CN103906515A - 治疗黏液表皮样癌的方法 - Google Patents

治疗黏液表皮样癌的方法 Download PDF

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Publication number
CN103906515A
CN103906515A CN201280047473.6A CN201280047473A CN103906515A CN 103906515 A CN103906515 A CN 103906515A CN 201280047473 A CN201280047473 A CN 201280047473A CN 103906515 A CN103906515 A CN 103906515A
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China
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replace
replaced
compound
methyl
alkyl group
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Pending
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CN201280047473.6A
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English (en)
Chinese (zh)
Inventor
J·D·格莱芬
吴丽姿
陈洁
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Dana Farber Cancer Institute Inc
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Dana Farber Cancer Institute Inc
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Publication of CN103906515A publication Critical patent/CN103906515A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201280047473.6A 2011-09-30 2012-09-27 治疗黏液表皮样癌的方法 Pending CN103906515A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161541758P 2011-09-30 2011-09-30
US61/541,758 2011-09-30
US201261660377P 2012-06-15 2012-06-15
US61/660,377 2012-06-15
PCT/US2012/057480 WO2013049300A1 (en) 2011-09-30 2012-09-27 Method of treating mucoepidermoid carcinoma

Publications (1)

Publication Number Publication Date
CN103906515A true CN103906515A (zh) 2014-07-02

Family

ID=47016842

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280047473.6A Pending CN103906515A (zh) 2011-09-30 2012-09-27 治疗黏液表皮样癌的方法

Country Status (12)

Country Link
US (1) US20140243396A1 (https=)
EP (1) EP2760445A1 (https=)
JP (1) JP2014532057A (https=)
KR (1) KR20140069038A (https=)
CN (1) CN103906515A (https=)
AU (1) AU2012316020A1 (https=)
BR (1) BR112014005730A2 (https=)
CA (1) CA2848065A1 (https=)
EA (1) EA201490725A1 (https=)
IN (1) IN2014CN02315A (https=)
MX (1) MX2014003873A (https=)
WO (1) WO2013049300A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1245095A1 (zh) 2015-05-20 2018-08-24 Novartis Ag 依维莫司(everolimus)与达托里昔布(dactolisib)的医药组合
CN110114070A (zh) 2016-11-23 2019-08-09 诺华公司 使用依维莫司(everolimus)、达托里昔布(dactolisib)或二者增强免疫反应的方法
US20200362303A1 (en) * 2017-11-30 2020-11-19 Kyoto University Maintenance-and-amplification method and differentiation induction method for primordial germ cells/primordial germ cell-like cells
US10596165B2 (en) 2018-02-12 2020-03-24 resTORbio, Inc. Combination therapies
CN108578016B (zh) 2018-04-26 2020-09-08 赛诺医疗科学技术股份有限公司 一种经心尖植入式二尖瓣瓣膜装置

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101541793A (zh) * 2006-11-20 2009-09-23 诺瓦提斯公司 2-甲基-2-[4-(3-甲基-2-氧代-8-喹啉-3-基-2,3-二氢-咪唑并[4,5-c]喹啉-1-基)-苯基]-丙腈的盐和晶型
WO2010051043A1 (en) * 2008-11-03 2010-05-06 Intellikine, Inc. Benzoxazole kinase inhibitors and methods of use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006110588A2 (en) 2005-04-11 2006-10-19 The Trustees Of Columbia University In The City Of New York Methods for treating mild cognitive impairment
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
WO2009052467A1 (en) * 2007-10-19 2009-04-23 Board Of Regents Of The University Of Texas System Methods of identifying pi-3-kinase inhibitor resistance
WO2009067397A2 (en) * 2007-11-19 2009-05-28 Ore Pharmaceuticals Inc. Treatment for solid tumors
WO2009155659A1 (en) * 2008-06-27 2009-12-30 The University Of Queensland Combination therapy
WO2011133668A2 (en) * 2010-04-20 2011-10-27 President And Fellows Of Harvard College Methods and compositions for the treatment of cancer
EP2640384A1 (en) * 2010-11-18 2013-09-25 Synta Pharmaceuticals Corp. Preselection of subjects for therapeutic treatment with oxygen sensitive agents based on hypoxic status

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101541793A (zh) * 2006-11-20 2009-09-23 诺瓦提斯公司 2-甲基-2-[4-(3-甲基-2-氧代-8-喹啉-3-基-2,3-二氢-咪唑并[4,5-c]喹啉-1-基)-苯基]-丙腈的盐和晶型
WO2010051043A1 (en) * 2008-11-03 2010-05-06 Intellikine, Inc. Benzoxazole kinase inhibitors and methods of use

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
PETER G. SMITH等: "The phosphodiesterase PDE4B limits cAMP-associated PI3K/AKT–dependent apoptosis in diffuse large B-cell lymphoma", 《BLOOD》 *
PETER G. SMITH等: "The phosphodiesterase PDE4B limits cAMP-associated PI3K/AKT–dependent apoptosis in diffuse large B-cell lymphoma", 《BLOOD》, vol. 15, no. 1, 26 August 2004 (2004-08-26) *
刘弈等: "p70 S6K信号通路在黏液表皮样癌发生中的作用", 《口腔医学》 *
刘弈等: "p70 S6K信号通路在黏液表皮样癌发生中的作用", 《口腔医学》, vol. 29, no. 1, 31 January 2009 (2009-01-31) *

Also Published As

Publication number Publication date
IN2014CN02315A (https=) 2015-06-19
WO2013049300A1 (en) 2013-04-04
EP2760445A1 (en) 2014-08-06
EA201490725A1 (ru) 2014-11-28
BR112014005730A2 (pt) 2017-03-28
AU2012316020A1 (en) 2013-05-09
JP2014532057A (ja) 2014-12-04
KR20140069038A (ko) 2014-06-09
US20140243396A1 (en) 2014-08-28
MX2014003873A (es) 2014-05-28
CA2848065A1 (en) 2013-04-04

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Application publication date: 20140702