CN103868998B - A kind of chromatography treatment and chromatograph - Google Patents
A kind of chromatography treatment and chromatograph Download PDFInfo
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- CN103868998B CN103868998B CN201210535718.1A CN201210535718A CN103868998B CN 103868998 B CN103868998 B CN 103868998B CN 201210535718 A CN201210535718 A CN 201210535718A CN 103868998 B CN103868998 B CN 103868998B
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Abstract
The present embodiments relate to chromatography field, more particularly to a kind of chromatography treatment and chromatograph.The chromatography treatment includes：Obtain the deletion region that user specifies；Judge the vertex deleted and whether include peak in region；If it has, then deleting the peak.The chromatograph includes：Receiving unit, judging unit and execution unit；The receiving unit is for obtaining the deletion region that user specifies；The judging unit is used to judge whether to include in the deletion region vertex at peak；If so, deleting the peak by the execution unit.A kind of chromatography treatment provided in an embodiment of the present invention and chromatograph, as long as meeting the vertex at peak in the deletion region that user specifies, this method can directly delete the peak comprising the vertex, and one side user's operation is simple, on the other hand reduce the complexity that technology is realized.
Description
Technical field
The present invention relates to chromatography field, more particularly to a kind of chromatography treatment and chromatograph.
Background technology
The chromatograph of industry is provided with chromatographic work station at present, on the one hand chromatographic work station completes the control to slave computer
On the other hand system carries out analyzing processing to collected chromatographic data.
During laboratory technician carries out chemical analysis, influence of the solvent peak to its adjacent peak, generally requires in order to prevent
Delete solvent peak；In addition there is also such situations：For example when doing drugs analysis, certain in concern sample to be tested is sometimes needed
Several substances, and other substances are not relevant for, this just needs the peak for deleting remaining impurity.
Existing chromatographic work station when carrying out deletion peak, can comparison peak the region specified of beginning and end and user
（Point）With the presence or absence of inclusion relation, if the beginning and end at peak is in the region that user specifies（Point）It is interior, then can delete
The peak, on the contrary peak cannot be deleted.
At least there are following defects in the method at above-mentioned deletion peak：Since it is desired that ensureing the beginning and end at peak in user
Specified region（Point）It is interior, when needing the distance between the peak deleted and other peaks to be sufficiently close in obtained chromatographic data
When, certain trouble, user can be brought not only to need to consider that the region will include deleted peak to the operation of user designated area
Origin And Destination, it is also necessary to prevent from accidentally deleting other peaks, thus this method on the one hand technology realization on complexity can compare
Higher, another aspect user's operation is also inconvenient.
Invention content
The embodiment of the present invention provides a kind of chromatography treatment, must satisfy peak in existing deletion peak technology for solving
The region that beginning and end is specified with user（Point）There are inclusion relation, cause to be easy accidentally to delete peak in operation；And technology is real
The problems such as complexity on now can be relatively high, and user's operation is also inconvenient.
The embodiment of the present invention provides a kind of chromatography treatment, wherein the method includes：
Obtain the deletion region that user specifies；
Judge the vertex deleted and whether include peak in region；If it has, then deleting the peak.
Above-mentioned chromatography treatment, wherein the deletion region that the acquisition user specifies includes：Obtain the deletion region
The abscissa of Origin And Destination.
Above-mentioned chromatography treatment, wherein judge whether the vertex comprising peak includes in the deletion region：Described in judgement
Whether the abscissa on the vertex at peak is more than the abscissa for deleting region starting point, and whether is less than the deletion region terminal
Abscissa.
Above-mentioned chromatography treatment, wherein judge whether the vertex comprising peak includes in the deletion region：Described in judgement
Whether the maximum at peak described in deletion region is equal to the ordinate on the vertex at the peak.
Above-mentioned chromatography treatment, wherein the method further includes：Detection baseline, which whether there is, to be run through；If so, adjustment
The starting point or terminal at peak.
The embodiment of the present invention also provides a kind of chromatograph, wherein the chromatograph includes：
Receiving unit, judging unit and execution unit；
The receiving unit is for obtaining the deletion region that user specifies；
The judging unit is used to judge whether to include in the deletion region vertex at peak；If so, by the execution
Peak described in element deletion.
Above-mentioned a kind of chromatograph, wherein the receiving unit is specifically used for obtaining deletion region Origin And Destination
Abscissa.
Above-mentioned a kind of chromatograph, wherein the judging unit is specifically used for judging that the abscissa on the vertex at the peak is
The no abscissa more than the deletion region starting point, and whether it is less than the abscissa for deleting region terminal.
Above-mentioned a kind of chromatograph, wherein the judging unit is specifically used for judging peak described in the deletion region
Whether maximum is equal to the ordinate on the vertex at the peak.
Above-mentioned a kind of chromatograph, wherein further including：
Detection unit and adjustment unit；
The detection unit is for detecting baseline with the presence or absence of running through；If so, adjusting peak by the adjustment unit
Point or terminal.
In conclusion a kind of chromatography treatment provided in an embodiment of the present invention and chromatograph, as long as meeting the vertex at peak
In the deletion region that user specifies, this method can directly delete the peak comprising the vertex, and one side user's operation is simple, another
Aspect reduces the complexity that technology is realized.
Description of the drawings
Attached drawing described herein is used to provide further understanding of the present invention, and is constituted part of this application, not
Constitute limitation of the invention.In the accompanying drawings：
Fig. 1 is a kind of flow chart of chromatography treatment in the embodiment of the present invention；
Fig. 2 is a kind of chromatographic structural schematic diagram in the embodiment of the present invention；
Fig. 3 A to Fig. 3 E are the chromatography schematic diagram with chromatography treatment in the prior art；
Fig. 4 A to Fig. 4 C are the chromatography schematic diagram with a kind of chromatography treatment in the embodiment of the present invention.
Specific implementation mode
To make the objectives, technical solutions, and advantages of the present invention clearer, the present invention is implemented below in conjunction with the accompanying drawings
Example is described in further detail.Here, the illustrative embodiments of the present invention and their descriptions are used to explain the present invention, but it is not intended as
Limitation of the invention.
The embodiment of the present invention provides a kind of chromatography treatment, as shown in Figure 1, wherein this method includes：
Step 101, the deletion region that user specifies is obtained；Preferably, obtaining the cross for deleting region Origin And Destination
Coordinate.
Step 102, judge the vertex deleted and whether include peak in region；User specified one deletes region, preferably
The starting point and/or terminal for not including peak in the deletion region, need to only include the vertex at peak.
If it has, then entering step 103；If it is otherwise, it returns to step 101, reassigns and deletes region.
Step 103, the peak is deleted.If it includes more than two peaks to delete in region, each peak can be according to above-mentioned
Method is judged.Wherein, method can be used in this field after obtaining judging result, used by the deletion peak commonly uses at present
Method, therefore repeated no more in the present embodiment.Cycle deletes all solvent peaks and impurity peaks successively, by remaining remaining peak
Carry out the analyzing processing of next step.
A kind of chromatography treatment provided through the embodiment of the present invention, as long as the vertex for meeting peak is deleted what user specified
Except region, this method can directly delete the peak comprising the vertex, and one side user's operation is simple, and it is real on the other hand to reduce technology
Existing complexity.
A kind of chromatography treatment provided in an embodiment of the present invention in one preferable embodiment, judges the deletion area
Whether the vertex comprising peak includes in domain：Judge whether the abscissa on the vertex at the peak is more than the cross for deleting region starting point
Coordinate, and whether it is less than the abscissa for deleting region terminal.Specifically, when chromatographic work station obtains a chromatogram,
The dependent coordinate information on the recorded vertex for having all peaks, such as：Abscissa X and ordinate Y.At this point, by the abscissa at peak
The abscissa A of starting point and the abscissa B of terminal in the deletion region specified respectively with user are compared, i.e., by X respectively with
A, B is compared, when obtained comparison result is：When A≤X≤B, the vertex deleted and include the peak in region is indicated,
The peak comprising the vertex can then be deleted, otherwise not deleted, if it includes more than two peaks to delete in region, each peak is equal
It can be judged according to above-mentioned method.When in specified deletion region do not include any peak that can be deleted, then need to by with
Family, which is reassigned, deletes the above identical operation of region progress.
A kind of chromatography treatment provided in an embodiment of the present invention in another preferable embodiment, judges the deletion
Whether the vertex comprising peak includes in region：Judge whether the maximum at peak described in the deletion region is equal to the top at the peak
The ordinate of point.Specifically, assuming that the ordinate on the vertex at the peak is Y, the deletion region that user specifies is M, is found in M
The maximum Z at the peak indicates that the maximum is the maximum value at the peak, i.e. ordinate Y can then be carried out in next step as Z=Y
Delete the operation at peak.If it includes more than two peaks to delete in region, each peak can also be judged according to above-mentioned method.
A kind of chromatography treatment provided in an embodiment of the present invention, in a preferable embodiment, the method further includes：
Detection baseline, which whether there is, to be run through；If so, the starting point or terminal at adjustment peak.Here, baseline is through referring to：Baseline and chromatography
There is the intersection point in addition to the starting point at peak and terminal in data.When baseline occur and running through, the starting point or the end that adjust peak are needed
Point is for the purpose of reaching and not generate and run through.
The embodiment of the present invention also provides a kind of chromatograph, wherein as shown in Fig. 2, the chromatograph includes：
Receiving unit 201, judging unit 202 and execution unit 203；
The receiving unit 201 is for obtaining the deletion region that user specifies；Preferably, the receiving unit 201 is specific
For obtaining the abscissa for deleting region Origin And Destination.
The judging unit 202 is used to judge whether to include in the deletion region vertex at peak；If so, being held by described
Row unit 203 deletes the peak.User specified one deletes region, do not include in the preferable deletion region peak starting point and/or
Terminal need to only include the vertex at peak.If it includes more than two peaks to delete in region, each peak can be according to above-mentioned side
Method is judged.Wherein, after judging unit 202 obtains judging result, the side at peak is deleted used by above-mentioned execution unit 203
Currently used method in this field can be used in method, therefore is repeated no more in the present embodiment.Cycle deletes all solvent peaks successively
And impurity peaks, remaining remaining peak, you can carry out the analyzing processing of next step.
A kind of chromatography treatment provided through the embodiment of the present invention, as long as the vertex for meeting peak is deleted what user specified
Except region, this method can directly delete the peak comprising the vertex, and one side user's operation is simple, and it is real on the other hand to reduce technology
Existing complexity.
A kind of chromatograph provided in an embodiment of the present invention, in a preferable embodiment, the judging unit is specifically used for
Judge whether the abscissa on the vertex at the peak is more than the abscissa for deleting region starting point, and whether is less than the deletion area
The abscissa of domain terminal.Specifically, when chromatographic work station obtains a chromatogram, the correlation on the vertex at all peaks is had been recorded with
Coordinate information, such as：Abscissa X and ordinate Y.At this point, comparing unit uses the abscissa at peak with receiving unit respectively
The abscissa A of starting point and the abscissa B of terminal in the specified deletion region in family are compared, i.e., compare X with A, B respectively
Compared with when obtained comparison result is：When A≤X≤B, indicates the vertex deleted and include the peak in region, then notify to execute
Unit deletes the peak comprising the vertex, does not otherwise delete, if it includes more than two peaks to delete in region, each peak is equal
It can be judged according to above-mentioned method.It, then need to be by sentencing when not including any peak that can be deleted in specified deletion region
Disconnected unit sends out alarm, and prompts user to reassign and delete the above identical operation of region progress.
A kind of chromatograph provided in an embodiment of the present invention, in another preferable embodiment, the judging unit is specifically used
In judge it is described deletion region described in peak maximum whether be equal to the peak vertex ordinate.Specifically, assuming institute
The ordinate for stating the vertex at peak is Y, and the deletion region that the user of receiving unit record specifies is M, and the judging unit is looked in M
To the peak maximum Z and Z is compared with Y, as Z=Y, indicate that the maximum is the maximum value at the peak, i.e. ordinate
Y can then notify the execution unit delete in next step the operation at peak.If it includes more than two peaks to delete in region,
Each peak can also be judged according to above-mentioned method.
A kind of chromatograph provided in an embodiment of the present invention, in a preferable embodiment, the chromatograph further includes：
Detection unit and adjustment unit；
The detection unit is for detecting baseline with the presence or absence of running through；If so, adjusting peak by the adjustment unit
Point or terminal.Here, baseline is through referring to：There is the intersection point in addition to the starting point at peak and terminal with chromatographic data in baseline.
When detection unit detects that baseline occur runs through, the starting point at adjustment unit adjustment peak or terminal is needed to be passed through to reach not generate
For the purpose of wearing.
In order to preferably describe embodiments of the present invention and make comparisons with the prior art, said below with example
It is bright.
Fig. 3 A to Fig. 3 E are with the chromatography schematic diagram of chromatography treatment in the prior art, and Fig. 4 A to Fig. 4 C are with this
A kind of chromatography schematic diagram of chromatography treatment in inventive embodiments, processing is similarly sized in different chromatograms（It is i.e. high
Degree is essentially identical with width）Peak, i.e. 3A and 4A, specifically：
When needing to delete the 8th peak in Fig. 3 A, as shown in Figure 3B, is selected using the method for the prior art and delete region
M, subsequent chromatographic work station proceed by deletion step, obtain Fig. 3 C, not from the 8th peak that can be seen that in Fig. 3 C in the chromatography
Have it is deleted, the reason is that because the selected region of deleting of user does not completely include the starting point and terminal at the peak.In addition,
It is selected again using the method for the prior art and deletes region N, as shown in Figure 3D, it can be seen from the figure that deletion region N is larger,
Deletion step then is carried out, obtains Fig. 3 E, the peak is deleted in Fig. 3 E.It follows that needing to ensure rising for peak in the prior art
Point and terminal are in the region that user specifies（Point）Interior, general user can not accurately grasp the size in the deletion region, therefore
It needs a very wide in range region is specified just to can guarantee that peak is deleted, but works as and need to delete in obtained chromatographic data
When the distance between peak and other peaks are sufficiently close to, if specifying a wide in range deletion region, it is easy to by other useful peaks
It is accidentally deleted, therefore great difficulty is caused to the operation of user.
The chromatography treatment provided again with the embodiment of the present invention now handles peak as shown in Figure 4 A.Specifically
's：
When needing to delete the 7th peak in Fig. 4 A, as shown in Figure 4 B, the deletion region P that user specifies is obtained, hence it is evident that can
To find out, the starting point and terminal deleted region P and do not include the peak.Deletion step then is carried out, obtains Fig. 4 C, in Fig. 4 C
The peak is deleted.It follows that the chromatography treatment provided using the embodiment of the present invention, if meet the vertex at peak with
The specified deletion region in family, this method can directly delete the peak comprising the vertex, and one side user's operation is simple, on the other hand
The complexity that reduction technology is realized.
Above-described specific implementation mode has carried out further the purpose of the present invention, technical solution and advantageous effect
It is described in detail, it should be understood that the foregoing is merely the specific implementation mode of the present invention, is not intended to limit the present invention
Protection domain, all within the spirits and principles of the present invention, any modification, equivalent substitution, improvement and etc. done should all include
Within protection scope of the present invention.
Claims (2)
1. a kind of chromatography treatment, which is characterized in that the method includes：
Obtain the abscissa of the Origin And Destination in the deletion region that user specifies；
Judge the vertex deleted and whether include peak in region, wherein judge whether include the top at peak in the deletion region
Point specifically includes：Judge whether the abscissa on the vertex at the peak is more than the abscissa for deleting region starting point, and whether small
In the abscissa for deleting region terminal；If it has, then deleting the peak；
Detection baseline, which whether there is, to be run through；If so, the starting point or terminal at adjustment peak；
Wherein baseline runs through for baseline with chromatographic data in the presence of the intersection point in addition to the starting point at peak and terminal;
Judge whether the vertex comprising peak further includes in the deletion region：Judge the maximum at peak described in the deletion region
Whether the ordinate on the vertex at the peak is equal to.
2. a kind of chromatograph, which is characterized in that the chromatograph includes：
Receiving unit, judging unit and execution unit；
The receiving unit is used to obtain the abscissa of the Origin And Destination in the deletion region that user specifies；
The judging unit is used to judge whether to include in the deletion region vertex at peak, wherein the judging unit is specific
For judging whether the abscissa on the vertex at the peak is more than the abscissa for deleting region starting point, and whether it is less than described delete
Except the abscissa of region terminal；If so, deleting the peak by the execution unit；
Detection unit and adjustment unit；
The detection unit is for detecting baseline with the presence or absence of running through；If so, by the adjustment unit adjust peak starting point or
Person's terminal；Wherein baseline runs through for baseline with chromatographic data in the presence of the intersection point in addition to the starting point at peak and terminal;
The judging unit is specifically additionally operable to judge the top whether maximum at peak described in the deletion region is equal to the peak
The ordinate of point.
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| CN201210535718.1A CN103868998B (en) | 2012-12-12 | 2012-12-12 | A kind of chromatography treatment and chromatograph |
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| CN201210535718.1A CN103868998B (en) | 2012-12-12 | 2012-12-12 | A kind of chromatography treatment and chromatograph |
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| CN103868998B true CN103868998B (en) | 2018-11-02 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6112161A (en) * | 1997-09-17 | 2000-08-29 | Hewlett-Packard | Method, apparatus, and article of manufacture for enhanced intergration of signals |
| CN101002460A (en) * | 2004-06-23 | 2007-07-18 | 兰达解决方案公司 | Automatic background removal for input data |
| CN101384898A (en) * | 2006-06-08 | 2009-03-11 | 株式会社岛津制作所 | Data processing device for chromatograph mass spectrum analysis |
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2012
- 2012-12-12 CN CN201210535718.1A patent/CN103868998B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6112161A (en) * | 1997-09-17 | 2000-08-29 | Hewlett-Packard | Method, apparatus, and article of manufacture for enhanced intergration of signals |
| CN101002460A (en) * | 2004-06-23 | 2007-07-18 | 兰达解决方案公司 | Automatic background removal for input data |
| CN101384898A (en) * | 2006-06-08 | 2009-03-11 | 株式会社岛津制作所 | Data processing device for chromatograph mass spectrum analysis |
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