CN103830329A - Mint oil soft capsule, and preparation method thereof - Google Patents
Mint oil soft capsule, and preparation method thereof Download PDFInfo
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- CN103830329A CN103830329A CN201210474875.6A CN201210474875A CN103830329A CN 103830329 A CN103830329 A CN 103830329A CN 201210474875 A CN201210474875 A CN 201210474875A CN 103830329 A CN103830329 A CN 103830329A
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- soft capsule
- capsule
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- oleum menthae
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Abstract
The invention provides a mint oil soft capsule, and a preparation method thereof. The mint oil soft capsule is composed of a pharmaceutical liquid oil and a capsule wall material. The mint oil soft capsule is convenient for oral administration; dosage is accurate; patient compliance is high; and the mint oil soft capsule possesses clinical practical value.
Description
Summary
The invention provides a kind of Oleum menthae soft capsule and preparation method thereof, this soft capsule is made up of medicinal liquid oil and capsule material.Soft capsule oral provided by the invention is convenient, and dosage is accurate, and patient compliance is strong, has value for clinical application.
Technical field
The present invention relates to Oleum menthae soft capsule and preparation method thereof.
Background technology
Oleum menthae is colourless or flaxen supernatant liquid.Have special residual refrigerant fragrance, taste is just pungent, rear cool.Deposit with the passing of time, color gradual change is dark, is aromatic drug, remedium corrigens and carminative, can be used for skin or mucosa and produces refrigerant sense and be not suitable for to alleviate, main pain.Because Oleum menthae is hydrophobicity, oiliness medicine, be therefore difficult to make conventional tablet, capsule, the inventor, through a large amount of experimentatioies, has invented this medicinal soft capsule.
Summary of the invention
The invention provides convenient oral, quantitatively accurate, and covered " special fragrance ", eliminated the Oleum menthae soft capsule of " acrid in the mouth and cool ".
The present invention also provides the preparation method of Oleum menthae soft capsule.
Oleum menthae soft capsule provided by the invention is made up of the good liquid soup oil of mobility and capsule material.
Oleum menthae soft capsule liquid soup oil is by Mentholum, Camphora, Oleum Eucalypti, methyl salicylate, eugenol, essence, chlorophyll, liquid Paraffin composition.Preparation method is: get Mentholum 320g, Camphora 30g, adds liquid Paraffin appropriate, then adds Oleum Eucalypti 30g, methyl salicylate 260g, eugenol 30, essence 100g, chlorophyll is appropriate, adds liquid Paraffin to design volume, mix, leave standstill 24hr, get clear liquor, for the preparation of soft capsule.
Capsule material contains sizing material, plasticizer and water, and its weight ratio is 1:0.4-0.6:0.7-1.4, and wherein sizing material can be bright
Glue, arabic gum or its combination, be preferably gelatin, and the gel strength of gelatin generally should be at 150-250 Bo Lumuke, and range of viscosities is 25-45mPaS; Plasticizer can be glycerol, sorbitol or its combination, is preferably the mixture of the two; In capsule material, can also add additives, additives are the compounds that can promote soft capsule disintegrate, are the mixture of sulphuric acid amine and fumaric acid, and wherein sulphuric acid amine accounts for the 0.5-2% of capsule material gross weight, and fumaric acid accounts for the 0.3-1.5% of capsule material gross weight; In capsule material, can also add antiseptic, antiseptic can be methyl parahydroxybenzoate or propyl p-hydroxybenzoate, and it accounts for 0.5-2.0% of gross weight.
Soft capsule provided by the invention can adopt conventional soft capsule preparation technology to make.As manual die pressing, rotating mould platen press or dropping preparation method.Select pressing as rotating mould platen press, use automatic rotation to press capsule machine, temperature is controlled between 40-50 ℃, and every soft capsule Oleum menthae content weight of preparation is between 0.05-0.80g, and preferred weight is 0.2-0.5g, more preferably 0.25g.Dropping preparation method is selected automatic pill dripping machine, and every soft capsule Oleum menthae content weight of preparation is between 0.020-0.200g, and preferred weight is 0.030-0.100g, and more preferably weight is 0.050g.
The specific embodiment
The preparation of embodiment 1. Oleum menthae soft capsules.
A. take respectively Mentholum 3200g, Camphora 300g, adds liquid Paraffin 1000g, heating for dissolving, then add Oleum Eucalypti 300g, methyl salicylate 2600g, eugenol 300, essence 1000g, chlorophyll 100g, add liquid Paraffin to 10000ml, heat, stir, mix, leave standstill 24hr, obtain clarification medicinal liquid.
B. by following prescription proportioning boiling glue: take 33 parts, gelatin, 40 parts, water, 11 parts of sorbitol, 2 parts of glycerol, 1.5 parts, ammonium sulfate, 0.5 part of fumaric acid, 1 part of methyl parahydroxybenzoate.Gelatin is added to the water, allows gelatin water absorption and swelling.Glycerol, sorbitol are added in glue pot and be heated to 60-80 ℃, add swelling gelatin, melting, then add additives, stir.
C. measure medicinal liquid 1000ml, with rotation mold pressing encapsulating machine, adjust every containing content 0.25g, make Oleum menthae soft capsule.
The preparation of embodiment 2. Oleum menthae soft capsules
Measure medicinal liquid 1000ml prepared by embodiment 1, add liquid paraffin 2200mL, with the glue in embodiment 1 b item, with rotation mold pressing encapsulating machine, adjust every containing content 0.80g, make Oleum menthae soft capsule.
The preparation of embodiment 3. Oleum menthae soft capsules
Measure medicinal liquid 1000ml prepared by embodiment 1, with the glue in embodiment 1 b item, with rotation mold pressing encapsulating machine, adjust every containing content 0.05g, make Oleum menthae soft capsule.
The preparation of embodiment 4. Oleum menthae soft capsules
The preparation of glue: take 40 parts, gelatin, 45 parts, water, 20 parts of glycerol, 1 part, ammonium sulfate, 0.3 part of fumaric acid, 0.5 part of methyl parahydroxybenzoate, 0.05 part of propyl p-hydroxybenzoate.Operating process, for gelatin is added to the water, allows gelatin absorb water
Swelling.Glycerol, sorbitol are added in glue pot and be heated to 70-80 ℃, add swelling gelatin, melting, then add additives, and stir, make glue.
Measure medicinal liquid 1000ml prepared by embodiment 1, pack in soft capsule dripping machine, keep fluid temperature at 45-55 ℃, adjusting every loading amount of soft capsule is 0.05g, makes Oleum menthae soft capsule.
The preparation of embodiment 5. Oleum menthae soft capsules
Measure medicinal liquid 1000ml prepared by embodiment 1, pack in soft capsule dripping machine, keep fluid temperature at 45-55 ℃, the glue making with embodiment 4, adjusting every loading amount of soft capsule is 0.020g, makes Oleum menthae soft capsule.
The preparation of embodiment 6. Oleum menthae soft capsules
Measure medicinal liquid 1000ml prepared by embodiment 1, pack in soft capsule dripping machine, keep fluid temperature at 45-55 ℃, the glue making with embodiment 4, adjusting every loading amount of soft capsule is 0.10g, makes Oleum menthae soft capsule.
Test example: volunteer's examination takes Oleum menthae (bottled) and the test of Oleum menthae soft capsule
Call up 60 volunteers, in age 18-40 year, men and women half and half.Be divided at random and take Oleum menthae (bottled) group and Oleum menthae soft capsule group.0.2ml Oleum menthae is added in 100ml water, oral; By 0.2ml Oleum menthae soft capsule with 100ml water delivery service.
Result demonstration, bottled Oleum menthae is refused clothes because its abnormal smells from the patient causes many people, and feeling sick appears in user, and few people are ready again to take; And Oleum menthae soft capsule nobody refuse clothes, also do not occur feel sick.Show that the compliance of Oleum menthae soft capsule is significantly better than Oleum menthae (bottled).
Claims (7)
1. an Oleum menthae soft capsule, is characterized in that being made up of medicinal liquid oil and capsule material.
2. soft capsule according to claim 1, is characterized by capsule material and contains sizing material, plasticizer and water, and its weight ratio is 1:0.4-0.6:0.7-1.4.
3. soft capsule according to claim 2, it is characterized by sizing material is a kind of or its combination in gelatin, arabic gum.
4. soft capsule according to claim 3, it is characterized by sizing material is gelatin.
5. soft capsule according to claim 2, plasticizer is a kind of or its combination in glycerol, sorbitol.
6. soft capsule according to claim 5, the mixture that plasticizer is the two.
7. soft capsule according to claim 1, adds additives in capsule material, and additives are the mixture of sulphuric acid amine and fumaric acid, and wherein sulphuric acid amine accounts for the 0.5-2% of capsule material gross weight, and fumaric acid accounts for the 0.3-1.5% of capsule material gross weight.
8, soft capsule according to claim 2, adds antiseptic in capsule material, and antiseptic is methyl parahydroxybenzoate or propyl p-hydroxybenzoate, and it accounts for 0.5-2.0% of gross weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210474875.6A CN103830329A (en) | 2012-11-21 | 2012-11-21 | Mint oil soft capsule, and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210474875.6A CN103830329A (en) | 2012-11-21 | 2012-11-21 | Mint oil soft capsule, and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103830329A true CN103830329A (en) | 2014-06-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201210474875.6A Pending CN103830329A (en) | 2012-11-21 | 2012-11-21 | Mint oil soft capsule, and preparation method thereof |
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| CN (1) | CN103830329A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016154503A1 (en) * | 2015-03-26 | 2016-09-29 | Banner Life Sciences Llc | Liquisoft capsules |
| CN107740200A (en) * | 2017-09-30 | 2018-02-27 | 金华市伊万卡科技有限公司 | Multi-functional refrigerant sense fiber |
-
2012
- 2012-11-21 CN CN201210474875.6A patent/CN103830329A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016154503A1 (en) * | 2015-03-26 | 2016-09-29 | Banner Life Sciences Llc | Liquisoft capsules |
| US9867779B2 (en) | 2015-03-26 | 2018-01-16 | Patheon Softgels Inc. | Liquisoft capsules |
| US11872307B2 (en) | 2015-03-26 | 2024-01-16 | Patheon Softgels Inc. | Liquisoft capsules |
| CN107740200A (en) * | 2017-09-30 | 2018-02-27 | 金华市伊万卡科技有限公司 | Multi-functional refrigerant sense fiber |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20140604 |