CN103860833A - Chinese herbal medicine mixture for treating intestinal nematode infection - Google Patents
Chinese herbal medicine mixture for treating intestinal nematode infection Download PDFInfo
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- CN103860833A CN103860833A CN201410081335.0A CN201410081335A CN103860833A CN 103860833 A CN103860833 A CN 103860833A CN 201410081335 A CN201410081335 A CN 201410081335A CN 103860833 A CN103860833 A CN 103860833A
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- 239000000203 mixture Substances 0.000 title claims abstract description 25
- 230000000968 intestinal effect Effects 0.000 title claims abstract description 22
- 208000000291 Nematode infections Diseases 0.000 title claims abstract description 15
- 241000411851 herbal medicine Species 0.000 title abstract 3
- 239000003814 drug Substances 0.000 claims description 20
- 230000000694 effects Effects 0.000 abstract description 12
- 241000244206 Nematoda Species 0.000 abstract description 5
- 238000006243 chemical reaction Methods 0.000 abstract description 5
- 206010062701 Nematodiasis Diseases 0.000 abstract description 3
- 238000002360 preparation method Methods 0.000 abstract description 2
- 241001465677 Ancylostomatoidea Species 0.000 abstract 2
- 241000244185 Ascaris lumbricoides Species 0.000 abstract 2
- 244000291564 Allium cepa Species 0.000 abstract 1
- 235000002732 Allium cepa var. cepa Nutrition 0.000 abstract 1
- 241000382455 Angelica sinensis Species 0.000 abstract 1
- 241000283690 Bos taurus Species 0.000 abstract 1
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- 244000294611 Punica granatum Species 0.000 abstract 1
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- 241000246044 Sophora flavescens Species 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
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- 244000045947 parasite Species 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- HXHWSAZORRCQMX-UHFFFAOYSA-N albendazole Chemical compound CCCSC1=CC=C2NC(NC(=O)OC)=NC2=C1 HXHWSAZORRCQMX-UHFFFAOYSA-N 0.000 description 8
- 229960002669 albendazole Drugs 0.000 description 7
- 102000002322 Egg Proteins Human genes 0.000 description 4
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- 208000015181 infectious disease Diseases 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 229960003439 mebendazole Drugs 0.000 description 2
- BAXLBXFAUKGCDY-UHFFFAOYSA-N mebendazole Chemical compound [CH]1C2=NC(NC(=O)OC)=NC2=CC=C1C(=O)C1=CC=CC=C1 BAXLBXFAUKGCDY-UHFFFAOYSA-N 0.000 description 2
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- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 description 1
- AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 description 1
- SPBDXSGPUHCETR-JFUDTMANSA-N 8883yp2r6d Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O[C@@H]([C@@H](C)CC4)C(C)C)O3)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 SPBDXSGPUHCETR-JFUDTMANSA-N 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a Chinese herbal medicine mixture for treating intestinal nematode infection. Ascaris lumbricoides, hookworms and whipworms are the most common intestinal nematodes and enable a human body to be in intestinal nematode infection or intestinal nematodiasis. With the adoption of the Chinese herbal medicine mixture, aiming at the characteristics of the intestinal nematode infection, pomegranate rinds, sophora flavescens ait, cyrtomium fortunei, fistular onion stalk, angelica sinensis, phellodendron and radix aucklandiae as traditional Chinese medicines are selected to prepare a mixture according to the traditional preparation method; by clinical experiment, the egg negative conversion rates of the mixture to the hookworms, the ascaris lumbricoides and the whipworms are respectively 82.0 percent, 100 percent and 68.0 percent and are obviously superior to those in a contrast group which are 49.2 percent, 80.4 percent and 23.5 percent; and the egg reduction rate of each treating group is also obviously superior to that in the contrast group, and the side effect is weak.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of herb mixture for the treatment of intestinal nematode infection.
Background technology
Ascarid, ancylostome and whipworm are modal several intestinal nematodes, can cause intestinal nematode infection or the Intestinal Nematode Infections of human body.The functions such as the immunomodulating of clinical manifestation and worm kind, quantity and the human body of infection are relevant.Some people can be without clinical symptoms, is intestinal nematode infection person, can constantly spread cause of disease; Symptomatic is intestinal nematodes patient.
The infected and trouble patient all need to treat in time.In prevention and treatment, conventional albendazole and mebendazole is all benzimidazole medicine, mebendazole is applicable to Simple infection or the mixed infection of nematicide, dosage and the course for the treatment of are depending on the weight of worm kind, infectiosity, first and second dosage is unsuitable excessive, daily dose sub-service is like better than decoction being taken at a draught, and side effect is slight.When a large amount of anthelmintic of child of severe roundworm infection, can there is of short duration diarrhoea and abdominal colic, after drug withdrawal, can recover normal.Albendazole be up-to-date one across guiding principle broad-spectrum de-worming medicine, nematicide adult, ancylostome, whipworm and roundworm egg are all killed or inhibitory action.But these two kinds of medicine life-time service, often occur side effect such as xerostomia, dizziness, headache, abdominal distention, stomachache, erythra.Applicant finds through clinical practice for many years, utilize treatment by Chinese herbs intestinal nematode infection not only to have good curative effect, and side effect is little.
Summary of the invention
The object of this invention is to provide a kind of herb mixture for the treatment of intestinal nematode infection.
The object of the invention is to be achieved through the following technical solutions, the herb mixture of this treatment intestinal nematode infection is made up of the Chinese medicine of following weight portion: Pericarpium Granati 5-10 part, Radix Sophorae Flavescentis 3-7 part, Rhizoma Osmundae 3-7 part, Bulbus Allii Fistulosi 10-15 part, Radix Angelicae Sinensis 7-10 part, Cortex Phellodendri 10-15 part, Radix Aucklandiae 3-5 part.
Preferably, 7 parts of Pericarpium Granatis, 5 parts of Radix Sophorae Flavescentiss, 5 parts of Rhizoma Osmundae, 13 parts of Bulbus Allii Fistulosi, 9 parts of Radix Angelicae Sinensis, 13 parts of Cortex Phellodendris, 4 parts of the Radix Aucklandiae.
Preparation method: medicine-feeding is decocted with water 2 times, 25 minutes for the first time, leach medicinal liquid; For the second time medicinal residues are added to decocting in water 40 minutes, leach medicinal liquid.Then 2 medicinal liquids are merged, filter and obtain mixture.
The pharmacological action of each taste Chinese medicine:
Pericarpium Granati relieving diarrhea with astringents, hemostasis anthelmintic; Radix Sophorae Flavescentis heat clearing and damp drying, wind dispelling insecticide; Rhizoma Osmundae heat-clearing and toxic substances removing, hemostasis parasite killing; Bulbus Allii Fistulosi is delivered and is activated yang, removing toxic substances parasite killing; Radix Aucklandiae promoting the circulation of QI to relieve pain, intestinal stasis relieving in tune; Chinese angelica blood supplementing is invigorated blood circulation, and laxation is moisturized in pain relieving; Cortex Phellodendri heat clearing and damp drying.
Clinical data
1, treatment target is selected the more serious rural area of intestinal nematode infection, Qingdao of Shandong province, and the age is carried out to fecal the villager in 10-60 year, adopts improvement to add Teng Shi method (kato-lcatz) and does qualitative, quantitative inspection.Ascarid and whipworm infection, egg count require more than 20 and 5 person as selected object.Before treatment, all make blood, urine. stool routine, hepatic and renal function and Electrocardioscopy.Through health check-up without serious organic illness and pregnant person as treatment target.
2, Therapeutic Method
MethodsThe cases enrolled is made layer and section random packet by infected insect species, sex.And make random double blind test, and clinical treatment group and matched group, clinical treatment group, again according to the difference of infected insect species, is divided into hookworm infection treatment group, roundworm infection treatment group and whipworm infection treatment group.
Clinical treatment group is taken herb mixture treatment of the present invention, take Pericarpium Granati 70g, Radix Sophorae Flavescentis 50g, Rhizoma Osmundae 50g, Bulbus Allii Fistulosi 130g, Radix Angelicae Sinensis 90g, Cortex Phellodendri 130g, Radix Aucklandiae 40g, above-mentioned raw materials medicine is decocted with water 2 times, the ratio of crude drug and water is 1: 5, after boiling for the first time, slow fire boiling 25 minutes again, leaches medicinal liquid; For the second time medicinal residues are added to decocting in water 40 minutes, leach medicinal liquid, then 2 medicinal liquids are merged, filter and obtain mixture, morning is decoction being taken at a draught on an empty stomach, each 200ml that is grown up, and child reduces by half; Albendazole In Treatment for matched group (every of albendazole contains 200mg, and Minsheng Pharmaceutical Group Co., Hangzhou produces, lot number 980218), morning is decoction being taken at a draught 400mg on an empty stomach.
3, efficacy assessment
Drug therapy adopts kato-katz method to add saturated saline floatation to carry out two and send four inspections checks in 1 month, the equal negative patient of worm's ovum is decided to be the moon and turns (healing), the foundation using worm's ovum negative conversion rate as Estimating curative effect.
Each treatment group and matched group respectively select 5 cases, and after taking medicine, collect full dose feces every day, washes in a pan day by day worm by tamisage, identifies worm kind counting, records parasite removing situation.
Each treatment group and matched group before controlling, control after 24h all check hemogram. urine, stool routine regulating liver-QI, renal function, electrocardiogram.
4, therapeutic outcome
(1) negative conversion rate of worm's ovum negative conversion rate ancylostome, ascarid, whipworm, retrofection is in table 1.
The curative effect comparison of the each treatment group of table 1 and treatment of control group ancylostome, ascarid, whipworm and retrofection
Can find out from table 1 curative effect, herb mixture of the present invention, is respectively 82.0%, 100% and 68.0% to the worm's ovum negative conversion rate of ancylostome, ascarid, whipworm, is obviously better than 49.2%, 80.4% and 23.5% of matched group; The Redution of eggs of each treatment group is also obviously better than matched group.From parasite removing effect, to the anthelmintic action highly significant of ascarid, herb mixture parasite removing is rapid, within second day, reaches parasite removing peak, and albendazole starts parasite removing for second day, within the 3rd day, reaches peak.
(2) wash in a pan worm result and take ivermectin and the each naughty parasitosis example of albendazole and all have ancylostome, ascarid and whipworm to discharge, the results are shown in Yuan 2.
Table 2 takes traditional Chinese medicine and washes in a pan worm result after mixture and albendazole
Each test group takes traditional Chinese medicine and starts parasite removing in after mixture 12 hours, and about 30 hours, accumulative total is discharged more than 95%, ancylostome basic emptying in the 3rd day.The polypide of discharging is complete.And ascarid group still has parasite removing on the 3rd day.
Matched group takes the albendazole group latter 12 hours rarely found parasite removings of taking medicine, and mostly starts parasite removing at the 2nd day, within the 3rd day, reaches peak. the also emptying in the 3rd day of ancylostome group.
5, side effect is observed
Each test group is taken intestinal nematodes totally 239 examples such as herb mixture treatment ancylostome, occurs 2 examples of side effect after taking medicine; , there are side effect 19 examples in intestinal nematodes totally 151 examples such as treatment of control group ancylostome, 2-6 hour after side reaction all appears at and takes medicine, is of short duration stomachache, not treated dying away after taking medicine.Two groups of no abnormal variations of hemogram, liver, renal function, excrement, routine urinalysis and electrocardiogram.
The specific embodiment
Embodiment mono-: take Pericarpium Granati 70g, Radix Sophorae Flavescentis 50g, Rhizoma Osmundae 50g, Bulbus Allii Fistulosi 130g, Radix Angelicae Sinensis 90g, Cortex Phellodendri 130g, Radix Aucklandiae 40g, above-mentioned raw materials medicine is decocted with water 2 times, 25 minutes for the first time, leach medicinal liquid; For the second time medicinal residues are added to decocting in water 40 minutes, leach medicinal liquid, then 2 medicinal liquids are merged, filter and obtain mixture.
Embodiment bis-: take Pericarpium Granati 50g, Radix Sophorae Flavescentis 70g, Rhizoma Osmundae 30g, Bulbus Allii Fistulosi 100g, Radix Angelicae Sinensis 70g, Cortex Phellodendri 150g, Radix Aucklandiae 30g, above-mentioned raw materials medicine is decocted with water 2 times, 25 minutes for the first time, leach medicinal liquid; For the second time medicinal residues are added to decocting in water 40 minutes, leach medicinal liquid, then 2 medicinal liquids are merged, filter and obtain mixture.
Embodiment tri-: take Pericarpium Granati 100g, Radix Sophorae Flavescentis 30g, Rhizoma Osmundae 70g, Bulbus Allii Fistulosi 150g, Radix Angelicae Sinensis 100g, Cortex Phellodendri 100g, Radix Aucklandiae 50g, above-mentioned raw materials medicine is decocted with water 2 times, 25 minutes for the first time, leach medicinal liquid; For the second time medicinal residues are added to decocting in water 40 minutes, leach medicinal liquid, then 2 medicinal liquids are merged, filter and obtain mixture.
Claims (2)
1. treat a herb mixture for intestinal nematode infection, it is characterized in that this herb mixture is made up of the Chinese medicine of following weight portion: Pericarpium Granati 5-10 part, Radix Sophorae Flavescentis 3-7 part, Rhizoma Osmundae 3-7 part, Bulbus Allii Fistulosi 10-15 part, Radix Angelicae Sinensis 7-10 part, Cortex Phellodendri 10-15 part, Radix Aucklandiae 3-5 part.
2. a kind of herb mixture for the treatment of intestinal nematode infection as claimed in claim 1, is characterized in that this herb mixture is made up of the Chinese medicine of following weight portion: 7 parts of Pericarpium Granatis, 5 parts of Radix Sophorae Flavescentiss, 5 parts of Rhizoma Osmundae, 13 parts of Bulbus Allii Fistulosi, 9 parts of Radix Angelicae Sinensis, 13 parts of Cortex Phellodendris, 4 parts of the Radix Aucklandiae.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410081335.0A CN103860833B (en) | 2014-02-22 | 2014-02-22 | A kind of herb mixture treating intestinal nematode infection |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410081335.0A CN103860833B (en) | 2014-02-22 | 2014-02-22 | A kind of herb mixture treating intestinal nematode infection |
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| Publication Number | Publication Date |
|---|---|
| CN103860833A true CN103860833A (en) | 2014-06-18 |
| CN103860833B CN103860833B (en) | 2016-06-29 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410081335.0A Active CN103860833B (en) | 2014-02-22 | 2014-02-22 | A kind of herb mixture treating intestinal nematode infection |
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| CN (1) | CN103860833B (en) |
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2014
- 2014-02-22 CN CN201410081335.0A patent/CN103860833B/en active Active
Non-Patent Citations (1)
| Title |
|---|
| 孙克年: ""驱虫中草药的科学使用"", 《兽医导刊》, no. 8, 31 December 2007 (2007-12-31), pages 33 - 35 * |
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| CN103860833B (en) | 2016-06-29 |
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