CN103893699A - Traditional Chinese medicine watered pill preparation for treating advanced ovarian carcinoma - Google Patents

Abstract

The invention relates to a traditional Chinese medicine, and in particular to a traditional Chinese medicine watered pill preparation for treating advanced ovarian carcinoma. Ovarian cancer is a disease difficult to conquer, not easy to find in early, and basically advanced once found; the advanced patients are poor in prognosis and easy to reappear after an operation; the symptomatic treatment and modification according to symptoms, of the traditional Chinese medicine watered pill preparation for treating advanced ovarian carcinoma disclosed by the invention are freely applied and complementary with each other. The traditional Chinese medicine watered pill preparation for treating advanced ovarian carcinoma is composed of 22 traditional Chinese medicines of turtle shell, tortoise plastron, dandelion, patrinia, nightshade, oldenlandia diffusa, sculellaria barbata, areca-nut, myrrh, edible tulip, manis pentadactyla, dormant insect, fritillary, scutellaria baicalensis, pinellia ternata, arisaema cum bile, selfheal, pericarpium arecae, trigone, curcuma zedoary, cantharides and angelica sinensis; many medicines are combined and play the roles of promoting qi to activating blood, softening hard mass and eliminating diseases, removing dampness and eliminating phlegm, and detoxifying and removing stasis; the curative effect of the traditional Chinese medicine watered pill preparation for treating advanced ovarian carcinoma is superior to that of a Western medicine chemotherapy method, and capable of being applied by modification according to symptoms, alleviating the symptoms of patients, improving the survival quality of the patients, and prolonging the survival time of terminal cancer patients.

Description

A kind of ovarian cancer Chinese kmedicine bolus preparation in late period for the treatment of

Technical field: the present invention relates to traditional Chinese medical science patent medicine, especially a kind of ovarian cancer Chinese kmedicine bolus preparation in late period for the treatment of.

Background technology: ovarian cancer is gynecological's obstinate disease, is not easy early discovery is late period once finding substantially.And patients with terminal prognosis is poor, postoperative easy recurrence, still lacks effective Therapeutic Method at present.

Summary of the invention: ovarian cancer belongs to traditional Chinese medical science “ mass in the abdomen ", " gathering " category.When spiritlessness and weakness, lusterless complexion, emaciated physique, abdominal mass, thready and hesitant pulse, the dark violet card of tongue belong to stagnation of QI-blood; When abdominal distention gastric fullness, time have impractical swollen, the abdominal part of nauseating, face to have enclosed mass, subcutaneous nodule pressure symptom, rolling pulse tongue is dark, the white greasy disease of tongue belongs to phlegm-damp cohesion; When tired tired, the abdominal distention of heavy sensation of the body has that piece, xerostomia are not drunk, dry stool yellowish urine, the profound cunning of arteries and veins, disease that tongue is dark belong to damp and hot strongly fragrant poison; Sleepy when becoming thin, the grey god of face is light, the empty large unrooted of shortness of breath and palpitation, sweating while acting, deep-thready pulse, the disease of light red tongue belongs to deficiency of both QI and blood.

In " Elementary Medicine ", propose: " the pent-up impairment of the spleen, emaciation is thin, fights mutually and forms sarcoma with exopathogen." with gather with sick different name ， “ Disorder " with " amassing " is tangible levies, hardly do not move localized pain." abdominal mass " and " gathering ", Meeting and departing are irregular, what push away can move, migratory pain ， “ Disorder " genus mass formed by blood stasis, and " abdominal mass " belongs to disorder of QI, and the generation of primary disease is mainly zang-fu disharmony, disharmony between QI and blood, or because of new product, careless through row, hinder in air-cooled, or due to feelings will internal injury.

According to as above etiology and pathogenesis and all diseases of ovarian cancer, the present invention's " eliminate indigestion XIAOLIU WAN " symptomatic treatment and handle very skillfully and bring out the best in each other with disease plus-minus.Wherein have: Carapax Trionycis, Carapax et Plastrum Testudinis, Herba Taraxaci, Herba Patriniae, Herba Solani Nigri, Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Semen Arecae, Myrrha, Pseudobulbus Cremastrae Seu Pleiones, Squama Manis, Eupolyphaga Seu Steleophaga, Bulbus Fritillariae Uninbracteatae, Radix Scutellariae, the Rhizoma Pinelliae, Arisaema Cum Bile, Spica Prunellae, Pericarpium Arecae, Rhizoma Sparganii, Rhizoma Curcumae, Mylabris, Radix Angelicae Sinensis be totally 22 taste Chinese medicine compositions.Wherein Radix Angelicae Sinensis, Eupolyphaga Seu Steleophaga, Rhizoma Sparganii, Rhizoma Curcumae blood circulation promoting and blood stasis dispelling; Carapax Trionycis, Carapax et Plastrum Testudinis dispersing accumulated pathogens to resolve the mass, blood stasis dispelling intestinal stasis relieving; Squama Manis dredging collateral alter through; Semen Arecae circulation of qi promoting intestinal stasis relieving; Carapax Trionycis, Carapax et Plastrum Testudinis and Rhizoma Sparganii, Rhizoma Curcumae share the merit that can strengthen our blood circulation promoting and blood stasis dispelling, Xiao Disorder eliminating stagnation.Bulbus Fritillariae Uninbracteatae, the Rhizoma Pinelliae, Arisaema Cum Bile drying dampness to eliminate phlegm, circulation of qi promoting, spleen invigorating, warming middle-JIAO; Herba Hedyotidis Diffusae, Herba Taraxaci, Herba Patriniae, Radix Scutellariae, Herba Scutellariae Barbatae heat-clearing and toxic substances removing; Pericarpium Arecae, the removing toxic substances of Herba Solani Nigri clearing away heat-damp and promoting diuresis; The anticancer tumor of Mylabris, detoxification and removing stasis tissue regeneration promoting.All medicines share above, play altogether that promoting flow of QI and blood, Ruan Jian Xiao Disorder, dampness removing reduce phlegm, the merit of detoxicating and resolving stagnation of pathogens.

Detailed description of the invention: the present invention take Carapax Trionycis 10g, Carapax et Plastrum Testudinis 10g, Herba Taraxaci 20g, Herba Patriniae 20g, Herba Solani Nigri 20g, Pseudobulbus Cremastrae Seu Pleiones 10g, Squama Manis 10g, Herba Hedyotidis Diffusae 20g, Eupolyphaga Seu Steleophaga 15g, Herba Scutellariae Barbatae 15g, Semen Arecae 10g, Myrrha 8g, Bulbus Fritillariae Uninbracteatae 20g, Radix Scutellariae 25g, Rhizoma Pinelliae 8g, Arisaema Cum Bile 10g, Spica Prunellae 15g, Pericarpium Arecae 20g, Rhizoma Sparganii 10g, Rhizoma Curcumae 10g, Mylabris 1.5g, Radix Angelicae Sinensis 15g totally 22 taste Chinese medicines through selected drying and crushing cross 100 mesh sieves and water general for ball as Semen Firmianae size, for subsequent use after sterilizing.All ovarian cancer patients with terminal, postoperative recurrence patient all can take.Each 6g, day 2 times, one after each meal sooner or later, 20 days per courses for the treatment of.

Model case:

One, time so-and-so, female, 58 years old, first visit in June, 1994.Because ovarian cancer operation is also repeatedly found abdominal mass 15 days after chemotherapy, patient's requirement traditional Chinese medical herbal treatment.Patient's dim complexion is simple and unadorned, shortness of breath and fatigue, and anorexia, feelings will is gloomy, faint low voice, large loose stool is thin, pale tongue, there is indentation on limit, and tongue is white thin greasy, deep,thready and forceless pulse.Routine blood test: every liter of nine power of leukocyte 3*10, hematochrome 90g/L, every liter of nine power of platelet 8.0*10.

Chinese medical discrimination: deficiency of both QI and blood, deficiency of the liver and kindey.

Therapeutic scheme: benefiting QI and nourishing blood, reinforcing spleen and kidney, eliminate indigestion dispersing tumor.

1, throw " eliminate indigestion XIAOLIU WAN " two courses for the treatment of, day 2 times, each 6g, sub-service sooner or later.

2, take decoction: Radix Astragali 30g, Radix Codonopsis 15g, Radix Pseudostellariae 15g, Rhizoma Atractylodis Macrocephalae 20g, Rhizoma Dioscoreae 30g, Fructus Amomi 9g, Fructus Ligustri Lucidi 30g, Fructus Lycii 15g, Radix Angelicae Sinensis 20g, Colla Corii Asini 10g, parasitic 15g, Herba Leonuri 30g, Fructus Polygoni Orientalis 20g, Chu Shizi 30g, Radix Rubiae 15g, day potion, 250ml/ time, sub-service sooner or later.

Take medicine after ten days, this patient's hemocyte rises to every liter of nine power of 5*10, every liter of nine power of platelet 11*10, hematochrome 100g/L.Take medicine after four months, weight in patients increases, and diet improves, spiritual amelioration.Due to the medication of disease plus-minus, add Caulis Bambusae In Taenia, Haematitum as felt sick; Back pain adds Rhizoma Cibotii, Radix Dipsaci.Take u after Chinese medicine decoction a year and a half, patient has withdrawn decoction, following the service " eliminate indigestion XIAOLIU WAN " a year and a half with, repeatedly check and have no lump through Zhejiang Province's First Hospital, Zhejiang University Medical College The First Affiliated Hospital's B ultrasonic, patient can adhere to work closely over the past half year, and feels good.

Two, Luo, female, 55 years old, first visit in July, 1994, more than stomachache first quarter moon, upper left, lower abdominal lump are to be checked, in certain hospital's pyelography, left wall of urinary bladder pressurized.Being diagnosed as Ovarian Masses and upper left abdomen shifts.Hemogram and biochemical indicator are all in normal range, in carrying out laparotomy exploration in this institute by the end of July, the surgical findings upper left abdomen 18cm*10cm thing that swells, nodositas, matter is hard, left kidney pressurized, mesenteric adenophyma is large, and omentum majus is covered with the tuberosity that differs in size, the left ovary thing 8cm*6cm*6cm that swells, vascular surface anger is opened, and the swollen thing of row right ovary excision and upper left abdomen is got biopsy.Pathological diagnosis bilateral ovaries germinocarcinoma, in lymph node, oncocyte infiltrates.Postoperative western medical treatment is invalid, and patient and family members require traditional Chinese medical herbal treatment.

Tcm inspection: ordinary circumstance is poor, yellowish complexion is become thin, and can not walk, and skin sclera is without xanthochromia, and superficial lymph knot is little, pot belly, upper left abdomen is laid one's hand on and lump 12cm*12cm, left lower quadrant lump 4cm*4cm, obscure boundary, hard, fixing, Immobility voiced sound.Deep-thready pulse, white and thin fur.

Chinese medical discrimination: vital QI being weakened and pathogen being violent, deficiency of both QI and YIN, qi depression to blood stasis.

Therapeutic scheme:

1, throw " eliminate indigestion XIAOLIU WAN " two courses for the treatment of, each 6 grams, day twice, sub-service after meal sooner or later.

2, square medicine: Radix Codonopsis 20g, Radix Astragali 20g, Fructus Crataegi 20g, Herba Ecliptae 15g, Fructus Toosendan 10g, Radix Ophiopogonis 15g, Rhizoma Polygonati 15g, Rhizoma Dioscoreae 20g, Cortex Moutan 15g, Fructus Corni 20g, Radix Paeoniae Alba 20g, day potion, sub-service sooner or later, each 250ML.After serveing on three months, swollen thing is tactile unclear, and after 5 months, B ultrasonic is visited and the low echo agglomerate of 8cm*4cm.Within 9 months, postabdomen does not touch lump, until B ultrasonic scanning has no lump after 15 months, withdraws decoction, and following the service " eliminate indigestion XIAOLIU WAN " is checked B ultrasonic scanning and had no lump after 3 years.

Three, Wei so-and-so, female, 40 years old.In first visit in August, 1994.Starting self-induction lower abdomen from 93 year second half year has an enclosed mass, time have hypodynia, day by day increase 94 year first half of the year, pain exacerbates thereupon, then arrives county hospital inspection, is diagnosed as " hysteromyoma malignant change ".Advise higher level hospital to do further inspection.Zhejiang Province's First Hospital does pathological biopsy, is diagnosed as " mucous cystadenocarcinoma of ovary ", and conclusion is that " uterus adnexa cancer, shifts to pelvic cavity wall, cannot perform the operation." make the conditioning of going home, in here diagnosis and treatment by the end of August in the same year.First visit is shown in that patient becomes thin, bed groan, lower abdomen approximately has the large enclosed mass distending pain of two fists, that lays one's hand on is uneven, heating perspiration dysphoria with feverish sensation in the chest palms and soles, night dry mouth and throat, poor appetite, does not defecate for five days, red tongue, thin fur, thready and rapid pulse.

Chinese medical discrimination: qi depression to blood stasis, stasis of blood heat-transformation of a specified duration, pyretic toxicity knot is poly-.

Therapeutic Method: softening the hard mass relieving constipation, blood circulation promoting and blood stasis dispelling, eliminate indigestion dispersing tumor.

Side's medicine: 1, Radix Et Rhizoma Rhei end 2g, Natrii Sulfas 1.5g, takes after mixing it with water, twice of day.Take this side stool logical, after leading to, need not take more.

2, two courses for the treatment of of eliminate indigestion XIAOLIU WAN, days three times, 5 grams each, morning, noon and afternoon sub-service.

More than the bimester for the treatment of, lower abdomen enclosed mass dwindles gradually, and diet is as usual, haves a medical check-up after three months in treatment, and lower abdomen enclosed mass is remaining as large in egg, but without any discomfort.Take medicine because patient detests, do not listen dissuasion, drug withdrawal voluntarily, but followed up a case by regular visits to after 1 year half, in abdomen, enclosed mass is not controlled from disappearing, and is miracle in fact.

Four, Zhao so-and-so, female, 50 years old, first visit in March nineteen ninety-five.Because of ascites, oliguria after ovarian cancer operation, come here medical.Be diagnosed as ovarian cancer through certain large hospital, and ovary and total hysterectomy inside fascia, and postoperative chemotherapy.Through Zhejiang University Medical College The First Affiliated Hospital check, find that stomach wall extensively shifts, in January, 95 row perform the operation for the second time, in art, see stomach wall, bladder left and right and top cancerometastasis, only make Partial Resection.The permanent disunion of postoperative wound, pathologic finding is " mucus shape mamillary Ovarian Cystadenocarcinoma ".Sb.'s illness took a turn for the worse occurs expanding, ascites, and urine amount is few, defecates and does not understand for many days, poor appetite, unable, moving difficulty.Two arteries and veins are profound carefully unable, and thin fur white edge has indentation.

Chinese medical discrimination: the stagnant poison knot of the stasis of blood, cold and heat are staggered.

Therapeutic Method: warming YANG YIN nourishing, removing blood stasis with potent drugs heals, and captures.

Side's medicine: 1, two courses for the treatment of of eliminate indigestion XIAOLIU WAN, days three times, 5 grams each.

2, decoction: Pericarpium Citri Reticulatae 15g, Rhizoma Alpiniae Officinarum 10g, Rhizoma Zingiberis 10g, Ramulus Cinnamomi 25g, Radix Scrophulariae 30g, Talcum 20g, Rhizoma Cyperi 20g, Fructus Aurantii Immaturus 10g, Radix Rehmanniae 10g, Radix Rehmanniae Preparata 10g, Rhizoma Polygonati Odorati 10g, Radix Astragali 30g, Rhizoma Dioscoreae 20g, Fructus Lycii 15g, Semen Pharbitidis 30g, Radix Et Rhizoma Rhei 20g (under rear), Matrii Sulfas Exsiccatus 15g (taking after mixing it with water).

Defecation tonneau after taking medicine ten, ascites disappears.After 15 days, withdraw decoction, after three months, without all discomforts, after 1 year, follow up a case by regular visits to and have no recurrence.

The present invention's " eliminate indigestion XIAOLIU WAN " takes clinical observation by 39 routine Patients with Advanced Ovarian Carcinomas, wherein postoperative recurrence person 9 examples, second operation person 3 examples, without operator 12 examples, there are not person's 6 examples in hydrothorax ascites simultaneously, simple ascites person's 9 examples. above all taking " eliminate indigestion XIAOLIU WAN " as main, and with disease plus-minus conversion application.Its motility and mobility are that other treatment method is incomparable.Above patient does not all adhere to taking medicine half a year to three year not etc., adds and subtracts with disease according to determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs principle, and curative effect is summed up: responder's 36 examples, total effective rate 93%.The routine survival of patients of Long-term 39 accounts for 14 examples of 23%, 1 to 3 year with 9 interior examples in 1 year, accounts for 11 examples of 36%, 3 to 5 year, accounts for 26%, 5 year 5 above example, accounts for 15%.

According to efficacy analysis, the present invention's " eliminate indigestion XIAOLIU WAN " uses with disease plus-minus, and its curative effect is better than doctor trained in Western medicine embolic chemotherapy, can add and subtract to the ill application, alleviates patient's symptom, improves life in patients, extends the survival period of patient with advanced cancer.

Claims (1)

1. treat the ovarian cancer Chinese kmedicine bolus preparation in late period, it is characterized in that prescription compatibility and each Chinese medicine weight: Carapax Trionycis 10g, Carapax et Plastrum Testudinis 10g, Herba Taraxaci 20g, Herba Patriniae 20g, Herba Solani Nigri 20g, Pseudobulbus Cremastrae Seu Pleiones 10g, Squama Manis 10g, Herba Hedyotidis Diffusae 20g, Eupolyphaga Seu Steleophaga 15g, Herba Scutellariae Barbatae 15g, Semen Arecae 10g, Myrrha 8g, Bulbus Fritillariae Uninbracteatae 20g, Radix Scutellariae 25g, Rhizoma Pinelliae 8g, Arisaema Cum Bile 10g, Spica Prunellae 15g, Pericarpium Arecae 20g, Rhizoma Sparganii 10g, Rhizoma Curcumae 10g, Mylabris 1.5g, Radix Angelicae Sinensis 15g.