CN103892870A - High-frequency ultrasonic device used for diagnosing secretory otitis media - Google Patents

High-frequency ultrasonic device used for diagnosing secretory otitis media Download PDF

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Publication number
CN103892870A
CN103892870A CN201410102756.7A CN201410102756A CN103892870A CN 103892870 A CN103892870 A CN 103892870A CN 201410102756 A CN201410102756 A CN 201410102756A CN 103892870 A CN103892870 A CN 103892870A
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China
Prior art keywords
ultrasonic
receiving circuit
otitis media
diagnosing
high frequency
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Pending
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CN201410102756.7A
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Chinese (zh)
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周盛
王延群
王晓春
计建军
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Institute of Biomedical Engineering of CAMS and PUMC
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Institute of Biomedical Engineering of CAMS and PUMC
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Priority to CN201410102756.7A priority Critical patent/CN103892870A/en
Publication of CN103892870A publication Critical patent/CN103892870A/en
Pending legal-status Critical Current

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Abstract

The invention discloses a high-frequency ultrasonic device used for diagnosing secretory otitis media. The high-frequency ultrasonic device comprises an ultrasonic transducer. A water bag wraps the front end of the ultrasonic transducer. The water bag is filled with water and placed in the external auditory canal, and an ultrasonic beam transmission window is formed between the ultrasonic transducer and the tympanic membrane. An ultrasonic emitting/receiving circuit emits ultrasonic waves to the ultrasonic transducer, the ultrasonic waves act on the tympanic membrane through the water bag, and ultrasonic reflection echoing signals of the tympanic membrane are received by the ultrasonic emitting/receiving circuit through the ultrasonic transducer. The ultrasonic emitting/receiving circuit transmits the ultrasonic reflection echoing signals to a PC through a USB interface. The PC outputs ultrasonic diagnosis results through amplitudes and the number of crests in the ultrasonic reflection echoing signals. By means of the high-frequency ultrasonic device, the secretory otitis media is diagnosed, diagnosis accuracy and sensitivity are improved, and pain of a patient is reduced.

Description

A kind of for diagnosing the high frequency ultrasound device of secretory otitis media
Technical field
The present invention relates to high frequency ultrasound field, relate in particular to a kind of for diagnosing the high frequency ultrasound device of secretory otitis media.
Background technology
Secretory otitis media (OME) is defined as the tympanum hydrops without acute otitis media sings and symptoms, and intratympanic liquid has formed the barrier of sound conduction.Children with otitis media with effusion sickness rate is higher, and a large amount of research datas show have about 80% child all must cross secretory otitis media, most morbidities in the time of 6 months~4 years old.1 year old and within 50%, 2 years old, be increased to 60% with interior morbidity with accounting for of interior morbidity in 1 years old.Part OME patient spontaneous recovery in 3 months, but have 30%~40% child can repeatedly occur secretory otitis media, has 5%~10% infant symptom can continue more than 1 year.Infantile period generation otitis media may cause lifelong impact to infant.First affect the audition of infant, directly impact obtains necessary verbal information in speech growth course, causes sequela, affects patient's quality of life.Because secretory otitis media can be brought very large impact to child's audition and quality of life from now on, therefore in early days, accurately diagnosis have great significance.The diagnosis of secretory otitis media mainly comprises: middle ear effusion after complete tympanum, there is no the medical history of acute attack, simultaneously without symptom and/or the sign of acute otitis media.
Along with the development of modern medicine, the diagnostic method of secretory otitis media becomes all the more variation, and the diagnostic method of clinical practice at present has: air blast otoscope, tympanogram and sound reflecting, ear microendoscopic, the methods such as auripuncture or otomy.Although these method accuracys are higher, scab at tympanum, thicken, when muddiness or middle ear system motion are lowered, can there is the illusion of liquid, and cause implementing unnecessary myringotomy.Infant otitis media is owing to lacking main suit, and external auditory meatus is narrower in addition subsides, and tympanum tilts, and is grown up thick, haves a medical check-up and mismatches etc., at present this class crowd's otitis media is mainly made to diagnosis according to clinical sings and symptoms.
Summary of the invention
The invention provides that a kind of this high frequency ultrasound device has been realized the diagnosis to secretory otitis media for diagnosing the high frequency ultrasound device of secretory otitis media, and improved accuracy and the sensitivity of diagnosis, described below:
For diagnosing a high frequency ultrasound device for secretory otitis media, described high frequency ultrasound device comprises: ultrasound emission/receiving circuit, ultrasonic transducer, water pocket, USB interface and PC.
The front end of described ultrasonic transducer is enclosed with described water pocket, and described water pocket is full of water and is placed in external auditory meatus, forms the transmissive window of ultrasonic beam between described ultrasonic transducer and tympanum;
Extremely described ultrasonic transducer of described ultrasound emission/receiving circuit transmitting ultrasound wave, and act on described drum by described water pocket
On film, described ultrasound emission/receiving circuit receives the ultrasonic reflection echo-signal of described tympanum by described ultrasonic transducer; Described ultrasound emission/receiving circuit transmits described ultrasonic reflection echo-signal to described PC by described USB interface;
Described PC is by the amplitude in described ultrasonic reflection echo-signal and crest number output ultrasonic diagnosis result.
The ultrasound wave of described ultrasound emission/receiving circuit transmitting is 10MHz tranmitting frequency, the diameter <5mm of described ultrasonic transducer.
Described ultrasonic transducer and described water pocket composition probe, is characterized in that, adopts hose connection between described probe and described ultrasound emission/receiving circuit.
Radiating circuit in described ultrasound emission/receiving circuit adopts N & P double channel high speed MOSFET pipe, is all less than time delay, rise time, turn-off delay time and fall time 20ns.
Receiving circuit in described ultrasound emission/receiving circuit is chosen low-noise amplifier ad4899-1 and variable gain amplifier ad8331.
A/D convertor circuit in described ultrasound emission/receiving circuit adopts the high-speed AD chip of 120MHz.
The fpga chip of described ultrasonic echo Digital Signal Processing based on altera corp.
Described USB interface chip adopts the 68013A of cypress company.
The beneficial effect of technical scheme provided by the invention is: ultrasound emission/receiving circuit gathers the ultrasonic reflection echo-signal of tympanum, and this ultrasonic reflection echo-signal is converted to digital data transmission to PC, PC is by identification amplitude and crest number output ultrasonic diagnosis result wherein, realized the diagnosis to secretory otitis media by this high frequency ultrasound device, and improve accuracy and the sensitivity of diagnosis, reduced patient's misery.
Brief description of the drawings
Fig. 1 is a kind of for diagnosing the structural representation of high frequency ultrasound device of secretory otitis media;
Fig. 2 is test principle figure.
In accompanying drawing, the list of parts of each label representative is as follows:
1: ultrasound emission/receiving circuit; 2; Ultrasonic transducer;
3: water pocket; 4:USB interface;
5:PC machine; 6: tympanum.
Detailed description of the invention
For making the object, technical solutions and advantages of the present invention clearer, below embodiment of the present invention is described further in detail.
High-frequency ultrasonic imaging is a kind of diagnostic means of safety and precise, is widely used in medical profession.But but few people are applied in ultrasonic diagnosis in the inspection of middle ear.Diagnose without too much patient and coordinate by high frequency ultrasound, can not cause pain and traumatic to infant, and have important Research Significance for improving diagnostic sensitivity and specificity.
In order to realize the diagnosis to secretory otitis media, and improve accuracy and the sensitivity of diagnosis, it is a kind of for diagnosing the high frequency ultrasound device of secretory otitis media that the embodiment of the present invention provides, referring to Fig. 1, this high frequency ultrasound device comprises: ultrasound emission/receiving circuit 1, ultrasonic transducer 2, water pocket 3, USB interface 4 and PC 5
Wherein, the front end of ultrasonic transducer 2 is enclosed with the water pocket 3 of sleeve configuration, and in the time that needs detect, water pocket 3 is full of water and is placed in external auditory meatus, has formed like this transmissive window of ultrasonic beam between ultrasonic transducer 2 and tympanum 6.Ultrasound emission/receiving circuit 1 is launched ultrasound wave to ultrasonic transducer 2, and acts on tympanum 6 by water pocket 3, and ultrasound emission/receiving circuit 1 receives the ultrasonic reflection echo-signal of tympanum 6 by ultrasonic transducer 2; Ultrasound emission/receiving circuit 1 transmits ultrasonic reflection echo-signal to PC 5 by USB interface 4, and PC 5 is by the amplitude in ultrasonic reflection echo-signal and crest number output ultrasonic diagnosis result.
When practical application, gently draw auricle under backward, stretch auditory meatus, make ultrasound wave direct projection tympanum 6.The structure of middle ear is an airtight aerated space, and except a side is tympanum 6, all the other chamber walls are sclerotin, and under normal condition, in the time that ultrasound wave is surveyed middle ear by external auditory meatus, the interference of gas is all reflected sound wave, and tympanum structure cannot be surveyed.If middle ear have been infected inflammation, will after tympanum 6, there is a certain amount of liquid.Judge whether to exist hydrops by amplitude and the crest number of measuring ultrasonic reflection echo-signal.In the time there is middle ear effusion, because liquid is to hyperacoustic energy absorption, the peak value that tympanum 6 reflects will reduce.When there is (tympanum 6 and middle ear intermedium wall) when two reflection echos, in explanation, in ear is full of hydrops, occurs a reflection echo, and amplitude is when higher (only from membrana tympani reflex), shows that middle in ear is without hydrops, as shown in Figure 2.
Wherein, the ultrasound wave that ultrasound emission/receiving circuit 1 is launched adopts 10MHz tranmitting frequency, the diameter <5mm of ultrasonic transducer 2.In testing process, the front end parcel water pocket 3 of ultrasonic transducer 2, contact tympanum 6 is measured, to alleviate human body sense of discomfort.Ultrasonic transducer 2 and water pocket 3 composition probes, adopt hose type design between probe and ultrasound emission/receiving circuit 1, make probe can free in and out human body external auditory meatus, is convenient to measure.
Radiating circuit in ultrasound emission/receiving circuit 1 adopts N & P double channel high speed MOSFET pipe, can produce bipolar pulse sequence, supply voltage ± 12V; Logical time delay of the t of high speed MOSFET pipe d (on), rise time t r, turn-off delay time t d (off)with t fall time fall be less than 20ns, and reach certain rated power, guarantee that tranmitting frequency reaches 10MHz.
Receiving circuit in ultrasound emission/receiving circuit 1 is chosen low-noise amplifier ad4899-1 and variable gain amplifier
Ad8331 improvement pre-amplification circuit structure, makes its frequency band reach the requirement of 10MHz, and overall gain is more than 65dB, and variable gain scope reaches 40dB, and realizes time gain control according to the difference of investigation depth.
In medical ultrasonic Digital Signal Processing, for guaranteeing to be converted to by analogue signal the accuracy of data in digital signal processes, the sample frequency of General Requirements data reaches the more than 8 times of signal frequency, thereby suppressed sidelobes improves accuracy of detection.In design, A/D convertor circuit in ultrasound emission/receiving circuit 1 is adopted to the high-speed AD chip of the highest 120MHz and in conjunction with peripheral circuit, the ultrasound echo signal of Obtaining Accurate 10MHz.
Utilize mass storage and the powerful data-handling capacity of existing PC, digital ultrasonic reflection echo-signal is carried out on PC 5 to real-time Transmission and processing by USB interface 4, not only greatly facilitate diagnostic procedure, and be conducive to the storage of data and the raising of diagnostic reliability; This platform receives digital ultrasonic reflection echo-signal on the one hand, on the other hand by this signal real-time Transmission on PC 5.USB interface 4 adopts the 68013A of cypress company, and programming language comprises Verilog and C language.
The embodiment of the present invention to the model of each device except do specified otherwise, the model of other devices does not limit, and all can as long as can complete the device of above-mentioned functions.
It will be appreciated by those skilled in the art that accompanying drawing is the schematic diagram of a preferred embodiment, the invention described above embodiment sequence number, just to describing, does not represent the quality of embodiment.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.

Claims (8)

1. for diagnosing a high frequency ultrasound device for secretory otitis media, it is characterized in that, described high frequency ultrasound device comprises: ultrasound emission/receiving circuit, ultrasonic transducer, water pocket, USB interface and PC,
The front end of described ultrasonic transducer is enclosed with described water pocket, and described water pocket is full of water and is placed in external auditory meatus, forms the transmissive window of ultrasonic beam between described ultrasonic transducer and tympanum;
Extremely described ultrasonic transducer of described ultrasound emission/receiving circuit transmitting ultrasound wave, and act on described tympanum by described water pocket, described ultrasound emission/receiving circuit receives the ultrasonic reflection echo-signal of described tympanum by described ultrasonic transducer; Described ultrasound emission/receiving circuit transmits described ultrasonic reflection echo-signal to described PC by described USB interface;
Described PC is by the amplitude in described ultrasonic reflection echo-signal and crest number output ultrasonic diagnosis result.
2. according to claim 1 a kind ofly it is characterized in that for diagnosing the high frequency ultrasound device of secretory otitis media, the ultrasound wave of described ultrasound emission/receiving circuit transmitting is 10MHz tranmitting frequency, the diameter <5mm of described ultrasonic transducer.
3. according to claim 1 a kind of for diagnosing the high frequency ultrasound device of secretory otitis media, described ultrasonic transducer and described water pocket composition probe, is characterized in that, adopts hose connection between described probe and described ultrasound emission/receiving circuit.
4. a kind of for diagnosing the high frequency ultrasound device of secretory otitis media according to described in arbitrary claim in claim 1-3, it is characterized in that, radiating circuit in described ultrasound emission/receiving circuit adopts N & P double channel high speed MOSFET pipe, is all less than time delay, rise time, turn-off delay time and fall time 20ns.
5. a kind of for diagnosing the high frequency ultrasound device of secretory otitis media according to described in arbitrary claim in claim 1-3, it is characterized in that, the receiving circuit in described ultrasound emission/receiving circuit is chosen low-noise amplifier ad4899-1 and variable gain amplifier ad8331.
6. it is characterized in that for diagnosing the high frequency ultrasound device of secretory otitis media according to a kind of described in arbitrary claim in claim 1-3, the A/D convertor circuit in described ultrasound emission/receiving circuit adopts the high-speed AD chip of 120MHz.
7. it is characterized in that the fpga chip of described ultrasonic echo Digital Signal Processing based on altera corp for diagnosing the high frequency ultrasound device of secretory otitis media according to a kind of described in arbitrary claim in claim 1.
8. it is characterized in that for diagnosing the high frequency ultrasound device of secretory otitis media according to a kind of described in arbitrary claim in claim 1, described USB interface chip adopts the 68013A of cypress company.
CN201410102756.7A 2014-03-19 2014-03-19 High-frequency ultrasonic device used for diagnosing secretory otitis media Pending CN103892870A (en)

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CN104107082A (en) * 2014-07-28 2014-10-22 无锡市贝尔康电子研究所 Superconductive visible bionic instrument capable of accurately controlling expansion of water sac

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CN102283680A (en) * 2011-05-18 2011-12-21 中国医学科学院生物医学工程研究所 Cataract crystalline lens hardness ultrasonic measurement system
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Publication number Priority date Publication date Assignee Title
CN104107082A (en) * 2014-07-28 2014-10-22 无锡市贝尔康电子研究所 Superconductive visible bionic instrument capable of accurately controlling expansion of water sac

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Application publication date: 20140702