w/v, 0.1%w/v – 3.0%w/v, 0.1%w/v – 2.0%w/v, 0.1%w/v – 1.0%w/v, 0.1%w/v – 0.9%w/v, 0.1%w/v – 0.8%w/v, 0.1%w/v – 0.8%w/v, 0.1%w/v – 0.7%w/v, 0.1%w/v – 0.6%w/v, 0.1%w/v – 0.5%w/v, 0.1%w/v – 0.4%w/v, 0.1%w/v – 0.3%w/v, 0.1%w/v – 0.2%w/v, 0.09%-0.1%w/v, 0.08%-0.1%w/v, 0.07%-0.1%w/v, 0.06%-0.1%w/v, 0.05%-0.1%w/v, 0.04%-0.1%w/v, 0.03%-0.1%w/v, 0.02%-0.1%w/v, 0.01%-0.1%w/v, 0.01 – 0.09%, 0.01 – 0.08%, 0.01 – 0.07%w/v, 0.01-0.06%w/v, 0.01 – 0.05%w/v, 0.01 – 0.04%w/v, 0.01 – 0.03%w/v, 0.01-0.02%w/v, 0.01 – 0.0125%w/v and 0.05%w/v – 5.0%w/v.
15. compositionss according to claim 1, wherein said surfactant exists to be selected from following concentration: 1.0%w/v, 0.01%-w/v – 10.0%w/v, 0.1%w/v – 5.0%w/v, 0.1%w/v – 4.0%w/v, 0.1%w/v – 3.0%w/v, 0.1%w/v – 2.0%w/v, 0.1%w/v – 1.0%w/v, 0.1%w/v – 0.9%w/v, 0.1%w/v – 0.8%w/v, 0.1%w/v – 0.7%w/v, 0.1%w/v – 0.6%w/v, 0.1%w/v – 0.5%w/v, 0.1%w/v – 0.4%w/v, 0.1%w/v – 0.3%w/v, 0.1%w/v – 0.2%w/v, 0.09%-0.1%w/v, 0.08%-0.1%w/v, 0.07%-0.1%w/v, 0.06%-0.1%w/v, 0.05%-0.1%w/v, 0.04%-0.1%w/v, 0.03%-0.1%w/v, 0.02%-0.1%w/v, 0.01%-0.1%w/v, 0.01 – 0.09%, 0.01 – 0.08%, 0.01 – 0.07%w/v, 0.01-0.06%w/v, 0.01 – 0.05%w/v, 0.01 – 0.04%w/v, 0.01 – 0.03%w/v, 0.01-0.02%w/v and 0.01 – 0.0125%w/v.
CN201280059691.1A 2011-10-05 2012-10-01 Compositions for enhancing nail health Pending CN103987370A (en)

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US9914755B2 (en) 2015-01-08 2018-03-13 Allergan, Inc. Cyclosporin derivatives wherein the MeBmt sidechain has been cyclized

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SE445174B (en) 1978-03-07 1986-06-09 Sandoz Ag PHARMACEUTICAL COMPOSITION CONTAINING A CYCLOSPORIN AND A HEALING SUBSTANCE
US5342625A (en) 1988-09-16 1994-08-30 Sandoz Ltd. Pharmaceutical compositions comprising cyclosporins
US5474979A (en) 1994-05-17 1995-12-12 Allergan, Inc. Nonirritating emulsions for sensitive tissue
IL144975A0 (en) 1999-02-26 2002-06-30 Univ British Columbia A composition containing an antisense oligonucleotide
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