CN103961805B - Tissue equivalent filler for cancer radiotherapy - Google Patents
Tissue equivalent filler for cancer radiotherapy Download PDFInfo
- Publication number
- CN103961805B CN103961805B CN201410137366.3A CN201410137366A CN103961805B CN 103961805 B CN103961805 B CN 103961805B CN 201410137366 A CN201410137366 A CN 201410137366A CN 103961805 B CN103961805 B CN 103961805B
- Authority
- CN
- China
- Prior art keywords
- filler
- tissue equivalent
- tissue
- radiation therapy
- equivalent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000945 filler Substances 0.000 title claims abstract description 51
- 238000001959 radiotherapy Methods 0.000 title claims abstract description 23
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 20
- 201000011510 cancer Diseases 0.000 title claims abstract description 18
- 229920001400 block copolymer Polymers 0.000 claims abstract description 10
- 239000000203 mixture Substances 0.000 claims abstract description 8
- 238000010438 heat treatment Methods 0.000 claims abstract description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 8
- WJAKXPUSJAKPHH-UHFFFAOYSA-N buta-1,3-diene;ethene;styrene Chemical compound C=C.C=CC=C.C=CC1=CC=CC=C1 WJAKXPUSJAKPHH-UHFFFAOYSA-N 0.000 claims description 8
- 239000010408 film Substances 0.000 claims description 8
- 229920002521 macromolecule Polymers 0.000 claims description 8
- 239000012528 membrane Substances 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 6
- 229910004298 SiO 2 Inorganic materials 0.000 claims description 4
- 239000000741 silica gel Substances 0.000 claims description 4
- 229910002027 silica gel Inorganic materials 0.000 claims description 4
- 239000004698 Polyethylene Substances 0.000 claims description 3
- -1 polyethylene Polymers 0.000 claims description 3
- 229920000573 polyethylene Polymers 0.000 claims description 3
- 229920006264 polyurethane film Polymers 0.000 claims description 3
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 2
- 239000004800 polyvinyl chloride Substances 0.000 claims description 2
- 239000010409 thin film Substances 0.000 claims description 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 3
- 230000005855 radiation Effects 0.000 abstract description 4
- 229940057995 liquid paraffin Drugs 0.000 abstract 1
- 238000011282 treatment Methods 0.000 description 6
- 206010006187 Breast cancer Diseases 0.000 description 3
- 208000026310 Breast neoplasm Diseases 0.000 description 3
- 238000001746 injection moulding Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000000465 moulding Methods 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 229920000428 triblock copolymer Polymers 0.000 description 3
- 238000002512 chemotherapy Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 239000012808 vapor phase Substances 0.000 description 2
- 241001466460 Alveolata Species 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- JSLMNNPQKHONFW-UHFFFAOYSA-N benzene naphthalene-1-carboxylic acid Chemical compound C1(=CC=CC2=CC=CC=C12)C(=O)O.C1=CC=CC=C1 JSLMNNPQKHONFW-UHFFFAOYSA-N 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001794 hormone therapy Methods 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
The invention discloses a tissue equivalent filler for cancer radiotherapy, which is prepared by mixing liquid paraffin and a styrene-ethylene-butadiene block copolymer to obtain a mixture, and heating and curing the mixture to obtain the tissue equivalent filler; the mass fraction of the styrene-ethylene-butadiene block copolymer in the mixture is 3-20%. The tissue equivalent filler can be in contact with the body of a patient in a fitting manner, no air bubbles exist between the tissue equivalent filler and the body of the patient, meanwhile, the tissue equivalent filler has better transparency, and a doctor can see marks on the body of the patient through the tissue equivalent filler, so that the accuracy and the uniformity of radiation dose are improved.
Description
Technical field
The present invention relates to a kind of medical instruments field, and in particular to a kind of tissue equivalent's filling for cancer radiation therapy
Thing.
Background technology
Up to the present, the treatment method of cancer includes operative treatment, radiotherapy, chemotherapy, hormone therapy, gene
Treatment and immunization therapy etc..Wherein, operative treatment, radiotherapy, chemotherapy has turned into Main Means.
Radiotherapy（Abbreviation radiotherapy）It is exactly to use high energy particle or ray, such as x-ray or gamma-rays are thin to kill cancer
Born of the same parents, so that treating cancer.Radiotherapy only has the history of decades, but development is very fast.It is auxiliary due to the use of super-pressure therapy apparatus
The improvement of assistant engineer's tool and the accumulation of experience, therapeutic effect are significantly improved, and the most important hand in treatment of cancer has been turned at present
One of section.
At present, about 70% cancer patient needs to use radiotherapy during treating cancer, there are about 40% cancer
Can be effected a radical cure with radiotherapy.Effect and status of the radiotherapy in oncotherapy become increasingly conspicuous.Radiotherapy has turned into treatment and has disliked
One of Main Means of property tumour.
In some cancers（Such as breast cancer）Patients During Radiotherapy in, for ensure dose of radiation it is accurate and uniform, to some because
The patient of missing is organized, it is necessary to use a kind of tissue equivalent's filler material to fill at tissue missing, makes radiation target dose
Distribution is more accurate and uniform.The conventional tissue equivalent's filler of clinic is paraffin wax, vaseline, special silica gel etc., and breast cancer is used
Tissue equivalent's filler typically uses special silica gel.
At present, the tissue equivalent's filler used in domestic hospitals is essentially all external import product, and is all deposited
In a universal shortcoming, contact of tissue equivalent's filler with patient body be not docile, so as in tissue equivalent's filler
There is bubble and patient body between, thus have influence on the accuracy and uniformity of dose of radiation.
The content of the invention
The present invention provides a kind of tissue equivalent's filler, snugly can be contacted with patient body, make itself and patient body it
Between do not exist bubble, and with the preferable transparency, can allow doctor that the mark on patient body is seen through tissue equivalent's filler
Note.
The invention discloses a kind of tissue equivalent's filler for cancer radiation therapy, by atoleine and styrene-
Ethylene-butadiene block copolymer is mixed to get mixture, is heating and curing and obtains described tissue equivalent's filler；The mixing
The mass fraction of styrene ethylene butadiene block copolymer is 3~20% in thing.
Styrene ethylene butadiene block copolymer is dispersed in liquid by the present invention using atoleine as carrier
In paraffin, tissue equivalent's filler surface prepared by cured shaping has appropriate viscosity and soft durometer, thus can be with docile
Be attached to the skin surface of patient, and ensure there is no bubble between tissue equivalent's filler and skin.
Preferably, also include dispersed SiO 2 powder in described mixture, for adjusting tissue equivalent
The density of filler, is required with meeting the different of client.
Preferably, the number-average molecular weight of described styrene ethylene butadiene block copolymer is 7~220,000, it is described
Mixture in styrene ethylene butadiene block copolymer mass fraction be 3~10%, more preferably 5%.
Preferably contacted to make the bottom surface of tissue equivalent's filler have with the body surface of patient, make its between patient body not
There is bubble, and with the preferable transparency, tissue equivalent's filler is shaped as terrace with edge or round platform, thickness is 2~
15mm。
Because the surface of the tissue equivalent's filler for preparing relatively is glued, doctor's operation and storage for convenience can be in the tissue
Has macromolecule membrane at least one surface of equivalent filler, when using, by only macromolecule membrane need to be taken off directly
Use.
Preferably, described macromolecule membrane is polyethylene film, polyvinyl chloride film, polyurethane film, poly- to benzene
Naphthalate film or silica gel thin film, the macromolecule membrane species that upper and lower surface has can be with identical, it is also possible to different.
Further preferably, the upper and lower surface of tissue equivalent's filler has macromolecule membrane simultaneously, and thickness is 0.01
~0.5 millimeter.
In for the Patients During Radiotherapy of breast cancer, in order that tissue equivalent's filler has with the body surface of patient preferably contact,
Shape by described tissue equivalent's filler is more preferably five terrace with edges；Further to improve the effect of radiotherapy, by thickness
Preferably 4~12mm.The top surface of five terrace with edges and bottom surface are pentagon, when using, pentagonal one side are placed along armpit,
So that whole tissue equivalent filler is snugly positioned over patient body-surface.
Compared with prior art, it is simply practical the beneficial effects of the invention are as follows design, it is easy to use.It can not only be solved
Existing tissue equivalent's filler is not docile with human contact, alveolate between patient body-surface and tissue equivalent's filler to lack
Point, and tissue equivalent's filler of the invention is more transparent, and doctor can be allowed to see on patient body through tissue equivalent's filler
Mark.
Brief description of the drawings
Fig. 1 is the outside drawing of tissue equivalent's filler prepared by embodiment 1.
Specific embodiment
Embodiment 1
By atoleine（36#Atoleine）, styrene ethylene butadiene triblock copolymer（Number-average molecular weight is 10
Ten thousand）And SiO 2 powder（Nanometer grade silica powder prepared by vapor phase method）In mass ratio it is 94:5:1 mixing, stirring is equal
Even rear injection molding, curing molding obtains tissue equivalent's filler at 190 DEG C.
Fig. 1 is the outside drawing of tissue equivalent's filler manufactured in the present embodiment, is five terrace with edge structures, and thickness is 5mm, top surface
It it is 135 ° with the angle between the wall of side, the outer surface of top surface is fitted with the polyurethane film of 0.02mm, and the outer surface of bottom surface is fitted with
The polyethylene film of 0.01mm.
Embodiment 2
By atoleine（36#Atoleine）, styrene ethylene butadiene triblock copolymer（Number-average molecular weight is 10
Ten thousand）And SiO 2 powder（Nanometer grade silica powder prepared by vapor phase method）In mass ratio it is 96:3:1 mixing, stirring is equal
Even rear injection molding, curing molding obtains tissue equivalent's filler at 190 DEG C.
Tissue equivalent's filler manufactured in the present embodiment is five terrace with edge structures, and thickness is 10mm, the folder between top surface and side wall
Angle is 135 °, and the outer surface of top surface is fitted with the pet film of 0.03mm.
Embodiment 3
By atoleine（36#Atoleine）With styrene ethylene butadiene triblock copolymer（Number-average molecular weight is
100000）In mass ratio it is 90:10 mixing, injection molding after stirring, curing molding obtains tissue equivalent's filler at 190 DEG C.
Claims (6)
1. a kind of tissue equivalent's filler for cancer radiation therapy, it is characterised in that by atoleine and styrene-second
Alkene-butadiene block copolymer is mixed to get mixture, is heating and curing and obtains described tissue equivalent's filler；
The number-average molecular weight of described styrene ethylene butadiene block copolymer is 7~220,000, benzene second in the mixture
The mass fraction of alkene-ethylene-butadiene block copolymer is 3~5%；
Tissue equivalent's filler is shaped as terrace with edge or round platform, and thickness is 2~15mm.
2. tissue equivalent's filler of cancer radiation therapy is used for as claimed in claim 1, it is characterised in that described mixing
Also include dispersed SiO 2 powder in thing.
3. tissue equivalent's filler of cancer radiation therapy is used for as claimed in claim 1, it is characterised in that described tissue etc.
Imitate and have macromolecule membrane at least one surface of filler, described macromolecule membrane is polyethylene film, polyvinyl chloride
Film, polyurethane film, pet film or silica gel thin film.
4. the tissue equivalent's filler for cancer radiation therapy as described in claim 1 or 3, it is characterised in that described group
That knits equivalent filler is shaped as five terrace with edges.
5. tissue equivalent's filler of cancer radiation therapy is used for as claimed in claim 4, it is characterised in that described tissue etc.
The thickness for imitating filler is 4~12mm.
6. tissue equivalent's filler of cancer radiation therapy is used for as claimed in claim 5, it is characterised in that described tissue etc.
Has macromolecule membrane simultaneously in the upper and lower surface for imitating filler.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410137366.3A CN103961805B (en) | 2014-04-04 | 2014-04-04 | Tissue equivalent filler for cancer radiotherapy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410137366.3A CN103961805B (en) | 2014-04-04 | 2014-04-04 | Tissue equivalent filler for cancer radiotherapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103961805A CN103961805A (en) | 2014-08-06 |
| CN103961805B true CN103961805B (en) | 2017-06-20 |
Family
ID=51232101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410137366.3A Active CN103961805B (en) | 2014-04-04 | 2014-04-04 | Tissue equivalent filler for cancer radiotherapy |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103961805B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109705806B (en) * | 2018-12-27 | 2020-12-15 | 杭州恒煜医疗科技有限公司 | Production method of tissue compensation glue for cancer radiotherapy |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0088932A1 (en) * | 1982-03-16 | 1983-09-21 | National Starch and Chemical Corporation | Heat resistant hot melt adhesives |
| CN102372893A (en) * | 2010-08-13 | 2012-03-14 | 上海锦湖日丽塑料有限公司 | Styrenic thermoplastic elastomer composition and preparation method thereof |
| CN102772417A (en) * | 2012-07-24 | 2012-11-14 | 上海现代药物制剂工程研究中心有限公司 | Period effect percutaneous patch of self viscosity elastic body substrate containing testosterone and preparation method thereof |
-
2014
- 2014-04-04 CN CN201410137366.3A patent/CN103961805B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0088932A1 (en) * | 1982-03-16 | 1983-09-21 | National Starch and Chemical Corporation | Heat resistant hot melt adhesives |
| CN102372893A (en) * | 2010-08-13 | 2012-03-14 | 上海锦湖日丽塑料有限公司 | Styrenic thermoplastic elastomer composition and preparation method thereof |
| CN102772417A (en) * | 2012-07-24 | 2012-11-14 | 上海现代药物制剂工程研究中心有限公司 | Period effect percutaneous patch of self viscosity elastic body substrate containing testosterone and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 《良导热、形状保持相变蓄热材料的制备及性能》;肖敏,龚克成;《太阳能学报》;20011031;第22卷(第4期);全文 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103961805A (en) | 2014-08-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Vyas et al. | On bolus for megavoltage photon and electron radiation therapy | |
| CN105664377B (en) | A kind of personalization silica gel equivalent compensation body film and preparation method thereof | |
| CN106039598B (en) | Radiotherapy tissue equivalent indemnity and preparation method thereof | |
| BR112012030463A2 (en) | process for making a dry and stable hesostatic composition, method for dispensing a hemostatic composition to a target site on a patient's body, final finished container, method for providing a ready-to-use hemostatic composition, kit for administering a hemostatic composition, and granules thrombin-coated | |
| US8219354B2 (en) | Bolus for radiotherapy and method for determining the shape of such a bolus | |
| CN104758930A (en) | Preparation method of in-situ gel based on magnetic graphene oxide and application thereof | |
| Park et al. | Development and dosimetric assessment of a patient-specific elastic skin applicator for high-dose-rate brachytherapy | |
| CN103961805B (en) | Tissue equivalent filler for cancer radiotherapy | |
| CN205924729U (en) | A organize equivalent compensation arrangement for cancer radiation therapy | |
| CN107998447B (en) | Conformal radiotherapy tissue equivalent compensation glue and preparation method and application thereof | |
| Hideghéty et al. | A prospective study of supine versus prone positioning and whole-body thermoplastic mask fixation for craniospinal radiotherapy in adult patients | |
| CN209019794U (en) | A kind of radiotherapy indemnity orientation film | |
| Zhang et al. | Effective rat lung tumor model for stereotactic body radiation therapy | |
| Garden | Radiotherapy for head and neck cancers: indications and techniques | |
| US9669116B2 (en) | Water-equivalent phantom | |
| CN204319537U (en) | A kind of tissue equivalent's implant for cancer radiation therapy | |
| Dong et al. | Novel combination treatment for melanoma: FLASH radiotherapy and immunotherapy delivered by a radiopaque and radiation responsive hydrogel | |
| CN205068971U (en) | A phantom for evaluating belly CT image registration precision | |
| CN207152894U (en) | Tissue compensation glue | |
| CN214181487U (en) | Compensation mould for radiotherapy after breast cancer operation | |
| Szymanowski et al. | PO-0850: MRI-Linac: Effect of the magnetic field on the interaction cross sections | |
| WO2024011452A1 (en) | Method for preparing thin film and use of thin film | |
| CN113679958B (en) | Equivalent tissue compensator and preparation method thereof | |
| Zhang et al. | Application value of 3D-printed Bolus in radiotherapy after radical mastectomy | |
| Gunter et al. | Novel application of vinylpolysiloxane hearing aid impression mold as patient‐specific bolus for head and neck cancer radiotherapy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20190506 Address after: 317300 No. 8 Youyi Road, Baita Block, Xianju County Economic Development Zone, Taizhou City, Zhejiang Province Patentee after: XIANJU YOUYI MEDICAL EQUIPMENT Co.,Ltd. Address before: 310016 Room 601, Unit 5, Building No. 35, Caihe Road, Hangzhou City, Zhejiang Province Patentee before: Li Hongbo |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20220511 Address after: 317317 No. 8, Baoda block, Baita District, Xianju Economic Development Zone, Taizhou, Zhejiang Patentee after: Zhejiang Youyi Medical Equipment Co.,Ltd. Address before: 317300 No. 8 Youyi Road, Baita Block, Xianju County Economic Development Zone, Taizhou City, Zhejiang Province Patentee before: XIANJU YOUYI MEDICAL EQUIPMENT Co.,Ltd. |
|
| EE01 | Entry into force of recordation of patent licensing contract | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20140806 Assignee: Xianju Youyi Medical Device Sales Co.,Ltd. Assignor: Zhejiang Youyi Medical Equipment Co.,Ltd. Contract record no.: X2024330000094 Denomination of invention: A tissue equivalent filler for cancer radiotherapy Granted publication date: 20170620 License type: Common License Record date: 20240605 |