CN103845069A - Radiotherapeutic system integrated with PET-CT (positron emission tomography-computer tomography) function - Google Patents
Radiotherapeutic system integrated with PET-CT (positron emission tomography-computer tomography) function Download PDFInfo
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- CN103845069A CN103845069A CN201210495164.7A CN201210495164A CN103845069A CN 103845069 A CN103845069 A CN 103845069A CN 201210495164 A CN201210495164 A CN 201210495164A CN 103845069 A CN103845069 A CN 103845069A
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Abstract
The invention provides a radiotherapeutic system integrated with a PET-CT function and belongs to the field of medical instruments. The radiotherapeutic system integrated with the PET-CT function comprises a frame, a cylindrical accelerator device which is arranged on the frame and used for radiation treatment on patients, and a cylindrical PET-CT imaging device which is arranged on the frame and used for obtaining images of the patients, wherein the central line of the treatment hole of the cylindrical accelerator device coincides with that of the treatment hole of the cylindrical PET-CT imaging device. The radiotherapeutic system integrated with the PET-CT function can achieve accurate radiation positions and precise dose feeding of the tumor radiotherapeutic technology and accurate three-dimensional biological conformality intensity modulated radiation therapy.
Description
Technical field
The present invention relates to medical instruments field, refer to especially a kind of radiotherapy system of the PET-CT of fusion function.
Background technology
At present, the radiation therapy technology of tumor has entered the accurate epoch, accurately irradiation position and accurately dosage give, therefore produced the image guided radiation therapy technology IGRT(Image-Guided Radio Therapy of current field of radiation therapy extensive use) and Intensity Modulation Radiated Therapy (IMRT) technology IMRT(Intensity-Modulated Radio Therapy), the application of these two radiotherapy new techniques has improved radiotherapy level greatly, and therefore they are called as the revolutionary variation of 20th century radiation therapy technology.
But from the decades of clinical application practice from statistical significance interpretation of result, this technical revolutionary variation, does not bring oncotherapy effect or local control rate aspect to produce revolutionary variation or raising.This is mainly because above-mentioned two technology are the accurate distributions based on the accurate physical location of tumor and physical dosage, do not consider characteristic and the difference of aspect biology (metabolism, weary oxygen, radiation sensitive) of tumor patient individuality.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of radiotherapy system of the PET-CT of fusion function, can realize the irradiation position accurately of the radiation therapy technology to tumor and accurately dosage give, and realize accurate three-dimensional Biologically conformal intensity modulated radiation therapy.
For solving the problems of the technologies described above, embodiments of the invention provide technical scheme as follows:
On the one hand, provide a kind of radiotherapy system of the PET-CT of fusion function, comprising:
Frame;
Be arranged in described frame, for generation of electron beam, patient carried out to radiocurable drum type brake accelerator installation;
Be arranged in described frame, for obtaining drum type brake positron emission computerized tomography-computed tomography PET-CT imaging device of patient's image;
Wherein, the treatment centerline hole of described drum type brake accelerator installation overlaps with the treatment centerline hole of described drum type brake PET-CT imaging device.
Further, in such scheme, described drum type brake PET-CT imaging device stack is arranged on described drum type brake accelerator installation.
Further, in such scheme, described drum type brake accelerator installation comprises the accelerator body that can produce high-power electron beam.
Further, in such scheme, described accelerator body is the linear accelerator of produce power at the above electron beam of 45M electron volts.
Further, in such scheme, described drum type brake accelerator installation also comprises:
Be arranged on the treatment head towards described treatment hole being connected in described frame, with described accelerator body.
Further, in such scheme, described drum type brake accelerator installation also comprises:
Be arranged on IMRT or IGRT flat panel detector in described frame.
Further, in such scheme, described drum type brake accelerator installation also comprises:
Be arranged on the microwave generator in described frame.
Embodiments of the invention have following beneficial effect:
In such scheme, radiotherapy system includes accelerator installation and PET-CT imaging device, when the x-ray bombardment patient of accelerator transmitting, in killing tumor cell, oxygen 16 that can excite tissue, carbon 12 produces positron emission core oxygen 15, carbon 11 etc., now can adopt PET-CT imaging device to carry out scanning imaging, determine the position of x-ray bombardment and the dose distribution of irradiation, realized treatment and living body biological checking and biological effect analysis carries out simultaneously, also can realize the radiotherapy of image guiding biology, thereby truly realize accurate three-dimensional Biologically conformal intensity modulated radiation therapy and checking.
Brief description of the drawings
Fig. 1 is the front schematic view of the radiotherapy system of the embodiment of the present invention;
Fig. 2 is the schematic side view of the radiotherapy system of the embodiment of the present invention.
Reference numeral
1 accelerator installation
2PET-CT device
3 treatment holes
4 accelerator bodies
5 treatment heads
6 microwave generators
7 is patient bed
Detailed description of the invention
For technical problem, technical scheme and advantage that embodiments of the invention will be solved are clearer, be described in detail below in conjunction with the accompanying drawings and the specific embodiments.
These two radiation therapy technologies of existing IGRT and IMRT are the accurate distributions based on the accurate physical location of tumor and physical dosage, do not consider characteristic and the difference of aspect biology (metabolism, weary oxygen, radiation sensitive) of tumor patient individuality.If can be on the basis of IGRT and these two technology of IMRT from position that angle collation is penetrated and dosage is verified and studying and evaluating aspect postradiation biological effect biology of tumor patient individuality, i.e. (the Biological target volume from biological target area, and Biologically conformal Intensity Modulation Radiated Therapy (IMRT) (Biological IMRT BTV), Bio-IMRT) radiotherapy of aspect research tumor, will make the radiation therapy technology of tumor attain a new height.
PET-CT(Positron Emission Computed Tomography-computed tomography, positron emission computerized tomography-computed tomography) CT and PET are combined together, provide the precise anatomical of focus to locate by CT, and PET provides function and metabolism equimolecular information that focus is detailed, there is the features such as sensitive, accurate, special and registration, a video picture can obtain the faultage image in the each orientation of whole body, can open-and-shut understanding whole body integral status, the object that reaches early discovery focus and diagnose the illness.
Embodiments of the invention are for the accurate distribution of only considering in prior art based on the accurate physical location of tumor and physical dosage, can not effectively improve the problem of oncotherapy effect, a kind of radiotherapy system of the PET-CT of fusion function is provided, can realize the irradiation position accurately of the radiation therapy technology to tumor and accurately dosage give, and realize accurate three-dimensional Biologically conformal intensity modulated radiation therapy.
As shown in Figure 1, the radiotherapy system of the fusion PET-CT function of the embodiment of the present invention comprises:
Frame;
Be arranged in frame, for generation of electron beam, patient carried out to radiocurable drum type brake accelerator installation 1;
Be arranged in frame, for obtaining drum type brake positron emission computerized tomography-computed tomography PET-CT imaging device 2 of patient's image;
Wherein, the treatment centerline hole of drum type brake accelerator installation 1 overlaps with the treatment centerline hole of drum type brake PET-CT imaging device 2.
Further, as shown in Figure 2,2 stacks of drum type brake PET-CT imaging device are arranged on drum type brake accelerator installation 1, be laminated in the frame of radiotherapy system, radiotherapy system of the present invention only has a treatment hole, and drum type brake accelerator installation 1 and drum type brake PET-CT imaging device 2 share a treatment hole 3.
Further, as shown in Figure 1, drum type brake accelerator installation 1 comprises accelerator body 4, accelerator body 4 can be for producing the accelerator of high-power electron beam, particularly, accelerator body 4 can be the linear accelerator of produce power at the above electron beam of 45M electron volts, i.e. LA45 high energy acclerator.
Further, as shown in Figure 1, drum type brake accelerator installation 1 also comprises and is arranged on the treatment 5 towards treatment hole 3 being connected in frame, with accelerator body 4.
Further, as shown in Figure 1, drum type brake accelerator installation 1 also comprises the microwave generator 6 being arranged in frame.
Further, in radiotherapy system of the present invention, IMRT or IGRT flat panel detector can also be set in frame, make the radiotherapy system can integrated IMRT or IGRT function.
Radiotherapy system of the present invention includes accelerator installation and PET-CT imaging device, when the x-ray bombardment patient of accelerator transmitting, in killing tumor cell, oxygen 16 that can excite tissue, carbon 12 produces positron emission core oxygen 15, carbon 11 etc., now can adopt PET-CT imaging device to carry out scanning imaging, determine the position of x-ray bombardment and the dose distribution of irradiation, realized treatment and living body biological checking and biological effect analysis carries out simultaneously, also can realize the radiotherapy of image guiding biology, thereby truly realize accurate three-dimensional Biologically conformal intensity modulated radiation therapy and checking.
Taking accelerator as LA45 high energy acclerator is as example, the work process of radiotherapy system of the present invention is described in detail below:
As shown in Figure 2, in technical scheme of the present invention, the as a whole structure of PET-CT imaging device 2, itself and drum type brake accelerator installation 1 next-door neighbour arrange, be laminated in the frame of radiotherapy system, drum type brake accelerator installation 1 and drum type brake PET-CT imaging device 2 share a treatment hole 3.In the time adopting radiotherapy system of the present invention to treat patient's (being tumour patient), patient lies on patient bed 7, enters treatment hole 3, and the 45MV sigmatron of high energy acclerator transmitting irradiates tumour patient, in killing tumor cell, the oxygen 16(of excite tissue
16o), carbon 12(
12c) produce positron emission core oxygen 15(
15o), carbon 11(
11c) etc., patient carries out scanning imaging with PET-CT imaging device immediately after irradiation or treatment, determine the position of x-ray bombardment and the dose distribution of irradiation, realized treatment and live body (in-vivo) biometric authentication and biological effect analysis carries out simultaneously, also the radiotherapy (Bio-IGRT) of image guiding biology be can realize, thereby accurate three-dimensional Biologically conformal Intensity Modulation Radiated Therapy (IMRT) (Bio-IMRT) and checking truly realized.
Radiotherapy system of the present invention adopts LA45 high energy acclerator 45MV sigmatron and flat panel detector combination, carry out image acquisition and processing, exploitation 2 dimensions, 3 d image reconstruction, registration, fusion, not only realize the technology of IGRT and CBCT, and realize the fusion of the multi-modality images such as CT, PET, thereby make the function of equipment more perfect and powerful; Adopt this radiotherapy system, the X ray of the 45MV energy producing, can excite porphyrin targeted drug, produces oxygen-derived free radicals, thereby irreversiblely kill cancerous cell, leukaemia and vascular plaque foam cell, thereby extremely effectively treat cancer, leukemia and cardiovascular and cerebrovascular disease.And carry out scanning imaging by PET-CT imaging device, determine the position of x-ray bombardment and the dose distribution of irradiation, can realize (the Biological target volume from biological target area, BTV) and tumor to the biological effect aspect of sigmatron to tumor implement Biologically conformal Intensity Modulation Radiated Therapy (IMRT) (Biological IMRT, Bio-IMRT).
The above is the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, do not departing under the prerequisite of principle of the present invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (7)
1. a radiotherapy system that merges PET-CT function, is characterized in that, comprising:
Frame;
Be arranged in described frame, for generation of electron beam, patient carried out to radiocurable drum type brake accelerator installation;
Be arranged in described frame, for obtaining drum type brake positron emission computerized tomography-computed tomography PET-CT imaging device of patient's image;
Wherein, the treatment centerline hole of described drum type brake accelerator installation overlaps with the treatment centerline hole of described drum type brake PET-CT imaging device.
2. radiotherapy system according to claim 1, is characterized in that, described drum type brake PET-CT imaging device stack is arranged on described drum type brake accelerator installation.
3. radiotherapy system according to claim 1, is characterized in that, described drum type brake accelerator installation comprises the accelerator body that can produce high-power electron beam.
4. radiotherapy system according to claim 3, is characterized in that, described accelerator body is the linear accelerator of produce power at the above electron beam of 45M electron volts.
5. radiotherapy system according to claim 3, is characterized in that, described drum type brake accelerator installation also comprises:
Be arranged on the treatment head towards described treatment hole being connected in described frame, with described accelerator body.
6. radiotherapy system according to claim 5, is characterized in that, described drum type brake accelerator installation also comprises:
Be arranged on IMRT or IGRT flat panel detector in described frame.
7. radiotherapy system according to claim 5, is characterized in that, described drum type brake accelerator installation also comprises:
Be arranged on the microwave generator in described frame.
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| CN201210495164.7A CN103845069A (en) | 2012-11-28 | 2012-11-28 | Radiotherapeutic system integrated with PET-CT (positron emission tomography-computer tomography) function |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106139417A (en) * | 2016-07-26 | 2016-11-23 | 清华大学 | Double drum type many supports Multiple laser system controls CT linear accelerator |
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