CN103948929A - Anti-adhesion powder inhalation applied to orthopedic operation and preparation method of anti-adhesion powder inhalation - Google Patents
Anti-adhesion powder inhalation applied to orthopedic operation and preparation method of anti-adhesion powder inhalation Download PDFInfo
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- CN103948929A CN103948929A CN201410179309.1A CN201410179309A CN103948929A CN 103948929 A CN103948929 A CN 103948929A CN 201410179309 A CN201410179309 A CN 201410179309A CN 103948929 A CN103948929 A CN 103948929A
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- adhesion powder
- bone surgery
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Abstract
The invention belongs to the field of medicines, and particularly relates to anti-adhesion powder inhalation applied to an orthopedic operation and a preparation method of the anti-adhesion powder inhalation. The anti-adhesion powder inhalation consists of sodium hyaluronate, a chitin derivative and a large-molecular isolator, wherein the mass ratio of the sodium hyaluronate to the chitin derivative to the large-molecular isolator is 1: (0.3-1): (0.1-0.5). The preparation method comprises the following steps: weighing and mixing the sodium hyaluronate, the chitin derivative and the large-molecular isolator according to the formula, then grinding into fine powder, sieving the fine powder by use of a sieve of which the size is 200 meshes, packaging the sieved fine powder in aluminum foil bags, and sterilizing with ethylene oxide or microwave to obtain the anti-adhesion powder inhalation applied to the orthopedic operation. The anti-adhesion powder inhalation applied to the orthopedic operation has the advantages that all the components of the anti-adhesion powder inhalation cooperate with one another and are prepared into the powder inhalation for use, so the anti-adhesion powder inhalation has remarkable effects in prevention of post-operative joint tissue adhesion, wound repair and healing and pain relieving, also is stable in quality, low in cost and convenient to use, has good adhesion with tissues, and meets the clinical use requirements.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of bone surgery anti powder spray and preparation method thereof.
Background technology
Joint accretion refers to periarticular skin, muscle, tendon, and nervus vasculairs etc. change and the dyskinesia that causes.In the tissue of human body, have loose composition and fine and close composition, the former forms joint capsule, muscle conjunctive tissue layer, subcutaneous tissue etc., is all often movable part, and it is netted that the upper collagen fiber of histology and fine-structure mesh fiber do not have, and do not possess certain structure.In contrast, fine and close conjunctive tissue, as the fine and close network structure of formation of sarolemma, aponeurosis (aponeuroses) etc.The cicatrix forming after wound is exactly this tissue.In the therapeutic process of orthopaedics articular trauma, if keep the motion at this place, loose conjunctive tissue is kept existing, if limitation of movement in contrary therapeutic process, fine and close conjunctive tissue propagation, the mobility at impaired place is significantly limited, and this is the mechanism of wound posterior synechiae.In addition adhesion is that the splicing mechanism due to the inertia of modal joint is also identical therewith, and owing to lacking motion, the blood circulation open texture cripetura of slowing down, follows the string, slip and extensibility and the compact tissue that forms.Such process occurs in joint capsule, sarolemma, muscle conjunctive tissue, ligament etc., and causes joint motion limited.Even normal arthrodesis 4 weeks, the adhesion that also can produce certain degree.
In bone surgery, occur that joint accretion is common following three kinds of reasons: the adhesion of (1) wound posterior joint, as knee ligament, meniscus injury etc.; (2) after internal fixation, after Gypsum Fibrosum is fixing, after fixation with small splint.(3) the useless property used joint accretion, as joint of lumbar vertebra adhesion due to long-term bed, hip joint adhesion, Knee Adhesion.
Summary of the invention
According to above the deficiencies in the prior art, the invention provides a kind of bone surgery anti powder spray and preparation method thereof, be used for preventing around arthroscopy, nervous tissue, tissue adhesion after the bone surgery such as tendon repair, have the interior retention time of body long, preventing adhesiving effect acts on significantly.
A kind of bone surgery anti powder spray of the present invention, formed by hyaluronate sodium, chitin derivativ and macromole spacer, wherein, hyaluronate sodium, chitin derivativ and macromole spacer three's mass ratio is 1:0.3～1:0.1～0.5.
Wherein, described chitin derivativ is preferably the one in carboxymethyl chitin, Chitofilmer or succinyl chitin.
Macromole spacer is preferably the one in carboxymethyl cellulose, hydroxypropyl cellulose, dextran, chondroitin sulfate or sodium alginate.
The preparation method of anti powder spray for a kind of bone surgery, hyaluronate sodium, chitin derivativ and macromole spacer are taken to mixing by above-mentioned formula, then grind to form fine powder, fine powder is crossed to 200 mesh sieves, fine powder packaging of aluminium foil bag after sieving, after ethane via epoxyethane or microwave degerming, obtain bone surgery anti powder spray.
Hyaluronate sodium is a kind of linear polyanionic polysaccharide, and as the necessary material of Human Physiology, it is extensively present in the various tissues of animal, comprises connective tissue, skin, cartilage, vitreum and synovial fluid etc.Hyaluronate sodium molecular weight can reach 4,000,000 to five megadaltons, in aqueous solution, exists with random spiral form, has very large molecule volume, under low concentration, can be woven and penetrate mutually, makes it have specific rheological properties.Hyaluronate sodium prevents that the mechanism of postoperative joint tissue adhesion can be summarized as: (1) forms polymolecular network structure after dissolving, and injured tissue is separated with normal serous coat, plays space obstacle effect and lubrication, reduces friction; (2) suppress hemorrhage and ooze out, reducing the clot quantity that can form permanent adhesion skeleton, Profilin calmness; (3) suppress post-operation inflammatory cell migration and phagocytosis, suppress hematoblastic deposition, promote wound healing; (4) growth and the differentiation of stimulation serous coat cell, make wound serous coat reach physiological reparation.In addition, hyaluronate sodium powder spray is preventing being better than sodium hyaluronate solution and gel aspect tissue adhesion, sodium hyaluronate solution and gel are because concentration is low, molecular weight is little, be absorbed soon in vivo degraded, weaken its iris action at tissue surface, and hyaluronate sodium powder spray is sprayed on after tissue surface, there is a course of dissolution progressively, form high concentration gel in part simultaneously, local viscoelasticity is high and the interior retention time of body is long, forms effective barrier, so its preventing adhesiving effect is remarkable in the serous coat reparation phase.
Chitin derivativ is a kind of chitosan, and the present invention selects the one in carboxymethyl chitin, Chitofilmer or succinyl chitin.Chitin derivativ has good affinity to human body cell, antigenicity is low, safe, at human body injury energy activating cell, a large amount of collagen fiber that produce, collagen fiber can form rapidly careful skin, can scars, and special effect aspect treatment burn, scald, wound, accelerating wound healing, hemostasis, antiinflammatory.The powder spray that chitin derivativ is made has significant effect at prevention of postoperative tissue adhesion, wound healing and ease pain.
The present invention combines hyaluronate sodium with chitin derivativ, then is equipped with macromole spacer, and inventor, through lot of experiments, determines three's proportion relation, thereby reaches the maximization that prevents adhesion effect.
The invention has the advantages that: between each composition of medicine, cooperatively interact, and make powder spray use, adhesion between prevention of postoperative joint tissue, wound healing and ease pain have significant effect, and steady quality, cost is low, easy to use, good with the adhesiveness of tissue, meet clinical instructions for use.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.
Embodiment 1:
A kind of bone surgery anti powder spray, is made up of hyaluronate sodium, carboxymethyl chitin and carboxymethyl cellulose, and three's mass ratio is 1:1:0.5.
Embodiment 2:
A kind of bone surgery anti powder spray, is made up of hyaluronate sodium, Chitofilmer and dextran, and three's mass ratio is 1:0.5:0.3.
Embodiment 3:
A kind of bone surgery anti powder spray, is made up of hyaluronate sodium, succinyl chitin and sodium alginate, and three's mass ratio is 1:0.3:0.2.
Embodiment 1～3 is prepared according to following preparation method, hyaluronate sodium, chitin derivativ and macromole spacer are taken to mixing by above-mentioned formula, then grind to form fine powder, fine powder is crossed to 200 mesh sieves, fine powder packaging of aluminium foil bag after sieving, after ethane via epoxyethane or microwave degerming, obtain bone surgery anti powder spray.
Claims (4)
1. a bone surgery anti powder spray, it is characterized in that being formed by hyaluronate sodium, chitin derivativ and macromole spacer, wherein, hyaluronate sodium, chitin derivativ and macromole spacer three's mass ratio is 1:0.3～1:0.1～0.5.
2. bone surgery according to claim 1 anti powder spray, is characterized in that chitin derivativ is the one in carboxymethyl chitin, Chitofilmer or succinyl chitin.
3. bone surgery according to claim 1 anti powder spray, is characterized in that macromole spacer is the one in carboxymethyl cellulose, hydroxypropyl cellulose, dextran, chondroitin sulfate or sodium alginate.
4. the preparation method of a bone surgery use anti powder spray claimed in claim 1, it is characterized in that hyaluronate sodium, chitin derivativ and macromole spacer to take mixing by above-mentioned formula, then grind to form fine powder, fine powder is crossed to 200 mesh sieves, fine powder packaging of aluminium foil bag after sieving, after ethane via epoxyethane or microwave degerming, obtain bone surgery anti powder spray.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410179309.1A CN103948929A (en) | 2014-05-04 | 2014-05-04 | Anti-adhesion powder inhalation applied to orthopedic operation and preparation method of anti-adhesion powder inhalation |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410179309.1A CN103948929A (en) | 2014-05-04 | 2014-05-04 | Anti-adhesion powder inhalation applied to orthopedic operation and preparation method of anti-adhesion powder inhalation |
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Citations (4)
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| WO2001082863A2 (en) * | 2000-04-28 | 2001-11-08 | Fziomed, Inc. | Polyacid/polyalkylene oxide foams and gels and methods for their delivery |
| CN1899265A (en) * | 2006-07-08 | 2007-01-24 | 青岛博益特生物材料有限公司 | Medical dust cloud agent or granular agent and its use |
| CN101537205A (en) * | 2009-04-10 | 2009-09-23 | 暨南大学 | Degradable medical hemostatic non-viscous material and preparation method thereof |
| US20120064145A1 (en) * | 2010-09-09 | 2012-03-15 | China Medical University | Wound dressing |
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2014
- 2014-05-04 CN CN201410179309.1A patent/CN103948929A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001082863A2 (en) * | 2000-04-28 | 2001-11-08 | Fziomed, Inc. | Polyacid/polyalkylene oxide foams and gels and methods for their delivery |
| CN1899265A (en) * | 2006-07-08 | 2007-01-24 | 青岛博益特生物材料有限公司 | Medical dust cloud agent or granular agent and its use |
| CN101537205A (en) * | 2009-04-10 | 2009-09-23 | 暨南大学 | Degradable medical hemostatic non-viscous material and preparation method thereof |
| US20120064145A1 (en) * | 2010-09-09 | 2012-03-15 | China Medical University | Wound dressing |
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Application publication date: 20140730 |