CN103844215A - High-activity and high-content superoxide dismutase (SOD) roxburgh rose composite tablet preparation method - Google Patents
High-activity and high-content superoxide dismutase (SOD) roxburgh rose composite tablet preparation method Download PDFInfo
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- CN103844215A CN103844215A CN201210520478.8A CN201210520478A CN103844215A CN 103844215 A CN103844215 A CN 103844215A CN 201210520478 A CN201210520478 A CN 201210520478A CN 103844215 A CN103844215 A CN 103844215A
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- sod
- superoxide dismutase
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- roxburgh rose
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- 102000019197 Superoxide Dismutase Human genes 0.000 title claims abstract description 47
- 108010012715 Superoxide dismutase Proteins 0.000 title claims abstract description 47
- 230000000694 effects Effects 0.000 title claims abstract description 22
- 239000002131 composite material Substances 0.000 title claims abstract description 9
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 241000220317 Rosa Species 0.000 title abstract 2
- 238000000034 method Methods 0.000 claims abstract description 14
- 238000005469 granulation Methods 0.000 claims abstract description 7
- 230000003179 granulation Effects 0.000 claims abstract description 7
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 238000009501 film coating Methods 0.000 claims abstract description 5
- 239000000463 material Substances 0.000 claims abstract description 5
- 238000000108 ultra-filtration Methods 0.000 claims abstract description 5
- 240000002547 Rosa roxburghii Species 0.000 claims description 18
- 235000000640 Rosa roxburghii Nutrition 0.000 claims description 18
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 6
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 239000006228 supernatant Substances 0.000 claims description 6
- 102000004190 Enzymes Human genes 0.000 claims description 5
- 108090000790 Enzymes Proteins 0.000 claims description 5
- 229940088598 enzyme Drugs 0.000 claims description 5
- 239000007888 film coating Substances 0.000 claims description 4
- 238000000227 grinding Methods 0.000 claims description 4
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 3
- 108010059892 Cellulase Proteins 0.000 claims description 3
- 229920002261 Corn starch Polymers 0.000 claims description 3
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 3
- 229920001353 Dextrin Polymers 0.000 claims description 3
- 239000004375 Dextrin Substances 0.000 claims description 3
- 229930003268 Vitamin C Natural products 0.000 claims description 3
- 229930003427 Vitamin E Natural products 0.000 claims description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 3
- 238000009835 boiling Methods 0.000 claims description 3
- 239000011575 calcium Substances 0.000 claims description 3
- 229910052791 calcium Inorganic materials 0.000 claims description 3
- 235000001465 calcium Nutrition 0.000 claims description 3
- 229940106157 cellulase Drugs 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 3
- 239000008120 corn starch Substances 0.000 claims description 3
- 229940099112 cornstarch Drugs 0.000 claims description 3
- 239000008367 deionised water Substances 0.000 claims description 3
- 229910021641 deionized water Inorganic materials 0.000 claims description 3
- 235000019425 dextrin Nutrition 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 3
- 239000012634 fragment Substances 0.000 claims description 3
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 3
- 229940059442 hemicellulase Drugs 0.000 claims description 3
- 108010002430 hemicellulase Proteins 0.000 claims description 3
- 229910052742 iron Inorganic materials 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 238000004080 punching Methods 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 3
- 235000019154 vitamin C Nutrition 0.000 claims description 3
- 239000011718 vitamin C Substances 0.000 claims description 3
- 235000019165 vitamin E Nutrition 0.000 claims description 3
- 229940046009 vitamin E Drugs 0.000 claims description 3
- 239000011709 vitamin E Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000011701 zinc Substances 0.000 claims description 3
- 229910052725 zinc Inorganic materials 0.000 claims description 3
- 235000016804 zinc Nutrition 0.000 claims description 3
- 238000000465 moulding Methods 0.000 claims description 2
- 238000005516 engineering process Methods 0.000 abstract description 5
- 241000109329 Rosa xanthina Species 0.000 abstract 1
- 235000004789 Rosa xanthina Nutrition 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000004321 preservation Methods 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 238000004537 pulping Methods 0.000 abstract 1
- 230000000717 retained effect Effects 0.000 abstract 1
- 239000010409 thin film Substances 0.000 abstract 1
- 239000000284 extract Substances 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 241000781608 Scolopia zeyheri Species 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 238000000748 compression moulding Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000000383 hazardous chemical Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/01—Instant products; Powders; Flakes; Granules
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention provides a preparation method for a high-activity and high-content superoxide dismutase (SOD) roxburgh rose composite tablet preparation method. Wild roxburgh roses are used as a raw material, and superoxide dismutase (SOD) is extracted by a whole-course low-temperature technology; after making is executed, a thin film coating technology is adopted to avoid air contact, so that the content and the activity of the SOD are retained to the maximum extent; the activity preservation period of the SOD can be prolonged during tablet making. The method comprises the steps of material selection, pulping, enzymolysis, rough filtration, ultrafiltration, granulation and tabletting. The preparation method has the characteristics of simplicity, quickness, high activity, short response time, high content and good effect; the problems of difficulty in storage of the SOD and loss of effective components of a finished product are solved.
Description
Technical field
The invention belongs to biologically active extracts active ingredients and technology of preparing, be specifically related to one taking wild thorn pear fruit as raw material, under low temperature environment, extract the method for superoxide dismutase (SOD) film-making.
Background technology
Superoxide dismutase (SOD) has its special biologically active, and when the pH value of its adaptation is 5～10, PH=8, activity is the highest, and having in environment temperature is the most stable characteristic of biologically active below 60 DEG C time.Traditional process need of producing dries and dries processing, and long because of drying time, and in the time drying, the ultraviolet ray in sunlight can cause superoxide dismutase a large amount of in Rosa roxburghii (SOD) to run off.And in the technique of some improvement, although through pulverizing, thermal shock, the step such as centrifugal, also can be because of there being high temperature link, the problem that causes superoxide dismutase a large amount of in Rosa roxburghii (SOD) to run off.
Summary of the invention
For solving the above-mentioned problems in the prior art, the present invention is under the condition of omnidistance temperature≤55 DEG C of controling environment of preparation, from Single Roxburgh Rose Fruit, extract superoxide dismutase (SOD), and adopt film-coated technique effectively to preserve its high activity content, produce in flakes from superoxide dismutase, all under the relatively low environment temperature of temperature≤55 DEG C, carry out, and take packaging technique in blocks, preserve to greatest extent the activity of a large amount of superoxide dismutases (SOD) in Rosa roxburghii.High activity content superoxide dismutase (SOD) Rosa roxburghii composite sheet after producing, the content of superoxide dismutase (SOD) can reach 20000～90000UG/100G, enzyme activity reaches 500000～2000000IU/100G, there is high activity onset time fast, the characteristic that high-load is effective.
Concrete, the invention provides the preparation method of a kind of high activity content superoxide dismutase (SOD) Rosa roxburghii composite sheet, comprise the following steps:
A, the sodium chloride solution that is 1～2% by concentration by the Single Roxburgh Rose Fruit of selecting clean 2～3 times, then use lower than the deionized water punching of 30 DEG C and soak 48 hours, dry afterwards;
B, the Single Roxburgh Rose Fruit of steps A gained is cut into the PBS that adds 200umol/L after fragment by 10～30L/kg, adjusts pH value in 7～9 scope, then grind, after corase grind, fine grinding, obtain Rosa roxburghii magma;
C, the Rosa roxburghii magma of step B gained is added to enzyme (cellulase, hemicellulase, pectase), after mixing, then to add concentration by 100～200mL/kg be 10～40% calcium chloride solution, leaves standstill and be no less than 3 hours, to precipitate;
D, adopt 5000rpm～10000rpm high speed channel separator to the solution of step C gained carry out 10～20 minutes centrifugal, obtain thick liquid, and leave and take supernatant;
E, the supernatant of step D gained is carried out to ultrafiltration obtain filtrate, carry out essence filter by nanofilter, obtain the translucent concentrated liquid of yellowish-brown;
F, employing low-temperature boiling granulation technique, control temperature≤55 DEG C, add functional raw material (vitamin C or vitamin E or calcium or zinc or iron) taking cornstarch or dextrin as base-material and in 1: 0.1～1: 0.5 ratio, the concentrate of step e gained is carried out to low temperature granulation.
G, after step F makes particle, puddle dolomol remover, and use tablet press machine to carry out moulding compressing tablet;
H, control temperature≤50 DEG C, carry out film coating 3～6 hours, produces out high activity content superoxide dismutase (SOD) Rosa roxburghii composite sheet.
Simple and fast of the present invention, the omnidistance high temperature of avoiding, adopts normal temperature technology, and after producing, adopts film-coated technique, avoids the oxygen in ingress of air, farthest preserves content and the activity of its contained superoxide dismutase (SOD).After measured, the pH value scope that gained superoxide dismutase (SOD) adapts to is that 8 o'clock activity are the highest at 5～10, PH.Whole process using is higher than the environment temperature of 55 DEG C, meets superoxide dismutase (SOD) stable characteristic below 60 DEG C.Making after tablet, adopt film coating and adopt lucifuge packaging, high-load, the high activity of superoxide dismutase (SOD) are preserved to greatest extent, solve superoxide dismutase (SOD) and preserved problem difficult, that finished product active ingredient runs off, do not contain hazardous substance, have no side effect, harmless to human body, animal, and it is fast to have high activity onset time, the characteristic that high-load is effective.
Detailed description of the invention
The specific embodiment of the invention is:
1, select materials: select without worm, without moth, without the fresh Rosa roxburghii going mouldy, remove after impurity, the sodium chloride solution that is first 1～2% by concentration cleans 2～3 times, then soak 48 hours lower than the deionized water punching of 30 DEG C by temperature, dry afterwards;
2, chopping defibrination: gained Rosa roxburghii is cut into the PBS that adds 200umol/L after fragment by 10～30L/kg, adjusts pH value in 7～9 scope, then grind, after corase grind, fine grinding, obtain Rosa roxburghii magma;
3, enzymolysis: add enzyme (cellulase, hemicellulase, pectase) by grinding complete Rosa roxburghii magma, after mixing, then to add concentration by 100～200mL/kg be 10～40% calcium chloride solution, leaves standstill and is no less than 3 hours and precipitates;
4, adopt the high speed channel separator of 5000rpm～10000rpm to obtain thick liquid in centrifugal 10～20 minutes, and leave and take supernatant;
5, ultrafiltration: supernatant is carried out to ultrafiltration and obtain filtrate, carry out essence filter by nanofilter, obtain the translucent concentrated liquid of yellowish-brown;
6, adopt low-temperature boiling granulation technique, control temperature≤55 DEG C, taking cornstarch or dextrin as base-material, and add functional raw material (vitamin C or vitamin E or calcium or zinc or iron) in 1: 0.1～1: 0.5 ratio, gained concentrate is carried out to low temperature granulation;
7, make after particle, puddle dolomol remover, then use tablet press machine compression molding;
8, under the condition of 50 DEG C of constant temperature, carry out film coating 3～6 hours, produce out high activity content superoxide dismutase Rosa roxburghii composite sheet.
Claims (4)
1. high activity content superoxide dismutase (SOD) Rosa roxburghii composite sheet preparation method, is characterized in that, comprises the following steps:
A, the sodium chloride solution that is 1～2% by concentration by the Single Roxburgh Rose Fruit of selecting clean 2～3 times, then use lower than the deionized water punching of 30 DEG C and soak 48 hours, dry afterwards;
B, the Single Roxburgh Rose Fruit of steps A gained is cut into the PBS that adds 200umol/L after fragment by 10～30L/kg, adjusts pH value in 7～9 scope, then grind, after corase grind, fine grinding, obtain Rosa roxburghii magma;
C, the Rosa roxburghii magma of step B gained is added to enzyme, after mixing, then to add concentration by 100～200mL/kg be 10～40% calcium chloride solution, leaves standstill and be no less than 3 hours, to precipitate;
D, adopt 5000rpm～10000rpm high speed channel separator to the solution of step C gained carry out 10～20 minutes centrifugal, obtain thick liquid, and leave and take supernatant;
E, the supernatant of step D gained is carried out to ultrafiltration obtain filtrate, carry out essence filter by nanofilter, obtain the translucent concentrated liquid of yellowish-brown;
F, employing low-temperature boiling granulation technique, control temperature≤55 DEG C, adds functional raw material taking cornstarch or dextrin as base-material and by 1: 0.1～1: 0.5, and the concentrate of step e gained is carried out to low temperature granulation.
G, after step F makes particle, puddle dolomol remover, and use tablet press machine to carry out moulding compressing tablet;
H, control temperature≤50 DEG C, carry out film coating 3～6 hours, produces out high activity content superoxide dismutase (SOD) Rosa roxburghii composite sheet.
2. the method for claim 1, is characterized in that, the Single Roxburgh Rose Fruit of selecting in steps A is without worm, without moth, without the wild fresh Single Roxburgh Rose Fruit going mouldy.
3. the method for claim 1, is characterized in that, the enzyme adding in step C is cellulase, hemicellulase, pectase.
4. the method for claim 1, is characterized in that, the functional raw material that step F adds is vitamin C or vitamin E or calcium or zinc or iron.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210520478.8A CN103844215A (en) | 2012-11-30 | 2012-11-30 | High-activity and high-content superoxide dismutase (SOD) roxburgh rose composite tablet preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210520478.8A CN103844215A (en) | 2012-11-30 | 2012-11-30 | High-activity and high-content superoxide dismutase (SOD) roxburgh rose composite tablet preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103844215A true CN103844215A (en) | 2014-06-11 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210520478.8A Pending CN103844215A (en) | 2012-11-30 | 2012-11-30 | High-activity and high-content superoxide dismutase (SOD) roxburgh rose composite tablet preparation method |
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| Country | Link |
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| CN (1) | CN103844215A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106072097A (en) * | 2016-06-01 | 2016-11-09 | 贵州天赐贵宝食品有限公司 | A kind of Fructus Rosae Normalis buccal tablet and preparation method thereof |
| CN107212227A (en) * | 2017-06-23 | 2017-09-29 | 安徽省芬格欣生物药业有限公司 | Ribes burejense powder green high-efficient processing method |
| CN107232612A (en) * | 2017-05-26 | 2017-10-10 | 北京和颐林生物科技有限公司 | A kind of B B-complex lozenge rich in high activity SOD and preparation method thereof |
| CN108634314A (en) * | 2018-05-22 | 2018-10-12 | 贵州黔之爱生物科技有限公司 | A kind of production method of dendrobium candidum Rosa roxburghii Tratt lozenge |
| CN111419745A (en) * | 2020-04-01 | 2020-07-17 | 广州今盛美精细化工有限公司 | Roxburgh rose extract and application thereof in preparation of cosmetics |
| CN112168955A (en) * | 2020-08-26 | 2021-01-05 | 上海润日生物科技发展有限公司 | SOD health-care composition with effects of resisting three highs and losing weight and preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002153239A (en) * | 2000-11-22 | 2002-05-28 | Toyo Shinyaku:Kk | Health food |
| CN1587395A (en) * | 2004-08-09 | 2005-03-02 | 陈欣 | Method for producing super oxide mutase complex enzyne at large scale using grain seed |
| CN101073433A (en) * | 2007-06-22 | 2007-11-21 | 上海新康制药厂 | Blackthorn pear fruit-juice solid product and its production |
-
2012
- 2012-11-30 CN CN201210520478.8A patent/CN103844215A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002153239A (en) * | 2000-11-22 | 2002-05-28 | Toyo Shinyaku:Kk | Health food |
| CN1587395A (en) * | 2004-08-09 | 2005-03-02 | 陈欣 | Method for producing super oxide mutase complex enzyne at large scale using grain seed |
| CN101073433A (en) * | 2007-06-22 | 2007-11-21 | 上海新康制药厂 | Blackthorn pear fruit-juice solid product and its production |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106072097A (en) * | 2016-06-01 | 2016-11-09 | 贵州天赐贵宝食品有限公司 | A kind of Fructus Rosae Normalis buccal tablet and preparation method thereof |
| CN107232612A (en) * | 2017-05-26 | 2017-10-10 | 北京和颐林生物科技有限公司 | A kind of B B-complex lozenge rich in high activity SOD and preparation method thereof |
| CN107212227A (en) * | 2017-06-23 | 2017-09-29 | 安徽省芬格欣生物药业有限公司 | Ribes burejense powder green high-efficient processing method |
| CN108634314A (en) * | 2018-05-22 | 2018-10-12 | 贵州黔之爱生物科技有限公司 | A kind of production method of dendrobium candidum Rosa roxburghii Tratt lozenge |
| CN111419745A (en) * | 2020-04-01 | 2020-07-17 | 广州今盛美精细化工有限公司 | Roxburgh rose extract and application thereof in preparation of cosmetics |
| CN112168955A (en) * | 2020-08-26 | 2021-01-05 | 上海润日生物科技发展有限公司 | SOD health-care composition with effects of resisting three highs and losing weight and preparation method and application thereof |
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Application publication date: 20140611 |