CN103877591A - Auxiliary material capable of improving quality of traditional Chinese medicine gelatin and gelatin product produced together with auxiliary material in matching manner - Google Patents
Auxiliary material capable of improving quality of traditional Chinese medicine gelatin and gelatin product produced together with auxiliary material in matching manner Download PDFInfo
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Abstract
The invention relates to an auxiliary material capable of improving quality of a traditional Chinese medicine gelatin and a gelatin product produced with the auxiliary material together in a matching manner, belongs to the traditional Chinese medicine industry, and in particular belongs to the auxiliary material field in the traditional Chinese medicine preparation industry. The donkey-hide gelatin is greasy, which is a hindrance to the digestive functions of the spleen and the stomach; the smell of the donkey-hide gelatin cannot be borne by multiple users (other gelatins are more terrible in smell), which directly influences the eating of the users; the donkey-hide gelatin mostly contains protein ingredients, so that the donkey-hide gelatin is easy to deteriorate and mildew; and all the gelatins have one significant defect which cannot be overcome until now, namely, the gelatins are difficult to accept because being terrible in smell, and are easy to mildew because of being high in protein content. In order to solve the problems of the existing gelatins, according to a method provided by the invention, litsea cubeba ingredients or/and perilla ingredients or/and walnut ingredients are added during the production of the traditional Chinese medicine gelatin so as to serve as the auxiliary material for replacing soybean oil or rice wine; and generally, litsea cubeba oil, perilla oil or walnut oil is used for replacing the soybean oil or the rice wine, so that the quality and the storage life of the traditional Chinese medicine gelatin are obviously improved; the taste of the traditional Chinese medicine gelatin is improved; and the terrible smell of the traditional Chinese medicine gelatin is eliminated.
Description
Technical field
The invention belongs to Chinese herbal medicine industry, especially belong to the adjuvant field in Chinese medicine manufacturing industry.
Background technology
Especially taking animal skins or bone, first, angle as raw material, extract colloid, add adjuvant, be condensed into thick glue shape, the interior oral solid Chinese medicine colloid of making after drying or the liquid Chinese medicine colloid for oral administration of not making after drying, typically refer to hide glue class, as Colla Corii Asini, gelatinum oxhide etc.; Angle glue class: as Colla cornus cervi; Osseocolla class: osseocolla system tempers and forms with the skeleton of animal, typically refers in the past Colla Os Tigris, along with carrying out of relevant environmental protection ban, now most of alternative with dog bone glue; Nail gelatin class: temper and form with the carapace of Testudinis or its nearly edge animal or web, as Colla Plastri Testudinis, Colla carapax Trionycis etc.; Other glue classes: all animal drugs that contains protein, temper through decocting, generally all can be made into colloid, as with beef through tempering the colloid that forms, jointly tempering the turtle and deer glue forming, the epoxy glue mixing with Colla Plastri Testudinis and Colla cornus cervi taking Carapax et Plastrum Testudinis and Cornu Cervi as raw material.
Under " Pharmacopoeia of People's Republic of China (version in 2010) " Colla Corii Asini item, specify: " donkey skin is soaked to unhairing; stripping and slicing is cleaned; gradation decocting; filter, merging filtrate, concentrated (can add respectively appropriate yellow wine, crystal sugar and Oleum Glycines) is to thick paste shape; condensation; stripping and slicing, dries, and to obtain final product." this shows, in the production of Colla Corii Asini, adding adjuvant is not the Compulsory Feature of pharmacopeia, each Colla Corii Asini manufacturing enterprise can grasp according to the situation of self.That is to say, Chinese Pharmacopoeia specifies the production of Colla Corii Asini, allows " adding the Colla Corii Asini of adjuvant " and " not adding the Colla Corii Asini of adjuvant " two kinds, but at present, the Colla Corii Asini major part of seeing on the market adds appropriate adjuvant to produce.According to the needs of technique, Colla Corii Asini often adds the adjuvants such as crystal sugar, Oleum Glycines, yellow wine in process of production.The effect of the existing taste masking of adjuvant and assistant formation, also has certain medical assosting effect.
In Colla Corii Asini manufacture, use the effect of Oleum Glycines: add Oleum Glycines can reduce the viscosity of glue, be convenient to stripping and slicing; In the time of concentrated receipts glue, the easy loss of bubble in pot; Protection film is not cracked.In drying in the air of Colla Corii Asini process processed, oils forms oil reservoir on the surface of film, and then plays the not cracked effect of protection film.
In Colla Corii Asini manufacture, use the effect of yellow wine: the object that adds yellow wine is mainly to rectify smelly taste masking.Shaoxing rice wine fragrant odour, can improve the abnormal smells from the patient of Colla Corii Asini.Colla Corii Asini adds after drinks, and in glue concentration and evaporation process, in glue, volatile odor causing substance can distribute in various degree, thereby reaches the object of taste masking.
Colla Corii Asini adds Oleum Glycines in producing and yellow wine is the important adjuvant in traditional handicraft, and adding Oleum Glycines is for technological operation and molding; To add yellow wine be for taste masking and improve the abnormal smells from the patient of Colla Corii Asini.
According to the statement of Chinese Pharmacopoeia, illustrate that it is not Compulsory Feature that Colla Corii Asini adds Oleum Glycines and yellow wine in production process, this just explanation can to allow Colla Corii Asini manufacturing enterprise use can be object and use separately the succedaneum of yellow wine and Oleum Glycines based on improving Colla Corii Asini performance.
Especially, Colla Corii Asini is grown greasy, hinders digestive function of spleen and stomach; The abnormal smells from the patient of Colla Corii Asini makes many eaters feel directly affects unpleasant (abnormal smells from the patient of other colloid is more added with one niff) and takes; Because Colla Corii Asini composition major part is protein composition, be easy to cause Colla Corii Asini to go bad and mildew.
It is basic similar to Colla Corii Asini for the adjuvant regulation using in production process that other is documented in Chinese medicine glue preparation (colloid) in Chinese Pharmacopoeia, all there is no Compulsory Feature.
All colloids all have a major defect still facing so far: because the smell is awful, impact is taken; Because protein content is high, easily mildew.
Therefore, be necessary to work out a kind of adjuvant and relevant supporting technology that can solve Chinese medicine colloid the problems referred to above.
Summary of the invention
the object of the invention:
Be to provide a kind of Chinese medicine colloid adjuvant and support the use method, and the Chinese medicine colloid product that uses this matching method to produce, especially:
Be to provide a kind of contain Fructus Litseae or/and Folium Perillae composition or/and the Chinese medicine colloid (Colla Corii Asini) of Semen Juglandis composition and the technology that forms a complete production network thereof.
realize the technical scheme of goal of the invention
1. taking animal skins or bone, first, angle as raw material, extract colloid, add adjuvant, be condensed into thick glue shape, the solid-state Chinese medicine colloid of making after drying; Or taking animal skins or bone, first, angle as raw material, extract colloid, add adjuvant, be condensed into thick glue shape, the liquid Chinese medicine colloid of not making after drying; Or/and add the oral Chinese medicine colloid of making after adjuvant during with the deep processing of finished product Chinese medicine colloid.Key technology is described " adjuvant ", refers to and wherein contains or comprise or just refer to: Fructus Litseae composition or/and Folium Perillae composition or/and Semen Juglandis composition.Method can be decomposed into:
2. the present invention is expressed as with another kind: taking animal skins or bone, first, angle as raw material, extract colloid, add adjuvant, be condensed into thick glue shape, make after drying in the process of solid-state Chinese medicine colloid and add adjuvant; Or taking animal skins or bone, first, angle as raw material, extract colloid, add adjuvant, be condensed into thick glue shape, do not make after drying in the process of liquid Chinese medicine colloid and add adjuvant; Or with adding adjuvant in finished product Chinese medicine colloid deep-processing process, its key point is contain or comprise or just refer in described " adjuvant ": Fructus Litseae composition or/and Folium Perillae composition or/and Semen Juglandis composition.Adding method can be decomposed into:
. use Fructus Litseae composition or/and Folium Perillae composition in the production process of Chinese medicine colloid, the Oleum Glycines class adjuvant that part substitutes or replacing whole Chinese medicine colloid uses in manufacturing; Or
The use flow process of Fructus Litseae composition, Folium Perillae composition, Semen Juglandis composition, can be the same with the flow process of use Oleum Glycines, yellow wine, also can use in advance than the use flow process of Oleum Glycines, yellow wine, and use also can lag behind.
3. in the time that Chinese medicine colloid is carried out to deep processing, in Chinese medicine colloid (as Colla Corii Asini) carries out deep-processing process, add adjuvant Fructus Litseae composition or/and Folium Perillae composition or and Semen Juglandis composition, allow contain Fructus Litseae composition in the finely processed product of Chinese medicine colloid or/and Folium Perillae composition or/and Semen Juglandis composition.
4. copy fruit wine technique to make Fructus Litseae fruit wine, perilla fruit wine, Semen Juglandis fruit wine Fructus Litseae, Fructus Perillae stem and leaf, Semen Juglandis, alcoholic strength is adjusted in to 10-30%, be used in the production of Chinese medicine colloid by above-mentioned 1-3 point methods.Fructus Litseae fruit wine, perilla fruit wine, Semen Juglandis fruit wine can substitute yellow wine wholly or in part.
5. with any one or two kinds of in Fructus Litseae, Fructus Perillae stem and leaf, Semen Juglandis three or all for primary raw material, after copying microorganism fermentation oils and fats technology fermentation process, squeeze the liquid after its fermentation of leaching, be used in the production of Chinese medicine colloid by above-mentioned 1-3 point methods.
6. the liquid that said method 5 and method 4 can be prepared is the part or all of yellow wine in even rear alternative Chinese medicine colloid by a certain percentage, or part or all of Oleum Glycines.
beneficial effect
By Fructus Litseae or/and Folium Perillae edible composition be used in Chinese medicine colloid produce in can produce following effect: finished product colloid is had to good flavouring and antisepsis, add aborning after Fructus Litseae, can effectively remove some bad smell in Chinese medicine colloid, increase one natural fragrance (conventionally can increase a kind of natural lemon perfume (or spice) of feeling more happy of making us).The theoretical basis of this is:
in Fructus Litseae plant, especially in litsea cubeba oil, contain: citral a (geranial Citrala), this material has a kind of natural citris aromas; Citral b (neral b-citral), in having citris aromas, also has a kind of natural fragrance; Methyl heptenone (methyl – heptenone), has fresh QINGXIANG, Citrus sample gas breath; Citronellal (Citronellal), has and has Fructus Citri Limoniae, Bulbus Lilii, Flos Rosae Rugosae fragrance; Australene (α-pinen) has the advantages that fragrance is sent out thoroughly; Hesperidene (limonene), has special fragrance; Linalool (Linalool), has with sweet MUQING breath, like rose wood; Geraniol (Geraniol), has gentleness, sweet Flos Rosae Rugosae breath; Nerol (cis-3,7-Dimethyl-2,6-octadienol, Nerol, Vernol, Lorena), these materials all have the fragrance of pleasant Flos Rosae Rugosae and orange blossom, fragrance is more gentle, micro-fruital with Fructus Citri Limoniae sample, nerol is the isomer of geraniol, its fragrance is than the soft grace of geraniol, relatively partially clear, and with fresh delicate fragrance and Citrus aromatic.Litsea cubeba oil has fresh Lemon fruit fragrance.The boiling point of the material of the natural fragrance of these tools and flash-point just in time can meet the object that regulates Chinese medicine colloid mouthfeel and abnormal smells from the patient.
Folium Perillae can be removed " smell of mutton " principle in Chinese medicine glue preparation, just can make clear by a very simple reason: the principle that the Folium Perillae of knowing with people can be removed the fishlike smell in fish Eriocheir sinensis food is similar.
Common Oleum Glycines, Oleum Arachidis hypogaeae semen, Oleum Sesami just cannot produce the effect of the grey oil in mountain, Folium Perillae oils for Colla Corii Asini and other colloid manufacture.
In the time that above-mentioned two Matter Compositions add in Chinese medicine glue system, just in time can remove or cover in glue preparation and to allow people be difficult to the abnormal smells from the patient of accepting originally, and can significantly improve the mouthfeel of colloid, can also allow in colloid and increase a kind of natural pleasant fragrance.
2. because Fructus Litseae and Folium perillae extract all have antibacterial, anti-microbial property, common Oleum Glycines, Oleum Arachidis hypogaeae semen, Oleum Sesami just do not possess this antibacterial, anti-microbial property.
The 21st the 1st phase of volume " fine chemistry industry magazine " of January in 2004 is loaded with " research of Antibacterial Activity of Perilla Frutescens " document and finds: " this institute is found to contain antimicrobial component in Folium Perillae hot water being engaged in Folium Perillae pigment research ... find petroleum extract and the Folium Perillae of Folium Perillae, stem, the acetic acid ethyl ester extract of root represents that to staphylococcus aureus and escherichia coli etc. bacterium has antibacterial activity ... experiment shows: Antibacterial Constituents of Perilla frutescens mainly concentrates on volatile oil, flavone, phenol, organic acid, the compounds such as tonkabean lactone.”
The 13rd the 4th phase of volume of August in 1998 " Chinese grain and oil journal " is loaded with " the anti-mildew fresh-keeping effect of litsea cubeba oil to peanut butter " document and finds: " adopt flat band method comparison litsea cubeba oil and fabricated food antiseptic to comprise to 5 kinds of mycetes the antibacterial efficacy that causes the rotten mycete of peanut butter.Result shows: in the time of culture medium PH5.5, litsea cubeba oil is 1.77mg/ml to the minimum inhibitory concentration of most mycetes, and sodium benzoate is 3.10mg/ml., from litsea cubeba oil and Aspergillus flavus produce the test of malicious relation, find, litsea cubeba oil produces aflatoxin to Aspergillus flavus stronger bacteriostasis meanwhile.In the beerwort shaking table of Lu Shi yeast is cultivated, the grey oil in mountain of interpolation 0.10% can change its growth curve, the phase of adjustment of making, extends, and exponential phase and stable phase shorten, and have reduced by 55% total cellular score.”
Other Research Literature is also studied and is shown, litsea cubeba oil all has stronger antibacterial action to multiple mycetes such as Aspergillus flavus, Aspergillus citrimum, Mucor racemosus Fres, Rhizopus oryzaes.
The present invention is subject to the inspiration of above-mentioned document, in the technology of the present invention, must measure 0.1% to 2% use litsea cubeba oil by virgin rubber or/and when 0.5% to 5% perilla oil, with do not use the grey oil in mountain or/and the finished product of perilla oil compares result: the glue preparation finished product fungi count that adds litsea cubeba oil is few more than 15%, along with the increase of litsea cubeba oil consumption, fungistatic effect improves thereupon, can significantly improve the shelf-life of colloid; Add the colloid of perilla oil, compare with the reference substance that does not use non-the inventive method of perilla oil to produce, the glue preparation finished product fungi count that adds perilla oil is few more than 10%, also along with the increase of perilla oil consumption, fungistatic effect improves thereupon, can significantly improve the shelf-life of colloid; Must measure 2% use by virgin rubber after litsea cubeba oil is coordinated in 1 to 2 ratio with perilla oil time, finished product fungi count is few more than 20%, has the trend thereupon improving along with the increase fungistatic effect of use amount.
---illustrate that the technology of the present invention can significantly improve the shelf-life of Chinese medicine colloid.Testing method is with reference to conventional method.
Due to theory of Chinese medical science and among the peoplely have a kind of viewpoint, the Colla Corii Asini that effect of old Colla Corii Asini is better than newly going out, adopts the harmful microorganism content of the old Colla Corii Asini of the technology of the present invention control to equal to improve the quality of Colla Corii Asini, equals especially to have improved the commodity class of Colla Corii Asini.
3. gained Colla Corii Asini of the present invention and reference substance Colla Corii Asini (being not use Fructus Litseae, Folium Perillae composition person in production process) are carried out to sense organ relative analysis with reference to the method for pointing out as Publication about Document:
" GB 12316-1990 sensory testing methods " A "-" non-A " inspection ";
Emphasis adopts describes assessment method.Because Colla Corii Asini is food and medicine, thus adopt relevant subjective appreciation method be can be suitable for of the present invention.
Evaluation result is as follows:
4. produce the workshop of Chinese medicine colloid because of the very easily rotten corruption of protein in raw material, the even whole Production Regional of workshop is very easily being filled the air one hide glue stink around, use after the technology of the present invention, because Fructus Litseae and Folium Perillae all have extremely strong antibacterial effectiveness and natural fragranced, thereby can reduce or cover airborne stink more than 30%.This is the contribution that the present invention improves production environment.
5. Chinese Patent Application No. 031178022 discloses a kind of " litsea cubeba oil is as the application of anti-candida infection medicine " patent of invention, illustrates that litsea cubeba oil has good anti-candida effect.And women is monilial infection susceptible colony, just in time Colla Corii Asini class colloid is again the food (medicine) that the informal dress of women colony is used, in Colla Corii Asini manufacture, add and use Fructus Litseae composition, can make Colla Corii Asini possess certain anti-candida infects, equaled to widen the medicinal scope of Colla Corii Asini, this is also a marked improvement feature of the present invention.
6. partly or entirely substitute after Oleum Glycines with the composition of Fructus Litseae, Folium Perillae, Semen Juglandis, can reduce equally the viscosity of glue, be convenient to stripping and slicing; In the time of concentrated receipts glue, the easy loss of bubble in pot; Protection film is not cracked.In drying in the air of Colla Corii Asini process processed, oils can form oil reservoir (eigen effect is especially obvious when using perilla oil, walnut oil) equally on the surface of film, and then plays the not cracked effect of protection film.
Especially have document to show that Fructus Litseae seed contains fatty about 30-40%, this fatty oil has important surfactant properties, can directly manufacture soap, and therefore characteristic can reduce the viscosity of glue too; The fatty characteristic of Fructus Litseae also has a kind of function: can use and even not use Alumen material conventional in glue less, thereby can effectively control Alumen content, to improve the quality of glue.
7. show according to contained " fatty acid composition, content of vitamin E and the physicochemical property research of perilla oil " of the 34th the 12nd phase of volume " Northwest Agricultural University's journal " (natural science edition) of December in 2006: in perilla oil, the total content of vitamin E is 500.9mg/kg, all higher than the content of vitamin E in the oils and fatss such as Oleum Arachidis hypogaeae semen (165.5 mg/kg), almond oil (355.3 mg/kg), Oleum Brassicae campestris (151.5 mg/kg), Amygdalus communis Lamarck oil (294.8 mg/kg)." other document shows that the content of vitamin E of Oleum Glycines is 350 mg/kg.---Oleum Glycines is manufactured adjuvant as the Colla Corii Asini of recommending in Chinese Pharmacopoeia, but its vitamin content is no more than Folium Perillae innage, in the present invention, substitute after Oleum Glycines with perilla oil, equal to improve the content of vitamin E in Colla Corii Asini, the raising of natural Vitamin E content, being on record for women's effect, is exactly the raising because of content of vitamin E in Colla Corii Asini in addition, can significantly improve the antioxidation of goods.---this is a marked feature of the present invention.
8. Folium Perillae is a kind of medicine and a kind of food, illustrates that its safety is quite high, and it is added in Chinese medicine colloid without any side effects; Litsea cubeba oil, equally as food additive, also proves that its safety can meet the needs that Chinese medicine colloid is produced completely.
9. Colla Corii Asini class Chinese medicine colloid affects user's digestion and absorption because having one " greasy property ", even causes user to vomit.
Modern study document shows: Folium Perillae composition has preventing or arresting vomiting effect; Chinese classical document " Bencao Tujing " states clearly Folium Perillae: logical heart channel, strengthening the spleen stomach.
There is literature research to show the litsea cubeba oil effect that can stimulate digestion, alleviate the sensation of flatulence and regurgitation, can also whet the appetite.
Utilize these property of medicine of Folium Perillae and Fructus Litseae, the absorption level of raising colloid that can be complementary in the time that it contains in Colla Corii Asini class colloid in human body, has remarkable effect for " the greasy property " that reduce Colla Corii Asini.
Because of in Chinese Pharmacopoeia for supplementary product kind in Chinese medicine colloid (Colla Corii Asini) and whether need to add and do not make Compulsory Feature, add that Folium Perillae and litsea cubeba oil, walnut oil and their seed all can be directly as food or food additive, so the adjuvant that the technology of the present invention is addressed applies in Colla Corii Asini class Chinese medicine colloid, can not cause administration examination & approval obstacle.
11. Semen Juglandiss have the king's of BAIGUO good reputation, and nutrition and its health properties are well-known.With after the alternative or partly alternative Oleum Glycines of walnut oil, can strengthen nutritive value and nutrient substance in Chinese medicine colloid.If alone walnut oil substitutes Oleum Glycines and mismatches use litsea cubeba oil, having a problem is the shelf-life that can affect colloid, reason is because walnut oil is easily oxidized and causes the shelf-life of colloid influenced, be added with after Fructus Litseae composition, the oxidation resistance of colloid can be effectively strengthened, the oxidation factor causing because containing high nutrient walnut oil can be effectively resisted.When Folium Perillae composition and walnut oil are used in conjunction with in the time that Chinese medicine colloid is produced, also have good antioxidation and ensure the Chinese medicine colloid shelf-life of containing Semen Juglandis composition, but experiment shows: the oxidation resistance of Folium Perillae composition is weaker than litsea cubeba oil.
12. use walnut oils substitute or part substitutes after Oleum Glycines, can strengthen nutritive value and nutrient substance in Chinese medicine colloid, Semen Juglandis has important health-care effect for women and elderly and infirm, Semen Juglandis composition is produced and coordinated production with colloid, produce a kind of Chinese medicine colloid that contains Semen Juglandis composition, can strengthen greatly the power of influence of Colla Corii Asini class colloid on market, be about to the marketing activity of Colla Corii Asini series products to produce significant effect.
13. use Fructus Litseae fruit wine, perilla fruit wine, Semen Juglandis fruit wine substitute after rice wine production Chinese medicine colloid, taste masking effect compares according to the assessment method of the present invention's prompting, and the Colla Corii Asini that uses Fructus Litseae fruit wine, perilla fruit wine, the alternative yellow wine of Semen Juglandis fruit wine to make uses the Colla Corii Asini that yellow wine is adjuvant person can improve more than 15% in taste masking effect.
14. utilize after microorganism fermentation oils and fats technical finesse Fructus Litseae, Folium Perillae, Semen Juglandis, except improving the oil yield of these materials, can also increase some health-care components in these oil, especially can select as required corresponding strain to ferment, to expand the functional area of Chinese medicine colloid, because Colla Corii Asini class Chinese medicine was exactly a kind of taking health care as main material originally, the function of expanding Colla Corii Asini by changing production auxiliary materials composition is also one of a kind of feasible way.
In sum, the present invention has significant progressive technically.
Detailed description of the invention
Taking animal skins or bone, first, angle as raw material, extract colloid, add adjuvant, be condensed into thick glue shape, make after drying solid-state Chinese medicine colloid; Or taking animal skins or bone, first, angle as raw material, extract colloid, add adjuvant, be condensed into thick glue shape, do not make after drying liquid-type Chinese medicine colloid.Implementing formula sees table:
Generally: in every 100 kilograms of virgin rubbers, add litsea cubeba oil 0.1-2 kilogram and/or perilla oil 0.2-3 kilogram or/and 0.5 kilogram-4 kilograms of walnut oils, the total content of Fructus Litseae composition, Folium Perillae composition, Semen Juglandis composition (described composition generally refers to the oils of these materials) is controlled at 4 to 7 kilograms.This content data, except going for Colla Corii Asini, can also be applicable to other Chinese medicine colloid outside Colla Corii Asini.
Foregoing in " detailed description of the invention " goes for all embodiment described later, but while being otherwise noted in relevant consumption aftermentioned embodiment, preferentially selects the content of this explanation.
embodiment 1
While producing Colla Corii Asini, substitute 0.1% to 100% Oleum Glycines with litsea cubeba oil; Or substitute 0.2% to 100% Oleum Glycines with perilla oil; Or substitute 0.2% to 100% Oleum Glycines with walnut oil; Or do not reduce the use amount of original Oleum Glycines, add perilla oil 0.2% to 3% by virgin rubber amount; Or do not reduce the use amount of original Oleum Glycines, add litsea cubeba oil 0.1% to 2% by virgin rubber amount.Or
By litsea cubeba oil and perilla oil in 1 to 2 ratio proportioning after, the then Oleum Glycines of this Proportioning Oil replacing whole 0.1% to 100%; Or do not reduce the use amount of original Oleum Glycines, add this Proportioning Oil 0.1% to 3% by virgin rubber amount.
embodiment 2
Directly grey mountain seed, Fructus Perillae or its stem and leaf and stalk, Semen Juglandis are immersed in yellow wine, then add edible ethanol the ethanol content of dipping mixture is adjusted in to 20-30%, and airtight preservation is more than 10 days, then this mixed immersion fluid replacing whole yellow wine of leaching or part substitute yellow wine.The general grey seed in fresh mountain, Fructus Perillae or its stem and leaf and stalk, Semen Juglandis and the proportioning of yellow wine of adopting is 0.5 than 1(yellow wine), then ethanol content is adjusted to 20-30% airtight preservation with edible ethanol, dip time was advised more than 15 days.
In order to improve leaching effect, can will after grey fresh mountain seed, Folium Perillae plant and seed thereof, Semen Juglandis fragmentation, flood again.
The largest benefit of this method is: the little miniature glue enterprise that is suitable for lacking inspection facility, because little Wei enterprise generally cannot be furnished with inspection machine, the true and false of litsea cubeba oil, perilla oil and walnut oil of buying tested, use this method can self manufacture containing the adjuvant of Fructus Litseae, Folium Perillae, Semen Juglandis composition.
The adjuvant Substitute For Partial that can make by this method, also can extremely all yellow wine of Substitute For Partial to whole Oleum Glycines.
embodiment 3
Oleum Glycines in producing with the fat substituted Colla Corii Asini of Fructus Litseae (seed).The existing ripe technological borrowing of extractive technique of the grey seed fat in mountain.While using Fructus Litseae fat to substitute Oleum Glycines production Colla Corii Asini, can not use Alumen class adjuvant, to reduce the content of aluminum in Colla Corii Asini, helpful for the quality that improves Colla Corii Asini.Fructus Litseae (seed) fat-extraction technique can be with reference to " biomass Chemical Engineering " the 06th phase in 1992 " Fructus Litseae kernel oil extracts fatty acid process introduction " (author Bao Yipei) literary composition.
embodiment 4
By after Fructus Litseae fruit, Folium Perillae plant and seed thereof, Semen Juglandis pulping, to virgin rubber filter before add and stir after with raw material or together infusion of virgin rubber.This method has a maximum feature to be exactly: be applicable to little Wei enterprise and use; Also can effectively reduce the stink that raw material distributes in infusion process.
embodiment 5
Produced in kind at Colla Corii Asini, and with after the alternative bean amount 5-100% of walnut oil, separately pressed virgin rubber amount and add: 0.5-2% litsea cubeba oil; Or the perilla oil of 1-3%; Or the oily 0.8-3% that coordinates with the ratio of perilla oil 1 to 2 of litsea cubeba oil.
embodiment 6
In medicine colloid production process, especially, in the production process of Colla Corii Asini, substitute 0.1% to 100% Oleum Glycines with litsea cubeba oil; Or substitute 0.2% to 100% Oleum Glycines with perilla oil; Or substitute 0.2% to 100% Oleum Glycines with walnut oil; Or do not reduce the use amount of original Oleum Glycines, add perilla oil 0.2% to 3% by virgin rubber amount; Or do not reduce the use amount of original Oleum Glycines, add litsea cubeba oil 0.1% to 2% by virgin rubber amount.Or
By litsea cubeba oil and perilla oil in 1 to 2 ratio proportioning after, then this Proportioning Oil substitutes 0.1% to 100% Oleum Glycines; Or do not reduce the use amount of original Oleum Glycines, add this Proportioning Oil 0.1% to 3% by virgin rubber amount.
embodiment 7
Using finished product Colla Corii Asini, as with adding Fructus Litseae composition in block Colla Corii Asini deep-processing process or/and Folium Perillae composition or and Semen Juglandis composition, and mix with Colla Corii Asini.General recommendations is used the oils of these compositions.No matter be to use separately or mix to use these compositions, suggestion addition (calculating by final finished amount) litsea cubeba oil is controlled at 0.1-3%; Perilla oil is controlled between 0.5-3%; Walnut oil is controlled at 1-5%, if use Semen Juglandis powder, consumption can add arbitrarily according to the needs of Colla Corii Asini content; If make an addition in Colla Corii Asini finely processed product better effects if after Semen Juglandis is processed by micronizing.Be added with the Colla Corii Asini fabricated product of Semen Juglandis composition, be suitable for adding Fructus Litseae composition simultaneously, or Folium Perillae composition, or the mixture of Fructus Litseae composition and Folium Perillae composition, to extend the shelf-life (shelf life) of goods, especially can improve oxidation resistance and the anti-mildew degeneration energy of goods.
Above-mentioned adjuvant addition (calculating by final finished weight) is if total amount should be controlled general control in the time that 0.5-5%(uses Semen Juglandis powder, and Semen Juglandis powder amount is not subject to the limits).
This method is equally applicable to the deep processing of other colloid outside Colla Corii Asini.Deep processing raw material used can be both with the made colloid raw material of the present invention, can be also the colloid raw material of making by conventional method.If the raw material making with the present invention can suitably reduce Fructus Litseae composition or/and Folium Perillae composition or and Semen Juglandis composition consumption 20-60%.
embodiment 8
Taking animal skins or bone, first, angle as raw material, extract colloid, add adjuvant, be condensed into thick glue shape, the solid-state Chinese medicine colloid of making after drying; Or taking animal skins or bone, first, angle as raw material, extract colloid, add adjuvant, be condensed into thick glue shape, do not make after drying liquid-type Chinese medicine colloid.
The so-called interpolation adjuvant of the present embodiment is: substitute 0.1% to 100% Oleum Glycines with litsea cubeba oil; Or substitute 0.2% to 100% Oleum Glycines with perilla oil; Or substitute 0.2% to 100% Oleum Glycines with walnut oil; Or do not reduce the use amount of original Oleum Glycines, add perilla oil 0.2% to 2% by virgin rubber amount; Or do not reduce the use amount of original Oleum Glycines, add litsea cubeba oil 0.1% to 2% by virgin rubber amount, or
By litsea cubeba oil and perilla oil in 1 to 2 ratio proportioning after, then substitute 0.1% to 100% Oleum Glycines with this Proportioning Oil; Or do not reduce the use amount of original Oleum Glycines, add this Proportioning Oil 0.1% to 2% by virgin rubber amount, or
After Oleum Glycines with the completely alternative Oleum Glycines of walnut oil or alternative 5-100%, add in addition by virgin rubber amount: 0.5-2% litsea cubeba oil; Or the perilla oil of 1-3%; Or the oily 0.8-3% that coordinates with the ratio of perilla oil 1 to 2 of litsea cubeba oil.
embodiment 9
Semen Juglandis is carried out after micronizing, at virgin rubber, as added this Semen Juglandis powder that passes through micronizing in Colla Corii Asini concentration process, produce a kind of Chinese medicine colloid that contains Semen Juglandis powder.
The addition of Semen Juglandis powder is generally the 8-15% of virgin rubber weight; Can add litsea cubeba oil or/and perilla oil, the total addition level of this two classes material is recommended as the 1-3% of virgin rubber weight simultaneously.
Attention: because having added oleaginous material Semen Juglandis, can be less with or without Oleum Glycines.
embodiment 10
Copy technique for producing fruit wine, taking Fructus Litseae fruit or/and Fructus Perillae (can be also its stem and leaf) or/and Semen Juglandis as raw material, make Fructus Litseae fruit wine, perilla fruit wine, Semen Juglandis wine, when production, be suitable for Mel be carbon source, other technique is completely according to technique for producing fruit wine, after making fruit wine, can add edible ethanol and regulate alcohol content to 20-30%.With the method produce fruit wine can substitute wholly or in part yellow wine.
Also can use the carbon source of crystal sugar as fermentation, finished product fruit wine is measured after sugar part content, can suitably reduce the phase application quantity of crystal sugar in the production of Chinese medicine glue, in order to avoid affect the content value of the Main Ingredients and Appearance in Chinese medicine colloid finished product.
" fruit wine manufacture method " book that other concrete manufacture method of fruit wine can be published with reference to China's chemical industry publishing house in January, 2010.
embodiment 11
Taking Fructus Litseae fruit or/and Fructus Perillae (can be also its stem and leaf) or/and Semen Juglandis as raw material, to produce fat yeast (Chinese microorganism strain is recommended the existing strain that can suitability for industrialized production in center with guarantee and provided) or other mycete, algae as fermented bacterium, Mel or crystal sugar are added in fermenting carbon source suggestion, microbial grease production procedure is copied in technological process before fermentation completely, after having fermented, in order to reduce equipment investment, can directly adopt milling process squeezing extracting liq composition, in order to improve storage life, can add alcohol content to 20-30%, and mix; Also can adopt supercritical CO 2 extraction to prepare litsea cubeba oil, perilla oil, walnut oil.If to produce fat mycete as fermented bacterium, suggestion adopts supercritical CO 2 extraction to prepare litsea cubeba oil, perilla oil, walnut oil.The oils and fats that this method makes can substitute completely or part substitutes Oleum Glycines in Colla Corii Asini production technology or/and yellow wine.
Other method can list of references: " research of oils and fats is prepared in microorganism " literary composition that " regenerative resource " the 6th phase in 2006 (total the 130th phase) publishes.
Finished product fruit wine is measured after sugar part content, can suitably be reduced the phase application quantity of crystal sugar in the production of Chinese medicine glue, in order to avoid affect the content value of the Main Ingredients and Appearance in Chinese medicine colloid finished product.
supplemental instruction
1. in order to reduce the cost that uses litsea cubeba oil, perilla oil, can adopt the mixture of Distillation recovery mode recovery section litsea cubeba oil and Folium Perillae volatile matter, so that recycling.
2. because of the kind difference of Folium Perillae, quality for perilla oil or its ethanol extract has Different Effects, the perilla oil that suggestion is used this kind of Salvia Sclare L. (Latin name is called Salvia sclarea L or the long hat of its close kind Salvia japonica Thunb. S. plectranthoides Griff) to make.
3. the litsea cubeba oil of indication of the present invention had both comprised the litsea cubeba oil that adopts the way of distillation to produce, and also comprised the Fructus Litseae extract that the grey seed fat in the mountain of producing with milling process and other way make.
4. the perilla oil of indication of the present invention had both comprised the Folium Perillae volatile matter that adopts the way of distillation to produce, and also comprised the Folium perillae extract that Fructus Perillae is fatty and other way makes of producing with milling process.
5. can before glue process filter glue process, directly drop into Fructus Litseae, perilla stem and leaves and fruit thereof, walnut powder or Semen Juglandis powder etc. broken or that pulverize or their fabricated product (as litsea cubeba oil, perilla oil, walnut oil).A largest benefit that drops in advance these compositions can be the stink that lowers production environment.
6. the flow process of use litsea cubeba oil, perilla oil, walnut oil can be consistent with the flow process of use Oleum Glycines or yellow wine.
7. because the cost that uses perilla oil is more or less the same with the cost that uses Oleum Glycines, keypoint recommendation uses perilla oil to substitute Oleum Glycines and manufactures Colla Corii Asini.Use the Colla Corii Asini made of perilla oil in the raising of vitamin content and prevent in the mouldy performance of Colla Corii Asini, finding significance through experiment.Litsea cubeba oil and perilla oil are used in conjunction with more good synergism.
8. the technology of the present invention can be applied to liquid colloid equally, as ass glue oral liquid.
Of the present invention and Oleum Glycines, should expand and be interpreted as except Oleum Glycines, also comprise rice oil, Oleum Arachidis hypogaeae semen, Oleum Sesami, Oleum Brassicae campestris, Camellia oil, Semen Maydis oil, safflower oil, Oleum Gossypii semen, Oleum Helianthi quasi-grease, and for the convenience of the present invention in statement, in associated documents, only use " Oleum Glycines " word, but " Oleum Glycines " not only refers to Oleum Glycines, also refer to rice oil, Oleum Arachidis hypogaeae semen, Oleum Sesami, Oleum Brassicae campestris, Camellia oil, Semen Maydis oil, safflower oil, Oleum Gossypii semen, Oleum Helianthi quasi-grease.
10. the present invention can be extended to and become various peroral dosage forms with the deep processing of finished product Chinese medicine colloid, as become oral liquid, ball, loose, cream, pellet, wine, tea, ingot, concentrated pill, capsule, micropill, tablet, drop pill etc. with the deep processing of Colla Corii Asini piece, in these dosage form processes of production, add the composition of Fructus Litseae, Folium Perillae, Semen Juglandis etc., adding flow process generally can be with reference to the method for adding conventional adjuvant.
11., if the present invention do not indicate unit especially, generally refer to weight.
12. the present invention can expand or be transplanted to the manufacture field of food Colla Corii Asini, because Colla Corii Asini is medicine and food.
The strain using in the microbial fermentation technology of pointing out in 13. embodiment is if not through the kind of qualification, need to identify that the output object of this microorganism meets the requirement of food and pharmaceutical.
The data that relate in 14. the present invention, except there being the epigenesist that clearly has evaluating method announcement, the result that other control methods system draws after being analyzed with reference to the method for pointing out as Publication about Document:
15. other technology that do not describe are with reference to routine techniques.
(inventor's statement: this supplemental instruction is also considered as one of content in this description.）
Claims (10)
1. a Chinese medicine colloid, especially taking animal skins or bone, first, angle as raw material, extracts colloid, adds adjuvant, is condensed into thick glue shape, the solid-state Chinese medicine colloid of making after drying; Or taking animal skins or bone, first, angle as raw material, extract colloid, add adjuvant, be condensed into thick glue shape, the liquid Chinese medicine colloid of not making after drying; Or/and add the oral Chinese medicine colloid of making after adjuvant during with the deep processing of finished product Chinese medicine colloid, it is characterized in that containing in described " adjuvant "
fructus Litseae composition or/and Folium Perillae composition or/and Semen Juglandis composition; Or just refer to
2. Chinese medicine colloid as claimed in claim 1, is characterized in that in described Chinese medicine colloid containing having plenty of: litsea cubeba oil or/and perilla oil or/and walnut oil.
3. Chinese medicine colloid as claimed in claim 1, is characterized in that containing (virgin rubber weight) in described Chinese medicine colloid: litsea cubeba oil 0.1%-2% and/or perilla oil 0.2%-3% are or/and walnut oil 0.5%-4%; The total content of Fructus Litseae composition, Folium Perillae composition, Semen Juglandis composition is controlled at 4% to 7%.
4. Chinese medicine colloid as claimed in claim 1, this colloid is a kind of Colla Corii Asini, it is characterized in that containing in this Colla Corii Asini: litsea cubeba oil 0.1%-2% and/or perilla oil 0.2%-3% are or/and walnut oil 0.5%-4%, and the total content of Fructus Litseae composition, Folium Perillae composition, Semen Juglandis composition is controlled at 4% to 7%.
5. Chinese medicine colloid is manufactured an adjuvant, especially taking animal skins or bone, first, angle as raw material, extracts colloid, adds adjuvant, is condensed into thick glue shape, makes after drying the adjuvant adding in solid-state Chinese medicine colloid process; Or taking animal skins or bone, first, angle as raw material, extract colloid, add adjuvant, be condensed into thick glue shape, do not make after drying the adjuvant adding in liquid Chinese medicine colloid process; Or the adjuvant adding in finished product Chinese medicine colloid deep-processing process, it is characterized in that containing in described " adjuvant "
fructus Litseae composition or/and Folium Perillae composition or/and Semen Juglandis composition.
6. Chinese medicine colloid as claimed in claim 5 is manufactured adjuvant, it is characterized in that containing in every 100 kilograms of virgin rubbers this adjuvant: litsea cubeba oil 0.1-2 kilogram and/or perilla oil 0.2-3 kilogram are or/and walnut oil 0.5-4 kilogram; The total content of Fructus Litseae composition, Folium Perillae composition, Semen Juglandis composition is controlled at 4 to 7 kilograms.
7. Chinese medicine colloid as claimed in claim 5 is manufactured adjuvant, especially a kind of manufacture adjuvant of Chinese medicine colloid Colla Corii Asini, it is characterized in that containing in every 100 kilograms of virgin rubbers this adjuvant: litsea cubeba oil 0.1-2 kilogram and/or perilla oil 0.2-3 kilogram are or/and 0.5 kilogram-4 kilograms of walnut oils, and the total content of Fructus Litseae composition, Folium Perillae composition, Semen Juglandis composition is controlled at 4 to 7 kilograms.
8. a Chinese medicine colloid manufacture method, especially, taking animal skins or bone, first, angle as raw material, takes colloid, adds adjuvant, is condensed into thick glue shape, the solid-state Chinese medicine colloid manufacture method of making after drying; Or taking animal skins or bone, first, angle as raw material, take colloid, and add adjuvant, be condensed into thick glue shape, the liquid Chinese medicine colloid manufacture method that drying is not made; Or a kind of Chinese medicine colloid manufacture method of making add adjuvant in finished product Chinese medicine colloid deep processing manufacture process after, it is characterized in that described " interpolation adjuvant ":
the production process of Chinese medicine colloid use Fructus Litseae composition or/and Folium Perillae composition as adjuvant, part substitutes or replacing whole Chinese medicine colloid manufacture in the conventional adjuvant Oleum Glycines using; Or
9. Chinese medicine colloid manufacture method as claimed in claim 8, the adjuvant of using in especially a kind of manufacture method of Chinese medicine colloid Colla Corii Asini, is characterized in that:
Substitute 0.1% to 100% Oleum Glycines with litsea cubeba oil; Or substitute 0.2% to 100% Oleum Glycines with perilla oil; Or substitute 0.2% to 100% Oleum Glycines with walnut oil; Or do not reduce the use amount of original Oleum Glycines, add perilla oil 0.2% to 3% by virgin rubber amount; Or do not reduce the use amount of original Oleum Glycines, add litsea cubeba oil 0.1% to 2% by virgin rubber amount, or:
By litsea cubeba oil and perilla oil in 1 to 2 ratio proportioning after, then substitute 0.1% to 100% Oleum Glycines with this Proportioning Oil; Or do not reduce the use amount of original Oleum Glycines, add this Proportioning Oil 0.1% to 2% by virgin rubber amount, or:
After Oleum Glycines with the completely alternative Oleum Glycines of walnut oil or alternative 5-100%, add in addition by virgin rubber amount: 0.5-2% litsea cubeba oil; Or the perilla oil of 1-3%; Or the oily 0.8-3% that coordinates with the ratio of perilla oil 1 to 2 of litsea cubeba oil; Or:
In to virgin rubber concentration process, add the Semen Juglandis powder that has passed through micronizing, the addition of Semen Juglandis powder is the 8-15% of virgin rubber weight; Can add litsea cubeba oil or/and perilla oil, the total addition level of this two classes material is the 1-3% of virgin rubber weight simultaneously.
10. a Chinese medicine colloid as claimed in claim 1, contains Fructus Litseae, Folium Perillae, Semen Juglandis composition in this Chinese medicine glue, it is characterized in that described Fructus Litseae, Folium Perillae, Semen Juglandis composition refer to Fructus Litseae fruit wine, perilla fruit wine, Semen Juglandis fruit wine; Or Fructus Litseae, Folium Perillae, Semen Juglandis are squeezed to the liquid after its fermentation of leaching after the technical finesse of microorganism fermentation oils and fats.
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| CN108715791A (en) * | 2018-05-29 | 2018-10-30 | 李伟达 | A kind of production method of apple vinegar beverage |
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| CN101439048A (en) * | 2007-11-22 | 2009-05-27 | 何煜 | Chinese medicine glue rapid-release preparation for oral cavity and method for producing the same |
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