CN103926219B - A kind of device for artificial organs surface blood coagulation on-line checkingi and detection method - Google Patents
A kind of device for artificial organs surface blood coagulation on-line checkingi and detection method Download PDFInfo
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- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
The invention discloses a kind of device for artificial organs surface blood coagulation on-line checkingi, by arranging Fibre Optical Sensor on artificial organs, luminous source optical fiber emits beam and injects clear coat, and when not having blood, light occurs to be totally reflected in anticoagulant coatings inside and is received optical fiber and receives; When there being blood to flow through anticoagulant coatings surface, blood forms liquid film and covers anticoagulant coatings surface, and light can generating portion reflect, and the light that reception optical fiber receives can weaken, according to receiving the power of signal and whether stablizing and judge blood coagulation situation, judgement early and detect blood coagulation.By being fixed on below anticoagulant coatings by Fibre Optical Sensor, anticoagulant coatings can available protecting Fibre Optical Sensor, ensures high reliability and the serviceable life of Fibre Optical Sensor.Adopted by Fibre Optical Sensor the mode of array to be uniformly distributed in the surface of artificial organs, can judge the position of concrete blood coagulation more accurately, a situation arises better to judge blood coagulation, promptly and accurately to doctor's feedback information.
Description
Technical field
The invention belongs to medical checkout equipment technical field, be specifically related to a kind of device for artificial organs surface blood coagulation on-line checkingi and detection method.
Background technology
Artificial organs is temporary transient or permanently replaces the Prosthesis of some organ major function of health.Use and have more widely: 1. artificial lung (oxygenator) simulated lung carries out O
2with CO
2the device exchanged, makes body include the low venous oxygen of oxygen by oxygenator and is combined into containing the high arterial blood of oxygen.2. artificial heart (blood pump).Replace the device of cardiac ejection function, structure is similar to pump, and blood flow can be driven to overcome resistance along uniflux.Artificial heart and artificial lung are collectively referred to as heart-lung machine, in nineteen fifty-three first for human body, are mainly applicable to complicated openheart surgery.3. artificial kidney (haemodialyser).Man-made organ has a wide range of applications in medical science, and for suffering from various tissue, the treatment of the afunction of organ or the patient of dysfunction disease is significant.Widen the approach of disease treatment, added the chance that patient is rescued, and still continuing to make increasing patients benefit.
In artificial organs, for artificial heart, also there is biocompatibility issues with tissue, blood etc., wherein, all there is very large harm to artificial organs and human body in the surperficial blood coagulation problem caused with contacting blood of artificial organs.Blood clotting is the chemical chain reaction process of series of complex, has the mechanism maintaining blood proper flow in human body, neither hemorrhage, also can not cause thrombosis.But, when body whole body or local blood coagulation system strengthen or anticoagulation system weaken, fibrinolytic (thrombolysis) ability declines or anti-fibrinolytic enhancing, under the effect of some inducement (such as having the existence of artificial organs), the thrombus of thrombosis or formation just may be caused not cleared out external, blood is ubiquitous, and thrombus or embolism can occur in any position of health, the one group of disease causing vascular flow obviously to reduce to interrupt even completely.If thrombus occurs in artery, organ or tissue's severe ischemic or the blood flow ceases of blood supply can be caused, as cerebral blood supply insufficiency, unstable angina; Organ or tissue also can be caused downright bad because of ischemic, as acute myocardial infarction AMI, cerebral apoplexy.If thrombus occurs in vein, as Lower limb deep venous thrombosis can cause lower limb vascular backflow obstacle, cause oedema and venous insufficiency etc.
Embolism is the established thrombus of heart or Ink vessel transfusing, and after coming off, antegrade blood flow blocks the syndrome of other important organ blood vessels.As patients with atrial fibrillation often has thrombosis in atrium sinistrum.Thrombus once come off, then can get lodged in the cerebrovascular by antegrade blood flow, causes brain tissue necrosis (cerebral embolism); Lower-limb deep veins thrombus comes off, and can block pulmonary artery (pulmonary embolism), cause acute right ventricular failure, serious caused death.
If by some Disease epizootic caused by blood coagulation or thrombus in disease pathogenetic " upstream " stage, judgement early and detect blood coagulation, the meaning of so preventing for these major diseases is by self-evident.
Such as thrombus, inflammation, toxic reaction and many bad reactions such as carcinogenic is caused after material is as foreign matter implant into body.Wherein when implant and contacting blood, by protedogenous for product absorption with hematoblasticly to stick.It is generally acknowledged, after embedded material and contacting blood, its protein and lipid are adsorbed on material surface, because the conformation of these molecules changes, cause each composition in blood to interact, thus bring out the intrinsic coagulation reaction with clotting factor activation; Then there is the cell component such as blood platelet, red blood cell and be attached to protein surface, those are impelled the activation of blood coagulation system by discharging the III factor by the blood platelet generation sex change of sticking, produce Coagulation test, and then form thrombus, the formation of Intravascular Thrombus also can cause fatal consequence.Therefore, the bio-medical material of artificial blood vessel, artificial heart haematodocha, heart valve film, artificial lung etc. not only will have the elasticity similar to human vas and ductility and good fatigue durability etc., more to have good anticoagulant property antibacterium adhesion, namely thrombus is not produced at material surface, do not cause platelet, the infection centered by biomaterial does not occur.
Current artificial organs and blood contacting surface mainly adopt the material with anticoagulant property to carry out processing or applying on surface, not only increase manufacturing cost and the difficulty of organ, but also anticoagulant function can not be played completely, once generation blood coagulation, only have and just reflected by clinical manifestation to time more serious, often consequence painful and serious is greatly caused to patient.
Therefore, in view of above problem, be necessary to propose a kind of Hemostasis examination device, the position of concrete blood coagulation can be judged more accurately, a situation arises in better judgement blood coagulation, promptly and accurately give doctor's feedback information, the Disease epizootic that blood coagulation or thrombus can be caused is in disease pathogenetic " upstream " stage, judgement early and detection blood coagulation, ensure the health of patient.
Summary of the invention
In view of this, the invention provides a kind of device for artificial organs surface blood coagulation on-line checkingi and detection method, by arranging Fibre Optical Sensor, according to the power of light signal fed back and whether stablize and can better judge blood coagulation a situation arises, the position of the concrete blood coagulation of accurate judgement, promptly and accurately give doctor's feedback information, the Disease epizootic that blood coagulation or thrombus can be caused is in disease pathogenetic " upstream " stage, judgement early and detection blood coagulation, ensure the health of patient.
A kind of device for artificial organs surface blood coagulation on-line checkingi that object according to the present invention proposes, this device comprises Fibre Optical Sensor, described Fibre Optical Sensor is fixed on the surface of described artificial organs, the outer application of described Fibre Optical Sensor has one deck anticoagulant coatings, and described Fibre Optical Sensor is equally distributed multiple;
Described Fibre Optical Sensor comprises luminous source optical fiber and receives optical fiber, and described anticoagulant coatings is clear coat;
Luminous source optical fiber emits beam and injects anticoagulant coatings, and when not having blood, light occurs to be totally reflected in anticoagulant coatings inside and is received optical fiber and receives; When there being blood to flow through anticoagulant coatings surface, blood forms liquid film and covers anticoagulant coatings surface, and light can generating portion refraction, and receiving the light that receives of optical fiber can weaken, according to receiving the power of signal and whether stablizing and judge blood coagulation situation.
Preferably, described Fibre Optical Sensor is array format distribution.
Preferably, described anticoagulant coatings is diamond coatings.
Preferably, described artificial organs adopts the materials processing with anticoagulant property.
A kind of artificial organs surface blood coagulation online test method, the device for artificial organs surface blood coagulation on-line checkingi described in employing, concrete steps are as follows:
(1), machine-shaping artificial organs, and be fixedly installed Fibre Optical Sensor on the surface of artificial organs, and Fibre Optical Sensor is array distribution;
(2), at the outer application side anticoagulant coatings of Fibre Optical Sensor, cover Fibre Optical Sensor completely, and anticoagulant coatings is clear coat, forms sensing system between Fibre Optical Sensor and this clear coat;
(3), by artificial organs be applied in human body, luminous source optical fiber emits beam and injects clear coat, and when not having blood, light occurs to be totally reflected in clear coat inside and is received optical fiber and receives; When there being blood to flow through clear coat surface, blood forms liquid film and covers the surface of clear coat, and light can generating portion refraction, and receiving the light that optical fiber receives can weaken, but the signal received is a more stable value; When there being blood coagulation to occur, different clotting factor is different to the absorption of light, and can change the wavelength of incident light, obvious change can occur the light intensity received, thus judges the situation that blood coagulation occurs;
(4), by Received signal strength feedback export, be supplied to doctor and carry out judging and diagnosis and treatment early stage, Fibre Optical Sensor adopts the mode of array, accurately can judge the particular location of artificial organs blood coagulation.
Compared with prior art, disclosed by the inventionly for the device of artificial organs surface blood coagulation on-line checkingi and the advantage of detection method be:
1, by arranging Fibre Optical Sensor on artificial organs, luminous source optical fiber emits beam and injects clear coat, and when not having blood, light occurs to be totally reflected in anticoagulant coatings inside and is received optical fiber and receives; When there being blood to flow through anticoagulant coatings surface, blood forms liquid film and covers anticoagulant coatings surface, and light can generating portion reflect, and the light that reception optical fiber receives can weaken, according to receiving the power of signal and whether stablizing and judge blood coagulation situation, judgement early and detect blood coagulation.
2, by being fixed on below anticoagulant coatings by Fibre Optical Sensor, anticoagulant coatings can available protecting Fibre Optical Sensor, ensures high reliability and the serviceable life of Fibre Optical Sensor.
3, adopted by Fibre Optical Sensor the mode of array to be uniformly distributed in the surface of artificial organs, can judge the position of concrete blood coagulation more accurately, a situation arises better to judge blood coagulation, promptly and accurately to doctor's feedback information.
Accompanying drawing explanation
In order to be illustrated more clearly in the embodiment of the present invention or technical scheme of the prior art, be briefly described to the accompanying drawing used required in embodiment or description of the prior art below, apparently, accompanying drawing in the following describes is only some embodiments of the present invention, for those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawing can also be obtained according to these accompanying drawings.
Fig. 1 is the structural representation of a kind of device for artificial organs surface blood coagulation on-line checkingi disclosed by the invention.
A place light figure when Fig. 2 is not for having blood to flow through.
A place light figure when Fig. 3 is blood coagulation.
Fig. 4 is Fibre Optical Sensor partial enlargement distribution plan.
The title of the numeral in figure or the corresponding component representated by letter:
1, artificial organs 2, anticoagulant coatings 3, Fibre Optical Sensor 4, sludged blood
A, luminous source optical fiber B, reception optical fiber
Embodiment
Current artificial organs and blood contacting surface mainly adopt the material with anticoagulant property to carry out processing or applying on surface, not only increase manufacturing cost and the difficulty of organ, but also anticoagulant function can not be played completely, once generation blood coagulation, only have and just reflected by clinical manifestation to time more serious, often consequence painful and serious is greatly caused to patient.
The present invention is directed to deficiency of the prior art, provide a kind of device for artificial organs surface blood coagulation on-line checkingi and detection method, by arranging Fibre Optical Sensor, according to the power of light signal and whether stablize and can better judge blood coagulation a situation arises, the position of the concrete blood coagulation of accurate judgement, promptly and accurately give doctor's feedback information, the Disease epizootic that blood coagulation or thrombus can be caused is in disease pathogenetic " upstream " stage, judgement early and detection blood coagulation, ensure the health of patient.
To be clearly and completely described technical scheme of the present invention by embodiment below.Obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
As shown in Figure 1, for a device for artificial organs surface blood coagulation on-line checkingi, this device comprises Fibre Optical Sensor 3, and Fibre Optical Sensor 3 is fixed on the surface of artificial organs 1, the outer application of Fibre Optical Sensor 3 has one deck anticoagulant coatings 2, and Fibre Optical Sensor 3 is equally distributed multiple.
Fibre Optical Sensor 3 comprises luminous source optical fiber A and receives optical fiber B, and anticoagulant coatings is clear coat.Forming sensing system by adopting clear coat can coordinate with Fibre Optical Sensor, realizing by reflection ray the object detecting blood coagulation.Concrete principle is as follows:
As shown in Figure 2,3, luminous source optical fiber emits beam and injects clear coat, and when not having blood, light occurs to be totally reflected in clear coat inside and is received optical fiber and receives; When there being blood to flow through clear coat surface, blood forms liquid film and covers the surface of clear coat, and light can generating portion refraction, and receiving the light that optical fiber receives can weaken, but the signal received is a more stable value; When there being blood coagulation to occur, clotting factor is not different to the absorption of light, and can change the wavelength of incident light, obvious change can occur the light intensity received, thus judges the situation that blood coagulation occurs, and feeds back to doctor timely and carries out diagnosis in early stage.
Wherein, anticoagulant coatings can be diamond coatings, and diamond coatings is good anticoagulant material, realizes anti-coagulation properties, avoids blood to produce blood coagulation phenomenon on its surface, but anticoagulant coatings also other anticoagulant materials, specifically do not limit.
In addition, covering Fibre Optical Sensor completely by arranging anticoagulant coatings, avoiding Fibre Optical Sensor and contacting with the direct of blood, available protecting Fibre Optical Sensor, ensure the high reliability of Fibre Optical Sensor and long serviceable life.
As shown in Figure 4, Fibre Optical Sensor is array format distribution, can judge the position of concrete blood coagulation more accurately, and a situation arises better to judge blood coagulation, promptly and accurately to doctor's feedback information.
Artificial organs adopts the materials processing with anticoagulant property.
Artificial organs surface Hemostasis examination method, concrete steps are as follows:
(1), machine-shaping artificial organs, and be fixedly installed Fibre Optical Sensor on the surface of artificial organs, and Fibre Optical Sensor is array distribution;
(2), at the outer application side anticoagulant coatings of Fibre Optical Sensor, cover Fibre Optical Sensor completely, and anticoagulant coatings is clear coat, forms sensing system between Fibre Optical Sensor and this clear coat;
(3), by artificial organs be applied in human body, luminous source optical fiber emits beam and injects clear coat, and when not having blood, light occurs to be totally reflected in clear coat inside and is received optical fiber and receives; When there being blood to flow through clear coat surface, blood forms liquid film and covers the surface of clear coat, and light can generating portion refraction, and receiving the light that optical fiber receives can weaken, but the signal received is a more stable value; When there being blood coagulation to occur, different clotting factor is different to the absorption of light, and can change the wavelength of incident light, obvious change can occur the light intensity received, thus judges the situation that blood coagulation occurs;
(4), by Received signal strength feedback export, be supplied to doctor and carry out judging and diagnosis and treatment early stage, Fibre Optical Sensor adopts the mode of array, accurately can judge the particular location of artificial organs blood coagulation.
The invention discloses a kind of device for artificial organs surface blood coagulation on-line checkingi and detection method, by arranging Fibre Optical Sensor on artificial organs, luminous source optical fiber emits beam and injects clear coat, when not having blood, light occurs to be totally reflected in anticoagulant coatings inside and is received optical fiber and receives; When there being blood to flow through anticoagulant coatings surface, blood forms liquid film and covers anticoagulant coatings surface, and light can generating portion reflect, and the light that reception optical fiber receives can weaken, according to receiving the power of signal and whether stablizing and judge blood coagulation situation, judgement early and detect blood coagulation.
By being fixed on below anticoagulant coatings by Fibre Optical Sensor, anticoagulant coatings can available protecting Fibre Optical Sensor, ensures high reliability and the serviceable life of Fibre Optical Sensor.
Adopted by Fibre Optical Sensor the mode of array to be uniformly distributed in the surface of artificial organs, can judge the position of concrete blood coagulation more accurately, a situation arises better to judge blood coagulation, promptly and accurately to doctor's feedback information.
To the above-mentioned explanation of the disclosed embodiments, professional and technical personnel in the field are realized or uses the present invention.To be apparent for those skilled in the art to the multiple amendment of these embodiments, General Principle as defined herein can without departing from the spirit or scope of the present invention, realize in other embodiments.Therefore, the present invention can not be restricted to these embodiments shown in this article, but will meet the widest scope consistent with principle disclosed herein and features of novelty.
Claims (4)
1. the device for artificial organs surface blood coagulation on-line checkingi, it is characterized in that, this device comprises Fibre Optical Sensor, described Fibre Optical Sensor is fixed on the surface of described artificial organs, the outer application of described Fibre Optical Sensor has one deck anticoagulant coatings, and described Fibre Optical Sensor is equally distributed multiple;
Described Fibre Optical Sensor comprises luminous source optical fiber and receives optical fiber, and described anticoagulant coatings is clear coat;
Luminous source optical fiber emits beam and injects anticoagulant coatings, and when not having blood, light occurs to be totally reflected in anticoagulant coatings inside and is received optical fiber and receives; When there being blood to flow through anticoagulant coatings surface, blood forms liquid film and covers anticoagulant coatings surface, and light can generating portion refraction, and receiving the light that receives of optical fiber can weaken, according to receiving the power of signal and whether stablizing and judge blood coagulation situation.
2. as claimed in claim 1 for the device of artificial organs surface blood coagulation on-line checkingi, it is characterized in that, described Fibre Optical Sensor is array format distribution.
3., as claimed in claim 1 for the device of artificial organs surface blood coagulation on-line checkingi, it is characterized in that, described anticoagulant coatings is diamond coatings.
4., as claimed in claim 1 for the device of artificial organs surface blood coagulation on-line checkingi, it is characterized in that, described artificial organs adopts the materials processing with anticoagulant property.
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| CN106510628A (en) * | 2016-11-22 | 2017-03-22 | 李汶汶 | Blood exosmosis monitoring instrument |
| CN108114347A (en) * | 2016-11-28 | 2018-06-05 | 爱本斯南京医疗器械有限公司 | A kind of injection device and its method of work with monitoring blood function |
| WO2021016948A1 (en) * | 2019-07-31 | 2021-02-04 | 深圳迈瑞生物医疗电子股份有限公司 | Sample test module and sample analyzer |
| CN115813527B (en) * | 2023-01-17 | 2023-05-12 | 湖南轶疆医疗科技有限公司 | Surgical hemostatic device for artificial limb operation |
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| US20100312273A1 (en) * | 2009-06-03 | 2010-12-09 | Kim Robert E | Combined vascular and closure sheath |
| US20110082496A1 (en) * | 2009-10-02 | 2011-04-07 | Ashish Awasthi | Endovascular device and clotting system for the repair of vascular defects and malformations |
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| CN101024096A (en) * | 2007-02-12 | 2007-08-29 | 中山大学 | Surface modified artificial organ and its preparing method |
| CN102165304A (en) * | 2008-07-30 | 2011-08-24 | 皮尼奥洛股份公司 | Diode laser device for the non-invasive measurement of glycaemia |
| CN102368947A (en) * | 2009-01-08 | 2012-03-07 | 美国生物光学公司 | Probe apparatus for recognizing abnormal tissue |
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