CN103868998A - Chromatogram processing method and chromatographic instrument - Google Patents
Chromatogram processing method and chromatographic instrument Download PDFInfo
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- CN103868998A CN103868998A CN201210535718.1A CN201210535718A CN103868998A CN 103868998 A CN103868998 A CN 103868998A CN 201210535718 A CN201210535718 A CN 201210535718A CN 103868998 A CN103868998 A CN 103868998A
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Abstract
The embodiment of the invention relates to the field of chromatographic analysis, and especially relates to a chromatogram processing method and a chromatographic instrument. The chromatogram processing method comprises: obtaining a deleting area appointed by a user; determining whether the deleting area comprises the top point of a peak; and deleting the peak if the deleting area comprises the top point. The chromatographic instrument comprises a receiving unit, a determining unit and an execution unit, the receiving unit is used to obtain the deleting area appointed by a user, the determining unit is used to determine whether the deleting area comprises the top point of a peak, and the execution unit is used to delete the peak if the deleting area comprises the top point. According to the chromatogram processing method and the chromatographic instrument provided by the embodiment of the invention, once the condition is satisfied that the top point of a peak is in the deleting area appointed by a user, according to the method, the peak containing the top point can be directly deleted, so that the operation of the user is simple on the one hand, and the realization complexity of technology is reduced on the other hand.
Description
Technical field
The present invention relates to stratographic analysis field, particularly a kind of chromatography treatment and chromatograph.
Background technology
The chromatograph of industry all provides chromatographic work station at present, and chromatographic work station completes the control to slave computer on the one hand, on the other hand the chromatographic data collecting is carried out to analyzing and processing.
Carry out in chemico-analytic process laboratory technician, in order to prevent the impact of solvent peak on its adjacent peak, generally need to delete solvent peak; Also there is in addition such situation: for example, in the time doing medicine and analyze, sometimes need to pay close attention to certain several material in testing sample, and and be indifferent to other materials, this just need to delete the peak of all the other impurity.
Existing chromatographic work station is in the time deleting peak, whether the region (point) that the starting point of meeting comparison peak and terminal and user specify there is relation of inclusion, if in the region (point) that the starting point at peak and terminal are all specified user, can delete so this peak, otherwise can not delete peak.
In the method at above-mentioned deletion peak, at least there is following defect: because need to guarantee in region (point) that the starting point at peak and terminal all specify user, when the peak that needs in obtained chromatographic data to delete and other peak-to-peak distances are while extremely approaching, can bring certain trouble to the operation of user designated area, user not only needs to consider that this region will comprise the Origin And Destination at deleted peak, also need to prevent from deleting other peaks by mistake, therefore the complexity on technology realizes can be higher on the one hand for the method, and user's operation is also inconvenient on the other hand.
Summary of the invention
The embodiment of the present invention provides a kind of chromatography treatment, and for solving, existing deletion peak technology must meet the starting point at peak and the region (point) of terminal and user's appointment exists relation of inclusion, causes easily deleting peak in operation by mistake; And the complexity that technology realizes can be higher, user operation is the problem such as inconvenient also.
The embodiment of the present invention provides a kind of chromatography treatment, and wherein, described method comprises:
Obtain the deletion region that user specifies;
Judge the summit that whether comprises peak in described deletion region; If yes, delete described peak.
Above-mentioned chromatography treatment, wherein, the deletion region that described acquisition user specifies comprises: the horizontal ordinate that obtains described deletion region Origin And Destination.
Above-mentioned chromatography treatment, wherein, judges that the summit that whether comprises peak in described deletion region comprises: judge whether the horizontal ordinate on the summit at described peak is greater than the horizontal ordinate of described deletion region starting point, and whether be less than the horizontal ordinate of described deletion region terminal.
Above-mentioned chromatography treatment, wherein, judges that the summit that whether comprises peak in described deletion region comprises: judge whether the maximum value at peak described in described deletion region equals the ordinate on the summit at described peak.
Above-mentioned chromatography treatment, wherein, described method also comprises: whether detection baseline exists and run through; If so, adjust starting point or the terminal at peak.
The embodiment of the present invention also provides a kind of chromatograph, and wherein, described chromatograph comprises:
Receiving element, judging unit and performance element;
The deletion region that described receiving element is specified for obtaining user;
Described judging unit is for judging whether described deletion region comprises the summit at peak; If so, delete described peak by described performance element.
Above-mentioned a kind of chromatograph, wherein, described receiving element is specifically for obtaining the horizontal ordinate of described deletion region Origin And Destination.
Above-mentioned a kind of chromatograph, wherein, whether described judging unit is greater than the horizontal ordinate of described deletion region starting point specifically for the horizontal ordinate on the summit that judges described peak, and whether is less than the horizontal ordinate of described deletion region terminal.
Above-mentioned a kind of chromatograph, wherein, described judging unit is specifically for judging whether the maximum value at peak described in described deletion region equals the ordinate on the summit at described peak.
Above-mentioned a kind of chromatograph, wherein also comprises:
Detecting unit and adjustment unit;
Whether described detecting unit exists and runs through for detection of baseline; If so, adjusted starting point or the terminal at peak by described adjustment unit.
In sum, a kind of chromatography treatment and chromatograph that the embodiment of the present invention provides, as long as meet the deletion region that specify user on the summit at peak, the method just can directly be deleted the peak that comprises this summit, user is simple to operate on the one hand, the complexity that reduction technology on the other hand realizes.
Accompanying drawing explanation
Accompanying drawing described herein is used to provide a further understanding of the present invention, forms the application's a part, does not form limitation of the invention.In the accompanying drawings:
Fig. 1 is the process flow diagram of a kind of chromatography treatment in the embodiment of the present invention;
Fig. 2 is a kind of chromatographic structural representation in the embodiment of the present invention;
Fig. 3 A to Fig. 3 E is the chromatogram schematic diagram that uses chromatography treatment in prior art;
Fig. 4 A to Fig. 4 C is the chromatogram schematic diagram that uses a kind of chromatography treatment in the embodiment of the present invention.
Embodiment
For making the object, technical solutions and advantages of the present invention clearer, below in conjunction with accompanying drawing, the embodiment of the present invention is described in further detail.At this, schematic description and description of the present invention is used for explaining the present invention, but not as a limitation of the invention.
The embodiment of the present invention provides a kind of chromatography treatment, and as shown in Figure 1, wherein, the method comprises:
If yes, enter step 103; If otherwise return to step 101, reassign and delete region.
A kind of chromatography treatment providing by the embodiment of the present invention, as long as meet the deletion region that specify user on the summit at peak, the method just can directly be deleted the peak that comprises this summit, user is simple to operate on the one hand, the complexity that reduction technology on the other hand realizes.
A kind of chromatography treatment that the embodiment of the present invention provides, one preferably in embodiment, judge that the summit that whether comprises peak in described deletion region comprises: judge whether the horizontal ordinate on the summit at described peak is greater than the horizontal ordinate of described deletion region starting point, and whether be less than the horizontal ordinate of described deletion region terminal.Concrete, in the time that chromatographic work station obtains a chromatogram, record the relevant coordinate information on the summit at all peaks, for example: horizontal ordinate X and ordinate Y.Now, the horizontal ordinate at peak is compared with the horizontal ordinate A of starting point and the horizontal ordinate B of terminal in deletion region that user specifies respectively, compare with A, B respectively by X, when the comparative result obtaining is: when A≤X≤B, represent the summit that comprises described peak in described deletion region, can delete the peak that comprises this summit, otherwise not delete, if comprise plural peak in deletion region, each peak all can judge according to above-mentioned method.When not comprising any peak that can delete in specified deletion region, need reassign deletion region by user and carry out above identical operation.
A kind of chromatography treatment that the embodiment of the present invention provides, another preferably in embodiment, judges that the summit that whether comprises peak in described deletion region comprises: judge whether the maximum value at peak described in described deletion region equals the ordinate on the summit at described peak.Concrete, the ordinate of supposing the summit at described peak is Y, and the deletion region that user specifies is M, finds the maximum value Z at described peak in M, in the time of Z=Y, represents that this maximum value is the maximal value at this peak, i.e. and ordinate Y can carry out the operation at next step deletion peak.If comprise plural peak in deletion region, each peak also can judge according to above-mentioned method.
A kind of chromatography treatment that the embodiment of the present invention provides, one preferably in embodiment, and whether described method also comprises: detect baseline and exist and run through; If so, adjust starting point or the terminal at peak.At this, baseline runs through and refers to: baseline and chromatographic data exist the intersection point except starting point and the terminal at peak.In the time occurring that baseline runs through, starting point or the terminal that need to adjust peak run through as object to reach not produce.
The embodiment of the present invention also provides a kind of chromatograph, and wherein, as shown in Figure 2, described chromatograph comprises:
Receiving element 201, judging unit 202 and performance element 203;
The deletion region that described receiving element 201 is specified for obtaining user; Preferably, described receiving element 201 is specifically for obtaining the horizontal ordinate of described deletion region Origin And Destination.
Described judging unit 202 is for judging whether described deletion region comprises the summit at peak; If so, delete described peak by described performance element 203.User specifies a deletion region, preferably in this deletion region, does not comprise starting point and/or the terminal at peak, only need comprise the summit at peak.If comprise plural peak in deletion region, each peak all can judge according to above-mentioned method.Wherein, when judging unit 202 obtains after judged result, the method at the deletion peak that above-mentioned performance element 203 adopts can adopt current conventional method in this area, therefore in the present embodiment, repeats no more.All solvent peaks and impurity peaks are deleted in circulation successively, and remaining last peak can carry out next step analyzing and processing.
A kind of chromatography treatment providing by the embodiment of the present invention, as long as meet the deletion region that specify user on the summit at peak, the method just can directly be deleted the peak that comprises this summit, user is simple to operate on the one hand, the complexity that reduction technology on the other hand realizes.
A kind of chromatograph that the embodiment of the present invention provides, one preferably in embodiment, whether described judging unit is greater than the horizontal ordinate of described deletion region starting point specifically for the horizontal ordinate on the summit that judges described peak, and whether is less than the horizontal ordinate of described deletion region terminal.Concrete, in the time that chromatographic work station obtains a chromatogram, record the relevant coordinate information on the summit at all peaks, for example: horizontal ordinate X and ordinate Y.Now, comparing unit by the horizontal ordinate at peak respectively with receiving element in the horizontal ordinate A of starting point and the horizontal ordinate B of terminal in deletion region that specify of user compare, compare with A, B respectively by X, when the comparative result obtaining is: when A≤X≤B, represent the summit that comprises described peak in described deletion region, notify performance element to delete the peak that comprises this summit, otherwise do not delete, if comprise plural peak in deletion region, each peak all can judge according to above-mentioned method.When not comprising any peak that can delete in specified deletion region, need send alarm by judging unit, and point out user to reassign deletion region and carry out above identical operation.
A kind of chromatograph that the embodiment of the present invention provides, another is preferably in embodiment, and described judging unit is specifically for judging whether the maximum value at peak described in described deletion region equals the ordinate on the summit at described peak.Concrete, the ordinate of supposing the summit at described peak is Y, the deletion region that the user of receiving element record specifies is M, described judging unit finds the maximum value Z at described peak and Z and Y is compared in M, in the time of Z=Y, represent that this maximum value is the maximal value at this peak, i.e. ordinate Y, can notify described performance element to carry out the operation at next step deletion peak.If comprise plural peak in deletion region, each peak also can judge according to above-mentioned method.
A kind of chromatograph that the embodiment of the present invention provides, one preferably in embodiment, and described chromatograph also comprises:
Detecting unit and adjustment unit;
Whether described detecting unit exists and runs through for detection of baseline; If so, adjusted starting point or the terminal at peak by described adjustment unit.At this, baseline runs through and refers to: baseline and chromatographic data exist the intersection point except starting point and the terminal at peak.When detecting unit detects while occurring that baseline runs through, the starting point or the terminal that need adjustment unit to adjust peak run through as object to reach not produce.
In order to describe better embodiments of the present invention and to make comparisons with prior art, describe with example below.
Fig. 3 A to Fig. 3 E is the chromatogram schematic diagram that uses chromatography treatment in prior art, Fig. 4 A to Fig. 4 C is the chromatogram schematic diagram that uses a kind of chromatography treatment in the embodiment of the present invention, the peak for similar size (being that height and the width are basic identical) in different chromatograms of its processing, be 3A and 4A, concrete:
When need to delete in Fig. 3 A the 8th peak time, as shown in Figure 3 B, utilize the selected region M of deletion of method of prior art, chromatographic work station starts to carry out delete step subsequently, obtain Fig. 3 C, from Fig. 3 C, can find out that the 8th peak in this chromatogram is not deleted, reason is because user-selected deletion region does not comprise starting point and the terminal at this peak completely.In addition, utilize the method selected region N of deletion again of prior art, as shown in Figure 3 D, as can be seen from the figure, N is larger in this deletion region, carries out subsequently delete step, obtains Fig. 3 E, and in Fig. 3 E, this peak is deleted.Hence one can see that, in prior art, need to guarantee in the starting point at peak and region (point) that terminal is all specified user, general user cannot grasp the size in this deletion region accurately, therefore need to specify a very wide in range guarantee peak, region deleted, but work as while needing the peak of deletion and other peak-to-peak distances extremely to approach in obtained chromatographic data, if specify a wide in range deletion region, be easy to other useful peaks to delete by mistake, cause great difficulty therefore to user's operation.
Now with the chromatography treatment that the embodiment of the present invention was provided, peak is as shown in Figure 4 A processed again.Concrete:
When need to delete in Fig. 4 A the 7th peak time, as shown in Figure 4 B, obtain user specify deletion region P, obviously can find out, described deletion region P does not comprise starting point and the terminal at this peak.Carry out subsequently delete step, obtain Fig. 4 C, in Fig. 4 C, this peak is deleted.Hence one can see that, the chromatography treatment that adopts the embodiment of the present invention to provide, as long as meet the deletion region that specify user on the summit at peak, the method just can directly be deleted the peak that comprises this summit, user is simple to operate on the one hand, the complexity that reduction technology on the other hand realizes.
Above-described embodiment; object of the present invention, technical scheme and beneficial effect are further described; institute is understood that; the foregoing is only the specific embodiment of the present invention; the protection domain being not intended to limit the present invention; within the spirit and principles in the present invention all, any modification of making, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (10)
1. a chromatography treatment, is characterized in that, described method comprises:
Obtain the deletion region that user specifies;
Judge the summit that whether comprises peak in described deletion region; If yes, delete described peak.
2. chromatography treatment according to claim 1, is characterized in that, the deletion region that described acquisition user specifies comprises: the horizontal ordinate that obtains described deletion region Origin And Destination.
3. chromatography treatment according to claim 2, it is characterized in that, judge that the summit that whether comprises peak in described deletion region comprises: judge whether the horizontal ordinate on the summit at described peak is greater than the horizontal ordinate of described deletion region starting point, and whether be less than the horizontal ordinate of described deletion region terminal.
4. chromatography treatment according to claim 1, is characterized in that, judges that the summit that whether comprises peak in described deletion region comprises: judge whether the maximum value at peak described in described deletion region equals the ordinate on the summit at described peak.
5. chromatography treatment according to claim 1, is characterized in that, described method also comprises: whether detection baseline exists and run through; If so, adjust starting point or the terminal at peak.
6. a chromatograph, is characterized in that, described chromatograph comprises:
Receiving element, judging unit and performance element;
The deletion region that described receiving element is specified for obtaining user;
Described judging unit is for judging whether described deletion region comprises the summit at peak; If so, delete described peak by described performance element.
7. a kind of chromatograph according to claim 6, is characterized in that, described receiving element is specifically for obtaining the horizontal ordinate of described deletion region Origin And Destination.
8. a kind of chromatograph according to claim 7, is characterized in that, whether described judging unit is greater than the horizontal ordinate of described deletion region starting point specifically for the horizontal ordinate on the summit that judges described peak, and whether is less than the horizontal ordinate of described deletion region terminal.
9. a kind of chromatograph according to claim 6, is characterized in that, described judging unit is specifically for judging whether the maximum value at peak described in described deletion region equals the ordinate on the summit at described peak.
10. a kind of chromatograph according to claim 6, is characterized in that, described chromatograph also comprises:
Detecting unit and adjustment unit;
Whether described detecting unit exists and runs through for detection of baseline; If so, adjusted starting point or the terminal at peak by described adjustment unit.
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| CN201210535718.1A CN103868998B (en) | 2012-12-12 | 2012-12-12 | A kind of chromatography treatment and chromatograph |
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| US20140260586A1 (en) * | 2013-03-14 | 2014-09-18 | Schlumberger Technology Corporation | Method to perform rapid formation fluid analysis |
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| US6112161A (en) * | 1997-09-17 | 2000-08-29 | Hewlett-Packard | Method, apparatus, and article of manufacture for enhanced intergration of signals |
| US20050285023A1 (en) * | 2004-06-23 | 2005-12-29 | Lambda Solutions, Inc. | Automatic background removal for input data |
| JP4614002B2 (en) * | 2006-06-08 | 2011-01-19 | 株式会社島津製作所 | Data processing equipment for chromatographic mass spectrometry |
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| US20140260586A1 (en) * | 2013-03-14 | 2014-09-18 | Schlumberger Technology Corporation | Method to perform rapid formation fluid analysis |
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