CN103980343A - Multi-functional extracting, filtering and drying machine for albumen powder and applications thereof - Google Patents
Multi-functional extracting, filtering and drying machine for albumen powder and applications thereof Download PDFInfo
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- CN103980343A CN103980343A CN201410225698.7A CN201410225698A CN103980343A CN 103980343 A CN103980343 A CN 103980343A CN 201410225698 A CN201410225698 A CN 201410225698A CN 103980343 A CN103980343 A CN 103980343A
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Abstract
The invention discloses a multifunctional washing, filtering and drying machine and applications thereof. The machine comprises a tank, a stirring device, a filtering device, a clamp locking device, a discharge device and a basket filter, wherein the filtering device is arranged at the lower end part of the tank and closes a bottom opening of the tank, the clamp locking device is arranged at the lower end of the tank, the discharge device is fixed on the lower side face of the tank by welding, the stirring device is arranged in the central axis of the tank, the upper part of the stirring device is connected with an output shaft of a speed reducer at the top of the tank, and the basket filter is connected with a vacuumizing port at the top of the tank through an inlet of the basket filter, and connected with a vacuum system through an outlet. The total nitrogen of albumen powder produced by using the multifunctional washing, filtering and drying machine disclosed by the invention reaches over 120 mg/g. A production method is easy to control, and the machine is stable in quality and easy to store, and facilitates the implementation of a hydrolysis process.
Description
Technical field
The invention belongs to medicine mechanical equipment technical field, relate to the multi-functional extraction filtering drying machine of a kind of protein powder and application thereof.
Background technology
Cerebrolysin Vial class medicine occupies critical role at medical field, China was from external a large amount of these medicines of import in recent years, had more significant curative effect aspect the disease such as dysfunction, cerebral concussion sequela that functional disorder, apoplexy, cerebral infarction, encephalatrophy, brain memory obstacle and the cerebral trauma causing causes in the compensatory deficiency of the treatment cerebrovascular.At present, the Cerebrolysin Vial of being produced by Austrian Ebewe pharmaceutical factory has clinical application widely, produces Cerebrolysin Vial technique have no report about it.Based on this, Chinese scholars has been carried out a large amount of research of Cerebrolysin Vial.
" process for preparing injection liquid of brain protein hydrolyzate " that Chinese invention patent Granted publication CN1356141 provides and Granted publication CN1562339 " preparation method of pharmaceutics of hydrolysate of brain protein " will directly carry out corresponding hydrolysis process after fresh food frozen pig brain homogenate; " a kind of production system of protein powder " that Chinese utility model patent Granted publication CN202450012U provides discloses a kind of production system of protein powder, comprise successively feeding unit, drying installation, filtration unit, packing plant, described feeding unit comprises the high-pressure pump for delivery of albumen feed liquid; " a kind of metaprotein powder and the Cerebrolysin Vial that adopts this protein powder to prepare " that Chinese invention patent Granted publication CN102718857A provides discloses for the first time the total nitrogen index of control protein powder and carried out the preparation of Cerebrolysin Vial, and the pertinent literature that utilizes relevant device to produce brain protein powder aspect there is not yet report.
Summary of the invention
This equipment institute production of albumen powder is Cerebrolysin Vial intermediate.According to existing technique, utilize the method system of this multi-functional washing filtering drying machine production of albumen powder that fresh pig brain is become to thickness pulpous state pig brain through cleaning, pulverizing, homogenate aftertreatment, make brain protein powder through organic solvent degreasing again, by the protein powder making for hydrolysis process, more than the protein powder total nitrogen of producing reaches 120mg/g.Made protein powder is easy to control, and steady quality is convenient to preserve, and is convenient to the carrying out of hydrolysis process.
The invention discloses for achieving the above object following technology contents:
The multi-functional extraction filtering drying machine of a kind of protein powder, is characterized in that it comprises tank body 26, whipping appts 10, filtration unit 2, locked clip device device 3, drawing mechanism 5, basket filter 4; Filtration unit 2 is arranged on the bottom of tank body 26 and seals the bottom opening of this tank body, locked clip device device 3 is arranged on tank body 26 lower ends and is used for locking filtration unit 2, drawing mechanism 5 is fixed in tank body 26 downsides by welding, whipping appts 10 is on tank body 26 central axis, its top is connected with tank body 26 top step-down gear 37 output shafts, basket filter 4 is connected with tank body 26 top vacuum orifices 23 by import 46, is connected with vacuum system by exporting 47;
Wherein said tank body 26 is fixed by supporting leg 1, inside has tank chamber 50 and lower ending opening, tank wall has chuck 27, chuck top one side is furnished with one for the heating and cooling media outlet 14 by drawing heating and cooling medium in chuck, is furnished with a heating and cooling medium import 13 communicating with chuck in chuck bottom one side, wherein: heating and cooling media outlet 14 and the homonymy of heating and cooling medium import 13 at tank body 26;
57 upper ends, filtration unit 2 main part chassis are provided with the filter plate 56 for fixing filtering table 55 use, and filtering table 55 is made up of some sintering filter screens, and 57 lower ends, chassis are provided with chuck import and export 15, filtrate outlet 11, and filtration unit 2 is controlled lifting by hanging oil gear 8;
The coated layer of metal corrugated tube 36 of whipping appts 10 main part stir shaft 34, the two ends of metallic bellows 36 are connected with agitating vane 35 with mechanical seal 54 respectively, whipping appts 10 bottoms are connected with S type+rake Double-layer stirring paddle leaf, by the lifting of stir shaft hoist cylinder device 9 action control whipping apptss 10;
Locked clip device device 3 is made up of the ring-shaped clip 38, the rotation oil gear 7 that are provided with internal tooth;
Drawing mechanism 5 comprises the discharging cylindrical shell 39 that is connected to discharge port 40 places, and described discharging cylindrical shell 39 lower ends are provided with drawing mechanism outlet 18, and side is provided with drawing mechanism internal washing mouth 19, is inside provided with the discharge door 41 that discharge port 40 can be sealed;
Basket filter 4 comprises the basket filter chuck 48 of basket filter outer wall, basket filter Butterworth Hatch-nitrogen back blow port 22 at top, inner filtering net 58; Chuck top one side is furnished with one for the heating and cooling media outlet 17 by drawing heating and cooling medium in chuck, is furnished with a heating and cooling medium import 16 communicating with chuck in chuck bottom one side, wherein: heating and cooling media outlet 17 is angular dependence on basket filter 4 with the import 16 of heating and cooling medium.
Tank body 26 of the present invention mainly comprises top hand hole 28, material inlet 20,49, with the visor 12 of wiper, look socket 29, vacuum orifice 23, corrugated tube Butterworth Hatch 24, press filtration mouth 21, pressure transmitter mouth 30, temperature sensor mouth 31, refluxing opening 32, tank body Butterworth Hatch 33, drain 25.
The sintering filter screen that has six layers of 316L Stainless Steel Wire braiding in chassis 57 of the present invention, filtering accuracy is 10～15 μ m; The filtering accuracy of described basket filter 4 is 10～15 μ m.
The piston rod 43 that the discharge door 41 of drawing mechanism 5 of the present invention is connected with out-feed liquid pressure device 42 is connected, described piston rod 43 is coated with metallic bellows 44, the two ends of described metallic bellows 44 are connected with discharge door 41 with discharging cylindrical shell 39 respectively, the opening travel of discharge door 41 is completed by out-feed liquid pressure device 42, this discharging cylindrical shell 39 can be opened at rear end root, be beneficial to the discharge of leftover materials, in the time opening, need to unclamp the star grip knob 45 on front end shell ring 52 flanges, then discharging cylinder back-end shell ring 51 be opened along 90 degree.
Agitating vane 35 of the present invention be 2 leaves have can scraping filter cake scraper, there is the structure of extending filter cake plane blade bottom surface, stir and can wash when forward and the stirring and drying of the stirring of the discharge of material, material, filter cake, when reversion, can extend.
The present invention further discloses the production method that adopts the multi-functional extraction filtering drying machine of protein powder to extract protein powder in animal tissues, it is characterized in that being undertaken by following step:
(1) material loading: organic solvent is delivered to the process in multi-functional washing filtering drying machine tank with nitrogen, thickness pulpous state biological tissue material is drawn to the process in multi-functional washing filtering drying machine by nitrogen force feed or vacuum; By material inlet, aequum acetone is delivered in multi-functional washing filtering drying machine tank chamber with nitrogen; Aequum thickness pulpous state pig brain is drawn in multi-functional washing filtering drying machine tank chamber by nitrogen force feed or vacuum by import;
(2) washing process: add the technological process of acetone to the degreasing of thickness pulpous state pig brain; Steam is by heat exchanger or heat thermal conductive silicon oil/water by electrothermal tube, and heated thermal conductive silicon oil/water, by multi-functional washing filtering drying machine chuck circulating-heating material, is opened whipping appts simultaneously, and material is stirred.Acetone consumption is 300 ~ 1000kg, and pig brain consumption is 100 ~ 350kg, and skimming temp is 50 ~ 70 DEG C, and degreasing time is 1 ~ 3h, and mixing speed is 10 ~ 20 to turn, and is divided into three times and carries out;
(3) filtration process: the technological process of the solid-liquid separation under nitrogen pressurized state; Each degreasing is complete, passes into nitrogen by press filtration mouth in tank chamber, and pressure-controlling, at 0.1 ~ 0.3MPa, is discharged acetone mother liquor by filtration unit filtrate outlet;
(4) drying process: the technological process of volatilizing under vacuum negative pressure condition, open whipping appts, rotating speed is 10 ~ 20 to turn, opening the vacuum system being connected by basket filter outlet vacuumizes tank chamber, vacuum tightness is-0.05 ~-0.1MPa, heated thermal conductive silicon oil/water is by multi-functional washing filtering drying machine chuck circulating-heating material simultaneously, and temperature is 40 DEG C ~ 70 DEG C and carries out vacuum-drying 10 ~ 30min;
(5) self-emptying: the technological process of dry solid materials discharging after solid-liquid separation process process; Open the discharge door in drawing mechanism completely, open whipping appts simultaneously, material is stirred, mixing speed is 1 ~ 10 to turn, and material is by tank body discharge port, drawing mechanism outlet drain tank chamber, collection material, in the time that drawing mechanism is discharged without material, put down filtration unit, collect residual material.
In order to realize smoothly object of the present invention, the present invention has mainly completed following work:
One, task of the present invention is to utilize this device fabrication to go out the protein powder of high nitrogen content, and in the production process of protein powder, its total nitrogen increases gradually, more than bringing up to 120mg/g by initial 98mg/g.Its key point is the protein powder that existing production technique is conducive to produce high nitrogen content.
Two, the principle of work of multi-functional washing filtering drying machine is as follows:
(1) material loading: acetone is delivered in multi-functional washing filtering drying machine tank chamber with nitrogen by material inlet; Thickness pulpous state pig brain is drawn in multi-functional washing filtering drying machine tank chamber by nitrogen force feed or vacuum by import.
(2) washing process: steam is by heat exchanger or heat thermal conductive silicon oil/water by electrothermal tube, heated thermal conductive silicon oil/water is by multi-functional washing filtering drying machine chuck circulating-heating material, open whipping appts simultaneously, material is stirred, pass through stirring action, material is mixed, make material thermally equivalent, degreasing can fully be carried out.Acetone consumption is 300 ~ 1000kg, and pig brain consumption is 100 ~ 350kg, and skimming temp is 50 ~ 70 DEG C, and degreasing time is 1 ~ 3h, and mixing speed is 10 ~ 20 to turn, and is divided into three times and carries out.
(3) filtration process: each degreasing is complete, passes into nitrogen by press filtration mouth in tank chamber, and pressure-controlling, at 0.1 ~ 0.3MPa, is discharged acetone mother liquor by filtration unit filtrate outlet.Sintering filter screen in chassis is formed through braiding sintering by six layers of 316L Stainless Steel Wire, and filtering accuracy is 10～15 μ m.By to mother liquor composition analysis, there is few protein powder to see through sintering filter screen, illustrate that sintering filter screen can effectively catching pulverulent material.
(4) drying process: open whipping appts, rotating speed is 10 ~ 20 to turn, opening the vacuum system being connected by basket filter outlet vacuumizes tank chamber, vacuum tightness is-0.05 ~-0.1MPa, heated thermal conductive silicon oil/water is by multi-functional washing filtering drying machine chuck circulating-heating material simultaneously, and temperature is 40 DEG C ~ 70 DEG C and carries out vacuum-drying 10 ~ 30min.While carrying out vacuum operating, should first vacuumize chassis, and continue several minutes, just can vacuumize tank chamber.Agitating vane in whipping appts can stir material, contributes to the dry of material; Basket filter filtering net precision is 10～15 μ m, can effectively catching powder material, prevent that material from entering vacuum system.
(5) self-emptying: open the discharge door in drawing mechanism completely, open whipping appts simultaneously, material is stirred, mixing speed is 1 ~ 10 to turn, material is by tank body discharge port, drawing mechanism outlet drain tank chamber, collection material.In the time that drawing mechanism is discharged without material, put down filtration unit, collect residual material.
Three, key point of the present invention and focused protection point
Multi-functional washing filtering drying machine of the present invention, comprises tank body, whipping appts, filtration unit, locked clip device device, drawing mechanism, basket filter.
Tank body is multi-functional washing filtering drying machine main part, be fixed by supporting leg, inside has tank chamber and lower ending opening, mainly comprise top hand hole, material inlet, with the visor of wiper, look socket, vacuum orifice, corrugated tube Butterworth Hatch, press filtration mouth, pressure transmitter mouth, temperature sensor mouth, refluxing opening, tank body Butterworth Hatch, drain; Tank wall has chuck, and chuck top one side is furnished with one for the heating and cooling media outlet by drawing heating and cooling medium in chuck, is furnished with a heating and cooling medium import communicating with chuck in chuck bottom one side.Wherein: heating and cooling media outlet and the import of heating and cooling medium are at the homonymy of tank body.
Be provided with a whipping appts by stir shaft, stirring blade, metallic bellows, stir shaft hoist cylinder installation composition in multi-functional washing filtering drying machine inside along tank body central axis, this whipping appts top is connected with tank body top speed reducer output shaft, stir shaft is coated layer of metal corrugated tube, and the two ends of metallic bellows are connected with agitating vane with mechanical seal respectively.Whipping appts bottom is connected with S type+rake Double-layer stirring paddle leaf.By the lifting of stir shaft hoist cylinder device action control whipping appts.
Filtration unit is arranged on the bottom of tank body, and seals the bottom opening of this tank body.This filtration unit comprises its main part chassis, upper end, described chassis is provided with the filter plate of using for fixing filtering table, described filtering table is made up of some sintering filter screens, and lower end, described chassis is provided with chuck import and export, filtrate outlet, and filtration unit is by hanging oil gear control lifting.
Locked clip device device is arranged on tank body bottom, is made up of the ring-shaped clip, the rotation oil gear that are provided with internal tooth.
Drawing mechanism is fixed in tank body downside by welding.This drawing mechanism comprises the discharging cylindrical shell that is connected to discharge port place, described discharging cylindrical shell lower end is provided with drawing mechanism outlet, side is provided with drawing mechanism internal washing mouth, inside being provided with can be by the discharge door of discharge port sealing, the piston rod that described discharge door is connected with out-feed liquid pressure device is connected, described piston rod is coated with metallic bellows, and the two ends of described metallic bellows are connected with discharge door with discharging cylindrical shell respectively.The opening travel of discharge door is completed by out-feed liquid pressure device.This discharging cylindrical shell can be opened at rear end root, is beneficial to the discharge of leftover materials.In the time opening, need to unclamp the star grip knob on front end shell ring flange, then discharging cylinder back-end shell ring be opened along 90 degree.Be noted that, in the time opening rear end shell ring, out-feed liquid pressure device must be in contraction schedule.
Basket filter is connected with tank body top vacuum orifice by basket filter import, is connected with vacuum system by outlet.This basket filter comprises the basket filter chuck of basket filter outer wall, basket filter Butterworth Hatch-nitrogen back blow port at top, inner filtering net.Chuck top one side is furnished with one for the heating and cooling media outlet by drawing heating and cooling medium in chuck, is furnished with a heating and cooling medium import communicating with chuck in chuck bottom one side.Wherein: heating and cooling media outlet and the import of heating and cooling medium are angular dependence on basket filter.
Adopt multi-functional washing filtering drying machine to extract the production method of protein powder in animal tissues:
(1) material loading: organic solvent is delivered to the process in multi-functional washing filtering drying machine tank with nitrogen, thickness pulpous state biological tissue material is drawn to the process in multi-functional washing filtering drying machine by nitrogen force feed or vacuum.By material inlet, aequum acetone is delivered in multi-functional washing filtering drying machine tank chamber with nitrogen; Aequum thickness pulpous state pig brain is drawn in multi-functional washing filtering drying machine tank chamber by nitrogen force feed or vacuum by import.
(2) washing process: add the technological process of acetone to the degreasing of thickness pulpous state pig brain.Steam is by heat exchanger or heat thermal conductive silicon oil/water by electrothermal tube, and heated thermal conductive silicon oil/water, by multi-functional washing filtering drying machine chuck circulating-heating material, is opened whipping appts simultaneously, and material is stirred.Acetone consumption is 300 ~ 1000kg, and pig brain consumption is 100 ~ 350kg, and skimming temp is 50 ~ 70 DEG C, and degreasing time is 1 ~ 3h, and mixing speed is 10 ~ 20 to turn, and is divided into three times and carries out.
(3) filtration process: the technological process of the solid-liquid separation under nitrogen pressurized state.Each degreasing is complete, passes into nitrogen by press filtration mouth in tank chamber, and pressure-controlling, at 0.1 ~ 0.3MPa, is discharged acetone mother liquor by filtration unit filtrate outlet.
(4) drying process: the technological process of volatilizing under vacuum negative pressure condition.Open whipping appts, rotating speed is 10 ~ 20 to turn, opening the vacuum system being connected by basket filter outlet vacuumizes tank chamber, vacuum tightness is-0.05 ~-0.1MPa, heated thermal conductive silicon oil/water is by multi-functional washing filtering drying machine chuck circulating-heating material simultaneously, and temperature is 40 DEG C ~ 70 DEG C and carries out vacuum-drying 10 ~ 30min.While carrying out vacuum operating, should first vacuumize chassis, and continue several minutes, just can vacuumize tank chamber.
(5) self-emptying: the technological process of dry solid materials discharging after solid-liquid separation process process.Open the discharge door in drawing mechanism completely, open whipping appts simultaneously, material is stirred, mixing speed is 1 ~ 10 to turn, and material is by tank body discharge port, drawing mechanism outlet drain tank chamber, collection material.In the time that drawing mechanism is discharged without material, put down filtration unit, collect residual material.
The equipment correlation parameter of the multi-functional washing filtering drying machine that four, prepared by the present invention is as follows:
Five, the major function of each several part
1, supporting leg,, plays a supportive role totally by 3.
2, filtration unit: quick release, the sintering filter screen in chassis is formed through braiding sintering by six layers of 316L Stainless Steel Wire, and filtering accuracy is 10～15 μ m.
3, locked clip device device: for the locking to filtration unit.
4, basket filter: filtering accuracy is 10～15 μ m, for holding back powder material, prevents that material from entering vacuum system.
5, drawing mechanism: by the unlatching of discharge door, material is discharged.Discharging cylindrical shell can be opened at rear end root, is beneficial to the discharge of residue material powder.
6, tail rod: left and right is each, for fixed filter unit position.
7, rotate oil gear: left and right is each one, control the switch of clip by the action of oil cylinder.
8, hanging oil gear: totally 3, carry out the lifting of controlled filter device by the action of oil cylinder.
9, stir shaft hoist cylinder device: left and right is each, by the lifting of cylinder action control stir shaft.
10, whipping appts: formed by stir shaft, stirring blade, metallic bellows.Blade be 2 leaves have can scraping filter cake scraper, there is the special construction of extending filter cake plane blade bottom surface.Stir and can wash when forward and the stirring and drying of the stirring of the discharge of material, material, filter cake, when reversion, can extend.
11, filtrate outlet: mother liquor outlet after filtering.
12, visor: for observing material in tank state.
13,14, body chuck is imported and exported: for heating and cooling medium as the turnover such as steam, water coolant, silicone oil body chuck.
15, chassis chuck is imported and exported: for heating and cooling medium as the turnover such as steam, water coolant, silicone oil chassis chuck.
16,17, basket filter chuck is imported and exported: for heating and cooling medium as the turnover such as steam, water coolant, silicone oil basket filter chuck.
18, drawing mechanism outlet: for the discharge of material.
19, drawing mechanism internal washing mouth: for the cleaning to drawing mechanism inside, purging.
20, material inlet: enter in tank for pasty material.
21, press filtration mouth: connect for rare gas element pipelines such as nitrogen.
22, basket filter Butterworth Hatch-nitrogen back blow port: for the cleaning to basket filter, nitrogen purging.
23, vacuum orifice: for connecting vacuum pipe.
24, corrugated tube Butterworth Hatch: for the cleaning to stir shaft corrugated tube.
25, drain: for keeping atmospheric pressure state in tank, the special drain of preparing.
26, tank body: the main part of multi-functional washing filtering drying machine.
27, tank body chuck: comprise chuck import and export, for the refrigeration heating to tank body.
28, hand hole
29, depending on socket: look lamp for installing, be convenient to observe material state in tank.
30, pressure transmitter mouth: for setting pressure sensor.
31, temperature sensor mouth: for mounting temperature sensor.
32, refluxing opening: for the backflow of organic solvent.
33, tank body Butterworth Hatch: inside establish spray ball, for the cleaning in tank.
34, stir shaft: be connected the integral part of whipping appts with speed reducer output shaft.
35, stirring blade: can wash and the stirring and drying of the stirring of the discharge of material, material, filter cake, can extend when reversion.
36, stir shaft metallic bellows: be coated on stir shaft outside.
37, step-down gear: for reducing mixing speed.
38, ring-shaped clip: for the locking to filtration unit.
39, discharging cylindrical shell: the main part of drawing mechanism, inside sets out bin gate, piston rod, metallic bellows etc.
40, discharge port: be connected with discharging cylindrical shell, for the discharge of material.
41, discharge door: for sealing discharge port.
42, out-feed liquid pressure device: control sealing or the unlatching of discharge door to discharge port by cylinder action.
43, piston rod: be connected with discharge door, for the sealing to discharge port or unlatching.
44, piston rod metallic bellows: be coated on piston rod outside.
45, star grip knob: for the locking after the front end to discharging cylindrical shell and the connection of rear end shell ring.
46, basket filter import: for connecting tank body vacuum port.
47, basket filter outlet: for connecting vacuum system.
48, basket filter chuck: comprise chuck import and export, for the refrigeration heating to basket filter.
49, material inlet: enter in tank for organic solvent.
50, tank chamber: for the filling of material.
51, rear end shell ring: discharging cylindrical shell rear end part.
52, front end shell ring: discharging cylindrical shell fore-end.
53, visor wiper: be positioned at tank body visor upper surface, for the condensation material of wiper mirror surface, facilitate in tank and observe.
54, mechanical seal: for the sealing to surrounding gap, stir shaft place, prevent that foreign matter from entering in tank.
55, filtering table: formed by some sintering filter screens.
56, filter plate: be used for fixing to filtering table.
57, chassis: the main part of filtration unit.
58, basket filter filtering net: for holding back pulverulent material.
The present invention further discloses the production method that adopts multi-functional washing filtering drying machine to extract protein powder in animal tissues application aspect the total nitrogen content of protein powder in preparation improves animal tissues.Adopt more than protein powder total nitrogen that equipment of the present invention is produced reaches 120mg/g.
Brief description of the drawings
Fig. 1 is multi-functional washing filtering drying machine sectional structure schematic diagram;
Fig. 2 is multi-functional washing filtering drying machine plan structure schematic diagram;
Fig. 3 is the structural representation of whipping appts agitating vane;
Wherein
1, supporting leg 2, filtration unit 3, locked clip device device 4, basket filter
5, drawing mechanism 6, tail rod 7, rotation oil gear 8, hanging oil gear
9, stir shaft hoist cylinder device 10, whipping appts 11, filtrate outlet
12, visor 13,14, body chuck import and export 15, filter disc chuck are imported and exported
16,17, basket filter chuck import and export 18, drawing mechanism outlet 19, drawing mechanism internal washing mouth
20, material inlet 21, press filtration mouth 22, basket filter Butterworth Hatch-nitrogen back blow port
23, vacuum orifice 24, corrugated tube Butterworth Hatch 25, drain
26, tank body 27, tank body chuck 28, hand hole
29, look socket 30, pressure transmitter 31, temperature sensor
32, refluxing opening 33, tank body Butterworth Hatch 34, stir shaft
35, agitating vane 36, stir shaft metallic bellows 37, step-down gear
38, ring-shaped clip 39, discharging cylindrical shell 40, discharge port
41, discharge door 42, out-feed liquid pressure device 43, piston rod
44, piston rod metallic bellows 45, star grip knob 46, basket filter import
47, basket filter outlet 48, basket filter chuck 49, material inlet
50, tank chamber 51, rear end shell ring 52, front end shell ring
53, visor wiper 54, mechanical seal 55, filtering table
56, filter plate 57, chassis 58, basket filter filtering net.
Embodiment
Referring to drawings and Examples, the present invention will be described in detail.Following each embodiment is not only limitation of the present invention for the present invention is described.Experimental technique in following embodiment, if no special instructions, is ordinary method.
Embodiment 1
Fig. 1 is sectional structure schematic diagram of the present invention; Fig. 2 is plan structure schematic diagram; Fig. 3 is whipping appts agitating vane structural representation.
A kind of multi-functional washing filtering drying machine, it comprises tank body 26, whipping appts 10, filtration unit 2, locked clip device device 3, drawing mechanism 5, basket filter 4; Tank body mainly comprises top hand hole 28, material inlet 20,49, with the visor 12 of wiper, look socket 29, vacuum orifice 23, corrugated tube Butterworth Hatch 24, press filtration mouth 21, pressure transmitter mouth 30, temperature sensor mouth 31, refluxing opening 32, tank body Butterworth Hatch 33, drain 25.
Filtration unit is arranged on the bottom of tank body and seals the bottom opening of this tank body, locked clip device device is arranged on tank body lower end and is used for locking filtration unit, drawing mechanism is fixed in tank body downside by welding, whipping appts is on tank body central axis, its top is connected with tank body top step-down gear 37 output shafts, basket filter is connected with tank body top vacuum orifice by import 46, is connected with vacuum system by exporting 47; The coated layer of metal corrugated tube 36 of whipping appts main part stir shaft 34, the two ends of metallic bellows are connected with agitating vane 35 with mechanical seal 54 respectively, agitating vane be 2 leaves have can scraping filter cake scraper, there is the structure of extending filter cake plane blade bottom surface, stir and can wash when forward and the stirring and drying of the stirring of the discharge of material, material, filter cake, when reversion, can extend.
Whipping appts bottom is connected with S type+rake Double-layer stirring paddle leaf, by the lifting of stir shaft hoist cylinder device 9 action control whipping apptss; Drawing mechanism comprises the discharging cylindrical shell 39 that is connected to discharge port 40 places, and described discharging cylindrical shell lower end is provided with drawing mechanism outlet 18, and side is provided with drawing mechanism internal washing mouth 19, and being inside provided with can be by the discharge door 41 of discharge port sealing;
Tank body is fixed by supporting leg 1, inside has tank chamber 50 and lower ending opening, tank wall has chuck 27, chuck top one side is furnished with one for the heating and cooling media outlet 14 by drawing heating and cooling medium in chuck, is furnished with a heating and cooling medium import 13 communicating with chuck in chuck bottom one side, wherein: heating and cooling media outlet and the import of heating and cooling medium are at the homonymy of tank body; 57 upper ends, filtration unit main part chassis are provided with the filter plate 56 for fixing filtering table 55 use, and filtering table is made up of some sintering filter screens, and lower end, chassis is provided with chuck import and export 15, filtrate outlet 11, and filtration unit is controlled lifting by hanging oil gear 8;
Locked clip device device is made up of the ring-shaped clip 38, the rotation oil gear 7 that are provided with internal tooth;
Basket filter comprises the basket filter chuck 48 of basket filter outer wall, basket filter Butterworth Hatch-nitrogen back blow port 22 at top, inner filtering net 58; Chuck top one side is furnished with one for the heating and cooling media outlet 17 by drawing heating and cooling medium in chuck, is furnished with a heating and cooling medium import 16 communicating with chuck in chuck bottom one side, wherein: heating and cooling media outlet and the import of heating and cooling medium are angular dependence on basket filter.
The sintering filter screen that has six layers of 316L Stainless Steel Wire braiding in chassis of the present invention, filtering accuracy is 10～15 μ m; The filtering accuracy of described basket filter is 10～15 μ m.
The piston rod 43 that the discharge door of drawing mechanism of the present invention is connected with out-feed liquid pressure device 42 is connected, described piston rod is coated with metallic bellows 44, the two ends of described metallic bellows are connected with discharge door with discharging cylindrical shell respectively, the opening travel of discharge door is completed by out-feed liquid pressure device, this discharging cylindrical shell can be opened at rear end root, be beneficial to the discharge of leftover materials, in the time opening, need to unclamp the star grip knob 45 on front end shell ring 52 flanges, then discharging cylinder back-end shell ring 51 be opened along 90 degree.
Embodiment 2
As depicted in figs. 1 and 2, multi-functional washing filtering drying machine tank body, be fixed by supporting leg, inside has tank chamber and lower ending opening, mainly comprise top hand hole, material inlet, with the visor of wiper, look socket, vacuum orifice, corrugated tube Butterworth Hatch, press filtration mouth, pressure transmitter mouth, temperature sensor mouth, refluxing opening, tank body Butterworth Hatch, drain; Tank wall has chuck, and chuck top one side is furnished with one for the heating and cooling media outlet by drawing heating and cooling medium in chuck, is furnished with a heating and cooling medium import communicating with chuck in chuck bottom one side.Wherein: heating and cooling media outlet and the import of heating and cooling medium are at the homonymy of tank body.Heating and cooling medium can be both steam as the aforementioned, can be also water coolant/hot water, can be also silicone oil.
As shown in figures 1 and 3, be provided with a whipping appts by stir shaft, agitating vane, metallic bellows, stir shaft hoist cylinder installation composition in multi-functional washing filtering drying machine inside along tank body central axis, this whipping appts top is connected with tank body top speed reducer output shaft, stir shaft is coated layer of metal corrugated tube, and the two ends of metallic bellows are connected with agitating vane with mechanical seal respectively.Whipping appts bottom is connected with S type+rake Double-layer stirring paddle leaf.By the lifting of stir shaft hoist cylinder device action control whipping appts.Foregoing agitating vane be 2 leaves have can scraping filter cake scraper, there is the structure of extending filter cake plane blade bottom surface, stir and can wash when forward and the stirring and drying of the stirring of the discharge of material, material, filter cake, when reversion, can extend.
As shown in Figure 1, filtration unit is arranged on the bottom of tank body, and seals the bottom opening of this tank body.This filtration unit comprises its main part chassis, and upper end, described chassis is provided with the filter plate of using for fixing filtering table, and described filtering table is made up of some sintering filter screens, and lower end, described chassis is provided with chuck import and export, filtrate outlet.Filtration unit is by hanging oil gear control lifting.The sintering filter screen that has six layers of 316L Stainless Steel Wire braiding in foregoing chassis, filtering accuracy is 10～15 μ m, preferably 10 μ m.
As shown in figures 1 and 3, locked clip device device is arranged on tank body bottom, is made up of the ring-shaped clip, the rotation oil gear that are provided with internal tooth.
As shown in Figure 1, drawing mechanism is fixed in tank body downside by welding.This drawing mechanism comprises the discharging cylindrical shell that is connected to discharge port place, described discharging cylindrical shell lower end is provided with drawing mechanism outlet, side is provided with drawing mechanism internal washing mouth, inside being provided with can be by the discharge door of discharge port sealing, the piston rod that described discharge door is connected with out-feed liquid pressure device is connected, described piston rod is coated with metallic bellows, and the two ends of described metallic bellows are connected with discharge door with discharging cylindrical shell respectively.The opening travel of discharge door is completed by out-feed liquid pressure device.This discharging cylindrical shell can be opened at rear end root, is beneficial to the discharge of leftover materials.In the time opening, need to unclamp the star grip knob on front end shell ring flange, then discharging cylinder back-end shell ring be opened along 90 degree.As previously mentioned, in the time opening rear end shell ring, out-feed liquid pressure device must be in contraction schedule.Basket filter is connected with tank body top vacuum orifice by basket filter import, is connected with vacuum system by outlet.This basket filter comprises the basket filter chuck of basket filter outer wall, basket filter Butterworth Hatch-nitrogen back blow port at top, inner filtering net.Chuck top one side is furnished with one for the heating and cooling media outlet by drawing heating and cooling medium in chuck, is furnished with a heating and cooling medium import communicating with chuck in chuck bottom one side.Wherein: heating and cooling media outlet and the import of heating and cooling medium are angular dependence on basket filter.Heating and cooling medium can be both steam as the aforementioned, can be also water coolant/hot water, can be also silicone oil.The filtering accuracy of foregoing basket filter is 10～15 μ m, preferably 10 μ m.
Embodiment 3
Adopt multi-functional washing filtering drying machine to extract the production method of protein powder in animal tissues:
(1) material loading: organic solvent is delivered to the process in multi-functional washing filtering drying machine tank with nitrogen, thickness pulpous state biological tissue material is drawn to the process in multi-functional washing filtering drying machine by nitrogen force feed or vacuum.By material inlet, aequum acetone is delivered in multi-functional washing filtering drying machine tank chamber with nitrogen; Aequum thickness pulpous state pig brain is drawn in multi-functional washing filtering drying machine tank chamber by nitrogen force feed or vacuum by import.
(2) washing process: add the technological process of acetone to the degreasing of thickness pulpous state pig brain.Steam is by heat exchanger or heat thermal conductive silicon oil/water by electrothermal tube, and heated thermal conductive silicon oil/water, by multi-functional washing filtering drying machine chuck circulating-heating material, is opened whipping appts simultaneously, and material is stirred.Acetone consumption is 500kg, and pig brain consumption is 150kg, and skimming temp is 50 ~ 70 DEG C, and degreasing time is 1 ~ 3h(preferably 2 hours), mixing speed is 10 ~ 20 to turn, and is divided into three times and carries out.
(3) filtration process: the technological process of the solid-liquid separation under nitrogen pressurized state.Each degreasing is complete, passes into nitrogen by press filtration mouth in tank chamber, and pressure-controlling is at the preferred 0.2MPa of 0.1 ~ 0.3MPa(), acetone mother liquor is discharged by filtration unit filtrate outlet.
(4) drying process: the technological process of volatilizing under vacuum negative pressure condition.Open whipping appts, rotating speed is 10 ~ 20 to turn, opening the vacuum system being connected by basket filter outlet vacuumizes tank chamber, vacuum tightness is preferably-0.07 MPa of-0.05 ~-0.1MPa(), heated thermal conductive silicon oil/water is by multi-functional washing filtering drying machine chuck circulating-heating material simultaneously, and temperature is that 40 DEG C ~ 70 DEG C (preferably 50 DEG C) carry out vacuum-drying 10 ~ 30min.While carrying out vacuum operating, should first vacuumize chassis, and continue several minutes, just can vacuumize tank chamber.
(5) self-emptying: the technological process of dry solid materials discharging after solid-liquid separation process process.Open the discharge door in drawing mechanism completely, open whipping appts simultaneously, material is stirred, mixing speed is 1 ~ 10 to turn, and material is by tank body discharge port, drawing mechanism outlet drain tank chamber, collection material.In the time that drawing mechanism is discharged without material, put down filtration unit, collect residual material.
Embodiment 4
Adopting this equipment institute production of albumen powder is Cerebrolysin Vial intermediate, and its method is as follows:
(1) the just mixed thing of preparation: adopt fresh pig brain tissue appropriate, water cleans up the water of dehematizing, and every kg cerebral tissue adds 0.5g N,O-Diacetylmuramidase to be mixed together stirring, colloidal mill homogenate, through 6 homogenate, obtains just mixed thing;
(2) heating, degreasing: will just mix thing heated and boiled lh, and be cooled to normal temperature, and then add 20 times of (weight) acetone, and stir 1h; Filter, Air drying, obtaining total nitrogen content is 128mg/g metaprotein powder ,-20 DEG C of following preservations.This production method is easy to control, and steady quality is convenient to preserve, and is convenient to the carrying out of hydrolysis process.
Claims (7)
1. the multi-functional extraction filtering drying machine of protein powder, is characterized in that it comprises tank body (26), whipping appts (10), filtration unit (2), locked clip device device (3), drawing mechanism (5), basket filter (4); Filtration unit (2) is arranged on the bottom of tank body (26) and seals the bottom opening of this tank body, locked clip device device (3) is arranged on tank body (26) lower end and is used for locking filtration unit (2), drawing mechanism (5) is fixed in tank body (26) downside by welding, whipping appts (10) is on tank body (26) central axis, its top is connected with tank body (26) top step-down gear (37) output shaft, basket filter (4) is connected with tank body (26) top vacuum orifice (23) by import (46), is connected with vacuum system by outlet (47); Wherein said
Tank body (26) is fixed by supporting leg (1), inside has tank chamber (50) and lower ending opening, tank wall has chuck (27), chuck top one side is furnished with one for the heating and cooling media outlet (14) by drawing heating and cooling medium in chuck, is furnished with a heating and cooling medium import (13) communicating with chuck in chuck bottom one side, wherein: heating and cooling media outlet (14) and the homonymy of heating and cooling medium import (13) in tank body (26);
Upper end, filtration unit (2) main part chassis (57) is provided with the filter plate (56) for fixing filtering table (55) use, filtering table (55) is made up of some sintering filter screens, lower end, chassis (57) is provided with chuck and imports and exports (15), filtrate outlet (11), and filtration unit (2) is controlled lifting by hanging oil gear (8);
Whipping appts (10) main part stir shaft (34) is coated layer of metal corrugated tube (36), the two ends of metallic bellows (36) are connected with agitating vane (35) with mechanical seal (54) respectively, whipping appts (10) bottom is connected with S type+rake Double-layer stirring paddle leaf (35), by the lifting of stir shaft hoist cylinder device (9) action control whipping appts (10);
Locked clip device device (3) is made up of the ring-shaped clip (38), the rotation oil gear (7) that are provided with internal tooth;
Drawing mechanism (5) comprises and is connected to the discharging cylindrical shell (39) that discharge port (40) is located, described discharging cylindrical shell (39) lower end is provided with drawing mechanism outlet (18), side is provided with drawing mechanism internal washing mouth (19), and being inside provided with can be by the discharge door (41) of discharge port (40) sealing;
Basket filter (4) comprises the basket filter chuck (48) of basket filter (4) outer wall, basket filter Butterworth Hatch-nitrogen back blow port (22) at top, inner filtering net (58); Chuck top one side is furnished with one for the heating and cooling media outlet (17) by drawing heating and cooling medium in chuck, is furnished with a heating and cooling medium import (16) communicating with chuck in chuck bottom one side, wherein: heating and cooling media outlet (17) is angular dependence on basket filter (4) with heating and cooling medium import (16).
2. the multi-functional extraction filtering drying machine of protein powder according to claim 1, it is characterized in that described tank body (26) mainly comprise top hand hole (28), material inlet (20,49), with the visor (12) of wiper, look socket (29), vacuum orifice (23), corrugated tube Butterworth Hatch (24), press filtration mouth (21), pressure transmitter mouth (30), temperature sensor mouth (31), refluxing opening (32), tank body Butterworth Hatch (33), drain (25).
3. the multi-functional extraction filtering drying machine of protein powder according to claim 1, the sintering filter screen that has six layers of 316L Stainless Steel Wire to weave in the chassis (57) described in it is characterized in that, filtering accuracy is 10～15 μ m; The filtering accuracy of described basket filter (4) is 10～15 μ m.
4. the multi-functional extraction filtering drying machine of protein powder according to claim 1, the piston rod (43) that the discharge door (41) of the drawing mechanism (5) described in it is characterized in that is connected with out-feed liquid pressure device (42) is connected, described piston rod (43) is coated with metallic bellows (44), the two ends of described metallic bellows (44) are connected with discharge door (41) with discharging cylindrical shell (39) respectively, the opening travel of discharge door (41) is completed by out-feed liquid pressure device (42), this discharging cylindrical shell (39) can be opened at rear end root, be beneficial to the discharge of leftover materials, in the time opening, need to unclamp the star grip knob (45) on front end shell ring (52) flange, then discharging cylinder back-end shell ring (51) is opened along 90 degree.
5. the multi-functional extraction filtering drying machine of protein powder according to claim 1, it is characterized in that described agitating vane (35) be 2 leaves have can scraping filter cake scraper, there is the structure of extending filter cake plane blade bottom surface, stir and can wash when forward and the stirring and drying of the stirring of the discharge of material, material, filter cake, when reversion, can extend.
6. adopt the multi-functional extraction filtering drying machine of protein powder claimed in claim 1 to extract the production method of protein powder in animal tissues, it is characterized in that being undertaken by following step:
(1) material loading: organic solvent is delivered to the process in multi-functional washing filtering drying machine with nitrogen, thickness pulpous state biological tissue material is drawn to the process in multi-functional washing filtering drying machine by nitrogen force feed or vacuum; By material inlet, aequum acetone is delivered in multi-functional washing filtering drying machine tank chamber with nitrogen; Aequum thickness pulpous state pig brain is drawn in multi-functional washing filtering drying machine tank chamber by nitrogen force feed or vacuum by import;
(2) washing process: add the technological process of acetone to the degreasing of thickness pulpous state pig brain; Steam is by heat exchanger or heat thermal conductive silicon oil/water by electrothermal tube, heated thermal conductive silicon oil/water is by multi-functional washing filtering drying machine chuck circulating-heating material, open whipping appts simultaneously, material is stirred, and acetone consumption is 300 ~ 1000kg, and pig brain consumption is 100 ~ 350kg, skimming temp is 50 ~ 70 DEG C, degreasing time is 1 ~ 3h, and mixing speed is 10 ~ 20 to turn, and is divided into three times and carries out;
(3) filtration process: the technological process of the solid-liquid separation under nitrogen pressurized state; Each degreasing is complete, passes into nitrogen by press filtration mouth in tank chamber, and pressure-controlling, at 0.1 ~ 0.3MPa, is discharged acetone mother liquor by filtration unit filtrate outlet;
(4) drying process: the technological process of volatilizing under vacuum negative pressure condition; Open whipping appts, rotating speed is 10 ~ 20 to turn, opening the vacuum system being connected by basket filter outlet vacuumizes tank chamber, vacuum tightness is-0.05 ~-0.1MPa, heated thermal conductive silicon oil/water is by multi-functional washing filtering drying machine chuck circulating-heating material simultaneously, and temperature is 40 DEG C ~ 70 DEG C and carries out vacuum-drying 10 ~ 30min;
(5) self-emptying: the technological process of dry solid materials discharging after solid-liquid separation process process; Open the discharge door in drawing mechanism completely, open whipping appts simultaneously, material is stirred, mixing speed is 1 ~ 10 to turn, and material is by tank body discharge port, drawing mechanism outlet drain tank chamber, collection material, in the time that drawing mechanism is discharged without material, put down filtration unit, collect residual material.
7. the production method that adopts the multi-functional extraction filtering drying machine of protein powder to extract protein powder in animal tissues described in claim 6 improves the application aspect the total nitrogen content of protein powder in animal tissues in preparation.
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| CN111603802A (en) * | 2020-05-10 | 2020-09-01 | 上海灿实工程设备有限公司 | Adsorption tank for blood products |
| CN111715164A (en) * | 2020-05-29 | 2020-09-29 | 国家能源集团宁夏煤业有限责任公司 | Reaction kettle |
| WO2022016870A1 (en) * | 2020-07-21 | 2022-01-27 | 合肥通用机械研究院有限公司 | Integrated production system for ternary material |
| CN115137007A (en) * | 2022-07-04 | 2022-10-04 | 四川大学华西医院 | A defatted albumen powder system of processing for albumen powder production |
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Address after: 072656 Hebei city of Baoding province Dingxing Gucheng No. 1 Patentee after: Hebei wisdom biopharmaceutical Limited by Share Ltd Address before: 072656 Hebei city of Baoding province Dingxing Gucheng No. 1 Patentee before: Hebei Zhi Tong Biology Pharmacy Co., Ltd |