CN103917222A - 用于对氧代谢进行分子成像的组合物和方法 - Google Patents

用于对氧代谢进行分子成像的组合物和方法 Download PDF

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Publication number
CN103917222A
CN103917222A CN201280055527.3A CN201280055527A CN103917222A CN 103917222 A CN103917222 A CN 103917222A CN 201280055527 A CN201280055527 A CN 201280055527A CN 103917222 A CN103917222 A CN 103917222A
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CN
China
Prior art keywords
oxygen
compositions
composition
tissue
approximately
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201280055527.3A
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English (en)
Chinese (zh)
Inventor
P·M·古普特
R·L·德拉帕兹
R·拉维尚德兰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rockland Technimed Ltd
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Rockland Technimed Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rockland Technimed Ltd filed Critical Rockland Technimed Ltd
Publication of CN103917222A publication Critical patent/CN103917222A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
CN201280055527.3A 2011-09-22 2012-09-22 用于对氧代谢进行分子成像的组合物和方法 Pending CN103917222A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161537823P 2011-09-22 2011-09-22
US61/537,823 2011-09-22
USPCT/US12/36604 2012-05-04
PCT/US2012/036604 WO2013043236A1 (en) 2011-09-22 2012-05-04 Compositions and methods useful for realtime in situ physiological molecular imaging of oxygen metabolism
PCT/US2012/056775 WO2013044186A1 (en) 2011-09-22 2012-09-22 Compositions and methods for molecular imaging of oxygen metabolism

Publications (1)

Publication Number Publication Date
CN103917222A true CN103917222A (zh) 2014-07-09

Family

ID=47914739

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280055527.3A Pending CN103917222A (zh) 2011-09-22 2012-09-22 用于对氧代谢进行分子成像的组合物和方法

Country Status (5)

Country Link
US (1) US20140234224A1 (https=)
EP (1) EP2758034A4 (https=)
CN (1) CN103917222A (https=)
IN (1) IN2014DN03197A (https=)
WO (2) WO2013043236A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3113766B1 (en) * 2014-03-05 2021-04-07 Evan C. Unger Fractionated radiotherapy and chemotherapy with an oxygen therapeutic
WO2015188040A2 (en) * 2014-06-05 2015-12-10 The Trustees Of Columbia University In The City Of New York Composition for use in imaging
JP6936226B2 (ja) * 2015-12-21 2021-09-15 ヌヴォックス ファーマ エル．エル．シー．Ｎｕｖｏｘ Ｐｈａｒｍａ Ｌ．Ｌ．Ｃ． フルオロカーボンナノエマルジョンの組成物
US20190365665A1 (en) * 2017-01-24 2019-12-05 Nuvox Pharma Llc Iso-osmotic and near iso-osmotic oxygen therapeutic formulations and methods thereof
US20180279878A1 (en) * 2017-04-04 2018-10-04 Canon Medical Systems Corporation Mri system, mri apparatus, and mri method
WO2019010445A1 (en) * 2017-07-07 2019-01-10 The Regents Of The University Of Colorado, A Body Corporate COMPOSITIONS AND METHOD FOR THE TREATMENT OF PULMONARY HYPERTENSION

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100267842A1 (en) * 2009-04-15 2010-10-21 Richard Kiral Emulsions of Perfluorocarbons

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US3993581A (en) * 1973-10-05 1976-11-23 The Green Cross Corporation Process for preparing stable oxygen transferable emulsion
US4252827A (en) * 1979-05-23 1981-02-24 The Green Cross Corporation Oxygen-transferable fluorocarbon emulsion
US5554125A (en) * 1987-07-08 1996-09-10 Reynolds; David L. Prefilled vial syringe
US4996041A (en) * 1988-08-19 1991-02-26 Toshiyuki Arai Method for introducing oxygen-17 into tissue for imaging in a magnetic resonance imaging system
DE4019062A1 (de) * 1989-08-30 1991-03-07 Kali Chemie Ag Stabilisierung von perfluorcarbonemulsionen und als emulsionsstabilisierende zusaetze verwendbare perfluorierte heterocyclische verbindungen
US20020150539A1 (en) * 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US5047627A (en) * 1990-05-18 1991-09-10 Abbott Laboratories Configuration fiber-optic blood gas sensor bundle and method of making
US7083572B2 (en) * 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
US6537246B1 (en) * 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6596235B2 (en) * 1999-09-30 2003-07-22 Therox, Inc. Method for blood oxygenation
US7179449B2 (en) * 2001-01-30 2007-02-20 Barnes-Jewish Hospital Enhanced ultrasound detection with temperature-dependent contrast agents
US7357937B2 (en) * 2002-09-24 2008-04-15 Therox, Inc. Perfluorocarbon emulsions with non-fluorinated surfactants
US8532730B2 (en) * 2006-10-04 2013-09-10 Dexcom, Inc. Analyte sensor
WO2006108047A2 (en) * 2005-04-05 2006-10-12 Biopure Corporation Oxygenated polymerized hemoglobin solutions and their uses for tissue visualization
US7410634B2 (en) * 2005-10-17 2008-08-12 Rockland Technimed Ltd. Tissue metabolic stress monitoring
EP2099408B1 (en) * 2006-11-28 2016-10-05 Wisconsin Alumni Research Foundation Fluoropolymer-based emulsions for the intravenous delivery of fluorinated volatile anesthetics
CN101199548B (zh) * 2007-12-11 2011-04-13 西安力邦医药科技有限责任公司 一种全氟化碳乳剂及其制备方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100267842A1 (en) * 2009-04-15 2010-10-21 Richard Kiral Emulsions of Perfluorocarbons

Also Published As

Publication number Publication date
IN2014DN03197A (https=) 2015-05-22
US20140234224A1 (en) 2014-08-21
EP2758034A4 (en) 2015-09-16
WO2013043236A1 (en) 2013-03-28
EP2758034A1 (en) 2014-07-30
WO2013044186A1 (en) 2013-03-28

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Application publication date: 20140709