CN103893313A - Compound traditional Chinese medicine oral liquid for treating female postpartum syndrome and production method thereof - Google Patents
Compound traditional Chinese medicine oral liquid for treating female postpartum syndrome and production method thereof Download PDFInfo
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- CN103893313A CN103893313A CN201410079244.3A CN201410079244A CN103893313A CN 103893313 A CN103893313 A CN 103893313A CN 201410079244 A CN201410079244 A CN 201410079244A CN 103893313 A CN103893313 A CN 103893313A
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Abstract
The invention discloses compound traditional Chinese medicine oral liquid for treating female postpartum syndrome and a production method thereof. The compound traditional Chinese medicine oral liquid is characterized by being prepared from the following crude drugs in parts by weight: 150-250 parts of motherwort, 100-150 parts of flowers carthami, 100-150 parts of root of common peony, 5-100 parts of peach kernel, 50-100 parts of liquorice, 100-200 parts of angelica sinensis, 50-100 parts of radix achyranthis bidentatae, 80-10 parts of Tween, 5 parts of sodium benzoate and water. The recovery rate is 93.4%, the recurrence rate is 4.1%, the recovery rate on cow postpartum diseases is 90.2%, and the recurrence rate is 2-7% after the product disclosed by the invention is applied to treatment of sow postpartum diseases.
Description
Technical field
The present invention relates to a kind of medicine for animals, especially a kind of herbal mixture oral liquid and production method thereof for the treatment of female animal postpartum syndrome.
Background technology
" in healthy energy deposits, heresy can not be done; The institute of heresy plays, and its gas must be empty.", female animal puerperal, gas, blood, the serious virtual loss of body fluid, due to positive weakness of QI void, the pathogen morbidity of taking advantage of a weak point.Female animal puerperal disease is normally not good at due to pregnancy period feeding and management, and nutrition, trace element etc. supplement not in place, and conceived process consumes excessive, and forced labour is excessive; When childbirth, infect, puerperal the stagnation of QI, blood deficiency bacterial infection, cause the generation of obstetrics' disease, after female animal puerperal infection disease, not only can cause self-disease to occur, produce the phenomenons such as metritis, endometritis, placenta retention, prolonged lochiorrhea, also can be by breast-feeding, the mode cross infection piglet such as contact, the intestinal tract diseases such as the common Huang of piglet, Hakuri, and mortality rate is high, the female animal that suffers from puerperal disease also can affect ensuing breeding, there is non-estrus, return feelings, the phenomenon such as join unsuccessfully repeatly, bring very large economic loss to breeding production.The current treatment for female animal puerperal disease, many Bian antibiotic therapies, but antibiotics on the one hand life-time service can make pathogen develop immunity to drugs, can bring larger toxic and side effects to carcass internal organs (liver,kidney,spleen etc.) again on the other hand, Chinese medicine in the history of state-owned several thousand, inside information is abundant, is the rarity of the Chinese nation.Along with chemicals drug resistance strengthens gradually, food-safety problem comes into one's own gradually, and the Chinese medicine preparation that has no drug resistance, has no side effect more and more comes into one's own.If any people with returning the loose treatment of stilbene female animal postpartum syndrome to receive certain effect, returning stilbene, loose to mainly contain following component raw material medicine formulated: each 30 grams of Radix Codonopsis, the Radix Astragali, Radix Angelicae Sinensis, each 25 grams of Pollen Tyjphae (parched), Herba Schizonepetae (parched), Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Pericarpium Citri Reticulatae, 15 grams of Rhizoma Alismatis, 10 grams, Radix Glycyrrhizae, 120 grams, brown sugar.And for example Chinese patent 201310021473.5 discloses a kind of Chinese medicine composition of preventing and treating female animal postpartum syndrome and preparation method thereof, it is made up of following component: Herba Leonuri 45-65 gram, Radix Codonopsis 5-12 gram, Radix Astragali 12-20 gram, Radix Angelicae Sinensis 2-6 gram, Semen Persicae 2-8 gram, river key 2-8 gram, Radix Glycyrrhizae 1-5 gram.Treatment female animal postpartum syndrome is also received to better effects, but use in general treatment by Chinese herbs female animal postpartum syndrome kind less, effect has much room for improvement.Also have the mode of at present clinical conventional vagina perfusion to carry out the clearing heat in the pericardium, sterilization treatment, not only troublesome poeration of this mode, and usually can cause serious stimulation damage to female animal uterus, vagina.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, provide a kind of safe, effective, non-stimulated, have no side effect, herbal mixture oral liquid and the production method thereof of easy to use, eutherapeutic treatment female animal postpartum syndrome.Object of the present invention realizes by following technical proposals, and a kind of herbal mixture oral liquid for the treatment of female animal postpartum syndrome is formulated by following bulk drugs component and weight ratio:
Herba Leonuri 150-250 part, Flos Carthami 100-150 part, Radix Paeoniae Rubra 100-150 part, Semen Persicae 50-100 part, Radix Glycyrrhizae 50-100 part, Radix Angelicae Sinensis 100-200 part, Radix Achyranthis Bidentatae 50-100 part, Tween 80-10 part, 5 parts of sodium benzoate and suitable quantity of water.
The production method of product of the present invention follows these steps to carry out:
1, decoct and extract: get Herba Leonuri, Flos Carthami, Radix Paeoniae Rubra, Semen Persicae, Radix Glycyrrhizae, Radix Angelicae Sinensis, Radix Achyranthis Bidentatae and be placed in multi-function extractor, decoct 3 times, add respectively 8-12 doubly to measure water for injection at every turn and decoct extraction;
2, filtering and concentrating: after having decocted, filter, remove filtering residue, collect filtrate, merge three times filtrate, be evaporated to clear paste;
3, ethanol extraction: to the ethanol that adds 95% in the clear paste after concentrated, make solution contain alcohol amount and reach 85%, hold over night, is filtered to clear and brightly, then reclaims ethanol to without alcohol taste;
4, mixing, subpackage: the medicinal liquid reclaiming after ethanol adds suitable quantity of water, stirs, add tween 80 to stir molten most, add sodium benzoate to stir molten most, then add water for injection to nearly aequum, adjust pH value 5.0 ~ 7.0, supplementing water is to aequum, and the fill of oral administration solution bottle, seals and get final product.
Main effect of Chinese medicine in the present invention:
Herba Leonuri: effective ingredient is Herba Leonuri element (Leonurin), for oral administration can distending the blood vessels and make blood pressure drops, and there is an adrenergic effect of antagonism, can control arteriosclerotic and neuropathic hypertension, can increase again the frequency of uterus movement, for promoting uterotonic puerperal, and long-term metrorrhagia is caused languisher effectively, therefore be widely used in manage property after complete, the frequent fetal movement of Massive Bleeding, lochiorrhea, puerperal uterine contraction, uterine prolapse and the inferior disease of red and white leukorrhea.
Flos Carthami: there is blood circulation promoting and blood stasis dispelling effect, be usually used in dysmenorrhea, amenorrhea, menoxenia due to blood stasis, post partum longtime lochia, waist abdomen pain, enclosed mass pain in abdomen, injury from falling down swells and ache, can single decoction, also can be with other blood circulation promoting medicine adapteds to strengthen the efficacy of a drug.
Radix Paeoniae Rubra: clots absorbing, pain relieving, removing heat from blood, detumescence.Cure mainly: control that the stagnant amenorrhea of the stasis of blood, hernia abdominal mass gather, stomachache, hypochondriac pain, epistaxis, dysentery, discharging fresh blood stool, conjunctival congestion, carbuncle, injury from falling down.
Semen Persicae: blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, Yong Yu WEIJIA mass in the abdomen, injury from falling down, dryness of the intestine constipation.
Radix Glycyrrhizae: for insufficiency of heart-QI, severe palpitation, irregularly intermittent and regularly intermittent pulse, and deficiency of spleen-QI and stomach-QI, fatigue and weakness; Ulcer sores, laryngopharynx swelling and pain, asthma and cough etc.
Radix Angelicae Sinensis: enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation, cure mainly all cards of blood deficiency; Lump in the abdomen knot is poly-; Metrorrhagia; Asthenia cold abdominalgia; Flaccidity syndrome and arthralgia syndrome; Numbness of the skin; Dryness of the intestine dyschezia; Heavy after bloody dysentery; Ulcer sores; Injury from falling down.
Radix Achyranthis Bidentatae: cure mainly soreness of waist and knee joint; Flaccidity and weakness of the lower limbs; Amenorrhea due to stagnation of blood; Puerperal abdominal pain due to blood stasis; Lump in the abdomen; Retention of placenta; Pyretic stranguria; Stranguria with blood; Traumatic injury; Carbuncle malignant boil; Laryngopharynx swelling and pain.
The present invention utilizes the Chinese medicine of multiple blood circulation promoting and blood stasis dispelling, by nature and flavor and the function science compatibility of each component, utilizes the synergism producing between each medicine, obtained better treatment female animal postpartum syndrome effect.Through zoopery, cure rate reach more than 90% and relapse rate.
Animal experiment:
In year October in February, 2012 to 2013, adopt this reagent to treat altogether 147 ill female animals, wherein 41 of cattle, 106 of pigs, main clinic symptoms for stomachache, the back of a bow, appetite are low, prolonged lochiorrhea, placenta retention, piglet diarrhea, milk be thin etc.Adopt reagent to gavage treatment, each porcine 50-100ml, cattle 200-300ml, 1 time on the one, is used in conjunction 3 times.
Result of the test: the cure rate of application reagent treatment sow puerperal disease is 93.4%, and relapse rate is 4.1%, and the cure rate of cow puerperal disease is 90.2%, and relapse rate is 2.7%.
Using method: gavage treatment, each porcine, sheep 50-100ml, cattle, horse 200-300ml, 1 time on the one, be used in conjunction 3 times.
Detailed description of the invention
Embodiment 1, a kind of herbal mixture oral liquid and production method thereof for the treatment of female animal postpartum syndrome, follows these steps to carry out:
1, decoct and extract: get Herba Leonuri 10kg, Flos Carthami 7.5kg, Radix Paeoniae Rubra 7.5kg, Semen Persicae 5.0kg, Radix Glycyrrhizae 5.0kg, Radix Angelicae Sinensis 10kg, Radix Achyranthis Bidentatae 5.0kg (Yongtai Pharmaceutical Chemical Industry Machinery Factory, Chengdu in multi-function extractor, TNG-500), decoct 3 times, add respectively 12 times, 10 times amounts, 8 times of water gagings to decoct extraction:
2, filtering and concentrating: after having decocted, filter, remove filtering residue, collect filtrate, merge three times filtrate, be evaporated to clear paste;
3, ethanol extraction: to the ethanol that adds 95% in the clear paste after concentrated, make solution contain alcohol amount and reach 85%, hold over night, is filtered to clear and brightly, then reclaims ethanol to without alcohol taste;
4, mixing, subpackage: the medicinal liquid reclaiming after ethanol adds suitable quantity of water, stir, add tween 80 0.5kg to stir molten most, add sodium benzoate 0.25kg to stir molten most, then add water for injection to nearly 50kg, adjust pH value 5.0 ~ 7.0, supplementing water is to 50kg, the fill of oral administration solution bottle, seals and get final product.
Embodiment 2
Treat herbal mixture oral liquid and the production method thereof of female animal postpartum syndrome, follow these steps to carry out:
1, decoct and extract: get Herba Leonuri 12.5kg, Flos Carthami 10.0kg, Radix Paeoniae Rubra 7.5kg, Semen Persicae 5.0kg, Radix Glycyrrhizae 2.5kg, Radix Angelicae Sinensis 5.0kg, Radix Achyranthis Bidentatae 7.5kg in multi-function extractor, decoct 3 times, add respectively 12 times, 10 times amounts, 8 times of water gagings to decoct extraction:
2, filtering and concentrating: after having decocted, filter, remove filtering residue, collect filtrate, merge three times filtrate, be evaporated to clear paste;
3, ethanol extraction: to the ethanol that adds 95% in the clear paste after concentrated, make solution contain alcohol amount and reach 85%, hold over night, is filtered to clear and brightly, then reclaims ethanol to without alcohol taste;
4, mixing, subpackage: the medicinal liquid reclaiming after ethanol adds suitable quantity of water, stir, add tween 80 0.5kg to stir molten most, add sodium benzoate 0.25kg to stir molten most, then add water for injection to nearly 50kg, adjust pH value 5.0 ~ 7.0, supplementing water is to 50kg, the fill of oral administration solution bottle, seals and get final product.
Embodiment 3
Treat herbal mixture oral liquid and the production method thereof of female animal postpartum syndrome, follow these steps to carry out:
1, decoct and extract: get Herba Leonuri 11kg, Flos Carthami 9kg, Radix Paeoniae Rubra 8kg, Semen Persicae 5kg, Radix Glycyrrhizae 4kg, Radix Angelicae Sinensis 8kg, Radix Achyranthis Bidentatae 5kg in multi-function extractor, decoct 3 times, add respectively 12 times, 10 times amounts, 8 times of amount waters for injection to decoct and carry:
2, filtering and concentrating: after having decocted, filter, remove filtering residue, collect filtrate, merge three times filtrate, be evaporated to clear paste;
3, ethanol extraction: to the ethanol that adds 95% in the clear paste after concentrated, make solution contain alcohol amount and reach 85%, hold over night, is filtered to clear and brightly, then reclaims ethanol to without alcohol taste;
4, mixing, subpackage: the medicinal liquid reclaiming after ethanol adds suitable quantity of water, stir, add tween 80 0.5kg to stir molten most, add sodium benzoate 0.25kg to stir molten most, then add water for injection to nearly 50kg, adjust pH value 5.0 ~ 7.0, supplementing water is to 50kg, the fill of oral administration solution bottle, seals and get final product.
Claims (2)
1. a herbal mixture oral liquid for the treatment of female animal postpartum syndrome, is characterized in that, formulated by following bulk drugs component and weight ratio:
Herba Leonuri 150-250 part, Flos Carthami 100-150 part, Radix Paeoniae Rubra 100-150 part, Semen Persicae 50-100 part, Radix Glycyrrhizae 50-100 part, Radix Angelicae Sinensis 100-200 part, Radix Achyranthis Bidentatae 50-100 part, Tween 80-10 part, 5 parts of sodium benzoate and water.
2. a production method for a kind of herbal mixture oral liquid for the treatment of female animal postpartum syndrome claimed in claim 1, is characterized in that, follows these steps to carry out:
(1) decoct and extract: get Herba Leonuri, Flos Carthami, Radix Paeoniae Rubra, Semen Persicae, Radix Glycyrrhizae, Radix Angelicae Sinensis, Radix Achyranthis Bidentatae and be placed in multi-function extractor, decoct 3 times, add respectively 8-12 doubly to measure water for injection at every turn and decoct extraction;
(2) filtering and concentrating: after having decocted, filter, remove filtering residue, collect filtrate, merge three times filtrate, be evaporated to clear paste;
(3) ethanol extraction: to the ethanol that adds 95% in the clear paste after concentrated, make solution contain alcohol amount and reach 85%, hold over night, is filtered to clear and brightly, then reclaims ethanol to without alcohol taste;
(4) mixing, subpackage: the medicinal liquid reclaiming after ethanol adds suitable quantity of water, stirs, adds tween 80 to stir molten most, add sodium benzoate to stir molten most, then add water for injection to nearly aequum, adjust pH value 5.0 ~ 7.0, supplementing water is to aequum, and the fill of oral administration solution bottle, seals and get final product.
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| CN201410079244.3A CN103893313B (en) | 2014-03-06 | 2014-03-06 | A kind of herbal mixture oral liquid and production method thereof for the treatment of dam postpartum syndrome |
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| CN201410079244.3A CN103893313B (en) | 2014-03-06 | 2014-03-06 | A kind of herbal mixture oral liquid and production method thereof for the treatment of dam postpartum syndrome |
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| CN103893313A true CN103893313A (en) | 2014-07-02 |
| CN103893313B CN103893313B (en) | 2016-04-20 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108077578A (en) * | 2017-12-29 | 2018-05-29 | 常德惠生九鼎食品有限公司 | It is a kind of for the Chinese medicine composition of postpartum sow and feed and preparation method thereof |
| CN108785506A (en) * | 2018-09-26 | 2018-11-13 | 四川兴华药业有限责任公司 | It is a kind of to treat snorting compound rhizoma anemarrhenae oral liquid of livestock and poultry cough and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103070944A (en) * | 2013-01-22 | 2013-05-01 | 无锡正大畜禽有限公司 | Chinese medicinal composition for preventing and treating dam postpartum syndrome and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103070944A (en) * | 2013-01-22 | 2013-05-01 | 无锡正大畜禽有限公司 | Chinese medicinal composition for preventing and treating dam postpartum syndrome and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 卢永华、雷明亮: "中西结合防治猪产后综合症", 《中兽医学杂志》 * |
| 杨国亮、吴国华: "母猪产后综合症诊断与防治", 《中兽医医药杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108077578A (en) * | 2017-12-29 | 2018-05-29 | 常德惠生九鼎食品有限公司 | It is a kind of for the Chinese medicine composition of postpartum sow and feed and preparation method thereof |
| CN108785506A (en) * | 2018-09-26 | 2018-11-13 | 四川兴华药业有限责任公司 | It is a kind of to treat snorting compound rhizoma anemarrhenae oral liquid of livestock and poultry cough and preparation method thereof |
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| CN103893313B (en) | 2016-04-20 |
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