CN103844271A - Nutritive combination agent capable of preventing and treating dementia - Google Patents
Nutritive combination agent capable of preventing and treating dementia Download PDFInfo
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- CN103844271A CN103844271A CN201210516900.2A CN201210516900A CN103844271A CN 103844271 A CN103844271 A CN 103844271A CN 201210516900 A CN201210516900 A CN 201210516900A CN 103844271 A CN103844271 A CN 103844271A
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- 206010012289 Dementia Diseases 0.000 title claims abstract description 20
- 230000000050 nutritive effect Effects 0.000 title abstract description 5
- 210000004958 brain cell Anatomy 0.000 claims abstract description 15
- 239000000419 plant extract Substances 0.000 claims abstract description 13
- 229930003231 vitamin Natural products 0.000 claims abstract description 13
- 235000013343 vitamin Nutrition 0.000 claims abstract description 13
- 239000011782 vitamin Substances 0.000 claims abstract description 13
- 229940088594 vitamin Drugs 0.000 claims abstract description 13
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 11
- 235000016709 nutrition Nutrition 0.000 claims abstract description 9
- 230000035764 nutrition Effects 0.000 claims abstract description 7
- 239000000843 powder Substances 0.000 claims abstract description 7
- 210000005013 brain tissue Anatomy 0.000 claims abstract description 6
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- 239000003053 toxin Substances 0.000 claims abstract description 3
- 231100000765 toxin Toxicity 0.000 claims abstract description 3
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 12
- 235000015097 nutrients Nutrition 0.000 claims description 9
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- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 8
- 235000021388 linseed oil Nutrition 0.000 claims description 7
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- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 4
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- VRKKUDZYIGLTIC-UHFFFAOYSA-N 2-phenylchromen-4-one silver Chemical compound [Ag].O1C(=CC(=O)C2=CC=CC=C12)C1=CC=CC=C1 VRKKUDZYIGLTIC-UHFFFAOYSA-N 0.000 description 1
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- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
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- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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Abstract
The invention belongs to the field of nutritional supplement agent type nutritive function food or medicine-food dual purposes, and relates to a nutritive combination agent capable of preventing and treating dementia. The nutritive combination agent capable of preventing and treating dementia is characterized by comprising powder of multiple plant extracts, an oiling agent and vitamins, is capable of providing essential nutrition and other substances for brain cells, promoting brain cells to absorb nutrition and exclude toxins very well, ensuring that brain cells and brain tissues accelerate own ability of regulation and control, and preventing symptoms such as memory loss and dementia and has a treatment effect for patients with senile dementia and parkinson disease and certain moderate and severe patients.
Description
Technical field
The present invention is nutraceutical or medicine field, and the nutrient combination agent that relates to the symptoms such as prevention, treatment, rehabilitation memory loss, mistake intelligence, senile dementia, Alzheimer's disease is to have unique, Xin Ka-Wing technical characterictic;
Technical background
China has entered aging society; According to statistics, existing 6,000,000 old dementia patients of China, have become the 4th " dead killer " being only second to heart disease, cancer, apoplexy.Annual newly-increased 300,000 dull-witted sufferers, all cause very big burden to society, family, patient now.
At present, dementia is one of disease of the most normal See in elderly population, is the common disease in Lao year people Jian Kang Long longevity of harm, lacks very much good medicine now and improves the nutriment of symptom; Its main cause is that cause of disease complexity, kind are tired many, and some cause of disease finds Zhi Jin Hai No, just cannot treat and rehabilitation; Therefore, Alzheimer's disease (senile dementia) is the problem that current social is extremely urgent, and research and development related drugs and nutriment are the task of top priority.
Summary of the invention
The object of the invention is to study a kind of prevention, treatment, rehabilitation, to lose memory, lose the nutrient combination agent of the symptoms such as intelligence, senile dementia Alzheimer's disease be the deficiency that makes up current medicine, treatment technology; Especially the deficiency of preventive medicine aspect;
Senile dementia is divided into according to its cause of disease: brain degenerative disease causes that dementia is that Alzheimer's disease (being called for short AD), the cerebrovascular cause the three major types such as dementia (being called for short VaD), Mixed dementia (being called for short MixD), also has the dementia of other Different types of etiopathogenises;
Medical circle generally acknowledges that dementia pathogenesis mainly contains two kinds at present: 1, because the protein ingredient that extremely causes of amyloid lipoprotein spills cell membrane, cause neuron Xian Wei Wrapping knot and cell death; 2, relevant with the gene of apo E (APO-E4), APO-E4, when increasing the function that can resist APO-E2 or APO-E3, reduces nerve cell membrane stability, causes the fine dimension of neuron Wrapping knot and cell death;
Research and development theory of the present invention is thought:
1, because elderly brain cell can not absorb or the less absorption polyphenoils, Long phase is encroached on by free radical toxin, immunologic function is declined, thereby the protein ingredient that extremely causes of generation amyloid lipoprotein spill cell membrane, causes neuron Xian Wei Wrapping knot and cell death; The needed polyphenoils of brain cell, the present invention finds a kind of title brain flavones (polyphenoils that a kind of brain cell needs, hereinafter to be referred as brain ketone), and it is that one exists flavones in maple seed, in test application, is better than other plant flavone;
2, brain cell absorbs less than desired nutritional, especially not fertile in body is tetracosenoic acid (claiming again shark Fish acid) to the very important nervonic acid of brain cell, will in brain tissue, produce APO-E4 increases, nerve cell membrane stability is reduced, cause the fine dimension of neuron Wrapping knot and cell death;
3, brain tissue blood supply insufficiency is that brain cell absorbs less than the Important cause of disease of desired nutritional, some patient body absorption function is fair, dietary structure, appetite all can, but because abnormal (cause of disease is more) appears in brain blood supply, also can cause dementia to occur;
4, in practice, find that outside nutrition eliminating minute element that brain cell needs, wherein crucial nutrition is the not absorption of Eat and aliphatic acid and Eat and the corresponding balance of aliphatic acid, possesses Eat and fatty acid nutritive brain cell and the brain tissue of sufficient Enough with treadle-operated tilt hammer for hulling rice;
5, select brain cell, organize needed nutrient to modulate maintenance;
For this reason, the present invention has researched and developed a kind of nutrient combination agent that prevents and treats dementia, is applicable to prevention and treatment mild dementia and indivedual moderate dementia disease patient;
Measure of the present invention:
1, select maple seed extract, can be pulvis or finish, it contains rare nervonic acid is tetracosenoic acid, and it has nerve fibre reparation and dredging function, is generally acknowledged by world many countries, and various countries are further research and development;
2, it is considered herein that maple flavones is one of brain ketone, and to select Tea Polyphenols, Silver flavone be antioxidant and blood-activating formula, reach the object of removing free radical and increasing the circulation of Strong brain blood;
3, select the not grease of Eat and aliphatic acid and Eat and aliphatic acid to come balance and supplementary brain cell nutrition;
4, select vitamin C and vitamin E further to promote to remove free radical, trophic nerve system;
5, select lecithin and the linseed oil of nutrition brain tissue, especially linseed oil is containing leukotrienes, and its metabolite can impel low-density lipoprotein (LDL) to transform and raise to high density lipoprotein level (HDL), thereby reach reducing blood lipid, the object of atherosclerosis; Leukotrienes can impel free radical to decline, and is again the indispensable aliphatic acid of brain, for brain provides large energy, thereby has strengthened brain intelligence, brain is normally played a role and just can keep fit;
A kind of nutrient combination agent that prevents and treats dementia of the present invention, completes by following method:
The nutrient combination agent of a kind of prevention, treatment dementia is made up of plant extracts finish, pulvis and vitamin; Described raw material, is by weight proportion: plant extracts finish accounts for 9799%, and pulvis and vitamin account for 1-3%;
Wherein, plant extracts finish is
(1), maple seed oil 6---10%
(2), linseed oil 10---50%
(3), olive oil 1---33%
(4), lecithin oil 1-5%
(5), coconut oil 1---79%
Plant extract medicinal powder and vitamin are:
(6), plant extract medicinal powder 0.5-2.6% Tea Polyphenols and ginkgo yellow acid were by 2: 1 compositions;
(7), vitamin 0.4--0.5% vitamin C and vitamin E were by 9: 1 compositions;
Production craft step of the present invention is:
1, will meet food grade finish and pulvis (by 200 orders), raw material is weighed by weight;
2, olive oil or linseed oil are heated to 60 degrees Celsius, various pulvis are added to broad state while stirring, be incubated after two hours, filter 200 mesh sieves, remove impurity;
3, slow other various finishes Slow is injected to insulation oil and stir;
4,30,450,900g is advisable the filling one-tenth finished product of normal temperature to be down to, every bottle:;
5, root Ju conditions of patients treadle-operated tilt hammer for hulling rice is determined dose;
The present invention is further described, specific embodiment one, but the present invention is not only limited to this embodiment:
1, select to meet food grade finish and be: 98 kilograms
Wherein:
(1), 9.0 kilograms of maple seed oil
(2), 50 kilograms of linseed oil
(3), 18 kilograms, olive oil
(4), 3.0 kilograms of lecithin oil
(5), 18 kilograms of coconut oil
2, select plant extract medicinal powder and vitamin (all by 200 orders) to be: 2.0 kilograms
Wherein:
(1), 1.0 kilograms of plant extracts Tea Polyphenols
0.5 kilogram of GINKGO BILOBA EXTRACT
(2), 0.45 kilogram of vitamin vitamin C
0.05 kilogram of vitamin E
Production craft step of the present invention is:
1, will meet food grade finish and pulvis, raw material is weighed by weight;
2, olive oil or linseed oil are heated to 60 degrees Celsius, various pulvis are added to broad state while stirring, be incubated after two hours, filter 200 mesh sieves, remove impurity;
3, slow other various finishes Slow is injected to insulation oil and stir;
4, normal temperature to be down to is below 28 degrees Celsius, filling one-tenth finished product, and every bottle 30,450,900g are advisable;
5, determine dose according to conditions of patients treadle-operated tilt hammer for hulling rice.
Claims (3)
1. the nutrient combination agent of prevention, treatment dementia is to provide a brain cell nutrition, improves the trophic function food (belonging to medicine-food two-purpose product) of toxin in function of brain cell and discharge brain tissue;
It is characterized in that: the nutrient combination agent of a kind of prevention, treatment dementia is made up of plant extracts finish and pulvis and vitamin;
Described raw material is: finish accounts for 9799% that pulvis and vitamin account for 1--3% by weight proportion;
Wherein, finish is
(1), maple seed oil 6---10%
(2), linseed oil 10---50%
(3), olive oil 1---33%
(4), lecithin oil 1-5%
(5), coconut oil 1---79%
Plant extract medicinal powder and vitamin, by 200 orders be:
(6), plant extract medicinal powder 0.5-2.6%;
(7), vitamin 0.4--0.5%.
2. according to right 1 requirement, described plant extract medicinal powder is made up of by 2: 1 Tea Polyphenols and GINKGO BILOBA EXTRACT;
Described vitamin is made up of by 9: 1 vitamin C and vitamin E.
3. according to right 1 requirement, described plant extracts finish, pulvis and vitamin all reach the regulation of food-grade and food additives.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201210516900.2A CN103844271A (en) | 2012-12-06 | 2012-12-06 | Nutritive combination agent capable of preventing and treating dementia |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210516900.2A CN103844271A (en) | 2012-12-06 | 2012-12-06 | Nutritive combination agent capable of preventing and treating dementia |
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| CN201210516900.2A Pending CN103844271A (en) | 2012-12-06 | 2012-12-06 | Nutritive combination agent capable of preventing and treating dementia |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104258241A (en) * | 2014-09-26 | 2015-01-07 | 洛阳华以生物工程有限公司 | Health product for preventing and treating senile dementia |
| CN105533726A (en) * | 2015-12-09 | 2016-05-04 | 南京贝杉国际贸易有限公司 | Formula food supplementing omega-3 fatty acids and preventing Alzheimer's disease and preparation method thereof |
| CN106389740A (en) * | 2016-09-13 | 2017-02-15 | 王全峰 | Composition for preventing and/or delaying old people with mild cognitive impairment and use method thereof |
| CN106420796A (en) * | 2016-12-26 | 2017-02-22 | 哈尔滨工业大学（威海） | Composition for preventing or treating Alzheimer's disease |
| WO2017113775A1 (en) * | 2015-12-29 | 2017-07-06 | 浙江旭晨医药科技有限公司 | Application of triglyceride compound for use in preparing medicine for treating neurodegenerative diseases |
| CN109744534A (en) * | 2018-12-13 | 2019-05-14 | 齐齐哈尔医学院附属第二医院 | Dedicated clinical nutrition formula of Parkinsonian and preparation method thereof |
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| CN1421208A (en) * | 2001-11-22 | 2003-06-04 | 中国科学院地理科学与资源研究所 | Compound prepn containing alpha-linolic acid, lecithin and ginkgetin |
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| CN1421208A (en) * | 2001-11-22 | 2003-06-04 | 中国科学院地理科学与资源研究所 | Compound prepn containing alpha-linolic acid, lecithin and ginkgetin |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104258241A (en) * | 2014-09-26 | 2015-01-07 | 洛阳华以生物工程有限公司 | Health product for preventing and treating senile dementia |
| CN105533726A (en) * | 2015-12-09 | 2016-05-04 | 南京贝杉国际贸易有限公司 | Formula food supplementing omega-3 fatty acids and preventing Alzheimer's disease and preparation method thereof |
| WO2017113775A1 (en) * | 2015-12-29 | 2017-07-06 | 浙江旭晨医药科技有限公司 | Application of triglyceride compound for use in preparing medicine for treating neurodegenerative diseases |
| CN106389740A (en) * | 2016-09-13 | 2017-02-15 | 王全峰 | Composition for preventing and/or delaying old people with mild cognitive impairment and use method thereof |
| CN106420796A (en) * | 2016-12-26 | 2017-02-22 | 哈尔滨工业大学（威海） | Composition for preventing or treating Alzheimer's disease |
| CN109744534A (en) * | 2018-12-13 | 2019-05-14 | 齐齐哈尔医学院附属第二医院 | Dedicated clinical nutrition formula of Parkinsonian and preparation method thereof |
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Application publication date: 20140611 |