CN103960564A - Functional inulin tablet and preparation method thereof - Google Patents
Functional inulin tablet and preparation method thereof Download PDFInfo
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- CN103960564A CN103960564A CN201310044554.7A CN201310044554A CN103960564A CN 103960564 A CN103960564 A CN 103960564A CN 201310044554 A CN201310044554 A CN 201310044554A CN 103960564 A CN103960564 A CN 103960564A
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- inulin
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- 229920001202 Inulin Polymers 0.000 title claims abstract description 50
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 title claims abstract description 50
- 229940029339 inulin Drugs 0.000 title claims abstract description 50
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 238000002156 mixing Methods 0.000 claims abstract description 10
- 239000000314 lubricant Substances 0.000 claims abstract description 9
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 9
- 229920002472 Starch Polymers 0.000 claims description 15
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 15
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 15
- 235000010980 cellulose Nutrition 0.000 claims description 13
- 229920002678 cellulose Polymers 0.000 claims description 13
- 239000001913 cellulose Substances 0.000 claims description 13
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 11
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 11
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 11
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 11
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 10
- 235000019890 Amylum Nutrition 0.000 claims description 9
- 150000004676 glycans Chemical class 0.000 claims description 9
- -1 polyethylene pyrrolidone Polymers 0.000 claims description 9
- 229920001282 polysaccharide Polymers 0.000 claims description 9
- 239000005017 polysaccharide Substances 0.000 claims description 9
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 8
- 239000007884 disintegrant Substances 0.000 claims description 8
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 7
- 238000004132 cross linking Methods 0.000 claims description 7
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 7
- 239000011734 sodium Substances 0.000 claims description 6
- 229910052708 sodium Inorganic materials 0.000 claims description 6
- 239000008107 starch Substances 0.000 claims description 6
- 235000019698 starch Nutrition 0.000 claims description 6
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 5
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 5
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 5
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 5
- 239000008101 lactose Substances 0.000 claims description 5
- 239000000661 sodium alginate Substances 0.000 claims description 5
- 235000010413 sodium alginate Nutrition 0.000 claims description 5
- 229940005550 sodium alginate Drugs 0.000 claims description 5
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims description 4
- 229920002261 Corn starch Polymers 0.000 claims description 4
- 239000001856 Ethyl cellulose Substances 0.000 claims description 4
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 4
- 239000008120 corn starch Substances 0.000 claims description 4
- 229940099112 cornstarch Drugs 0.000 claims description 4
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 4
- 229920001249 ethyl cellulose Polymers 0.000 claims description 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 4
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 4
- 229920000609 methyl cellulose Polymers 0.000 claims description 4
- 239000001923 methylcellulose Substances 0.000 claims description 4
- 235000010981 methylcellulose Nutrition 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 4
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 2
- 235000013305 food Nutrition 0.000 abstract description 2
- 210000002784 stomach Anatomy 0.000 abstract description 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 238000007906 compression Methods 0.000 description 6
- 230000006835 compression Effects 0.000 description 6
- 239000002932 luster Substances 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 4
- 241000607142 Salmonella Species 0.000 description 4
- 241000607768 Shigella Species 0.000 description 4
- 241000191967 Staphylococcus aureus Species 0.000 description 4
- 244000052616 bacterial pathogen Species 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 4
- 238000009475 tablet pressing Methods 0.000 description 4
- 229920002785 Croscarmellose sodium Polymers 0.000 description 3
- 229940063834 carboxymethylcellulose sodium Drugs 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 229930091371 Fructose Natural products 0.000 description 2
- 239000005715 Fructose Substances 0.000 description 2
- 240000008892 Helianthus tuberosus Species 0.000 description 2
- 235000003230 Helianthus tuberosus Nutrition 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 239000011149 active material Substances 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008279 sol Substances 0.000 description 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- 241000186000 Bifidobacterium Species 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000021152 breakfast Nutrition 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- BJHIKXHVCXFQLS-UYFOZJQFSA-N fructose group Chemical group OCC(=O)[C@@H](O)[C@H](O)[C@H](O)CO BJHIKXHVCXFQLS-UYFOZJQFSA-N 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 150000004040 pyrrolidinones Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention belongs to the technical field of food processing, and especially relates to a functional inulin tablet using inulin as an active component, and a preparation method thereof. The functional inulin tablet is prepared by mixing 80-95wt% of the active component inulin with 1-10wt% of a lubricant, 1-10wt% of an excipient and 1-10wt% of a disintegrating agent, and tabletting. The preparation method comprises the following steps: mixing the above powdery raw materials in proportion, drying in a 50-60DEG C oven for 1-10h, and directly tabletting. The inulin tablet prepared in the invention has the advantages of smooth and complete surface, uniform color, and no splitting, loosening or sticking phenomenon, and has a disintegration time limit of 10min or less in the stomach.
Description
Technical field
The invention belongs to food processing technology field, especially relate to functional inulin sheet taking inulin as active component and preparation method thereof.
Background technology
Inulin has another name called synanthrin, stems from jerusalem artichoke piece root, is a kind of natural fructose polymer, and it is by being greater than 2-60 fructose units with β-1, the fructose compound that 2 glycosidic bonds connect.As a kind of natural soluble dietary fiber, inulin is hydrolyzed by hydrochloric acid in gastric juice hardly and digests, and fermented by a large amount of beneficial microbes in colon, especially there is the function of superpower propagation Bifidobacterium, thereby possess the health care of all multipair human bodies, as controlled blood fat, reduce blood sugar, improve function of intestinal canal, promoting mineral absorption.
Current inulin compressing tablet mainly contains three problems in process:
If the weight that A is every is excessive, although made inulin sheet has low fragility, is easy to produce top and splits phenomenon; In addition, because jerusalem artichoke sheet weight is excessive, required compression mold pressure is also large, can cause breaking-up to a certain degree to compression mold.
B, as heavy in chankings not too large, although made inulin sheet does not split phenomenon in top, is easy to loose sheet.
C, inulin in pressing process owing to being exposed in air, can be because easily water suction produces stickiness and cause inulin and easily stick on compression mold and make tablet imperfect or cracked.
Owing to having above problem, the inulin sheet of producing both at home and abroad at present mostly can not be satisfactory.As everyone knows, most active materials do not add added substance can not be compressed.For inulin, the present invention has tested multiple compression aids to these problems are eliminated under the prerequisite that retains useful characteristic.As we attempt with microcrystalline cellulose, amylum pregelatinisatum, compressibility polysaccharide, lactose, soluble poly vinyl pyrrolidone and are suitable for one or more in the powdery cellulose of compressing tablet and improve the forming ability of inulin, especially the use of microcrystalline cellulose and soluble poly vinyl pyrrolidone, is used for compressing tablet as filler and adhesive for a long time at pharmaceutical industry.
Compression aids requires to have mobility, cementitiousness well, and has high carrying capacity for the active material of difficulty compression.And the inulin tablet producing is hoped to have shorter disintegration time, the broken power of low fragility, high resistance, but these contradictions often between requiring.We wish that inulin sheet has good disintegration time limited under one's belt, need exactly it in intestines and stomach, can break fast to discharge rapidly active ingredient, and wish its low fragility, the broken power of high resistance to need exactly it to have cohesive and hardness well simultaneously.In order to solve this contradiction, we attempt improving its hardness with one or both in talcum powder or dolomol, improve its disintegration ability by one or more in cross-linking polyethylene pyrrolidone, carboxyrnethyl starch sodium, cross-linked carboxymethyl cellulose sodium.
Summary of the invention
The object of the present invention is to provide a kind of functional inulin sheet and preparation method thereof.
For achieving the above object, the technical solution used in the present invention is:
A kind of functional inulin sheet, functional inulin sheet is the active component inulin of 80-95% weight by weight percentage, the lubricant of 1-10% weight, the disintegrant of the excipient of 1-10% weight and 1-10% weight makes through mixed pressuring plate.
Described lubricant is one or both the mixing in dolomol, polyethylene glycol and talcum powder.
Described excipient is one or more in microcrystalline cellulose, amylum pregelatinisatum, compressibility polysaccharide, lactose, soluble poly vinyl pyrrolidone and the powdery cellulose that is suitable for compressing tablet.
Described disintegrant is one or more in cross-linking polyethylene pyrrolidone, carboxyrnethyl starch sodium, Ac-Di-Sol.
Described microcrystalline cellulose is a kind of wherein 95% particle between 1-100 μ m and the cellulose of balance granular size between 10-70 μ m;
Described compressibility polysaccharide refers to sodium alginate and/or oligoisomaltose powder;
Described soluble poly vinyl pyrrolidone is the PVP that K value is 25-80;
Described amylum pregelatinisatum refers to cornstarch;
The described powdery cellulose that is suitable for compressing tablet refers to one or more in methylcellulose, Hydroxypropyl methylcellulose, sodium carboxymethylcellulose, ethyl cellulose.
A preparation method for functional inulin sheet, counts inulin 90-95% according to percentage by weight, lubricant 1-10%, and excipient 1-10%, disintegrant 1-10% is dried 1-10 hour direct tablet compressing after each material grinding is mixed in 50-60 DEG C of baking oven.
Described lubricant is one or both the mixing in dolomol, polyethylene glycol and talcum powder.
Described excipient is one or more in microcrystalline cellulose, amylum pregelatinisatum, compressibility polysaccharide, lactose, soluble poly vinyl pyrrolidone and the powdery cellulose that is suitable for compressing tablet.
Described disintegrant is one or more in cross-linking polyethylene pyrrolidone, carboxyrnethyl starch sodium, Ac-Di-Sol.
Described microcrystalline cellulose is a kind of wherein 95% particle between 1-100 μ m and the cellulose of balance granular size between 10-70 μ m;
Described compressibility polysaccharide refers to sodium alginate and/or oligoisomaltose powder;
Described soluble poly vinyl pyrrolidone is the PVP that K value is 25-80;
Described amylum pregelatinisatum refers to cornstarch;
The described powdery cellulose that is suitable for compressing tablet refers to one or more in methylcellulose, Hydroxypropyl methylcellulose, sodium carboxymethylcellulose, ethyl cellulose.
More preferably: after 95g inulin, 2g K30 PVP, 2g cross-linked carboxymethyl cellulose sodium, the grinding of 1g dolomol are mixed, in 60 DEG C of dry 3 hours direct tablet compressings, obtain functional inulin sheet.
Compared with prior art, the advantage that the present invention has has:
1, without sliver, loose sheet, glutinously rush phenomenon, appearance is complete bright and clean, color and luster is even, has suitable hardness and wearability.
2, disintegration ability improves to some extent, under one's belt disintegration time limited≤10min.
3, tablet good fluidity in compressing tablet process, can pressure strong, even if very low pressure also can obtain.
Detailed description of the invention
Embodiment 1:
Get inulin 96.6kg, talcum powder 1.2kg, the water-soluble polyethylene base pyrrolidones 1.2kg of 40K value, cross-linking polyethylene pyrrolidone 1kg pulverized 120 mesh sieves after mixing in Universalpulverizer, and in 80 ° of C baking ovens, dry 6h, uses Manual tablet pressing machine compressing tablet.
Every weight 0.3 ± 0.001g of the functional inulin sheet of above-mentioned gained, sheet weight average is even, and smooth in appearance is clean and tidy, color and luster is even, there is hardness and wearability well, friability≤0.65%, dissolution rate, release are greatly >=80%, be 9 ± 1min disintegration time limited, plumbous/(mg/Kg) not detect total number of bacteria/(cfu/ml)≤800, mould/(cfu/ml)≤20, yeast/(cfu/ml)≤20, pathogenic bacteria (salmonella, Shigella, staphylococcus aureus) do not detect.
Embodiment 2:
Get inulin 96.8kg, dolomol 1kg, microcrystalline cellulose 1.2kg, cross-linking polyethylene pyrrolidone 1kg pulverized 120 mesh sieves after mixing in Universalpulverizer, and in 70 ° of C baking ovens, dry 4h, uses Manual tablet pressing machine compressing tablet.
Every weight 0.3 ± 0.001g of the functional inulin sheet of above-mentioned gained, sheet weight average is even, and smooth in appearance is clean and tidy, color and luster is even, there is hardness and wearability well, friability≤0.65%, dissolution rate, release are greatly >=80%, be 9 ± 1min disintegration time limited, plumbous/(mg/Kg) not detect total number of bacteria/(cfu/ml)≤800, mould/(cfu/ml)≤20, yeast/(cfu/ml)≤20, pathogenic bacteria (salmonella, Shigella, staphylococcus aureus) do not detect.
Embodiment 3:
Get inulin 98kg, talcum powder 1.2kg, sodium alginate 0.8kg, sodium carboxymethyl starch 1kg pulverized 120 mesh sieves after mixing in Universalpulverizer, and in 70 ° of C baking ovens, dry 10h, uses Manual tablet pressing machine compressing tablet.
Every weight 0.3 ± 0.001g of the functional inulin sheet of above-mentioned gained, sheet weight average is even, and smooth in appearance is clean and tidy, color and luster is even, there is hardness and wearability well, friability≤0.65%, dissolution rate, release are greatly >=85%, be 9 ± 1min disintegration time limited, plumbous/(mg/Kg) not detect total number of bacteria/(cfu/ml)≤800, mould/(cfu/ml)≤20, yeast/(cfu/ml)≤20, pathogenic bacteria (salmonella, Shigella, staphylococcus aureus) do not detect.
Embodiment 4:
Get inulin 95.5kg, dolomol 1.5kg, oligomeric maltose 2kg, cross-linked carboxymethyl cellulose sodium 1kg pulverized 120 mesh sieves after mixing in Universalpulverizer, and in 80 ° of C baking ovens, dry 8h, uses Manual tablet pressing machine compressing tablet.
Every weight 0.3 ± 0.001g of the functional inulin sheet of above-mentioned gained, sheet weight average is even, and smooth in appearance is clean and tidy, color and luster is even, there is hardness and wearability well, friability≤0.65%, dissolution rate, release are greatly >=85%, be 10 ± 1min disintegration time limited, plumbous/(mg/Kg) not detect total number of bacteria/(cfu/ml)≤800, mould/(cfu/ml)≤20, yeast/(cfu/ml)≤20, pathogenic bacteria (salmonella, Shigella, staphylococcus aureus) do not detect.
Claims (10)
1. a functional inulin sheet, is characterized in that: functional inulin sheet is the active component inulin of 80-95% weight by weight percentage, the lubricant of 1-10% weight, and the disintegrant of the excipient of 1-10% weight and 1-10% weight makes through mixed pressuring plate.
2. by functional inulin sheet claimed in claim 1, it is characterized in that: described lubricant is one or both the mixing in dolomol, polyethylene glycol and talcum powder.
3. by functional inulin sheet claimed in claim 1, it is characterized in that: described excipient is one or more in microcrystalline cellulose, amylum pregelatinisatum, compressibility polysaccharide, lactose, soluble poly vinyl pyrrolidone and the powdery cellulose that is suitable for compressing tablet.
4. by functional inulin sheet claimed in claim 1, it is characterized in that: described disintegrant is one or more in cross-linking polyethylene pyrrolidone, carboxyrnethyl starch sodium, Ac-Di-Sol.
5. by functional inulin sheet claimed in claim 1, it is characterized in that: described microcrystalline cellulose is a kind of wherein 95% particle between 1-100 μ m and the cellulose of balance granular size between 10-70 μ m;
Described compressibility polysaccharide refers to sodium alginate and/or oligoisomaltose powder;
Described soluble poly vinyl pyrrolidone is the PVP that K value is 25-80;
Described amylum pregelatinisatum refers to cornstarch;
The described powdery cellulose that is suitable for compressing tablet refers to one or more in methylcellulose, Hydroxypropyl methylcellulose, sodium carboxymethylcellulose, ethyl cellulose.
6. the preparation method of a functional inulin sheet claimed in claim 1, it is characterized in that: count inulin 90-95% according to percentage by weight, lubricant 1-10%, excipient 1-10%, disintegrant 1-10% is dried 1-10 hour direct tablet compressing after each material grinding is mixed in 50-60 DEG C of baking oven.
7. by the preparation method of functional inulin sheet claimed in claim 6, it is characterized in that: described lubricant is one or both the mixing in dolomol, polyethylene glycol and talcum powder.
8. by the preparation method of functional inulin sheet claimed in claim 6, it is characterized in that: described excipient is one or more in microcrystalline cellulose, amylum pregelatinisatum, compressibility polysaccharide, lactose, soluble poly vinyl pyrrolidone and the powdery cellulose that is suitable for compressing tablet.
9. by the preparation method of functional inulin sheet claimed in claim 6, it is characterized in that: described disintegrant is one or more in cross-linking polyethylene pyrrolidone, carboxyrnethyl starch sodium, Ac-Di-Sol.
10. by the preparation method of functional inulin sheet claimed in claim 8, it is characterized in that: described microcrystalline cellulose is a kind of wherein 95% particle between 1-100 μ m and the cellulose of balance granular size between 10-70 μ m;
Described compressibility polysaccharide refers to sodium alginate and/or oligoisomaltose powder;
Described soluble poly vinyl pyrrolidone is the PVP that K value is 25-80;
Described amylum pregelatinisatum refers to cornstarch;
The described powdery cellulose that is suitable for compressing tablet refers to one or more in methylcellulose, Hydroxypropyl methylcellulose, sodium carboxymethylcellulose, ethyl cellulose.
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| CN201310044554.7A CN103960564A (en) | 2013-02-04 | 2013-02-04 | Functional inulin tablet and preparation method thereof |
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| CN201310044554.7A CN103960564A (en) | 2013-02-04 | 2013-02-04 | Functional inulin tablet and preparation method thereof |
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| CN104544057A (en) * | 2014-12-22 | 2015-04-29 | 佐源集团有限公司 | Inulin lozenge and preparation method thereof |
| CN104686891A (en) * | 2015-02-09 | 2015-06-10 | 新疆冠农果茸集团股份有限公司 | Synanthrin tablets and preparation method thereof |
| CN104814436A (en) * | 2015-05-18 | 2015-08-05 | 福建农林大学 | Ulvaceae functional oligosaccharide composite chewable tablet |
| CN108606328A (en) * | 2018-04-12 | 2018-10-02 | 内蒙古凯程农牧业科技有限公司 | A kind of inulin composite sheet, preparation method and rotary tablet machine |
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| CN108606328A (en) * | 2018-04-12 | 2018-10-02 | 内蒙古凯程农牧业科技有限公司 | A kind of inulin composite sheet, preparation method and rotary tablet machine |
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Application publication date: 20140806 |