CN103961094B - Based on the multi-functional electroencephalogramdata data collector of hardware implementing Laplce technology - Google Patents
Based on the multi-functional electroencephalogramdata data collector of hardware implementing Laplce technology Download PDFInfo
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Abstract
The invention provides a kind of multi-functional electroencephalogramdata data collector based on hardware implementing Laplce technology, this electroencephalogramdata data collector realizes brain wave acquisition based on Laplce's technology and brain wave acquisition two kinds of functions on hardware, not only economical and practical, and process data speed is fast, the online processes and displays in real time of EEG signals can be realized; This electroencephalogramdata data collector can select the EEG signals gathering 0.01-1KHZ with the sample frequency of 500-5KHZ, widen the acquisition range of EEG signals, the EEG signals collected contains more abundant brain electrical acti information, for nerve information and medical research provide more abundant data accurately.The present invention also adopts dynamic DC compensation technology, improves the common mode rejection ratio of electroencephalogramdata data collector, realizes high-precision eeg signal acquisition.
Description
Technical field
The invention belongs to technical field of biological information, be specifically related to a kind of multi-functional electroencephalogramdata data collector based on hardware implementing Laplce technology.
Background technology
Electroencephalogramdata data collector (EEG) be a kind of can with high time resolution and the important foundation technology of Non-Invasive acquisition physiological brain pathological information, the spatial resolution of traditional electroencephalogramdata data collector is lower, distortion is comparatively serious, is difficult to the locus determining gathered EEG signals.In order to improve the spatial resolution of brain electricity, within 1975, Hjorth proposes the concept of surface laplacian value in the research of electroencephalogram, carries out eeg data process by the method for mathematics.Nunez improved Laplce's technology further in " NeocorticaldynamicsandhumanEEGrhythms.NewYorK:OxfordUniv ersityPress; 1995 " afterwards, propose to utilize spline method to carry out the estimation of surface laplacian, and be applied in the research of electroencephalogram.Although these two kinds of methods improve the spatial resolution of EEG signals to a certain extent, the signal that these two kinds of methods obtain contains more noise, reduces the signal to noise ratio of signal; And be all realize the application of Laplce's technology in electroencephalogramdata data collector by the method for mathematics, its data amount of calculation is quite large, needs data to be processed very complicated, causes processing speed slow, is unfavorable for real-time detection.
Li Gangs etc. propose to adopt special active electrode Laplce to be applied in brain electricity at " design of brain electricity active Laplacian electrodes, data acquisition and procession; 2006; 21 (4) ", although this method can improve the spatial resolution of brain electricity, decrease the complexity of date processing, but the making of special electrode not only increases cost, and the quality of electrode own is also limited by processing technology, and this electrode also only could use under given conditions simultaneously;
In addition, traditional electroencephalogramdata data collector also limits the amplification of electroencephalogramdata data collector due to the existence of measuring brain electricity hour offset voltage, thus affect the common mode rejection ratio of electroencephalogramdata data collector, make the signal institute Noise that collects comparatively large, comprehensively can not reflect the content of brain electrical acti.For addressing this problem, conventional way adds wave trap in rear end, although it further can suppress common-mode signal, but adding of wave trap not only increases cost, and cause instrument volume to increase, and increasing power consumption, the device more seriously newly added to be added to useful signal due to the noise self produced, thus the signal to noise ratio of the signal reduced.
So far, also do not realized by conventional hardware approach for the application of Laplce's technology in brain electricity, and for electroencephalogramdata data collector preamplifier because the existence of offset voltage limits the amplification of preamplifier, thus limit the problem that its common mode rejection ratio improves and also there is no effective solution.
Summary of the invention
For solving the problem, the present invention proposes a kind of multifunction high-precision electroencephalogramdata data collector based on hardware implementing Laplce technology, comprise silver/silver chloride acquisition electrode, based on Laplce's technology brain wave acquisition module, conventional brain wave acquisition module, brain electro-detection functional switch, the high-accuracy preamplifier of multichannel, frequency overlapped-resistable filter, common-mode signal extract circuit, DC offset voltage compensating circuit, 24 high-speed a/ds, digital processing unit, USB transmission control module, host computer (data receiver, process) and brains right leg drive input RL.
Described silver/silver chloride acquisition electrode is common silver chloride electrode; Describedly to be connected with brain electro-detection functional switch respectively with conventional brain wave acquisition module based on Laplce's technology brain wave acquisition module, described brain electro-detection functional switch comprises N and selects 1 electrical switch, 2 inputs, 4 MUX, is input to the high-accuracy preamplifier of multichannel for selecting according to the actual needs by from the EEG signals based on Laplce's technology brain wave acquisition module or conventional brain wave acquisition module; The high-accuracy preamplifier of described multichannel comprises operational amplifier one, operational amplifier two, preamplifier, adjustable resistance R1, adjustable resistance R2, for amplify by brain electro-detection functional switch select from the EEG signals based on Laplce's technology brain wave acquisition module or conventional brain wave acquisition module; The high-accuracy preamplifier of described multichannel is connected to frequency overlapped-resistable filter, and EEG signals is input to frequency overlapped-resistable filter after the high-accuracy preamplifier of multichannel amplifies; Described frequency overlapped-resistable filter is connected with 24 high-speed a/ds, the EEG signals exported from frequency overlapped-resistable filter is inputted 24 high-speed a/ds, brain electric analoging signal is converted to brain electricity digital signal by 24 high-speed a/ds under the control of digital processing unit, more excellent, the sample frequency that 24 high-speed a/ds realize 500-5KHZ can be configured by digital processing unit, described digital processing unit is connected with USB transmission control module, and brain electricity digital signal transfers to host computer (data receiver, process) by USB transmission control module.
Described DC offset voltage compensating circuit extracts the DC offset voltage amount that the high-accuracy preamplifier outfan of multichannel comprises, and feeds back to the reference edge of the high-accuracy preamplifier of multichannel; Described common-mode signal extracts circuit by extracting the common-mode signal of the high-accuracy preamplifier of multichannel and feeding back to the right leg drive input (RL) with brain.
Described DC offset voltage compensating circuit comprises resistance R3, resistance R4, resistance R5, resistance R6, electric capacity C1, electric capacity C2 and operational amplifier three, wherein resistance R3 one end is connected with the outfan of preamplifier, the R3 other end is connected with electric capacity C2 one end with resistance R4 one end respectively, the resistance R4 other end is connected to electric capacity C1 and operational amplifier three in-phase input end, the outfan of electric capacity C2 other end concatenation operation amplifier three, electric capacity C1 other end ground connection, access operational amplifier three inverting input after resistance R5 and resistance R6 connects, resistance R5 other end ground connection, the outfan of another termination operational amplifier three of resistance R6, then the outfan of operational amplifier three is connected to the input of 24 high-speed a/ds.
In the present invention, described amplifier is high accuracy preamplifier, and its common mode rejection ratio is at more than 110dB, and amplification is within 1000 times; Described frequency overlapped-resistable filter is low pass filter; Described digital processing unit is high-speed figure process chip DSP; Described 24 high-speed a/ds adopt bipolarity 24 high-speed a/d converters.
Beneficial effect of the present invention: electroencephalogramdata data collector provided by the invention realizes brain wave acquisition based on Laplce's technology and conventional brain wave acquisition two kinds of functions on hardware, not only economical and practical, and process data speed is fast, the online processes and displays in real time of EEG signals can be realized; This electroencephalogramdata data collector can select the EEG signals gathering 0.01-1KHZ with the sample frequency of 500-5KHZ, widen the acquisition range of signal, the EEG signals collected contains more abundant brain electrical acti information, for nerve information and medical research provide more abundant data accurately.The present invention also adopts dynamic DC compensation technology, improves the common mode rejection ratio of electroencephalogramdata data collector, realizes high-precision eeg signal acquisition.
Accompanying drawing explanation
Fig. 1 is the theory diagram of the multi-functional electroencephalogramdata data collector based on hardware implementing Laplce technology;
Fig. 2 is eeg signal acquisition schematic diagram;
Fig. 3 is the schematic diagram of dynamic DC offset circuit.
Detailed description of the invention
Below in conjunction with accompanying drawing, the present invention is described in further details,
As shown in Figure 1, the multi-functional electroencephalogramdata data collector based on hardware implementing Laplce technology of a kind of feature in conjunction with EEG signals provided by the invention and Laplce's know-why, comprise silver/silver chloride acquisition electrode (101), based on Laplce's technology brain wave acquisition module (102), conventional brain wave acquisition module (103), brain electro-detection functional switch (104), the high-accuracy preamplifier of multichannel (105), frequency overlapped-resistable filter (106), common-mode signal extracts circuit (107), DC offset voltage compensating circuit (108), 24 high-speed a/ds (109), digital processing unit (110), USB transmission control module (111) and host computer (112).This electroencephalogramdata data collector can not only carry out the high-quality collection of conventional brain electricity, and Laplce's technology can be realized within hardware.Here brain wave acquisition module (103) is the state of the art, is not described in detail.
Described silver/silver chloride acquisition electrode uses common silver chloride electrode, describedly to be connected with brain electro-detection functional switch (102) respectively with conventional brain wave acquisition module (103) based on Laplce's technology brain wave acquisition module (102), described brain electro-detection functional switch comprises N and selects 1 electrical switch, 2 inputs, 4 MUX, is input to the high-accuracy preamplifier of multichannel (105) for selecting according to the actual needs by from the EEG signals based on Laplce's technology brain wave acquisition module (102) or conventional brain wave acquisition module (103), the high-accuracy preamplifier of described multichannel comprises operational amplifier one, operational amplifier two, preamplifier, adjustable resistance R1 and adjustable resistance R2, for amplify by brain electro-detection functional switch select from based on the brain wave acquisition module of Laplce's technology or the EEG signals of conventional brain wave acquisition module, the high-accuracy preamplifier of described multichannel (105) is connected to frequency overlapped-resistable filter (106), and EEG signals is input to frequency overlapped-resistable filter (106) after the high-accuracy preamplifier of multichannel (105) amplifies, described frequency overlapped-resistable filter (106) is connected with 24 high-speed a/ds (109), and the cut-off frequency arranging frequency overlapped-resistable filter (106) is 1KHZ, the EEG signals exported from frequency overlapped-resistable filter (106) is inputted 24 high-speed a/ds (109), brain electric analoging signal is converted to brain electricity digital signal by 24 high-speed a/ds (109) under the control of digital processing unit (110), more excellent, the sample frequency that digital processing unit (110) configuration 24 high-speed a/ds (109) realize 500-5KHZ can be passed through, described digital processing unit (110) is connected with USB transmission control module (111), brain electricity digital signal transfers to host computer (112) by USB transmission control module (111).
Simultaneously by remove silver/silver chloride acquisition electrode (101) DC offset voltage in extraction signal, described DC offset voltage compensating circuit (108) extracts the DC offset voltage amount that multichannel high-accuracy preamplifier (105) outfan comprises, and feed back to the reference edge of the high-accuracy preamplifier of multichannel (105), realize the dynamic compensation of DC offset voltage, in addition in order to reduce the interference of common-mode signal to EEG signals, described common-mode signal extracts circuit (107) by extracting the common-mode signal of the high-accuracy preamplifier of multichannel (105) and feeding back to the RL of brain.
As shown in Figure 2, based on the brain wave acquisition of Laplce's technology or the eeg signal acquisition process of brain wave acquisition be: the electrode of drawing from scalp surface (201) accesses N respectively and selects 1 electrical switch (202) and MUX, preferably there are 2 input, 4 MUX (203), wherein from the electrode node of scalp surface (201), select the input pin of 1 electrical switch (202) to be connected respectively with N, for ease of describing, N is selected input pin called after 3,1,5,4,2 foot respectively of 1 electrical switch connection electrode, now need to input 1,3,5,7 pins of 4 MUX (203) with 2 from electrode node P1, P2, P3, P4 of scalp surface (201) corresponding connected, reference electrode (REF) from scalp surface (201) accesses MUX, 2 of preferred 2 inputs 4 MUX (203), 4, 6, 8 pins and 2 input 13 of 4 MUX (203), 14 feet realize brain wave acquisition based on Laplce's technology or conventional brain wave acquisition, by the in-phase input end (pin 3) selecting the EEG signals of 1 electrical switch (202) and 2 inputs, 4 MUX (203) to access operational amplifier one (204) and operational amplifier two (205) respectively from N, operational amplifier one (204) is directly connected with outfan (pin 1) with the inverting input (pin 2) of operational amplifier two (205), EEG signals accesses in-phase input end (pin 1) and the inverting input (pin 4) of preamplifier (206) respectively by the outfan (pin 1) of operational amplifier one (204) and operational amplifier two (205), between the pin 2 that adjustable resistance R1 and adjustable resistance R2 is connected on preamplifier (206) after connecting and pin 3, for regulating the amplification of EEG signals, the EEG signals RL_IN that adjustable resistance R1 and adjustable resistance R2 junction are drawn accesses common-mode signal in Fig. 1 and extracts the signal input part of circuit (107), the pin 6 of preamplifier (206) accesses the signal output part of DC offset voltage compensating circuit (108) in Fig. 1 simultaneously, EEG signals after amplification is accessed the input of frequency overlapped-resistable filter in Fig. 1 (106) and the input of DC offset voltage compensating circuit (108) by the pin 7 of preamplifier (206).
Fig. 3 is DC offset voltage compensating circuit, described DC offset voltage compensating circuit comprises resistance R3, resistance R4, resistance R5, resistance R6, electric capacity C1, electric capacity C2 and operational amplifier three (301), wherein resistance R3 one end is connected with the outfan (pin 7) of high accuracy preamplifier (206) in Fig. 2, the R3 other end is connected with electric capacity C2 one end with resistance R4 one end respectively, the other end of resistance R4 is connected to electric capacity C1 and operational amplifier three (301) in-phase input end (pin 3), the outfan (pin 1) of electric capacity C2 other end concatenation operation amplifier three (301), electric capacity C1 other end ground connection, access operational amplifier three (301) inverting input (pin 2) after resistance R5 and resistance R6 connects, resistance R5 other end ground connection, the outfan (pin 1) of another termination operational amplifier three (301) of resistance R6, they finally form second order Butterworth LPF, cut-off frequency is set to 0.01HZ, then the outfan (pin 1) of operational amplifier three (301) will be connected to the input of 24 high-speed a/ds (109) in Fig. 1.
In the present invention, described amplifier is high accuracy preamplifier, and require that its common mode rejection ratio is at more than 110dB, amplification is within 1000 times; Described frequency overlapped-resistable filter is low pass filter, and employing cut-off frequency is the second order butterworth filter of 1KHz; Described digital processing unit is high-speed figure process chip DSP; Described 24 high-speed a/ds adopt bipolarity 24 high-speed a/d converters.
A kind of multifunction high-precision electroencephalogramdata data collector based on hardware implementing Laplce technology provided by the invention, its specific works flow process is:
Eeg recording electrode (silver/silver chloride acquisition electrode (101)) is worn to brain, EEG signals is input to based on Laplce's technology brain wave acquisition module (102) and conventional brain wave acquisition module (103) by the silver/silver chloride acquisition electrode (101) being attached to scalp surface, then the EEG signals input high-accuracy preamplifier of multichannel (105) based on Laplce's technology brain wave acquisition module (102) or conventional brain wave acquisition module (103) is selected according to the actual requirements by brain Electricity Functional sense switch (104), realize the amplification of EEG signals and the suppression of common-mode noise, simultaneously in order to suppress common-mode signal further, extracting common-mode signal by the high-accuracy preamplifier of multichannel (105) and extracting circuit (107) through common-mode signal and common-mode signal amplified and feeds back to human body.In addition in order to improve the amplification of the high-accuracy preamplifier of multichannel (105), DC offset voltage is extracted and the high-accuracy preamplifier of the multichannel that inversely adds (105) by DC offset voltage compensating circuit (108); Through EEG signals input frequency overlapped-resistable filter (106) of the high-accuracy preamplifier of multichannel (105), the filtering to signal will be realized again; Then signal is inputted 24 high-speed a/ds (109), under the control of digital processing unit (110), by 24 high-speed a/ds (109), simulation EEG signals is converted to brain electricity digital signal, and brain electricity digital signal is transferred to host computer by USB controls transfer module (111), the display being carried out data by host computer (112) is stored.Here host computer carries out data receiver and process, and detailed process can be considered as the state of the art, is not described in detail.
In the present embodiment, silver/silver chloride acquisition electrode is connected with brain electro-detection functional switch through cable, can select according to actual needs to connect the brain wave acquisition based on Laplce's technology or brain wave acquisition, through the EEG signals input frequency overlapped-resistable filter that the high-accuracy preamplifier of multichannel amplifies, then under the control of digital processing unit, enter USB interface through 24 high-speed a/ds, USB interface is connected with computer (main frame); Described computer (main frame) is connected with mouse, keyboard, display apparatus simultaneously.Described USB interface adopts Universal USB 2.0 interface protocol.Described computer (main frame) is more than 500MHzPentium processor, the operating system of more than 256MB system RAM, more than 10GB hard disk, USB2.0 interface and windows7 or windowsvista.Described display is CRT monitor or liquid crystal display, and display screen is minimum is 14 inches.
Those of ordinary skill in the art will appreciate that, embodiment described here is to help reader understanding's principle of the present invention, should be understood to that protection scope of the present invention is not limited to so special statement and embodiment.Those of ordinary skill in the art can make various other various concrete distortion and combination of not departing from essence of the present invention according to these technology enlightenment disclosed by the invention, and these distortion and combination are still in protection scope of the present invention.
Claims (3)
1. based on the multi-functional electroencephalogramdata data collector of hardware implementing Laplce technology, it is characterized in that, comprise silver/silver chloride acquisition electrode, based on Laplce's technology brain wave acquisition module, conventional brain wave acquisition module, brain electro-detection functional switch, the high-accuracy preamplifier of multichannel, frequency overlapped-resistable filter, common-mode signal extract circuit, DC offset voltage compensating circuit, 24 high-speed a/ds, digital processing unit, USB transmission control module, host computer and brains right leg drive end RL
Described silver/silver chloride acquisition electrode is common silver chloride electrode; Describedly to be connected with brain electro-detection functional switch respectively with conventional brain wave acquisition module based on Laplce's technology brain wave acquisition module, described brain electro-detection functional switch comprises N and selects 1 electrical switch, 2 inputs, 4 MUX, is input to the high-accuracy preamplifier of multichannel for selecting according to the actual needs by from the EEG signals based on Laplce's technology brain wave acquisition module or conventional brain wave acquisition module; The high-accuracy preamplifier of described multichannel comprises operational amplifier one, operational amplifier two, preamplifier, adjustable resistance R1 and adjustable resistance R2, for amplify by brain electro-detection functional switch select from the EEG signals based on Laplce's technology brain wave acquisition module or conventional brain wave acquisition module; The high-accuracy preamplifier of described multichannel is connected to frequency overlapped-resistable filter, and EEG signals is input to frequency overlapped-resistable filter after the high-accuracy preamplifier of multichannel amplifies; Described frequency overlapped-resistable filter is connected with 24 high-speed a/ds, the EEG signals exported is input to 24 high-speed a/ds from frequency overlapped-resistable filter, and brain electric analoging signal is converted to brain electricity digital signal by 24 high-speed a/ds under the control of digital processing unit; Configure by digital processing unit the sample frequency that 24 high-speed a/ds realize 500-5KHZ, described digital processing unit is connected with USB transmission control module, and brain electricity digital signal transfers to host computer by USB transmission control module; Described DC offset voltage compensating circuit extracts the DC offset voltage amount that the high-accuracy preamplifier outfan of multichannel comprises, and feeds back to the reference edge of the high-accuracy preamplifier of multichannel; Described common-mode signal extracts circuit by extracting the common-mode signal of the high-accuracy preamplifier of multichannel and feeding back to the right leg drive end RL of brain.
2. the multi-functional electroencephalogramdata data collector based on hardware implementing Laplce technology according to claim 1, it is characterized in that, described DC offset voltage compensating circuit comprises resistance R3, resistance R4, resistance R5, resistance R6, electric capacity C1, electric capacity C2 and operational amplifier three, wherein resistance R3 one end is connected with the outfan of preamplifier, the other one end of R3 is connected with electric capacity C2 one end with resistance R4 one end respectively, the resistance R4 other end is connected to electric capacity C1 and operational amplifier three in-phase input end, the outfan of electric capacity C2 other end concatenation operation amplifier three, electric capacity C1 other end ground connection, access operational amplifier three inverting input after resistance R5 and resistance R6 connects, resistance R5 other end ground connection, the outfan of another termination operational amplifier three of resistance R6, then the outfan of operational amplifier three is connected to the input of 24 high-speed a/ds.
3. the multi-functional electroencephalogramdata data collector based on hardware implementing Laplce technology according to claim 2, it is characterized in that, described preamplifier is the high-precision instrument operational amplifier of low noise, and its common mode rejection ratio is at more than 110dB, and amplification is within 1000 times; Described frequency overlapped-resistable filter is low pass filter; Described digital processing unit is high-speed figure process chip DSP; Described 24 high-speed a/ds adopt bipolarity 24 high-speed a/d converters.
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| CN106725459A (en) * | 2017-01-05 | 2017-05-31 | 电子科技大学 | Eeg signal acquisition system |
| US10694964B2 (en) * | 2017-09-05 | 2020-06-30 | International Business Machines Corporation | Neural spike scanning for high-density implantable neural recording systems |
| CN111061150B (en) * | 2019-10-23 | 2020-11-27 | 南京大学 | Hardware implementation method of Laplace frequency response |
| CN116392144B (en) * | 2022-12-07 | 2023-11-24 | 天津大学 | Brain signal acquisition system, method and medium |
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