CN103845770A - Automatic flushing device and method for blood filter - Google Patents
Automatic flushing device and method for blood filter Download PDFInfo
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- CN103845770A CN103845770A CN201210498704.7A CN201210498704A CN103845770A CN 103845770 A CN103845770 A CN 103845770A CN 201210498704 A CN201210498704 A CN 201210498704A CN 103845770 A CN103845770 A CN 103845770A
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- flushing
- filter
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- hemofilter
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/75—General characteristics of the apparatus with filters
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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Abstract
The invention discloses an automatic flushing device and method for a blood filter. The device comprises a filter and a waste liquid container and further comprises a second liquid way pipe. The filter comprises a first intra-membrane joint, a second intra-membrane joint and a third intra-membrane joint. The first intra-membrane joint is connected with a first blood way pipe, the second intra-membrane joint is connected with a second blood way pipe, and the third intra-membrane joint is connected with the waste liquid container through a first liquid way pipe. Two ends of the second liquid way pipe are communicated with the first blood way pipe and a flushing liquid container respectively, a first clamp is arranged on the first liquid way pipe, and a second clamp is arranged on the second liquid way pipe. The filter, a flushing pump and the first and second clamps are electrically connected with a control circuit which monitors the actual trans-membrane pressure of the filter and controls the operation of the flushing pump and the opening and closing of the first and second clamps.
Description
Technical field
The present invention relates to a kind of blood purification treatment system, particularly a kind of hemofilter automatic flushing device and auto-flushing method thereof.
Background technology
At traditional continuous renal replacementtherapy or more in the continuous blood purification treatment of broad sense, having a kind of important pattern is hemofiltration.Hemofiltration imitates the heavy principle of absorption design of filtration of nephron, patient's arterial blood is introduced and had in good permeability the semipermeable membrane filter suitable with glomerular filtration membrane area, in the time that blood passes through filter, moisture in blood plasma is just filtered off (similar glomerular filtration), removes retention too much moisture and therapeutic purposes of solute in blood to reach.
Because morbid substance molecular weight is between 15～3,000,000 d, molecular volume volume span is large, at present, adopts clinically Cured by Double Filtration Plasmapheresis therapy to carry out selectivity plasmapheresis, and the film filter of two different pore sizes is set in circulation in vitro, point two sections of filtration blood plasma.While carrying out blood Cured by Double Filtration Plasmapheresis therapy, under the effect of peristaltic pump, the plasma fraction in blood is separated from the first heavy filter, enters the second heavy filter.Because of the effect of the second heavy filter hollow fiber film structure, small-molecule substance (useful component) in blood plasma can normally pass through and defeated the Huis' body, macromolecular substances (pathology composition) is trapped within the second heavy filter hollow-fibre membrane, realizes the therapeutic purposes of removing pathology composition in blood.
But, along with the carrying out for the treatment of, the macromolecular substances in the second heavy filter hollow-fibre membrane can increase gradually, causes the second heavy filter doughnut fenestra to be stopped up gradually by macromolecular substances, the second heavy filter transmembrane pressure is raise, and the small-molecule substance in blood plasma also cannot normally pass through defeated the Huis' body.So this therapy is carried out in process, need to remove the macromolecular substances of a side in the second heavy filter hollow-fibre membrane, the continuing of guarantee course for the treatment of carries out.
As shown in Figure 1, the conventional sweep-out method medically adopting is at present an external peristaltic pump 92 on the second heavy filter 91, and peristaltic pump 92 entrances are a side in the second heavy filter 91 hollow-fibre membranes, export as waste fluid container 93.Therapy is carried out in process, peristaltic pump 92 is with lower than the continuous running of blood plasma flowing velocity (peristaltic pump 92 rotating speeds or flow can artificially regulate), the macromolecular substances that the second heavy filter 91 hollow-fibre membrane inner sides are held back is discharged, make it to enter waste fluid container 93, thus ensure therapy continue carry out.
This " rinsing routinely " method is a continous way reset procedure, the continuous running of peristaltic pump 92, though can prevent the second heavy filter 91 Pore Blockings, ensure the course for the treatment of continue carry out, but can cause more plasma fraction (including the small-molecule substance of use) in the second heavy filter 91 films to be pumped in waste fluid container 93, can not feed back human body, cause the loss of patient's blood plasma large, when therapy is carried out, need to supplement separately blood plasma.
Summary of the invention
The hemofilter automatic flushing device and the auto-cleaning method thereof that provide a kind of patient's of minimizing blood plasma to run off are mainly provided object of the present invention.
For achieving the above object, the present invention is by the following technical solutions:
The invention provides a kind of hemofilter automatic flushing device, comprise filter and waste fluid container, described filter has the first film nipple, the second film nipple and tertiary membrane nipple, described the first film nipple is connected with the first blood vessel, described the second film nipple is connected with the second blood vessel, tertiary membrane nipple is communicated with described waste fluid container by the first influidic pipe, hemofilter automatic flushing device also includes the second influidic pipe, the two ends of described the second influidic pipe are communicated with respectively described the first blood vessel and described flushing liquor container, on described the first influidic pipe, the first clamp is installed, on described the second blood vessel, the second clamp is installed, described filter, described flushing pump and described first, the second clamp is electrically connected with control circuit respectively, described control circuit is monitored the actual transmembrane pressure of described filter and is controlled described flushing pump running and described first, the opening and closing of the second clamp.
As the further improvement of such scheme, the mobile flushing pump that power is provided of promising flushing liquid is set on described the second influidic pipe.
Further, described filter is connected with described control circuit by wire, described control circuit is monitored the actual transmembrane pressure of described filter, and rinse transmembrane pressure value, irrigation flow rate and flushing liquor total amount by described control circuit control, the time that flushing pump turns round in the time that transmembrane pressure arrives predetermined value time delay described in described control circuit control.
Further, described first, second clamp and described control circuit are electrically connected, open and close when different when first, second clamp is different described in described control circuit control, and time of the first clamp time-delay closing described in described control circuit control.
The present invention also provides a kind of and utilizes hemofilter automatic flushing device of the present invention to carry out the method for hemofilter auto-flushing, comprises the following steps:
A. set flushing transmembrane pressure value, irrigation flow rate and the flushing liquor total amount of filter;
B. when hemofiltration therapy is normally carried out, flushing pump does not turn round, to stop the blood plasma in the first blood vessel to flow into flushing liquor container via described the second influidic pipe; The first clamp is closed, to stop the blood plasma in filter to flow into waste fluid container via described the first influidic pipe; The second clamp is open, so that the blood plasma in filter can be via the second blood vessel human body that normally refluxes;
C. in the time that filter transmembrane pressure arrives setting flushing transmembrane pressure value, trigger flushing process: the first clamp is open, and the second clamp is closed, flushing pump entry into service, flushing liquor flows through in filter film according to setting flow velocity, brings macromolecular substances in film into waste fluid container;
D. in the time that flushing liquor total amount arrives setting value, enter step b.
As the further improvement of such scheme, in step a, also comprise that setting flushing pump arrives time that setting value turns round when time delay and the time of the second clamp time-delay closing at transmembrane pressure, correspondingly, in step c, when filter transmembrane pressure arrives, transmembrane pressure value is rinsed in setting and after above-mentioned delay time arrives, described flushing pump entry into service, the second clamp are closed.
Further, in the process of carrying out to steps d at step b, carry out step a.
Compared with prior art, hemofilter automatic flushing device of the present invention is monitored the actual transmembrane pressure of described filter by described control circuit and is controlled opening and closing of described flushing pump running and described first, second clamp, make in the time that therapy is normally carried out, can optionally open or close described first, second clamp, thereby realize intermittent cleaning process; Hemofilter auto-flushing method of the present invention, whole system is just rinsed after the actual transmembrane pressure of filter reaches setting value, in the time that arriving setting value, flushing liquor total amount stops again cleaning, system is carried out normal hemofiltration therapy, this intermittent cleaning process can reduce blood plasma in filter and run off, the effect that reaches without or supplement separately on a small quantity blood plasma.
Brief description of the drawings
Fig. 1 is the structure principle chart of rinser routinely in prior art;
Fig. 2 is the structure chart of hemofilter automatic flushing device of the present invention.
Detailed description of the invention
For ease of better understanding object of the present invention, structure, feature and effect etc., existing the invention will be further described with detailed description of the invention by reference to the accompanying drawings.
With reference to Fig. 2, hemofilter automatic flushing device of the present invention, comprises filter 1, waste fluid container 2, flushing liquor container 3 and flushing pump 4.In the present embodiment, described filter 1 is the heavy filter of second in double filtration therapy, it has the first film nipple 11, the second film nipple 12 and tertiary membrane nipple 13, described the first film nipple 11 is connected with the first blood vessel 51, described the second film nipple 12 is connected with the second blood vessel 52, and tertiary membrane nipple 13 is communicated with described waste fluid container 2 by the first influidic pipe 61.Hemofilter automatic flushing device of the present invention also includes the second influidic pipe 62, the two ends of described the second influidic pipe 62 are communicated with respectively described the first blood vessel 51 and described flushing liquor container 3, and the mobile described flushing pump 4 that power is provided of promising flushing liquid is set on described the second influidic pipe 62.Wherein, on described the first influidic pipe 61 and described the second blood vessel 52, be separately installed with the first clamp 71 and the second clamp 72, described the first clamp 71 is closed in the time that therapy is normally carried out, it is open in the time that flushing liquor flows, described the second clamp 72 is open in the time that therapy is normally carried out, and in the time that flushing liquor flows, closes.
Hemofilter automatic flushing device of the present invention also comprises control circuit 8.Described control circuit 8 is electrically connected by wire and described filter 1, and described control circuit 8 is in order to monitor the actual transmembrane pressure of described filter 1; Described control circuit 8 is also electrically connected by wire with described flushing pump 4, in order to control flushing transmembrane pressure value, irrigation flow rate and the flushing liquor total amount of described flushing pump 4, described control circuit 8 also turns round and controls the time that described flushing pump 4 turns round in the time that actual transmembrane pressure (film internal pressure and film external pressure meansigma methods poor) arrives predetermined value time delay for controlling described flushing pump 4; Described control circuit 8 is also electrically connected by wire with described the first clamp 71, the second clamp 72, in order to control described the first clamp 71,, the opening and closing of the second clamp 72, and can control the time of described the first clamp 71 time-delay closings.
The method that uses hemofilter automatic flushing device of the present invention to carry out hemofilter auto-flushing is as follows:
First, operator can arrange and rinse transmembrane pressure value and irrigation flow rate, flushing liquor total amount according to situations such as the kind of described filter 1, patient's plasma fractions, run off for reducing blood plasma, operator also can arrange the time that described flushing pump 4 turns round in the time that transmembrane pressure reaches setting value time delay, and the time of described the second clamp 72 time-delay closings, these two time delays can ensure that the blood plasma in described filter 1 film is farthest fed back to patient's human body.Above-mentioned setting all realized by described control circuit 8.
Then, Cured by Double Filtration Plasmapheresis therapy is carried out.In the time that therapy is normally carried out, described flushing pump 4 does not turn round, to stop undressed blood plasma in the first blood vessel 51 to flow into flushing liquor container 3 via described the second influidic pipe 62; Described the first clamp 71 is closed, to stop the blood plasma in described filter 1 to flow into described waste fluid container 2 via described the first influidic pipe 61; Described the second clamp 72 is open, so that the interior treated blood plasma of described filter 1 can normally flow back to human body via described the second blood vessel 52.
Along with the carrying out of therapy, the macromolecular substances in described filter 1 film inner accumulated blood plasma, the actual transmembrane pressure of described filter 1 raises gradually, and in this process, described control circuit 8 keeps the actual transmembrane pressure of the described filter 1 of monitoring.In the time that described control circuit 8 monitors the flushing transmembrane pressure value of actual transmembrane pressure arrival operator setting of described filter 1, system triggers flushing process automatically.Now, described control circuit 8 is controlled open described the first clamp 71, but described the second clamp 72 still in open state, described flushing pump 4 in halted state so that described filter 1 film in remaining blood plasma can continue normally to flow back to human body through described the second blood vessel 52.
The time that the described flushing pump 4 of setting as operator turns round in the time that transmembrane pressure arrives setting value time delay, and after the time arrival of the second clamp 72 time-delay closings, in described filter 1 film, useful small-molecule substance has stopped less, now described control circuit 8 controls and cuts out described the second clamp 72, described flushing pump 4 entrys into service, flushing pump 4 provides power for flushing liquid flows, make flushing liquor by the irrigation flow rate of setting according to operator in described the second influidic pipe 62 flows into described filter 1 film, and bring macromolecular substances in film into described waste fluid container 2 via described the first influidic pipe 61, realize good cleaning process.
When after the flushing liquor total amount that system complete operation person sets, described control circuit 8 controls that described flushing pump 4 shuts down, described the first clamp 71 is closed, described the second clamp 72 is open, proceed the course for the treatment of, until the actual transmembrane pressure of described filter 1 triggers flushing process after again reaching the flushing transmembrane pressure value of setting again, repeat above-mentioned flushing process in batch (-type) mode.
In addition,, in the process of carrying out in therapy, operator can also modify to rinsing transmembrane pressure value, irrigation flow rate and flushing liquor total amount.
The intermittent cleaning process of hemofilter automatic flushing device of the present invention and purging method thereof can reduce the interior blood plasma of filter 1 and run off, clinical trial prove blood plasma run off be less than 150ml, use hemofilter automatic flushing device of the present invention and purging method thereof without or on a small quantity separately supplement blood plasma.
More than describe the only explanation for the present invention's preferred embodiment in detail, non-ly therefore limit to the scope of the claims of the present invention, so the so-called equivalence techniques variation of all this creation of utilization description and diagramatic content is all contained in the scope of the claims of the present invention.
Claims (10)
1. a hemofilter automatic flushing device, comprise filter and waste fluid container, described filter has the first film nipple, the second film nipple and tertiary membrane nipple, described the first film nipple is connected with the first blood vessel, described the second film nipple is connected with the second blood vessel, tertiary membrane nipple is communicated with described waste fluid container by the first influidic pipe, it is characterized in that: also include the second influidic pipe, the two ends of described the second influidic pipe are communicated with respectively described the first blood vessel and described flushing liquor container, on described the first influidic pipe, the first clamp is installed, on described the second blood vessel, the second clamp is installed, described filter, described flushing pump and described first, the second clamp is electrically connected with control circuit respectively, described control circuit is monitored the actual transmembrane pressure of described filter and is controlled described flushing pump running and described first, the opening and closing of the second clamp.
2. hemofilter automatic flushing device as claimed in claim 1, is characterized in that: the mobile flushing pump that power is provided of promising flushing liquid is set on described the second influidic pipe.
3. hemofilter automatic flushing device as claimed in claim 1, is characterized in that: described filter is connected with described control circuit by wire, and described control circuit is monitored the actual transmembrane pressure of described filter.
4. hemofilter automatic flushing device as claimed in claim 1, is characterized in that: described flushing pump is electrically connected by wire and described control circuit, and transmembrane pressure value, irrigation flow rate and flushing liquor total amount are rinsed in described control circuit control.
5. hemofilter automatic flushing device as claimed in claim 1, is characterized in that: the time that described in described control circuit control, flushing pump turns round in the time that transmembrane pressure arrives predetermined value time delay.
6. hemofilter automatic flushing device as claimed in claim 1, is characterized in that: described first, second clamp and described control circuit are electrically connected, open and close when different when first, second clamp is different described in described control circuit control.
7. hemofilter automatic flushing device as claimed in claim 6, is characterized in that: the time of the first clamp time-delay closing described in described control circuit control.
8. right to use requires the hemofilter automatic flushing device described in 1 to carry out a method for hemofilter auto-flushing, it is characterized in that, comprises the following steps:
A. set flushing transmembrane pressure value, irrigation flow rate and the flushing liquor total amount of filter;
B. when hemofiltration therapy is normally carried out, flushing pump does not turn round, to stop the blood plasma in the first blood vessel to flow into flushing liquor container via described the second influidic pipe; The first clamp is closed, and stops the blood plasma in filter to flow into waste fluid container via described the first influidic pipe; The second clamp is open, so that the blood plasma in filter can be via the second blood vessel human body that normally refluxes;
C. in the time that filter transmembrane pressure arrives setting flushing transmembrane pressure value, trigger flushing process: the first clamp is open, and the second clamp is closed, flushing pump entry into service, flushing liquor flows through in filter film according to setting flow velocity, brings macromolecular substances in film into waste fluid container;
D. in the time that flushing liquor total amount arrives setting value, enter step b.
9. hemofilter auto-flushing method as claimed in claim 8, it is characterized in that: in step a, also comprise that setting flushing pump arrives time that setting value turns round when time delay and the time of the second clamp time-delay closing at transmembrane pressure, correspondingly, in step c, in the time that filter transmembrane pressure arrives setting flushing transmembrane pressure value, and after above-mentioned delay time arrives, described flushing pump entry into service, the second clamp are closed.
10. hemofilter auto-flushing method as claimed in claim 8 or 9, is characterized in that: in the process of carrying out to steps d at step b, carry out step a.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210498704.7A CN103845770A (en) | 2012-11-29 | 2012-11-29 | Automatic flushing device and method for blood filter |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210498704.7A CN103845770A (en) | 2012-11-29 | 2012-11-29 | Automatic flushing device and method for blood filter |
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| CN103845770A true CN103845770A (en) | 2014-06-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201210498704.7A Pending CN103845770A (en) | 2012-11-29 | 2012-11-29 | Automatic flushing device and method for blood filter |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113577423A (en) * | 2021-07-13 | 2021-11-02 | 健帆生物科技集团股份有限公司 | Priming method for blood purification device, blood purification device and storage medium |
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| CN1803207A (en) * | 2006-01-10 | 2006-07-19 | 赵滨宇 | Hematodialysis circulating device |
| CN101524625A (en) * | 2009-03-31 | 2009-09-09 | 大连理工大学 | Cleaning method of porous separation membrane |
| CN101678161A (en) * | 2007-04-12 | 2010-03-24 | 甘布罗伦迪亚股份公司 | Method and apparatus for priming an extracorporeal blood circuit |
| US20100168925A1 (en) * | 2006-06-08 | 2010-07-01 | Peter Hilgers | Device and method for controlling an extracorporeal blood- treating apparatus |
| CN202207346U (en) * | 2011-08-04 | 2012-05-02 | 黄昱 | Portable blood purifying system |
-
2012
- 2012-11-29 CN CN201210498704.7A patent/CN103845770A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1803207A (en) * | 2006-01-10 | 2006-07-19 | 赵滨宇 | Hematodialysis circulating device |
| US20100168925A1 (en) * | 2006-06-08 | 2010-07-01 | Peter Hilgers | Device and method for controlling an extracorporeal blood- treating apparatus |
| CN101678161A (en) * | 2007-04-12 | 2010-03-24 | 甘布罗伦迪亚股份公司 | Method and apparatus for priming an extracorporeal blood circuit |
| CN101524625A (en) * | 2009-03-31 | 2009-09-09 | 大连理工大学 | Cleaning method of porous separation membrane |
| CN202207346U (en) * | 2011-08-04 | 2012-05-02 | 黄昱 | Portable blood purifying system |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113577423A (en) * | 2021-07-13 | 2021-11-02 | 健帆生物科技集团股份有限公司 | Priming method for blood purification device, blood purification device and storage medium |
| CN113577423B (en) * | 2021-07-13 | 2024-05-31 | 健帆生物科技集团股份有限公司 | Pre-flushing method of blood purification device, blood purification device and storage medium |
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Application publication date: 20140611 |