CN103948623B - A kind of bone surgery anti powder spray and preparation method thereof - Google Patents
A kind of bone surgery anti powder spray and preparation method thereof Download PDFInfo
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- CN103948623B CN103948623B CN201410185092.5A CN201410185092A CN103948623B CN 103948623 B CN103948623 B CN 103948623B CN 201410185092 A CN201410185092 A CN 201410185092A CN 103948623 B CN103948623 B CN 103948623B
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- powder spray
- bone surgery
- hyaluronate sodium
- fine powder
- tissue
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Abstract
The invention belongs to field of medicaments, it is specifically related to a kind of bone surgery anti powder spray and preparation method thereof, it is made up of hyaluronate sodium, chitin derivativ and anti-inflammatory analgesic agent, wherein, the mass ratio of hyaluronate sodium, chitin derivativ and anti-inflammatory analgesic agent three is 1:0.3～1:0.01～0.1.During preparation, hyaluronate sodium, chitin derivativ and anti-inflammatory analgesic agent are weighed mixing by above-mentioned formula, is then ground to fine powder, fine powder is crossed 200 mesh sieves, after fine powder packaging of aluminium foil bag after sieving, ethane via epoxyethane or microwave are degerming, obtain bone surgery anti powder spray.It is an advantage of the current invention that: cooperate between each composition of medicine, and make powder spray use, in terms of adhesion between prevention of postoperative joint tissue, wound healing and easing pain and diminishing inflammation, there is obvious action, and steady quality, low cost, easy to use, good with the adhesiveness of tissue, meet Clinical practice requirement.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of bone surgery anti powder spray and preparation side thereof
Method.
Background technology
Joint accretion refers to periarticular skin, muscle, tendon, and nervus vasculairs etc. change and cause
The dyskinesia.Having loose composition and fine and close composition in the tissue of human body, the former constitutes joint capsule, muscle knot
Charge-coupled tissue layer, subcutaneous tissue etc., be all the most movable part, the upper collagen fiber of histology and fine-structure mesh fiber
Do not have netted, do not possess certain structure.In contrast, fine and close conjunctive tissue, as sarolemma, aponeurosis (aponeuroses) etc.
Composition densification network structure.The cicatrix formed after wound is exactly this tissue.The treatment of orthopaedics articular trauma
Cheng Zhong, if keeping the motion at this, then loose conjunctive tissue is maintained existing, if contrary therapeutic process
Middle limitation of movement, then fine and close conjunctive tissue propagation, the mobility at impaired place is significantly restricted, and this is viscous after wound
Mechanism even.In addition the splicing mechanism caused by the inertia of adhesion the most modal joint also with this
Identical, owing to lacking motion, blood circulation slows down open texture cripetura, follows the string, slides and extensibility
And form compact tissue.Such process occurs at joint capsule, sarolemma, muscle conjunctive tissue, ligament etc.,
And cause joint motion limited.Even normal arthrodesis is if 4 weeks, also can produce considerable degree of
Adhesion.
Bone surgery occurs joint accretion is common following three kinds of reasons: the posterior joint adhesion of (1) wound, as
Knee ligament, meniscus injury etc.；(2) Ineffective internal fixation, after plaster fixing, after fixation with small splint.
(3) the useless property used joint accretion, joint of lumbar vertebra adhesion as caused by long-term bed, hip joint adhesion, knee joint is glued
Even.
Summary of the invention
According to above the deficiencies in the prior art, the present invention provide a kind of bone surgery anti powder spray and
Preparation method, is used for preventing around arthroscopy, nervous tissue, after the bone surgery such as tendon repair
Tissue adhesion, has internal retention time long, preventing adhesiving effect obvious action.
A kind of bone surgery anti powder spray of the present invention, is derived by hyaluronate sodium, chitin
Thing and anti-inflammatory analgesic agent composition, wherein, hyaluronate sodium, chitin derivativ and anti-inflammatory analgesic agent three's
Mass ratio is 1:0.3～1:0.01～0.1.
Wherein, described chitin derivativ is preferably carboxymethyl chitin, Chitofilmer or succinyl
One in chitin.
Anti-inflammatory analgesic agent is preferably in diphenhydramine, amitriptyline, Ketanserine, ibuprofen or indomethacin
A kind of.
The preparation method of a kind of bone surgery anti powder spray, by hyaluronate sodium, chitin derivativ
Weigh mixing with anti-inflammatory analgesic agent by above-mentioned formula, be then ground to fine powder, fine powder is crossed 200 mesh sieves, mistake
After fine powder packaging of aluminium foil bag after sieve, ethane via epoxyethane or microwave are degerming, obtain bone surgery anti powder
Mist agent.
Hyaluronate sodium is a kind of linear polyanionic polysaccharide, and as material necessary to Human Physiology, it is wide
In the general various tissues being present in animal, including connective tissue, skin, cartilage, vitreum and synovial fluid etc..
Hyaluronate sodium molecular weight is up to 4 million to five megadaltons, in aqueous, with random spiral type
Formula exists, and has the biggest molecule volume, can be woven and penetrate mutually at low concentrations so that it is have
Specific rheological properties.Hyaluronate sodium prevents the mechanism of postoperative ankle tissue adhesion to be summarized as: (1)
Form polymolecular network structure after dissolving, injured tissue is separated with normal serous coat, play space obstacle and make
With and lubrication, reduce friction；(2) suppress hemorrhage and ooze out, reducing and can form permanent adhesion skeleton
Clot quantity, suppression albumen is calm；(3) suppression post-operation inflammatory cell migration and phagocytosis, suppression blood is little
The deposition of plate, promotes wound healing；(4) stimulate growth and the differentiation of serous coat cell, make wound serous coat reach
Physiological is repaired.Additionally, hyaluronate sodium powder spray to be better than hyaluronate sodium in terms of preventing tissue adhesion molten
Liquid and gel, sodium hyaluronate solution and gel are low due to concentration, and molecular weight is little, are inhaled the most soon
Incorporate solution, weaken its iris action at tissue surface, and hyaluronate sodium powder spray is sprayed on organization table
Behind face, having a progressively course of dissolution, be partially formed high concentration gel simultaneously, local visco-elasticity is high and internal
Retention time is long, forms effective barrier, so its preventing adhesiving effect is notable in the serous coat reparation phase.
Chitin derivativ is a kind of chitosan, the present invention select carboxymethyl chitin, Chitofilmer or
One in succinyl chitin.Chitin derivativ has good affinity, antigenicity to human body cell
Low, safety is high, at personal injury position energy activating cell, produces collagen fiber in a large number, and collagen fiber can
Quickly form careful skin, will not leave behind cicatrix, at treatment burn, scald, wound, acceleration wound more
Conjunction, hemostasis, antiinflammatory aspect special effect.The powder spray that chitin derivativ is made glues at prevention of postoperative tissue
Even, wound healing and ease pain have obvious action.
Hyaluronate sodium is combined by the present invention with chitin derivativ, then is equipped with anti-inflammatory analgesic agent, inventor
Through lot of experiments, determine three's proportion relation, thus reach to prevent the maximization of adhesion effect.
It is an advantage of the current invention that: cooperate between each composition of medicine, and make powder spray use,
Adhesion between prevention of postoperative joint tissue, wound healing and easing pain and diminishing inflammation aspect have obvious action, and
Steady quality, low cost, easy to use, good with the adhesiveness of tissue, meet Clinical practice requirement.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.
Embodiment 1:
A kind of bone surgery anti powder spray, by hyaluronate sodium, carboxymethyl chitin and diphenhydramine
Composition, the mass ratio of three is 1:1:0.1.
Embodiment 2:
A kind of bone surgery anti powder spray, by hyaluronate sodium, Chitofilmer and amitriptyline
Composition, the mass ratio of three is 1:0.5:0.05.
Embodiment 3:
A kind of bone surgery anti powder spray, by hyaluronate sodium, succinyl chitin and ibuprofen group
Becoming, the mass ratio of three is 1:0.3:0.02.
Embodiment 1～3 is prepared according to following preparation method, by hyaluronate sodium, chitin derivativ and antiinflammatory
Analgesic weighs mixing by above-mentioned formula, is then ground to fine powder, and fine powder is crossed 200 mesh sieves, thin after sieving
After powder packaging of aluminium foil bag, ethane via epoxyethane or microwave are degerming, obtain bone surgery anti powder spray.
Claims (1)
1. a bone surgery anti powder spray, it is characterised in that be made up of hyaluronate sodium, carboxymethyl chitin and diphenhydramine, wherein,
The mass ratio of hyaluronate sodium, carboxymethyl chitin and diphenhydramine composition is 1:1:0.1；
The preparation method of described bone surgery anti powder spray is: by hyaluronate sodium, carboxymethyl chitin and diphenhydramine by above-mentioned formula
Weigh mixing, be then ground to fine powder, fine powder is crossed 200 mesh sieves, fine powder packaging of aluminium foil bag after sieving, ethane via epoxyethane or microwave degerming after,
Obtain bone surgery anti powder spray.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410185092.5A CN103948623B (en) | 2014-05-04 | 2014-05-04 | A kind of bone surgery anti powder spray and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410185092.5A CN103948623B (en) | 2014-05-04 | 2014-05-04 | A kind of bone surgery anti powder spray and preparation method thereof |
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| Publication Number | Publication Date |
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| CN103948623A CN103948623A (en) | 2014-07-30 |
| CN103948623B true CN103948623B (en) | 2016-08-31 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1239657A (en) * | 1998-06-24 | 1999-12-29 | 凌沛学 | Antisticking particle and powder containing sodium hyaluronate and their preparation process |
| CN103285030A (en) * | 2012-02-28 | 2013-09-11 | 凌沛学 | Xanthan gum-containing anti-blocking preparation |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100386090C (en) * | 2006-07-08 | 2008-05-07 | 青岛博益特生物材料有限公司 | Medical dust cloud agent or granular agent and its use |
| KR101062068B1 (en) * | 2008-12-01 | 2011-09-02 | 포항공과대학교 산학협력단 | Anti-adhesion Composition |
-
2014
- 2014-05-04 CN CN201410185092.5A patent/CN103948623B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1239657A (en) * | 1998-06-24 | 1999-12-29 | 凌沛学 | Antisticking particle and powder containing sodium hyaluronate and their preparation process |
| CN103285030A (en) * | 2012-02-28 | 2013-09-11 | 凌沛学 | Xanthan gum-containing anti-blocking preparation |
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| CN103948623A (en) | 2014-07-30 |
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Granted publication date: 20160831 Termination date: 20170504 |