CN103845696A - Traditional Chinese medicine composition for treating leukemia as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating leukemia as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating leukemia. The composition is prepared from pteris multifida, Japanese cayratia herb, evergreen mucuna roots and leaves, Teucrium pilosum, mangnolia officinalis, dandelion, semen coicis, cinnamon, hupeh bauhinia roots, schisandra chinensis, cassia twig, inula flowers, radix curcumae, pericarpium citri reticulatae, eucommia ulmoides, dogwood, tuber fleeceflower stems, exocarpium benincasae, leonurus, rhizoma acori graminei, radix achyranthis bidentatae and plantain herb. The invention further provides a preparation method and an application of the traditional Chinese medicine composition for treating leukemia. The traditional Chinese medicine composition for treating leukemia provided by the invention has the functions of clearing away heat and toxic materials and tonifying qi and invigorating yang, and not only can eliminate pathogenic factors, but also can strengthen the body resistance, so that the composition eliminates pathogenic factors but does not damage the body and strengthens the body resistance but does not reserve pathogenic factors, and synergically exerts the effect of strengthening the body resistance to resist cancer. Therefore, the composition has a good curative effect.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to one and treat leukemic Chinese medicine composition.
Background technology
Leukaemia has multiplication capacity, but differentiation, anacmesis are built up leukaemia in bone marrow, suppress normal hematopoiesis cell proliferation in hemopoietic tissue, apoptosis participates in hematopoietic regulation, maintains stablizing of hemopoietic and dead dynamic equilibrium and Peripheral blood cell number.Find by the research that regulates apoptosis of leukemia: polytype white and sick cell can be in vivo or the external effect through various compounds there is end differentiation and apoptosis eventually, this is the basis of white and sick apoptosis-induced treatment, also for white and sick new means and the approach that provide is provided.
Summary of the invention
The object of this invention is to provide one and treat leukemic Chinese medicine composition.
In order to realize object of the present invention, the invention provides one and treat leukemic Chinese medicine composition, it is to be made up by weight of following bulk drugs: well limit grass 1-10 part, Herba Cayatiae Japonicae 1-10 part, Radix Seu Caulis Mucunae Sempervirentis 1-10 part, Tucrium Pilosum 1-10 part, Cortex Magnoliae Officinalis 1-10 part, Herba Taraxaci 1-10 part, Semen Coicis 1-10 part, Cortex Cinnamomi 1-10 part, Radix Bauhiniae Hupehanae 1-10 part, Fructus Schisandrae Chinensis 1-10 part, Ramulus Cinnamomi 1-10 part, Flos Inulae 1-10 part, Radix Curcumae 1-10 part, Pericarpium Citri Reticulatae 1-10 part, Cortex Eucommiae 1-10 part, Fructus Corni 1-10 part, Caulis Polygoni Multiflori 1-10 part, Exocarpium Benincasae 1-10 part, Herba Leonuri 1-10 part, Rhizoma Acori Graminei 1-10 part, Radix Achyranthis Bidentatae 1-10 part and Herba Plantaginis 1-10 part.
Preferably, the leukemic Chinese medicine composition for the treatment of of the present invention is to be made up by weight of following bulk drugs: (medical material Ji Yuan is rhizome or the herb of the coarse Herba Pteridis creticae of Pteridaceae plant to Jing Biancao, Latin plant animal mineral name Pteris cretica L.var.laeta (Wall.) C.Chr.et Tard.-Blot[P.laeta Wall.]) 8 parts, 6 parts of Herba Cayatiae Japonicaes (Latin formal name used at school Cayratia japonica (Thunb.) Gagnep.), 10 parts of Radix Seu Caulis Mucunae Sempervirentis (Latin formal name used at school Mucuna sempervirens Hemsl), 9 parts of Tucrium Pilosums (Latin formal name used at school Teucrium pilosum (Pamp.) C.Y.Wu et S.Chow), 8 parts of Cortex Magnoliae Officinalis, 6 parts of Herba Taraxacis, 7 parts of Semen Coiciss, 6 parts of Cortex Cinnamomis, (medical material Ji Yuan is pulse family bauhinia bauhinia hupehana Craib Bauhinia hupehana Craib to Radix Bauhiniae Hupehanae, be used as medicine with root or stem and leaf) 5 parts, 6 parts of Fructus Schisandrae Chinensis, 6 parts of Ramulus Cinnamomi, 4 parts of Flos Inulaes, 3 parts of Radix Curcumaes, 4 parts of Pericarpium Citri Reticulataes, 3 parts of the Cortexs Eucommiae, 2 parts of Fructus Corni, 2 parts of Caulis Polygoni Multiflori, 3 parts of Exocarpium Benincasaes, 2 parts of Herba Leonuris, 1 part of Rhizoma Acori Graminei, 2 parts of Radix Achyranthis Bidentataes, 1 part of Herba Plantaginis.
More preferably, described Chinese medicine composition can be tablet, dispersible tablet, buccal tablet, instant, disintegrating tablet, capsule, powder or decoction.
The present invention also provides a kind of preparation method for the treatment of leukemic Chinese medicine composition, the method comprises the following steps: to get Jing Biancao, Herba Cayatiae Japonicae, Radix Seu Caulis Mucunae Sempervirentis, Tucrium Pilosum, Cortex Magnoliae Officinalis, Herba Taraxaci, Semen Coicis, Cortex Cinnamomi, Radix Bauhiniae Hupehanae, Fructus Schisandrae Chinensis, Ramulus Cinnamomi, Flos Inulae, Radix Curcumae, Pericarpium Citri Reticulatae, the Cortex Eucommiae, Fructus Corni, Caulis Polygoni Multiflori, Exocarpium Benincasae, Herba Leonuri, Rhizoma Acori Graminei, Radix Achyranthis Bidentatae and Herba Plantaginis, add 2 liters, water, under the condition refluxing, heat 5 hours, filter, collect filtrate and be cooled to room temperature.
The present invention also provides the application of Chinese medicine composition in the leukemic medicine of preparation treatment, described Chinese medicine composition is to be made up by weight of following bulk drugs: well limit grass 1-10 part, Herba Cayatiae Japonicae 1-10 part, Radix Seu Caulis Mucunae Sempervirentis 1-10 part, Tucrium Pilosum 1-10 part, Cortex Magnoliae Officinalis 1-10 part, Herba Taraxaci 1-10 part, Semen Coicis 1-10 part, Cortex Cinnamomi 1-10 part, Radix Bauhiniae Hupehanae 1-10 part, Fructus Schisandrae Chinensis 1-10 part, Ramulus Cinnamomi 1-10 part, Flos Inulae 1-10 part, Radix Curcumae 1-10 part, Pericarpium Citri Reticulatae 1-10 part, Cortex Eucommiae 1-10 part, Fructus Corni 1-10 part, Caulis Polygoni Multiflori 1-10 part, Exocarpium Benincasae 1-10 part, Herba Leonuri 1-10 part, Rhizoma Acori Graminei 1-10 part, Radix Achyranthis Bidentatae 1-10 part and Herba Plantaginis 1-10 part.
Preferably, described Chinese medicine composition is to be made up by weight of following bulk drugs: 1 part of 8 parts of well limit grass, 6 parts of Herba Cayatiae Japonicaes, 10 parts of Radix Seu Caulis Mucunae Sempervirentis, 9 parts of Tucrium Pilosums, 8 parts of Cortex Magnoliae Officinalis, 6 parts of Herba Taraxacis, 7 parts of Semen Coiciss, 6 parts of Cortex Cinnamomis, 5 parts of Radix Bauhiniae Hupehanaes, 6 parts of Fructus Schisandrae Chinensis, 6 parts of Ramulus Cinnamomi, 4 parts of Flos Inulaes, 3 parts of Radix Curcumaes, 4 parts of Pericarpium Citri Reticulataes, 3 parts of the Cortexs Eucommiae, 2 parts of Fructus Corni, 2 parts of Caulis Polygoni Multiflori, 3 parts of Exocarpium Benincasaes, 2 parts of Herba Leonuris, 1 part of Rhizoma Acori Graminei, 2 parts of Radix Achyranthis Bidentataes and Herba Plantaginis.
Generally acknowledged that at present " organic conception ", " determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs ", " compound recipe use ", " compound compatibility medication is as used military forces " are the most scientific the most several large advantages of the traditional Chinese medical science, wherein " compound compatibility medication is as used military forces " is the original theory of Chinese medicine of very science.Each medicine tight compatibility all linked with one another as arrayed troops for battle in traditional Chinese medical science prescription is its effective means that is better than Western medicine formula.Tcm prescription theory is thought, each prescription, not only need to select the appropriate compatibility of suitable medicine according to etiology and pathogenesis, also should meet the basic structure of prescription simultaneously, the i.e. prescription compatibility theory of " monarch, minister, help, make ", the prescription compatibility of so-called " monarch, minister, help, make " is exactly that it is based upon the scientific matching on the comprehensive judgement basis of disease pathogenesis.In medical square tube cross too many levels, many target spots and integrate the biological mechanism regulating, can obtain than Western medicine more lastingly, therapeutic effect that more green natural has no side effect, and this curative effect is to be based upon on the accurate instruction of the original theory of above-mentioned traditional Chinese medical science tradition, the present invention is just following this principle.
In the present composition, Jing Biancao, Herba Cayatiae Japonicae, Radix Seu Caulis Mucunae Sempervirentis and Tucrium Pilosum are monarch drug; Cortex Magnoliae Officinalis, Herba Taraxaci, Semen Coicis, Cortex Cinnamomi, Radix Bauhiniae Hupehanae, Fructus Schisandrae Chinensis and Ramulus Cinnamomi are ministerial drug; Flos Inulae, Radix Curcumae, Pericarpium Citri Reticulatae, the Cortex Eucommiae, Fructus Corni and Caulis Polygoni Multiflori are adjuvant drug; Exocarpium Benincasae, Herba Leonuri, Rhizoma Acori Graminei, Radix Achyranthis Bidentatae and Herba Plantaginis coordinating the actions of various ingredients in a prescription, for making medicine.
The leukemic Chinese medicine composition for the treatment of of the present invention has effect that heat-clearing and toxic substances removing, QI invigorating are established the yang function, and it can be eliminating evil, again can righting, thus not eliminating evil just wound, heresy is not loved in righting, and the effect of collaborative performance right supporting anticancer, therefore obtain good curative effect.
The specific embodiment
Below the invention will be further described for the description by the specific embodiment, but this is not limitation of the present invention, those skilled in the art are according to basic thought of the present invention, can make various modifications or improvement, but only otherwise depart from basic thought of the present invention, all within the scope of the present invention.
The preparation of embodiment 1 decoction of the present invention
Get 1 gram of 8 grams of well limit grass, 6 grams of Herba Cayatiae Japonicaes, 10 grams of Radix Seu Caulis Mucunae Sempervirentis, 9 grams of Tucrium Pilosums, 8 grams of Cortex Magnoliae Officinalis, 6 grams of Herba Taraxacis, 7 grams of Semen Coiciss, 6 grams of Cortex Cinnamomis, 5 grams of Radix Bauhiniae Hupehanaes, 6 grams of Fructus Schisandrae Chinensis, 6 grams of Ramulus Cinnamomi, 4 grams of Flos Inulaes, 3 grams of Radix Curcumaes, 4 grams of Pericarpium Citri Reticulataes, 3 grams of the Cortexs Eucommiae, 2 grams of Fructus Corni, 2 grams of Caulis Polygoni Multiflori, 3 grams of Exocarpium Benincasaes, 2 grams of Herba Leonuris, 1 gram of Rhizoma Acori Graminei, 2 grams of Radix Achyranthis Bidentataes and Herba Plantaginis, add 2 liters, water, under the condition refluxing, heat 5 hours, filter, collect filtrate and be cooled to room temperature.
Experimental example
Physical data
60 routine leukaemics, wherein male 30 examples, female's 30 examples; Acute nonlymphocytic leukemia 37 examples, acute lymphoblastic leukemia (ALL) 23 examples; Year mean age (42.1 ± 11.8).
Diagnostic criteria
Western medicine diagnose standard is with reference to " diagnosis of hematological diseases and criterion of therapeutical effect " (2 editions) of Zhang Zhinan chief editor." the new Chinese medicine guideline of clinical investigations " and " practical traditional Chinese medical science haematol " that Syndrome Differentiation of Traditional Chinese Medicine canonical reference " Chinese Internal Medicine " and Ministry of Public Health are promulgated formulated, distinguish as type of deficiency of both QI and YIN: lustreless complexion, dizzy weak, spontaneous sweating, time have a low grade fever, dysphoria with feverish sensation in the chest palms and soles, palpitation and insomnia, pale tongue, fat have tooth to print, white and thin fur or BOHUANG, thready and rapid pulse or thin and delicate.
Inclusive criteria
1. meet Western medicine diagnose standard person.2. the Chinese medical discrimination person that belongs to type of deficiency of both QI and YIN is at least assert by two above Chinese physicians of intermediate title when dialectical simultaneously.3. adhere to using this programme therapist.
Treat every day with the decoction of preparing in embodiment, oral 1 time of every day, each 100 milliliters, treats 90 days.
Observation index and therapeutic evaluation
The standard of curative effect evaluation is divided into and alleviates CR, partial rcsponse PR completely, do not alleviate NR with reference to Zhang Zhinan chief editor " diagnosis of hematological diseases and criterion of therapeutical effect " (2 editions).Observation index is that chemotherapeutic period is had a blood test weekly conventional 2 times, finishes the course for the treatment of 14 days and does bone marrow cytomorphologic examination when clinical hemogram reaches alleviation standard; Before and after treatment, do the inspections such as hepatic and renal function.Total effective rate=(CR+PR)/total number of cases × 100%.
Find through treatment, in 60 routine patients, alleviate 46 examples completely, partial rcsponse 11 examples, do not alleviate 3 examples, total effective rate 95%.
Model case
1. Hu, 43 years old, man, workman, through examination in hospital, thrombocytopenia, leukocyte be higher, through being diagnosed as leukemia, at hospital's expectant treatment such as transfuse blood.Treat every day with the decoction of preparing in embodiment, oral 1 time of every day, each 100 milliliters, treats 90 days.Through examination in hospital, indices is all within normal range, and wherein leukocyte reverts to 5.8x10
9/ L.
2. Zhang, 48 years old, man, was diagnosed as leukemia through hospital, heating, hemorrhage, osteodynia, dizziness headache, myasthenia of limbs, dry mouth and throat.Treat every day with the decoction of preparing in embodiment, oral 1 time of every day, each 100 milliliters, treats 90 days.Through examination in hospital, every hemocyte index is recovered normally substantially, and above-mentioned symptom disappears, and wherein leukocyte reverts to 6.3x10
9/ L.
High certain, 50 years old, female, was diagnosed as acute leukemia through hospital, with ecchymosis, osteodynia, complexion as ash, dizziness headache, spiritlessness and weakness, soreness of the waist and knees.Treat every day with the decoction of preparing in embodiment, oral 1 time of every day, each 100 milliliters, treats 90 days.Through examination in hospital, above-mentioned symptom disappears, and every hemocyte index is recovered normally substantially, and wherein leukocyte reverts to 4.6x10
9/ L.
Claims (6)
1. the leukemic Chinese medicine composition for the treatment of, it is characterized in that, it is to be made up by weight of following bulk drugs: well limit grass 1-10 part, Herba Cayatiae Japonicae 1-10 part, Radix Seu Caulis Mucunae Sempervirentis 1-10 part, Tucrium Pilosum 1-10 part, Cortex Magnoliae Officinalis 1-10 part, Herba Taraxaci 1-10 part, Semen Coicis 1-10 part, Cortex Cinnamomi 1-10 part, Radix Bauhiniae Hupehanae 1-10 part, Fructus Schisandrae Chinensis 1-10 part, Ramulus Cinnamomi 1-10 part, Flos Inulae 1-10 part, Radix Curcumae 1-10 part, Pericarpium Citri Reticulatae 1-10 part, Cortex Eucommiae 1-10 part, Fructus Corni 1-10 part, Caulis Polygoni Multiflori 1-10 part, Exocarpium Benincasae 1-10 part, Herba Leonuri 1-10 part, Rhizoma Acori Graminei 1-10 part, Radix Achyranthis Bidentatae 1-10 part and Herba Plantaginis 1-10 part.
2. the leukemic Chinese medicine composition for the treatment of according to claim 1, it is characterized in that, it is to be made up by weight of following bulk drugs: 1 part of 8 parts of well limit grass, 6 parts of Herba Cayatiae Japonicaes, 10 parts of Radix Seu Caulis Mucunae Sempervirentis, 9 parts of Tucrium Pilosums, 8 parts of Cortex Magnoliae Officinalis, 6 parts of Herba Taraxacis, 7 parts of Semen Coiciss, 6 parts of Cortex Cinnamomis, 5 parts of Radix Bauhiniae Hupehanaes, 6 parts of Fructus Schisandrae Chinensis, 6 parts of Ramulus Cinnamomi, 4 parts of Flos Inulaes, 3 parts of Radix Curcumaes, 4 parts of Pericarpium Citri Reticulataes, 3 parts of the Cortexs Eucommiae, 2 parts of Fructus Corni, 2 parts of Caulis Polygoni Multiflori, 3 parts of Exocarpium Benincasaes, 2 parts of Herba Leonuris, 1 part of Rhizoma Acori Graminei, 2 parts of Radix Achyranthis Bidentataes and Herba Plantaginis.
3. the leukemic Chinese medicine composition for the treatment of according to claim 1, is characterized in that, described Chinese medicine composition can be tablet, dispersible tablet, buccal tablet, instant, disintegrating tablet, capsule, powder or decoction.
4. treat the preparation method of leukemic Chinese medicine composition for one kind, the method comprises the following steps: to get Jing Biancao, Herba Cayatiae Japonicae, Radix Seu Caulis Mucunae Sempervirentis, Tucrium Pilosum, Cortex Magnoliae Officinalis, Herba Taraxaci, Semen Coicis, Cortex Cinnamomi, Radix Bauhiniae Hupehanae, Fructus Schisandrae Chinensis, Ramulus Cinnamomi, Flos Inulae, Radix Curcumae, Pericarpium Citri Reticulatae, the Cortex Eucommiae, Fructus Corni, Caulis Polygoni Multiflori, Exocarpium Benincasae, Herba Leonuri, Rhizoma Acori Graminei, Radix Achyranthis Bidentatae and Herba Plantaginis, add 2 liters, water, under the condition refluxing, heat 5 hours, filter, collect filtrate and be cooled to room temperature.
5. the application of Chinese medicine composition in the leukemic medicine of preparation treatment, it is characterized in that, described Chinese medicine composition is to be made up by weight of following bulk drugs: well limit grass 1-10 part, Herba Cayatiae Japonicae 1-10 part, Radix Seu Caulis Mucunae Sempervirentis 1-10 part, Tucrium Pilosum 1-10 part, Cortex Magnoliae Officinalis 1-10 part, Herba Taraxaci 1-10 part, Semen Coicis 1-10 part, Cortex Cinnamomi 1-10 part, Radix Bauhiniae Hupehanae 1-10 part, Fructus Schisandrae Chinensis 1-10 part, Ramulus Cinnamomi 1-10 part, Flos Inulae 1-10 part, Radix Curcumae 1-10 part, Pericarpium Citri Reticulatae 1-10 part, Cortex Eucommiae 1-10 part, Fructus Corni 1-10 part, Caulis Polygoni Multiflori 1-10 part, Exocarpium Benincasae 1-10 part, Herba Leonuri 1-10 part, Rhizoma Acori Graminei 1-10 part, Radix Achyranthis Bidentatae 1-10 part and Herba Plantaginis 1-10 part.
6. application according to claim 5, it is characterized in that, described Chinese medicine composition is to be made up by weight of following bulk drugs: 1 part of 8 parts of well limit grass, 6 parts of Herba Cayatiae Japonicaes, 10 parts of Radix Seu Caulis Mucunae Sempervirentis, 9 parts of Tucrium Pilosums, 8 parts of Cortex Magnoliae Officinalis, 6 parts of Herba Taraxacis, 7 parts of Semen Coiciss, 6 parts of Cortex Cinnamomis, 5 parts of Radix Bauhiniae Hupehanaes, 6 parts of Fructus Schisandrae Chinensis, 6 parts of Ramulus Cinnamomi, 4 parts of Flos Inulaes, 3 parts of Radix Curcumaes, 4 parts of Pericarpium Citri Reticulataes, 3 parts of the Cortexs Eucommiae, 2 parts of Fructus Corni, 2 parts of Caulis Polygoni Multiflori, 3 parts of Exocarpium Benincasaes, 2 parts of Herba Leonuris, 1 part of Rhizoma Acori Graminei, 2 parts of Radix Achyranthis Bidentataes and Herba Plantaginis.
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| CN101693074A (en) * | 2009-10-01 | 2010-04-14 | 冯子政 | Medicament for treating nephropathy |
| CN102631518A (en) * | 2012-04-01 | 2012-08-15 | 湖南创新中医药研究有限公司 | New medicament for treating leukemia |
| CN103110903A (en) * | 2013-03-08 | 2013-05-22 | 薛士成 | Traditional Chinese medicine composition for treating leukemia |
| CN103520324A (en) * | 2013-10-25 | 2014-01-22 | 范银锁 | Traditional Chinese medicine composition for treating leukemia |
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2014
- 2014-03-28 CN CN201410121240.7A patent/CN103845696A/en active Pending
Patent Citations (6)
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|---|---|---|---|---|
| CN1071582A (en) * | 1991-10-12 | 1993-05-05 | 龙孟麟 | Aplastic anemia is converted into leukemia |
| CN1090494C (en) * | 1991-10-12 | 2002-09-11 | 龙孟麟 | Leukemia converted from aplastic anemia |
| CN101693074A (en) * | 2009-10-01 | 2010-04-14 | 冯子政 | Medicament for treating nephropathy |
| CN102631518A (en) * | 2012-04-01 | 2012-08-15 | 湖南创新中医药研究有限公司 | New medicament for treating leukemia |
| CN103110903A (en) * | 2013-03-08 | 2013-05-22 | 薛士成 | Traditional Chinese medicine composition for treating leukemia |
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