CN103974883A - Ptp or blister package sheet for packaging pharmaceutical product, ptp or blister package for packaging pharmaceutical product using same, and method for producing ptp or blister package for packaging pharmaceutical product - Google Patents
Ptp or blister package sheet for packaging pharmaceutical product, ptp or blister package for packaging pharmaceutical product using same, and method for producing ptp or blister package for packaging pharmaceutical product Download PDFInfo
- Publication number
- CN103974883A CN103974883A CN201280059892.1A CN201280059892A CN103974883A CN 103974883 A CN103974883 A CN 103974883A CN 201280059892 A CN201280059892 A CN 201280059892A CN 103974883 A CN103974883 A CN 103974883A
- Authority
- CN
- China
- Prior art keywords
- ptp
- blister package
- sheet material
- pharmaceuticals
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000004806 packaging method and process Methods 0.000 title claims abstract description 13
- 238000004519 manufacturing process Methods 0.000 title claims description 21
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 4
- 229940127557 pharmaceutical product Drugs 0.000 title abstract 4
- 239000000049 pigment Substances 0.000 claims abstract description 62
- 229920005989 resin Polymers 0.000 claims abstract description 48
- 239000011347 resin Substances 0.000 claims abstract description 48
- 239000002270 dispersing agent Substances 0.000 claims abstract description 16
- 239000000463 material Substances 0.000 claims description 101
- 239000000203 mixture Substances 0.000 claims description 77
- 239000003814 drug Substances 0.000 claims description 46
- 238000000034 method Methods 0.000 claims description 40
- 238000004040 coloring Methods 0.000 claims description 38
- -1 polypropylene Polymers 0.000 claims description 20
- 239000004743 Polypropylene Substances 0.000 claims description 9
- 229920001155 polypropylene Polymers 0.000 claims description 9
- 238000012856 packing Methods 0.000 claims description 7
- 239000004698 Polyethylene Substances 0.000 claims description 5
- 150000002148 esters Chemical class 0.000 claims description 5
- 229920000573 polyethylene Polymers 0.000 claims description 5
- 229920002493 poly(chlorotrifluoroethylene) Polymers 0.000 claims description 3
- 239000005023 polychlorotrifluoroethylene (PCTFE) polymer Substances 0.000 claims description 3
- 239000002245 particle Substances 0.000 abstract description 3
- 239000010410 layer Substances 0.000 description 25
- 238000001125 extrusion Methods 0.000 description 9
- 230000008569 process Effects 0.000 description 8
- 239000003963 antioxidant agent Substances 0.000 description 6
- 230000003078 antioxidant effect Effects 0.000 description 6
- 229910052760 oxygen Inorganic materials 0.000 description 6
- 239000001301 oxygen Substances 0.000 description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 5
- 230000004888 barrier function Effects 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 229920001577 copolymer Polymers 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 229920001169 thermoplastic Polymers 0.000 description 5
- 239000004416 thermosoftening plastic Substances 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 238000011049 filling Methods 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000000805 composite resin Substances 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 229920001903 high density polyethylene Polymers 0.000 description 3
- 239000004700 high-density polyethylene Substances 0.000 description 3
- 229920001684 low density polyethylene Polymers 0.000 description 3
- 239000004702 low-density polyethylene Substances 0.000 description 3
- 238000002844 melting Methods 0.000 description 3
- 230000008018 melting Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 238000010298 pulverizing process Methods 0.000 description 3
- 238000002834 transmittance Methods 0.000 description 3
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 description 2
- 230000002745 absorbent Effects 0.000 description 2
- 239000002250 absorbent Substances 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 229920005648 ethylene methacrylic acid copolymer Polymers 0.000 description 2
- 229920006244 ethylene-ethyl acrylate Polymers 0.000 description 2
- 229920006225 ethylene-methyl acrylate Polymers 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 239000011888 foil Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 229920000554 ionomer Polymers 0.000 description 2
- 238000003475 lamination Methods 0.000 description 2
- 229920001179 medium density polyethylene Polymers 0.000 description 2
- 239000004701 medium-density polyethylene Substances 0.000 description 2
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 2
- 229920001083 polybutene Polymers 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- 239000011164 primary particle Substances 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 238000007493 shaping process Methods 0.000 description 2
- 238000004611 spectroscopical analysis Methods 0.000 description 2
- 238000007666 vacuum forming Methods 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 238000003466 welding Methods 0.000 description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000004642 Polyimide Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical group C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical class [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 229920006243 acrylic copolymer Polymers 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 125000002723 alicyclic group Chemical group 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 239000005030 aluminium foil Substances 0.000 description 1
- 150000004056 anthraquinones Chemical class 0.000 description 1
- 239000002216 antistatic agent Substances 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000004567 concrete Substances 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000003851 corona treatment Methods 0.000 description 1
- 238000002788 crimping Methods 0.000 description 1
- 150000003997 cyclic ketones Chemical class 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 239000005038 ethylene vinyl acetate Substances 0.000 description 1
- 239000005042 ethylene-ethyl acrylate Substances 0.000 description 1
- FPVGTPBMTFTMRT-NSKUCRDLSA-L fast yellow Chemical compound [Na+].[Na+].C1=C(S([O-])(=O)=O)C(N)=CC=C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 FPVGTPBMTFTMRT-NSKUCRDLSA-L 0.000 description 1
- 235000019233 fast yellow AB Nutrition 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 238000005227 gel permeation chromatography Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000012760 heat stabilizer Substances 0.000 description 1
- 238000007731 hot pressing Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000001023 inorganic pigment Substances 0.000 description 1
- 239000011229 interlayer Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 239000004611 light stabiliser Substances 0.000 description 1
- 229920000092 linear low density polyethylene Polymers 0.000 description 1
- 239000004707 linear low-density polyethylene Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000001883 metal evaporation Methods 0.000 description 1
- 239000012860 organic pigment Substances 0.000 description 1
- 150000002926 oxygen Chemical class 0.000 description 1
- 235000021485 packed food Nutrition 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920001721 polyimide Polymers 0.000 description 1
- 229920005673 polypropylene based resin Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 238000007781 pre-processing Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- IZMJMCDDWKSTTK-UHFFFAOYSA-N quinoline yellow Chemical class C1=CC=CC2=NC(C3C(C4=CC=CC=C4C3=O)=O)=CC=C21 IZMJMCDDWKSTTK-UHFFFAOYSA-N 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 238000007652 sheet-forming process Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003856 thermoforming Methods 0.000 description 1
- JOUDBUYBGJYFFP-FOCLMDBBSA-N thioindigo Chemical class S\1C2=CC=CC=C2C(=O)C/1=C1/C(=O)C2=CC=CC=C2S1 JOUDBUYBGJYFFP-FOCLMDBBSA-N 0.000 description 1
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical class [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D65/00—Wrappers or flexible covers; Packaging materials of special type or form
- B65D65/02—Wrappers or flexible covers
- B65D65/16—Wrappers or flexible covers with provision for excluding or admitting light
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/18—Layered products comprising a layer of synthetic resin characterised by the use of special additives
- B32B27/20—Layered products comprising a layer of synthetic resin characterised by the use of special additives using fillers, pigments, thixotroping agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
- B65D81/30—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants by excluding light or other outside radiation
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/0008—Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
- C08K5/0041—Optical brightening agents, organic pigments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
- A61J1/035—Blister-type containers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2439/00—Containers; Receptacles
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K2201/00—Specific properties of additives
- C08K2201/002—Physical properties
- C08K2201/003—Additives being defined by their diameter
Landscapes
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Mechanical Engineering (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Packages (AREA)
- Wrappers (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Laminated Bodies (AREA)
Abstract
The PTP or blister package sheet for packaging a pharmaceutical product of the present invention contains a component (A) obtained by mixing an organic colored pigment (a1) having an average particle diameter of 20 to 400 nm and a dispersant (a2) having a number-average molecular weight of 100 to 3,000, and a resin component (B). Therefore, it is possible to obtain a sheet for forming a PTP or blister package (PTP or blister package sheet) with which good dispersibility of the organic colored pigment can be realized (there is little nonuniformity of the organic colored pigment throughout the sheet) and bleed-out of organic colored pigment can be reduced (or there is none of this bleed-out).
Description
Technical field
The present invention relates to a kind of for pack pharmaceuticals, PTP with or blister package sheet material and use the pharmaceuticals of this sheet material pack pack use blister package with PTP or pharmaceuticals, and pharmaceuticals are packed and are packed the manufacture method with blister package with PTP or pharmaceuticals.In more detail, relate to organic coloring pigment contained in a kind of sheet material can bring into play good dispersed for the PTP that packs pharmaceuticals with or blister package sheet material, use pharmaceuticals packaging PTP or the pharmaceuticals of this sheet material to pack with blister package, and pharmaceuticals packaging is packed the manufacture method with blister package with PTP or pharmaceuticals.
Background technology
At present, blister package is for contents such as medicament or food, toy (packed article) such as package troche, capsules.Especially,, as a kind of PTP (Press-through pack, extrusion type packaging) of blister package, be widely used in the medicament such as package troche and capsule.
Such blister package is the multiple vallecular cavities of thermoforming on the surface of banded resin sheet (sheet material, PTP sheet material for blister package), in each vallecular cavity of formed thereby, load content, on surface resin film, add the content that sealed foil (cover) that thermal bonding has (aluminium foils etc.) such as metallic papers seals filling and manufacture.
In addition, blister package, except formability and the transparency, according to the character of content, also requires various characteristics (low oxygen permeability, moisture resistance, UV shielding etc.) etc.
For example, in patent documentation 1, disclosed the blister package that a kind of oxygen flow degree compared with the past is lower and formed the blister package with laminated resin film and this film of use.This blister package forms the support base material with laminated resin film with this laminated resin film, be disposed at its side in opposite directions on oxygen barrier layers, and be disposed at this oxygen barrier layers with the not damp course in a side in opposite directions of support base material.
In addition, in patent documentation 2, disclosed a kind of sliding high in moisture resistance, sheet surface good in, the PTP sheet material that even also do not break than vallecular cavity portion the thinner thin-walled property of 250 μ m in sheet material gross thickness, shape and block be good, can stand actual use.This PTP sheet material is characterised in that, on stacked film, under rated condition, be shaped and multiplely accommodate vallecular cavity and form, this stacked film forms by the stacked skin being made up of specific polypropylene-based resin on the two sides at the interlayer being made up of the poly-mer that contains specific alicyclic structure.
In addition, in these patent documentation, disclose by add ultraviolet absorbent or light-proofness material (organic coloring pigment etc.) in sheet material, reduce in the PTP that obtains the scheme (patent documentation 1: paragraph [0058]～[0062], patent documentation 2: paragraph [0044]) of deteriorated (variable color, rotten) of the content causing because of visible light or ultraviolet ray.
Prior art document
Patent documentation
Patent documentation 1: No. 2008/156039 text of International Publication
Patent documentation 2: Japanese Patent Laid-Open 2005-263287 communique
Summary of the invention
Invent technical matters to be solved
But, in sheet material contained organic coloring pigment be difficult in resin dispersed, this tinting pigment easily concentrate exist.For this reason, in manufacturing the formed products such as PTP or blister package, in sheet material, easily produce the unfavorable conditions such as the aggegation of pigment or sheet surface be bad, the leeway being still improved in formability.In addition, because organic coloring pigment easily oozes out from formed products or sheet material, even organic coloring pigment have cover, scattering or absorb ultraviolet effect, in such formed products, also can there is the inadequate part of UV shielding (producing uneven) in UV shielding, consequently, can not bring into play on the whole good UV shielding.
For current such problem, present inventor conscientiously studies rear discovery, use in sheet material in blister package, by and with resinous principle with by thering is the organic coloring pigment of specific mean grain size and thering is compound prepared by specified molecular weight dispersant, can be in the dispersiveness (the less concentrated existence of organic coloring pigment in sheet material) of the good organic coloring pigment of performance, reduce the generation of oozing out (or this does not occur ooze out) of organic coloring pigment.
So, due to this good dispersiveness, manufacture the formed products such as PTP or blister package if use this sheet material, find: (i) formability is good, (ii) have and cover at organic coloring pigment, scattering or absorb in the situation of ultraviolet effect, the formed products obtaining (is concentrated and is existed less) on the whole from formed products and can bring into play good UV shielding, (iii) especially, this sheet material contains to have and covers, the organic coloring pigment of scattering or absorption action of ultraviolet radiation, by this sheet forming and PTP or blister package be suitable for packaging easily because of UV degradation or rotten pharmaceuticals etc.
; the object of this invention is to provide in the good dispersion that can bring into play organic coloring pigment (the concentrated existence of the organic coloring pigment in sheet material is few), can reduce organic coloring pigment ooze out generation (or this does not occur ooze out) be suitable for packing the PTP of pharmaceuticals or the sheet material of blister package (PTP with or blister package sheet material) for being shaped.
The technical scheme that technical solution problem adopts
It is of the present invention that for packing, the PTP of pharmaceuticals uses or blister package sheet material is characterised in that, the composition (A) that the dispersing agent (a2) that the organic coloring pigment (a1) that contains the mean grain size with 20～400nm and number-average molecular weight are 100～3000 mixes, and resinous principle (B).
PTP of the present invention uses or blister package is used in sheet material, with respect to the above-mentioned resinous principle (B) of 100 mass parts, preferably contains the composition (A) of the amount of 0.4～6.0 mass parts.
PTP of the present invention with or blister package with in sheet material, the mass ratio of above-mentioned organic coloring pigment (a1) and above-mentioned dispersing agent (a2) ((a1)/(a2)) preferably 30/70～75/25.
PTP of the present invention uses or blister package is used in sheet material, and above-mentioned resinous principle (B) is preferably esters resin or olefine kind resin.
PTP of the present invention uses or blister package is used in sheet material, the preferably stacked anti-layer that oozes out that contains at least a kind of resin that is selected from polypropylene, polyethylene and polychlorotrifluoroethylene in one or two sides.
Pharmaceuticals of the present invention packaging pack and is characterised in that with blister package with PTP or pharmaceuticals, by above-mentioned any one record for the PTP that packs pharmaceuticals with or blister package sheet forming form.
Manufacture pharmaceuticals of the present invention packaging is packed and is characterised in that by the method for blister package with PTP or pharmaceuticals, organic coloring pigment (a1) and the dispersing agent (a2) that number-average molecular weight is 100～3000 of the mean grain size with 20～400nm are mixed, prepared composition (A), mentioned component (A) is scattered in the resin combination in resinous principle (B) by preparation, the PTP that above-mentioned resin combination is configured as for packing pharmaceuticals uses or blister package sheet material, use above-mentioned sheet material, manufacturing pharmaceuticals packaging packs and uses blister package with PTP or pharmaceuticals.
The effect of invention
PTP of the present invention uses or blister package sheet material, in contained organic coloring pigment can be brought into play good dispersiveness (the concentrated existence of the organic coloring pigment in sheet material is few) in this sheet material, can reduce the generation of oozing out (or this does not occur ooze out) of organic coloring pigment.
In addition, due to this good dispersiveness, therefore in the time manufacturing PTP or blister package, can obtain the good formability of performance, and there is PTP or the blister package of covering, can bring into play on the whole good UV shielding scattering, the ultraviolet effect of absorption in the situation that at organic coloring pigment.
Detailed description of the invention
Below, PTP of the present invention is used or sheet material, PTP or blister package for blister package, and the manufacture method of PTP or blister package is elaborated.
[PTP uses or blister package sheet material]
PTP of the present invention uses or blister package sheet material is suitable for manufacturing for packing PTP or the blister package sheet material of pharmaceuticals, as ingredient, the organic coloring pigment (a1) and the number-average molecular weight that contain the mean grain size with 20～400nm are 100～3, the composition (A) that 000 dispersing agent (a2) mixes, and resinous principle (B).
Here, PTP use or blister package sheet material refer to the sheet material for the PTP that is shaped (Press-through pack) or blister package (being suitable for packing PTP or the blister package sheet material (pharmaceuticals are packed with PTP or pharmaceuticals and packed and use blister package sheet material) of pharmaceuticals).
In addition, in following record, use sheet material referred to as " sheet material of the present invention " PTP use of the present invention or blister package, organic coloring pigment (a1) and dispersing agent (a2) are also called to " (a1) composition ", and " (a2) composition ".
composition (A)
In sheet material of the present invention, contained composition (A) is that organic coloring pigment (a1), the number-average molecular weight with the mean grain size of 20～400nm is 100～3,000 dispersing agent (a2) and any composition (C) as described later mixes as required composition., composition (A) is the organic coloring pigment (a1) that is dispersed the coating of agent (a2) institute.
Above-mentioned (a1) composition is as long as having the organic tinting pigment of mean grain size of 20～400nm, be not particularly limited, from giving sheet material of the present invention and PTP therefrom or the blister package viewpoint with UV-preventing, preferably cover, the pigment of absorption and scatters ultraviolet (for example, 200～390nm).
As the concrete example of (a1) composition, can exemplify the organic pigments such as cyanine class, phenylethylene, phthalocyanines, Anthraquinones, purple cyclic ketones class, isoindoline ketone, quinophthalone class, quinacridine ketone, thioindigo class etc.
Consider from the difficulty and the safety and health that obtain, (a1) the preferred C.I. pigment yellow 147 (1 of composition, 1 '-[(6-phenyl-1, 3, 5-triazine-2, 4-bis-bases)-diimino] two-9, 10-amerantrone) (following formula (1)), C.I. pigment yellow 180 (2, 2'-[1, 2-ethylenebis (oxygen base-2, 1-phenylene azo)] two [N-(2, 3-dihydro-2-oxo--1H-benzimidazole-5-yl)-3-oxo-butyramide) (following formula (2)), C.I. pigment yellow 181 (N-[4-(amino carbonyl) phenyl]-4-[[1-[[2, 3-dihydro-2-oxo--1H-benzimidazole-5-yl) amino] carbonyl]-2-oxopropyl] azo] benzamide) (following formula (3)), or their compound.
[changing 1]
In addition, from improving light-proofness, safety and the transparent viewpoint of sheet material of the present invention and PTP therefrom or blister package, the preferred C.I. pigment yellow 180 of (a1) composition, C.I. paratonere 117 in above-mentioned.In addition, these compounds can be used alone, and also two or more can be used in combination.
In addition, (a1) mean grain size of composition is 20～400nm, but from improving the shading stability, safety of per unit area and the viewpoint of the transparency of sheet material of the present invention, preferably 250～350nm of this mean grain size.Here, this mean grain size refers to the mean grain size obtaining by following measuring method.
[measuring method of mean grain size]
Working sample: add (a1) composition in dispersed medium (ether), disperse with ultrasonic, it is attached on film (substrate), use transmission electron microscope (Jeol Ltd. (Japanese Electricity society) system) (a1) composition adhering on this substrate surface is taken to (multiple: 35,000 times), be determined at the value of the major diameter of the primary particle of (a1) composition of observing in the MIcrosope image obtaining, ask its aviation value.
When the mean grain size of (a1) composition is regulated in above-mentioned particular range, can use known method to carry out mechanicalness fragmentation, pulverizing to the organic coloring pigment of the particle diameter with the higher limit that exceedes above-mentioned particular range.As the object lesson of such method, can exemplify vibromill, vibromill, ball mill, turbine mill, planetary ball mill etc.
Above-mentioned dispersing agent (a2), as long as number-average molecular weight is not particularly limited at 100～3000, but as this dispersing agent (a2), from making the favorable dispersibility of (a1) composition film of the present invention and safe viewpoint, preferred number average molecular weight is at olefine kind resin (polyethylene, polypropylene, polybutene, ethylene-propylene copolymer, ethylene-butene copolymer etc.) of 100～3000 etc.In addition, various olefine kind resins can be used alone, and also two or more can be used in combination.
(a2) number-average molecular weight of composition is 100～3000.(a2) composition is owing to having such mol wt, therefore has appropriate viscosity (for example, 140 DEG C at viscosity be 5～500mPas).For this reason, if mixed with (a1) composition, the surface of (a1) composition is by the coating of (a2) composition, and (a1) aggegation between composition reduces, and in film, the dispersiveness of (a1) composition becomes good.
From making the dispersiveness of (a1) composition film of the present invention become better and safe viewpoint, this number-average molecular weight preferably 1500～2000.
In addition, (a2) number-average molecular weight of composition refers to, according to following condition determination with vapour pressure soak into platen press measure and number-average molecular weight.
[measuring method of number-average molecular weight]
Working sample: (a2) composition
Measuring method: vapour pressure is soaked into platen press
Measure machine: vapour pressure is soaked into and pressed meter K-7000 (Knoll Inc. (KNAUER society) system)
Composition (A) is that above-mentioned (a1) composition, (a2) composition and any composition (C) as required mix, and can pass through the known mixed method preparation such as V-type blender, ball grinding mill.
Organic coloring pigment and the dispersing agent of higher limit of specific average particle size range will be exceeded, with together with any composition (C) as required, when using mechanicalness pulverizing, the mixed methods such as vibromill, vibromill, ball mill, turbine mill, planetary ball mill to mix, (the mean grain size of organic coloring pigment is adjusted to particular range, prepare with (a1) with (a2)), prepared composition (A).
(a1) and mass ratio (mixture ratio (a2) in composition (A), (a1)/(a2)) can take to be worth arbitrarily, but from improving the viewpoint of the transparency, light-proofness and safety of the dispersiveness of (a1) composition film of the present invention, film of the present invention, this mass ratio preferably 30/70～75/25, more preferably 40/60～50/50.
In addition, sheet material of the present invention is from making the better viewpoint of dispersiveness, the transparency, light-proofness and safety, with respect to the following resinous principle (B) of 100 mass parts, preferably contain the composition (A) of the amount of 0.4～6.0 mass parts, more preferably contain 2.0～5.0 mass parts.
resinous principle (B)
Contained resinous principle (B) in sheet material of the present invention, as long as known, for PTP with or the resin of blister package sheet material be not particularly limited.As such resin, for example can exemplify the esters resin such as polyethylene terephthalate, PEN (polyester), the olefine kind resins such as polyethylene, polypropylene, polybutene, ethylene-propylene copolymer, ethylene-butene copolymer, polystyrene, polyamide, polyvinylchloride, polycarbonate, polyacrylinitrile, polyimide etc.In addition, these can be used alone, and also two or more can be used in combination.
Wherein, from improving viewpoint, resinous principle (B) preferred alkenes resinoid or the esters resin (polyester) of dispersiveness, the transparency that improves sheet material of the present invention, light-proofness and safety of (a1) composition sheet material of the present invention.
In addition, the number-average molecular weight of above-mentioned olefine kind resin or esters resin is for example 50,000～180,000 (with gel permeation chromatography).
composition (C) arbitrarily
Sheet material of the present invention can contain (a1) composition, (a2) composition and resinous principle (B) composition (composition (C) arbitrarily) in addition as required.
Here, arbitrarily composition (C) can be included in composition (A) (together with composition with (a1) composition and (a2), (a1) composition can be mixed with to composition (A) with any composition (C) together with (a2) composition) in, or be included in resinous principle (B) (, composition (A) and resinous principle (B) mix with any composition (C) together, for the preparation of the resin combination that forms sheet material of the present invention) in.
As any composition (C), for example can exemplify the stabilizers such as antioxidant, heat stabilizer, fast light stabilizer, ultraviolet scattering diluent except (a1) composition, ultraviolet absorbent except (a1) composition, inorganic pigment, antistatic agent, lubricant, plasticizer etc.Especially,, in order to obtain PTP or the blister package that the transparency is good, preferably admix antioxidant.As antioxidant, for example, can exemplify phenol antioxidant, Phosphorus antioxidant, sulphur class antioxidant etc.
pTP uses or blister package sheet material, and PTP or blister package
PTP of the present invention with or blister package sheet material be by mentioned component (A) and resinous principle (B) and composition as required (C) dispersion and must resin combination, be configured as by known gimmicks such as such as melt-shaping methods the sheet material that sheet obtains.
In addition, sheet material of the present invention, can be individual layer, also can be as required in one or two sides barrier layer for gases, gas-absorbing layer, damp course, light shield layer, the anti-layers (multi-layered type sheet material) such as layer that ooze out such as stacked oxygen barrier layers.Wherein, (a1) composition or the composition (C) of trace easily ooze out from sheet material of the present invention, from the viewpoint that can prevent from well oozing out, sheet material of the present invention preferably folds layer by layer as anti-oozing out the layer (multi-layered type sheet material) that contains at least a kind of resin that is selected from polypropylene, polyethylene and polychlorotrifluoroethylene in one or two sides.
In addition, in the one or two sides of sheet material of the present invention, in stacked when layer as above, can be used known laminating method.For example, sheet material of the present invention can be by will form the overlapping rear thermal welding of sheet material of each layer in one or two sides, or make to form sheet material Jie of each layer and paste manufacture by cement layer etc. and form.Here, in order to make the adaptation of sheet material of the present invention and above-mentioned each layer good, can, on two sides or either party's surface, implement corona treatment, low-temperature plasma processing, Ions Bombardment processing as pre-processing, also can further carry out chemical treatment, solvent processing.
Then, can be with co-extrusion molding methods such as multilayer T modulus method or multilayer inflation methods, the casting methods such as extrusion coated, dry type are compound, heat lamination, wet type flow coat method or dry type flow coat method, the multi-layer sheet forming process that rolling process etc. are general, to the resin combination that contains composition (A) and resinous principle (B), composition (C) as required with form the resin combination of each layer and form.
The thickness (being gross thickness in the situation of multi-layered type) of sheet material of the present invention is generally 150 μ m～400 μ m, the preferably scope of 180 μ m～350 μ m.If there is such thickness, can manufacture the good PTP of formability or blister package by sheet material of the present invention.
PTP of the present invention or blister package use above-mentioned PTP with or blister package sheet material manufacture.Such PTP or blister package are owing to having brought into play on the whole good UV shielding, be difficult to ooze out, thereby be suitable for the contents such as packaged food, medicine food or the medicine of ultraviolet ray deteriorated (variable color, rotten) (especially easily because of).
There is no particular limitation to manufacture the method for PTP or blister package by sheet material of the present invention, for example, in sheet surface, form vallecular cavity with known manufacturing process, in each vallecular cavity, load content, the joining sheet material surface and leakproofing material (cover) make the content sealing of filling, manufacture PTP or blister package.
Here, in sheet surface of the present invention, form the method for vallecular cavity, particularly can exemplify as follows.
Add the empty forming process of hot pressing: PTP use or blister package sheet material are clipped in to the counterdie in the hole with supply high temperature, high pressure draft and have between the patrix of recess of vallecular cavity shape, in the thermoplastic method of supplying with air-flow formation vallecular cavity simultaneously
Preheat the empty forming process of flat pressure: by PTP with or blister package with after sheet material thermoplastic, be clipped in and there is the counterdie in the hole of supplying with high pressure draft and have between the patrix of recess of vallecular cavity shape, supply with air-flow and form the method for vallecular cavity
Drum-type vacuum forming method: by PTP with or the thermoplastic of blister package sheet material heating drum part after, this recess of drum of recess with vallecular cavity shape is vacuumized to the method for shaping vallecular cavity
Pin type forming process: by the method for carrying out crimping with the male and female mold of vallecular cavity shape after PTP use or the thermoplastic of blister package sheet material
Preheat the empty forming process of the auxiliary pressure of stopper (Japanese: プ ラ グ): by after PTP use or the thermoplastic of blister package sheet material, be clipped in and there is the counterdie in the hole of supplying with high pressure draft and have between the patrix of recess of vallecular cavity shape, supply with air-flow and form vallecular cavity, and in the time being shaped, make the stopper that protrudes shape rise and decline with the method for assist formation
Film of the present invention, is not only difficult for causing cob webbing by vacuum forming method, by pressing empty forming process to be also difficult for causing cob webbing, therefore can or preheat the auxiliary isobaric empty forming process of empty forming process of pressing of stopper with the empty forming process of flat pressure and be shaped.In addition, the shape of the vallecular cavity portion of blister package of the present invention, size, the degree of depth, number, arrangement etc. can suitably be selected according to the shape of packed article or purposes.
In addition,, owing to can sealing by heat seal (adding thermal bonding) content of filling, therefore as leakproofing material (cover), preferably there is the material of heat sealability resin bed.Heat sealability resin bed is not particularly limited as long as the layer that carries out welding with the surface of the sheet material of the present invention of filling content when the heat seal, for example can exemplify the layer that contains one kind or two or more following compound: Low Density Polyethylene (LDPE), medium density polyethylene (MDPE), high density polyethylene (HDPE) (HDPE), wire Low Density Polyethylene (LLDPE), ethylene vinyl acetate co-polymer (EVA), polypropylene (PP), ethylene acrylic co-polymer (EAA), ethylene methacrylic acid co-polymer (EMA), ethylene methyl acrylate co-polymer (EMAA), ethylene ethyl acrylate co-polymer (EEA), ethylene methacrylic acid methyl esters co-polymer (EMMA), ionomer (IO) etc.
In addition, leakproofing material (cover), from the good viewpoint of gas barrier, preferably has the material of the metal evaporation retes such as aluminium lamination or metal foil layer.
Embodiment
Below, exemplify embodiment the present invention is specifically described, but the present invention is not limited to this.
The organic coloring pigment and the dispersing agent that in the present embodiment, use are as follows.
(1) yellow uitramarine powder: the pigment of the mean grain size with 320nm that C.I. pigment yellow 180 (Clariant Amada Co., Ltd. (Network ラ リ ア Application ト ジ ャ パ Application Co., Ltd.) system, trade name " PV Fast Yellow HG ") pulverizing is obtained.
Above-mentioned mean grain size is in dispersed medium (ether), to add C.I. pigment yellow 180, disperse with ultrasonic, it is attached on film (substrate), use transmission electron microscope (Jeol Ltd.'s system) to take (multiple: 35000 times) to the C.I. pigment yellow 180 adhering on this substrate surface, the value of the major diameter of the primary particle of the C.I. pigment yellow 180 of observing in the MIcrosope image that mensuration obtains, ask its aviation value, be mean grain size.
(2) Tissuemat E: Tissuemat E (Honeywell Inc. (Honeywell society) system, trade name " A-C6A " number-average molecular weight: viscosity at 2000,140 DEG C: 400cps)
In addition, the condition determination of the viscosity at the number-average molecular weight of Tissuemat E and 140 DEG C is as follows.
[number-average molecular weight]
Working sample: above-mentioned Tissuemat E
Measuring method: vapour pressure is soaked into platen press
Sensing equipment: vapour pressure is soaked into and pressed meter K-7000 (Knoll Inc.'s system)
[mensuration of viscosity]
The viscosity of above-mentioned Tissuemat E is by Brookfield viscometer, under No. 4 rotors, 60rpm, the condition of 60 seconds, 140 DEG C, measures.
[manufacture of sheet material for test]
" yellow uitramarine powder " (tinting pigment (a1)) and " Tissuemat E " (dispersing agent (a2)) are mixed to prepared composition (A1) and composition (A2) with the represented proportion of composing of following table 1.
[table 1]
Table 1
※ (a1) and (a2) add up to 100 quality %.
Then, based on kind and the ratio of the represented composition of table 2, composition A1 or composition A2 are added in the polypropylene of melting at approximately 200 DEG C, use two spiral shells to mediate extrusion presss and mix, obtain melting resin combination.
Use the non-ventilation of 15mm (Japanese: ノ Application ベ Application ト) single shaft extrusion press, this equipment possesses following part: for dropping into the funnel of resin, inflator, for heating the temperature booster of inflator, be arranged on the screw rod (full flighted screw (L/D=23)) in inflator, for extruding in the resin heating and melting that makes to drop into funnel, as the electrical motor (1.5KW) of the rotating power source of screw rod, be arranged on the mould of the front end (molten resin is extruded the part outside equipment) of inflator.Metal gauze (500 orders, Ishikawa metal gauze Co., Ltd. (Shi Chuanjin Net Co., Ltd.) system, " IKSCREEN " (registered trade mark (RTM)) Monotype) is set between the mould of this extrusion press in inflator and inflator.
The resin combination 1kg obtaining is put in the funnel of extruder, make the rotative speed rotation of screw rod with 150rpm, make molten resin composite by above-mentioned metal gauze, extrude continuously from mould, until resin combination is all extruded.Here start extrusion resin composite and resin combination is all extruded from mould with Visual Confirmation from mould.
In addition, follow the rotation of screw rod, to the molten resin in inflator along the moving direction of resin exert pressure (being set to the direction from screw rod to mould).
Herein, at the above-mentioned pressure (P when starting extrusion resin composite from mould
o) measure after, above-mentioned pressure (P when resin combination is all extruded from mould
1) measure.
Force value (P based on obtaining
oand P
1) and following formula 1, calculate the poor Δ P of rising of pressure
othe Δ P that use calculates and following metewand, evaluate dispersiveness.In addition above-mentioned " P,
1" and following " P
0" unit be MPa.
[several 1] Δ P=P
1-P
0
[metewand]
Zero: the value of Δ P is below 3.
×: the value of Δ P exceedes 3.In resin combination the dispersiveness of contained tinting pigment bad, due to tinting pigment aggegation each other, or in resin combination tinting pigment concentrate exist, the value of Δ P is larger.On the other hand, in resin combination, the favorable dispersibility of contained tinting pigment, because tinting pigment is difficult to aggegation each other, or in resin combination, tinting pigment disperses equably, and the value of Δ P is less.In addition,, in each embodiment, Δ P is in the scope of 0.2～0.7MPa.
Further, the resin combination that obtains is used to Multi layer extrusion machine, obtain being configured as stacked polypropylene layer (the test sheet material of the sheet of thickness 30 μ thickness 250 μ m m) on two sides.The test obtaining is cut into 10mm × 30mm size with sheet material, use UV visual spectrophotometer (V-560, Japan Spectroscopy Corporation (Japan Spectroscopy Corporation) system) measure the light transmittance (%) of wavelength 220～420nm, evaluate UV shielding based on following metewand.
[metewand] zero: light transmittance less than 10%.
×: light transmittance is more than 10%.
[table 2]
[table 2]
※ tests contain proportional (the quality %) while being 100 quality % with sheet material
If employing the present invention, when the good dispersion (the concentrated existence of the organic coloring pigment in sheet material is few) that can bring into play organic coloring pigment can be provided, can reduce the sheet material for be shaped PTP or blister package that oozes out generation (or this does not occur ooze out) (PTP with or blister package sheet material) of organic coloring pigment.
In addition, if employing the present invention, in the time manufacturing PTP or blister package, can provide performance good formability, and there is PTP or the blister package of covering, bringing into play on the whole good UV shielding scattering, the ultraviolet effect of absorption in the situation that at organic coloring pigment.
Above, describe the present invention with reference to embodiment, but the present invention is not subject to above-mentioned restriction.Formation of the present invention or detailed technology content can be carried out the intelligible various changes of those skilled in the art in scope of invention.
The application requires the Japanese patent application laid based on filing an application on December 7th, 2011 to be willing to the preceence of 2011-268067, quotes its whole disclosure at this.
The possibility of utilizing in industry
The present invention when being applicable to bring into play organic coloring pigment good dispersed, can reduce organic coloring pigment the generation of oozing out, for packing the sheet material of pharmaceuticals, thereby can be used for PTP or blister package.
Claims (7)
- One kind for pack pharmaceuticals, PTP with or blister package sheet material, it is characterized in that, the composition (A) that the dispersing agent (a2) that the organic coloring pigment (a1) that contains the mean grain size with 20～400nm and number-average molecular weight are 100～3000 mixes, and resinous principle (B).
- As claimed in claim 1 for pack pharmaceuticals, PTP with or blister package sheet material, it is characterized in that, with respect to the described resinous principle (B) of 100 mass parts, the composition (A) of the amount that contains 0.4～6.0 mass parts.
- As claimed in claim 1 or 2 for pack pharmaceuticals, PTP with or blister package sheet material, it is characterized in that, the mass ratio of described organic coloring pigment (a1) and described dispersing agent (a2), i.e. (a1)/(a2) is 30/70～75/25.
- As described in any one in claim 1～3 for pack pharmaceuticals, PTP with or blister package sheet material, it is characterized in that, described resinous principle (B) is esters resin or olefine kind resin.
- As described in any one in claim 1～4 for pack pharmaceuticals, PTP with or blister package sheet material, it is characterized in that, stackedly in one or two sides contain at least a kind of resin anti-that is selected from polypropylene, polyethylene and polychlorotrifluoroethylene and ooze out layer and form.
- 6. pharmaceuticals packagings pack a use blister package with PTP or pharmaceuticals, it is characterized in that, by described in any one in claim 1～5 for pack pharmaceuticals, PTP with or blister package sheet forming form.
- 7. use described sheet material to manufacture pharmaceuticals packaging PTP or pharmaceuticals and pack the method with blister package, it is characterized in that,Be that 100～3,000 dispersing agent (a2) mixes by thering is the organic coloring pigment (a1) of mean grain size of 20～400nm and number-average molecular weight, prepared composition (A),Described composition (A) is scattered in resinous principle (B) and prepares resin combination,By described resin combination be configured as PTP for packing pharmaceuticals with or blister package sheet material.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011-268067 | 2011-12-07 | ||
| JP2011268067A JP5892776B2 (en) | 2011-12-07 | 2011-12-07 | PTP or blister pack sheet for packaging pharmaceutical products, PTP for pharmaceutical packaging or blister pack for pharmaceutical packaging using the same, and method for producing PTP for pharmaceutical packaging or blister pack for pharmaceutical packaging |
| PCT/JP2012/081236 WO2013084834A1 (en) | 2011-12-07 | 2012-12-03 | Ptp or blister package sheet for packaging pharmaceutical product, ptp or blister package for packaging pharmaceutical product using same, and method for producing ptp or blister package for packaging pharmaceutical product |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103974883A true CN103974883A (en) | 2014-08-06 |
Family
ID=48574201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280059892.1A Pending CN103974883A (en) | 2011-12-07 | 2012-12-03 | Ptp or blister package sheet for packaging pharmaceutical product, ptp or blister package for packaging pharmaceutical product using same, and method for producing ptp or blister package for packaging pharmaceutical product |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP5892776B2 (en) |
| CN (1) | CN103974883A (en) |
| TW (1) | TWI592302B (en) |
| WO (1) | WO2013084834A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016098713A1 (en) * | 2014-12-16 | 2016-06-23 | 横浜ゴム株式会社 | Ultraviolet radiation-curable resin composition, and laminate |
| JP6564569B2 (en) * | 2014-12-26 | 2019-08-21 | 大成化工株式会社 | Polyvinyl chloride sheet for pharmaceutical packaging |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08193149A (en) * | 1995-01-13 | 1996-07-30 | Dainichiseika Color & Chem Mfg Co Ltd | Colored resin composition for transfusion bag |
| JP2000178361A (en) * | 1998-12-14 | 2000-06-27 | Dainichiseika Color & Chem Mfg Co Ltd | Resin masterbatch for coloring |
| JP2000289139A (en) * | 1999-04-12 | 2000-10-17 | Fujimori Kogyo Co Ltd | Blister bottom material |
| JP2008230112A (en) * | 2007-03-22 | 2008-10-02 | Toppan Printing Co Ltd | Laminated material and packaging body |
| CN101508368A (en) * | 2008-02-15 | 2009-08-19 | 艾尔坎技术及管理有限公司 | Cold-forming laminated material for bubble-cap basis parts |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3984757B2 (en) * | 1999-06-02 | 2007-10-03 | キヤノン株式会社 | Yellow toner, method for producing the toner, and image forming method |
| JP2006219548A (en) * | 2005-02-09 | 2006-08-24 | Sumitomo Bakelite Co Ltd | Colored polypropylene-based resin sheet and press-through-pack (ptp) container using the same |
-
2011
- 2011-12-07 JP JP2011268067A patent/JP5892776B2/en active Active
-
2012
- 2012-12-03 WO PCT/JP2012/081236 patent/WO2013084834A1/en active Application Filing
- 2012-12-03 CN CN201280059892.1A patent/CN103974883A/en active Pending
- 2012-12-05 TW TW101145592A patent/TWI592302B/en not_active IP Right Cessation
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08193149A (en) * | 1995-01-13 | 1996-07-30 | Dainichiseika Color & Chem Mfg Co Ltd | Colored resin composition for transfusion bag |
| JP2000178361A (en) * | 1998-12-14 | 2000-06-27 | Dainichiseika Color & Chem Mfg Co Ltd | Resin masterbatch for coloring |
| JP2000289139A (en) * | 1999-04-12 | 2000-10-17 | Fujimori Kogyo Co Ltd | Blister bottom material |
| JP2008230112A (en) * | 2007-03-22 | 2008-10-02 | Toppan Printing Co Ltd | Laminated material and packaging body |
| CN101508368A (en) * | 2008-02-15 | 2009-08-19 | 艾尔坎技术及管理有限公司 | Cold-forming laminated material for bubble-cap basis parts |
Also Published As
| Publication number | Publication date |
|---|---|
| JP5892776B2 (en) | 2016-03-23 |
| JP2013119412A (en) | 2013-06-17 |
| TWI592302B (en) | 2017-07-21 |
| TW201331032A (en) | 2013-08-01 |
| WO2013084834A1 (en) | 2013-06-13 |
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Application publication date: 20140806 |