CN103892956A - Condom with antiviral effect - Google Patents
Condom with antiviral effect Download PDFInfo
- Publication number
- CN103892956A CN103892956A CN201210578469.4A CN201210578469A CN103892956A CN 103892956 A CN103892956 A CN 103892956A CN 201210578469 A CN201210578469 A CN 201210578469A CN 103892956 A CN103892956 A CN 103892956A
- Authority
- CN
- China
- Prior art keywords
- condom
- rhizoma bistortae
- extract
- lubricant
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
The invention discloses a condom with an antiviral effect. Dragonwort extractives are included in the lubricant of the condom. According to the condom with the antiviral effect, condyloma acuminata and other venereal diseases caused by the HPV can be prevented from spreading from the source, and the wide application prospects are achieved.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of condom with antivirus action.
Background technology
Condom is to stop and become pregnant with the form of non-medicine, and latex prophylactic is to use in the world the most general contraceptive device, and the annual consumption of China reaches 2,000,000,000.Along with the rapid spread of the sexually transmitted disease (STD) such as acquired immune deficiency syndrome (AIDS), condom has been not only the instrument of family planning, also simultaneously to stop sexually transmitted disease (STD) to spread one of effective method, but it is not a kind of airtight latex film, there is the natural crack of latex, the aperture that has the above size of 120nm on latex prophylactic is caused in this crack, and as the instrument of prevention of STD, its success rate can not show a candle to desired.The article report of " health and life " (total the 1245th phase) of on February 27th, 2006 China shows: condom for the success rate of aids prevention 85%, gonorrhea only has 50% left and right, and condyloma acuminatum, because its virion is very little, the success rate of prevention is almost 0.
Human papillomavirus HPV(Human papillomavirus) be that a kind of papillary tumor vacuolating virus A that belongs to papovaviridae belongs to, it is spherical DNA viruses, people is its unique host, HPV is relevant with various diseases, be divided into many hypotypes, to organizing vicious transformation degree difference, can be divided into high-risk-type, middle danger type and low risk three classes by it.HPV is different from other pathogen; its not causing inflammation property reaction; but inspire the propagation of host cell; be tumprigenicity growth, can cause the generation of malignant tumor, as skin carcinoma, carcinoma of tongue etc.; at the end of last century; the chronic infection of having confirmed in the world epithelium of cervix uteri HPV is the cause of disease of cervical cancer, and HPV often can cause the mankind's various warts in addition, as verruca vulgaris, verruca plana, plantar wart, periungual wart and condyloma acuminatum etc.Condyloma acuminatum is one of topmost sexually transmitted disease (STD) of China, has at least 10 types relevant with it, and wherein the most common with HPV6,11 types again, current therapeutic modality is difficult to directly start with from virus, therefore cures the symptoms, not the disease.
Rhizoma Bistortae, for the rhizome of polygonaceae plant Rhizoma Bistortae (Polygonum bistorta L.), be used for the treatment of clinically bacillary dysentery, enteritis, pulmonary tuberculosis, chronic tracheitis, and research is found, Rhizoma Bistortae has obvious analgesic activity, (the Chinese Clinical rehabilitation such as protective effect, DNA cleavage activity to coronary artery injury, 2005,9(6); Time precious traditional Chinese medical science traditional Chinese medicines, 2006,17(6); Chinese herbal medicine, 2003,34(3)).
Chinese invention patent application ZL200510075087.X grafts on interferon on condom, plays antibiosis and antiviral functions.Chinese invention patent ZL200510040025 adds Claritin in condom, solves the problem of part population to condom allergy.But, up to now, not yet find that Rhizoma Bistortae extract has the document that suppresses human papilloma virus toxic action, does not have to be directly used for Rhizoma Bistortae extract as antiviral drugs the report of condom yet.
Summary of the invention
Object of the present invention is intended to overcome the deficiency that condom exists, and a kind of condom with antivirus action is provided, and is realized by the antiviral drugs of adding plant origin in the lubricant of condom.
The preparation method of the condom of antivirus action described in being to provide, another object of the present invention is provided.
According to a first aspect of the invention, a kind of condom with antivirus action, contains Rhizoma Bistortae extract in the lubricant of described condom.
Wherein, described lubricant comprises dimethicone or soluble oil.
Wherein, described Rhizoma Bistortae extract is by extracting Rhizoma Bistortae to make with alcohol heating reflux.Further, described alcohol heating reflux extracts and comprises: with 50% ~ 95% alcohol reflux at least 1 time, and each 1 ~ 4 hour.
According to a second aspect of the invention, the preparation method of described condom comprises: the aqueous solution of Rhizoma Bistortae extract is added in lubricant, stir, then the lubricant that contains Rhizoma Bistortae extract is splashed in condom, to obtain final product.
Wherein, described lubricant comprises dimethicone or soluble oil.
Wherein, described Rhizoma Bistortae extract is by extracting Rhizoma Bistortae to make with alcohol heating reflux.Further, described alcohol heating reflux extracts and comprises: with 50% ~ 95% alcohol reflux at least 1 time, and each 1 ~ 4 hour.
In its lubricant of condom of the present invention, the preferred content of Rhizoma Bistortae extract is 0.001% ~ 90%, is weight percentage; Preferred content is 0.1% ~ 10%.Medicament contg in every condom lubricant is 0.4mg ~ 40mg.
Beneficial effect of the present invention: find in the application's research, apply Rhizoma Bistortae extract prepared by extracting method of the present invention HPV6/11 is had to stronger inhibitory action, illustrate that Rhizoma Bistortae extract of the present invention has good antivirus action, can be used for preparing antiviral condom, can stop from source the propagation of the sexually transmitted disease (STD)s such as the condyloma acuminatum being caused by HPV virus, be with a wide range of applications.
The specific embodiment
Below in conjunction with specific embodiment, the invention will be further described.Should be understood that following examples are only for the present invention is described but not for limiting scope of the present invention.
The Rhizoma Bistortae using in following examples has commercially available.
embodiment 1, Rhizoma Bistortae extract preparation
Take Rhizoma Bistortae medicinal material coarse powder appropriate, add 10 times of amount 70% alcohol reflux 3 times, 2h/ time, filter, merging filtrate, filtrate decompression is concentrated into respect to containing crude drug amount 1g/ml, and concentrated solution is diluted with water to and is equivalent to, containing crude drug amount 0.25g/ml, stir, hold over night, the centrifugal supernatant that obtains, supernatant is evaporated to extractum, and extractum lyophilization obtains Rhizoma Bistortae extract (wherein content of tannin 40%).
embodiment 2, the inhibitory action of Rhizoma Bistortae extract to HPV6/11 type virus
Experiment material:
HPV6/11 type viral source: HPV6,11 type viruses are taken from the wart body of untreated Condyloma acuminatum, grind to form tissue homogenate for subsequent use after normal saline cleans under aseptic condition.
Tested medicine: Rhizoma Bistortae extract (sample prepared by embodiment 1), be dissolved in DMSO, be prepared into 60mg/mL mother solution.
Key instrument: ABI7500 quantitative real time PCR Instrument.
HPV6/11 type FQ-PCR diagnostic kit: Da'an Gene Company, Zhongshan University.
Experimental technique:
Get Condyloma Acuminata homogenate 100 μ L, add tested medicine 10 μ L, control tube adds normal saline 10uL, feminine gender and positive control pipe are established in each experiment simultaneously, hatch for 37 ℃ and (in time gradient experiment, respectively hatch 5 minutes 10 minutes in 20 hours, 15 minutes, 30 minutes, 60 minutes).
Press kit method and extract DNA, get 2 μ L and add in reaction tube, put into ABI7500 quantitative real time PCR Instrument and react, quantitative result, by computer software automatic analysis, calculates its initial copy number.
Experimental result is as shown in following table 1 and table 2.
Table 1, the inhibitory action of Rhizoma Bistortae extract to HPV6/11 type virus
The experimental result of above table 1 shows, the Rhizoma Bistortae extract effect of 25 μ g/mL is after 20 hours, HPV6/11 virus is examined and is not measured, and blank pipe has the very HPV6/11 virus quantity of high concentration, illustrate that Rhizoma Bistortae extract has the effect of well killing HPV6/11 virus, and this action effect is dose-dependent effect.
The time-dependent effect that table 2, Rhizoma Bistortae extract suppress HPV6/11 virus
The experimental result of above table 2 shows, Rhizoma Bistortae extract, under the concentration of 25 μ g/mL, can be killed HPV6/11 virus in 5 minutes completely.
embodiment 3, containing the preparation of the anti-HPV condom of Rhizoma Bistortae extract
It is appropriate that precision takes Rhizoma Bistortae extract, be dissolved in water, slowly add condom with in dimethicone aqueous solution, and add appropriate emulsifying agent (Rhizoma Bistortae aqueous solution, dimethicone and emulsifying agent three addition ratio are 2:7:1), stir, making drug level is 0.1%, and pastille silicone oil is splashed in condom, to obtain final product.
embodiment 4, containing the preparation of the anti-HPV condom of Rhizoma Bistortae extract
It is appropriate that precision takes Rhizoma Bistortae extract, is dissolved in water, and slowly adds condom with in soluble oil aqueous solution, stirs, and making drug level is 0.1%, and pastille lubricant is splashed in condom, to obtain final product.
Before not departing from spirit of the present invention, put, those skilled in the art can be equal to and change and modify it, and described change and modification fall into the coverage of the application's claims equally.
Claims (8)
1. a condom with antivirus action, is characterized in that, in the lubricant of described condom, contains Rhizoma Bistortae extract.
2. condom as claimed in claim 1, is characterized in that, described lubricant comprises dimethicone or soluble oil.
3. condom as claimed in claim 1, is characterized in that, described Rhizoma Bistortae extract is by extracting Rhizoma Bistortae to make with alcohol heating reflux.
4. condom as claimed in claim 3, is characterized in that, described alcohol heating reflux extracts and comprises: with 50% ~ 95% alcohol reflux at least 1 time, and each 1 ~ 4 hour.
5. the preparation method of the condom as described in any one in claim 1-4, is characterized in that, the aqueous solution of Rhizoma Bistortae extract is added in lubricant, stirs, and then the lubricant that contains Rhizoma Bistortae extract is splashed in condom, to obtain final product.
6. preparation method as claimed in claim 5, is characterized in that, described lubricant comprises dimethicone or soluble oil.
7. preparation method as claimed in claim 5, is characterized in that, described Rhizoma Bistortae extract is by extracting Rhizoma Bistortae to make with alcohol heating reflux.
8. preparation method as claimed in claim 7, is characterized in that, described alcohol heating reflux extracts and comprises: with 50% ~ 95% alcohol reflux at least 1 time, and each 1 ~ 4 hour.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210578469.4A CN103892956B (en) | 2012-12-27 | 2012-12-27 | A kind of sheath with antivirus action |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210578469.4A CN103892956B (en) | 2012-12-27 | 2012-12-27 | A kind of sheath with antivirus action |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103892956A true CN103892956A (en) | 2014-07-02 |
| CN103892956B CN103892956B (en) | 2018-10-19 |
Family
ID=50984758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210578469.4A Active CN103892956B (en) | 2012-12-27 | 2012-12-27 | A kind of sheath with antivirus action |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103892956B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105963807A (en) * | 2016-06-21 | 2016-09-28 | 浙江相伴乳胶制品有限公司 | Condom with antisepsis and anti-inflammation functions and preparation method thereof |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4930522A (en) * | 1987-08-20 | 1990-06-05 | Hutchinson | Prophylactic device made of rupturable microencapsulated elastomeric material and process for its manufacture |
| CN1324637A (en) * | 2000-05-22 | 2001-12-05 | 刘克 | Condyloma acuminata treating medicine |
| CN1356143A (en) * | 2002-01-04 | 2002-07-03 | 广州万方健医药有限公司 | Emulsion-type lubricant and its application in medical rubber product |
| US20040133070A1 (en) * | 2003-01-08 | 2004-07-08 | Jerome Lin | Condom device |
| NL1026408C1 (en) * | 2004-06-11 | 2005-12-14 | Hans Peter Anno Rattink | Condom is used for contraception and for avoidance of infection with venereal diseases. It is provided with unrollable ribbons to constitute ease of usage |
| CN1919160A (en) * | 2006-07-25 | 2007-02-28 | 华南师范大学 | Nano antibiotic antiviral condom |
| CN101219156A (en) * | 2007-01-11 | 2008-07-16 | 北京琥珀光华医药科技开发有限公司 | Externally used drug for treating condyloma acuminata and genitalia herpes |
| CN101596131A (en) * | 2009-06-18 | 2009-12-09 | 周政明 | A kind of condom containing antibacterial and antiviral medicine and preparation method thereof |
| CN102327491A (en) * | 2010-12-23 | 2012-01-25 | 陈玉堂 | Medicine for treating venereal diseases, such as prostatosis, condyloma acuminatum, gonorrhea syphilis and aids |
| CN102525720A (en) * | 2010-12-07 | 2012-07-04 | 宁小静 | Condom and manufacture method thereof |
| CN102641169A (en) * | 2012-04-26 | 2012-08-22 | 中南大学 | Condom capable of deactivating microorganism infectivity, and preparation method thereof |
-
2012
- 2012-12-27 CN CN201210578469.4A patent/CN103892956B/en active Active
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4930522A (en) * | 1987-08-20 | 1990-06-05 | Hutchinson | Prophylactic device made of rupturable microencapsulated elastomeric material and process for its manufacture |
| CN1324637A (en) * | 2000-05-22 | 2001-12-05 | 刘克 | Condyloma acuminata treating medicine |
| CN1356143A (en) * | 2002-01-04 | 2002-07-03 | 广州万方健医药有限公司 | Emulsion-type lubricant and its application in medical rubber product |
| US20040133070A1 (en) * | 2003-01-08 | 2004-07-08 | Jerome Lin | Condom device |
| NL1026408C1 (en) * | 2004-06-11 | 2005-12-14 | Hans Peter Anno Rattink | Condom is used for contraception and for avoidance of infection with venereal diseases. It is provided with unrollable ribbons to constitute ease of usage |
| CN1919160A (en) * | 2006-07-25 | 2007-02-28 | 华南师范大学 | Nano antibiotic antiviral condom |
| CN101219156A (en) * | 2007-01-11 | 2008-07-16 | 北京琥珀光华医药科技开发有限公司 | Externally used drug for treating condyloma acuminata and genitalia herpes |
| CN101596131A (en) * | 2009-06-18 | 2009-12-09 | 周政明 | A kind of condom containing antibacterial and antiviral medicine and preparation method thereof |
| CN102525720A (en) * | 2010-12-07 | 2012-07-04 | 宁小静 | Condom and manufacture method thereof |
| CN102327491A (en) * | 2010-12-23 | 2012-01-25 | 陈玉堂 | Medicine for treating venereal diseases, such as prostatosis, condyloma acuminatum, gonorrhea syphilis and aids |
| CN102641169A (en) * | 2012-04-26 | 2012-08-22 | 中南大学 | Condom capable of deactivating microorganism infectivity, and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 梁波等: "中药拳参化学成分及药理活性研究进展", 《甘肃高师学报》 * |
| 谈珍瑜等: "CO2 激光联合中药治疗外阴尖锐湿疣疗效观察", 《中医药学刊》, vol. 24, no. 10, 31 October 2006 (2006-10-31), pages 1951 - 1952 * |
| 郑家欣等: "蒽醌类化合物在蓼科的分布及生物活性研究进展", 《医学导报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105963807A (en) * | 2016-06-21 | 2016-09-28 | 浙江相伴乳胶制品有限公司 | Condom with antisepsis and anti-inflammation functions and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103892956B (en) | 2018-10-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102670588B (en) | Application of ellagic acid to preparation of antiviral medicament | |
| CN103316219B (en) | One treats phthisical Chinese medicine preparation and preparation method thereof | |
| CN104353058B (en) | Pokeweed antiviral protein lyophilized powder complexing agent and preparation method thereof | |
| CN102335223B (en) | Traditional Chinese medicine for treating human papillomavirus infection symptom as well as preparation method and application thereof | |
| CN102085248B (en) | Traditional Chinese medicinal composition for treating cervix diseases, method for preparing same and method for detecting same | |
| Domínguez Gómez et al. | Effectiveness of glycyrrhizinic Acid (glizigen) and an immunostimulant (viusid) to treat anogenital warts | |
| JP2021516696A (en) | Chinese herbal medicine composition, Chinese herbal medicine combination preparation and its preparation method and application | |
| Iljazović et al. | Efficacy in treatment of cervical HRHPV infection by combination of beta interferon, and herbal therapy in woman with different cervical lesions | |
| JP6923147B2 (en) | Chinese herbal medicine composition for treating diseases caused by human papillomavirus, its preparation method and use | |
| CN103892956A (en) | Condom with antiviral effect | |
| CN100558383C (en) | The Chinese medicine of treatment human papilloma virus infection | |
| CN104474148A (en) | Traditional Chinese medicine composition used for treating dermatomycosis and preparation method thereof | |
| CN108042524A (en) | The application of tanshin polyphenolic acid B and its analogue in anti-HPV viruse infection medicine is prepared | |
| CN103599437B (en) | One treats colpitic traditional Chinese medicine liquid | |
| CN113332357A (en) | Composition and preparation for improving cervical HPV infection symptoms and preparation method | |
| CN102138989A (en) | Chinese medicinal ointment for treating scalding, and preparation method and application thereof | |
| Khamjan et al. | Natural and synthetic drugs and formulations for intravaginal HPV clearance | |
| CN105055528A (en) | Traditional Chinese medicine composition self-emulsifying soft capsule used for treating cold, and preparation method thereof | |
| CN103432541A (en) | Novel application of Zingiber mioga bud extractive in blood fat reduction | |
| CN104687032A (en) | Health caring echinacea health product | |
| CN116270940B (en) | Traditional Chinese medicine composition for preventing and treating HPV virus infection as well as preparation method and application thereof | |
| CN103142928A (en) | Iliacus muscle oral liquid and preparation method thereof | |
| CN102512359B (en) | Mangiferin cream with anti-herpes virus effect | |
| CN105920455B (en) | A kind of Chinese materia medica preparation for treating verrucosis | |
| CN105477554A (en) | Medicine for treating HPV infection and preventing cervical cancer and preparation method of medicine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |